LOCUS       NZ_CP021121            21908 bp    DNA     linear   CON 31-JUL-2024
DEFINITION  Streptomyces marincola strain SCSIO 03032 chromosome, complete
            genome.
ACCESSION   NZ_CP021121
VERSION     NZ_CP021121.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces marincola
  ORGANISM  Streptomyces marincola
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6287975)
  AUTHORS   Ma,L., Zhu,Y., Zhang,W., Zhang,G., Tian,X., Zhang,S. and Zhang,C.
  TITLE     Complete genome sequence of Streptomyces sp. SCSIO 03032 revealed
            the diverse biosynthetic pathways for its bioactive secondary
            metabolites
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6287975)
  AUTHORS   Ma,L., Zhu,Y., Zhang,W., Zhang,G., Tian,X., Zhang,S. and Zhang,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2017) Key Laboratory of Tropical Marine
            Bio-resources and Ecology, South China Sea Institute of Oceanology,
            164 West Xingang Rd., Guangzhou, Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method :: Hierarchical Genome Assembly Process v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 165.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002128305.1-RS_2024_07_31
            Annotation Date                   :: 07/31/2024 06:55:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,513
            CDSs (total)                      :: 5,438
            Genes (coding)                    :: 5,343
            CDSs (with protein)               :: 5,343
            Genes (RNA)                       :: 75
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 95
            CDSs (without protein)            :: 95
            Pseudo Genes (ambiguous residues) :: 0 of 95
            Pseudo Genes (frameshifted)       :: 19 of 95
            Pseudo Genes (incomplete)         :: 88 of 95
            Pseudo Genes (internal stop)      :: 2 of 95
            Pseudo Genes (multiple problems)  :: 13 of 95
            CRISPR Arrays                     :: 12
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:29:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6151706
            Orig. end                         :: 6173614
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP021121.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Key Laboratory of Tropical
            Marine Bio-resources and Ecology.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21908
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="31"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21908
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21908
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11908](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11908
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            421..1488
                     /locus_tag="CAG99_RS26795"
                     /old_locus_tag="CAG99_26870"
     CDS             421..1488
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123: polyprenol-monophosphomannose synthase ppm1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036072.1"
                     /locus_tag="CAG99_RS26795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_26870"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_086161804.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.4e-34,
                     bitscore: 117.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRPLVSVVIPNYNYRNSIGLCIDAALQQTYAPLEVIVVDDHSTD
                     DSLEIARRRDVTVLRTPRNSGVAVARNTGAAAARGEILFFVDSDVALRPDAVEKAVEEL
                     LAHPEYGAVCGIYEDQPLIRDSVVEECRVLQAYCWRMDSLGTVSFLFSSLTAIPRRVFQ
                     EIGPFNPRLRQTEEVDYGERMSEHYRIRVTPHVLGRHDDDEKLLPLLRKLFRRARLRVP
                     LFARRRRFAKGFETAPRSMAAVAALGTVLTLPLVLLGPVWLAVPLALAGVTIAGDFSMY
                     RYVLKRRGAGFLVVFTAVAFATNVAISAGIAVGVLHWLASGRFRRLYDSHLSPDGEHAP
                     RPLGTRPEQRPGMTA"
     gene            1485..2636
                     /locus_tag="CAG99_RS26800"
                     /old_locus_tag="CAG99_26875"
     CDS             1485..2636
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015338.4"
                     /locus_tag="CAG99_RS26800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_26875"
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_086161805.1"
                     /transl_table=11
                     /translation="MSTRLARAQESAAAREGPPPAAPPPPRGRAARLLAAAIVVWTLFV
                     AVFMVLTGEHWWWRPAELMPPLTFVVVPLLLVLLAPLARPARLRLGAAALCGVLLGLPL
                     AGLNVHALPGVSGGSPAPPDAVRVFAWNTEYWADGDDPDAFYAYLRAQRADVYLLQEHV
                     SWDSGAHRPVPADHVAALSEHFPGFHVVALGELLTLSRYPIEDWRGLDNWPHLSDPAIG
                     MPPAGGYPDYYRYKTLRTDLRIDGRLTTFYNVHVPVQLDVSMDPFSSRFVSFMRAQEVR
                     RQATYRALEEDLDGNELPAVVAGDMNATSAMGELGRLGDRLRDALHASDQLHPVSWPAG
                     GPAMWRLDWAFTSDAVTVHDYRMVDSEGLSDHRAQALTVTPGG"
     gene            2848..3801
                     /locus_tag="CAG99_RS26805"
                     /old_locus_tag="CAG99_26880"
     CDS             2848..3801
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014181333.1"
                     /locus_tag="CAG99_RS26805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_26880"
                     /product="aldo/keto reductase"
                     /protein_id="WP_086161806.1"
                     /transl_table=11
                     /translation="MQQRTLDEATGTRVSALCLGAMPFGTTVDEETSFAILDRFVEAGG
                     TTIDTANCYSFWVPGGQGGESENVLGRWLKDRGGRDRLTIASKVGSGLAADGGAEGLAP
                     EVIRTELEGTLRRLGTDHLDLYYAHREDRSTPDEETIAAFHQAVTEGRTRTLGASNHAA
                     WRLAETRSLAQRRGWTPYTAVQQRWSYLRPRPGTTLPEGGHVHATDDLLDYVHSHRLTF
                     FAYTTLLWGAYSRPGQPLPEHYDHPGTERRLRALAKVSAELGASPVQVVLSWLIGGEPA
                     VVPIIGVSSVAQLDECLAAADLELPGELRQVLDEAV"
     gene            3906..4967
                     /locus_tag="CAG99_RS26810"
                     /old_locus_tag="CAG99_26885"
     CDS             3906..4967
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123: polyprenol-monophosphomannose synthase ppm1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF025025.4"
                     /locus_tag="CAG99_RS26810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_26885"
                     /product="glycosyltransferase"
                     /protein_id="WP_086161807.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.4e-32,
                     bitscore: 111.2, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTASSVPAAGNSRSQDRVSVVIPNYNYARTLQLCLASLAAQTLPP
                     HEVIVSDDASTDNSVEVALRAGCRVLRADRNEGVSAARNRGAAAASGDIIFFLDSDQAL
                     SPDSLENAVALLSEDPGLGCVHGIIAAEPLVDDGPVEWYRTLHAHYWRLKGVGPTPTAY
                     FAAAALPRRVFEEVGPFDRALRDSEDVEYSERLSARYGIRLTDRIVAAHDEEHRLGRML
                     REQFRRAQYLLPFAAAHRRRPGALRANSELGVAAALFTAATVPLAAFHPALLLLPLVGT
                     AAFAAADPGLLRFVRRKRGARFLPLFVGLHLLVNVQIALGAATGWARARLDRDFGRGAH
                     GRRPRAEGMGSGV"
     gene            4960..5673
                     /locus_tag="CAG99_RS26815"
                     /old_locus_tag="CAG99_26890"
     CDS             4960..5673
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013672.4"
                     /locus_tag="CAG99_RS26815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_26890"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_107485931.1"
                     /transl_table=11
                     /translation="MSDAVRAHIGQAAWSLVRRAESWRAGGGRTPARPLLAPGPLFRVP
                     AGAGGGNVPCRVVLTVDDGPDPRWTPRLLDVLDAHDVRATFFVVGERAARHPELLRRIV
                     GAGHTLGNHSYSHPQPFAARTAEEIHEEIRRTQHVVAQETGRTPVHFRAPAGGWSRAVL
                     DAARDQGLTPVDWSVDPKDWRSPPVPRIVRTVSKARHGDIVLCHDGGGERSRTVAALDV
                     ALGLLRRRGVAVTPL"
     gene            complement(5810..6730)
                     /locus_tag="CAG99_RS26820"
                     /old_locus_tag="CAG99_26895"
     CDS             complement(5810..6730)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677019.1"
                     /locus_tag="CAG99_RS26820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_26895"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_159029964.1"
                     /transl_table=11
                     /translation="MSTKDEVREFLISRRANVSPEQAGLTGVGGERRVPGLRREEVAMI
                     AGVSPDYYTRLERGNIRGASESVLNAIARALQLNDVEREYLFDLARTAPAPARSRGERP
                     ALRSVRASVQRVLDNLTLPALVHNANQDLIAANLMGRALYAPHYDTPHQPNIARFVFLD
                     PRAPDYYVDWPLARRTTAAVMRLEAGRDPLNGELTALIGELSTRSPLFRTDWADHDVHA
                     HRTGVKSFRHPEVGPLDVSFDVFEMPGEAGLQIVTYSPAPGTRSADAFALLASWAATQE
                     PDGGRPDDAPEGREASPDEAPRPPR"
     misc_feature    complement(6740..6753)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.61"
                     /tool="antismash"
     gene            complement(6808..7857)
                     /locus_tag="CAG99_RS26825"
                     /old_locus_tag="CAG99_26900"
     CDS             complement(6808..7857)
                     /EC_number="1.1.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (21-297). E-value: 6.7e-15.
