LOCUS       NZ_CP021121            21083 bp    DNA     linear   CON 31-JUL-2024
DEFINITION  Streptomyces marincola strain SCSIO 03032 chromosome, complete
            genome.
ACCESSION   NZ_CP021121
VERSION     NZ_CP021121.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces marincola
  ORGANISM  Streptomyces marincola
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6287975)
  AUTHORS   Ma,L., Zhu,Y., Zhang,W., Zhang,G., Tian,X., Zhang,S. and Zhang,C.
  TITLE     Complete genome sequence of Streptomyces sp. SCSIO 03032 revealed
            the diverse biosynthetic pathways for its bioactive secondary
            metabolites
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6287975)
  AUTHORS   Ma,L., Zhu,Y., Zhang,W., Zhang,G., Tian,X., Zhang,S. and Zhang,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2017) Key Laboratory of Tropical Marine
            Bio-resources and Ecology, South China Sea Institute of Oceanology,
            164 West Xingang Rd., Guangzhou, Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method :: Hierarchical Genome Assembly Process v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 165.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002128305.1-RS_2024_07_31
            Annotation Date                   :: 07/31/2024 06:55:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,513
            CDSs (total)                      :: 5,438
            Genes (coding)                    :: 5,343
            CDSs (with protein)               :: 5,343
            Genes (RNA)                       :: 75
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 95
            CDSs (without protein)            :: 95
            Pseudo Genes (ambiguous residues) :: 0 of 95
            Pseudo Genes (frameshifted)       :: 19 of 95
            Pseudo Genes (incomplete)         :: 88 of 95
            Pseudo Genes (internal stop)      :: 2 of 95
            Pseudo Genes (multiple problems)  :: 13 of 95
            CRISPR Arrays                     :: 12
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:29:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5711905
            Orig. end                         :: 5732988
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP021121.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Key Laboratory of Tropical
            Marine Bio-resources and Ecology.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21083
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="29"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21083
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21083
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11083](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11083)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(666..3059)
                     /locus_tag="CAG99_RS25050"
                     /old_locus_tag="CAG99_25115"
     CDS             complement(666..3059)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952838.1"
                     /locus_tag="CAG99_RS25050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_25115"
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="WP_086161514.1"
                     /transl_table=11
                     /translation="MTAAGPRADGERTAAPHAADSHDLIRVRGARENNLKDVRVDLPKR
                     RLTVFTGVSGSGKSSLVFGTIAAESQRMINETYSAFVQGFMPTLARPDADLLEGLTTAI
                     IVDQEPMAANVRSTVGTATDANALLRILFSRFGQPHIGSPNAFSFNVASLRASGAITVE
                     RGDRATVRRTYTVAGGMCPACEGMGRVSDIDPAQLYDEDKSLAEGAITVPGYKADGWSV
                     RIFTASGFLDADKPIRDYSETELHDFLHREPTKVRIENTNLTYEGLIPRVKKSFLTKSR
                     EALQPHIRAFVDRAVTFTDCPDCGGTRLNEAARSSRIAGVGIADACAMQISDLAAWVRG
                     LDEPSAAPLLGALRDLLGSLVEIGLGYLSLDRPSGTLSGGESQRVKMVRHLGSSLTDVT
                     YVFDEPTTGLHPHDIQRMNDLLLRLRDKGNTVLVVEHKPEVVAIADHVVDLGPGAGTSG
                     GEICYAGDVAGLRASGTRTGRHLDDRAALKKTVRTPTGALEIRGAAAHNLRDVDVDIPL
                     GVLVVVTGIAGSGKSSLVRESIPAGAGVVTVGQDAIRGSRRSNPATYTGLLDPIRKAFA
                     KANGVKPSLFSPNSEGACPQCNGAGVVYTDLAMMAGVATPCEECGGKRFQASVLDHRLG
                     GRDISEVLAMSVAEAEEFFAAGEARTPAAHTVLGRLADVGLGYLALGQPLTTLSGGERQ
                     RLKLATHMGEKGGVYVLDEPTTGLHLADVEQLLGLLDRLVDSGTSVIVIEHHQAVMAHA
                     DWIIDLGPGAGHDGGRIVFEGTPADLVAARSTLTGEHLAAYVGA"
     gene            complement(3056..3478)
                     /locus_tag="CAG99_RS25055"
                     /old_locus_tag="CAG99_25120"
     CDS             complement(3056..3478)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009327339.1"
                     /locus_tag="CAG99_RS25055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_25120"
                     /product="VOC family protein"
                     /protein_id="WP_086162481.1"
                     /transl_table=11
                     /translation="MDVTIHASFLPHDDPDASLAFYRDLLGFEVRDDVGYEGMRWITVG
                     PPGRPGASVVLQPPAADPGITEEERRTIVEMMAKGTYAGILLAATDLDGVFERLRAGGA
                     EIVQEPAEQPYGVRDCAVRDPAGNLIRIQEPRRDAQ"
     gene            complement(3489..3929)
                     /locus_tag="CAG99_RS25060"
                     /old_locus_tag="CAG99_25125"
     CDS             complement(3489..3929)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471798.1"
                     /locus_tag="CAG99_RS25060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_25125"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_086161515.1"
                     /transl_table=11
                     /translation="MTSRPTDARLRDLAALRRVRDRIDREYAQPLDVEALARGAHMSAG
                     HLSRAFRRAYGESPYGYLMTRRIERAMALLRRGDLSVTEVCFTVGCSSLGTFSTRFTEL
                     VGMPPSAYRRRAARATAGIPSCVAKQVTRPVRNREAQVAGRA"
     gene            4096..4641
                     /locus_tag="CAG99_RS25065"
                     /old_locus_tag="CAG99_25130"
     CDS             4096..4641
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003985011.1"
                     /locus_tag="CAG99_RS25065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_25130"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_086161516.1"
                     /transl_table=11
                     /translation="MFTWRRIEERDFPLLRSWLEQAHVRRWWNHETSAEAVARDFGPAA
                     RGEEPSEDLLAFLDGRPVGLVQRSRLCDYPAYLAELAAVVPVPDGAMTIDYLIGAPEDT
                     GRGIGTAMLRSVVARTWTEHPAAPCVLVPVVAAHRASWRALERVGLRRVGTGELEPDNP
                     VDDRTHYLYRVDRPGSGG"
     misc_feature    4990..5003
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.39"
                     /tool="antismash"
     misc_feature    complement(4991..5004)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.22"
                     /tool="antismash"
     gene            5023..6051
                     /gene="argC"
                     /locus_tag="CAG99_RS25070"
                     /old_locus_tag="CAG99_25135"
     CDS             5023..6051
                     /EC_number="1.2.1.38"
                     /GO_function="GO:0003942 -
                     N-acetyl-gamma-glutamyl-phosphate reductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070401 - NADP+ binding [Evidence IEA]"
                     /GO_process="GO:0006526 - arginine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0006592 - ornithine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1219: N-acetyl-gamma-glutamyl-phosphate reductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016639241.1"
                     /locus_tag="CAG99_RS25070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_25135"
                     /product="N-acetyl-gamma-glutamyl-phosphate reductase"
                     /protein_id="WP_086161517.1"
                     /transl_table=11
                     /translation="MVVRAAVAGASGYAGGELLRLLLGHPEVEIGALTGHANAGQPLGA
                     LQPQLGPLADRVLAPTSAESLAGHDVVFLALPHGQSGALAAQLGDETLVIDCGADFRLS
                     DAADWERFYGSPHAGTWPYGLPELPGARDALKGARRVAVPGCYPTAVTLALFPAYAARL
                     VEPEAVVVAASGTSGAGRSLKTHLLGSEVMGSMSPYGVGGTHRHTPEMIQNLSGVAGER
                     VSVSFTPTLAPMPRGILATCSAVARPGVTAARLRETYERALAAEPFVRLLPEGQWPSTA
                     AVAGSNAVAVQVALDEAAGRVIAISAVDNLTKGTAGGAVQSMNLALGLPEELGLSTIGV
                     AP"
     gene            6048..7196
                     /gene="argJ"
                     /locus_tag="CAG99_RS25075"
                     /old_locus_tag="CAG99_25140"
     CDS             6048..7196
                     /EC_number="2.3.1.1"
                     /EC_number="2.3.1.35"
                     /GO_function="GO:0004358 - glutamate N-acetyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006526 - arginine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argJ"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1220: bifunctional ornithine"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325166.1"
                     /locus_tag="CAG99_RS25075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_25140"
                     /product="bifunctional glutamate
                     N-acetyltransferase/amino-acid acetyltransferase ArgJ"
                     /protein_id="WP_086161518.1"
                     /transl_table=11
                     /translation="MSVTAAQGFTAAGVAAGIKDSGLDLALVVNQGPRSAAAGVFTSNR
                     VKAAPVLWSEQVLKGGSVTAVVLNSGGANACTGPLGFQDTHATAERAADVLGLNAAEVA
                     VASTGLIGTRLPTEKLLAGVGTAAAELTAHGGERAALAIMTTDTVHKTAVVEGEGWRVG
                     GMAKGAGMLAPGLATMLVVLTTDADVEAPVLDRALRAATRTTFDRVDSDGCMSTNDTVL
                     LLASGAAGVTPQEAEFAEAVRAVCADLALQLVKDAEGASKDIRVEVVGAATEDDALEAA
                     RSIARNNLLKCAVHGEDPNWGRVLAAIGTTSAAFEPDRLAVAINGVWVCRDGSIGEDRS
                     LVDMRYREVTITADLGAGDASVVVWTNDLTADYVHENSAYSS"
     gene            7193..8110
                     /gene="argB"
                     /locus_tag="CAG99_RS25080"
                     /old_locus_tag="CAG99_25145"
     CDS             7193..8110
                     /EC_number="2.7.2.8"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0003991 - acetylglutamate kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006592 - ornithine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1174: acetylglutamate kinase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019435049.1"
                     /locus_tag="CAG99_RS25080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_25145"
                     /product="acetylglutamate kinase"
                     /protein_id="WP_086161519.1"
                     /transl_table=11
                     /translation="MTHAPARKHTALPKARILIEALPWLTRHHGKTVVIKFGGNAMVDD
                     DLKAAFAQDVAFLRHAGLRPVVVHGGGPQITAQLERLGLTSEFRAGLRVTTPETMDVVR
                     MVLAGQVQRELVGLLNRHGPLAVGMTGEDARLMSAVRRYADVDGERVDIGRVGDVTEVD
                     TGAVRALLDDGRVPVISSIARSADDESVYNVNADTAAAALAAALGAETLMVLTDVEGLY
                     ADWPASDEVISRLTESQLEKLLPDLASGMVPKMEGCLFAVRNGVRTARVIDGRVQHSIL
                     LEIFTDEGIGTMVVPDAAAKGEPT"
     gene            8107..9330
                     /locus_tag="CAG99_RS25085"
                     /old_locus_tag="CAG99_25150"
     CDS             8107..9330
                     /EC_number="2.6.1.11"
                     /GO_function="GO:0008483 - transaminase activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0006525 - arginine metabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (35-347). E-value: 2.4e-98.
