LOCUS       NZ_CP021121            22286 bp    DNA     linear   CON 31-JUL-2024
DEFINITION  Streptomyces marincola strain SCSIO 03032 chromosome, complete
            genome.
ACCESSION   NZ_CP021121
VERSION     NZ_CP021121.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces marincola
  ORGANISM  Streptomyces marincola
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6287975)
  AUTHORS   Ma,L., Zhu,Y., Zhang,W., Zhang,G., Tian,X., Zhang,S. and Zhang,C.
  TITLE     Complete genome sequence of Streptomyces sp. SCSIO 03032 revealed
            the diverse biosynthetic pathways for its bioactive secondary
            metabolites
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6287975)
  AUTHORS   Ma,L., Zhu,Y., Zhang,W., Zhang,G., Tian,X., Zhang,S. and Zhang,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2017) Key Laboratory of Tropical Marine
            Bio-resources and Ecology, South China Sea Institute of Oceanology,
            164 West Xingang Rd., Guangzhou, Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method :: Hierarchical Genome Assembly Process v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 165.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002128305.1-RS_2024_07_31
            Annotation Date                   :: 07/31/2024 06:55:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,513
            CDSs (total)                      :: 5,438
            Genes (coding)                    :: 5,343
            CDSs (with protein)               :: 5,343
            Genes (RNA)                       :: 75
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 95
            CDSs (without protein)            :: 95
            Pseudo Genes (ambiguous residues) :: 0 of 95
            Pseudo Genes (frameshifted)       :: 19 of 95
            Pseudo Genes (incomplete)         :: 88 of 95
            Pseudo Genes (internal stop)      :: 2 of 95
            Pseudo Genes (multiple problems)  :: 13 of 95
            CRISPR Arrays                     :: 12
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:29:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2928508
            Orig. end                         :: 2950794
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP021121.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Key Laboratory of Tropical
            Marine Bio-resources and Ecology.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22286
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="14"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22286
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22286
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12286](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12286)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    562..573
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     misc_feature    623..636
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.99"
                     /tool="antismash"
     misc_feature    complement(714..728)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.37"
                     /tool="antismash"
     misc_feature    1103..1118
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.65"
                     /tool="antismash"
     gene            1152..3026
                     /locus_tag="CAG99_RS12795"
                     /old_locus_tag="CAG99_12785"
     CDS             1152..3026
                     /GO_process="GO:0006813 - potassium ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014181524.1"
                     /locus_tag="CAG99_RS12795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_12785"
                     /product="TrkA family potassium uptake protein"
                     /protein_id="WP_086159468.1"
                     /transl_table=11
                     /translation="MIVSGDDVLAVRLGAELHDVYRERVTLIVPPAPPSGGWAGPRGLV
                     RVSALIGRLSSAVARNDPSVREIEAAEPTEDVLRQAGATEAAALALVHEDDETNIRGAL
                     AARRLNPRLRLVIRLYNRKLGQRLAELLDQAADVTLPGLDAAALDVSTIVLSDADTAAP
                     ALAASAVAGTRKVIAADGLLLRAAERPPPGPGEIADPGLCTLALLSATAQDPAGTEGSD