                     Score: 46.9. Matches aSDomain:
                     nrpspksdomains_CAG99_RS26825_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444294.1"
                     /locus_tag="CAG99_RS26825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_26900"
                     /product="NAD(P)-dependent alcohol dehydrogenase"
                     /protein_id="WP_086161808.1"
                     /sec_met_domain="ADH_N (E-value: 5.7e-31, bitscore: 105.0,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.8e-20, bitscore:
                     71.0, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSVRAYTATSAAGPLAPGVIERRDVGPKDVRIDIHWAGICHSDI
                     HTVRGDWGPVPYPLTVGHEIAGVVAEVGPEVTRYRVGDRVGVGCMVDSCRECDNCRAGR
                     EQYCLAGFTDTYNGTDRDGGVTQGGYATGIVVDEHFVLRVPEAIPFEKAAPLLCAGITT
                     YSPLRRWNAGPGKKVAVVGMGGLGHMAVKIAHAMRAEVTVLSQTLGKREDGLRFGADHY
                     YATSDPTTFKRLANTFDLIINTVSAPLDLDAYLALLSFGGTIVSVGAPPEAVPVTLFTL
                     FENQRSFAGSKIGGIAETQEMLDFCAEHGIAPEVEIIPAERINEAWERVLSSDVRYRFV
                     IDTATLDAA"
     aSDomain        complement(6967..7794)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CAG99_RS26825_PKS_ER.1"
                     /evalue="6.70E-15"
                     /label="CAG99_RS26825_PKS_ER.1"
                     /locus_tag="CAG99_RS26825"
                     /protein_end="297"
                     /protein_start="21"
                     /score="46.9"
                     /tool="antismash"
                     /translation="ERRDVGPKDVRIDIHWAGICHSDIHTVRGDWGPVPYPLTVGHEIA
                     GVVAEVGPEVTRYRVGDRVGVGCMVDSCRECDNCRAGREQYCLAGFTDTYNGTDRDGGV
                     TQGGYATGIVVDEHFVLRVPEAIPFEKAAPLLCAGITTYSPLRRWNAGPGKKVAVVGMG
                     GLGHMAVKIAHAMRAEVTVLSQTLGKREDGLRFGADHYYATSDPTTFKRLANTFDLIIN
                     TVSAPLDLDAYLALLSFGGTIVSVGAPPEAVPVTLFTLFENQRSFAGSKIGGIA"
     misc_feature    7860..7880
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.34"
                     /tool="antismash"
     gene            complement(8243..9157)
                     /locus_tag="CAG99_RS26830"
                     /old_locus_tag="CAG99_26905"
     CDS             complement(8243..9157)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013226.4"
                     /locus_tag="CAG99_RS26830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_26905"
                     /product="prenyltransferase"
                     /protein_id="WP_159029965.1"
                     /transl_table=11
                     /translation="MDADVPPKTPAARESARTWVQAAGPPLVLVLVLQGAFAVTAVRHQ
                     GAVEGWRVALTVLLFVCDGIGRRLVNDFEDHRRGVDRPDRVRPDSSMALGLDMNRVRWA
                     GMGGFAAAWVCLLVLALTSEPLLLLVIPPMYAAYFAYAGGRRPLGHRGFGELLDFVVTG
                     TAVTLVIGRLNGDAFDAALWCAALACGFLFMTLMLHNNARDLAKDREAGKVTLPHLIPS
                     AAVKALYVTGLAGCYGFLALTALSLGAWGPLLPLVTLPWAALLAVRVCRGPLGTRMIDW
                     SGLYLLMLAVFATFTAGGWLPAW"
     misc_feature    complement(9175..9189)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.12"
                     /tool="antismash"
     gene            9385..9924
                     /locus_tag="CAG99_RS26835"
                     /old_locus_tag="CAG99_26910"
     CDS             9385..9924
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /GO_process="GO:0008150 - biological_process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03666.1"
                     /locus_tag="CAG99_RS26835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_26910"
                     /product="PPOX class F420-dependent oxidoreductase"
                     /protein_id="WP_086161810.1"
                     /transl_table=11
                     /translation="MSQERVRPLARPVAGRSLPGGRVADRLSLPPARILELLDAAYPAG
                     RAESARRVRETLARGKHALLITFRAGGGRVATPVWAAVEAERVYVRTQRASGKVARVGR
                     RPQVLLGVCSTRGRPLTGVVPATARVLPAGEERHAERLLHHRYGAVRAFCATAQDLMRV
                     DMCYLEITVGDDNPAG"
     gene            10001..11908
                     /locus_tag="CAG99_RS26840"
                     /old_locus_tag="CAG99_26915"
     CDS             10001..11908
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF024640.4"
                     /locus_tag="CAG99_RS26840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_26915"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_159029966.1"
                     /sec_met_domain="T2TS (E-value: 1.2e-82, bitscore: 276.4,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDQSHKPNDAQVGAAVSAAVSAAFAAQAQDGAWPGEILTGGTSY
                     EAADIVMRTLLGATTPRHVEELAAWMLADQNEDGGWSLFRGGPSDLSSSAFTHIALQLA
                     GFPLDHEALRRAAAFVRSAGGLEAIDMVPVKFWLAFTGMVSWDEIPRVPPELVLLPSWV
                     PGALGDYEPMAREVVVAVGILTTIRPVRRLDVDVTELRSGVPHPPSRAESVLTGTLRAV
                     HAATPRTLRAKALRAGEDWLMARQESDGSWGGSWTETMVCVLALWSRGYGIGHPVQRRA
                     LAACDELNVRVDGTRRVQTFRTVVMDSALMMSALDATGRTDVREPLRRAGRWLIDHRAD
                     TSVNTKGVRPLRAWDFEGIPTINADPDDTAMAITALRSAGASDGGADDEAVAATSEAAR
                     WLIACQSPSGGWAGFGVDRWSRLGEKALTGIGFVEGATACVTAHAVEALHAEGLGWHPG
                     CRRAVRWLLDAQDADGSWPSRWGVRLYGTSHVVSALRTAGAPAGHPSIVAARRWLLAHQ
                     NPDGGWGENIALSLSDRRRATGESSAIHTAWCLRGLLRAGEVDEDAVAAAAGYLISHQN
                     EAGTWTDPTEWMIVIPDSVYISTPRMTHAFALWALADYQRHLSAVASGAAHPDQGKAAE
                     "
     gene            11905..12627
                     /locus_tag="CAG99_RS26845"
                     /old_locus_tag="CAG99_26920"
     CDS             11905..12627
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471571.1"
                     /locus_tag="CAG99_RS26845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_26920"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_086161812.1"
                     /transl_table=11
                     /translation="MTTPLRDTTEYDDWSEQWWDPRGPFSTLSWIARQRASLIPQAPAG
                     TGGTPLLVDVCCGGGLLHPHIADKGYRHVGVDASALSAEVARSRGVDEVIHADVHRVPL
                     PDGCADVVVAGQCLEHVDRPWEVIAECCRLLKPGGLVIADTIADTLLARLAIITLAENV
                     PLSWMAPKGCHDHRMFVNPRRLAFEFARNGVPVQTYGLFPDKRDLLAWVLNRTDRVRLR
                     RIASTDVIYQAIGRKPAA"
     gene            complement(12673..13755)
                     /locus_tag="CAG99_RS26850"
                     /old_locus_tag="CAG99_26925"
     CDS             complement(12673..13755)
                     /NRPS_PKS="Domain: PKS_ER (107-357). E-value: 1.7e-23.
