LOCUS       NZ_CP021121            25008 bp    DNA     linear   CON 31-JUL-2024
DEFINITION  Streptomyces marincola strain SCSIO 03032 chromosome, complete
            genome.
ACCESSION   NZ_CP021121
VERSION     NZ_CP021121.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces marincola
  ORGANISM  Streptomyces marincola
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6287975)
  AUTHORS   Ma,L., Zhu,Y., Zhang,W., Zhang,G., Tian,X., Zhang,S. and Zhang,C.
  TITLE     Complete genome sequence of Streptomyces sp. SCSIO 03032 revealed
            the diverse biosynthetic pathways for its bioactive secondary
            metabolites
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6287975)
  AUTHORS   Ma,L., Zhu,Y., Zhang,W., Zhang,G., Tian,X., Zhang,S. and Zhang,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2017) Key Laboratory of Tropical Marine
            Bio-resources and Ecology, South China Sea Institute of Oceanology,
            164 West Xingang Rd., Guangzhou, Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method :: Hierarchical Genome Assembly Process v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 165.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002128305.1-RS_2024_07_31
            Annotation Date                   :: 07/31/2024 06:55:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,513
            CDSs (total)                      :: 5,438
            Genes (coding)                    :: 5,343
            CDSs (with protein)               :: 5,343
            Genes (RNA)                       :: 75
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 95
            CDSs (without protein)            :: 95
            Pseudo Genes (ambiguous residues) :: 0 of 95
            Pseudo Genes (frameshifted)       :: 19 of 95
            Pseudo Genes (incomplete)         :: 88 of 95
            Pseudo Genes (internal stop)      :: 2 of 95
            Pseudo Genes (multiple problems)  :: 13 of 95
            CRISPR Arrays                     :: 12
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:29:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4271924
            Orig. end                         :: 4296932
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP021121.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Key Laboratory of Tropical
            Marine Bio-resources and Ecology.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25008
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="19"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25008
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25008
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15008](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15008)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            556..735
                     /locus_tag="CAG99_RS18955"
                     /old_locus_tag="CAG99_18940"
     CDS             556..735
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018511441.1"
                     /locus_tag="CAG99_RS18955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_18940"
                     /product="hypothetical protein"
                     /protein_id="WP_086162331.1"
                     /transl_table=11
                     /translation="MDISALIPAPGPTTAREMPLTSEPPLGDLTPLTAEQPLAVEPPLT
                     SEPNGHGGAESPGA"
     gene            847..2895
                     /gene="malQ"
                     /locus_tag="CAG99_RS18960"
                     /old_locus_tag="CAG99_18945"
     CDS             847..2895
                     /EC_number="2.4.1.25"
                     /GO_function="GO:0004134 - 4-alpha-glucanotransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0005980 - glycogen catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="malQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016826243.1"
                     /locus_tag="CAG99_RS18960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_18945"
                     /product="4-alpha-glucanotransferase"
                     /protein_id="WP_086160488.1"
                     /transl_table=11
                     /translation="MDTERLSRLAAAHGVATSYAPSPGRRVDVPRDTVVAVLAALGVDA
                     ERPRPRQDRLLPPTVVRRPGQAPPEVPAGTVLRVVTEDGTDRDWAGGPPLAPGHHALYA
                     RTPDGRAERAALIVPPPRLPGPPGRTLGLLVQLYSVLSARSWGMGDLVDLADLASWAGH
                     TLGAGFIQLNPLHAAVPGAPGTPTDPSPYRPGTRRFADPVHLRIEDIPEYAYLGAEARR
                     EADALVARAAELRQAVLREDRPIDRDAVWALKLRALEIVRQVPLGPGRHAAYCAFLASQ
                     GQALEDHATWCALAELHGPDWRAWPAGLRDPRSPATARARGDHLARIDFHSWLAWLTDT
                     QLARAQRVAQAAGMPIGLVHDLALGVHPHGSDAWAQQDVLATGMSAGAPPDAFNERGQD
                     WGLPPWRPDALAERGYAPYRDLLDGLLRHAGALRVDHVMGQFRLWWIPEGAPPDRGTYV
                     SYDADAMLGVLSLAAHRAGAVLVGEDLGTVEPGVREDLAERGVVGTSVLWFERHWERRG
                     KPPLRPAEWRAGCLATATTHDLPSTAARFDGDHVRLRQRLGLLTEEQAADALRAALGES
                     AEWLEELARLGLLPRAAGEEQRITAAYRYLARTPARMVGIWLPDTVGDRRPQNLPGTWQ
                     EYPNWRLPVADGAGRPVTLEELAGSARVARLVRAVREEIARHPTAGA"
     gene            2940..3164
                     /locus_tag="CAG99_RS18965"
                     /old_locus_tag="CAG99_18950"
     CDS             2940..3164
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016468999.1"
                     /locus_tag="CAG99_RS18965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_18950"
                     /product="hypothetical protein"
                     /protein_id="WP_086162332.1"
                     /transl_table=11
                     /translation="MKNSKRGARAATVSVGALLLTLMASPAAQALTRDDGDDPGTGLSV
                     AETIGYFVVTPIVLFAVITGLVILSDRKR"
     gene            complement(3231..3689)
                     /locus_tag="CAG99_RS18970"
                     /old_locus_tag="CAG99_18955"
     CDS             complement(3231..3689)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446439.1"
                     /locus_tag="CAG99_RS18970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_18955"
                     /product="hypothetical protein"
                     /protein_id="WP_086160489.1"
                     /transl_table=11
                     /translation="MKGVAGLLNALHRGETALAAHLLAVADRHRAEHEVHHVATDLARW
                     SRRHGELIADAAPRYGGAIGPGGGQEAAGRGAEDSDDVPPLLLDLRALHLAASGNAVYW
                     EMLGQAARATRDERLLDLADTCLPHAMRQVGWARIMLTTQSPQLIVAG"
     gene            complement(3686..6055)
                     /locus_tag="CAG99_RS18975"
                     /old_locus_tag="CAG99_18960"
     CDS             complement(3686..6055)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1134: flavodoxin"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010038185.1"
                     /locus_tag="CAG99_RS18975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_18960"
                     /product="molybdopterin oxidoreductase family protein"
                     /protein_id="WP_086160490.1"
                     /transl_table=11
                     /translation="MAARERRIVDPWGERTPYGRGEPWPVRVDTHLAPGVARETVERWV