                     RSGAAAPLLLPDDAAVAAATGRGTIVLETVAHTGPPLPPRRLARRGAPLAEVFTVRLRW
                     ALAAVAAAVCALAVALWAATDDHPLRAGYLTLLDLFAIGESAVGEPVARQTIQLVSGLV
                     GLALLPILVAGALQALGAFRGSAALRRPPRGLSGHVVLLGLGKIGTRVLAQLRDLDIPV
                     VCVEEDPDARGVPLARRLGVPVVLGDVTQEGVLESAKIERASALLAVTSSDATNLEAAL
                     CARGVQPGLRVSLRIYDDDFATAVYRTLRAAHPGALTRSRSVSTLAAPAFAGAMMGRQI
                     LGAVPVERRVLLFAALDVAGLPRFAGRTVAEADRAGAWRIVALDTAEPADRHPDLAAPR
                     PREENADAAGLLWNPHPGYVLRPEDRVVVAATRLGLAELLGRRRGPAL"
     misc_feature    3136..3151
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.42"
                     /tool="antismash"
     gene            3261..5618
                     /locus_tag="CAG99_RS12800"
                     /old_locus_tag="CAG99_12790"
     CDS             3261..5618
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346099.1"
                     /locus_tag="CAG99_RS12800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_12790"
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="WP_086162168.1"
                     /transl_table=11
                     /translation="MSADPFQQPAAPPRGQAAPPPEAAAGPVAADSHDVIKVRGARENN
                     LRDVSLDIPKRRLTVFTGVSGSGKSSLVFGTIAAESQRLINETYSAFVQGFMPSLGRPD
                     VDALHNLSAAIVVDQERMGANSRSTVGTVTDAYTMLRIVYSRLGTPHIGTSSAFSFNSP
                     EGACQDCEGMGQVSRVDIDQLVDRELSLNEGAITVPGFGVGTWYWQVMANSGLFDNDMK
                     LKDYPAELWEDFLHKPATKIKAGANTLTYEGLVTKVNRVYLSKDRETMQTTLRAFVDRA
                     VVFAACPACRGTRLSAAALSSTINGVNIAECSAMQISDLAEFVRGLDAPSVAPMLGALR
                     DLLGSLVEIGLGYLSLDRPSGTLSGGESQRVKMVRHLGSSLTDVTYVFDEPTTGLHPHD
                     IQRMNDLLLRLRDKGNTVLVVEHKPEVVAIADHVVDLGPGAGTSGGEICYAGDVAGLRA
                     SGTRTGRHLAHRAALRETVRTPRGHLSITGAATHNLRNVDVDIPVGVLTVVTGVAGSGK
                     SSLIHGALPGRDGVVVADQSAIRGSRRSNPATYTGLLDPIRKAFAKANGVKPALFSANS
                     AGACANCNGIGLVYTDLAMMAGVASVCEECEGKRFTPEVLTYTLDGKDISEVLEMPVAE
                     AHKFFRTGQAQAILGRLMDVGLGYVRLGQPLTTLSGGERQRLKLAIHMAEKAATYVLDE
                     PTTGLHLADVDQLLALLDRLVDAGNTVIVIEHHQAVMAHADWLIDMGPGAGHDGGQVVF
                     TGTPAELVARGDTLTARHLREYVTGTAPATGR"
     gene            complement(5790..6398)
                     /locus_tag="CAG99_RS12805"
                     /old_locus_tag="CAG99_12795"
     CDS             complement(5790..6398)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016407 - acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Mac"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156: Chloramphenicol acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676985.1"
                     /locus_tag="CAG99_RS12805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_12795"
                     /product="sugar O-acetyltransferase"
                     /protein_id="WP_086159470.1"
                     /sec_met_domain="Mac (E-value: 2.5e-09, bitscore: 35.5,
                     seeds: 568, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRDDERDVLDRMGRGLVYTESEAVFLDERRRADLIFAYNHTPPG
                     EADKRRSLLRAILGSVGERPALHPPFSAAFGSNVHIGDDFFGNVNLAFVDDVEIRIGHG
                     VMTAPSVTLTTTGHPVHPARRVDFARFSEPIVIEDKVWIGSNVVVLPGVRIGYGSVIGA
                     GSVVAKDVPPMVVAVGTPCRVLRDITDDDLTTRTSAADR"
     gene            complement(6463..6762)
                     /locus_tag="CAG99_RS12810"
                     /old_locus_tag="CAG99_12800"
     CDS             complement(6463..6762)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CAG99_RS12810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CAG99_12800"
                     /product="hypothetical protein"
                     /protein_id="WP_086159471.1"
                     /transl_table=11
                     /translation="MPGRGRPLREAGGTAGRPAAEGCRDSEPAADLIRWALLSEDETGA
                     ALGALRATGMALYVLGNFHGWRLLDSWLATADRDVRVRRLLTERLLPADVRPAG"
     gene            6999..8207
                     /locus_tag="CAG99_RS12815"
                     /old_locus_tag="CAG99_12805"
     CDS             6999..8207
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019431870.1"