                     Score: 75.2. Matches aSDomain:
                     nrpspksdomains_CAG99_RS26850_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024989.4"
                     /locus_tag="CAG99_RS26850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_26925"
                     /product="alcohol dehydrogenase catalytic domain-containing
                     protein"
                     /protein_id="WP_255308493.1"
                     /sec_met_domain="ADH_N (E-value: 2e-20, bitscore: 71.0,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.4e-17, bitscore:
                     61.5, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISTAVRVPAVTRSMVLRRFGDPETALELTERHPVPAPGRGEVLI
                     AVRAVSVGRTLDLATRAGLPPFAPQVRLPHVLGADHVGEVVAHGDGVGGPALGTRVAVF
                     PVVCCGRCDACAAGRTELCGGMELIGVHRPGAYAGYCRVPAANVRPVPEDMSDGAACAL
                     ALNGPVAHRQLEVAGVEQGDWVLVNGAAGGLGTALCAVALHRGLRVLACARQPWQREAL
                     RTLGVQAALDPGADDFAAAVGSLTDGRGVAAVVDNLATQELAAALPAVLAPGGALVCSG
                     ALGAGTARLDLRALYLRSQRVLGVRTARLTDVDATWAAAAGGLRPVVDERRAFGVEDAA
                     EAHRYLDEGRNFGRVVLAWS"
     aSDomain        complement(12685..13434)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CAG99_RS26850_PKS_ER.1"
                     /evalue="1.70E-23"
                     /label="CAG99_RS26850_PKS_ER.1"
                     /locus_tag="CAG99_RS26850"
                     /protein_end="357"
                     /protein_start="107"
                     /score="75.2"
                     /tool="antismash"
                     /translation="CCGRCDACAAGRTELCGGMELIGVHRPGAYAGYCRVPAANVRPVP
                     EDMSDGAACALALNGPVAHRQLEVAGVEQGDWVLVNGAAGGLGTALCAVALHRGLRVLA
                     CARQPWQREALRTLGVQAALDPGADDFAAAVGSLTDGRGVAAVVDNLATQELAAALPAV
                     LAPGGALVCSGALGAGTARLDLRALYLRSQRVLGVRTARLTDVDATWAAAAGGLRPVVD
                     ERRAFGVEDAAEAHRYLDEGRNFGRVVL"
     CDS_motif       complement(12994..13026)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CAG99_RS26850_0002"
                     /evalue="1.70E+01"
                     /label="PKSI-ER_m5"
                     /locus_tag="CAG99_RS26850"
                     /protein_end="254"
                     /protein_start="243"
                     /score="-1.3"
                     /tool="antismash"
                     /translation="SLTDGRGVAAV"
     CDS_motif       complement(13156..13212)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CAG99_RS26850_0001"
                     /evalue="1.10E-03"
                     /label="PKSI-ER_m5"
                     /locus_tag="CAG99_RS26850"
                     /protein_end="200"
                     /protein_start="181"
                     /score="11.7"
                     /tool="antismash"
                     /translation="GDWVLVNGAAGGLGTALCA"
     gene            14129..15004
                     /locus_tag="CAG99_RS26855"
                     /old_locus_tag="CAG99_26930"
     CDS             14129..15004
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031410.1"
                     /locus_tag="CAG99_RS26855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_26930"
                     /product="hypothetical protein"
                     /protein_id="WP_086161814.1"
                     /transl_table=11
                     /translation="MPLRTRRRRHAAMTGLLALATAAALAIAPPAAAADTWTEVGSDRA
                     RPLTESQGLTSVEVPADSPNRYTGIGTIPPDVALRGWNHVGDPDASYDGHYIEPYQRDS
                     GSAKMFRVQAPDGSWAEYVHALGPGEALNNSWVAVSPDGQWMLAGEYGTMSRLLVFPTP
                     GVNPATSPSADLPHVATVHLDRPVRDVQGCDFSGPTTLLCSSDDPAGTLFGMTKPLLQV
                     DLSGAPSGTADVSGRVTALRQLPLRSGCSGAFEAQGVDYDRRTGTLRVIVMSPGFCVLT
                     DSMTYRFTRG"
     gene            complement(15081..15908)
                     /locus_tag="CAG99_RS26860"
                     /old_locus_tag="CAG99_26935"
     CDS             complement(15081..15908)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012669.4"
                     /locus_tag="CAG99_RS26860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_26935"
                     /product="DeoR/GlpR family DNA-binding transcription
                     regulator"
                     /protein_id="WP_086161815.1"
                     /transl_table=11
                     /translation="MPQDPLKYRAAPARRDEILDALRETGFLSIAEVAARLGVSEMTAR
                     RDIRRLAADAEVLAVRGGVVLPTGPRDRSAPAYSSRSAADVEEKRTVGRVAATCVRDDD
                     VIAVDAGTTAYQLAAALPDSFHGTVVTHSVPVIDLLMDRPSARGIALGGDLFAPSRALV
                     GSLTVDTAKRLKVRTFYLGAAGVDERGIYAAADVERQVKETLMDIAERVVLLIGRRKFT
                     TTAPVLLCGWDRLDAVVTDVEPPPPVHRTLESNGVRLVLPTTEPATLRPPPAR"
     misc_feature    complement(15965..15982)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.6"
                     /tool="antismash"
     misc_feature    15966..15979
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 21.07"
                     /tool="antismash"
     misc_feature    16053..16067
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.38"
                     /tool="antismash"
     gene            16136..17080
                     /locus_tag="CAG99_RS26865"
                     /old_locus_tag="CAG99_26940"
     CDS             16136..17080
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_function="GO:0016773 - phosphotransferase activity,
                     alcohol group as acceptor [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276: PfkB domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012515.4"
                     /locus_tag="CAG99_RS26865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_26940"
                     /product="carbohydrate kinase family protein"
                     /protein_id="WP_086161816.1"
                     /transl_table=11
                     /translation="MSGTEAAVVCVGVVTLDALALVDRHPDADERVLAERVAISGGGPA
                     ATAAVVMARQGVRVSFVGRVGTDPEGEQAVELLAREGVDVSRVLRDPATATQSSVVLAA
                     SGTGTRCIATRAVPPLPALDGPAADLVADADWVHTDHLGFAPVADLLERSARPGARRPA
                     LAVDAGNDVPGLDGRLGLVDLYVPTAASLTARYGATRTTPDALADCAARALAEGAGAVV
                     ATSGGEGSAAWWPGGGHAAAPAARGVEIVSTLGAGDVFHGALLAAVCHGLDWPDALRHA
                     NAAAALSCRALDGRGAVPDLAELTAFLAAAPAA"
     gene            17108..17995
                     /locus_tag="CAG99_RS26870"