                     PAASLLHSNGDAMDIAVRKGRIVGVRGRAHDRVNRGRLGPKDLFGWQANASRDRLTHPL
                     VRRGGRLVEADWDTAMGLVAERSRDLLAEHGPSSLGFYTSGQLFLEETYTLAVIARAGL
                     GTNHIDGNTRLCTATAAEALKETFGCDGQPGSYADVDHADTIALFGHNAAETQPVLWMR
                     VLDRLDGPDPPRLLCVDPRATPVARRADVHLAPRPGTNLALMNALLHEVIRAGHVDERR
                     VAEHAVGFDELRAAVAECTPAWAAEICDVPAEDIAAAARLLGGARRLLSTVLQGFYQSH
                     QATAASVQVNNLNLLLGMVGRPGAGILQMNGQPTAQNTRECGANGDLPGFRNWQNPDHV
                     ADLARVWNVDPLTIPHWAPPTPALQIFRYAEQGSLHMLWISGTNPAVSLPELARIRSVL
                     SQERLFVVVQDLFLTETAQLADVVLPAATWGEKTGTFTNADRTVHLSEQAVAPPGEARS
                     DLDILLDYARRMDFRDRSGGPLVSWHDPPSAFAAWQRCSAGRPCDYTGLSYDLLRARGG
                     IQWPCTAQVPEGTERLLTDGVPWAAAEVCETYGRDLITGASVDPSTYRTLNPEGKAVLK
                     AAEYLPPHEEPSEDFPFRLTTGRTIYHFHTRTKTGRVPELNAAAPDMWVELCAADAAGL
                     GLAAGDLVEVTTPRGSARGVLRIADVRRGTVFTPFHYGYWDTPAGHRPPEGEPGRAANE
                     TTVTDWDPVSKQPLYKTAAARVVLVARGAGTEGGTR"
     gene            6381..7205
                     /locus_tag="CAG99_RS18980"
                     /old_locus_tag="CAG99_18965"
     CDS             6381..7205
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019433074.1"
                     /locus_tag="CAG99_RS18980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_18965"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_176582953.1"
                     /transl_table=11
                     /translation="MSAVSGVSPEEPVDLRTDQPHSARMYDYLLGGKDHYAADGEAAEK
                     ALLSFPLLRTAARENRKFLGRAVSYLVREAGIRQFLDLGSGLPTAENVHQVAQREAQDA
                     RVVYVDNDPIVLVYGGALLARDANTAVIQGDIRDPRSVLDHPETRRLIDFDQPVGILAV
                     AVLHFVGDDEDPAGIVRTLCDAVPAGSHVILSHATADIAPEAALGVQTAYRSQGVPLTL
                     RDKGQFTAFFDGLDIVEPGIQVVSDWRATVPEAERPAHADVSWYGGIGRVTG"
     gene            7301..8440
                     /locus_tag="CAG99_RS18985"
                     /old_locus_tag="CAG99_18970"
     CDS             7301..8440
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CAG99_RS18985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CAG99_18970"
                     /product="hypothetical protein"
                     /protein_id="WP_086160492.1"
                     /transl_table=11
                     /translation="MTHRRTFLVGVLVAALAAASAGCSGDGNAPSGSGSPSPSPAPPPS
                     AGGYAYVKVEFGQSWTDTQSQLVVMDGGEEIGRSDPLFLAGRPLFTSDGRYAFVLPSLL
                     DEIVVISADTGETRSVPCEGCEARQTECHCQVVAPIGGSRIAWLDGGNRLVVTDLADAA
                     PTPRPTDVTLPEQDGFLDERVVPNLIAGTEGAALAAYPHGSLAGDDLMPAFLVTPDDQP
                     RRLDPRRPDAIEEAAFSPDGTRVALTGNQEYTCTTVTVVDVASGRGGTAPVLAAPGTEC
                     EGVDAYIDGMWWDPDGGLHVTYETDEGDTWSEESTAPEEGQRRLHEGRWVDSDVGRATE
                     RRQLSAGTATIRGDGTLLVESGGRQTEIDTDVRYLIAAP"
     gene            complement(8807..9931)
                     /locus_tag="CAG99_RS18990"
                     /old_locus_tag="CAG99_18975"
     CDS             complement(8807..9931)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612040.1"
                     /locus_tag="CAG99_RS18990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_18975"
                     /product="hypothetical protein"
                     /protein_id="WP_086160493.1"
                     /transl_table=11
                     /translation="MDPHGFLARRFPLVSRTRPACLPLARRVHALVDLAGTATAGADPV
                     LASAVYNQAALLASDLELPELARQWCHQHAAAYLHAAPLPGKIAVRALEPVVNLARLDI
                     RAGNTDDGRHRLLTLYHAVSDATYTQFQSTRIPADLTISDTDRHEVRAWLWRVILADGT
                     RALTSAGRWEDALHHLKQHNGIGQRMLDGRQVAVLAALHRDPAHAADLVNQTAPGEAWE
                     EAVTSCLTVMCRRRLHRPVEPLLSELVEAYLHHQPDPGTIVFDTRLGLTLLNLIEPPDD
                     VAACRIAQKLHHRAINTSDGYAARECLADQRFTDLVKPADAQIVRDLVHSCALARRHLP
                     QPEFDQLARALQLSNKVIRKNLACPHDRPRGCSR"
     misc_feature    complement(9911..9913)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10001..10843)
                     /locus_tag="CAG99_RS18995"
                     /old_locus_tag="CAG99_18980"
     CDS             complement(10001..10843)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003953652.1"
                     /locus_tag="CAG99_RS18995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_18980"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_086160494.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.3e-32, bitscore:
                     110.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQPTWRQVNVEFPHWEHAETTAVKHIAPFLRAAEAVGTITAWFI
                     IRKRPCWRVRYTPVAGAPNALDQHLDELVAAGHATVWAEIIYEPEVHAFGGAQSMDSAH
                     RFFHRDSRALLEFLGSGAVRHRRETSLMLCSLMMRAAGLDWYEQGDVWARVAAHRAPPP
                     DSGQHHGDRLHTAVHRLLSVDSQYAVQPGGPLAEHTDWGAAYTDAGEDLAHLNGTGQLR
                     RGLRDVLAHHVIFAWNRLGLSYTAQATLTAAAKTMTFGSDPSAEKNPASTAGARSRDA"
     gene            complement(10864..12108)
                     /locus_tag="CAG99_RS19000"
                     /old_locus_tag="CAG99_18985"
     CDS             complement(10864..12108)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138950.1"
                     /locus_tag="CAG99_RS19000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_18985"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_086160495.1"
                     /sec_met_domain="LANC_like (E-value: 3.7e-40, bitscore:
                     136.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSATAPPSAARSTVDKLADALADPTTAWPNGRPAGGRAWPQSLAG
                     GASGIALLHIERARSGHGTWSTAHTWLTAAVHGEVSAADNANLYFGAPALAFVTHRAAS
                     ASGRYLRLLERLDSATVSVTRARLTAAHLRIDRAARPPMEEFDLIQGLSGLAAYHLSRH
                     RHHEITSDTLAYLVRLTEPLSDPAGLPPWWMNVAPTGASHPDFPDGHGNFGLAHGIGAA
                     LAVLSQALLCGLAMPGLADAVERICSWTDRWRQGNDACPWWPGLISAQQAADHHVHAEL
                     RPRPSWCYGASGTARAQQLAGLALRDPTRVQLAENAILDALRDPNQRAMLPEIGLCHGM
                     AGLLQAAWRMATETDNAEIAAELPPLAGRLITELEKKKHDPELLDGTAGAALALHTLAT
                     NDAPAPHWDTFLALA"
     gene            complement(12105..15008)
                     /locus_tag="CAG99_RS19005"
                     /old_locus_tag="CAG99_18990"
     CDS             complement(12105..15008)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009322738.1"
                     /locus_tag="CAG99_RS19005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_18990"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_086160496.1"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 8.8e-20,
                     bitscore: 69.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_N (E-value: 5.8e-111,
                     bitscore: 369.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.1e-22, bitscore:
                     77.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYRYADAALIRGAAIRGDQRIDWPDLVSGAANAMSWRVWLQQMWA
                     DAEFAAAVTAASPDLANQVERVCAGRPLPEVDVRRTVLAVLRYLLRARTRATPFGLFAG
                     IATARIGTRTDVRFGHAHCSSARADAERSTVLVDRFEQHPALRPHLMLLASNLAVEHDG
                     HVVLEHRPSGRRNTGPEHARIRVTGPVRAILHGAREPIRWTDLSAKLAVDFPDAPPGAV
