LOCUS       NZ_CP021121            24049 bp    DNA     linear   CON 31-JUL-2024
DEFINITION  Streptomyces marincola strain SCSIO 03032 chromosome, complete
            genome.
ACCESSION   NZ_CP021121
VERSION     NZ_CP021121.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces marincola
  ORGANISM  Streptomyces marincola
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6287975)
  AUTHORS   Ma,L., Zhu,Y., Zhang,W., Zhang,G., Tian,X., Zhang,S. and Zhang,C.
  TITLE     Complete genome sequence of Streptomyces sp. SCSIO 03032 revealed
            the diverse biosynthetic pathways for its bioactive secondary
            metabolites
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6287975)
  AUTHORS   Ma,L., Zhu,Y., Zhang,W., Zhang,G., Tian,X., Zhang,S. and Zhang,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2017) Key Laboratory of Tropical Marine
            Bio-resources and Ecology, South China Sea Institute of Oceanology,
            164 West Xingang Rd., Guangzhou, Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method :: Hierarchical Genome Assembly Process v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 165.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002128305.1-RS_2024_07_31
            Annotation Date                   :: 07/31/2024 06:55:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,513
            CDSs (total)                      :: 5,438
            Genes (coding)                    :: 5,343
            CDSs (with protein)               :: 5,343
            Genes (RNA)                       :: 75
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 95
            CDSs (without protein)            :: 95
            Pseudo Genes (ambiguous residues) :: 0 of 95
            Pseudo Genes (frameshifted)       :: 19 of 95
            Pseudo Genes (incomplete)         :: 88 of 95
            Pseudo Genes (internal stop)      :: 2 of 95
            Pseudo Genes (multiple problems)  :: 13 of 95
            CRISPR Arrays                     :: 12
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:29:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3202476
            Orig. end                         :: 3226525
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP021121.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Key Laboratory of Tropical
            Marine Bio-resources and Ecology.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24049
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="15"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24049
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24049
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14049](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14049)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            12..1781
                     /gene="aspS"
                     /locus_tag="CAG99_RS14105"
                     /old_locus_tag="CAG99_14095"
     CDS             12..1781
                     /EC_number="6.1.1.12"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0004812 - aminoacyl-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /GO_process="GO:0006418 - tRNA aminoacylation for protein
                     translation [Evidence IEA]"
                     /codon_start=1
                     /gene="aspS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019432117.1"
                     /locus_tag="CAG99_RS14105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_14095"
                     /product="aspartate--tRNA ligase"
                     /protein_id="WP_086159711.1"
                     /transl_table=11
                     /translation="MHRYRSHTCGELRSADIGKDVRLSGWLHNRRNLGGILFIDLRDHH
                     GIVQLVVHPEAPGAKAVDDTLGGLAKETVIRVDGRVVGRGADNVNAELATGDIEVEVTE
                     VEVLGAADQVPFTINSEDGVNEERRLEYRFLDLRRERMHRNIMLRSSVISAIRQKMTAQ
                     GFNELATPILSATSPEGARDFLVPSRLHPGTFYALPQAPQQFKQLLMVAGFDRYFQIAP
                     CFRDEDARADRSPGEFYQLDMEMSFVEQEDVFGVIERVMTELFTEFGGGRHVTSPFPRI
                     PYRDAMLKYGSDKPDLRARLELTDVSDVFAGSGFKAFADQHVRALAVPDTAQQPRRFFD
                     QLGEFAVEQGAKGLAWVRVGDDGQLTGPIAKFLTEENVAALRERLAAGPGTAVFFGAGA
                     FDEVSRIMGAVRVEAARRAGHFEENVFRFCWIVDFPMYERNEDTGAIEFSHNPFSMPQG
                     GLEALETKDPLDILAWQYDIVCNGIELSSGAIRNHEPDVMIKAFGIAGYSAEEVEREFG
                     GMLRAFRFGAPPHGGIAPGIDRIVMLLADEPNIRETIAFPLNGNAQDLLMGAPSPVDES
                     RLRELHLNVRRPS"
     gene            complement(1816..>1935)
                     /locus_tag="CAG99_RS27545"
                     /pseudo=""
     CDS             complement(1816..>1935)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005483781.1"
                     /locus_tag="CAG99_RS27545"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DUF4440 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="PATGQPRDLHARYTFGYERDRRSGTWLIVNHHSSVMPEG"
     gene            complement(2071..2586)
                     /locus_tag="CAG99_RS14110"
                     /old_locus_tag="CAG99_14100"
     CDS             complement(2071..2586)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012377658.1"
                     /locus_tag="CAG99_RS14110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_14100"
                     /product="tellurite resistance TerB family protein"
                     /protein_id="WP_086159712.1"
                     /transl_table=11
                     /translation="MAIWDRIKDSAKGRTGSGGSGGSGGGGQQLVSMFKNQLSSMKTEL
                     KSGAYRDASMAMCALVAAADGSVDHNERQHVESLIVSNDVLQNFPADSLRQRFNKHVDQ
                     LVGNFPAGRAAALQEIAKVQKKPMEARAVVQTGIVIAGADGYFAQAEQQVIREVCGALG
                     LSPSEFNM"
     misc_feature    2689..2704
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.23"
                     /tool="antismash"
     gene            complement(2782..5040)
                     /locus_tag="CAG99_RS14115"
                     /old_locus_tag="CAG99_14105"
     CDS             complement(2782..5040)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1037: heavy metal
                     translocating P-type ATPase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010043285.1"
                     /locus_tag="CAG99_RS14115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_14105"
                     /product="cation-translocating P-type ATPase"
                     /protein_id="WP_086159713.1"
                     /transl_table=11
                     /translation="MTATASDSAEVELAIGGMTCASCAARIEKKLNRMDGVTASVNYAT
                     EKAKVSYADGVTVADLVATVEATGYTAEEPRPAAAPAPEDGAEPPDDLAALRHRTAVTW
                     ALAVPVIVLAMVPAWQFDYWQWLSLTLAAPAVVWGGWQFHRAAWTNARHGAATMDTLVS
                     LGTLAALAWSVWALFFGHAGMPGMTHPFELTIERTDGAGAIYLEAAAGVTAFLLAGRYL
                     EARAKRRAGAALRALLDLGAKEVTVLRGGAERRVPVADLSPGDRFVVRPGEKIATDGVV
                     VGGSSAVDASMLTGESVPVEVAEGAQVTGATLNAGGRLVVEATRVGADTRLARMAKLVE
                     DAQNGKAAAQRLADRISAVFVPAVIAIAVATLGVWLAAGGGPTAAFTAAVAVLIIACPC
                     ALGLATPTALLVGTGRGAQLGILIKGPEVLENTRRADVVLLDKTGTVTTGRMALTGVTV
                     AAGEDEAEALRLAGALEHASEHPIARAVAAGAAEAAGTTAEELPAVRDFTNVPGLGVRG
                     LVEGRAVLAGRAGLLTEAGVTLPAELTEAAAGAEAAGRTAVLVAWDGRARAVLAVADAV