                     /locus_tag="CAG99_RS12815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_12805"
                     /product="S8 family peptidase"
                     /protein_id="WP_086159472.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 5.9e-20, bitscore:
                     70.0, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRVSGRSRAVAVLTAALLLPATAAALPAGAAPAGAAPVGHVLGA
                     PERDAVDGSYLVLLADGGKPAAEAGTRLADRYGVRVVDAYDAALTGLHVHATASQARRL
                     AADPAVRAVEQDSVLRALPASTQPNPPNCGLDRIDQPDLPLDGSFTYPDSAGAGVTAYI
                     VDSGIAYGHADFGGRAGPGYDATGGNGADGNGHGTWVAGLVGGTNHGVAKSADLVSVKV
                     LNDAGAGTVAGVVAGIDWLTADARGGPAVAVVALGGVASQALDQAVRASIASGVTYAIA
                     AGGSGDDAGRYSPGRVTEAITAAASDCRDRVAGFTNHGPVVDLFAPGVGIASTWPNGTA
                     VLSGTSGSAAFTAGVAVLYLGDHPSASPAQVGQAIDQAAAVGRLTGVPVGSPNKLLQVV
                     PVD"
     gene            8264..8659
                     /locus_tag="CAG99_RS12820"
                     /old_locus_tag="CAG99_12810"
     CDS             8264..8659
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016470415.1"
                     /locus_tag="CAG99_RS12820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_12810"
                     /product="hypothetical protein"
                     /protein_id="WP_086159474.1"
                     /transl_table=11
                     /translation="MRTSVLRAVGVATTAYGVAVTVRPGLLAKPSGLAGHDGRTAAEVR
                     TSLRPLGLREAACGLALALAPRGAALRTAAAVRLAADFGDAVLLGATLPGPVRRGGAVA
                     VSVGWGALTLAGLLLPESPNARRAAAR"
     gene            9035..9892
                     /locus_tag="CAG99_RS12825"
                     /old_locus_tag="CAG99_12815"
     CDS             9035..9892
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010042199.1"
                     /locus_tag="CAG99_RS12825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_12815"
                     /product="maleylpyruvate isomerase family
                     mycothiol-dependent enzyme"
                     /protein_id="WP_086159475.1"
                     /transl_table=11
                     /translation="MDTSRGDGAGHAWLGAPIDARPLFAPEHAALMALLRDLAPADWSR
                     EAVPGWTVRDLAAHILGDCYGRLARARDGHRGGPAPEPGETLETFIHRVNAEWVAAFSR
                     VSPAALTDTLDLVGGQTVRYFEAADLDSPSLGVSWAGADPAPMWLDSARELTEFWTHRQ
                     QIRHAAGRGTDPDPRLWSVVLDTFLRALPHTLRAVDAPVGTQLRVRIDGPAGGTWTATA
                     TGERWSLAPPAGERPAATLELDPETAWRLCTRGIAPDDALTLARLHGDRDLAAAACRIV
                     SIVH"
     gene            complement(10001..12286)
                     /locus_tag="CAG99_RS12830"
                     /old_locus_tag="CAG99_12820"
     CDS             complement(10001..12286)
                     /EC_number="4.2.3.-"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009714107.1"
                     /locus_tag="CAG99_RS12830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_12820"
                     /product="terpene synthase family protein"
                     /protein_id="WP_086159477.1"
                     /sec_met_domain="T1TS (E-value: 4.8e-82, bitscore: 275.0,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPFELPAFYMPYPARLNPHLDAAREHSPRWAARMGMLESSGIW
                     TGADLDAHDYPLLCAYTHPDASADDLCLVTDWYVWVFFFDDHFLETFKRTQDRPGGKAY
                     LDRLPAFMPLDPAAGTPEPTNPVEAGLADLWARTVPAMSPAWRRRFAESTANLLNESLW
                     ELSNINAGRVPNPVEYIEMRRKVGGAPWSAGLVEYAARAEVPAAVAASRPLRVLRDTFS
                     DGVHLRNDLFSYQREIEDEGEMSNGVLVLETFLACSTQEAAEAVNDLLTARLQQFEHTC
                     VTELGPLFAESGLDAASCAAVLAYAKGLQDWQSGGHEWHMRSSRYMNGAAGGGAAHAPA
                     PGLAALPVLPGLPPGLGTAALRAPGGARRGPGGVTTTRRAEAARARRFRHVPHRRVGPS
                     LLPDFPMPFDLRLNVHLDGARTRLAAWAHRVGILDGAPWTEAKLYDYDLPLCAAGLAPD
                     APADALDVVSGWLAWGTYGDDLYPVLFGRTHDVAGARAVTERIAQFMPVEDPDAMPVPV
                     SGLERGLADLWPRTAGPMTLPARRRFRETIEVMTASWVWELDNQAQNRIPEPVDYVEMR
                     RQTFGSDLTMCLARLGHGPKVPQEVYRSGPISSLENAAADYACLMNDVFSYQKEIEFEG