                     DKLLAGLVRQRVLLTSLRPTMTTADPLSGLDDHAHHLSPGERAELSDVDRPVVDLRLDW
                     HLTLPETVAHEAAKAAKALTRLAPRAALTGWAEWHARFLDRYGPRATVPVLEVVDVLGY
                     PPGYRGSTAAPALSPLPDRDGRLIKLAHAAAVRGRTEIVLDDDALEALATTDQSHPVQP
                     STEVTVRIEARDATALQRGDFVLHVVGVARSAGATTGRFLDLLPDEERRRMTMVYAELP
                     GVHRDAVVAQLSASPLSVRAQNVARAPQATDLVISLGEYRGSSTGSIPLADLAVTADAE
                     QLHLVSLSRRRPVHTLLLNAVDLGLHSHPLTRFLAEAPVALTVPCTGFLWGAAASHLPF
                     LPALRYGRTVLSPARWLLTNGELPGTSAPWQEWDEALTRWSGDARLPERVYLTDADQRI
                     ALDLAESSHRALLRAHLDRHGTATLHPAPGPGDAGWADDRSHEVVIPMFTEQNRAPVRS
                     TPHFSPRKHGHLPGSGDRLYLQLHGRQDRQDAVLTRHVPALLSELGDVRCWFVRYRDPD
                     DHLRIRLTCAPGTLGKTFESIGEWSEHLRDRGLITRSSVETYHPETARFGGPEAIDAAE
                     RYFAADSCAALAQLTAAGAKGAPDARAVTAASMVEIAVGLLGDRATAMRWLIEHTRSDT
                     AAPSRAVYRQAIDLVHTYPAGVDERIVAASSARRAALAGYAHALTAAHTDPGDLLPDLL
                     HLHHVRVQGPGLPQERAHLHLARAAALSWTARARRTA"
     aSDomain        complement(14283..14549)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CAG99_RS19005_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="4.50E-22"
                     /identifier="RREFam001.1"
                     /label="CAG99_RS19005"
                     /locus_tag="CAG99_RS19005"
                     /protein_end="242"
                     /protein_start="153"
                     /score="69.5"
                     /tool="antismash"
                     /translation="ASNLAVEHDGHVVLEHRPSGRRNTGPEHARIRVTGPVRAILHGAR
                     EPIRWTDLSAKLAVDFPDAPPGAVDKLLAGLVRQRVLLTSLRPT"
     gene            complement(15093..15284)
                     /locus_tag="CAG99_RS19010"
                     /old_locus_tag="CAG99_18995"
     CDS             complement(15093..15284)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009322874.1"
                     /locus_tag="CAG99_RS19010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_18995"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_086160497.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 3.1e-16, bitscore:
                     57.4, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVPMESLATSAHSAGVLMSSGEPADWELDVSIVEGGPAADQLIR
                     LTGDGCNSTCATACVSCP"
     CDS_motif       complement(15162..15284)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MEVPMESLATSAHSAGVLMSSGEPADWELDVSIVEGGPAAD"
                     /locus_tag="CAG99_RS19010_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15093..15161)
                     /prepeptide="core"
                     /locus_tag="CAG99_RS19010_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-13.00"
                     /molecular_weight="2123.4"
                     /monoisotopic_mass="2122.0"
                     /core_sequence="QLIRLTGDGCNSTCATACVSCP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEVPMESLATSAHSAGVLMSSGEPADWELDVSIVEGGPAAD
                     "
                     /leader_location="[15161:15284](-)"
                     /alternative_weights="2141.5"
     gene            complement(15347..16552)
                     /gene="fxlM"
                     /locus_tag="CAG99_RS19015"
                     /old_locus_tag="CAG99_19000"
     CDS             complement(15347..16552)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138947.1"
                     /locus_tag="CAG99_RS19015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_19000"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_086160498.1"
                     /sec_met_domain="PCMT (E-value: 2.3e-38, bitscore: 130.4,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAIDDSTVRSPDALRADMVRALRAEDGVRTEPVAAAFSTVPRHR
                     FAPDASPEVAYSLHSIVPVKKDEHGSDVSVMSTAHLQAVMLEQADIEPGMHVLEIGSGG
                     VNAAYLQELVGTAGEVTTVDIDRDVLARARRCLDDVGYTQVKTVLADGEHGVPEGAPYH
                     RIIVTAAAWDIPPSWISGLTEKGRIVVPLTVHGTTRSIAFDRDGNRLISHSYRLANFVP
                     MQGEGAADERKVMLREGVVLRTDDARVPLAPQALNAALDGSRLERWSGAAYDLPDELDL
                     FLTLNLSSPARLHAAPGIVDSGLVEASALRGVPALVGRDSIAYRTRRENAGTGGFESGV
                     IAHGPQAEALADQYTDLLRRWAQNHRRRGAATLRYLPGPAPTPLPEAAVPRRHGIVTAT
                     WA"
     misc_feature    16628..16645
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: medium, score: 26.51"
                     /tool="antismash"
     misc_feature    16746..16759
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.67"
                     /tool="antismash"
     gene            complement(16867..17094)
                     /locus_tag="CAG99_RS19020"
                     /old_locus_tag="CAG99_19005"
     CDS             complement(16867..17094)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CAG99_RS19020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CAG99_19005"
                     /product="hypothetical protein"
                     /protein_id="WP_086160499.1"
                     /transl_table=11
                     /translation="MRGVLVAVEIDARTVAVGDQVMIGGQSFVVRDLTALGAGRKRLEF
                     HSGETFVMNRTTILWAARRHDPRIPRGRPW"
     gene            complement(17430..17729)
                     /locus_tag="CAG99_RS19025"
                     /old_locus_tag="CAG99_19010"
     CDS             complement(17430..17729)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CAG99_RS19025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CAG99_19010"
                     /product="hypothetical protein"
                     /protein_id="WP_159029893.1"
                     /transl_table=11
                     /translation="MRAPSLVGTRVVGVLRDRSGPVVEDRFARTMTWLVPAGATAGWDA
                     GLLGVQVLGRGLALLVPPADALDPRWSVVWWAIPPNAVCLTDSGVLLDALRGAR"
     misc_feature    complement(17821..17837)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.31"
                     /tool="antismash"
     gene            complement(17905..19188)
                     /locus_tag="CAG99_RS19030"
                     /old_locus_tag="CAG99_19015"
     CDS             complement(17905..19188)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.4"
                     /locus_tag="CAG99_RS19030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_19015"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_086160501.1"
                     /transl_table=11
                     /translation="MSPDGGANQDVERLGSLIRRLREDAGMSQGELAAAAERHQPRSHG
                     GLDVGQISRWEREVRLIGPYWLPAMAEALGVPEERLRRARAASKAARRRVRGPQPTGVD
                     AVLRDLLPPDEPLAAVETRAGARVGMRDADRILRRAHALRLADDLVAGGDLVDAAMQEL
                     NAARELFNASSHSEPVGRRLLVGIAELAQLAGWVASDVTNGPDVARVFRLGAAAAREAE
                     DRPLLGQLLGSWAYFETNRGHHSLGRDLALRLGTESGPEAPPRARSLVADRTAWCSVRA
                     GDVQTALRAVGESAEALAEHEPGDDADRHWLYWVGDDERRIMEARVYTVARRPLRAVPL
                     LREVLADYPADHTRELALYYSWLATSLLDGGEPEEAAAAAGRTLELSASVPSARAAARS
                     KAVLTALRPHAAVPEVAEVLAEWGPPVA"
     misc_feature    19296..19311
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.15"
                     /tool="antismash"
     gene            19540..19731
                     /locus_tag="CAG99_RS19035"