                     KGTSAEAVRRLRALGLTPVLLTGDNETVARAVAAEVGIDEVIAGVLPEEKVAVVRRLRD
                     EGRTVAMVGDGVNDAAALAAADLGLAMGTGTDAAIEAGDLTLVRGDLRAAADAIRLSRR
                     TLRTIKGNLWWAFGYNVAALPLAAAGLLNPMLAGAAMAFSSVSVVANSLRLRTFRAAS"
     misc_feature    5066..5081
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: medium, score: 25.7"
                     /tool="antismash"
     misc_feature    5066..5082
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 23.5"
                     /tool="antismash"
     misc_feature    5098..5113
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 21.3"
                     /tool="antismash"
     misc_feature    complement(5098..5114)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: medium, score: 27.32"
                     /tool="antismash"
     misc_feature    complement(5099..5114)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: medium, score: 25.7"
                     /tool="antismash"
     misc_feature    5125..5140
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: medium, score: 25.46"
                     /tool="antismash"
     misc_feature    5125..5141
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: medium, score: 26.96"
                     /tool="antismash"
     misc_feature    complement(5126..5141)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: medium, score: 27.98"
                     /tool="antismash"
     gene            5205..5984
                     /locus_tag="CAG99_RS14120"
                     /old_locus_tag="CAG99_14110"
     CDS             5205..5984
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091254.1"
                     /locus_tag="CAG99_RS14120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_14110"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_086159714.1"
                     /transl_table=11
                     /translation="MRRKNAALLVNRASLSHKIRYAARNPARIAPHARRVARDTWLRLR
                     HRDHVSYYRAVMASDTARDPDKAVGSASRARWRALGEMQFTYLTTHGLRPEHRMLDIGC
                     GNLRAGRWFIDYLGPGAYYGIDISPDILVSAKHTLVAYGLQDKVPHLTPTRDLTLDFLP
                     DAYFDVVHAHSVFSHSPLSVIDECLAHVGRVMAPGAFFDFTFDRTEGREHHVLREDFYY
                     RTETLVALAERHGLRARFEEDWEKLPHGQSRIRVTAS"
     misc_feature    6283..6296
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.86"
                     /tool="antismash"
     gene            6377..7408
                     /locus_tag="CAG99_RS14125"
                     /old_locus_tag="CAG99_14115"
     CDS             6377..7408
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019887988.1"
                     /locus_tag="CAG99_RS14125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_14115"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_086159715.1"
                     /transl_table=11
                     /translation="MSNGTGEPAIETRGLVKIFGDNRAVDGVDLTVPAGTVYGVLGPNG
                     AGKTTTVRMLATLLRPDAGEARVFGLDVFTQADAVRSRVSLTGQYASVDEDLTGTENLV
                     LLARLLGHRKPAARERAAALLDAFGLTEAADRQAKNYSGGMRRRLDIAASILNTPDLLF
                     LDEPTTGLDPRSRNQVWDIVRAVVAQGTTVLLTTQYLEEADRLAGRIAVIDKGRVIAEG
                     TPGHLKSSVGSGSIHLRLRDADRRPEARELLERVLGTTVHADADPLALTARLMQDGNAS
                     GPAELASHALAQLAAGGIVVDDFSLGQPSLDEVFLALTDGKAGRSATDTTATTKETKQE
                     AVA"
     gene            7405..8289
                     /locus_tag="CAG99_RS14130"
                     /old_locus_tag="CAG99_14120"
     CDS             7405..8289
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006347931.1"
                     /locus_tag="CAG99_RS14130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_14120"
                     /product="ABC transporter permease"
                     /protein_id="WP_086159716.1"
                     /transl_table=11
                     /translation="MTTATSADPAPKQSGKDGDEAEDTYTPTAETLGAVLAGVERPQRP
                     SPLSASLTFGWRAMLKIKHVPEQLFDVTVFPIMMTLMFTYLFGGALAGSTSEYLQFLLP
                     GIMVMSVVMTTMYTGVAVNTDIQKGVFDRFRTLPVWRPAAMVGYLLGDMLRYAMASVVI
                     LIVGLILGYRPEGGVLGVAAAILLLIVFSFAFSWIWTMFGLMLRSEKSVMGISMLVLMP
                     MTFLSNILVDPGTMPGWLQAFVDVSPVAHLVEAARGLMDGNVDTGEITWVLVASAVLVA
                     VFGTLTMRLYNRK"
     gene            complement(8360..8965)
                     /locus_tag="CAG99_RS14135"
                     /old_locus_tag="CAG99_14125"
     CDS             complement(8360..8965)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017236333.1"
                     /locus_tag="CAG99_RS14135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_14125"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_086159717.1"
                     /transl_table=11
                     /translation="MDRKSGRPLRADAERTVRAILEAAERVLSADPAATMEQIAEAAGV
                     ARTTVHRRFTSREALVEALAAWATRQFHEAVTSARTDSVPPLVALYQVTANVLRVKTSW
                     GFAMSRGTPEDPEAARVHADVLAQCDRLFLRAAEAGVLRQDVDLAWARRVYYALIHEAA
                     HDRRNAADDAADDVEALATRVVDTLLRGVGGRGAELGA"
     gene            9096..9887
                     /locus_tag="CAG99_RS14140"
                     /old_locus_tag="CAG99_14130"
     CDS             9096..9887
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020557346.1"
                     /locus_tag="CAG99_RS14140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_14130"
                     /product="oxidoreductase"
                     /protein_id="WP_086159718.1"
                     /transl_table=11
                     /translation="MDLHLAGKAAVVTGASRGIGLAVVSALVNEGMRVVAGARTTPPAL
                     VASGAICVPVDLSTAEGPALLIERAEAELGGLDLLVNNVGGGDSGEGQTGGLLTFTDEQ
                     WQQAYDLNFLSAVRTTRAALPHLVEDGGGSVVNVSSNAARSPHASPMPYTTAKAALTAF
                     GKAVAEEFGPQGVRVNTVSPGAVRTSLWEDPGRYGVALAEKMGMEHAQLLDRIPAATGM
                     LTGRFIRPDEVADLVAYLASPAAASIVGADYIIDGGALKTA"
     gene            complement(10001..11197)
                     /locus_tag="CAG99_RS14145"
                     /old_locus_tag="CAG99_14135"
     CDS             complement(10001..11197)
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="CAG99_RS14145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_14135"
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_086159719.1"
                     /sec_met_domain="LANC_like (E-value: 6.9e-29, bitscore:
                     99.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDEHRALSATKSQELALALGPTRAVATAVSARAAHTLCYGLAGT
                     ALLHACLGDATTAVRHWNAASQVLGDAPADGIHTGPGALAASLIIGTAHLPERGPHHAL
                     APRATSWLSARAQALAQLQRTSPGSWAPWAVYDAIKGLSGIGRILLVSHATGHRAEATP
                     GLHAALTTLIRMILTDQGTRPGWWLPAHAHPPSVPVPPSGAATTGMAHGIAGPLAFLAL
                     AHLAGHIAPGQHDAIAGAAHWLLTWADPGPSWPPHVSGADLDAGPTPPPGVIPGRRTAW
                     CYGTPGIATALTHAGHALGEPAFLRTATAALDHLATDVSTWDTEGPGLCHGAAGVLASA
                     RHGGSRLAARARDTVLSLPSAAPGLLGGRAGTALALADDAGLLARQRAAPWESVLLIS"
     gene            complement(11194..14049)
                     /locus_tag="CAG99_RS14150"
                     /old_locus_tag="CAG99_14140"
     CDS             complement(11194..14049)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="CAG99_RS14150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_14140"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_086159720.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 5.8e-121,