                     EIHNGVLVVQDFFDCDYPAALRVIADLMAERMRQFQHVAAHELPVLYEDFGLDDEVRGI
                     LDGYVRDLENWLAGILNWHRFCRRYRESDLRRHAQGALWPLGAPTGLGTSAARITRLLG
                     PPAARRAS"
     misc_feature    12270..12285
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.81"
                     /tool="antismash"
     misc_feature    complement(12356..12370)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.4"
                     /tool="antismash"
     misc_feature    12359..12374
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.4"
                     /tool="antismash"
     misc_feature    12359..12377
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.68"
                     /tool="antismash"
     misc_feature    12489..12502
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.42"
                     /tool="antismash"
     misc_feature    complement(12492..12508)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.5"
                     /tool="antismash"
     gene            12638..15277
                     /locus_tag="CAG99_RS12835"
                     /old_locus_tag="CAG99_12825"
     CDS             12638..15277
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019436475.1"
                     /locus_tag="CAG99_RS12835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_12825"
                     /product="rhamnogalacturonan lyase"
                     /protein_id="WP_255308077.1"
                     /transl_table=11
                     /translation="MTPADRRRRARNRRLIAAPLAGLMTAGLLAAAGTGPARAAAPAAQ
                     PAAEPAARGAERPAPGGVQLEHLDRGLAAVATGEGVFLSWRLLATEVTGHSETGLTGAD
                     FHVYRDGELLGTVTDSTNYLDAEAPAGAEYRVAAVVDGVEVDLSEPVSPWSDGYYELPL
                     NKPADGVTPAGEAYTYSANDVSVGDVDGDGQYEYVVKWYPSNAKDVSQVGYTGNVYLDT
                     YRLDGTLLHRVDLGVNIRAGAHYTQFLVHDFDGDGRSEIMFKTAPGTKVTRYHPDGRVA
                     SERHITMPREDIRAGYGHDDDYRMSAEDYYAHVVGMFEDWHEHPEVVAGNWPATLEEAF
                     GIAPAHDYPLSREDAEALADHFIDAYAPSRSARNNLRAFEGFILEGPEYLSVFDGATGR
                     ELDTVRYEPGRHDDGLMWGDYAMARIEPGNRVDRFLSTVAYVDGQHPSAVFARGYYTRS
                     TLVSYRWDGHRLREDWNVDSGWTPMSNPFNDGPHGVDGTDPEFGTLTTQGFHSLSAADV
                     DGDGRQEIVYGSATIDDDGSLLYSSFAEMPPGSADPGAQARLGHGDAMHVTDIDPARPG
                     LEIYTVHEGGASAPLGYALRDAATGEVIYGEYTGVDTGRGMIGDVDPDEPGLETWANHP
                     EGGSDPDGVGLWTADGRRLGERTPGTNQSIRWAGDLTTQIVAGYGYLGQDTVIEDWRRG
                     TLLTAEGTRTNNHTKGNPALVADVLGDWREELLVPTADSTGLRLYVSTELTGHKLYTLM
                     HDPQYRAEVARQQTTYNQPSYTGFYLASDMDFSQVPVPDLWTPGGVAALADDLARRVAD
                     GEVSFLSGLLLKPWTVQAELHMARGDHASAARALERFTAKLEHLRGVSDPARAALTHRA
                     ETLIRTLR"
     gene            15449..15877
                     /locus_tag="CAG99_RS12840"
                     /old_locus_tag="CAG99_12830"
     CDS             15449..15877
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024953.4"
                     /locus_tag="CAG99_RS12840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_12830"
                     /product="DoxX family protein"
                     /protein_id="WP_086159478.1"
                     /transl_table=11
                     /translation="MEPLAVLVVGYAVVRLAGLLGVDVVDGWQPALRVALALMFLFTAA
                     SHFHPRTRPALIGMVPPSLPRRERLVDLTGMLQLAGAIGLLVPATRRLAAVGLLLLLVA
                     MFPANVSAARRAVAQGDPLGPRTAIQLVFIAAVALTLL"
     gene            16020..16820
                     /locus_tag="CAG99_RS12845"
                     /old_locus_tag="CAG99_12835"
     CDS             16020..16820
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018519043.1"
                     /locus_tag="CAG99_RS12845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_12835"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_086159479.1"
                     /transl_table=11
                     /translation="MSPDIAARFDELVAEGEAVPTEGWDFSWFAGRATEERPAWGYSSL
                     LADRMRAAEAALDMQTGGGEVLAAVPVLPPVLAATESWPPNVGIARRKLAPFGATVVAM
                     EDDAADLPFPDGHFDLVVSRHPVVTRWDEVRRVLRPGGTYLAQHVGAGSVRELTEFMMG
                     PNPFPPPPPARPFTTRSGATPTGAVAVAESAGLVVVDVRQQALRMEFHDIAAVVHFLRK