                     Score: 321.2. Matches aSDomain:
                     nrpspksdomains_CAG99_RS25085_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018836812.1"
                     /locus_tag="CAG99_RS25085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_25150"
                     /product="acetylornithine transaminase"
                     /protein_id="WP_086161520.1"
                     /sec_met_domain="Aminotran_3 (E-value: 6.1e-108, bitscore:
                     359.4, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNAPAHSAPAAGNASFAARWRGALMDNYGTPRLALTHGEGSRLW
                     DADGNAYLDFVGGIAVSSLGTGHPAVVRAVSEQIARLGHVSNLYIAEPPVALAERLLGL
                     AGRPGRVFFSNSGAEAVEAAFKIGRLTGRPHMVATEGGFHGRTMGALALTGQPKKQEGF
                     GPLPGEVTHVPYGDADALRAAVTERTALVIIEPVQGENGVVVPPEGYLTAAREITRATG
                     TLLVLDEVQTGIGRTGHWFAGQAEGVEPDLVTLAKGLGGGLPIGATLAFGVAAELLAPG
                     GHGSTFGGNPVACAAALAVLDTIESEHLLQRVKEAGERLRDGIWRLGHPLVDRVRGAGL
                     LLGIVLTEPRAPQAQQAAQDAGLLVNAVAPDVLRLAPPLIIGDAEIDAFLTALPGVLDI
                     VDTASGER"
     aSDomain        8212..9147
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CAG99_RS25085_Aminotran_3.1"
                     /evalue="2.40E-98"
                     /label="CAG99_RS25085_Aminotran_3.1"
                     /locus_tag="CAG99_RS25085"
                     /protein_end="347"
                     /protein_start="35"
                     /score="321.2"
                     /tool="antismash"
                     /translation="LTHGEGSRLWDADGNAYLDFVGGIAVSSLGTGHPAVVRAVSEQIA
                     RLGHVSNLYIAEPPVALAERLLGLAGRPGRVFFSNSGAEAVEAAFKIGRLTGRPHMVAT
                     EGGFHGRTMGALALTGQPKKQEGFGPLPGEVTHVPYGDADALRAAVTERTALVIIEPVQ
                     GENGVVVPPEGYLTAAREITRATGTLLVLDEVQTGIGRTGHWFAGQAEGVEPDLVTLAK
                     GLGGGLPIGATLAFGVAAELLAPGGHGSTFGGNPVACAAALAVLDTIESEHLLQRVKEA
                     GERLRDGIWRLGHPLVDRVRGAGLLLGIVLT"
     gene            9347..9931
                     /locus_tag="CAG99_RS25090"
                     /old_locus_tag="CAG99_25155"
     CDS             9347..9931
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0006525 - arginine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004002600.1"
                     /locus_tag="CAG99_RS25090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_25155"
                     /product="arginine repressor"
                     /protein_id="WP_086161521.1"
                     /transl_table=11
                     /translation="MTEESGSTAASPRARAASSAAGPAVPQTRAARHRRIVDILNRQPV
                     RSQSQLAKLLADDGLTVTQATLSRDLDELGAVKIRNTGGELIYAVPSEGGYRTPRVPLG
                     ESAKEERMARLAGELLISAEASANLVVLRTPPGAAQFLASAIDQAEVHDILGTIAGDDT
                     LLLISRDPVGGQSLADHLLRLAQKGKEEPEG"
     gene            complement(10001..11083)
                     /locus_tag="CAG99_RS25095"
                     /old_locus_tag="CAG99_25160"
     CDS             complement(10001..11083)
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019435052.1"
                     /locus_tag="CAG99_RS25095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_25160"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_086161522.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 6.2e-54, bitscore:
                     181.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTVPHTADEHHTALDSLRRARELLDPALRTWVHRLPAPVARVAS
                     YHFGWTDAEGRPDSAPAGKALRPALVFGCAEAVGAAPEDAVGPAVAVELVHNFSLLHDD
                     ILDGDTTRRHRATAWSVFGSSAALLAGDALLIHAGRVLTEQPAGLASLTGIRWLSEATT
                     QLIEGEQTDISFEERTRVTLAECLAMTERKTAALLACSCALGALWGGGSPEAIEAMRRF
                     GTHLGMAFQLTDDLLGIWGDPAVTGKPAGADLVSRKKSLPVVAALDSGTPAARRLAELY
                     LPGGGAPGADGGPGRQAPEPELTARLAGLVEEAGGRAWAEQAAEEELRLALQCLDAARP
                     EPAAGERLAALARLACRRDR"
     misc_feature    complement(11345..11356)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            complement(11752..12318)
                     /locus_tag="CAG99_RS25105"
                     /old_locus_tag="CAG99_25170"
     CDS             complement(11752..12318)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966087.1"
                     /locus_tag="CAG99_RS25105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_25170"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_086161524.1"
                     /transl_table=11
                     /translation="MLSHPLGPEARLGALEPWQAEEFAAYTDRARDHLAPWLPWTRSVT
                     DADSARRFLRRFAETQAADGPRLYGIWLSGELVGGMMYRLFDARQGSCELGAWLSPGAE
                     GRGLVTGAATAMIDWAVRTRGLARVEWLVSPDNVRSIAVARRLGMTHEGTLRSVFEMDG
                     KRHDLEVWAVLGEEWRQRAAPHPIG"
     misc_feature    complement(12540..12558)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.21"
                     /tool="antismash"
     gene            12583..13779
                     /locus_tag="CAG99_RS25110"
                     /old_locus_tag="CAG99_25175"
     CDS             12583..13779
                     /EC_number="6.3.4.5"
                     /GO_function="GO:0004055 - argininosuccinate synthase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006526 - arginine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1291: argininosuccinate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018836804.1"
                     /locus_tag="CAG99_RS25110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_25175"
                     /product="argininosuccinate synthase"
                     /protein_id="WP_086161525.1"
                     /transl_table=11
                     /translation="MTQRVVLAYSGGLDTSVCIGWIAEATGAEVVAVAVDVGQGGESLD
                     VIRKRALACGAVEAEVVDAKDEFAQEYCLPAIKANGLYMDRYPLVSALSRPVIVKHLVA
                     AARKHGADTVAHGCTGKGNDQVRFEAGISSLAPDLTCIAPVRDYAMTRDKAIAFAESKG
                     LPIATSKKSPYSIDANVFGRAIETGFLEDIWNGPIEDIYEYTQNPATPREADEVVITFE
                     RGVPVAIDGRAVSVLQAVQELNERAGAQGVGRIDIVEDRLVGIKSREVYEAPGAIALIT
                     AHQELENVTVERELARYKRQVEQRWSELVYDGLWYSPLKRALDGFVEEANEHVSGDIRM