                     bitscore: 403.0, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.5e-08,
                     bitscore: 32.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 9.6e-28, bitscore:
                     95.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRRLFAAHPVAMARVPLRPDQGVGDEADGLLIEGVLFAGSIDMS
                     KARRDARTRATLRAYDLRSRSRTTPHGVFAAVAPAALTARATTLRLGRAHRAITMPSAR
                     WLTALADQLLDEHPELLHTLTLTTSNLVTSRGDRFVAERPTERGAETGSVRNTEVSRWL
                     LRACADGAPAADLLADLSKRHPDVAPATIARAVLNMVKAGALLDDLLPDDLRADPLQHL
                     LGRLPAQSPSAHTLRRLAAVLREADAHTPGSPRRRPLLSAARDLANSLRPTPRPLIADT
                     LADAQISLPWSVGDSAALAASVLWRIGHRTPPLGDYHRRFLARYGRHRLVPLLEALDPV
                     AGLGPPTVHDALGTDEGLSPSRMTALASLLAGALSTGTPEIALQDHHLAQLANPSPLPP
                     PRTAEIHIQLLNSESEAPDIAVVPGTGSQDAGAAPGRWTRWLPELTPDEHAGNGTGPMV
                     AEIACRARTAATGTLNAETGTAPWRIPLGVPRRPEDLIPEELALVVSGTHLALWSTRHD
                     RPVTPVLRSRVAPRLLPPAARALHLLGHANTRPWHPWSWGPLSAFPFTPRVRYHGILLC
                     PARWQVPAELATAAGNRAAFASTLEVWQRTVHPALPGTVVVAENDRRLPLDLHDPDDRE
                     LLRRSVHRGTRSLHEPLGSPEALRVLPGPDRERHHLELVVALTRRDSPPSSRPSPRRAI
                     RGAHAGRHLPGGSWLSAALPGPSDLHDTTLTELSPLLERLTTAPDIDRWFWLRYTTPAL
                     GPHLRLRVHGDPTALNSRVQPQLATATARLRRQGLCSGLHLEPYEQEIERYGGEQAMAS
                     AECFFHADSALALRALRLTDSQRLLLAAASSAEIAGALAPEQPRRALAPGRLTRDQRRH
                     RDTLRAITRGGAAALIPPFLATVHAQRRRALLAYRDVLAPAFAASCASDLIHMHNNRLL
                     STDPSHERLARTLAADLLHRP"
     aSDomain        complement(13417..13671)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CAG99_RS14150_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.30E-10"
                     /identifier="RREFam001.1"
                     /label="CAG99_RS14150"
                     /locus_tag="CAG99_RS14150"
                     /protein_end="211"
                     /protein_start="126"
                     /score="32.8"
                     /tool="antismash"
                     /translation="TTSNLVTSRGDRFVAERPTERGAETGSVRNTEVSRWLLRACADGA
                     PAADLLADLSKRHPDVAPATIARAVLNMVKAGALLDDLLP"
     gene            complement(14144..14329)
                     /locus_tag="CAG99_RS14155"
                     /old_locus_tag="CAG99_14145"
     CDS             complement(14144..14329)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018840603.1"
                     /locus_tag="CAG99_RS14155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_14145"
                     /product="hypothetical protein"
                     /protein_id="WP_086159721.1"
                     /transl_table=11
                     /translation="MTPSSAPSPAPAPELADAFDLDLRQQPVSGLHVWLSGGEEEGDTT
                     GDGCGESPPQGPTTGC"
     misc_feature    complement(14335..14352)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.29"
                     /tool="antismash"
     gene            complement(14409..15632)
                     /gene="fxlM"
                     /locus_tag="CAG99_RS14160"
                     /old_locus_tag="CAG99_14150"
     CDS             complement(14409..15632)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="CAG99_RS14160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_14150"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_086159722.1"
                     /sec_met_domain="PCMT (E-value: 4.5e-34, bitscore: 116.3,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEHRMTAEAAADAGELRERMVRELVRSGAIVHPAVEAAFRAVPR
                     HRFAPHVPAAEVYGAPEAIFTKRTDDGRVVSSVSAPWLHARMLEAARLAPGMRVLEIGS
                     GGCNAALLAELVGPAGVVTSLDIDPDITGRARRLLDDAGYQRVQVRTGDGALPVPDAPA
                     GGWDRIIVTAGSADLPETWLDQLSGSGRLVVPLRFRGLSRTFAFAWRGDQLRSDSTIVS
                     GFLAMRGKSADAPRIVRLADEDVRLTVDERQPCDESALRAAFSSVGHEVWTGVRLTGSE
                     GVLPRLDVWLAGVVAPYGRLRASRAAAERGLVGWVLGTGAAAIWTDSSLAYLALRSAPE
                     HANQFELGVVAHGPDRKDLGLAFADEVIRWNTTARHQGEPEVRVHRLDDLAPPGVVIEK
                     PSVRLTIG"
     gene            complement(16062..16310)
                     /locus_tag="CAG99_RS14165"
                     /old_locus_tag="CAG99_14155"
     CDS             complement(16062..16310)
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]"
                     /GO_function="GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]"
                     /GO_process="GO:0051290 - protein heterotetramerization
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019433124.1"
                     /locus_tag="CAG99_RS14165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_14155"
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_255308100.1"
                     /transl_table=11
                     /translation="MSRRYRLQYSNEARDALRKMSSPRRRRFEAAVAEIAVDPYAHGQA
                     LGGNRDRRQATLAGAITVYWVSTGVLTVSVVTVIHSD"
     gene            complement(16307..16600)
                     /locus_tag="CAG99_RS14170"
                     /old_locus_tag="CAG99_14160"
     CDS             complement(16307..16600)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CAG99_RS14170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CAG99_14160"
                     /product="hypothetical protein"
                     /protein_id="WP_086159723.1"
                     /transl_table=11
                     /translation="MGETTGGPVGPVWRTWLDGEEIELPASINGIRAALPPERREQFDE
                     AVGAAAAGELELLLGHWAQETRPDLRAAQEAVFRRLEAGDSTGFIAAEDLDA"
     gene            complement(16765..17214)
                     /locus_tag="CAG99_RS14175"
                     /old_locus_tag="CAG99_14165"
     CDS             complement(16765..17214)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018852426.1"
                     /locus_tag="CAG99_RS14175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_14165"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_086159724.1"
                     /transl_table=11
                     /translation="MAVRMETPVSPDVMTAVQHLIKAVHAGGVDPLVLELVHLRASQIN
                     GCSTCVHAGVASAKRHGETEERLHQVAAWRETPFFSEPERAALALAEAATRIQDGAPGV
                     TDAVWEAASAHFDEKQLASLTLHIAMTNFFNRVNHTIREQAGKTW"
     gene            17309..18187
                     /locus_tag="CAG99_RS14180"
                     /old_locus_tag="CAG99_14170"
     CDS             17309..18187
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018852427.1"
                     /locus_tag="CAG99_RS14180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_14170"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_086159725.1"
                     /transl_table=11
                     /translation="MADPHPADSVAEAFEAQRDRLRAIAHRVLGSHADAEDVIQETWLR
                     LSRQDPATIRNLPGWLTTVVGRISLDVLRSRRAHPEASLDARLPDLVVTVDDGPGPEDD
                     VALADSVGLALLVVVQSLGPSERMAFVLHDLFAVPFHDIAQILGKSTDATKMLASRARR
                     KVRATEQPTASGRERREVVDAFLAAAREGDFDGLLRVLDPDVRLTAETAGGMVVSLGAT
                     EVATGARLAAGAAARGRAVLVNGLPGWLAWHADGSPLSVLAFSVTDGRITAIAAVSDPA
                     RLAAMDLPEPR"