                     VIWTVPGFTVDAYRERLAELHDFIERHGPFVAHAQRFLIEARRP"
     gene            complement(16846..17436)
                     /locus_tag="CAG99_RS12850"
                     /old_locus_tag="CAG99_12840"
     CDS             complement(16846..17436)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009714948.1"
                     /locus_tag="CAG99_RS12850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_12840"
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_086159481.1"
                     /transl_table=11
                     /translation="MRKLVYYIAVTLDGRIAGPGGEYDFFPLGDEEQAAGYAERMNARY
                     PEFLPTAGREMFGLAGVPNRRCDTVVMGRGTYLPALDAGVTSPYAHLRQYVVSRTLDAG
                     TDPDVTVVPSDPLGLVRRLKQEDGGLDIWLCGGGRLAGELLPEIDELIIKSYPVVAGAG
                     PSVFDGAFDPTLFTPTARETFDNGVLVTWCTAR"
     gene            17504..18079
                     /locus_tag="CAG99_RS12855"
                     /old_locus_tag="CAG99_12845"
     CDS             17504..18079
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003985704.1"
                     /locus_tag="CAG99_RS12855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_12845"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_086159482.1"
                     /transl_table=11
                     /translation="MVRRNDERRAALLDAAIEVLAQEGARGLTFRAVDTGAGVPKGTAS
                     NYFANRDELFTQVGERFYERLQPDEAAMARMRDAPRDRDTYVTLMRELVGRVSAFRTGY
                     LALLELRLEATRRPRLREVLTARVRADADANVAYHEASGLPGDATAVRLLMLTLNWLIL
                     EQLTLPDLFSEDERERLVQAAVERIVLP"
     gene            complement(18194..18964)
                     /locus_tag="CAG99_RS12860"
                     /old_locus_tag="CAG99_12850"
     CDS             complement(18194..18964)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (14-171). E-value: 6e-11. Score:
                     34.5. Matches aSDomain:
                     nrpspksdomains_CAG99_RS12860_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061598.1"
                     /locus_tag="CAG99_RS12860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_12850"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_255308078.1"
                     /sec_met_domain="adh_short (E-value: 3.6e-32, bitscore:
                     110.1, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 2.6e-35, bitscore:
                     120.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQHSPAPGRFHQRVTIVTGAGSGIGRAAALALAAEGAHVLGVGR
                     RPGPLEETARAHPGVVAFPADIRAPGAAEAVVGAAVDRWGRIDVLVNNAGGMDAMTLPE
                     VTAERVARMFDLNVIAPSLLARAALPHLRETRGSILNVSSTYGHRPGAGVSHYAASKSA
                     LEQLTRSWALELAAEGIRVNALAPGPTESEALHAAGLPEEVIAAVKAEETARIPLGRRG
                     EPEEVAAWLLHLADPAATWLTGQVLAVDGGLNLT"
     aSDomain        complement(18452..18922)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CAG99_RS12860_PKS_KR.1"
                     /evalue="6.00E-11"
                     /label="CAG99_RS12860_PKS_KR.1"
                     /locus_tag="CAG99_RS12860"
                     /protein_end="171"
                     /protein_start="14"
                     /score="34.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VTIVTGAGSGIGRAAALALAAEGAHVLGVGRRPGPLEETARAHPG
                     VVAFPADIRAPGAAEAVVGAAVDRWGRIDVLVNNAGGMDAMTLPEVTAERVARMFDLNV
                     IAPSLLARAALPHLRETRGSILNVSSTYGHRPGAGVSHYAASKSALEQLTRSW"
     misc_feature    complement(19002..19015)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.93"
                     /tool="antismash"
     gene            19021..19374
                     /locus_tag="CAG99_RS12865"
                     /old_locus_tag="CAG99_12855"
     CDS             19021..19374
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061599.1"
                     /locus_tag="CAG99_RS12865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_12855"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_218027911.1"
                     /transl_table=11
                     /translation="MRDVRHPSTGEMTLIAAMSALSDPVRIGLVRLLSDGAERAWGDLR