                     TLHGGRAVVTGRRSGESLYDFSLATYDTGDTFDQSQAKGFIDIFGLSTKIAARRDLAQ"
     gene            13776..15218
                     /gene="argH"
                     /locus_tag="CAG99_RS25115"
                     /old_locus_tag="CAG99_25180"
     CDS             13776..15218
                     /EC_number="4.3.2.1"
                     /GO_function="GO:0004056 - argininosuccinate lyase activity
                     [Evidence IEA]"
                     /GO_process="GO:0042450 - arginine biosynthetic process via
                     ornithine [Evidence IEA]"
                     /codon_start=1
                     /gene="argH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006607537.1"
                     /locus_tag="CAG99_RS25115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_25180"
                     /product="argininosuccinate lyase"
                     /protein_id="WP_086161526.1"
                     /transl_table=11
                     /translation="MSENQPEVRLWGGRFAHGPAEALERLSASVHFDWRLAPYDIAGSR
                     AHARVLHRAGLLTAEELDRMLAGLDRLAADVESGAFTGTVADEDVHTALERGLIERLGP
                     ELGGKLRAGRSRNDQVATLFRMYLRDHARIIAGLLAELQGALIGLAEAHPDVPMPGRTH
                     FQHAQPVLFSHHVLAHVQALGRNAERLRQWDARTAVSPYGSGALAGSSLGLDPEAVARD
                     LGFEGGSAANSIDGTSSRDFVAEFAFITAMAGVDISRIAEEVIVWNTKEFSFVTLHDSF
                     STGSSIMPQKKNPDIAELARGKSGRLIGNLTGLLATLKALPLAYNRDLQEDKEPVFDSC
                     DQLEILLPAFTGMIATLKVNRERMAELAPAGFSLATDVAEWLVKRGVPFRVAHEVAGEC
                     VRVCEAEGIELDALTDEQFAKISPHLTPEVRTVLTVEGALAARDARGGTAPAAVAVQLR
                     EAKDDLARQLEWARRSPGPVAG"
     gene            complement(15267..16280)
                     /locus_tag="CAG99_RS25120"
                     /old_locus_tag="CAG99_25185"
     CDS             complement(15267..16280)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005318374.1"
                     /locus_tag="CAG99_RS25120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_25185"
                     /product="Gfo/Idh/MocA family protein"
                     /protein_id="WP_086161527.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 7.8e-25, bitscore:
                     86.2, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 2.3e-26,
                     bitscore: 90.5, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADGGKGGAVAADRPVRWGILATGGIAAKLAGDLADLPDAEVAAV
                     ASRAPGPAAEFARRFDIPRSHGSWADLAADPDVDVVYVATPHSAHHAATRLCLEAGKPV
                     LCEKPFTLTAAEAKDLVGLARSRGVFLMEAMWMNCNPVIRRMADLVRDGAIGEIRTVHA
                     DFGIGGPLDPGHRLLDPALGGGALLDLGVYPVSFAHLLLGEPSEVAAWARLRDGVDENT
                     GMLLGHASGAVAALTCSLVADTARTASVTGTGGRIEFPRGFFHPERFVLHRDGREPEEF
                     SGPGPAGSFAHQAAEVMRCLRAGETESPLVPLDDSLAVMRTLDAVRDRIGLRYPGE"
     misc_feature    complement(16325..16334)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.45"
                     /tool="antismash"
     gene            16477..17301
                     /locus_tag="CAG99_RS25125"
                     /old_locus_tag="CAG99_25190"
     CDS             16477..17301
                     /NRPS_PKS="Domain: Abhydrolase_1 (34-129). E-value:
                     2.6e-19. Score: 61.7. Matches aSDomain:
                     nrpspksdomains_CAG99_RS25125_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005317055.1"
                     /locus_tag="CAG99_RS25125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_25190"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_086161528.1"
                     /sec_met_domain="PF00561 (E-value: 1.7e-13, bitscore: 49.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 5e-21, bitscore:
                     74.6, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGSTVENEPSVPLRYADVRGLRLAYADFGGTGRPLLALHGHFGR
                     ARMFAPLAAALGSGHRVIALEQRAHGASGRDGDVRPDAYLEDAAAFLRDLGAGPAVVLG
                     HSAGGVTAFRLAARHPELVAALIVEDHGALNRQPDVAHPVLDISGWPRRTGSLAGLRRA
                     VEAHGIPDAGYFLESATEYEDGWGFLFDHDQLMESQRLLMGDWWPDWLASTCPALLIHG
                     TESFVLPTAMAHAMAERRPRTTLREFPGRGHWVHDEDPEGFARAVADFLATL"
     aSDomain        16579..16863
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CAG99_RS25125_Abhydrolase_1.1"
                     /evalue="2.60E-19"
                     /label="CAG99_RS25125_Abhydrolase_1.1"
                     /locus_tag="CAG99_RS25125"
                     /protein_end="129"
                     /protein_start="34"
                     /score="61.7"
                     /tool="antismash"
                     /translation="PLLALHGHFGRARMFAPLAAALGSGHRVIALEQRAHGASGRDGDV
                     RPDAYLEDAAAFLRDLGAGPAVVLGHSAGGVTAFRLAARHPELVAALIVE"
     CDS_motif       16765..16830
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CAG99_RS25125_0001"
                     /evalue="3.00E-06"
                     /label="NRPS-te1"
                     /locus_tag="CAG99_RS25125"
                     /protein_end="118"
                     /protein_start="96"
                     /score="19.8"
                     /tool="antismash"
                     /translation="AGPAVVLGHSAGGVTAFRLAAR"
     gene            complement(17354..18259)
                     /locus_tag="CAG99_RS25130"
                     /old_locus_tag="CAG99_25195"
     CDS             complement(17354..18259)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (17-188). E-value: 3.9e-26.
                     Score: 83.8. Matches aSDomain:
                     nrpspksdomains_CAG99_RS25130_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008413531.1"
                     /locus_tag="CAG99_RS25130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_25195"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_086161529.1"
                     /sec_met_domain="ADH_N (E-value: 5.1e-05, bitscore: 21.4,
                     seeds: 66, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAIRIARFGGPEVLGVVDAPQPEQGAGDVLIRTVATSINPVDDK
                     TREGAIGKGTPPLPMTLGWDLAGIVVDGGSSDLRPGERVIAMSHQLSTGRGTWADLVVL