     misc_feature    complement(17310..17324)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.25"
                     /tool="antismash"
     gene            complement(18260..18481)
                     /locus_tag="CAG99_RS14185"
                     /old_locus_tag="CAG99_14175"
     CDS             complement(18260..18481)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138944.1"
                     /locus_tag="CAG99_RS14185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_14175"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_086159726.1"
                     /transl_table=11
                     /translation="MNARTDDLYAVDLTNATWRRSSRSNGAAQCVEAADIPGGGIAIRD
                     SKDPHRTPLRWTTPQWDAFRQHIVDGTL"
     gene            complement(18478..19353)
                     /locus_tag="CAG99_RS14190"
                     /old_locus_tag="CAG99_14180"
     CDS             complement(18478..19353)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007268907.1"
                     /locus_tag="CAG99_RS14190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_14180"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_086159727.1"
                     /transl_table=11
                     /translation="MPNVRAIPTLRRRRLGGTLRRYRHEAGVTLVTAATAMGWDDSKLS
                     RIETAVARLLPQDVAKLLSQYGVTDPQVIAALEGLAKDAGKQGWWQAYGDVVALNYKDY
                     LTLETDAESVHIYTPGLVPGLLQTGPYAREIIAGISTTHTSEEVAALAEIRKMRQAILT
                     TRPEGRPLKLWAVVHEAGLHQRFAGQPFLMRQQLKHLLDMTELPNVTIQVMPLIATPNP
                     GMLGLFEIVRFPHPWATVVNLENIQGGYFVEGTEDVKVFESAFERVVAAALSVDDSRQL
                     IRTLIERNRK"
     misc_feature    complement(19382..19395)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 17.97"
                     /tool="antismash"
     misc_feature    19551..19566
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.75"
                     /tool="antismash"
     gene            19582..19863
                     /locus_tag="CAG99_RS14195"
                     /old_locus_tag="CAG99_14185"
     CDS             19582..19863
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CAG99_RS14195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CAG99_14185"
                     /product="hypothetical protein"
                     /protein_id="WP_086159728.1"
                     /transl_table=11
                     /translation="MTTICRTFPPTPPPAWLVPGIRVRDAASRGLGVVLLLQDARREVS
                     TRWISRPVRALLRADCWGGPLWWAPAAGLSPADECVRCLGHCPLPALA"
     gene            19917..20543
                     /locus_tag="CAG99_RS14200"
                     /old_locus_tag="CAG99_14190"
     CDS             19917..20543
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CAG99_RS14200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CAG99_14190"
                     /product="hypothetical protein"
                     /protein_id="WP_086159729.1"
                     /transl_table=11
                     /translation="MTWGPHQLPVPHAAAWSAERTAVAGALTVRADGAGLAYRDERPGD
                     RDGQGVLWARIGQAQGQGRPNFRALHSGRQRGAMLDKLCQVCGGQASRTGRGWLFLLQR
                     PAPPEARDWPEGLLCTKPPVCRPCAALAMRHCPHLSDPVVVRSRKPRTWGVFGGFFTPA
                     PDGGLAPHADSALPYGDARAPWFLASQLVVELTRCTVESAPRPAR"
     gene            complement(20560..23712)
                     /locus_tag="CAG99_RS14205"
                     /old_locus_tag="CAG99_14195"
     CDS             complement(20560..23712)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018513976.1"
                     /locus_tag="CAG99_RS14205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_14195"
                     /product="AAA family ATPase"
                     /protein_id="WP_255308101.1"
                     /transl_table=11
                     /translation="MFDTMIGREHAAGVLRAEIARTTTSHGGLVLVTGEAGIGKTTLVT
                     GAAEEARARGALVLGGSCWHAENAPGHWPWTQVVRGLRRAATGEEWAAAEHAAGADLAG
                     WTTGGDGGRAESFALHDAVTTALVTVSQRRPVALVLEDLHWADTGSLRLLDFAARHTWF
                     ERLLLICTYRDTEVAAEDHPLHALLMPLVSRATTLALTGLAPHEVGALMARTTGGAPDA
                     ALAARVHRHTGGNPFFVEQTARLWHGGEGTGVPPGVREAVRRRLGLLPEQVVALLTRAA
                     VLGRAFHRRVLAATAPGTGTEVDRLLAHAEAARLVTRNGPDRFAFAHDLMRETLHESLD
                     GAERRRRHAAVVRALAGAPELSDLVPPADLARHARLAGDELDPAHAVELLRSAAEDAKG
                     RMAFDESLGHMRDAFHLAEGLGPRRHVLAGLDLATELRHTGDSAGAAAAFARCADEARA
                     LDDAELLARVALAQYDSHGATLRSGVDRSHADLLHDAHRRLVGTPAGRPPPAGDDPATL
                     ERLARELSIRSAVLARRAGDEDALAFSLWSLHDAIWGPGTAAERQALTTELAGLARRNG
                     DGDLGHFSMALGWVTLLERGDPAYLHQLDAFLASAERSGRPRYRLSATVDRAIVAVLHG
                     RFTEAEDLHAELVELTRREGNAQHMGAFRDHMRRCLLLAQGRFPELAEANAARSAKRHA
                     HPELVAGIAAAEQGDAAAALRQYETSRSVPRPRYAEALWLRFQAQAAALSGDADLIARA
                     RAELAPLTGQWAVGLFGFDIGGPWALWSALLDQAEERWDAAVAGYTEAATSADRLLARP
                     WAVRARLGLGRSLLGRGRPGDADTARATLREAEEEAARLGLRHIEEQAATALAAPHVAR
                     RTDEFRFDGSVWTLRYAGRTVHLPDAKGLRDLWRLIGQPGQDIAAGRLLDPAGEAPLYG
                     GDPVLDDEAKARYRRHLEQLDDEVDRAAARGDAARAADLDRERAALLTELRTAAGLGGR
                     TRRLGDEAERARKTVTARIRDTLRRLDTRHPELAAHLRASVSTGTMCAYRPPRDEAPRF
                     RL"
     gene            complement(23737..24015)
                     /locus_tag="CAG99_RS14210"
                     /old_locus_tag="CAG99_14200"
     CDS             complement(23737..24015)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003985866.1"
                     /locus_tag="CAG99_RS14210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_14200"
                     /product="DUF2277 domain-containing protein"
                     /protein_id="WP_086159730.1"
                     /transl_table=11
                     /translation="MCRSIKTLRPPATPEVTDDDIRAAALQYVRKVSGFRSPAAHNREV
                     FDAAVAEVAEATRHLLDHLRVRGTTRTAPNGTASNGERDTGSGPLPG"
ORIGIN
        1 ttggatgaac gatgcatcgg taccggtccc acacctgcgg cgagctgcgc tccgcggaca
       61 tcggcaagga cgtccggctg tccgggtggc tgcacaatcg ccggaacctg ggcggcatcc
      121 tgttcatcga cctgcgcgac caccacggca tcgtgcagct cgtcgtgcac cccgaggccc
      181 cgggcgccaa ggccgtggac gacacgctcg gcggcctggc caaggagacg gtcatccgcg
      241 tcgacggccg cgtggtcggc cgcggcgccg acaacgtcaa cgccgagctg gccaccggtg
      301 acatcgaggt cgaggtgacc gaggtcgagg tgctcggtgc cgccgaccag gtgccgttca
      361 cgatcaacag cgaggacggc gtcaacgagg aacgccggct cgaataccgc ttcctcgacc
      421 tgcgccgcga gcgcatgcac cgcaacatca tgctgcgctc ctccgtgatc tccgcgatcc
      481 ggcagaagat gaccgcccag ggcttcaacg agctggccac gccgatcctt tcggccacct
      541 cgcccgaggg cgcgcgcgac ttcctggtgc cctcgcggct gcaccccggc accttctacg
      601 cgctgcccca ggcgccccag cagttcaagc agctgctgat ggtcgcgggc ttcgaccggt
      661 acttccagat cgcgccgtgc ttccgcgacg aggacgcgcg ggccgaccgc tcgcccggcg
      721 agttctacca gctcgacatg gagatgagct tcgtcgagca ggaggacgtg ttcggcgtca
      781 tcgagcgcgt gatgaccgag ctgttcacgg agttcggcgg cgggcggcac gtcacctcgc
      841 cgttcccgcg catcccctac cgcgatgcga tgctgaagta cggctcggac aagcccgacc
      901 tgcgcgcgcg cctggagctg acggacgtct ccgacgtctt cgccggctcg ggcttcaagg
      961 cgttcgcgga ccagcacgtg cgcgcgctcg cggtccccga cacggcgcag cagccgcgcc
     1021 ggttcttcga ccagctcggc gagttcgccg tggagcaggg cgccaagggc ctggcctggg