                     /old_locus_tag="CAG99_19020"
     CDS             19540..19731
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019064527.1"
                     /locus_tag="CAG99_RS19035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_19020"
                     /product="hypothetical protein"
                     /protein_id="WP_086162333.1"
                     /transl_table=11
                     /translation="MLVTECPDACDKKDCPTLYATDRGTLLVRGDLTDEHKLELPAHEG
                     VVEIQLSLIKKAIARGHL"
     gene            19718..20251
                     /locus_tag="CAG99_RS28965"
     CDS             19718..20251
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016434767.1"
                     /locus_tag="CAG99_RS28965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6879 family protein"
                     /protein_id="WP_255308212.1"
                     /transl_table=11
                     /translation="MATSDTRKPPTLGELFDSFRREAFRLETLDDYSGSGSTDAYQAFL
                     AGEKKPDSYNSDWISEVSGHVGEGKRIYRVHVLSRPLTPYLRFELGWGYRTNATAGEDF
                     FILDVTDSPNPVAGIGDFWMFDEKFSVPMEYRDGTMTGYAVLTGVRAQEFVGYRDAALR
                     HAVPFQDWWEQHAE"
     gene            20248..21078
                     /locus_tag="CAG99_RS19040"
                     /old_locus_tag="CAG99_19025"
     CDS             20248..21078
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003957814.1"
                     /locus_tag="CAG99_RS19040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_19025"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_255308448.1"
                     /transl_table=11
                     /translation="MNKGELGAALRALREISGQPGKAVARSSVMSVSKLSKIETGKLTP
                     SIADVERILTAIGVSEEVKAEYLELAREELTEVTAWRIIQRMGLHKAQEQTRALEAQMT
                     VLRLFQSALIPGLLQTPEYVRAVLGRHGLTEEVFNRTTQTRLARQAILYEGDKELHFVI
                     TETVLRWRIVSPARMVEQLDRLISLSRLTNVHISVIPFEAAQDDIASHAFVIRDDRTVT
                     VETVHAEIVVTDPRDVALYVAKFYRFERNSLQGDKMRAMLEKLRDELLREQGSG"
     gene            complement(21234..23798)
                     /gene="pepN"
                     /locus_tag="CAG99_RS19045"
                     /old_locus_tag="CAG99_19030"
     CDS             complement(21234..23798)
                     /EC_number="3.4.11.2"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008237 - metallopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene="pepN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005317529.1"
                     /locus_tag="CAG99_RS19045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_19030"
                     /product="aminopeptidase N"
                     /protein_id="WP_086160503.1"
                     /transl_table=11
                     /translation="MPGTNLTRQEAQERARLLGVDSYDIALDLSGAREGGTFRSETTVR
                     FTARAAEPVFVDLIAPRVREVVLNGAALDPAEVFADSRIALADVAEGANELRVVADCAY
                     TNTGEGLHRFVDPVDEQVYLYTQFEVPDARRVFACFEQPDLKATFRFTVTAPEGWTVVS
                     NSPTPEPENGVWRFEPTPRISTYITALIAGPYHAVHSSWEGADRSVPLGLYCRPSLAEH
                     LDADALFEVTRQGFDWFQEKFDHPYPFAKYDQLFVPEFNAGAMENAGAVTIRDQYVFRS
                     KVTDAAYEMRAETVLHELAHMWFGDLVTMEWWNDLWLNESFATYTSIACQAHAPGSRWP
                     HAWTSFANQMKTWAYRQDQLPSTHPIMAEIRDLDDVLVNFDGITYAKGASVLKQLVAYV
                     GQDAFFRGVQAYFKRHAWGNTRLTDLLTALEETSGRDLKSWSRAWLETAGINVLRPELA
                     VDADGTITAFAVRQEAPALPAGASGEPVLRPHRIAIGLYALREGRLERTDRIELDVDGE
                     LTEVPELVGRARPDVLLLNDDDLSYAKVRLDSDSMAAVTAHLGDFTESLPRALCWASAW
                     DMTRDGEMAARDYLALVLSGIGKETDIGVVQTLHRQVKLALDLYAAPEWRETGLATWSD
                     AALERLREAAPGSDHQLAWARAFIATARTGEQLDLLAALLDGSESIEGLAVDTDLRWAL
                     VQRLAATGRADTALIDAELARDATSAGERHAAAARAARPLPEAKAEAWASVVEGDTLPN
                     ALQEAVISGFVQTDQRDLLAPYTEKYFAALKDVWAGRSHEMAQQIAVGLYPAIQVSRQT
                     LEVTDAWLATAEPSAALRRLVTESRAGIERALTAQAADAATD"
ORIGIN
        1 gcgtgccgta ccgcaccgcg gtgccgctca cccgcagggc gctgttcgcg cgcgacggcg
       61 ggcgctgcgc ctactgcggc ggtgtcgcga ccagcgtgga ccacgtcgtg ccgcgcagca
      121 ggggcgggca gcacgcgtgg gagaacgtcg tcgccgcgtg ccgcagctgc aaccacatca
      181 aggccgaccg gcacgtcgcc gagctgggct ggcggctgcg gcacccgccg ggaccgccgt
      241 ccgggctggc ctggcgcatc atcggcaccg ggcaccgcga cccgcggtgg atgccctacc
      301 tgcgccccta cggagccgac gacgcgctgg cgcggatcga gggcagaccc gcctgaccgg
      361 gaggcatgga ttccgcaatt cctggtactc gcggggacgc ggacgcgaga ttttccgtcg
      421 aggagggcgt gaggtgggtc gctttcccgt cgcggggacg gatgtcgtgg cgttcactgg
      481 gtagagcagt accgagccca ccgccgtcag tgaacggagt gacccgtggc cccagcagcc
      541 cggatcgacg acaaactgga catctccgcg ctcatccccg ccccaggacc gaccacggcc
      601 cgcgagatgc ccctgaccag tgagccgccg ctcggcgacc tgacgcccct caccgcggag
      661 cagccgctcg ccgtggaacc gcccctgacc tccgagccca acggccacgg gggcgcggag
      721 tcccccgggg cctgaggcgc ggcggacgtt ccggaagcac cacgagcacc acgagcacgg
      781 agagcacgac cagcaccaag ccgaagacac aaggacaaga agacacgaaa gatacgtcgg
      841 agcctgatgg acacggagag gctgtcgcgc ctcgccgcgg cgcacggcgt cgcgacctcg
      901 tacgcgccgt cccccggccg ccgcgtcgac gttccccggg acaccgtcgt ggccgtcctg
      961 gccgcgctcg gcgtggacgc ggaacggccc cggccgcgcc aggaccggct gctgccgccc
     1021 accgtcgtgc ggcgcccggg ccaggcgccg cccgaggtcc cggcgggcac cgtcctgcgt
     1081 gtggtcaccg aggacggcac cgaccgcgac tgggccggcg gcccgcccct ggcgccggga
     1141 caccacgcgc tgtacgcgcg cacgcccgac ggccgcgcgg aacgggccgc gctgatcgtt
     1201 cccccgccgc gcctgcccgg gccgcccggc cgcacgctcg gcctgctcgt ccagctgtac
     1261 tcggtgctct ccgcccgctc ctggggcatg ggcgacctgg tggacctggc cgacctcgcc
     1321 agctgggccg ggcacacgct gggcgccggc ttcatccagc tcaacccgct gcacgccgcc
     1381 gttcccggcg cccccggcac gcccaccgac ccctcgccct accggccggg aacgcgccgc
     1441 ttcgcggacc cggtgcacct gcggatcgag gacatccccg agtacgccta cctcggcgcc
     1501 gaggccaggc gcgaggccga cgccctcgtc gcgcgggccg ccgagctgcg gcaggccgtg
     1561 ctgcgcgagg accggcccat cgaccgggac gccgtctggg cgctgaagct cagggccctg
     1621 gagatcgtcc gccaggtgcc gctcggcccc gggcggcacg ccgcctactg cgcgttcctc
     1681 gcgagccagg gccaggcgct cgaagaccac gcgacgtggt gcgcgctggc cgagctgcac
     1741 ggccccgact ggcgcgcgtg gccggccggg ctgcgcgacc cgcggtcgcc cgcgaccgcg
     1801 cgcgcccgcg gcgaccacct ggcgcggatc gacttccaca gctggctggc ctggctcacc
     1861 gacacccaac tggcccgcgc ccagcgcgtc gcgcaggccg cgggcatgcc gatcgggctc
     1921 gtgcacgacc tggcgctcgg cgtccacccg cacggctcgg acgcctgggc gcagcaggac
     1981 gtgctggcca ccggcatgtc ggcgggcgcg ccgccggacg cgttcaacga gcgcggccag
     2041 gactggggcc tgccgccctg gcggcccgac gcgctcgcgg aacgcggcta cgcgccctac
     2101 cgcgacctgc tcgacggcct gctgcggcac gcgggcgcgc tgcgcgtgga tcacgtgatg
     2161 ggccagttcc ggctgtggtg gattcccgag ggcgccccgc ccgaccgggg cacgtacgtg
     2221 tcctacgacg ccgacgccat gctcggcgtc ctctcgctcg ccgcgcaccg ggccggggcg
     2281 gtgctggtgg gcgaggacct gggaacggtg gagccggggg tgcgcgagga cctggccgag
     2341 cgcggcgtgg tcggcacgtc cgtgctgtgg ttcgaacggc actgggaacg ccgtggcaag
     2401 ccgccgctgc gccccgccga gtggcgtgcc ggctgcctgg ccaccgccac cacgcacgac
     2461 ctgccctcga ccgccgcccg cttcgacggc gaccacgtgc ggctgcggca gcgcctcggc