                     PAHALAPAPQAVSLVEAATLPLPGLTALQTLDWLSLSAGERLLIAGAAGAVGGLALQIA
                     HARGLQVDALVSRDEHTRFARTHGAELATTDRNALQDRSYDAVFDTFGAFVTEAVADGG
                     RYASIATQAGPVPDLSSRDVRTTVNQVREDGIGLGRLTKLVDRGSLRLRVHSAYGLHEI
                     RTAHERFAQGGLEGKITVTF"
     aSDomain        complement(17696..18208)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CAG99_RS25130_PKS_ER.1"
                     /evalue="3.90E-26"
                     /label="CAG99_RS25130_PKS_ER.1"
                     /locus_tag="CAG99_RS25130"
                     /protein_end="188"
                     /protein_start="17"
                     /score="83.8"
                     /tool="antismash"
                     /translation="VDAPQPEQGAGDVLIRTVATSINPVDDKTREGAIGKGTPPLPMTL
                     GWDLAGIVVDGGSSDLRPGERVIAMSHQLSTGRGTWADLVVLPAHALAPAPQAVSLVEA
                     ATLPLPGLTALQTLDWLSLSAGERLLIAGAAGAVGGLALQIAHARGLQVDALVSRDEHT
                     RFARTHGA"
     CDS_motif       complement(17771..17833)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CAG99_RS25130_0001"
                     /evalue="2.60E-04"
                     /label="PKSI-ER_m5"
                     /locus_tag="CAG99_RS25130"
                     /protein_end="163"
                     /protein_start="142"
                     /score="13.7"
                     /tool="antismash"
                     /translation="GERLLIAGAAGAVGGLALQIA"
     gene            <18384..>18676
                     /locus_tag="CAG99_RS29100"
                     /old_locus_tag="CAG99_25200"
                     /pseudo=""
     CDS             18384..>18676
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007383435.1"
                     /locus_tag="CAG99_RS29100"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="CAG99_25200"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPPVWLWSSETGATSKDVDRCRQAFLRRFDPEHTFRFVQRTPG"
     gene            18779..19750
                     /locus_tag="CAG99_RS25140"
                     /old_locus_tag="CAG99_25205"
     CDS             18779..19750
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018103826.1"
                     /locus_tag="CAG99_RS25140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_25205"
                     /product="aldo/keto reductase"
                     /protein_id="WP_086162482.1"
                     /transl_table=11
                     /translation="MAFSRFTPAATGAARIGLGLAAVGRPGYINLGRARDLPAPRTPEA
                     LRARTHQLLDAAHAAGVRYLDTARSYGRAEEFLADWLTGRPEAADVVVGSKWGYTYTAD
                     WRADADVHEVKDHGAAMFDRQWAESRALLGGRLDLYQIHSATQDSGVLADPAVLDRLAR
                     LADTGVDVGLSTSGPRQAETIRAALEVERGGRPLFRTVQATYNVLEQSAAPALAEAHAA
                     GRTVIVKEALANGRLAGPEAPGELREVADATGTGPDAVALAAVLAQPWTGIVLSGAATE
                     GQLADNLAAARLRLDAAHLEAFTRLAEPSDAYWRARSALPWT"
     gene            complement(19778..20458)
                     /locus_tag="CAG99_RS25145"
                     /old_locus_tag="CAG99_25210"
     CDS             complement(19778..20458)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141: acyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016905432.1"
                     /locus_tag="CAG99_RS25145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_25210"
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase"
                     /protein_id="WP_086161530.1"
                     /transl_table=11
                     /translation="MSRFVLLKVLLGPLLKLFFRPRVEGIRQIPADGPVILAGNHLTFI
                     DSIILPLVMERQVFFIGKDEYVKGRSLRGRLMAWFFTAVGMIPVDRDGGHGGVAALMTG
                     RRVLEEGKVFGIYPEGTRSPDGRLYRGRTGIARLTLMTGAPVVPFAMIGTDRVQPGGRG
                     LPRVGRGRRITVRFGQPLDFSRYEGMDRDRYVLRAVTDEVMTEVMRLSGQEYVDMYATK
                     AKAA"
ORIGIN
        1 ccgtgggagc ttgagtcgcg gaagtgaacc gcctccattt ccaggtcgtg cagggtcacg
       61 ccggtgatgt ggacgtggtc ggaggcgtcc atgacgatgc ccttctggcc gccggtgacg
      121 gtgaagccgg acaggttcca gtgggcggcg ccgtcgaggt gcagtccgta gccgccgcgg
      181 gcggtcagca cggcgccggc cggacccgtc agcgtgatgg gggcgtcggc ggtgccgtcc
      241 gcggtggcgt cgaaattgcc ccggtaagtg ccggccgcga ggcggatcgt gtccccgggc
      301 gaggcgtcgg ccagggccgc cgccaactgc tcggcgtccg tcacctcgac gacggccgcc
      361 gcgtctgcgg cggcggcggg cggggacagc gccgtcagca ggccggccgc gcacacggcg
      421 gcgcacgcgt gcggacggcg ggcggtggcg cgggcggggc ggacgggcat gacgctcctt
      481 cacacgacgg cggccgggcg cgggcgcgcg ggcccgggag gagaaacgac gctcaggaac
      541 cggaacctac gaacgccgcc cgggaccgtc aaggcgggcg cggcccagtg gcggggcgca
      601 cgccgccggg gcgcggtcgt cccgaacggc agccgcggcc ggccggcggg tgccgggccc
      661 ggccgtcagg cgccgacgta ggccgcgagg tgctcgccgg tgagggtgga ccgggcggcg
      721 acgagatcgg cgggcgtgcc ctcgaacacg atccggccgc cgtcgtggcc ggccccggga
      781 ccgaggtcga tgatccagtc ggcgtgcgcc atgaccgcct ggtggtgctc gatgacgatc
      841 accgacgtgc cggagtcgac gaggcggtcg agcaggccga gcaactgctc gacatcggcg
      901 aggtggagcc ctgtggtcgg ctcgtcgaga acgtacacac cgcccttctc gcccatgtgg
      961 gtggccagtt tgagccgttg ccgttcaccg cccgacagcg tggtgagcgg ctggccgagc
     1021 gccaggtagc ccagccccac atcggcgagc cggccgagga cggtgtgcgc ggcgggggtg
     1081 cgcgcctcgc ccgcggcgaa gaactcctcg gcctcggcca ccgacatcgc gagcacctcg
     1141 ctgatgtccc gcccgccgag gcgatggtcg agcaccgacg cctggaaccg cttcccgccg
     1201 cactcctcgc acggggtggc gacgccggcc atcatcgcca ggtcggtgta gacgacgccg
     1261 gccccgttgc actgcggaca ggcgccctcg gagttggggc tgaacagaga cggcttgaca
     1321 ccgttcgcct tggcgaacgc cttgcggatc gggtcgagca gccccgtgta ggtcgcgggg
     1381 ttgctgcgcc gcgagccgcg gatcgcgtcc tggccgaccg tcaccactcc cgcgcccgcc
     1441 gggatcgact cgcgcacgag cgaactcttg cccgagcccg cgatcccggt gaccaccacg
     1501 agcaccccga gcgggatgtc cacgtcgaca tcgcgcaggt tgtgcgcggc ggcgccccgg
     1561 atctccaggg cgccggtggg cgtccgcacc gtcttcttga gcgccgcccg gtcgtcgagg
     1621 tggcggccgg tcctggtgcc cgacgcgcgc agcccggcca cgtcccccgc gtagcagatc
     1681 tcgccgcccg aggtgccggc gccggggccg aggtcgacga cgtggtcggc gatggcgacg
     1741 acctcgggtt tgtgctcgac gaccagcacc gtgttgccct tgtcgcgcag ccgcagcagc
     1801 aggtcgttca tccgctggat gtcgtgcggg tgcaggccgg tggtgggctc gtcgaacacg