     1081 tgcgggtcgg tgacgacggg cagctgaccg gccccatcgc gaagttcctc accgaggaga
     1141 acgtggcggc gctgcgcgag cggctggccg ccggtcccgg cacggccgtg ttcttcggcg
     1201 cgggcgcgtt cgacgaggtg tccaggatca tgggcgcggt gcgggtcgag gccgccaggc
     1261 gcgccggcca cttcgaggag aacgtcttcc gcttctgctg gatcgtggac ttccccatgt
     1321 acgagcggaa cgaggacacc ggcgcgatcg agttctcgca caacccgttc tccatgccgc
     1381 agggcggcct cgaagcgctg gagaccaagg acccgctgga catccttgcc tggcagtacg
     1441 acatcgtgtg caacggcatc gagctgtcct ccggcgccat caggaaccac gagcccgacg
     1501 tgatgatcaa ggcgttcggc atcgccgggt acagcgccga ggaggtcgag cgcgagttcg
     1561 gcggcatgct gcgcgcgttc cgcttcggcg ccccgccgca cggcgggatc gccccgggca
     1621 tcgaccgcat cgtgatgctg ctcgccgacg agccgaacat ccgcgagacg atcgccttcc
     1681 cgctcaacgg caacgcgcag gacctgctga tgggcgcgcc gagcccggtg gacgagtccc
     1741 ggctgcggga gctgcacctg aacgtgcggc ggccgtcctg accgccgcac gtccgcgccg
     1801 cgcggccggg gggcgtcagc cctccggcat caccgacgag tggtggttga cgatcagcca
     1861 cgtgccgctg cgccggtcgc gttcgtagcc gaacgtgtag cgggcgtgca ggtcgcgggg
     1921 ttgacccgtg gccggaaacg gcaaaggcag ccccggacgc cggcaacgga accctcaact
     1981 ccgttgtccg gggctgctgt cggctccgtg tcgcacgtcg tgcgagcccg gtgcgcgaga
     2041 gggcgcgtgc gcgggcgcac gcgggcgtcc tcacatgttg aactcgctgg gggagagccc
     2101 gagcgcgccg cacacctccc ggatgacctg ctgctctgcc tgcgcgaagt agccgtcggc
     2161 gcccgcgatg acgatgccgg tctggacgac ggcccgcgcc tccatcggct tcttctgcac
     2221 cttggcgatc tcctggagcg ccgcggccct gccggccggg aagttgccga cgagctggtc
     2281 cacgtgcttg ttgaagcgct gccgcaacga gtcggccggg aagttctgaa ggacgtcgtt
     2341 gctgacgatc agcgactcca cgtgctgccg ctcgttgtgg tcgaccgagc cgtcggcggc
     2401 ggcgaccagc gcgcacatcg ccatgctggc gtcccggtag gctccgctct tcagctccgt
     2461 cttcatcgag gacagctggt tcttgaacat gctcaccagc tgctggccgc cgcccccgct
     2521 ccccccgctg ccgccggagc cggtccgccc cttcgccgag tccttgatcc ggtcccagat
     2581 ggccatcgcc tgtcacctcg gttgtcgtca gtcagtaccc cgtcaacgta tccggtcggc
     2641 ggcccggttc cccccccgat cgccgggacg agggggcgca cgcggggatt cacgcctcgt
     2701 tcaccccccg gttcacacgc gtgtcccggc cggcgcgccc accccgcgcc cgccccctcg
     2761 tcccgggcgc ggggtgggcg ctcaggacgc ggcgcggaac gtgcgcagcc gcaggctgtt
     2821 ggcgaccacg gacaccgagg agaacgccat cgccgcaccc gcgagcatgg ggttgagcag
     2881 accggccgcc gcgagcggca gcgcggcgac gttgtagccg aacgcccacc acaggttgcc
     2941 cttgatcgtc cgcagcgtcc ggcgcgagag ccgaatcgcg tcggccgcgg cccgcaggtc
     3001 accgcgcacc agcgtgaggt cccccgcctc gatcgccgcg tccgtccccg tgcccatcgc
     3061 gaggccgagg tcggcggcgg cgagcgccgc cgcgtcgttg acgccgtcgc ccaccatggc
     3121 cacggtgcgg ccctcgtccc gcagccgccg cacgacggcc accttctcct cgggcagcac
     3181 cccggcgatc acctcgtcga tgccgacctc ggcggcgacg gcgcgcgcca ccgtctcgtt
     3241 gtccccggtc agcaggaccg gcgtcaggcc gagcgcccgc agccgccgca ccgcctcggc
     3301 gcttgtgccc ttgaccgcgt cggccacggc gagcacggcg cgcgcccggc cgtcccacgc
     3361 gacgagcacg gccgtgcggc ccgcggcctc ggccccggcc gccgcctcgg tcagctcggc
     3421 gggcagcgtg acgccggcct cggtcagcag cccggcccgg cccgcgagca cggcgcggcc
     3481 ctcgacgagg ccccgcacgc cgagcccggg gacgttggtg aagtcccgca ccgcgggcag
     3541 ttcttccgcc gtcgtgcccg cggcctcggc cgcgcccgcg gcgacggccc gcgcgatcgg
     3601 gtgctccgag gcgtgttcga gggcgccggc cagccgcagc gcctccgcct cgtcctcgcc
     3661 cgccgccacg gtgacgccgg tcagcgccat ccgtcccgtg gtgacggtgc cggtcttgtc
     3721 gagcagcacg acatcggccc gccgcgtgtt ctccagcacc tcgggcccct tgatcaggat
     3781 gccgagctgc gcgccgcgcc cggtgcccac cagcagcgcc gtgggcgtgg cgagcccgag
     3841 ggcgcacggg cacgcgatga tcagcacggc cacggccgcg gtgaacgcgg cggtcggccc
     3901 gccccccgcg gccagccaca caccgagcgt ggccacggcg atggcgatga cggccggcac
     3961 gaacacggcc gagatccggt ccgccaggcg ctgcgccgcg gccttcccgt tctgcgcgtc
     4021 ctccacgagc ttcgccatcc gcgccagccg cgtgtccgcg ccgacccgcg tggcctcgac
     4081 gaccagccgg ccgcccgcgt tgagcgtggc gccggtgacc tgggcgccct ccgcgacctc
     4141 gacgggcacg gactcgccgg tcagcatgga ggcgtcgacg gccgagctgc ccccgacgac
     4201 gacgccgtcg gtcgcgatct tctcgcccgg ccgcaccacg aaccggtcgc ccgggctcag
     4261 gtccgcgacc ggcacgcgcc gctcggcgcc gccgcgcagc acggtgacct ccttggcgcc
     4321 gaggtcgagc agggcgcgca gcgcggcgcc cgcgcggcgc ttggcgcgcg cctccaggta
     4381 gcggcccgcg agcaggaacg cggtgacgcc cgcggcggcc tccaggtaga tcgcgcccgc
     4441 gccgtccgtg cgttcgatgg tcagctcgaa cgggtgggtc atgccgggca tgcccgcgtg
     4501 cccgaagaac agcgcccaca ccgaccaggc gagcgcggcc agcgtgccga gggacaccag
     4561 cgtgtccatg gtcgcggcgc cgtgccgcgc gttcgtccac gcggcgcggt ggaactgcca
     4621 gccgccccac accacggcgg gcgcggccag ggtcagcgac agccactgcc agtagtcgaa
     4681 ctgccaggcg ggcaccatgg ccaggacgat caccggaacg gccagggccc aggtcaccgc
     4741 cgtgcggtgg cgcagggccg ccaggtcgtc cggcggctcc gcgccgtcct cgggcgcggg
     4801 cgcggcggcc gggcgcggct cctcggcggt gtagccggtg gcctcgacgg tggcgacgag
     4861 gtcggcgacg gtgacgccgt cggcgtagga gaccttcgcc ttctcggtgg cgtagttgac
     4921 ggaggcggtg acgccgtcca tccggttgag cttcttctcg atccgggcgg cgcaggacgc
     4981 gcaggtcatg ccgccgatgg ccagctcgac ctcggcgctg tcggatgcgg tggctgtcat
     5041 gggggcggct cctcggtggc caacgatacc cgtgggaggt atgtgttcgc ctcctgtgta
     5101 ccccaccggg gtatagcgag gcaagtaccc ccagggggta tgcgccgcgc cccgtgtcgc
     5161 gcgccttccg gggggaaagc gccatctgca ccaagctgcc ccgtatgcga aggaagaacg
     5221 ccgccctgct cgtgaaccgg gccagcctct cccacaagat ccgttacgcg gcgcgcaatc
     5281 cggcgcgcat cgcgccgcac gcgcggcgcg tggcccgcga cacctggctg cggctgcggc
     5341 accgcgacca cgtgtcctac taccgcgcgg tgatggcatc cgacaccgcc cgcgaccccg
     5401 acaaggccgt gggcagcgcg agccgggcgc gctggcgggc gctgggcgag atgcagttca
     5461 cctacctgac cacgcacggt ctcaggccgg agcaccgcat gctcgacatc ggctgcggca
     5521 acctgcgcgc gggccggtgg ttcatcgact acctggggcc cggcgcctac tacgggatcg
     5581 acatctcgcc ggacatcctc gtcagcgcca agcacaccct ggtcgcctac ggcctccagg
     5641 acaaggtgcc gcacctgacg ccgacccgtg acctcaccct cgacttcctg cccgacgcgt
     5701 atttcgacgt cgtgcacgcg cacagcgtgt tctcgcactc gcccctgtcc gtgatcgacg
     5761 aatgcctcgc gcacgtcggc cgcgtcatgg cgccgggcgc gttcttcgac ttcaccttcg
     5821 accgcaccga gggccgcgag caccacgtgc tgcgcgagga tttctactac cggacggaaa
     5881 cgctcgtcgc gctcgcggaa cggcacggac tgcgcgccag gttcgaggag gactgggaga
     5941 agctgccgca cggccagtcc agaatccgcg tcaccgcgtc ctgacccggg ccgcccccgc
     6001 gctcccccgc cgggccgccg cgagatctcc tctcgcggcg gcccggcggc gtctcgcgcc
     6061 ctcctggtgt gcggagaaaa ggagcggcgt cgcgggaggt gtccgtttac catgggccct
     6121 tccgcctccc gccgggggcc cgccggccgc gcccgcccgc tcccgggggg cacgggccgt
     6181 ccgcgcgacg gagcccggcc gcccgccggg gacggattcg ggagaacccg gtgagaaaag
     6241 tctcgtcggc ggcgatgaga aagcggctcc gcccgagtcc aacgaacata cgaacgaatg
     6301 ccacgtggct cacgcctgcg gctcgtgcgg ccacgaaggc cggcaaaacc acacggacca
     6361 cacggaaagg acagtgatga gtaacggcac gggcgagccc gcgatcgaga cccgcggact
     6421 cgtcaagata ttcggcgaca accgggcggt cgacggcgtc gatctcacgg tgcctgcggg
     6481 caccgtctac ggcgtcctcg gccccaacgg cgcgggcaag accaccaccg tccgcatgct
     6541 ggcgaccctc ctgcggccgg acgcgggcga ggccagggtc ttcggtctcg acgtgttcac
     6601 ccaggccgac gccgtccgca gccgcgtcag cctcaccggg cagtacgcct cggtcgacga
     6661 ggacctgacc ggcacggaga acctggtgct cctcgcgcgc ctcctcggcc accgcaagcc
     6721 ggccgcgcgg gaacgggccg ccgcgctgct cgacgcgttc gggctgaccg aggccgccga
     6781 ccggcaggcg aagaactact cgggcggcat gcgccgccgc ctcgacatcg ccgcgagcat