     2521 ctgctgacgg aggagcaggc ggccgacgcg ctgcgcgccg cgctcgggga gagcgccgag
     2581 tggctggagg agctggcgcg gctcgggctg ctgccgcgcg cggccggcga ggagcagcgg
     2641 atcaccgcgg cctaccgcta cctggcccgc accccggccc gcatggtcgg catctggctg
     2701 cccgacaccg tcggcgaccg gcgcccgcag aacctgccgg gcacgtggca ggagtacccg
     2761 aactggcggc tgcccgtcgc ggacggcgcc ggccggccgg tcacccttga ggagctggcg
     2821 gggtcggcgc gcgtggcgcg gctggtgcgg gccgtccggg aggagatcgc gcggcacccc
     2881 acggcggggg cgtgagcggg cggcgcgggg gcgttcgtta ctgtgggggc gtggtcaacg
     2941 tgaagaactc caagcgcggc gcgcgtgccg cgaccgtctc ggtcggcgcg ctgctgctga
     3001 cgctgatggc atccccggcg gcccaggcgc tcacgcgcga cgacggcgac gacccgggca
     3061 ccgggctgag cgtcgcggag acgatcggct acttcgtggt gaccccgatc gtgctgttcg
     3121 cggtgatcac cggcctggtc atcctctccg accgcaagcg ctgagcccgg ccgcgggagc
     3181 cgagcccggc cgggtcccgg ccgggcggtc cgtcgtgctc gcgggcggcc tcagcccgcg
     3241 acgatcagct gcggcgactg cgtcgtgagc atgatccgcg cccagccgac ctggcgcatg
     3301 gcgtgcggca ggcacgtgtc cgcgaggtcg agcagccgct cgtcccgcgt cgcccgcgcg
     3361 gcctgcccca gcatctccca gtacaccgcg ttgcccgagg ccgcgaggtg gagggcgcgc
     3421 aggtcaagca gcagcggcgg cacgtcgtcg ctgtcctccg cgccgcgccc ggccgcttcc
     3481 tgaccgcctc ctggcccgat cgcaccgccg tagcgcggcg ccgcgtccgc gatcaactcg
     3541 ccgtgccggc gcgaccagcg ggcgaggtcg gtggccacgt ggtgcacctc gtgttccgcg
     3601 cggtgccggt cggccacggc gagcaggtgc gcggcgagcg cggtctcgcc ccggtggagc
     3661 gcgttcagca ggccggcgac gcccttcatc gcgtgccccc ttccgttccc gcgccgcgcg
     3721 cgacgagcac gacgcgcgcg gcggccgtct tgtacagcgg ctgtttggag accgggtccc
     3781 agtccgtgac cgtcgtctcg ttcgccgcgc gccccggctc gccctcgggc ggccggtggc
     3841 ccgcgggggt gtcccagtag ccgtagtgga acggcgtgaa caccgtcccg cgccgcacgt
     3901 ccgcgatccg cagcacgccg cgcgcgctgc cgcgcggcgt ggtcacctcg accaggtcgc
     3961 ccgcggccag gccgagcccc gcggcgtccg ccgcgcacag ttcgacccac atgtcgggcg
     4021 cggcggcgtt cagttcggga acgcggccgg tcttcgtgcg ggtgtggaag tggtagatgg
     4081 tgcggcccgt ggtgagccgg aacgggaagt cctccgacgg ctcctcgtgc ggcggcaggt
     4141 actcggcggc cttcagcacg gccttgccct ccgggttcag cgtgcggtag gtgctcggat
     4201 cgacggaggc gccggtgatc aggtcgcggc cgtaggtctc gcacacctcg gcggcggccc
     4261 acgggacgcc gtcggtgagc aggcgttcgg tgccctcggg cacctgggcc gtgcagggcc
     4321 actggatgcc gccccgcgcg cgcagcaggt cgtagctcag gcccgtgtag tcgcacggcc
     4381 gaccggcgct gcaccgctgc cacgcggcga acgccgaggg cgggtcgtgc cacgagacca
     4441 gcgggccgcc ggaccggtcg cggaagtcca tgcggcgcgc gtagtcgagg aggatgtcca
     4501 ggtcggagcg tgcctcgccg ggcggggcga cggcctgttc cgacaggtgg acggtgcggt
     4561 ccgcgttggt gaacgtgccc gtcttctcgc cccacgtcgc cgcgggcagc accacatcgg
     4621 ccaactgcgc ggtctcggtc aggaacaggt cctgcacgac cacgaacagc cgttcctgcg
     4681 acagtaccga ccggatacgt gccagctcgg gcagcgagac ggcggggttg gtcccgctga
     4741 tccacagcat gtggagggag ccctgctcgg cgtaccggaa gatctggagc gcgggcgtcg
     4801 gcggcgccca gtgcgggatg gtcagcgggt cgacgttcca gacccgggcg aggtccgcga
     4861 cgtggtcggg gttctgccag ttcctgaacc cgggcaggtc gccgttggcg ccgcactcgc
     4921 gcgtgttctg cgcggtgggc tgcccgttca tctggaggat gccggcgccc gggcggccca
     4981 ccatgccgag cagcaggttc aggttgttga cctgcaccga ggccgccgtc gcctggtgcg
     5041 actggtagaa gccctggagc acggtgctca gcaggcgccg ggcgccgccg agcagccggg
     5101 ccgccgcggc gatgtcctcg gccgggacgt cgcagatctc cgccgcccac gcgggcgtgc
     5161 actccgcgac ggcggcgcgc agctcgtcga atccgacggc gtgctccgcg acccggcgct
     5221 catcgacgtg accggctctg atcacctcgt gcagcagcgc gttcatcagc gccaggttgg
     5281 tgccggggcg cggcgcgagg tgcacgtcgg cgcgccgggc caccggcgtc gcgcgcgggt
     5341 ccacgcacag caggcgcggc gggtcggggc cgtcgagccg gtcgaggacg cgcatccaca
     5401 gcacgggctg cgtctcggcc gcgttgtgcc cgaacagcgc gatcgtgtcc gcgtgatcga
     5461 catcggcgta ggagcccggc tggccgtcgc agccgaacgt ctccttcagc gcctcggccg
     5521 ccgtcgccgt gcacaaccgc gtgttgccgt cgatgtggtt ggtgccgaga ccggcccgcg
     5581 cgatgaccgc gagcgtgtac gtctcctcaa ggaacagctg gcccgaggtg tagaagccga
     5641 gcgaggaggg gccgtgctcg gcgagcaggt cgcggctccg ttcggccacc aggcccatgg
     5701 ccgtgtccca gtccgcctcg accagccggc cgccgcgcct gaccagcggg tgggtgagcc
     5761 ggtcccggga ggcgttcgcc tgccacccga agaggtcctt ggggccgaga cgcccccggt
     5821 tcacccggtc gtgggcccgc ccgcgcaccc cgacgatgcg gcccttgcgc accgcgatgt
     5881 ccatcgcgtc gccgttggag tgcagcaacg aggccgccgg cacccagcgt tccaccgtct
     5941 cccgcgcgac cccgggcgcc aggtgggtgt ccacccgcac cggccagggc tcgccccgcc
     6001 cgtacggggt gcgctcaccc cacgggtcga cgatccgtcg ctcacgcgcc gccattccgc
     6061 acctccgccg ccgtcggcat ggccccgcgc cggggcccgg ggccggttac cccgccgccc
     6121 cgccatcgaa aaccgcgcgg cgccgccgcg ccgcgcggac gcggggcgcg ccgttcgacc
     6181 tcacccggac ggcccatgcg ggagcgggaa cgcgggggcg gcccaagcgg gtgaagtggg
     6241 aggaatgccc gcggtggccc accggtgtgc tgacgcacag gccaacgcac gttaacctgc
     6301 ccggggttga ccgtgacgag gcgggccagg cccgggcccg gcccggtggc cccgggcgag
     6361 ttcgaaacga gaggtgtccg atgagtgcgg tgagcggcgt gagtccagag gagccggtgg
     6421 acctgcggac ggaccagccg cattccgccc ggatgtacga ctacctgctg ggcggcaagg
     6481 accactacgc ggcggacggc gaagcggcgg agaaggcgct cctctcgttc ccgctgctgc
     6541 ggaccgcggc cagggagaac cgcaagttcc tcggccgcgc ggtgagttac ctggtgcgcg
     6601 aggcggggat acggcaattc ctcgacctcg gctccgggct gcccacggcc gagaacgtgc
     6661 accaggtggc gcagcgtgag gcccaggacg cacgcgtcgt gtacgtcgac aacgacccga
     6721 tcgtcctcgt gtacggcggc gcgctgctgg ccagggacgc gaacacggcc gtgatccagg
     6781 gcgacatccg cgacccgcgg tccgttctcg accacccgga gacgcggcgg ctcatcgact
     6841 tcgaccagcc ggtcggcatc ctggccgtcg ccgtgctgca cttcgtcggc gacgacgagg
     6901 acccggcggg catcgtccgc acgctgtgcg acgcggtacc cgcgggcagc cacgtcatcc
     6961 tgtcccacgc cacggccgac atcgcgcccg aggccgcgct cggcgtgcag accgcctacc
     7021 gttcgcaggg cgtgccgctg acgctgcgcg acaaggggca gttcaccgcg ttcttcgacg
     7081 ggctcgacat cgtcgaaccg ggcatccagg tcgtctccga ctggcgcgcc accgtgcccg
     7141 aggccgagcg ccccgcccac gccgacgtct cgtggtacgg gggcatcggc cgcgtcaccg
     7201 gctgaccgcg gcccgccgcc cccggcggcc cgtgaccgcg cgggccggga cccctcccgg
     7261 cccgcgggag tagaactgcg gatctgctcc ggaggtggtc atgacgcaca gacgaacgtt
     7321 cctggtcggc gtactcgtgg cggcactcgc cgccgcgtcg gccgggtgtt ccggggacgg
     7381 gaacgccccc tcgggcagcg ggtccccgtc cccgtccccc gccccgcccc cgtcggcggg
     7441 cggctacgcg tacgtgaagg tcgagttcgg acagagctgg acggacacac agagccaact
     7501 ggtcgtcatg gacggcggcg aggagatcgg ccgcagcgat cccctcttcc tcgccggccg
     7561 cccgctgttc accagcgacg gccggtacgc gttcgtcctg ccctccctcc tcgacgagat
     7621 cgtcgtgatc tcggccgaca ccggcgagac caggtccgtg ccgtgcgagg gctgcgaggc
     7681 gcgccagacg gaatgtcact gccaggtcgt cgcgcccatc ggcggcagcc ggatcgcgtg
     7741 gctcgacggc gggaaccggc tcgtggtcac cgacctcgcc gacgccgcgc cgacaccccg
     7801 gcccacggac gtcacgctgc cggaacagga cggcttcctg gacgaacggg tcgtcccgaa
     7861 cctcatcgcc ggcaccgagg gcgcggccct ggccgcctac ccgcacggct cgctggcggg
     7921 cgacgacctg atgcccgcgt tcctggtgac cccggacgac cagccgcgcc ggctcgaccc
     7981 gcgacggccg gacgccatcg aggaggcggc cttcagcccg gacggcaccc gcgtggcgct
     8041 gacgggcaac caggagtaca cgtgcaccac ggtgaccgtc gtcgacgtcg cgtcgggccg
     8101 gggcgggacg gcgcccgtgc tcgcggcgcc cggcaccgag tgcgagggtg tcgacgcgta