     1861 tacgtgacgt cggtgaggct ggacccgagg tggcggacca tcttcacgcg ctgcgactcg
     1921 ccgcccgaca gcgtgccgga cggccggtcg agcgagaggt agccgagccc gatctccacc
     1981 agcgagccga gcaggtcgcg cagcgcgccg agcagcggag cggcggacgg ctcgtcgaga
     2041 ccgcgcaccc acgcggccag gtcgctgatc tgcatcgcgc aggcgtcggc gatgccgacc
     2101 ccggcgatcc gggaggaacg ggccgcctcg ttgagccgcg tgccgccgca gtcggggcag
     2161 tcggtgaacg tgacggcgcg gtccacgaac gcccggatgt gcggctgcaa cgcctcccgg
     2221 ctcttggtga ggaacgactt cttgacccgg gggatgagcc cttcgtaggt caggttggtg
     2281 ttctcgatcc gcaccttggt cggctcgcgg tggaggaagt cgtgcagctc ggtctccgag
     2341 tagtcccgga tcggcttgtc cgcgtcgagg aaccccgagg cggtgaagat gcgcaccgac
     2401 cagccgtccg ccttgtagcc gggaacggtg atggcgccct cggcgagcga cttgtcctcg
     2461 tcgtagagct gggccgggtc gatgtcgctc acccggccca tgccctcgca ggccgggcac
     2521 atgcccccgg cgaccgtgta ggtccggcgc acggtcgcgc ggtcaccgcg ctcgacggtg
     2581 atcgcgccgc tcgcccgcag cgaggcgacg ttgaaggaga acgcgttggg cgagccgatg
     2641 tgcggctgcc cgaaccggct gaacaggatg cggagcaggg cgttggcgtc ggtggccgtg
     2701 ccgaccgtgg agcggacgtt ggccgccatc ggctcctggt cgacgatgat cgcggtggtc
     2761 agcccttcga gcaggtcggc gtcgggtcgc gcgagcgtcg gcatgaagcc ctggacgaag
     2821 gcgctgtacg tctcgttgat cattcgctgc gactccgcgg cgatcgtgcc gaagaccagc
     2881 gagctcttgc ccgaccccga gacaccggtg aacacggtca gccggcgctt ggggaggtcg
     2941 acgcggacgt ccttcaggtt gttctcgcgc gcgccccgca cccggatcag gtcgtggctg
     3001 tcggcggcgt gcggcgcggc cgtccgttcg ccgtccgcgc gcggcccggc cgcggtcact
     3061 gggcgtcccg gcggggctcc tggatgcgga tcaggttgcc cgcggggtcg cggacggcgc
     3121 agtcgcgcac gccgtacggc tgctcggcgg gctcctgcac gatctcggcg cccccggccc
     3181 gcaaacgttc gaagacgccg tcgaggtcgg tggccgccag gaggatgccg gcgtaggtgc
     3241 ccttggccat catctcgacg atggtgcgcc gttcctcctc ggtgatgccc gggtcggccg
     3301 cgggcggttg caggacgacg gaggcgccgg gccggccggg gggaccgacg gtgatccagc
     3361 gcatgccctc gtagccgacg tcgtcgcgca cctcgaaacc gaggaggtcg cggtagaagg
     3421 cgagggaggc gtccgggtcg tcgtgcggga ggaaactggc gtgaatggtg acgtccatgg
     3481 cggccacgtt aggcgcggcc cgccacctgc gcttctcgat tcctgaccgg tcgggtcacc
     3541 tgcttcgcca cgcacgacgg gatgcctgcc gtcgcccggg ccgcccggcg cctgtaggcg
     3601 ctcggcggca tcccgaccag ctcggtgaac cgggtgctga aggtgccgag cgaggagcag
     3661 ccgacggtga agcagacctc ggtgacgctc aggtcgccgc gccgcagcag cgccatcgcg
     3721 cgctcgatgc gccgcgtcat caggtagccg tacggcgact cgccgtaggc gcgccggaac
     3781 gcgcggctga ggtgtccggc cgacatgtgc gcgccgcggg cgagcgcctc cacgtccagc
     3841 ggctgcgcgt actcccggtc gatgcggtcg cggacgcggc gcagtgcggc gaggtcgcgc
     3901 agccgcgcgt cggtcggtct gctggtcacc cggcgatcgt gccacggcgc gccgcgcgtg
     3961 ccgagtgcgg cccgtgccgg tgcggcccgc ccgttccggt gcggccggga cccgcgtgcg
     4021 cccgggaccg gccgaggcgc gtagcctccg gaggggcgtg cgctggcgcg cggctgtcgc
     4081 aggagggggc tcgcggtgtt cacgtggcgt cggatcgagg aacgggactt tccgctgctg
     4141 cggtcatggc tggagcaggc ccacgtgagg cgctggtgga accacgagac ctcggcggag
     4201 gcggtggcgc gcgacttcgg ccccgcggcc cggggggagg agccctccga ggaccttctc
     4261 gcgttcctcg atggccgccc ggtcggcctg gtgcagcgtt cacgcctgtg cgactacccc
     4321 gcgtacctgg ccgagttggc ggccgtcgtc ccggtgcccg acggcgcgat gaccatcgac
     4381 tacctgatcg gcgcgcccga ggacaccggc cggggcatcg ggacggcgat gctccgctcc
     4441 gtcgtcgcgc ggacgtggac cgagcacccg gccgccccgt gcgtcctcgt tcccgtggtg
     4501 gcggcccatc gcgcttcgtg gcgcgcgttg gagagggtgg ggctgcgcag ggtcggcacc
     4561 ggggagctgg agccggacaa cccggtcgac gaccggaccc actacctcta ccgcgtcgac
     4621 cggccgggaa gcggaggctg acggggcggc ggcgccgccg cgctccggcg tccggccgga
     4681 ccgtcgcggc atccgttccc gtggtccgtg gtccgtggtc cgtgggcacg ggaacgggtc
     4741 cggtgcgtcg gatgggttct cgcgcacgtt ccggcggccc tgccgaatgg gccggcggcc
     4801 ggtgcggctg cgggcgtgcc gcgccggacg cggacgcacc agagggccga gtccaccgtg
     4861 cgggcgcgca gcagggccat cacgctcagc cccgcaccaa ctcgaccgct cacccgccag
     4921 gtgaagcgcc cggtcgcagg tgccgaccgc ctcccgcccc gggcaccatt gcataaaact
     4981 gccatgctgc gtatagtcat gctactcact cttgaggagg cgatggtcgt gcgagctgcg
     5041 gtggcgggag cgagtggcta cgcgggaggg gaactcctgc ggctgctgct gggacatccc
     5101 gaggtcgaga tcggggcgct gaccggtcat gccaacgcgg ggcagcccct cggggcgctc
     5161 cagccgcagc tggggccgtt ggccgaccgg gtgctggcgc cgacctcggc cgagtccctg
     5221 gccggacacg acgtcgtgtt cctcgccctg ccgcacgggc agtccggggc cctggcggcg
     5281 cagctcgggg acgagacgct ggtcatcgac tgcggcgccg acttcaggct gtccgacgcg
     5341 gccgactggg aacggttcta cggttccccg cacgcgggga cctggcccta cgggctgccc
     5401 gagctgcccg gcgcacggga cgcgctcaag ggcgcccggc gcgtcgcggt ccccggctgc
     5461 tacccgacgg ccgtgaccct ggccctgttc cccgcctacg ccgcccgcct cgtcgagccc
     5521 gaggccgtcg tcgtcgccgc gagcggcacc tcgggcgcgg ggcgttccct caagacccac
     5581 ctgctcggca gcgaggtcat ggggtccatg agcccctacg gcgtcggcgg cacgcaccgc
     5641 cacacgcccg agatgatcca gaacctctcc ggcgtcgcgg gggagcgggt gtccgtctcg
     5701 ttcaccccga cgctcgcccc catgccccgc ggcatcctcg ccacctgctc ggccgtggcg
     5761 cgccccggcg tcaccgcggc ccggctgcgg gagacctacg aacgggcgct ggccgccgag
     5821 ccgttcgtcc ggctgctgcc cgagggacag tggccgagca cggccgccgt cgccggctcc
     5881 aacgcggtcg cggtccaggt cgccctcgac gaggccgccg ggcgcgtcat cgcgatcagc
     5941 gccgtcgaca acctcaccaa gggcaccgcg ggcggcgcgg tgcagagcat gaacctcgcc
     6001 ctgggcctcc cggaggaact gggcctctcg acgatcggag tggcgccgtg agcgtgaccg
     6061 cagcacaggg attcaccgcg gccggtgtcg ccgccggcat caaggacagc ggcctcgacc
     6121 tggccctcgt cgtcaaccag gggccgcgct ccgcggcggc cggcgtcttc accagcaacc
     6181 gtgtcaaggc cgcccccgtc ctgtggtcgg agcaggtgct caagggcggc agcgtgacgg
     6241 ccgtcgtgct caactccggc ggcgccaacg cctgcacggg cccgctcggc ttccaggaca
     6301 cccacgccac cgcggaacgc gccgccgacg tgctcggact gaacgcggcc gaggtggccg
     6361 tggcctccac cggcctgatc ggcaccaggc tgccgaccga gaagctgctc gccggggtcg
     6421 gcaccgcggc cgccgagctg accgcgcacg gcggtgagcg cgccgcactc gccatcatga
     6481 cgaccgacac cgtgcacaag accgccgtcg tcgagggcga gggctggcgc gtcggcggca
     6541 tggccaaggg cgcgggcatg ctggctcccg gcctggcgac catgctggtc gtgctcacca
     6601 ccgacgccga cgtggaggcg cccgtgctcg accgcgcgct gcgcgccgcc acccgcacca