     6841 cctcaacacc cccgacctgc tgttcctcga cgagcccacc acgggcctcg acccgcgcag
     6901 ccgcaaccag gtctgggaca tcgtgcgcgc cgtcgtcgcc cagggcacga ccgtgctgct
     6961 caccacgcag tacctggagg aggccgaccg gctcgccggc cggatcgccg tcatcgacaa
     7021 ggggcgcgtg atcgccgagg gcacccccgg ccacctgaag tcgtccgtcg gctccggctc
     7081 gatccacctc aggctgcgcg acgccgaccg ccgccccgag gcgcgcgagc tgctggaacg
     7141 cgtcctcggc accaccgttc acgccgacgc cgacccgctg gccctcaccg cgcggctcat
     7201 gcaggacggc aacgcctcgg gccccgccga gctggcctcg cacgccctgg cccagctcgc
     7261 cgcgggcggc atcgtcgtcg acgacttctc tctcggccag ccgagcctcg acgaggtctt
     7321 cctcgccctg accgacggca aggccggccg gtccgccacc gacaccaccg ccacgacgaa
     7381 ggaaacgaag caggaggccg tggcatgacc accgcgacca gtgccgatcc ggcacccaag
     7441 cagagcggca aggacggcga cgaggcggag gacacctaca cgcccaccgc cgagacgctg
     7501 ggcgcggtgc tcgccggcgt ggaacgcccg cagcggccca gcccgctgtc ggcgtcgctc
     7561 acgttcggct ggcgcgcgat gctgaagatc aagcacgtgc ccgagcagct gttcgacgtg
     7621 accgttttcc cgatcatgat gacgctcatg ttcacgtacc tgttcggggg tgcgctcgcc
     7681 gggtccacga gcgagtacct tcagttcctg ctgcccggga tcatggtcat gagcgtggtg
     7741 atgaccacca tgtacaccgg cgtcgcggtc aacaccgaca tccagaaggg cgtcttcgac
     7801 cgtttcagga ccctcccggt ctggcgcccc gccgcgatgg tcggctacct cctcggcgac
     7861 atgctcaggt acgcgatggc gtccgtcgtg atcctgatcg tcggcctgat cctcggctac
     7921 cggcccgagg gcggcgtgct cggcgtggcg gcggcgatcc tgctgctcat cgtcttctcg
     7981 ttcgcgttct cgtggatctg gacgatgttc gggctcatgc tgcgctccga gaagtccgtg
     8041 atgggcatca gcatgctcgt gctgatgccg atgaccttcc tcagcaacat cctggtcgac
     8101 ccgggcacga tgcccggctg gctccaggcg ttcgtcgacg tcagccccgt cgcccacctc
     8161 gtcgaggccg cgcgcggcct gatggacggc aacgtcgaca ccggcgagat cacctgggtg
     8221 ctggtggcga gcgcggtgct tgtcgccgtg ttcggcaccc tgacgatgcg gctgtacaac
     8281 cgcaagtgag gtcggacgac ggcccgtcgc cccgcgcgtc gcgcgagggt gacgggccgt
     8341 tccgctgtcc gcgacccggt caggcgccga gttcggcgcc gcgcccgccg accccgcgca
     8401 gcagcgtgtc gaccacgcgg gtcgccagcg cctccacgtc atcggccgcg tcatcggccg
     8461 cgttcctgcg gtcgtgggcg gcctcgtgga tcagcgcgta gtagacgcgg cgggcccatg
     8521 cgaggtcgac gtcctggcgc agcacgccgg cctcggcggc gcgcaggaac aggcggtcgc
     8581 actgggcgag cacatcggcg tgcacccgtg ccgcctccgg gtcctccggc gttcccctgc
     8641 tcatcgcgaa gccccaactg gtcttcacgc gaagcacgtt ggcggtcacc tggtagagcg
     8701 ccacgagcgg cggaacgctg tcggtgcggg cgctggtcac ggcctcgtgg aactgccgcg
     8761 tggcccaggc cgccagcgcc tcgaccagcg cctcgcggct ggtgaatcgc cggtgcacgg
     8821 tcgtccgcgc gacaccggcc gcctccgcga tctgctccat ggtggccgcc ggatcggcgc
     8881 tgagcacgcg ttccgcggct tcgaggatgg cccgcacggt ccgttccgcg tccgcgcgca
     8941 acggccgccc gctcttccgg tccatgaggc tccctcccat tgaggcaccg gaaacactac
     9001 gccacggtcg caccccatcc catacttgca acatcgatgt cgcagcttct atggttctcg
     9061 cgtcgaagct gacgcaattt cgcgaggagt gctccatgga tctgcacctg gcaggcaagg
     9121 ccgccgtcgt gaccggcgcg agccggggga tcggcctggc cgtcgtttcc gcgctggtga
     9181 acgaaggaat gcgggtggtg gccggggcgc gcacgacccc gccggcactg gtggcctccg
     9241 gcgcgatctg cgtgcccgtc gacctctcga cggccgaggg acccgccctg ctcatcgagc
     9301 gggcagaagc cgaactcggc ggcctcgacc tcctggtcaa caacgtcggc ggcggcgact
     9361 ccggcgaagg gcagacgggc ggcctgctca ccttcaccga cgagcagtgg cagcaggcgt
     9421 acgacctgaa cttcctctcc gccgtccgca ccacccgggc cgcgctgccc cacctcgtcg
     9481 aggacggggg cgggtccgtc gtcaacgtct cctccaacgc cgccaggagc ccgcacgcca
     9541 gtcccatgcc ctacaccacc gccaaggccg cgctgaccgc gttcggcaag gcggtcgcgg
     9601 aggagttcgg cccccagggc gtgcgggtca acaccgtgtc gcccggcgcg gtccgcacct
     9661 ccctgtggga ggaccccggc cggtacggcg tggcgctggc cgagaagatg ggcatggagc
     9721 acgcgcagct gctcgaccga atcccggccg ccaccggcat gctcaccggc cggttcatac
     9781 gccccgacga ggtcgccgac ctcgtcgcct acctcgcctc ccccgccgcc gccagcatcg
     9841 tcggcgccga ctacatcatc gacggcggcg cgttgaagac cgcctgaccc acccgccgac
     9901 cccagaaccc cccgccccgg caggcccgtt cccccgccga ggtctgcggg ggaacgggcc
     9961 gtgggccggt gggggcgcgc catcttcctc ggcggagagg tcaggagatg agcaggacgc
    10021 tctcccacgg agcggcccgt tggcgggcga gtagtccggc gtcatcggcc agggcgaggg
    10081 cggtaccggc acggccgccg aggaggcccg gcgcggcgga gggcagagac aggacggtgt
    10141 cgcgggcacg ggcggcgagc cgggaaccgc cgtggcgggc gctggcgagt acgcctgccg
    10201 cgccatggca aagaccaggg ccttcggtgt cccaggtgga gacgtcggtc gcgaggtggt
    10261 cgagggccgc tgtggcggtg cggaggaaag cgggttcacc gagagcgtgg ccggcgtgcg
    10321 tgagggcggt ggcgatcccc ggggtgccat agcaccaggc ggttctgcgg ccggggatga
    10381 cgccgggagg cggggtgggc ccggcgtcga ggtcggcacc gctgacgtgg ggcggccagg
    10441 aggggccggg gtctgcccag gtgaggagcc agtgcgcggc cccggcgatg gcgtcatgtt
    10501 gaccgggagc gatatggccc gcgaggtggg cgagggcgag gaaggcgagg ggaccggcga
    10561 ttccgtgggc catgccggtg gtggcggcgc ccgatggggg gacagggacg ctcggaggat
    10621 gagcgtgggc cgggagccac cagccgggac gagttccctg gtcggtgagg atcatcctga
    10681 tcagggtggt caatgcggcg tgcagaccag gggttgcctc ggcgcggtgg ccggtggcgt
    10741 gggagacgag gaggatgcga ccgatgccgc tcaagccctt gatggcgtcg tagacggccc
    10801 agggcgccca cgatcccgga ctggtccgct gaagctgggc gagggcttgg gcacgggccg
    10861 agagccagct cgtcgcacgc ggggcgaggg cgtggtgggg gccgcgctcg ggcaggtggg
    10921 cggtgccgat gatcagggaa gcagcgaggg cgcccgggcc ggtgtggatg ccgtcggccg
    10981 gtgcgtcacc gaggacttgg gaggctgcgt tccagtggcg gacggcggtg gtcgcgtcgc
    11041 cgaggcaggc gtgcagcagc gcagtgccgg cgagtccgta gcaaagtgtg tgggcggcgc
    11101 gtgcggagac ggcggtggcg acagcccggg taggcccgag ggcgagggcc agctcctggg
    11161 acttggtggc tgagagggcg cggtgctcgt cggtcatggg cgatgaagca gatcggcggc
    11221 gagggtgcgg gcgaggcgtt cgtggctcgg gtcggtgctc agaagccggt tgttgtgcat
    11281 gtggatcagg tcggatgcgc aagaggcggc gaaagcgggg gccaggacgt cgcggtaggc
    11341 gaggagggct ctccgccgtt gggcgtggac ggtggccaga aagggcggga tgagagctgc
    11401 ggcacccccg cgggtgatgg cgcggagggt gtctctgtgg cgacgctggt cccgagtcag
    11461 gcggccgggg gcgagggccc gtcggggctg ctcgggggcg agagctccgg cgatctcggc
    11521 ggatgaggcg gcggcgagaa ggagacgttg gctgtcggtg aggcggaggg cgcggagagc
    11581 aagggcgctg tccgcgtgga agaagcactc ggcggaggcc atggcctgct cgccgccgta
    11641 gcgctcgatt tcctgctcgt acggctccaa gtggaggccg ctgcaaagtc cttgccgacg
    11701 cagccgagcg gtagcggtgg cgagttgggg ttgcacgcgg ctgttcaggg cggtggggtc
    11761 gccgtggacg cggaggcgca ggtggggacc gagcgccggg gtggtgtagc ggagccagaa
    11821 ccagcggtcg atgtcgggcg cggtggtcag ccgctcaagc agtgggctga gttcggtgag
    11881 cgtggtgtcg tggaggtcgc tcggcccggg aagagcagcg gacagccagc taccgccggg
    11941 aaggtggcgt cctgcgtgcg caccgcggat ggctcggcgc gggctgggcc gggacgaggg
    12001 cgggctgtcg cggcgggtga gtgcgacgac gagttcgagg tggtggcgtt cacggtcagg
    12061 gccgggaagg acacggaggg cttcgggcga cccgaggggt tcgtggagcg atcgggtgcc
    12121 tcggtgaacg ctgcggcgta gcagttcgcg gtcgtcgggg tcatggaggt cgagcgggag
    12181 acggcggtcg ttctccgcaa cgaccacggt gccgggcagg gcggggtgaa cagtgcgctg
    12241 ccagacttcc agcgtgctgg cgaaggcagc acggttgcct gccgcggtgg ccagttccgc
    12301 gggcacctgc cagcgggccg ggcacagaag gatgccgtga tagcgcacac gcggcgtgaa
    12361 ggggaaggcg gacagcgggc cccagctcca ggggtgccag gggcgcgtgt tggcatggcc
    12421 gagaagatgc agggcgcggg cggccggcgg tagcagacgg ggcgcgacgc ggctccggag
    12481 gaccggagtg acggggcggt cgtggcgggt cgaccacagc gcgagatgag tgccggagac
    12541 gaccagcgcc aattcctcgg ggatcagatc ctccggtcgc cggggaacgc cgagggggat