     8161 catcgacggc atgtggtggg accccgacgg cggcctgcac gtgacctacg agaccgacga
     8221 gggggacacg tggtcggagg agagcaccgc gcccgaggag ggccagcggc ggctgcacga
     8281 ggggcgttgg gtcgactccg acgtgggccg ggccaccgag cggcggcaac tgagtgccgg
     8341 cacggcgacg atccgaggtg acgggacact gctcgtcgag agcggcggcc gacagaccga
     8401 gatcgacacc gacgtccgct acctcatcgc cgccccgtag gcccctggcc gagcggcggg
     8461 tggggcgttg tgccgccggt gtcaggagcg gcccagcagg tccccgcaga acgaccggat
     8521 ggaacgtctc ccgccagatg gtgatgagcg gttgcgcagc cctgtcgttg ttcctgaggt
     8581 cgattcgccg cccccccggg aggcaacgtc ggcgccggcc gggtcgtaac cgatcgcgcc
     8641 ccgcttgaat tggggtgggg caccctccgc accgtcgagg ccttcgcagg tgaagtacgc
     8701 cggcgatgcg tcaggtgtgc ggtgccccag tctcctgcgc ccgcgcgggt ccggagaacc
     8761 ccgcgggcgc ggggcgcagt ttgtagtcgc cccaactccg ttgccttcag cgggagcaac
     8821 cccgcgggcg atcgtggggg caggccaggt tctttcgtat caccttgtta ctgagctgga
     8881 gggctcgcgc cagctggtcg aactcgggct ggggcaggtg gcggcgggcc agcgcgcagc
     8941 tgtgcacaag gtcgcggacg atctgagcgt cggcgggctt gaccaggtcg gtgaagcgct
     9001 ggtcggccag gcactcgcgg gcggcgtatc cgtcggatgt gttgatggct cggtgatgca
     9061 acttctgggc aatacggcat gcggcgacat cgtccggcgg ctcgatgagg ttcaagaggg
     9121 ttaggccgag gcgggtgtcg aagacaatgg tgccggggtc gggctggtgg tggaggtacg
     9181 cctccaccag ttcggaaaga aggggctcga cggggcggtg cagacgccga cggcacatca
     9241 ctgtcagaca ggacgttacg gcttcttccc acgcttcgcc gggtgccgtc tggtttacga
     9301 ggtcggctgc gtgggccggg tctcggtgca gtgcggcgag tacggcgacc tgacggccgt
     9361 cgagcatccg ttgcccgatg ccgttgtgct gcttgagatg gtgcagggcg tcctcccaac
     9421 gtcccgcgct ggtcagggcg cgggtgccgt cggccaggat cactcgccac agccaggcgc
     9481 gtacctcgtg gcggtccgtg tcgctgatgg tcaggtccgc cggtatccgg gtgctctgga
     9541 actgggtgta ggtcgcgtcg ctgacggcgt ggtagagcgt gagaaggcgg tgccgaccgt
     9601 cgtcggtgtt gcccgcgcgg atgtcgaggc gggcgaggtt gaccacgggt tcgagcgccc
     9661 ggactgcgat ctttcccggg agcggcgcgg cgtgcaggta ggcggcggcg tgttggtggc
     9721 accactgccg tgcgagttcg ggaagctcga ggtcggaggc gaggagcgcg gcttggttgt
     9781 agaccgcgga ggccaggacc gggtctgctc ccgctgtcgc ggtgccggcg aggtcgacca
     9841 gggcgtggac gcgtcgtgcc aagggcaggc aggccgggcg ggtccgggag acgagcggga
     9901 aacgccgggc taagaagccg tgcgggtcca ttggtcgggc ctccccggcg gtgggcagcg
     9961 aagggcagcc cggggcggcc ggcgtgagga gacgggcacc tcaggcatca cggctgcggg
    10021 ctccagccgt tgacgcgggg ttcttctcgg cgctggggtc agagccgaag gtcatggtct
    10081 tcgcggctgc cgtgagggtg gcctgtgcgg tgtaggacag gccgagtcgg ttccaggcaa
    10141 agatcacatg atgggcgagg acgtcgcgga gcccgcggcg caactgaccg gtcccgttga
    10201 ggtgggcaag gtcttcgccc gcgtcggtgt aggccgcgcc ccaatcggtg tgctccgcca
    10261 ggggcccgcc aggctgcact gcgtactggg agtcgacgga gagcaggcgg tgaacggcgg
    10321 tgtgcaagcg gtcgccgtgg tgctgcccgg agtccggtgg cggagcgcgg tgggcggcga
    10381 cgcgcgccca gacgtcgccc tgctcatacc agtccagccc ggcggcgcgc atcatgaggc
    10441 tgcacagcat cagggaagtc tcgcggcggt gtcgaacggc gccactgccc aggaactcca
    10501 gaagagcgcg gctgtcgcgg tggaagaagc ggtgcgcgga gtccatggac tgggcgccgc
    10561 cgaaggcgtg gacttccggc tcgtagatga tctcggccca taccgtggcg tggccggcgg
    10621 cgaccagttc gtcgaggtgc tgatcgaggg cgttcggtgc tccggcgacg ggcgtgtagc
    10681 ggacgcgcca gcaggggcgc ttgcggatga tgaaccacgc ggtgatggtg ccgacggcct
    10741 ccgcggcacg caggaacggg gcgatgtgtt tcaccgcagt ggtctcggcg tgttcccagt
    10801 gggggaactc gacgttgacc tgacgccagg tgggctgggg catgaagtgg tcctccaggg
    10861 tcttcaggcc agggcgagga aggtgtccca gtggggagcg ggcgcgtcgt tcgtcgcgag
    10921 agtgtgcagg gcgagtgccg caccggcggt cccgtcgagg agttccgggt cgtgcttctt
    10981 cttttcgagc tcggtgatca atcgtccggc gaggggcggt agttctgcgg cgatctcggc
    11041 gttgtccgtc tcggtggcca tgcgccatgc tgcttgcagc aggccggcca tgccgtggca
    11101 cagcccgatc tcgggcagca tggcgcgttg gttcgggtcg cgcagggcgt cgaggatcgc
    11161 gttctcggcc agctgcacgc gggtcgggtc tcggagggcg agaccggcca gttgctgggc
    11221 gcgtgcggtg ccgctggctc cgtagcacca ggagggccgt ggcctgagtt cggcgtggac
    11281 gtggtgatcg gccgcttgct gcgcgctgat cagcccgggc caccaggggc aagcgtcatt
    11341 gccctgccgc cagcggtcgg tccaggagca gatccgttcg acggcgtcgg ccaaaccggg
    11401 catggccagg ccgcagagca gtgcctgcga gagtacggcc aaggccgcgc cgatgccgtg
    11461 ggcgagcccg aagttgccgt gcccgtccgg gaagtcggga tgggaggcgc cagtgggagc
    11521 gacgttcatc caccagggtg ggagtccggc ggggtcggac aggggctcgg tcagccgtac
    11581 caggtaggcc agagtgtcgc tggtgatctc gtggtgacgg tgacggctga ggtggtaggc
    11641 cgcaagtccg gacagcccct gaatcaggtc gaactcttcc atggggggac gtgcggcacg
    11701 atcgatgcgc aggtgggccg cggtgagccg ggcacgggtg acggagacgg tggccgagtc
    11761 caggcgttcc aggagccgca ggtagcggcc tgacgcgctc gccgcgcggt gcgtcacgaa
    11821 tgcgagggcc ggagcgccga agtacaggtt ggcgttgtcc gcagcgctga cttcgccgtg
    11881 cacggccgcg gtgagccagg tgtgcgcggt gctccaggtg ccgtggccgg agcgggcccg
    11941 ttcgatgtgc agcagggcga ttccggaggc gcctccggcg agcgactggg gccaggcccg
    12001 tccgccggcg ggtcggccgt tgggccacgc ggtggtcggg tcggccaggg cgtcggccag
    12061 cttgtcgacg gtcgaccgcg cggcagaggg aggggctgtc gcgctcacgc ggttctcctc
    12121 gctcgtgctg tccagctcag ggcggcagcc cgggccaagt gcaggtgcgc gcgttcctgc
    12181 ggcaggccgg gcccctgcac ccgtacgtgg tgcaggtgca ggagatcggg cagtagatcg
    12241 ccggggtcgg tgtgcgctgc cgtcagtgcg tgggcgtagc cggccagcgc tgctcgtcgt
    12301 gccgacgagg ccgcgacgat ccgttcatcc acaccggcgg ggtacgtgtg caccaggtcg
    12361 atggcctgtc ggtagaccgc ccgagacggg gcggccgtgt cgctccgggt gtgttcgatg
    12421 agccagcgca tggcagtggc acggtcgccg agcaggccga cggcgatctc caccatgctg
    12481 gcggcggtca ccgcgcgggc gtccggagcg cccttcgctc cggcggcggt gagttgggcc
    12541 agagccgcgc aggagtcggc cgcgaaatac cgttcggcgg cgtcgatcgc ttcggggccg
    12601 ccgaaccgcg cggtctccgg atggtaggtc tccacgctgg aacgagtgat cagcccgcgg
    12661 tcgcggaggt gctcgctcca ctcgccaatg ctttcgaacg tcttgccgag ggttccgggt
    12721 gcgcaggtca ggcggatacg gaggtgatcg tcagggtccc ggtagcgcac gaaccagcac
    12781 cggacgtcac ccagctcgct gagcagggct ggcacatgcc gggtcaggac ggcgtcctgc
    12841 cgatcttggc gtccgtgaag ttgtaggtag aggcggtctc cactgccggg caggtgcccg
    12901 tgcttgcgag gggagaagtg gggggtcgac cgtacgggag cgcggttctg ctccgtgaac
    12961 atgggaatga cgacctcgtg cgagcggtcg tcggcccacc ccgcatcccc gggcccggga
    13021 gcggggtgca gggttgccgt gccgtggcgg tcgagatgcg cacgaagcag ggcgcggtgg
    13081 gaagactcgg ccaggtccag ggcgatgcgc tggtcggcat cggtcaggta cacgcgctcg
    13141 gggaggcgcg cgtcgccgct ccaccgggtc agggcttcgt cccattcctg ccagggtgcc
    13201 gaagtgccgg gaagttcgcc gttggtgagc agccagcgag ctggggacag gaccgtgcga
    13261 ccgtagcgca gcgcgggcag gaacggcagg tgcgaagctg cggcgcccca caggaatccg
    13321 gtgcagggga cggtcagcgc gaccggtgcc tcggccagga aacgggtgag cgggtgggag
    13381 tgcagtccca ggtccacggc gttgagcaac agcgtgtgca ccgggcggcg gcgggagagc
    13441 gacacaaggt ggagttgttc ggcatctgcc gtgacggcaa ggtccgcgag cgggattgag
    13501 ccggtgctgg agccgcggta ctcgcccagc gagatcacca ggtcagtcgc ctgcggggcg
    13561 cgcgcgacgt tctgtgcgcg gacggacagc ggggaggcgc tgagttgggc gacgaccgcg
    13621 tctcggtgca ctccaggcag ctcggcgtac accatggtca tgcgacggcg ttcctcgtcc
    13681 ggcagcaggt cgaggaagcg gccggtggtc gctccggccg aacgggccac gccgacgacg