     6661 ccttcgaccg cgtcgactcc gacggctgca tgtccaccaa cgacacggtg ctgctgctgg
     6721 cctcgggcgc cgccggcgtc acgccgcaag aggccgagtt cgccgaggcc gtgcgcgccg
     6781 tctgcgcgga cctcgcgctc cagctcgtca aggacgcgga aggcgcgtcc aaggacatcc
     6841 gcgtcgaggt cgtcggcgcg gccaccgagg acgacgccct ggaggcggcc cgctccatcg
     6901 cccgcaacaa cctcctcaag tgcgcggtcc acggcgagga ccccaactgg ggccgggtgc
     6961 tcgcggccat cggcaccacc tcggccgcgt tcgagcccga ccggctcgcc gtcgcgatca
     7021 acggggtctg ggtctgccgg gacggctcca tcggcgagga ccgctccctg gtcgacatgc
     7081 gctaccgcga ggtcacgatc accgccgacc tcggcgcggg cgacgcgtcg gtcgtcgtct
     7141 ggaccaacga cctcaccgcc gactacgtcc acgagaacag cgcctactcc tcatgaccca
     7201 cgcccccgcc cgcaaacaca ccgcgctgcc caaggcgcgc atcctcatcg aggccctgcc
     7261 ctggctgacc cgccaccacg gcaagaccgt cgtcatcaag ttcggcggca acgccatggt
     7321 cgacgacgac ctgaaggccg cgttcgccca ggacgtcgcg ttcctcaggc acgcgggact
     7381 gcgccccgtc gtcgtgcacg gcggcggacc gcagatcacg gcgcagctgg aacggctggg
     7441 cctgacctcc gagttccgcg ccggtctgag ggtgacgacc cccgagacca tggacgtggt
     7501 gcgcatggtg ctggccggcc aggtccagcg cgaactggtc gggctgctga accggcacgg
     7561 accgctggcc gtcggcatga cgggcgagga cgcccggctg atgtccgcgg tgcgccgcta
     7621 cgccgacgtc gacggggagc gggtcgacat cggccgcgtc ggcgacgtca ccgaggtgga
     7681 cacgggagcc gtccgcgcgc tgctcgacga cggccgcgtt ccggtcatct cctccatcgc
     7741 ccgcagcgcc gacgacgaga gcgtctacaa cgtcaacgcc gacaccgccg ccgccgcgct
     7801 ggccgccgcc ctcggcgcgg agaccctgat ggtgctgacg gacgtcgagg gcctgtacgc
     7861 cgactggccg gcgagcgacg aggtgatcag ccggctcacc gagagtcagc tggagaagct
     7921 gctgcccgac ctggccagcg gcatggtgcc gaagatggag ggctgcctct tcgcggtccg
     7981 caacggcgtg cggaccgcgc gcgtcatcga cggccgggtc cagcactcca tcctgctgga
     8041 gatcttcacg gacgagggca tcggaacgat ggtggtgccc gacgcggcag ccaagggaga
     8101 gccgacatga gcaacgcacc cgcccactcc gcgccggccg ccggcaacgc gtcgttcgcc
     8161 gcccgctggc gcggcgcgct gatggacaac tacggcaccc cccggctggc cctcacccac
     8221 ggcgagggct cccggctgtg ggacgcggac ggcaacgcct acctggactt cgtcggcggc
     8281 atcgccgtca gctcgctcgg caccggccac ccggccgtcg tgcgggccgt ctcggagcag
     8341 atcgcgcgtc ttggccacgt gtcgaacctc tacatcgccg agcccccggt cgccctggcg
     8401 gaacgcctgc tcgggctcgc gggccggccg ggccgcgtgt tcttctccaa ctcgggcgcc
     8461 gaggcggtcg aggccgcgtt caagatcggc cggctcaccg gccgcccgca catggtggcc
     8521 accgaggggg gcttccacgg ccggaccatg ggcgccctcg cgctcaccgg gcagccgaag
     8581 aagcaggagg ggttcgggcc gctgcccggc gaggtcacgc acgtccccta cggtgacgcc
     8641 gacgccctgc gcgcggcggt caccgaacgc acggcgctgg tgatcatcga gcccgtccag
     8701 ggcgagaacg gcgtggtggt gccgcccgag ggctacctga ccgccgcgcg cgagatcacc
     8761 agggccaccg ggaccctgct cgtcctcgac gaggtgcaga ccggcatcgg ccggaccggg
     8821 cactggttcg ccgggcaggc ggagggcgtg gaacccgacc tggtcacgct cgccaagggc
     8881 ctcgggggcg gcctgccgat cggcgccacg ctggcgttcg gcgtcgccgc cgaactgctg
     8941 gcgcccggcg ggcacggctc caccttcggc ggcaacccgg tcgcgtgcgc cgccgccctg
     9001 gccgtgctcg acaccatcga gtccgagcac ctgctccagc gggtcaagga ggccggggag
     9061 cggctgcgcg acgggatctg gcgcctcggt caccccttgg tcgaccgggt caggggcgcc
     9121 gggctgctgc tcggtatcgt gctcaccgag ccccgcgccc cccaggcgca gcaggcggct
     9181 caggacgccg gacttctggt gaacgccgtc gcccccgacg tgctgcggct cgccccgccg
     9241 ctgatcatcg gcgacgcgga gatcgacgcg ttcctcacgg ccctgcccgg cgttctcgac
     9301 atcgtggaca cggcgagcgg agagcgatga gcacgggaga gagaacgtga ccgaggagtc
     9361 gggttccacg gcggcgtcgc cgcgcgccag agccgcctcg tctgcggcgg gccccgccgt
     9421 gccgcagacc cgcgcggcgc ggcaccgccg catcgtcgac atcctcaacc gccagccggt
     9481 gcggtcgcag agccagttgg cgaagctcct cgccgacgac gggctgaccg tcacccaggc
     9541 gacactcagc cgggacctcg acgaactcgg cgcggtgaag atccgcaaca ccggcggtga
     9601 gctgatctac gccgtgccga gcgagggcgg ctaccgcact ccccgggtgc cgctcgggga
     9661 gtcggccaag gaggagcgga tggccaggct cgccggcgaa ctgctgatct cggccgaggc
     9721 gtcggcgaac ctggtcgtgc tgcgcacccc gccgggcgcc gcccagttcc tggcctccgc
     9781 catcgaccag gcggaggtcc acgacatcct gggcaccatc gcgggcgacg acacgctgct
     9841 gctgatcagc cgcgacccgg tgggcggtca gtccctggcc gaccacctgc tgcggctggc
     9901 ccagaagggg aaggaggagc cggagggctg accgcccacc ggctcaccgg cccctcccgg
     9961 gcgccacctt cgcgccgtgc cctccgggcg gcccgtccgc tcagcggtcc ctgcggcagg
    10021 cgagccgggc gagcgccgcg agccgttcgc ccgcggcggg ttcgggacgg gccgcgtcaa
    10081 ggcactggag cgccagccgc agctcctcct cagccgcctg ctccgcccag gccctgccgc
    10141 ccgcctcctc gaccaggccc gcgaggcggg ccgtcagctc gggttccggc gcctgccgcc
    10201 ccggcccgcc gtcggccccg ggggcgccgc cacccggcag gtacagctcg gcgagccgcc
    10261 gggcggcggg ggtgccggaa tcgagggcgg cgaccacggg cagcgacttc ttgcggctga
    10321 ccaggtcggc accggccggt ttgccggtga ccgccgggtc gccccagatg ccgagcaggt
    10381 cgtcggtgag ctggaacgcc atcccgaggt gggtgccgaa gcggcgcatc gcctcgatgg
    10441 cctcgggcga cccgccgccc cacagcgccc cgagggcgca cgaacaggcg agcagcgccg
    10501 ccgtcttgcg ctcggtcatc gccaggcact cggccagcgt cacccgcgtg cgttcctcga
    10561 acgagatgtc ggtctgctcg ccctcgatca actgggtggt ggcctcgctg agccagcgga
    10621 tgccggtgag gctcgcgagc ccggcgggct gctcggtgag cacgcgcccc gcgtggatca
    10681 gcagcgcgtc ccccgcgagc agcgcggccg aggagccgaa caccgaccag gcggtcgccc
    10741 ggtgcctccg ggtggtgtcg ccgtcgagga tgtcgtcgtg cagcagcgag aagttgtgca
    10801 cgagttccac ggcgacggcc gggcccaccg cgtcctcggg ggcggcgccg acggcctcgg
    10861 cacagccgaa cacgagcgcg ggccgcaggg ccttgcccgc gggcgcgctg tcgggccgac
    10921 cctccgcgtc ggtccagccg aagtggtacg aggcgacccg tgcgacggga gcgggcaggc
    10981 ggtgcaccca ggtgcgcagc gccgggtcga gcaactcgcg cgcccggcgc agcgagtcga
    11041 gagctgtgtg gtgctcgtcc gctgtgtggg ggacggtggt catggcaggg cctccggttc
    11101 ctccgcttcg tgggcttgct cggtgagggc cagggctgcc tctcgcggtg cctcgacggc
    11161 gcggcccccg ggaaccgtgc ggacggcctg gctccgcacg cggacgcgcc ccccacccgc
    11221 gccccacgac gcctcggggc gcgccccggc ggggccgtcg ggccggacgc gcgcgcggcc
    11281 cggccgcggg gcggggccgg tgccgcgtgg gcgtgggccg ggcgacgcga ggctccggat
    11341 ggcggcgttc acctcctcga cgggcggggc gtaccacggg gaacgggtcg tgccgccggc
    11401 gccctggccc ggcacctgcc ccaacgtggc agcggacgtg accgttcccc gcggcggtgg