                     APVAKSTLSHHLRVLRDAGITRSRQEGTRCFVELRRADLDARFPGLLDAVLDAAAREDV
                     GHDVLVASGVAGA"
     gene            complement(19469..19693)
                     /locus_tag="CAG99_RS12870"
                     /old_locus_tag="CAG99_12860"
     CDS             complement(19469..19693)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CAG99_RS12870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CAG99_12860"
                     /product="hypothetical protein"
                     /protein_id="WP_086159486.1"
                     /transl_table=11
                     /translation="MATGSIIFRSTDGRTQVIDEPENGGRFPLAEAGLLENNTDRELRL
                     LPPAGQGDPAMLQPGGSAQIEAGSAVHVI"
     misc_feature    complement(19712..19727)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.75"
                     /tool="antismash"
     gene            complement(19883..21388)
                     /locus_tag="CAG99_RS12875"
                     /old_locus_tag="CAG99_12865"
     CDS             complement(19883..21388)
                     /EC_number="4.1.99.3"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003904 - deoxyribodipyrimidine
                     photo-lyase activity [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018841216.1"
                     /locus_tag="CAG99_RS12875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_12865"
                     /product="deoxyribodipyrimidine photo-lyase"
                     /protein_id="WP_086159488.1"
                     /transl_table=11
                     /translation="MSRDRERAQHEGTKGGGTGGERTSGAKGSGTGGTGSKEAKGGKSA
                     KHEGGKGANGANGARAVSVALFTADLRLRDNPVLHGALRDAPEVVPLFVVDDGVRAAGF
                     RVPNRAAFLADCLADLDAALRERGGRLVVARGDVVAETCRVAAAVGAATVHLAADVSGY
                     AARREERLRVALAADGRRLTVHDGTVTAVPPGAIAPQGKDHFAVFSPYFRRWDAMSLRD
                     VLRAPRTVRVPEVRSARLPTAPGLASGTPSPGLPEGGESAARRRLRAWERGPLDAYADR
                     HDDLAGDATSRLSPYLHFGCVSANELVHRARRHGGAGADAFVRQLAWRDFHHQVLAARP
                     DAAHRDYRDRRSEPWRNTDALAGAVTAWREGRTGFPVVDAAMRQLAHEGWMHNRGRLLV
                     ASFLTKTLNVHWRVGARHFLDLLVDGDLANNQLNWQWVAGTGNDTRPNRVLNPLSQARR
                     FDPRGDYVRRWVPELAGIEGRAVHRPWRLDADLDYPDPIVEPW"
ORIGIN
        1 cgcgatgctg ggcgggcagg cgctgctcgg cgcgttccac gacacgggcc aggtcgccag
       61 gagcgtggac cacgcgttcg gcgcggtggc cctgtccacc gggttcggcg tgacgctgat
      121 cgcggcggtc ggcgccgcct acctgtcggt gcgccgcgcc acacgcggtg ccgcgccggc
      181 cgcgcgcggg cggctgcgga ccgcgggcgg cgtgctcgcg ctggtcgcgg gcgcggggag
      241 cctcgccacc acgttcgcga tggacgcgac cgagcccatg ctcatggcgc ccgccgtgta
      301 cggcgcggtg ctgctgtcgg tcgggttcgc cacgttctcg cccgcgctgc tgcggggcgt
      361 gctgggtgtc atcgggcggc tgctcgggaa gttcggcggg ggcagctacc tcgccgtgca
      421 gaacacgcgg gagcgcgccg ccgaactcgc cggtgtcctc gtgccgctgg tgctgttcac
      481 gggcgtggcg acggcgacgc tgtacatcca gcgcgtcgag agccacgtgc tcgacgcctc
      541 gggcctcgcc aggtcggtgg aggacaagaa cgcggagacg ctgaacctga tcgtcgtcgg
      601 cgtcatcgtg gcgttcgcct gcctgatggt gatcaacagc ctgtacgcgg ccacctcgta
      661 ccggggccgc gagttcggcg ggcagcggct cgccggcgcg acgcgggggc aggtggaacg
      721 catggtgctg atcgagggcc tgatgctgac cgtgaccggg gtcggcctcg gcaccctcgc
      781 gggcctgacc ggcctggcgg cgttcacctc ggtgcgcacc gagacgggac ccgcgcagtc
      841 gccgctgctg tggctcggca tcgccgcgac cgccgcgacc gccgtcctgc tcaccagctg
      901 ggcgacggcc cgcaggacgc tgcgcgttcc cgcggtcgcc gcggtgaccg cagccgcctg
      961 aggaacgcgg cgcgcgttcg aggaacgccg cgcgcgccgc gcccctgacc gccggatgtc
     1021 ccaccgctcc cccgggcggt ggggcatccg gccaactcgt atgtggacgg aacccgttgg
     1081 ggttcgctcg gcgtccttgt cgtgtgtctg tactcacgcc tcagggccag cagggcgcag
     1141 ccgccgggca catgatcgtc agcggggacg acgtactcgc ggtgcggctc ggcgccgaac
     1201 tccacgacgt gtaccgagaa cgcgtcacgc tcatcgtgcc gcccgcgccg ccgtcgggcg
     1261 gctgggcggg gccccgcggg ctggtccggg tgtccgcgct catcgggcgg ctgtcctcgg
     1321 ccgtcgcgcg caacgacccg tcggtgcgcg agatcgaggc ggcggagccg accgaggacg
     1381 tgctgcggca ggcgggcgcc acggaggccg cggcgctggc cctggtgcac gaggacgacg
     1441 agaccaacat caggggcgcg ctggccgccc ggcgcctcaa cccgcggctg cgcctggtga