                     /old_locus_tag="CAG99_26945"
     CDS             17108..17995
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013916.4"
                     /locus_tag="CAG99_RS26870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_26945"
                     /product="aldolase"
                     /protein_id="WP_086161817.1"
                     /transl_table=11
                     /translation="MTATTDRAAVLADIARPSGGFAMLAVDQREAMRLMFAAAGTAPVP
                     DQVLTDFKVKATEVLSPHASGVLVDRQFAYDAVLDAKAVHPDCGLIVAADAFLPGNGVP
                     VDAVAIDEDVDPAAVRARGGAALKLLVLWRQDEDPEERRAMVADFTARCRAAGLVSIIE
                     PVVRPPRRGWEFDREAAIVAAARELGDSGADLYKGEMPHGGDADDATLLSACRAIDDAV
                     AMPWVILSSGVEADLFGNAVRIACRAGASGFLAGRAVWKSVIGARNTEAVLRDVSVPRL
                     RRLADIVDEAVAAR"
     gene            18085..19095
                     /locus_tag="CAG99_RS26875"
                     /old_locus_tag="CAG99_26950"
     CDS             18085..19095
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012335.4"
                     /locus_tag="CAG99_RS26875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_26950"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_086161818.1"
                     /sec_met_domain="ADH_N (E-value: 4.6e-28, bitscore: 95.6,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 8.6e-16, bitscore:
                     56.4, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTVSRILFTAPGEVATEATEEPDAPLPTGHVRIAPQYLGICGSD
                     LHVLHGGHPFAKPPLVPGHELSAVVVETAPDVTGVAVGDRAVIDPIMACGACRACRAGR
                     PNLCEPPRVAGFRAPGFGRTSHVVPAANAHVAPASLPLDRLAFAEPVACAVHCLSRVPN
                     PADREDLLVIGAGTIGLTIVQALRVSGAGRLTVQEPDPAKRDLARRFGADVAVAPGDLP
                     EDAAYTAVIDVVAAQATLDEATTRVLPGGPVVVMGVPSGPREVPLPSMQRFERDLLGSG
                     MYVPGDFDTAIAWLADGRFRTDGLITDTFSLREAAAAYRRAAAPDSIKVLVRLAE"
     gene            19129..20562
                     /locus_tag="CAG99_RS26880"
                     /old_locus_tag="CAG99_26955"
     CDS             19129..20562
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1169: sugar
                     transport protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012312.4"
                     /locus_tag="CAG99_RS26880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_26955"
                     /product="MFS transporter"
                     /protein_id="WP_086161819.1"
                     /transl_table=11
                     /translation="MSTSQPAVIRRPQDVVDLVNSHPAKRGGTGVALIALGGVLIDAYQ
                     AAMVGFGNSYIADEYDISTGAAAAVNATVLVAALVGGLMARPLIERLGQRRAFLLGMGL
                     CTVAAAAVAFAPSIWFVLLCRVVMGIGLGIDFPLATSAVVELSGSKSSKSGRSVNLWQM
                     GWYISTTVVYLVLLPLHQATSVESDLWRYGIFVGAAFAALVMVLRYVFIGESALWAARR
                     QRYDEAVRILRERYGVHAVVAHDAVGAAPGSERPRVRGAYRVMFNRTYRRRTVLGCVVA
                     TMQAWQYNAVGIYLPVTLGGVLSGGLAGSLGGSALVNAAFGITGGLLGSLWVQRHGARK
                     LSMAGFAVVAASLLVLGALGSGAPWVALFLLGLIIFGHAAGPGGLGMTIATLSYPPSIR
                     PAGVGFARAIMRTGAIAGLVLWPMLWDALGTDAFFWLALVPATGLITCLIIRWEPIGQP
                     VDDEDADVLRQITVTERAT"
     gene            20627..21532
                     /locus_tag="CAG99_RS26885"
                     /old_locus_tag="CAG99_26960"
     CDS             20627..21532
                     /EC_number="1.1.-.-"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1100: 3-hydroxyisobutyrate dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015411.4"
                     /locus_tag="CAG99_RS26885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_26960"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_086161820.1"
                     /transl_table=11
                     /translation="MSNTTRNGPVIGFVGAGAMGGAVCSRLASGGHRVRVFDLSHAAVT
                     ACVAAGAEPAADAADAVRGADVVFTSLPTPELVAGFWGDNLPHLAAGAVAVDLSTVDPA
                     TSRRVADRVTAHGASFVACTLGRTPQHAENGDIPAFVGGESEAVERVRPLLDRLASSVH
                     PLGDVEAATAFKLISNLIGMTNLAVLAEGYVLARRAGIAPEAFAAALEETGADSFQSRV
                     RLPWIMADDLAARFSVDLAAKDVRLAVEAAARWSVPTPVAAAGLSALVAAGAAGHGRSD
                     AAAVVETYDPRRTARGPVTD"
ORIGIN
        1 ggctgctggt ctcggtgttc tcgctctgcc tcatcttcgt cctgggcaag cgccggcacg
       61 agatgcaggc cggcggcgtc tcccaccgcc ccgcgctgcg cggctactcc gtgccgtacc
      121 tcgaccacct gatcgtgctg tgcgccggag tgaccgtgac cgccttcctc atccatctcc
      181 agcaggcggc cgacccccgc gccgccgacc tcgcggtgta cggctccgcg ccgctcgcgc
      241 tgttcgccat ggccaggtac ctgcaactgc tccaggtcca cggcgaccgc ggcggcgaac
      301 ccacccgcat cctgctgcgc gatcgcgcca tgctcgtcaa ctccctgctc tgggcactcc
      361 tgctcggcgg gacactcatc gtcaaccacg gctagtacgg cccccgttgg aggaactccc
      421 ttgtcccggc ccctcgtctc ggtcgtcatc cccaactaca actaccgcaa ctcgatcggg
      481 ctgtgcatcg acgcggccct gcaacagacc tacgccccgc tcgaagtgat cgtggtcgac
      541 gaccacagca ccgacgactc cctggagatc gcgcgccgcc gcgacgtcac cgtgctccgg
      601 accccgcgca acagcggtgt cgccgtggcc cgcaacaccg gcgccgcggc ggcgcgcggc
      661 gagatcctgt tcttcgtcga ctcggacgtg gccctgcgcc ccgacgccgt ggagaaggcc
      721 gtcgaggaac tgctcgccca ccccgagtac ggtgcggtgt gcggcatcta cgaggaccag
      781 ccgctgatcc gggacagcgt ggtcgaggaa tgccgcgtgc tccaggccta ctgctggcgg
      841 atggactcgc tcggcacggt cagcttcctg ttctcctcgc tcaccgcgat cccgcgccgg
      901 gtgttccagg agatcggacc gttcaacccc cggctgcggc agaccgagga agtcgactac
      961 ggcgagcgga tgtcggagca ctaccggatc agggtcaccc cgcacgtgct cgggcggcac
     1021 gacgacgacg agaagctgct gcccctgctg cgcaagctgt tccgccgcgc ccggctgcgg
     1081 gtgccgctgt tcgcccgccg caggcgcttc gccaagggct tcgagaccgc gccccggtcc
     1141 atggccgccg tcgcggccct cggcacggtg ctcacgctgc cgctcgtcct gctcggcccc
     1201 gtgtggctgg ccgtgccgct ggccctggcc ggggtcacga tcgccggcga cttctccatg
     1261 taccgctacg tgctcaagcg gcgcggggcg ggcttcctcg tcgtcttcac cgcggtggcc
     1321 ttcgccacga acgtcgccat ttcggcgggc atcgcggtgg gcgtcctgca ctggctggcc
     1381 tcgggccgct tccgccgcct gtacgactcc cacctgtcgc ccgacggcga gcacgcgccg
     1441 cggcccctgg ggacgcgccc ggagcagcgg cccgggatga cggcatgagc acgcgcctcg
     1501 cgcgggccca ggagagcgcc gcggcccgcg agggcccgcc gccggccgcg cccccgccac
     1561 cgcgcgggcg ggcggcgcgg ctgctggccg cggcgatcgt ggtgtggacg ctgttcgtcg
     1621 cggtcttcat ggtcctcacc ggcgagcact ggtggtggag accggcggag ctgatgcccc
     1681 cgctgacgtt cgtggtggtg ccgctgctcc tggtgctcct cgcgccgctg gcgcgcccgg