    13741 tgcaggacga agtcgccccg ctgaagcgcg gtggcatccc tggcttcgat gcgtacggtc
    13801 acctcggtgc tgggttggac gggatggctc tggtcggtgg tggccagggc ctccagcgca
    13861 tcgtcgtcga gcacgatctc ggtgcggccc cgcacggcgg cggcgtgggc gagcttgatg
    13921 aggcggccgt cccggtcggg cagcggggag agcgccggcg cggcggtgga gccccggtag
    13981 ccgggcgggt atcccagcac gtcgaccact tccagaacgg gcacggtcgc ccgcggcccg
    14041 taccggtcga ggaaccgcgc gtgccactcg gcccacccgg tcagggcggc gcgcggcgcg
    14101 agtcgagtga gcgccttcgc cgccttggcg gcctcgtgcg ccaccgtttc cgggagggtc
    14161 aggtgccagt ccagacggag atcgacaacg ggccggtcaa cgtcgctcag ctcggccctt
    14221 tcgccggggg acaggtggtg tgcatggtcg tcgaggccgc tgagcgggtc ggccgtggtc
    14281 atcgtggggc ggaggctggt gagcaggacg cgttgtcgga ccaagcccgc gagcagcttg
    14341 tccactgccc ccggcggggc gtcggggaag tcgacggcga gcttcgccga gagatcggtc
    14401 cagcggatcg gttcccgcgc gccgtgcaga atcgcgcgca cgggccctgt cacgcggatg
    14461 cgcgcgtgct cggggccggt gttccgtctc ccgctggggc ggtgctcaag caccacgtgc
    14521 ccgtcgtgct cgacggccag gttggaggcg agcagcatga ggtgcggccg aagcgctggg
    14581 tgctgctcga agcggtcgac gaggaccgtg ctgcgttcgg cgtctgctct ggccgaagaa
    14641 cagtgcgcgt gaccgaagcg cacatcggtc ctggtgccta tgcgcgcggt tgcgattccg
    14701 gcgaacaggc cgaacggcgt ggcgcgcgtt cgggcacgga gcaggtagcg cagcacggcg
    14761 agcacggtac ggcgcacgtc gacctccggc agcggacggc cggcgcagac ccgttcgacc
    14821 tggttcgcga ggtcaggact ggcagcggtg acggcggcgg cgaactccgc gtcggcccac
    14881 atctgctgta gccacactcg ccacgacatc gcattcgcgg cgccgctcac gaggtcaggc
    14941 cagtcgatcc gctggtcgcc gcggatggca gcaccccgga tcagcgctgc atcggcgtag
    15001 cgatacatat gcccttcctg tggccgtacg gcgtccggcc gcgtccgttg cgcggctgcg
    15061 accggacacc gcgaactacg cggtcggtac tgctacgggc agctcacgca cgcggtggcg
    15121 cacgtggagt tgcagccgtc gcccgtcaag cggatgagct ggtccgcggc ggggccgccc
    15181 tcgacgatgc tcacgtcgag ctcccagtcc gccggttcac cggacgacat caggacaccc
    15241 gccgaatgag cggatgtcgc gagactttcc attggcactt ccatacctgc ctccttgggc
    15301 atcgaggagt ggtgcacggt tccggaaccc accggctccg gagctttcag gcccaggtcg
    15361 ccgtgacgat gccgtgtcga cgcggcacgg cggcctcggg caggggggtc ggggcgggcc
    15421 ccggcaggta gcggagcgtc gcggctcccc gtcggcggtg gttctgcgcc cagcggcgga
    15481 ggaggtccgt gtactggtcg gccagcgctt cggcctgcgg accgtgggcg atgacaccgc
    15541 tctcgaaccc gccggtcccg gcgttctcac ggcgggtgcg gtaggcgatg ctgtcccggc
    15601 ccaccagggc gggcacgccc ctgagggcgg aggcttccac gagcccgctg tccacgatgc
    15661 ccggggcggc gtggagccgg gccgggctgg acaggttcag cgtgaggaac aggtccagtt
    15721 cgtccggcag gtcgtaggca gcgccggacc agcgttccag ccgggacccg tccagagccg
    15781 cgttgagtgc ctggggcgcc aagggcaccc gcgcgtcgtc ggtccgcaac acgacgccct
    15841 cccggagcat caccttgcgc tcgtcggcgg cgccctcgcc ctgcatggga acgaagttcg
    15901 ccaggcggta cgagtggctg atgaggcgat tcccgtcgcg gtcgaacgcg atgctgcggg
    15961 tcgtgccgtg caccgtgagc gggacgacga tcctgccctt ctccgtaagt ccgctgatcc
    16021 acgacggcgg gatgtcccac gccgcagcgg tcacgatgat ccggtgatac ggagcgccct
    16081 cgggaacacc atgctcaccg tcagcaagga cggtcttcac ctgggtgtac ccgacgtcat
    16141 cgaggcaccg gcgggcccgg gcgaggacat cacggtcgat gtcgacggtg gtgacctcgc
    16201 ccgcggtacc gaccagttcc tgaaggtaag cggcgttgac cccaccggaa ccgatctcca
    16261 gcacgtgcat cccgggttcg atgtcggcct gttccagcat gacggcctgg aggtgtgcgg
    16321 tggacatgac gctgacgtcc gatccgtgct cgtccttttt gaccggcacg atgctgtgca
    16381 ggctgtaggc cacctccggc gacgcgtccg gtgcgaacct gtgccgcggt acggtgctga
    16441 acgccgcggc tacgggctcg gtcctgaccc cgtcctccgc gcggagcgcg cggaccatgt
    16501 ccgcgcggag tgcgtccggg ctgcggacgg tggagtcgtc aatcgcggtc atccgattac
    16561 ctgttcctgt agtggagatg ctgacggcag tcgtgcttgg cgtcactgaa acgctaccca
    16621 gggcgactat ccctgtgggc ggatacgcgc cttcaggggg gatcacactg gcagttcggc
    16681 tgaaaactgg ttcgagcgct tatcggctgc gctatcgggc gggttgtagg catggagaga
    16741 ggccgttgag ccagctcacg cccgttcggc cggtgctgct gccacagtgg aagaggcttc
    16801 tcgaccctgg catcgtcgag cgatggatcg aggggcgagg gtccgcagcg agggcgcggc
    16861 tggtgatcac caggggcggc cccgggggat gcgggggtcg tggcggcggg cggcccacag
    16921 gatggtggtg cggttcatga cgaacgtctc gcccgagtga aactccagcc gtttgcgccc
    16981 agcccccagc gcggtcaagt cgcgcaccac gaagctctgg ccgccgatca tgacctgatc
    17041 cccgacggcg accgtgcggg cgtcgatctc cacggcgacg agcacccccc tcaccggttc
    17101 gcctcctcgc ccggggcggg cccgggctcg ggcgcgggcg gttccgggag ggggccgatg
    17161 cataccttgg ccgcgtagat cagggcgtcg cagctcgggc agtgcttccc gtcccaccgc
    17221 gacaccagct caccgccatg aagacatgcg gatgtggaca caacaacgct cctacgggac
    17281 gagaacgaag taggcgaccc acaggaaggc cagaacaacg cagttcaccg cgatcagcag
    17341 ctcaccggca cgcccacggc accaccgcac ggcccgggca aggcggcgcg gacggcgccg
    17401 gtgccgcgca cggccgctcg ccgccgcgtt catcgggcac cccgcaacgc gtcgagcagg
    17461 acgccggagt cggtcaggca cacggcgttc ggagggatcg cccaccagac gaccgaccag
    17521 cgcgggtcga gcgcgtcagc gggtggcacg aggagcgcga gcccgcgccc gaggacctgc
    17581 acgcccagca gcccggcgtc ccacccggcc gtcgcccccg ccgggaccaa ccacgtcatc
    17641 gtccgcgcga accggtcctc gaccaccggc ccggaacggt cccgcagcac accgacgaca
    17701 cgcgtaccga caagcgacgg agcgcgcacc gcatcccacc actgaccaga aggcaggact
    17761 gccgcgagcc cggagggcgc ccactcgggc agacccgccc cagacggtcg ggcagctctg
    17821 tgcacatctc tcatgcagca gaacgctacg gagggtggtg gcgcgaatac agggccgaag
    17881 cgtgggccag cgtatgggcc aaaatcaggc gaccggggga ccccactcgg ccagaacctc
    17941 ggccacctcg ggaacggcgg cgtgtgggcg cagcgcggtc agcacggcct tggaccgggc
    18001 cgctgcccgt gcgctgggca cgctggcgga cagctcaagc gtgcgccccg ctgcggcagc
    18061 ggcctcctcg ggctccccgc catccagcag actcgtggcc agccaggagt agtagagcgc
    18121 caactcgcga gtgtggtcgg ccgggtagtc ggcaagaacc tcccgcagaa gcggcacggc
    18181 tctcagcggc cggcgcgcga ccgtgtacac ccgggcttcc atgatccgcc gttcgtcgtc
    18241 cccgacccag taaagccagt gccggtcggc gtcatctccc ggctcgtgct cggccagagc
    18301 ctcggcggac tccccgacag cacgaagcgc ggtctggacg tccccggccc gcacgctgca
    18361 ccaggcggtg cgatctgcca cgagggaacg ggcgcgcggt ggcgcctcgg ggccggactc
    18421 ggtgccgagg cgaagcgcga ggtcgcggcc gaggctgtga tggccgcgat tggtctcgaa
    18481 gtaggcccag gaaccgagca actggccgag cagcggcctg tcctccgctt cccgtgccgc
    18541 cgccgcgccg agccggaaca cccgggcgac gtccgggccg ttcgtcacgt cggatgccac
    18601 ccaaccggcg agctgtgcga gctcggcgat gccgaccagg agtcggcgcc cgacgggttc
    18661 gctgtgcgag ctggcgttga acaactcgcg cgcggcgttc aactcctgca tggcggcgtc
    18721 gaccaggtcg ccaccggcca cgagatcatc ggccagccgc agagcgtgtg cccgacgcag
    18781 tatgcggtcg gcgtcccgca tgcccacgcg ggccccggcc cgggtctcga cggcggccag
    18841 tggctcgtcc ggcggcagca agtcccggag caccgcgtcc actccggtgg gctgcgggcc
    18901 acgcacccgc cgccgagccg ccttgctcgc ggcccgggcc cggcgcagcc gttcctccgg
    18961 aacgcccagg gcctcggcca tggcgggcag ccagtacggg ccgatcagcc gtacctcacg
    19021 ctcccagcgg gagatctggc cgacgtcgag tccgccgtgc gatcgcggct ggtgacgttc
    19081 cgccgcggct gccagttcgc cctgggacat gccggcgtcc tcgcgcaggc gccggatcag
    19141 gctccccagt cgctcgacgt cctggttggc gcctccatcg ggtgacatgc tgaactccct
    19201 ccgtagcacg gcactcggga cggtaccccg tcgtgagggg ccggaacagc acgacggccc
    19261 aaccggtgga ggcggtgtcg tcgtgcttcg cgaggccccc ggttctttca ccgtccccgt
    19321 ggctgggggt ggggaacggg ggccgggggt gagcggtcgg tgtgccgtct tcgcccccgt