     1501 tccgcctcta caaccgcaag ctcggccagc gcctggccga actgctcgac caggcggcgg
     1561 acgtgacgct gcctggcctg gacgcggcgg cactcgacgt gtcgaccatt gtgctctccg
     1621 acgccgacac ggccgccccc gcgctcgcgg cctccgcggt cgcgggcacc aggaaggtga
     1681 tcgccgccga cgggctgctg ctgcgcgcgg ccgaacgccc accgcccggt cccggcgaga
     1741 tcgccgaccc gggcctgtgc acgctggcgc tgctctcggc gacggcgcag gacccggcgg
     1801 gcaccgaggg ctccgaccgc agcggcgcgg cggcgccgct gctgctgccc gacgacgcgg
     1861 cggtggcggc ggcgacgggc cgcggcacca tcgtgcttga gaccgtcgcc cacaccgggc
     1921 cgccgctgcc cccgcgccgc ctggcgcggc ggggcgcgcc gctcgccgag gtgttcacgg
     1981 tgcggctgcg gtgggcgctt gccgcggtgg ccgcggcggt gtgcgcgctc gccgtcgcac
     2041 tgtgggcggc cacggacgac cacccgttgc gggccgggta cttgacgctg ctcgacctgt
     2101 tcgccatcgg ggagtcggcc gtcggggaac cggtggcgcg gcagacgatc cagttggtct
     2161 ccggcctggt ggggctcgcg ctgctgccga tcctggtggc gggcgcgctc caggcgctcg
     2221 gcgccttccg cggctccgcc gcgctgcgcc gcccgccgcg cggtctgtcc ggacacgtgg
     2281 tgctgctcgg gctcggcaag atcggcacgc gggtgctcgc gcaactgcgc gacctggaca
     2341 tccctgtggt gtgcgtggag gaggacccgg acgcgcgcgg cgtgccgctg gcgcggcggc
     2401 ttggggtgcc cgtggtcctc ggcgacgtca cgcaggaagg cgtgctcgaa tccgcgaaga
     2461 tcgaacgcgc ctcggcgctg ctcgcggtca ccagctcgga cgcgaccaac ctggaggcgg
     2521 cgctgtgcgc gcgcggcgtg cagccgggcc tgcgggtgtc gttgcgcatc tacgacgacg
     2581 acttcgcgac cgccgtgtac cgcacgctgc gcgcggcgca ccccggcgca ctgacgcgca
     2641 gccgcagcgt gtcgacgctg gcggcgcccg cgttcgccgg ggcgatgatg ggccggcaga
     2701 tcctcggcgc ggtgccggtg gaacggcgcg tgctgctgtt cgcggccctc gacgtggccg
     2761 ggctgccgcg gttcgcgggc cggacggtgg ccgaggcgga ccgggcgggc gcctggcgga
     2821 tcgtcgccct cgacacggcg gagccggcgg accggcaccc cgacctggcg gcgccgcgcc
     2881 cgcgcgagga gaacgccgac gcggccggcc tgctgtggaa cccgcacccc gggtacgtgc
     2941 tgcggcccga ggaccgggtc gtggtggccg ccaccaggct cggcctggcc gaactgctgg
     3001 gccggcggcg ggggccggcg ctctgacggg cggggcgccg gggctccgag gggcggggcg
     3061 cccggggctc cgaggggcgg ggcgcccggg gcgggccgtc aggcagtggc cgggccacga
     3121 ccgccggaac ccacgtatca gcatcaatgt cagtggcggg tgccatgatc gaacggccgg
     3181 ggctcgccgg gccgaccgcg ttcgccggcc cgcggcagtc cacccagccg cccgcactgt
     3241 tcgactcagg ggagaaacgc atgtccgccg acccgttcca gcagcccgcc gcaccgccgc
     3301 gcggccaggc cgcgcccccg ccggaggccg cggccggccc ggtggcggcg gacagccacg
     3361 acgtgatcaa ggtgcgcggc gcccgggaga acaatctgcg ggacgtctcc ctcgacatac
     3421 ccaagcggcg gctgaccgtc ttcacgggcg tctcgggctc cggcaagtcg tccctggtct
     3481 tcggcacgat cgcggccgag tcgcagcggc tgatcaacga gacgtacagc gccttcgtgc
     3541 agggcttcat gcccagcctg ggccgccccg acgtcgacgc gctgcacaac ctgagcgccg
     3601 ccatcgtcgt cgaccaggag cggatggggg ccaactcgcg gtccaccgtg ggcacggtca
     3661 cggacgccta cacgatgctg cgcatcgtct acagccgcct cggcacgccg cacatcggga
     3721 cctcgtccgc gttcagcttc aacagccccg agggcgcgtg ccaggactgc gagggcatgg
     3781 gccaggtgtc gcgcgtcgac atcgatcagc tggtggaccg cgaactgtcg ctcaacgagg
     3841 gcgcgatcac cgtgccagga ttcggggtcg gcacctggta ctggcaggtc atggcgaact
     3901 cgggcctctt cgacaacgac atgaagctga aggactaccc ggccgagctg tgggaggact
     3961 tcctgcacaa gccggccacg aagatcaagg ccggggcgaa caccctcacc tacgagggcc
     4021 tggtcacgaa ggtgaaccgc gtctacctgt ccaaggaccg ggagacgatg cagacgacgc
     4081 tgcgcgcgtt cgtggaccgg gcggtcgtct tcgccgcgtg cccggcctgc cggggcacgc
     4141 ggctgagcgc cgccgcgctg tcctccacga tcaacggggt gaacatcgcg gagtgctccg
     4201 cgatgcagat cagcgacctg gccgagttcg tccgcggcct cgacgcgccc tcggtcgcgc
     4261 ccatgctcgg cgcgctgcgc gacctgctcg gctcgctggt ggagatcggg ctcggctacc
     4321 tctcgctcga ccggccgtcc ggcacgctgt cgggcggcga gtcgcagcgc gtgaagatgg
     4381 tccgccacct cgggtccagc ctcaccgacg tcacgtacgt gttcgacgag cccaccaccg
     4441 gcctgcaccc gcacgacatc cagcggatga acgacctgct gctgcggctg cgcgacaagg
     4501 gcaacacggt gctggtcgtc gagcacaaac ccgaggtcgt cgccatcgcc gaccacgtcg
     4561 tcgacctcgg ccccggcgcc ggcacctcgg gcggcgagat ctgctacgcg ggggacgtgg
     4621 ccgggctgcg cgcgtcgggc accaggaccg gcaggcacct cgcgcaccgg gcggcgctgc
     4681 gcgagacggt gcgcaccccg cgcggacacc tgtcgatcac cggtgccgcc acgcacaacc