     1741 cccggctgcg cctgggggcc gcggcgctgt gcggcgtgct gctcggactg cccctggcgg
     1801 gactgaacgt ccacgcgctg cccggagtgt ccggcgggtc gcccgcgccg ccggacgcgg
     1861 tccgggtgtt cgcctggaac accgagtact gggccgacgg cgacgacccg gacgcgttct
     1921 acgcctacct gcgcgcccag cgggccgacg tctacctgct ccaggagcac gtctcctggg
     1981 attcgggcgc acaccgcccc gtccccgccg accacgtggc cgcgctgagc gagcacttcc
     2041 ccgggttcca cgtggtcgcc ctcggcgagc tgctgaccct ctcccggtac ccgatcgagg
     2101 actggcgggg gctggacaac tggccgcacc tctccgatcc cgccatcggc atgccgccgg
     2161 cggggggata ccccgactac taccggtaca agacactgcg caccgatctg cggatcgacg
     2221 ggcggctgac caccttctac aacgtgcacg tcccggtgca gctcgatgtg tcgatggacc
     2281 ctttctcgtc gcggttcgtc tccttcatgc gggcccagga ggtccggcgg caggcgacct
     2341 accgggcact tgaggaggac ctggacggca acgagctgcc cgcggtcgtg gcgggagaca
     2401 tgaacgccac ctcggccatg ggcgaactgg gccgcctcgg cgaccggttg cgggacgcgc
     2461 tgcacgcgag cgaccaactg caccccgtct cctggcccgc gggcggcccg gccatgtggc
     2521 gcctcgactg ggccttcacc agcgacgcgg tgaccgttca cgactaccgc atggtggaca
     2581 gcgagggcct gtccgaccac cgggcgcagg cgctcaccgt gacgcccggc ggatgagcct
     2641 cgcgcgcccc gccggtggca ggtcgtacgc cggcggccgg acccgtacga cgaaggtcgt
     2701 agcgcaggcg ctccgaaacg cccggatcac acctgaggcg tccctgagca cccgcggatt
     2761 cttctacggt gtcctcacca tcagtcaacg gccgtacggg cgggccgaaa agcggcgccc
     2821 aggaccgtga ccattctcgg aggaacgatg cagcagcgaa ccctggacga ggccaccggc
     2881 acccgggtca gcgcactgtg cctgggcgcc atgcccttcg gcacgaccgt ggacgaggag
     2941 acgtccttcg ccatcctgga ccgcttcgtc gaggcgggcg ggaccaccat cgacaccgcg
     3001 aactgctact cgttctgggt gccgggcggc cagggaggcg agagcgagaa cgtgctgggc
     3061 cgctggctga aggaccgcgg cggccgggac cggctgacca tcgcatccaa ggtcggttcc
     3121 ggactcgcgg ccgacggcgg ggcggaaggg ctcgcgcccg aggtgatcag gaccgaactc
     3181 gaagggaccc tgcgcaggct gggcaccgac cacctcgacc tctactacgc gcaccgcgag
     3241 gaccggtcga ccccggacga ggagaccatc gccgcgttcc accaggcggt gacggagggc
     3301 aggacccgca cgctgggcgc gagcaaccac gccgcctggc ggctcgcgga gacccggtcg
     3361 ctggcacagc ggcgggggtg gaccccgtac accgcggtgc agcagcgctg gtcctacctg
     3421 cggccccggc ccggcaccac gctgcccgag ggcgggcacg tgcacgccac ggacgacctg
     3481 ctcgactacg tgcacagcca ccggctcacc ttcttcgcct acaccacgct gctctggggc
     3541 gcctacagcc gcccgggcca gccgctgccc gagcactacg accacccggg gaccgaacgc
     3601 cgcctgcgcg cgctcgccaa ggtgtccgcc gagctggggg cgtcgccggt ccaggtggtc
     3661 ctgtcctggc tgataggcgg cgagcccgcc gtcgtcccga tcatcggggt cagctcggtc
     3721 gcccagctcg acgaatgcct cgccgccgcc gacctggaac tgcccgggga gctgcgtcag
     3781 gtgctcgacg aggccgtctg acccgaaccc atccaaccgc cggccgcgcc ggtgagcggc
     3841 gcccggccgg cggtaccccg ccggccggcg ccggaccggc cgcgccacgc ccggaggtgt
     3901 cacccatgac cgcgtcctcc gttcccgcgg cggggaactc ccgttcccag gaccgggtat
     3961 ccgtcgtcat ccccaactac aactacgcca ggacgctcca gctgtgcctg gcctcgctcg
     4021 ccgcccagac cctcccaccg cacgaggtga tcgtctcgga cgacgcgagc accgacaact
     4081 ccgtggaggt ggccctgcgc gccggctgcc gcgtcctgcg ggccgaccgc aacgaaggcg
     4141 tctccgccgc gcgcaacagg ggggccgccg ccgcgagcgg cgacatcatc ttcttcctcg
     4201 actccgacca ggcgctgtcc cccgactccc tggagaacgc cgtcgcgctg ctctccgaag
     4261 accccgggct cggctgcgtg cacggcatca tcgccgccga acccctggtg gacgacggcc
     4321 cggtggagtg gtaccgcacc ctgcacgcgc actactggcg gctcaagggc gtcggcccga
     4381 cgcccacggc gtacttcgcc gccgcggcac tgccgcgccg cgtgttcgag gaagtcgggc
     4441 cgttcgaccg ggcgttgcgc gacagcgagg acgtggagta cagcgaacgg ctgtccgcca
     4501 ggtacggcat ccggctcacc gaccggatcg tggcggcaca tgacgaggag caccggctcg
     4561 gccggatgct ccgcgagcag ttccgccgcg cccagtacct gctgcccttc gccgccgcgc
     4621 accgccggcg ccccggcgcg ctgcgcgcca acagcgaact cggcgtggcg gcggccctct
     4681 tcaccgcggc caccgtgccc ctggccgcct tccaccccgc gctgctgctg cttcccctgg
     4741 tcggcaccgc cgcgttcgcc gccgccgacc ccgggctgct ccgcttcgtg cgccgcaagc
     4801 ggggggcccg gttcctgccc ctgttcgtcg gtctgcacct gctggtcaac gtccagatag
     4861 ccctgggcgc cgcgaccggg tgggcgcgcg cccggctcga ccgcgacttc ggacgcgggg
     4921 cgcacggccg gcggccccgg gccgagggga tgggcagcgg tgtctgacgc cgtacgcgcc
     4981 cacatcggcc aggcggcctg gagcctggtg cgccgcgcgg agtcctggcg ggccggcggg
     5041 ggccggacgc ccgcgcgccc cctgctggcg ccggggccgc tgttccgcgt cccggccggg
     5101 gcgggcggtg ggaacgtgcc gtgccgggtg gtgctgaccg tggacgacgg ccccgacccc
     5161 cggtggacac cgcggctgct ggacgtgctc gacgcccacg acgtgcgggc gaccttcttc
     5221 gtggtgggcg aacgagcggc ccggcaccct gagttgctgc ggcggatcgt gggggcgggg
     5281 cacacgctcg gcaaccacag ctacagccat ccgcaaccct tcgccgcccg caccgccgag
     5341 gagatccacg aggagatccg gcgtacccag cacgtcgtcg ctcaggagac cgggcgcacg
     5401 cccgtgcatt tccgcgcccc cgccgggggc tggtcgcggg ccgtgctcga cgccgcgcgg
     5461 gaccaggggc tcacccccgt cgactggagc gtggacccga aggactggcg ttcgccaccg
     5521 gtgccgcgca tcgtgcgcac cgtttcgaag gcgcggcacg gcgacatcgt gctgtgccac
     5581 gacggcggcg gggaacgttc gcggaccgtc gccgcgctcg acgtggcgct ggggctgctg
     5641 cgccggcgcg gtgtggccgt caccccgctg tgaccggcgg gaccgcgagc acgacgccgg
     5701 ccgttcgcgc gcccgtcacc gctgatcgtg gcgcgcggcg cacgcgccgg agggtgagga
     5761 acgggagggc gggcgcggtg cccgccctcc cggcgccggg caccgcgcgt caccgcggcg
     5821 gacggggcgc ctcgtccggg ctggcctccc ggccctcggg ggcgtcgtcc ggccgcccgc
     5881 cgtccggctc ctgggtcgcg gcccaggacg ccagcagcgc gaacgcgtcc gcggaccgcg
     5941 ttcctggggc ggggctgtag gtcacgatct gcaagcccgc ctcgcccggc atctcgaaca
     6001 cgtcgaacga cacgtcgagg ggaccgacct cggggtgccg gaacgacttc accccggtgc
     6061 ggtgggcatg cacgtcgtgg tcggcccagt ccgtgcggaa cagcggactg cgggtggaca
     6121 gctccccgat gagcgcggtc agctcgccgt tcagcgggtc gcgcccggcc tcaaggcgca
     6181 tgaccgccgc cgtggtgcgg cgggccagcg gccagtcgac gtagtagtca ggggcgcggg
     6241 ggtcgaggaa gacgaaacgg gcgatgttcg gctggtgcgg ggtgtcgtag tgcggcgcgt
     6301 acagggcgcg gcccatgagg ttggccgcga tcaggtcctg gttcgcgttg tgcacgaggg
     6361 ccggcagcgt caggttgtcg agcacccgct ggaccgaggc ccgcaccgag cgcagggcgg
     6421 gcctctcgcc gcgcgacctg gcgggcgcgg gggcggtgcg ggccaggtcg aacaggtact
     6481 cgcgctcgac atcgttgagc tggagggcgc gcgcgatggc gttgagcacg ctctccgagg
     6541 cgccgcggat gttgccgcgc tcaagacgcg tgtagtagtc cgggctcacc ccggcgatca
     6601 tcgcgacctc ctcgcggcgc agcccgggga cgcgccgctc cccgccgacg ccggtgaggc
     6661 ccgcctgctc gggggacacg ttcgcgcggc gggagatcag gaactccctc acctcatcct
     6721 tcgtgctcat gactccaccg tagatccggt ccgcggccgg tcggggtgcc cccgggtgcc