    12601 gcgccaaggc gcggtgcccg tctcggcgtt gagcgttccg gtggcagcgg tgcgggcgcg
    12661 gcaggcgatc tcggcgacca tcggtccggt gccgttgccg gcgtgttcgt ccggggtgag
    12721 ttcggggagc cagcgggtcc agcggcccgg tgcggcaccc gcgtcctggg accccgtccc
    12781 gggcacgacc gcgatgtccg gggcttcgct ctcgctgttg agcagctgga tgtggatttc
    12841 agcggtacgg ggcggcggca gcggggacgg gttggcgagc tgggcgaggt ggtggtcctg
    12901 aagagcgatt tcgggtgtac cggtgctgag ggcaccggcg agcagagagg ccagtgcggt
    12961 catacgggac gggctgaggc cctcgtcggt gccgagtgcg tcgtgaaccg tgggcgggcc
    13021 cagacctgct acggggtcga gtgcttcgag cagtggtacc agccggtggc gtccgtagcg
    13081 ggccaggaag cggcggtggt agtcgccgag cggtggggtg cggtgaccga tgcgccagag
    13141 gacggaggcg gcgagcgccg cgctgtcgcc caccgaccac ggcagggaga tctgggcgtc
    13201 ggcaagggtg tccgcaatca gtgggcgggg agtggggcgg agcgagttcg cgaggtccct
    13261 ggccgctgac aggagtggtc gtcggcgagg tgacccggga gtgtgcgcat cggcttcccg
    13321 gagaactgcg gccaggcgcc tcagcgtgtg ggcggacggc gactgcgccg ggagacgacc
    13381 cagcaggtgc tggagcgggt cggcacggag gtcgtcaggg agcaggtcgt cgagcagggc
    13441 cccggccttg accatgttca gtacagcacg cgcgatggtg gcgggggcga cgtcgggatg
    13501 acgtttggag aggtcggcga gcaggtcggc ggccggggcg ccgtccgcgc aggcacggag
    13561 caaccagcgg gagacttcgg tgttccgtac gctgccggtc tccgcgccgc gctctgtcgg
    13621 gcgttcggcc acaaagcggt cgccgcgtga ggtgaccaga ttgctcgtgg tcagggtgag
    13681 ggtgtgcagc agttccggat gttcgtccaa gagctggtcg gcgagggcgg tcagccaacg
    13741 tgcgctgggc atggtgatgg cacggtgcgc ccggcccagc cgcagcgtgg tggcacgggc
    13801 ggtcagggct gccggtgcga ccgcggcgaa gacaccgtgc ggagtggtgc ggctgcgtga
    13861 acgtaggtcg taggcgcgca gggtggctct ggtgcgggcg tccctccggg ccttcgacat
    13921 gtcgatgctc ccggcgaaaa ggaccccctc gatcaaaagg ccgtcagcct catcgccgac
    13981 tccctggtcg gggcggagcg gaacgcgggc catggccacc gggtgcgcgg cgaacagcct
    14041 gcggggcatc gcaccaccat tcgtcggaag cgtggacgtg ggatcggacc ggggagacgg
    14101 ccgggtggac gagcgcccgg ccgcccgcca tgccgatgag cgctcagcag ccggtggtcg
    14161 ggccctgggg cggggactcg ccacagccgt cgccggtggt gtcgccctcc tcctccccac
    14221 cgctcagcca cacgtggagc ccgctcacgg gctgctgcct caggtccagg tcgaaggcat
    14281 cggcgagttc aggtgccggt gccggggacg gtgccgagga tggtgtcatc gggctctcct
    14341 cctgatggga tcaccggcgt catgccggga gaacggtgtg ctgccgatgt gggtcgtggg
    14401 cagcgcggtc agccgatggt cagccggacg ctgggcttct cgatgacgac gcctgggggt
    14461 gcgaggtcgt cgagccggtg gacacggacc tcgggctcgc cctggtggcg tgcagtggtg
    14521 ttccagcgga tgacctcgtc ggcgaacgcg aggccgaggt ctttccggtc ggggccgtgc
    14581 gcgacgacac cgagttcgaa ctggttggcg tgttccggtg cggagcgcaa cgcgaggtag
    14641 gccagggagc tgtcagtcca gatcgccgcc gcgccggtgc ccaggaccca accgaccagc
    14701 ccccgttccg cggcggcccg gctcgcacgc aaccggccgt acggggcgac caccccggcg
    14761 agccacacat cgaggcgggg aaggactccc tcagaaccgg tcagccgtac ccctgtccac
    14821 acctcgtggc caactgagga gaacgccgca cggagcgcgg attcgtcaca gggctgtcgc
    14881 tcgtcgacgg tcagcctgac atcctcgtcg gccagccgga cgatgcgcgg cgcgtccgcg
    14941 cttttccctc gcatggcgag aaagccggag acgatcgtgc tgtcgctcct cagctggtct
    15001 ccgcgccacg cgaaagcgaa cgtgcgggac aggccacgga agcggagcgg gacgaccagc
    15061 cgtccgctgc cggacagctg gtcgagccac gtttccggta gatcggccga cccggcggtc
    15121 acgatgatgc ggtcccaacc gccggcagga gcgtcgggaa ccggcaatgc cccatcgccc
    15181 gttcgcacct gtacccgctg gtacccggca tcgtccagga gtcggcgtgc gcggccggtg
    15241 atgtccggat cgatgtcgag gctcgtgacg acgccggcag gtccgacgag ctcggccaac
    15301 aacgcggcgt tgcagccccc cgagccgatc tccagcacac gcatccccgg agccaaccgt
    15361 gccgcctcca gcatgcgcgc gtgcagccag ggtgccgaga ccgagctgac gacgcgcccg
    15421 tcgtcggtgc gcttggtgaa gatcgcctcg ggcgctccat agacctccgc cgcaggtacg
    15481 tgcggtgcga agcggtgacg cgggacggca cggaacgccg cttccaccgc cggatgcacg
    15541 atggcgccgc ttcgcaccaa ctcgcgcacc atgcgctcgc gcagctcccc ggcgtctgcc
    15601 gccgcctctg ctgtcatgcg gtgttcgttc atcgcgctac gtgaatcctc actgaaccct
    15661 tgcctgtctc ccgccgatgc ccgagacctc cgaagtgagc ccgcctgaca ggaccgatag
    15721 gacgacgccg acgtggaaag ccgtggccgt gtgcccccga gaactcggcc acgtcccaag
    15781 gacacctcag aatccgaccg gcgaatcact gccgtggcgg acagctggca tcacctcaaa
    15841 gctcggggat gcgtcgcgtt cggcgcgagg gcgcatgggc ggagcacttg gcgcgtatgg
    15901 cggcacggcc gtcgcccgtc tcggggcggc cggtagcggg ccgcggggca gtgtcgctga
    15961 gtcgggagtc gtcagcgttc ccaagctgtg gatgtcggac gtccacccgt gtgagcgatg
    16021 gtccgcgagg cgagacgttg acgcgctgcc accgggctcg gtcagtcgga gtggatgacg
    16081 gtgaccacgg acacggtcag gacgcctgtg ctgacccagt agacggtgat ggcgccggcc
    16141 agggtcgcct gccgccgatc gcggtttccg ccgagtgcct gtccgtgggc gtagggatcg
    16201 acagcgatct cggccacggc ggcctcgaac cgccgacggc gcgggctgct catcttccgc
    16261 agggcgtcgc gcgcctcgtt gctgtactgg aggcggtacc ggcggctcac gcgtccaagt
    16321 cctcggccgc gatgaaacct gtggagtccc cggcctccag ccgtcggaac accgcttcct
    16381 gggcggcccg taggtccggg cgggtctcct gcgcccagtg gccgagcagc aactccagtt
    16441 ccccggcggc agccgcgccg accgcctcgt cgaactgctc gcgccgctcg ggcggcagag
    16501 cggccctgat gccgttgatg ctggcgggca gttcgatctc ctcgccgtcc agccacgttc
    16561 gccacaccgg cccgacagga ccgccggtcg tctcgcccat tccgtgcctc ccgaagtgct
    16621 cgtcgccacg gtaagcgcgg cgggtccgca gcatgaccag gcgcacgccg tcggcccgtt
    16681 cccccgccga ggtctgcggg ggaacgggcc gtgagccggt ggggaaccgc cggtgatgcc
    16741 tcggctgtcc cttgagccgt atggctacca ggtcttcccg gcctgctccc ggatggtgtg
    16801 gttgacgcgg ttgaagaagt tggtcatcgc gatgtgcagg gtgagggagg ccagttgctt
    16861 ctcgtcgaag tgggcggacg ccgcctccca gaccgcgtcg gtgaccccag gcgcgccgtc
    16921 ctggatgcgg gtggccgcct ccgcgagcgc gagcgccgcg cgctccggct cggagaagaa
    16981 cggcgtctcg cgccacgcgg ccacctggtg cagccgttcc tccgtctccc cgtgccgctt
    17041 cgccgacgcc actccggcgt ggacgcacgt gctgcacccg ttgatctggc tggcccgcag
    17101 atggaccagt tcgagcacga gcgggtccac accaccggcg tgcaccgcct tgatgagatg
    17161 ctgcaccgcc gtcatcacgt cgggactcac cggagtctcc atgcgcactg ccatcggtcc
    17221 tgctccttcg gcgttcgttc gtcggttacc cgggccgctc ccggcccgtc atcacccatg
    17281 acggaacgcg ccagagaaag gtgacaccat ggccgacccc caccccgccg actccgtggc
    17341 cgaggcgttc gaggcccaac gcgaccggct gcgcgcgatc gcccaccgcg tgctcgggtc
    17401 gcacgcggac gccgaggacg tgatccagga gacctggttg cggctgtccc gccaggaccc
    17461 ggcgaccatc cgcaacctgc ccggctggct gaccacggtg gtcggccgga tcagcctcga
    17521 cgtcctcagg tcgcggcggg cccaccccga ggcgtccctc gacgcccggc tgcccgatct
    17581 cgtggtgacc gtcgacgacg gaccggggcc agaggacgac gtggcgctcg cggactcggt
    17641 cgggctcgcg ctcctcgtcg tcgtccagtc cctcgggccg agcgaacgca tggcgttcgt
    17701 gctgcacgac ctgttcgcgg tgccgttcca cgacatcgcg cagatactcg gcaagtcgac
    17761 cgacgccacg aagatgctgg cgagccgcgc gcgcaggaag gtgcgggcga ccgagcagcc
    17821 gacggcctcg gggcgggagc ggcgcgaggt ggtcgacgcc ttcctggcgg cagccaggga
    17881 gggcgacttc gacggcctgc tgcgcgtgct cgaccccgac gtgcggctga ccgccgaaac
    17941 ggcgggtggg atggtcgtca gcctcggcgc caccgaggtc gccaccggtg cccggctggc
    18001 cgccggagcg gcggcacggg ggcgggccgt tctggtgaac ggccttccgg ggtggctggc
    18061 ctggcacgcg gacggcagtc cgctctcggt cctcgccttc agcgtcaccg acggccggat
    18121 caccgccatc gcggccgtca gcgacccggc ccggctcgcg gcgatggacc tgccggaacc
    18181 gcgatgagcc acccaccggg ccgtcggccc gttcccgccg gggcgtgcgt ggggggaacg
    18241 ggccgtgggc cggtgggggt tacagggtgc cgtcgacgat gtgctggcgg aaggcgtccc