    11461 ccccgccgcc gctccgccag ggcgcggggg cgcgggccgc cgtgcggggc gccggagccg
    11521 cccggccggc gcgggcgggc cgggagccgc ggtcatcccc gcaccccctc ataccgatcg
    11581 ctgctcatgc ggccagcttg gccgggcgag gggagcgctg gaaggcgcgt tcggtaatcg
    11641 ccgtgcgccc cacggggaca acctcgcgcc ctcatgcggg gagccagccg tgccgacctg
    11701 gtgttcttct caggccaaag gctccgggct gccgcgccgg ccgtcggcta atcacccgat
    11761 cgggtgaggg gccgcacgct gccgccattc ctcgccgagc accgcccaaa cctccaggtc
    11821 atgccgcttt ccgtccattt cgaaaacgct gcgcagcgtg ccctcgtgcg tcatgcccag
    11881 gcgccgggcc acggcgatgc tccgaacgtt gtcgggactc accagccatt cgacccgcgc
    11941 cagcccccgc gtccgcacgg cccagtcgat catggccgtg gccgccccgg tcaccagccc
    12001 gcggccctcc gcaccggggg acagccaggc gccgagctcg cacgagccct gccgggcgtc
    12061 gaacaaccgg tacatcatgc cgccgaccag ttcgcccgac agccagatgc cgtacaggcg
    12121 cggcccgtcc gccgcctggg tctcggcgaa ccgccgcagg aagcgccgcg ccgaatcggc
    12181 gtccgtcacg gaccgggtcc agggcagcca cggcgccagg tggtcccgcg cgcggtcggt
    12241 gtaggccgcg aactcctcgg cctgccaggg ttcgagcgcc ccgaggcggg cctcggggcc
    12301 gaggggatga ctgagcacgg ttgtgtcctc tccggccgcg gacgcccgtc cccggggccc
    12361 ggggcgattc gcccatgcgt cccccggggg cgtcgcgcgt ccatcgcccc ccggcgtcgt
    12421 cgcgcgtcca tgctcgcccg ggcggctccc gccgcgcgac cgcttttccg cggtctctcc
    12481 gcggcgaggc cgcttcctcg ggccgctgac ctggcgaatt gacgaaccat gcggcaccct
    12541 gcatacttat tccagtcagc gtatgcatcc taaggagaca ccgtgaccca gcgcgtcgtg
    12601 ctcgcctact ccggcggcct ggacacatct gtctgcatcg gctggatcgc cgaggcgacc
    12661 ggcgccgagg tcgtcgccgt cgccgtcgac gtcggccagg gcggcgagag tctggatgtc
    12721 atccgcaagc gcgcgctcgc ctgcggtgcc gtcgaggcgg aggtcgtcga cgcgaaggac
    12781 gagttcgcgc aggagtactg cctcccggcg atcaaggcca acggcctcta catggaccgc
    12841 tacccgctcg tctccgccct ctcgcggccc gtgatcgtca agcacctcgt cgccgcggcc
    12901 cgcaagcacg gcgccgacac cgtggcgcac ggctgcaccg gcaaggggaa cgaccaggtc
    12961 aggttcgagg ccggcatctc ctccctggcc cccgacctca cgtgcatcgc gcccgtccgg
    13021 gactacgcca tgacccggga caaggccatc gcgttcgccg agagcaaggg cctgccgatc
    13081 gccaccagca agaagtcgcc gtactccatc gacgccaacg tcttcggccg cgccatcgag
    13141 accggcttcc ttgaggacat ctggaacggg ccgatcgagg acatctacga gtacacgcag
    13201 aacccggcga cccccaggga agccgacgag gtggtcatca ccttcgagcg gggcgttccc
    13261 gtggccatcg acggccgggc cgtcagcgtc ctccaggccg tgcaggagct gaacgagcgg
    13321 gccggcgcgc agggtgtggg ccgcatcgac atcgtcgagg accgcctggt gggcatcaag
    13381 tcccgcgagg tctacgaggc gcccggcgcc atcgcgctga tcaccgcgca tcaggagctg
    13441 gagaacgtca cggtcgagcg cgagctggcc cgctacaagc ggcaggtcga gcagcgctgg
    13501 tccgagctgg tctacgacgg cctgtggtac tcgccgctga agcgggcgct cgacggcttc
    13561 gtggaagagg cgaacgagca cgtcagcggc gacatccgga tgacgctgca cggcgggcgc
    13621 gccgtggtca ccgggcggcg ctcgggcgag tcgctgtacg acttcagcct ggcgacgtac
    13681 gacaccggcg acaccttcga ccagtcgcag gccaagggct tcatcgacat cttcggtctg
    13741 tccaccaaga tcgcggcgcg gcgggacctc gcccagtgag cgagaaccag cccgaggtgc
    13801 ggctgtgggg cggccggttc gcgcacggac cggccgaggc cctcgaacgg ctgagcgcct
    13861 ccgtccactt cgactggcgc ctcgcgccct acgacatcgc gggctcgcgg gcgcacgcca
    13921 gggtcctgca ccgggcgggg ctgctgaccg ccgaggagct cgatcggatg ctggccggcc
    13981 tcgaccggct cgccgccgac gtggagagcg gcgcgttcac cggcaccgtg gccgacgagg
    14041 acgtgcacac cgcgctcgaa cgcgggctga tcgaacggct cggcccggag ctcggcggca
    14101 agctgcgcgc cgggcggtcg cgcaacgacc aggtcgccac cctcttccgg atgtacctgc
    14161 gggaccacgc gcggatcatc gccggcctgc tcgccgagct ccagggcgcc ctgatcggcc
    14221 tcgccgaggc gcaccccgac gtgcccatgc ccgggcgcac ccacttccag cacgcgcagc
    14281 ccgtgctgtt ctcgcatcac gtcctggcgc acgtgcaggc cctgggcagg aacgccgagc
    14341 gcctgcggca gtgggacgcc cgcacggccg tctcgcccta cggctcgggg gcgctggccg
    14401 gttcctcgct cggcctcgac ccggaggccg tggcccgcga cctcggtttc gagggcggct
    14461 ccgcggcgaa ctccatcgac ggcacctcgt cccgcgactt cgtcgccgag ttcgcgttca
    14521 tcacggcgat ggccggcgtg gacatctccc ggatcgcgga ggaggtcatc gtgtggaaca
    14581 cgaaggagtt ctccttcgtc accctgcacg actccttctc caccggcagt tcgatcatgc
    14641 cgcagaagaa gaacccggac atcgcggagc tggccagggg caagtcgggg cgcctcatcg
    14701 gcaacctgac cggtctgctc gccacgctca aggcgctgcc gctcgcgtac aaccgggacc
    14761 tccaggagga caaggagccg gtgttcgact cctgcgacca gctggagatc ctgctcccgg
    14821 cgttcaccgg catgatcgcc accctgaagg tcaaccggga gcggatggcg gaactggcgc
    14881 cggccggctt ctcgctcgcc acggacgtcg ccgaatggct cgtcaagcgc ggcgtgccgt
    14941 tccgggtggc ccacgaggtc gcgggggagt gcgtcagggt ctgcgaggcg gagggcatcg
    15001 agctcgacgc gctgaccgac gagcagttcg cgaagatctc cccgcacctc acgcccgagg
    15061 tccgcaccgt gctgaccgtg gagggcgccc tggccgcgcg cgacgccagg ggcggcaccg
    15121 cgcccgcggc cgtggccgtg cagctgcgcg aggccaagga cgacctggcg cgccagctgg
    15181 agtgggcgcg gcggtccccg ggaccggtcg cgggctgaag ccacgggggt gccgcggcgg
    15241 ccggccggcc gccgcggcac cgcgcgctac tcgcccgggt agcgcaggcc gatgcggtcc
    15301 ctgaccgcgt ccagggtgcg catcacggcc aggctgtcgt cgagcggcac cagcggcgac
    15361 tcggtctcgc cggcccgcag gcagcgcatg acctcggccg cctggtgcgc gaacgaaccg
    15421 gcggggccgg gccccgagaa ctcctcgggc tcgcggccgt cccggtgcag cacgaaccgc
    15481 tcggggtgga agaagccgcg ggggaactcg atccggccgc cggtgcccgt cacggacgcc
    15541 gtgcgcgcgg tgtccgcgac cagcgagcag gtcaacgcgg ccaccgcgcc cgaggcgtgg
    15601 ccgagcagca tcccggtgtt ctcgtcgacc ccgtcgcgca gccgggccca cgccgcgacc
    15661 tccgacggct caccgagcag caggtgcgcg aaggacacgg ggtacacgcc caggtcgagc
    15721 agcgcgccgc cgccgagcgc ggggtcgagc aggcggtggc ccgggtcgag cggcccgccg
    15781 atgccgaagt ccgcgtggac ggtgcgtatt tcgccgatcg ccccgtcccg caccaggtcg
    15841 gccatgcgcc ggatcaccgg gttgcagttc atccacatgg cttccatcaa aaagacgccg
    15901 cgggacctgg ccaggccgac caggtccttc gcctcggccg cggtgagggt gaacggcttc
    15961 tcgcacagga ccggcttgcc cgcctcaagg cacaggcgcg tcgctgcgtg gtgcgcggag
    16021 tgcggcgtgg ccacgtacac cacgtccacg tcggggtcgg ccgcgaggtc ggcccaactg
    16081 ccgtgagagc gcgggatgtc gaaccgccgt gcgaactccg cggccggtcc cggcgcgcgt
    16141 gaggccaccg cggccacctc ggcgtccggc aggtccgcga ggtccccggc cagtttggcg
    16201 gcgatgccgc cggtcgccag gatgccccac cgcacggggc ggtccgccgc gacggccccg