    19381 acccgcgact catgggcttt ggcgccgttg ccgtccgagt gttcgactcc tcccgggtcg
    19441 gtttcccgtt ccggcaaaag cttggtcctt gccatctcag gggagtcgga gaaggctgga
    19501 acagcaacac gagtcaaggg aggtgcagtg gaacttcaga tgctcgtcac cgagtgccct
    19561 gatgcctgcg acaagaagga ttgcccgacc ctctacgcta ccgacagggg aacgcttctg
    19621 gtccgtggcg atctcaccga cgaacacaag ttggagttgc ccgcgcatga aggtgtcgtc
    19681 gagatccagc tctcgttgat caagaaggcg attgcccgtg gccacctctg acaccagaaa
    19741 gcccccgacg ctcggtgagc tgttcgactc cttccgccgg gaggcgttcc ggttggagac
    19801 gctcgacgac tacagcggct cggggagcac ggacgcctac caggctttcc tggcaggtga
    19861 gaagaagccc gacagctaca actccgactg gatctccgaa gtcagcggcc atgtcggcga
    19921 gggtaagcgg atctaccggg ttcatgttct gtcccgtccg ctcacgccct atctgcggtt
    19981 cgaactcgga tggggctaca gaaccaacgc gaccgctggg gaggattttt tcatcctgga
    20041 cgtcacggac agccccaatc cggtcgcggg gatcggggac ttctggatgt tcgacgaaaa
    20101 gttctcggtg cccatggagt accgagacgg aacgatgacc ggctacgcag tgctcaccgg
    20161 tgtacgggcg caagagttcg tcgggtatcg agacgcggca ctcaggcacg ccgttccctt
    20221 ccaggactgg tgggaacagc acgccgagtg aataagggag aacttggggc ggcgctccgg
    20281 gcattgcgtg agatctccgg tcaaccgggg aaagcggttg cccggagctc tgtcatgtct
    20341 gtcagtaagc tgagtaaaat cgagacgggc aagctgaccc cgtccattgc cgatgttgag
    20401 cgcatactga ctgctatcgg agtgtcggaa gaggtcaagg ctgaatacct tgagcttgcc
    20461 cgggaggaac ttaccgaagt cacggcctgg cgcatcattc agcgtatggg tctgcacaag
    20521 gctcaagagc agacgcgagc actggaagcg cagatgacag tgcttcgctt gttccagtcg
    20581 gctctgattc cgggcctgtt gcagacgccc gaatatgtgc gggccgtcct cgggcgtcat
    20641 gggctcaccg aggaagtctt caacaggacg actcaaacgc gcctggcgcg acaggccatc
    20701 ctctacgagg gcgacaagga gttgcacttc gtcatcactg agactgtact caggtggcgc
    20761 atagtctccc ctgcgagaat ggttgaacag ctcgatcgcc tgatttctct gtcgagattg
    20821 accaacgttc acatctccgt aatccctttc gaggccgcac aggatgacat tgccagccat
    20881 gctttcgtca tacgggacga tcgcacagta acggtcgaga ccgtgcatgc ggagatcgtc
    20941 gtgaccgatc ctcgcgacgt ggcgctttac gtggcgaagt tttaccgatt cgagcgcaac
    21001 tctctccagg gcgacaagat gcgcgccatg ctcgagaagc tgcgcgacga gctgctgcga
    21061 gaacagggga gcggctgaat gacacttctg cggatgtcct ttgcgggctt ccgcaccgtc
    21121 gatcacgtgc tccgtggccg cgcccgcacc ggcggggccg ccgtgccccg cgccgcgccc
    21181 cggtcccgtt cccctgccgg gaacgggacc ggggcgccgc cgggggcggg cggtcagtcg
    21241 gtcgccgcgt cggcggcctg ggcggtcagc gcgcgttcga tgcccgcgcg ggactcggtg
    21301 accaggcggc gcagggcggc cgagggctcg gcggtggcca gccaggcgtc ggtgacctca
    21361 agcgtctgcc gggagacctg gatcgccggg tagagcccga ccgcgatctg ctgcgccatc
    21421 tcgtgactgc ggcccgccca cacgtccttc agggcggcga agtacttctc cgtgtacggc
    21481 gccagcaggt cgcgctggtc ggtctgcacg aagccggaga tgaccgcttc ctgaagggcg
    21541 ttgggcagcg tgtcgccctc caccaccgac gcccacgcct cggccttcgc ctcgggcagc
    21601 gggcgcgccg ccctggccgc cgccgcgtgc cgctcgcccg ccgacgtggc gtcgcgcgcc
    21661 agctcggcgt cgatcagggc cgtgtcggcc cggcccgtgg ccgccagccg ctgcaccagc
    21721 gcccagcgca ggtcggtgtc cacggcgagc ccttcgatgc tctccgagcc gtcgagcagc
    21781 gcggccagca ggtcgagctg ttccccggtg cgcgcggtgg cgatgaacgc ccgcgcccac
    21841 gcgagctggt ggtcgctgcc gggcgcggcc tcgcgcagcc gttcgagcgc cgcgtccgac
    21901 caggtcgcca ggcccgtctc gcgccactcg ggcgccgcgt acaggtcgag cgcgagcttc
    21961 acctgccggt gcagcgtctg caccacgccg atgtcggtct ccttgccgat gccggacagg
    22021 accagcgcga ggtagtcgcg ggcggccatc tcgccgtcgc gcgtcatgtc ccacgccgag
    22081 gcccagcaca gcgcgcgcgg cagcgactcg gtgaagtcgc ccaggtgggc ggtgaccgcg
    22141 gccatcgagt cggagtcgag ccgcaccttg gcgtacgaca ggtcgtcgtc gttgagcagc
    22201 agcacgtcgg gccgtgcccg gccgacgagt tcgggaacct cggtcagctc gccgtcgacg
    22261 tcgagctcga tccggtcggt gcgctccagc cggccctcgc gcagcgcgta cagcccgatg
    22321 gcgatgcggt gcgggcgcag cacgggctcg cccgaggccc ccgcgggcag cgcgggcgcc
    22381 tcctggcgga cggcgaacgc ggtgatggtg ccgtccgcgt cgaccgcgag ttcgggccgc
    22441 agcacgttga tgcccgcggt ctcaagccac gcgcgcgacc aggacttgag gtcacggccg
    22501 ctggtctcct caagcgcggt gagcaggtcg gtgaggcggg tgttgcccca cgcgtggcgc
    22561 ttgaagtacg cctgcacgcc ccggaagaac gcgtcctgcc ccacataggc gacgagctgc
    22621 ttgagcacac tcgcgccctt ggcgtaggtg atgccgtcga agttgaccag cacgtcgtcg
    22681 aggtcgcgga tctcggccat gatggggtgc gtggacggca gttggtcctg ccggtaggcc
    22741 cacgtcttca tctggttggc gaacgaggtc cacgcgtgcg gccagcggct gccgggggcg
    22801 tgcgcctggc aggcgatgga ggtgtaggtg gcgaacgact cgttgagcca caggtcgttc
    22861 caccactcca tcgtgaccag gtcgccgaac cacatgtgcg ccagttcgtg cagcacggtc
    22921 tcggcccgca tctcgtacgc cgcgtcggtc accttggacc ggaagacgta ctggtcgcgg
    22981 atggtgacgg caccggcgtt ctccatggcg cccgcgttga actcgggcac gaacagctgg
    23041 tcgtacttgg cgaacgggta cgggtggtcg aacttctcct ggaaccagtc gaagccctgc
    23101 ctggtgacct cgaacagggc gtcggcgtcg aggtgttcgg cgagcgaggg gcggcagtag
    23161 agccccagcg gaacggaccg gtccgcgccc tcccagctgc tgtgcaccgc gtggtagggc
    23221 ccggcgatca gcgcggtgat gtaggtggag atgcgcggcg tgggctcgaa gcgccatacg
    23281 ccgttctcgg gttccggggt gggggagttg gagaccacgg tccagccctc gggggccgtg
    23341 acggtgaagc ggaacgtggc cttcaggtcc ggctgctcga agcaggcgaa cacccggcgg
    23401 gcgtcgggga cctcgaactg cgtgtagagg tagacctgtt cgtccacggg gtcgacgaag
    23461 cggtgcaggc cctcaccggt gttggtgtac gcgcagtcgg caaccacgcg cagctcgttg
    23521 gccccctcgg ccacgtccgc gagcgcgatc ctggagtcgg cgaacacctc ggccgggtcg
    23581 agggccgcgc cgttgagcac cacctcgcgg acccggggcg cgatcaggtc gacgaagacc
    23641 ggctccgcgg cccgcgccgt gaagcgcacg gtggtctcgg acctgaaggt gccgccttcg
    23701 cgggcgcctg agaggtcgag cgcgatgtcg tagctgtcca caccgagcag ccgtgcccgc
    23761 tcctgggcct cctgccgggt cagattcgtg ccaggcactg atggtctcct tcttctgcgt
    23821 gtcgcctgcg ccagtcttcc acgccggaac gcgaaggggc gggcgagcgg cccgccggcc
    23881 gcccgcccgc ccctggcgcg ctccggttac ggagtgacgt ggtggatgac cagctggccg
    23941 ctgccggtga gcgtgccggc ctcgttcagc agccgtacct cgccgaacac ctcacgcccg
    24001 tgcccggcct cggccgccgc ggcggtcgcg gtgatccgcg ccgggatcga cgtggtctcg
    24061 ccggtgtcca gctcgatcac gcggtcctcg tcgaccgtga tcacgccgag cccttcgctg
    24121 aggtaggcgt cccggtacgc gtaggtggtg gtgccctgcg gcaccgagta gccgtgcacc
    24181 tccacggtgt acgtgccggg ctccggcgcg tcgagcctga tcgtctcctc cgagcccgag
    24241 ctggtcgagc tgtccaccag ctcgccgtcc cggtacacga acaggtcgag gtcggccccc
    24301 gggtcggcgg gcgagccgat cgtcgcggtg aacgaggaga cgccgtcgcc gagcacgacc
    24361 tcgttcgtca ggtactcgcc gtgcccgatc tccggggtgg cgtcgagcgc cgagcccagc
    24421 tcgcccgact ccgcggtgcc cgtgagcggc gcgaagtcgt tggtgatgcc ccaggcgacg
    24481 ttggcgggga cgcccgcgtc gacgtggccg agttcgaggg tccgcgggtt gaacgtggtg
    24541 ccgagcgccg tcgcggtgac ctcgtacggg ttgttcagca gcggcgaggt gcgccgggac
    24601 tccacctcga tctcccacac gcccggcgtc gggtcggcgt aggaccgcag gtcggggcgg
    24661 cactcgttgg ccgggttgtc gtagttcggg tagcacatgg tggtgctcga ctcgtcggcc
    24721 ggcgtgcccc acggggtgat ggcgatccac cgcgtctggc tgccctcggc gaggccgttc
    24781 atcgcgactt cgagcgtcct ggtgccctcg ggcacggtga cgaagtagga cgtcgagtcg
    24841 ttgcgctgcg cggtgccgga ctcggtgacc gagaagtcgg gcgccgagag ctcctgcggc
    24901 acgatgacgg tggccaggat ctggtggtcg atgccgtgcg tgcggcggtc gtcgacttcg
    24961 aggaccgcgc tgtgtgcgcc gagcgagcgc gggcgggcct ggagcgtg
//