     6781 cgcggcgcgc ccgggggccg gccgccgtca ggcggcgtcg agcgtcgcgg tgtcgatcac
     6841 gaaccggtag cggacgtcgg aggacagcac ccgctcccac gcctcgttga tccgctccgc
     6901 cgggatgatc tcgacctcgg gggcgatgcc gtgctcggcg cagaagtcga gcatctcctg
     6961 ggtctcggcg atgccgccga tcttcgaacc ggcgaaggac cgctggttct cgaacagcgt
     7021 gaacagcgtc acgggaacgg cctccggcgg ggcgccgacg ctgacgatgg tgccgccgaa
     7081 cgacagcagg gccaggtagg cgtccaggtc cagcggggcg ctgacggtgt tgatgatgag
     7141 gtcgaaggtg ttcgccagcc gcttgaacgt cgtggggtca ctggtggcgt agtagtggtc
     7201 cgcgccgaag cgcagcccgt cctcgcgctt gccgagggtc tgcgagagga ccgtcacctc
     7261 ggccctcatg gcgtgggcga tcttgaccgc catgtgcccg agcccgccca tgccgacgac
     7321 cgcgaccttc ttgcccgggc cggcgttcca gcggcgcagc ggcgagtagg tcgtgatgcc
     7381 ggcgcacagc agcggggcgg ccttctcgaa cgggatggcc tcggggacgc gcagcacgaa
     7441 gtgctcgtcc acgacgatcc ccgtggcgta cccgccctgc gtgacgcctc cgtcgcggtc
     7501 ggtcccgttg taggtgtcgg tgaagcccgc caggcagtac tgctcgcggc ccgcgcggca
     7561 gttgtcgcac tcccggcagg agtcgaccat gcagccgacc cccacccggt cgccgacccg
     7621 gtaccgcgtg acctcaggtc cgacctcggc gaccacgccg gcgatctcgt gcccgaccgt
     7681 cagcgggtag ggcacggggc cccagtcgcc gcggacggtg tggatgtcgg agtggcagat
     7741 tccggcccag tggatgtcga tgcgcacatc cttcgggccc acgtcgcgcc gctcgatcac
     7801 tccgggggcc agcggccctg cggcggaagt ggcggtgtaa gcgcgtacgg aagtcattgc
     7861 tgtcctcgcg aagacgatca tgggaaacct tgccgcgccg gtggaccggg gcgtcgcccc
     7921 cgtcctggcg cgaacggcgg tggagcgccg tcacactcca gggaaccacc gtccgcccgg
     7981 cgtccgggag gccctgagag ggcccctcac gccctgagcg gtggccggtg gccggccgct
     8041 tcccggccgg ctgccgcggc cgatctgctc gtgggattcc tcgaaaccgg tgccggcggg
     8101 aggtggtgac gccgccccgc ccggccccgt cacgcccccg cgcaccggct gcgccgcgca
     8161 ccggctgcgc cgcgcaccgg ctgcgccgcg caccggctgc gccgcgcacc ggcggcgacg
     8221 ggccggggcc ggggcgcccc ggtcaccacg ccgggagcca gccgcccgcg gtgaaggtcg
     8281 cgaagaccgc gagcatcagc aggtagagcc ccgaccagtc gatcatgcgg gtgcccagcg
     8341 gcccccggca cacccggacg gccagcaggg cggcccacgg cagcgtcacc aggggcagca
     8401 gcggacccca cgccccgaga ctgagcgccg tcagcgccag gaacccgtag cagccggcga
     8461 ggccggtgac gtacagcgcc ttcaccgccg cggacgggat caggtgcggc agggtgacct
     8521 tgcccgcctc cctgtccttg gccaggtcgc gggcgttgtt gtgcagcatc agcgtcatga
     8581 acaggaaccc gcaggcgagc gccgcgcacc agagggcggc gtcgaacgcg tcaccgttga
     8641 gccgcccgat gaccagtgtc acggccgtgc cggtgaccac gaagtccagc agctcgccga
     8701 aaccccggtg gccgagcggg cgccgcccgc cggcgtaggc gaagtaggcc gcgtacattg
     8761 gcgggatcac cagcagcagc aagggctcgg aggtgagcgc gaggacgagg aggcagaccc
     8821 acgccgccgc gaacccgccc atgccggccc accggacccg gttcatgtcc aggccgagcg
     8881 ccatcgagct gtcggggcgc acccggtcgg gcctgtccac gccgcgcctg tggtcctcga
     8941 agtcgttcac caggcgccgg ccgattccgt cgcagacgaa caggaggacc gtgagcgcga
     9001 cgcgccaccc ttcgacggcg ccctggtggc gcacggccgt cacggcgaac gccccctgga
     9061 ggaccagcac gaggaccagc ggcggccccg ccgcctgcac ccaggtccgc gccgactccc
     9121 gcgcggcggg tgtcttcgga ggaacgtcgg catccaaccg caacggccgc ctctttctca
     9181 ggtggtgaat cgggatcgcc tcgaccgggg caacgcggct ccgacggcgg gggtcagctt
     9241 tccccacccg ctcgtccgcg ggcaacatcc gccggtgcgg gcaggagcgg ttgaacgcgc
     9301 gcgtcgcgag gccgctccgc gagcccgtac gatgcggcgg cggcagcgca cgtcccctac
     9361 cgggggcggg agttaaggag tggtgtgtcc caggagcgtg tacgtcctct ggccaggccg
     9421 gtggccggcc gcagcctgcc gggcgggcgc gtcgccgacc ggctcagcct gcccccggcc
     9481 cgcatcctcg aactcctcga cgccgcgtac ccggccggcc gcgccgagag cgcgcggcgc
     9541 gtccgcgaga cgctcgcgcg cggcaagcac gcgctgctga tcaccttccg ggccggtggc
     9601 ggtcgcgtcg ccacccccgt gtgggccgcg gtggaggccg agcgggtgta cgtgcggacc
     9661 cagcgcgcct cggggaaggt cgcccgcgtc ggccgccgcc cgcaggtgct gctcggcgtg
     9721 tgctccaccc gcgggcgccc cctgaccgga gtggtgcccg ccaccgcccg ggtcctgccc
     9781 gcaggcgagg agcggcatgc cgaacgtctg ctgcaccaca ggtacggggc ggtgcgggcg
     9841 ttctgcgcga ccgcccagga cctgatgcgg gtcgacatgt gctacctgga gatcaccgtc
     9901 ggggacgaca acccggccgg gtgagcgcgg gcggcgcggt ggcagccggg agaaccacca
     9961 ggaccgcgaa gaccgcgaga acgcaacgca aggaacagtg gtgacagacc aatcgcacaa
    10021 gccgaacgac gcgcaggtgg gggcggccgt ctcggccgcc gtctccgccg ccttcgccgc
    10081 ccaggcgcag gacggcgcct ggccggggga aatcctcacg ggcgggacct cctacgaggc
    10141 cgccgacatc gtgatgcgca ccctgctcgg tgccacgacg ccgcggcacg tcgaggaact
    10201 cgccgcctgg atgctcgcgg accagaacga ggacggcggc tggtccctgt tccgcggcgg
    10261 tccctccgac ctgtcgagca gcgccttcac ccacatcgcc ctgcaactgg ccgggttccc
    10321 gctcgaccac gaggcgctgc gccgggccgc ggccttcgtg cggtccgcgg gcggccttga
    10381 ggcgatcgac atggtgccgg tgaagttctg gctcgccttc acgggcatgg tgagctggga
    10441 cgagatcccc cgcgtgccgc cggaactggt gctgctgccc tcctgggtcc ccggcgcgct
    10501 cggcgactac gagccgatgg ccagggaggt cgtcgtcgcc gtgggcatcc tgacgaccat
    10561 caggccggtg cgccgcctcg acgtggacgt caccgagttg cgcagcggcg tcccccaccc
    10621 gccgtcccgg gccgagtccg tgctgaccgg caccctgcgc gcggtgcacg cggcgacgcc
    10681 gaggacgctg cgcgccaagg ccctgcgggc gggcgaggac tggctgatgg cccggcagga
    10741 gtcggacggc agctggggcg gcagctggac ggagaccatg gtctgcgtgc tggcgctgtg
    10801 gagccggggc tacggcatcg ggcaccccgt gcagcgccgc gcgctcgccg cctgcgacga
    10861 gctgaacgtc cgggtggacg gcacccggcg ggtgcagacg ttccgcaccg tcgtgatgga
    10921 ctccgcgctc atgatgtcgg ccctggacgc caccggccgc accgacgtga gggagccgct
    10981 gcgccgcgcg ggccgctggc tcatcgacca cagggccgac acctccgtca acaccaaggg
    11041 cgtacggccc ttgcgcgcct gggacttcga gggcattccg acgatcaacg ccgacccgga
    11101 cgacacggcc atggccatca ccgccctgcg gtccgccggt gcttccgacg gcggcgcgga
    11161 cgacgaggcg gtggccgcga cctcggaggc cgcgcgctgg ctgatcgcgt gtcagtcccc
    11221 ctcgggcggc tgggccggtt tcggggtgga ccgctggtcg cgtctggggg agaaggcgct
    11281 caccggcatc ggattcgtcg agggggccac cgcctgcgtc accgcccacg ccgtcgaggc
    11341 cctgcacgcc gagggcctgg gctggcaccc cggctgccgc cgcgccgtgc gctggctgct
    11401 cgacgcgcag gacgccgacg gttcgtggcc gtcgcgctgg ggcgtcaggc tgtacggaac
    11461 gagccacgtc gtctccgcgc tgcgcacggc cggcgccccg gcgggccatc cgtcgatcgt
    11521 ggccgcccgc cgctggctgc tcgcgcacca gaaccccgac ggcggctggg gcgagaacat
    11581 cgccctcagc ctcagcgacc gccgccgcgc gaccggcgag agcagcgcca tccacaccgc
    11641 ctggtgcctg cgcggcctgc tgcgggccgg cgaggtggac gaggacgccg tcgcggccgc
    11701 ggccgggtac ctgatctccc accagaacga ggccggcacc tggaccgacc ccacggagtg
    11761 gatgatcgtc atcccggaca gcgtgtacat cagcacgccg aggatgaccc acgcgttcgc