    18301 actgtggggt ggtccagcgg agtggggtgc ggtgggggtc cttggagtcg cggatggcga
    18361 tgccgccgcc ggggatatcg gcggcctcca cgcactgcgc cgcgccgttg ctgcgggacg
    18421 atctgcgcca ggtggcgttg gtgaggtcga cggcgtacag gtcgtccgtg cgggcgttca
    18481 cttccggttc ctttcgataa gggtcctgat gagctgccgc gagtcgtcca cggacagggc
    18541 agcggcgacg acacgttcga aggcggactc gaagaccttc acgtcttccg ttccctccac
    18601 gaagtaaccg ccctggatat tctccaggtt gaccacggtg gcccatgggt gtggaaagcg
    18661 tacgatctcg aagaggccga gcatgccggg attcggggtg gcgatcagcg gcatgacctg
    18721 gatggtgacg ttcggcagct ccgtcatgtc cagtaggtgc ttcagctgct ggcgcatgag
    18781 gaacggttgg ccggcgaacc gctggtgcag cccggcctcg tggaccactg cccacagctt
    18841 caacgggcgc ccctccggcc tggtcgtgag aatggcctgg cgcatcttcc ggatttcagc
    18901 aagggccgcg acctcctcag aggtatgcgt ggtcgagatc ccggcgatga tttcgcgtgc
    18961 gtacgggccg gtctggagca gccctggcac caggcccggt gtgtagatgt ggacgctctc
    19021 cgcgtccgtc tccagcgtca ggtaatcctt gtagttcagg gcgacgacat ccccgtacgc
    19081 ctgccaccag ccctgtttgc ccgcgtcctt ggccaggccc tccagtgctg cgatcacctg
    19141 ggggtcggtg acgccgtact gggacaggag cttggcgacg tcctgcggca gcaggcgggc
    19201 gacggccgtc tcgatgcggg acagcttgct gtcgtcccag cccatggcgg tggccgccgt
    19261 caccaaggtg accccggcct cgtgccggta cctccgcagg gtcccgccga gccgacgcct
    19321 gcgcaatgtt gggatggccc gaacattcgg catggtgcta tttcacaccc ctccggtgct
    19381 ggaaaagaag gtttgggtgc gcggaggtac cgcgcgggtg tggcagacgc ggtgcgaggt
    19441 gccctttctc ctgtcaaagg cgctgccaag cttgcctgtt gacttcctgg tgccgcattc
    19501 ttcctttccc agcgcgtgat cgcaggccgt tcccgcgcga ttacccggag tcgaacgcct
    19561 atccggcgac gaggggtcac catgaccacg atctgccgta cgttcccgcc caccccaccg
    19621 cccgcctggc tcgtgccggg catccgcgtc cgcgacgccg cctcccgagg gctgggcgtc
    19681 gttctgctgc tccaggacgc gcggcgcgag gtcagtaccc ggtggataag ccgtcccgta
    19741 cgggcgttgc tccgcgccga ctgctggggc ggcccgctgt ggtgggcccc ggccgccgga
    19801 ctgtccccgg ccgacgagtg cgtccgctgc ctcggtcact gcccgttgcc cgccctcgcg
    19861 tgagaaggac gtggattgct atgtctgttc gctgtgtccc aaggtccgca cggcctttga
    19921 cctgggggcc gcaccagctg cccgttcccc atgccgccgc gtggagcgcg gaacggaccg
    19981 ccgtcgcggg cgcgttgacc gtcagggccg acggggccgg gctggcctac cgggacgaga
    20041 ggccgggcga ccgggacggg cagggcgtgc tgtgggcgcg gatcggccag gcgcagggcc
    20101 aggggcggcc caacttccgc gcgctgcact cgggtcggca gcgcggcgcg atgctggaca
    20161 agctgtgcca ggtgtgcggc gggcaggcga gcaggaccgg ccggggctgg ctgttcctgc
    20221 tgcaacgccc ggccccgccg gaggcccggg actggcccga ggggctgctc tgcacgaagc
    20281 ccccggtctg ccgcccgtgc gccgcgctgg ccatgcgcca ctgcccgcac ctgtccgacc
    20341 cggtggtcgt gcggtcgcgc aagccgagga catggggggt gttcggcggc ttcttcacgc
    20401 ccgcgccgga cggcggcctc gccccgcacg ccgactcggc cctgccctac ggcgacgcgc
    20461 gggcgccgtg gttcctcgcc tcccagctcg tcgtcgaact cacccgctgc acggtcgagt
    20521 ccgcgccacg gcccgcccgg tgaacgggcg cccacgcctt cacaggcgga agcggggggc
    20581 ctcgtcccgt ggggggcggt aggcgcacat cgtgccggtg gagacggacg cgcgcaggtg
    20641 ggcggcgagt tcggggtggc gggtgtcgag gcggcgcagc gtgtcgcgga tgcgcgcggt
    20701 gaccgttttg cgggcgcgtt ccgcctcgtc gcccaggcgc ctggtgcgcc cgccgagacc
    20761 ggcggccgtg cgcaactcgg tgagcagcgc ggcgcgttcg cggtcgaggt cggcggcgcg
    20821 cgccgcgtcg ccgcgcgccg ccgcgcggtc gacttcgtcg tccagttgtt cgaggtggcg
    20881 ccggtagcgt gccttcgcct cgtcgtcgag cacggggtcg ccgccgtaca gcggcgcctc
    20941 gcccgccggg tcgagcagcc gcccggcggc gatgtcctgg cccggctgcc cgatgagccg
    21001 ccacaggtcg cgcagcccct tggcgtccgg caggtgaacg gtgcgccccg cgtaccgcag
    21061 ggtccacacc gagccgtcga agcggaactc gtccgtgcgg cgggccacat ggggtgcggc
    21121 cagggcggtc gccgcctgct cctcgatgtg ccgcaggccc agccgcgcgg cctcctcctc
    21181 cgcctcgcgc agcgtcgccc gcgcggtgtc cgcgtcgccg ggccgccccc ggccgagcag
    21241 cgaacggccc aggcccaggc gcgccctgac cgcccacggc cgggccagca gccggtcggc
    21301 cgaggtggcc gcctcggtgt acccggccac cgccgcgtcc cagcgttcct ccgcctggtc
    21361 gagcagcgcc gaccacaggg cccaggggcc gccgatgtcg aagccgaaca ggcccaccgc
    21421 ccactgcccg gtcagcggcg ccagctcggc gcgggcccgc gcgatcaggt ccgcgtcgcc
    21481 cgacagggcc gcggcctgcg cctggaaccg cagccacagc gcctcggcgt accgggggcg
    21541 tggcaccgag cgcgacgtct cgtactgccg caacgcggcg gccgcgtctc cctgttcggc
    21601 ggcggcgatg ccggcgacca gctccgggtg cgcgtgacgc ttggcggaac gcgccgcgtt
    21661 cgcctcggcg agttcgggga agcggccctg cgccaggagg aggcagcggc gcatgtggtc
    21721 gcggaacgcc cccatgtgct gagcattgcc ttcgcggcgg gtcagctcga cgagttcggc
    21781 gtgcaggtcc tcggcctcgg tgaaccgtcc gtggagcacg gcgacgatcg cgcggtccac
    21841 cgtggccgac agccggtagc gcggccgtcc cgagcgttcc gccgaggcca ggaacgcgtc
    21901 cagttggtgc aggtaggcgg ggtcgccgcg ttcgaggagc gtgacccagc cgagcgccat
    21961 cgagaagtgg ccgaggtcgc cgtcgccgtt gcggcgggcg aggccggcca actcggtggt
    22021 cagcgcctga cgttcggcgg ccgtgccggg gccccagatg gcgtcgtgca gggaccacag
    22081 gctgaacgcg agcgcgtcct cgtcgccggc gcggcgcgcc agcacggcgg agcggatgct
    22141 cagttcgcgc gcgagccgtt ccagcgtcgc cgggtcgtcg ccggccggcg gcggcctccc
    22201 ggcgggggtg ccgacgagcc gccggtgcgc gtcgtgcagg aggtcggcgt gcgaccggtc
    22261 cacgccggag cgcagcgtcg cgccgtgcga gtcgtactgg gccagggcga cgcgggcgag
    22321 cagttcggcg tcgtcgagcg cgcgggcctc gtcggcgcag cgcgcgaagg cggcggccgc
    22381 tcccgccgag tccccggtgt ggcgcagctc ggtggcgagg tcgaggccgg ccaggacgtg
    22441 gcggcgcggc ccgagccctt cggccaggtg gaaggcgtcg cgcatgtgtc cgagcgattc
    22501 gtcgaacgcc atccgcccct tggcgtcctc ggcggcggac cgcaggagtt ccacggcatg
    22561 cgcggggtcc agctcgtcgc ccgcgaggcg cgcgtgccgc gccaggtcgg cgggcggcac
    22621 gaggtcggag agctcgggcg cgccggccag cgcgcggacg actgcggcgt gccggcgccg
    22681 ccgttccgcg ccgtccagcg actcgtgcag ggtctcgcgc atcaggtcgt gggcgaacgc
    22741 gaaccggtca gggccgttcc gcgtgacgag ccgggccgcc tccgcgtgcg cgagcagccg
    22801 gtccacctcc gtgccggttc ccggcgcggt ggccgcgagc acccggcggt ggaacgcgcg
    22861 gccgagcacg gcggcccggg tcagcagcgc cacgacctgc tcgggcagca gcccgagccg
    22921 ccgccgcacc gcctcgcgca cgcctggcgg cacgccggtg ccttcgccgc cgtgccacag
    22981 gcgtgcggtc tgctccacga agaacgggtt gccgccggtg tgccggtgca cccgggcggc
    23041 cagggccgcg tccggggcgc cgcccgtggt gcgggccatg agcgcgccga cctcgtgcgg
    23101 ggcgaggccg gtgagcgcga gggtggtggc cctggacacc aggggcatca gcagcgcgtg
    23161 cagcgggtgg tcctcggcgg cgacctccgt gtcgcggtag gtgcagatga gcagcaggcg
    23221 ttcgaaccat gtgtgccggg cggcgaagtc gagcagccgc agtgatccgg tgtccgccca
    23281 gtgcaggtct tcgagcacga gcgcgacggg ccgccgctgc gacacggtga ccagcgccgt
    23341 cgtcaccgcg tcgtgcaggg cgaagctctc tgccctgccg ccgtccccgc cggtcgtcca
    23401 gcccgccagg tcggcgcccg ccgcgtgttc cgccgccgcc cactcctcgc ccgtcgcggc
    23461 ccgccgcagc ccgcggacca cctgggtcca cggccagtgg cccggggcgt tctccgcgtg
    23521 ccagcaggag ccgccgagca cgagggcgcc gcgcgccctc gcctcctcgg cggcgcccgt
    23581 gaccagcgtg gtcttgccga tgcccgcctc gcccgtgacc aggacgaggc cgccgtggct
    23641 ggtcgtggtg cgggcgatct cggcgcgcag cactccggcg gcgtgctccc gcccgatcat
    23701 ggtgtcgaac acgtggtccc gtcgttcgtg ctcgcgtcag ccgggcagcg ggccggaacc
    23761 ggtgtcccgt tcgccgttgg acgccgtgcc gttcggcgcg gtgcgggtgg tgccgcgcac
    23821 ccggaggtgg tcgagcaggt gccgggtcgc ctccgccacc tcggccaccg cggcgtcgaa
    23881 cacctcgcgg ttgtgcgccg cgggcgacct gaatccggac accttgcgca cgtactggag
    23941 ggccgcggcg cggatgtcgt cgtcggtgac ctcgggcgtc gccggcgggc gcaacgtctt
    24001 gatgcttcgg cacatgccac cagtgtgcac ccgtcccgaa cgcccatcc
//