    16261 cccttcccgc cgtccgccat gcccaactcc tcgttcgtgc cgcgcggtcc acgctccggc
    16321 tgcgtcagaa atcaggatca tcgtatgtga cagtgccggt cgggccgcga gagcgagatc
    16381 gccgggaccg cccccgcccc cacgtccgca ccggccaccg gctagtgtcg gctgccgcgt
    16441 cccggccctc ccggccggga caccaccgtg cgggggatga agggaagcac cgtggagaac
    16501 gagccatccg taccgctgcg gtacgccgac gtgcgcggcc tgcgcctggc gtacgccgac
    16561 ttcggtggca cgggccggcc cctgctcgcc ctgcacgggc acttcggccg cgcccggatg
    16621 ttcgcgcccc tggccgccgc gctcggctcc ggccaccggg tgatcgccct cgaacagcgc
    16681 gcgcacggcg ccagcggacg ggacggcgac gtgcggcccg acgcctacct tgaggacgcg
    16741 gcggcgttcc tgcgcgacct cggcgccggc cccgccgtcg tgctcgggca ctccgcgggc
    16801 ggggtcaccg cgttccgcct cgcggcccgt caccccgagc tggtcgccgc cctgatcgtc
    16861 gaggaccacg gggcgctcaa ccggcagccg gacgtcgcgc acccggtcct cgacatcagc
    16921 ggctggccgc ggcgcacggg ctcgctcgcc gggctgcgcc gggccgtcga ggcgcacggc
    16981 atcccggacg ccgggtactt cctggagagc gcgaccgagt acgaggacgg atggggcttc
    17041 ctgttcgacc acgatcagct gatggagtcc cagcgcctcc tcatgggcga ctggtggccc
    17101 gactggctcg cctcgacctg ccccgcgctg ctgatccacg gcacggagag cttcgtgctg
    17161 cccaccgcga tggcccacgc gatggccgaa cgccggccgc gcaccacgct gcgggagttc
    17221 cccggccgcg ggcactgggt ccacgacgag gaccccgagg gcttcgcccg cgccgtcgcg
    17281 gacttcctcg ccaccctctg agctcgttct ttgtcttccg gccccgtcga agggccggaa
    17341 gatggtgtcc agctcagaag gtcaccgtga tcttgccttc caagccgcct tgggcgaagc
    17401 gttcgtgggc ggttcggatc tcgtggaggc cgtaggcgga gtgcacgcgc agccgtagcg
    17461 agccgcggtc gacaagcttg gtcagccggc ccagtcctat gccgtcctcg cgtacctggt
    17521 tgaccgtggt gcggacgtct cgcgatgaca ggtcggggac ggggccggcc tgggtggcga
    17581 tggaggcgta ccggccgccg tcggccaccg cttcggtcac gaaagccccg aaggtgtcga
    17641 agaccgcgtc gtagctgcgg tcttggagag cgttccggtc cgtggtggcg agttcggcgc
    17701 cgtgtgtgcg ggcgaagcgg gtgtgctcgt cgcgggacac cagagcgtcc acctggagcc
    17761 ctcgcgcgtg ggcgatttgc agcgccagtc ctccgacggc gcctgcggct ccggctatga
    17821 gcagccgttc accggcggac agggagagcc agtccagggt ctgcaaggcg gtcagtccgg
    17881 gcagtggcaa ggtggccgcc tccaccagac tgacggcctg gggtgcgggt gcgagcgcat
    17941 gtgccggaag caccaccagg tcggcccagg tcccccggcc ggtgctgagc tggtgcgaca
    18001 tcgcgatgac gcgctccccg gggcgcaggt cgctggagcc gccgtcgacc acgatgcctg
    18061 cgagatccca gccgagcgtc atcggcagcg gcggcgtccc cttgccgatg gcgccctccc
    18121 gcgtcttgtc gtcgacgggg ttgatgctgg tcgcgacggt acggatcagc acgtcaccgg
    18181 cgccttgttc aggctggggg gcatcgacga cgccgaggac ttcaggtccg ccgaaacgag
    18241 cgatccgtat ggcgcgcatg gggagaaacc tttcgtggtg ccgctgatca cgagcggtgc
    18301 aacgccctcg aagatcacgg gattccctcc tccgccctcg ttccacaggc cgattcatgg
    18361 cctgctggaa ccacgcggag ccagccccac cggtgtggct gtggtcctcc gagaccggcg
    18421 ccacctcgaa agacgtcgac cgctgccggc aggcgttcct gcgacgcttc gacccggagc
    18481 acacattccg gttcgtgcag cggaccccgg gctgaccacc ccgaagatcc gtgtccccga
    18541 ggccgcggac cgctggacct gtatcctcgt cgccgcccac acccagctcc ggctcgccag
    18601 gcacctcgtc gcagacctcc gccacccctg ggagaagccg accggaccgg agcagctgac
    18661 cccagcccgt gtccgccgga aagaacaagc tgagccgacc gcggcagccc gggcggatac
    18721 ggtgaacgca cgcacccgag gccgccgcga gggcggcaca cgttccgaag gtcaccgcat
    18781 ggcgttctcc cgcttcaccc cggccgcgac cggcgccgcc cgcatcgggc tcggcctcgc
    18841 cgccgtcggc cgccccgggt acatcaacct cgggcgggcc cgcgacctgc ccgcgccgcg
    18901 cacgccggag gcgctgcgcg cccgcaccca ccagctgctc gacgcggcgc acgcggccgg
    18961 cgtccgctac ctcgacacgg cgcgttccta cggcagggcc gaggagttcc tcgccgactg
    19021 gctcaccggg cggcccgagg cggccgacgt cgtggtcggc agcaagtggg gctacaccta
    19081 cacggcggac tggcgtgccg acgcggacgt ccacgaggtc aaggaccacg gggccgccat
    19141 gttcgaccgg caatgggccg agagccgggc gttgctcggc ggccggctcg acctgtacca
    19201 gatccactcg gccacccagg acagcggggt gctggccgac ccggccgtgc tcgaccggct
    19261 ggcgcgcctg gccgacaccg gcgtcgacgt gggcctgtcc accagcggcc cgcgccaggc
    19321 ggagacgatc cgggcggcgc tggaggtcga acggggcggg cgacccctgt tccggacggt
    19381 gcaggccacg tacaacgtgc tggagcagtc cgccgccccc gcgctcgcgg aggcgcacgc
    19441 ggcgggccgc accgtcatcg tcaaggaggc gctggccaac ggccgcctcg ccgggcccga
    19501 ggcgccgggc gagctgcggg aggtcgcgga cgcgaccggc accgggcccg acgccgtggc
    19561 cctcgccgcc gtgctggccc agccgtggac cgggatcgtc ctgtcggggg cggccaccga
    19621 ggggcagctc gcggacaacc tcgccgccgc ccggctgcgc ctggacgccg cccacctgga
    19681 ggcgttcacc cggctggccg aaccgtcgga cgcctactgg cgcgcccgtt ccgcgctgcc
    19741 ctggacctga cgcggggcgc gggcgtgggg cgcgccctca ggcggccttc gccttggtgg
    19801 cgtacatgtc cacgtactcc tgcccggaga ggcgcatcac ctcggtcatc acctcgtcgg
    19861 tgacggcacg cagcacgtag cggtcccggt ccatgccctc gtaccgcgag aagtcgagcg
    19921 gctggccgaa ccgcaccgtg atccggcgcc cccggccgac ccgcggcagg ccgcgcccgc
    19981 cgggctggac ccggtcggtg ccgatcatcg cgaacggcac caccggcgcg cccgtcatca
    20041 gcgtgagccg cgcgattccg gtgcgccccc ggtacagacg tccgtcgggt gaccgggtgc
    20101 cctccgggta gatgccgaag accttgccct cctccaggac gcgccgcccg gtcatgaggg
    20161 cggccacccc gccgtgcccg ccgtcccggt cgaccgggat catgccgacg gccgtgaaga
    20221 accacgccat caggcgaccc cgcagggaac gacccttgac gtactcgtcc ttgccgatga
    20281 agaagacctg ccgctccatg accagcggca gaatgatcga atcgatgaac gtgaggtggt
    20341 tcccggccag gatcaccggc ccgtcggcgg gaatctgccg gattccctcg acccggggcc
    20401 ggaagaaaag cttcagcaac gggccgagca gcaccttcag cagcacgaaa cgggacaact
    20461 tcccctccgg tcggtcatgg gcatgcgtgt ttcagcatgc ctagggacga tacccgcgcc
    20521 ggggcacacc gcgcgcaccg ggtgctcgcc cccgatactc gggtttgacg cgcattcccc
    20581 ggccgttccc ccgcatgtac tcgtggggac agcgccgctt ccctacgatc gggcgcgatc
    20641 acgggccgcc ggagcgcggc ccgacgacgg acgagcccta cggagtgacg atggcagctc
    20701 accagacggc aggcgcggac gcggggcacc cggggcggcg ggccctgctc ggcatgacgg
    20761 cgggcgcggc cggcgccgcc gccctgctcg gcaccgcgac ccccgcggtc gcgggctcgc
    20821 ggcccgcggc gcgcggcatc gcccgcgaac tgcccgttcc cgcggtcatc gcccaccgcg
    20881 gcgcctccgg ctaccggccg gaacacacca ttggcgccta ccagctcggg ctcgacatgg
    20941 gcgccgacgt catcgagcag gacctggtgc ccaccaagga cggccacctg gtctgccggc
    21001 acgagaacga catctccggc accaccgacg tcgcggacca ccccgagttc gccgaccgcc
    21061 gcaccaccaa gaccatcgac ggg
//