    11821 cctctgggcg ctcgccgact accagcgcca cctctcggcg gtcgcgtcgg gcgcggcgca
    11881 cccggaccag ggaaaggcag cggaatgacc acccccttgc gcgacacgac cgagtacgac
    11941 gactggtcgg agcagtggtg ggacccgcgc ggtcccttct ccacgctctc ctggatcgcc
    12001 aggcagcggg cctctctcat tccccaggcg cccgcgggca ccggcgggac gccgctgctc
    12061 gtggacgtct gctgcggcgg cggcctgctc cacccgcaca tcgcggacaa ggggtaccgg
    12121 cacgtgggcg tggacgcgtc cgcgctcagc gccgaggtcg cccgcagccg cggcgtggac
    12181 gaagtgatcc acgcggacgt ccatcgcgtg ccgctgcccg acgggtgcgc ggacgtcgtg
    12241 gtggccgggc agtgcctgga gcacgtggac cgcccctggg aggtgatcgc cgagtgctgc
    12301 cgcctgctca agccgggcgg actcgtgatc gcggacacca tcgcggacac gctgctggcg
    12361 cggctggcga tcatcaccct ggccgagaac gtgccgctga gctggatggc gcccaagggg
    12421 tgccacgacc accggatgtt cgtcaacccg aggcggctcg cgttcgagtt cgccaggaac
    12481 ggggtgcccg tccagaccta cgggctcttt cccgacaagc gcgacctcct ggcctgggtg
    12541 ctgaaccgca ccgaccgggt caggctgcgc cgcatcgcct cgaccgacgt catctaccag
    12601 gccatcggcc gcaagccggc cgcctgagcc ggcgcgccgg gcccggcggc acaggccggg
    12661 cccggcggcg cgtcagctcc atgccagcac gacccggccg aagttgcggc cctcgtccag
    12721 gtagcgatgc gcctcggcgg cgtcctcgac gccgaacgcc cgccgttcgt ccaccaccgg
    12781 ccgcaggccg ccggccgccg ccgcccatgt cgcgtccacg tccgtgagcc tggcggtccg
    12841 cacgccgagc acgcgctggc tgcgcaggta gagcgcgcgc aggtccaggc gcgccgtgcc
    12901 cgccccgagc gcgcccgagc acaccagggc accgccgggt gccagcacgg cgggcagggc
    12961 ggcggccagt tcctgagtgg ccaggttgtc gacgaccgcg gccacgcccc tgccgtccgt
    13021 cagcgacccg accgcggcgg cgaagtcatc ggcgccgggg tcgagcgcgg cctgaacgcc
    13081 cagcgtgcgc agcgcctccc gctgccacgg ctgccgggcg caggcgagca cccgcagccc
    13141 gcggtggagc gccaccgcgc acagtgccgt gccgagtccg cccgcggctc cgttgaccag
    13201 gacccaatcg ccctgctcca cgccggcgac ctccaactgc cggtgggcca cggggccgtt
    13261 gagggccagg gcgcaggctg cgccgtcgga catgtcctcg gggacgggcc gcacgttggc
    13321 cgcgggcacg cggcagtacc cggcgtacgc gccgggccgg tgcacgccga tcagctccat
    13381 gccgccgcac agttccgtcc tgcccgcggc acacgcgtcg caccgcccgc agcagacgac
    13441 ggggaagacg gcgacccgcg tgccgagcgc gggtccgccc accccgtccc cgtgggcgac
    13501 cacctccccg acgtggtcgg cgccgagcac gtgcggcagc cgcacctgcg gggcgaacgg
    13561 cggcagcccg gcccgcgtgg cgaggtcgag ggtccgcccg acgctcacgg cccgcaccgc
    13621 gatcagcacc tccccccggc ccggtgcggg aacggggtgc cgctcggtca gttcgagtgc
    13681 cgtctccggg tctccgaagc ggcgcagcac catggagcgg gtgacggcgg gtacgcgcac
    13741 ggcggtcgag atcatgtcct tcacccggtc atcctgtcgc cgcccggccg gcgtccgcca
    13801 gggcgttcaa cggccccgcg gcggccgggg agttcgcgcg cccggccggg gccgcgggcg
    13861 cggctgcgcc ggccgggcgg acacgttcaa ctgctgccgc cgggaagcac gtcggcgggt
    13921 gggttcgtcg cgtccgtcgg tccgccaccg gtgctccggc cggagccggg cgggggtgga
    13981 agccaggtct cggtgccggc ggcgcgggcc gcgggcggtc atcaggccga cggctgccgt
    14041 tcccctcatt ggtctgtaca tggccaccgc tcgcgtcgta gcgtccggtc gaacgcgtcc
    14101 cccgccccca ccgacgaacg gacccctcat gcccctgcgc acccggcgac ggcgccacgc
    14161 ggccatgacc ggcctgctcg ccctcgccac cgccgccgcc ctcgccatcg cgccgcccgc
    14221 cgcggcggcg gacacctgga ccgaggtcgg ctccgaccgc gcccggccgc tgaccgagag
    14281 tcagggcctg acctcggtcg aggtgccggc cgacagcccc aaccgctaca ccggcatcgg
    14341 caccattcct cccgatgtcg ccctgcgcgg ctggaaccac gtcggtgacc ccgacgcctc
    14401 ctacgacggc cactacatcg agccgtacca gcgggactcg ggcagcgcca agatgttccg
    14461 cgtgcaggcg cccgacggga gctgggcgga gtacgtgcac gccctcggcc ccggcgaggc
    14521 gctcaacaac tcctgggtcg ccgtctcgcc cgacggccag tggatgctcg cgggcgagta
    14581 cggcacgatg agccggctgc tggtcttccc gaccccgggc gtcaacccgg ccacctcgcc
    14641 ctcggccgac cttccgcacg tggccaccgt ccacctcgac cggccggtgc gcgacgtcca
    14701 gggctgcgac ttctcgggtc cgacgacgct gctgtgctcg tccgacgacc cggcgggcac
    14761 cctgttcggc atgaccaagc cgctgctcca ggtcgacctc tccggcgcgc ccagcggaac
    14821 ggccgacgtc tcggggcggg tcaccgcgct gcggcagctc ccgctccgca gcggctgctc
    14881 cggcgcgttc gaggcgcagg gcgtcgacta cgaccggcgc accggcacgc tgcgcgtcat
    14941 cgtcatgtca ccgggcttct gcgtgctgac cgacagcatg acgtaccgct tcacacgcgg
    15001 ctgacgcacc gccgccgcgc gcccggcccg cgacggcggg aggggcgcgc ggcgccttgc
    15061 gggtgacgga cggccggcgg tcaccgggcc gggggcggtc gcagggtggc gggctccgtg
    15121 gtgggcagca cgaggcgcac gccgttgctc tcaagcgtgc ggtgcaccgg gggcggcggc
    15181 tcgacatccg tgaccacggc gtccagccgg tcccagccgc acagcagcac gggagcggtg
    15241 gtcgtgaact tccgccgccc gatgagcagg acgacccgtt cggctatgtc catgagggtt
    15301 tccttcacct gccgttcgac gtcggcggcg gcgtagatcc cgcgctcgtc cacgccggcc
    15361 gcccccaggt agaaggtgcg gaccttcagg cgcttggcgg tgtccacggt caacgagccg
    15421 acgagcgcgc ggctgggggc gaacaggtcg ccgccgagcg cgatgccccg tgcgctcggc
    15481 cggtccatga gcaggtcgat caccggcacg gagtgggtga ccacggtgcc gtggaacgag
    15541 tcgggcagcg cggcggccag ctggtacgcg gtggtgcccg cgtccacggc gatcacgtcg
    15601 tcgtcgcgca cgcaggtggc ggcgacccgg ccgacggtgc gcttctcctc gacgtccgcg
    15661 gcggagcggc tgctgtaggc gggcgcggag cggtcgcggg gaccggtggg cagcaccacg
    15721 ccgccccgca cggcgagcac ctcagcgtcg gcggcgagcc ggcggatgtc gcggcgggcg
    15781 gtcatctcgg agacgccgag ccgggccgcg acctccgcga tggacaggaa acccgtctcg
    15841 cgcaacgcgt cgaggatctc gtcgcggcga gcgggggccg cccggtactt cagcggatct
    15901 tgcggcacgg ctacctcgtc gcggatcggg ggcgggcgga ggcgaggccg ccgccgggcg
    15961 cggtttgaaa cgaatctaac aaacttctcc cctcgggccc agccgtgcga ccggccgtcc
    16021 cggacgtcgc gtctgcgttc aggttgttcg ctacttgaca gattattgtt gatcgggtca
    16081 atgtgttgtt gcttctagaa catttctctg tcgtatcgga acagtgaggt accgaatgtc
    16141 cgggactgag gccgccgtgg tgtgcgtcgg ggtcgtgacc ctcgacgcac tcgcgctcgt
    16201 cgatcggcat ccggacgcgg acgagcgcgt cctcgcggaa cgggtggcca tctccggcgg
    16261 cggaccggcg gcgaccgcgg ccgtggtcat ggcccggcag ggcgtgcggg tctccttcgt
    16321 gggccgcgtc ggcacggacc cggagggcga gcaggccgtg gagctgctgg cccgcgaggg
    16381 cgtcgacgtc agccgcgtgc tgcgcgaccc ggcgaccgcc acccagtcct ccgtggtcct
    16441 ggccgcgtcc ggtaccggca cccgttgcat cgccacccgc gccgttccgc cgctgcccgc
    16501 gctcgacggc ccggctgccg acctggtcgc ggacgcggac tgggtgcaca ccgaccacct
    16561 cgggttcgcc cccgtcgccg acctgctgga gcggtcggca cggccggggg cgcgccgccc
    16621 ggcgctggcc gtcgacgcgg gcaacgacgt gcccggcctc gacggccggc tcggcctggt
    16681 cgacctgtac gtgccgaccg ccgcctcgct gaccgcccgc tacggcgcca cgcgcaccac
    16741 tcccgacgcg ctcgccgact gcgccgcccg cgcactcgcc gaaggtgccg gcgcggtcgt
    16801 cgccaccagc ggcggcgaag gcagcgccgc ctggtggccg ggcggcgggc acgccgccgc
    16861 ccccgccgcc cgcggggtgg agatcgtctc caccctcggc gcgggagacg tcttccacgg
    16921 cgcgctgctc gccgccgtct gtcacggcct ggactggccc gacgcgctgc ggcacgccaa
    16981 cgccgccgcc gccctgtcct gccgcgccct cgacgggcgc ggcgcggtgc cggacctggc
    17041 cgagctgacc gccttcctgg ccgccgcccc ggccgcctga ccccatcctc gaaggagtag
    17101 gacaccgatg accgcaacga ccgacagggc cgccgtgctg gccgacatcg cccgcccgtc
    17161 cgggggcttc gcgatgctcg cggtggacca gcgcgaggcg atgcgcctga tgttcgccgc
    17221 ggccggtacg gcacccgtgc ccgaccaggt cctcaccgac ttcaaggtga aggccaccga
    17281 ggtgctctca ccccacgcct cgggcgtgct ggtggaccgg cagttcgcct acgacgcggt
    17341 actcgacgcc aaggccgtgc acccggactg cggcctgatc gtggccgccg acgccttcct
    17401 gcccggcaac ggcgtccccg tcgacgccgt ggcgatcgac gaggacgtgg acccggccgc
    17461 cgtccgcgcc cgcggcggcg ccgcgctcaa actcctcgtg ctctggcggc aggacgagga
    17521 ccccgaggag cgccgcgcga tggtcgcgga cttcaccgcg cgctgccgcg ccgccggcct
    17581 ggtcagcatc atcgaaccgg tggtgcgccc gccgcggcgc ggctgggagt tcgaccgcga
    17641 ggcggcgatc gtcgccgccg ccagggaact gggcgacagc ggcgccgacc tgtacaaggg
    17701 cgagatgccg cacggcggcg acgccgacga cgccaccctg ctgagcgcct gccgggcgat
    17761 cgacgacgcg gtggcgatgc cctgggtgat cctctcctcg ggggtcgagg ccgatctctt
    17821 cggcaacgcc gtgcgcatcg cgtgccgcgc cggcgcctcg ggattcctcg ccgggcgggc
    17881 cgtgtggaag tccgtgatcg gcgcgcggaa caccgaagcg gtgctgcgcg acgtgtccgt
    17941 gccccgcctg cgccgcctcg ccgacatcgt cgacgaggcg gtcgccgccc gctgaccccg
    18001 cccgccgggg cggccaggac gcgcccccga cccgcgctcc cggccgcccc ggcgccccgc
    18061 cccccttccg gaggtacccg cacgatgacc accgtttccc gcatcctctt caccgccccg
    18121 ggcgaggtgg cgaccgaggc gaccgaagaa ccggacgcgc cgctgccgac cggccacgtg
    18181 cggatcgcgc cgcagtacct cggcatctgc ggcagcgacc tgcacgtcct gcacggcgga
    18241 cacccgttcg ccaagccccc gctcgtgccg ggccacgagc tgtccgcggt cgtcgtcgag
    18301 accgcccccg acgtcaccgg cgtcgcggtg ggcgaccggg ccgtcatcga cccgatcatg
    18361 gcctgcggcg cgtgccgcgc ctgccgcgcc gggcggccca acctgtgcga gcccccgcgg
    18421 gtcgccggct tccgcgcccc cggcttcggc cgcacctccc acgtcgtgcc cgccgccaac
    18481 gcgcacgtcg cgcccgcctc gctgccgctc gaccggctgg cgttcgcgga acccgtggcc
    18541 tgcgccgtgc actgcctgag ccgcgtgccg aacccggccg accgcgagga cctgctcgtg
    18601 atcggcgcgg gaacgatcgg cctcacgatc gtccaggcgc tgcgcgtcag cggcgccggg
    18661 cggctgacgg tgcaggagcc cgacccggcc aagcgtgacc tcgcgcgccg gttcggcgcc
    18721 gacgtcgccg tggcgcccgg cgacctgccg gaggacgcgg cgtacaccgc ggtcatcgac
    18781 gtcgtggcgg cgcaggccac actggacgag gccaccaccc gggtgctccc cggcggcccc
    18841 gtcgtcgtca tgggcgtgcc gagcggcccc cgcgaggtgc cgctgccgtc gatgcagcgt
    18901 ttcgaacgcg acctcctcgg ctccggcatg tacgtccccg gcgacttcga caccgcgatc
    18961 gcctggctgg ccgacggcag gttccgcacg gacggcctga tcaccgacac gttctccctg
    19021 cgggaggcag ccgccgccta ccggcgggcc gccgcacccg actccatcaa ggtcctcgtg
    19081 cggctcgccg agtaacctcc gcccttacgc acgcaccgtg gaacgcacat gagcacctca
    19141 caaccggccg tcatccgccg cccgcaggat gtcgtcgacc tcgtcaacag ccaccccgcc
    19201 aagcggggcg gcacgggcgt cgcgctgatc gccctcggcg gcgtgctgat cgacgcctac
    19261 caggccgcca tggtcggctt cggcaactcc tacatcgccg acgagtacga catcagcacg
    19321 ggcgccgccg ccgcggtgaa cgccaccgtg ctcgtcgccg cactcgtcgg cgggctgatg
    19381 gcccggcccc tgatcgaacg cctcggccag cgccgcgcgt tcctgctggg catggggctg
    19441 tgcaccgtcg ccgcggcggc ggtggccttc gccccgagca tctggttcgt cctgctgtgc
    19501 cgggtggtga tgggcatcgg gctcggcatc gacttccccc tggccacctc ggcggtcgtc
    19561 gagctgtccg gctccaagag ctccaagtcc ggccgctcgg tgaacctgtg gcagatgggc
    19621 tggtacatat cgaccaccgt cgtgtacctc gtcctcctgc ccctgcacca ggccacctcc
    19681 gtggagtccg acctgtggcg gtacggcatc ttcgtcggcg ccgccttcgc cgcgctcgtc
    19741 atggtgctgc gctacgtctt catcggggag tcggcactgt gggccgcgcg ccggcaacgg
    19801 tacgacgagg ccgtgcgcat cctgcgcgag cgctacggcg tgcacgccgt ggtcgcgcac
    19861 gacgcggtcg gcgccgcccc cggctcggaa cgcccccggg tgcgcggcgc gtaccgggtc
    19921 atgttcaacc gcacctaccg gcggcgcacc gtactgggct gcgtggtcgc caccatgcag
    19981 gcgtggcagt acaacgcggt cggcatctac ctcccggtga cgctgggcgg tgtcctctcc
    20041 ggagggctcg ccggcagcct gggcggctcg gccctcgtca acgcggcctt cggcatcacc
    20101 gggggcctgc tcggctcgct gtgggtgcag cgccacggcg cccgcaagct ctccatggcc
    20161 gggttcgcgg tcgtcgcggc ctcgctcctg gtgctcggcg cgctgggttc tggtgccccc
    20221 tgggtggccc tgttcctgct cgggctcatc atcttcggcc acgcggcagg acccggcgga
    20281 ctcggcatga ccatcgccac gctgtcctac ccgcccagca tccgcccggc cggggtcggc
    20341 ttcgcccggg ccatcatgcg caccggtgcc atcgcgggac tggtgctgtg gccgatgctg
    20401 tgggacgcgc tcggcacgga cgccttcttc tggctcgccc tcgtccccgc caccggactc
    20461 atcacctgcc tgatcatccg ctgggagccc atcgggcagc cggtggacga cgaggacgcc
    20521 gacgtcctgc ggcagatcac cgtcacggaa cgcgcgacct gacgccacgg gcgcgcggac
    20581 gcccgccgcc tccccttccc accctctgtc tcccgaggag atccccatgt ccaacaccac
    20641 ccgcaacgga ccggtcatcg gcttcgtggg cgcgggcgcg atgggcggtg ccgtgtgcag
    20701 ccgcctcgcg tccggcggcc accgcgtacg cgtcttcgac ctgtcgcacg cggccgtcac
    20761 cgcgtgcgtg gccgcgggcg ccgagccggc ggcggacgcc gcggacgcgg tgcggggggc
    20821 cgacgtggtg ttcacgtcgc tgcccacgcc ggaactcgtc gcggggttct ggggcgacaa
    20881 cctgccccac ctcgcggcag gcgccgtcgc cgtggacctg tcgaccgtcg acccggccac
    20941 ctcgcgccgc gtggcggacc gcgtgacggc gcacggcgcc tcgttcgtcg cctgcaccct
    21001 gggtcgcacg ccccagcacg ccgagaacgg cgacatcccg gcgttcgtgg gcggcgagtc
    21061 cgaggcggtc gagcgggtcc gcccgctgct cgaccgcctc gcctccagcg tgcacccgct
    21121 gggcgacgtg gaggccgcga ccgcgttcaa gctgatctcc aacctcatcg gcatgaccaa
    21181 cctcgccgtc ctggccgagg ggtacgtcct ggcccgcagg gccgggatcg cgccggaggc
    21241 gttcgccgcc gcgctggagg agacgggcgc cgactcgttc cagagccggg tccggctgcc
    21301 gtggatcatg gcggacgacc tggcggcccg gttctccgtg gacctggccg cgaaggacgt
    21361 ccggctcgcc gtcgaggccg ccgcccgctg gtccgtgccc acgcccgtcg cggcggccgg
    21421 cctgtccgcc ctcgtcgcgg ccggcgcggc cggccacggc cgcagtgacg ccgcggccgt
    21481 cgtggagacc tacgacccgc gccgcaccgc gcgcggaccc gtcaccgact gatacgccgc
    21541 aggcgagtgg gcggtacccc gacgcaccgc cccctcgcct caccttcgcg actgagaggt
    21601 accccatggg tcgaggcaat ggcgcccacc ccgcccaccc cgccgacgcc ggccacgcgc
    21661 ccggtgacgg gctgcggaag gtcgtgctgg gcagtttcgc cggggccctg ctggagtggt
    21721 acgacttctt catctacggc gtggcatccg cgctcgtgtt cggcgacctc ttcttccccg
    21781 acgcggaccc ggcggtcggc acgatcgcgg ccttcgccac cttcagcatc ggcttcttcg
    21841 cccggccgct gggcggcgtc gtcttcggtc acctgggcga ccgggccggc cgccgggcgg
    21901 cgctgatc
//