     4741 tgcggaacgt ggacgtcgac atacccgtcg gcgtgctgac ggtcgtcacg ggcgtcgcgg
     4801 gctcgggcaa gagctccctc atccacggcg cgctgccggg ccgggacggc gtcgtggtgg
     4861 ccgaccagtc cgccatccgg ggctcgcggc gcagcaaccc ggcgacgtac acggggctgc
     4921 tcgacccgat ccgcaaggcg ttcgccaagg ccaacggcgt gaagccggcg ctgttcagcg
     4981 cgaattcggc gggggcctgc gccaactgca acgggatcgg gctcgtctac accgacctgg
     5041 cgatgatggc cggggtggcc tcggtgtgcg aggagtgcga gggcaagcgg ttcacgcccg
     5101 aggtgctgac gtacacgctc gacggcaagg acatcagcga ggtgcttgaa atgcccgtgg
     5161 cggaggcgca caagttcttc cgcaccgggc aggcgcaggc catcctgggc cgcctgatgg
     5221 acgtgggtct cggctacgtg cggctcggcc agccgctgac gaccctgtcg ggcggcgagc
     5281 ggcagcggct gaagctggcc atccacatgg cggagaaggc ggcgacgtac gtgctggacg
     5341 agccgaccac cggcttgcac ctggccgacg tcgaccagtt gctcgcgctg ctcgaccggc
     5401 tggtggacgc ggggaacacg gtgatcgtca tcgagcacca ccaggcggtc atggcgcacg
     5461 ccgactggct gatcgacatg ggtccgggcg cggggcacga cggcgggcag gtggtgttca
     5521 ccggcacgcc ggccgagctg gtggcgcggg gcgacacgct caccgcgcgg cacctgcgcg
     5581 agtacgtcac gggtacggcg cccgcgaccg gccggtgagc gggggcggcc cggccgggac
     5641 gcccccggcc gggccgccgc gccgcccggt cggcagcatg gccggggcgc gccggggcgg
     5701 ggcggccggg cccggccgga aagacgcgcg ggggaacggg cgttccagtc ggcccggcgg
     5761 tcaccgcgcg gcggcggccg ttcgcgtgat caccgatcgg cggcggacgt tcgcgtggtc
     5821 aggtcgtcgt ccgtgatgtc gcggagcacc cggcacggcg taccgaccgc gaccaccatg
     5881 ggcggcacgt ccttggcgac gacactgccg gcgccgatga ccgagccgta tccgatgcgg
     5941 acgccgggca ggaccacgac gttgctgccg atccacacct tgtcctcgat gacgatcggt
     6001 tcggagaacc gcgcgaagtc cacccggcgc gccgggtgga cggggtgccc ggtcgtggtg
     6061 agcgtcacgc tgggggcggt catgaccccg tggccgatgc ggatctcgac atcgtccacg
     6121 aaggcgagat tgacgttgcc gaagaagtcg tcaccgatgt ggacgttgct gccgaaggcc
     6181 gcactgaacg gcgggtgcag cgcggggcgt tccccgacgg aaccgaggat cgcgcggagc
     6241 agtgagcgcc gcttgtcggc ctcgcccggc ggggtgtggt tgtaggcgaa gatgaggtcg
     6301 gccctgcgcc gctcgtccag gaacaccgcc tccgactcgg tgtagaccag cccgcgcccc
     6361 atgcggtcca gcacgtcccg ctcgtcgtcg cgccccacgt ccgtctcttc ccttcactcg
     6421 cccgtcccgt gccgccgcgt gatcgccggg cggccgggcc ggtcagccgg ccggccgcac
     6481 gtccgccggg agcagtcgct cggtgagcag gcggcgtacg cgaacgtcgc ggtccgcggt
     6541 ggcgagccag gagtcgagca gccgccagcc gtggaagttg cccagaacat acagggccat
     6601 gcccgtggcc cgcagggcgc cgagcgccgc gccggtctcg tcctcggaca gcagggccca
     6661 gcggatgagg tcggcggccg gctcgctgtc cctgcacccc tcggcggccg gccggccagc
     6721 cgtgccgcct gcctcgcgga gcgggcgacc ccttccgggc acgagggcgc cgtgtgacgt
     6781 gaggtcgcgg ggccggggcc acgcgggagg gcgcgcaccg tgccgcccct ggcggtcttg
     6841 ccgcccgaag gggcgccggg cagccttgag attgtcatgg gcacaaccat cagtcgccgt
     6901 cccccggtcg cccgggcccg ttttgaggag ccctcttgcc ccgcagaccc cgcactctcc
     6961 gcagatttcg cacggcccgc agacccggcg cgttccccgt gccgcgcgta tccggcaggt
     7021 cccgcgcggt agccgtcctc accgccgccc tgctgctccc ggccaccgcc gccgccctgc
     7081 ccgccggggc cgccccggcc ggtgccgccc ccgtggggca cgtcctgggc gcgcccgagc
     7141 gggacgcggt cgacggcagc tacctggtcc tgctcgccga cggcggcaag ccggccgccg
     7201 aggcgggcac ccggctggcc gatcgctacg gcgtgcgcgt cgtcgacgcc tacgacgccg
     7261 cgctcaccgg cctccacgtc cacgccaccg cgtcgcaggc ccggcggctg gccgccgacc
     7321 cggccgtccg cgcggtcgag caggacagcg tgctccgcgc cctgccggcc agcacgcagc
     7381 cgaacccgcc caactgtgga ctcgaccgca tcgatcagcc ggacctgccg ctcgacggct
     7441 ccttcaccta cccggactcg gccggcgccg gtgtcaccgc ctacatcgtc gacagcggca
     7501 tcgcctacgg ccacgccgac ttcggcggcc gggccgggcc gggttacgac gccaccgggg
     7561 gcaacggcgc ggacggcaac ggccacggca cctgggtggc cggcctcgtc ggcggcacga
     7621 accacggcgt cgccaagtcc gccgacctcg tgtccgtcaa ggtcctcaac gacgcgggcg
     7681 ccggcaccgt cgccggtgtg gtcgcgggca tcgactggct caccgcggac gcgcggggcg
     7741 ggcccgcggt cgcggtcgtg gccctcggcg gcgtggccag ccaggcgctc gaccaggcgg
     7801 tgcgcgcgtc catcgcctcg ggcgtcacct acgcgatcgc cgcgggcggc agcggtgacg
     7861 acgccggccg ctactccccc ggccgtgtca ccgaggccat caccgcggcg gcgtccgact
     7921 gccgggaccg ggtggcgggg ttcaccaacc acggcccggt cgtggacctg ttcgcgccgg
     7981 gcgtcggcat cgcctcgacc tggccgaacg gcacggccgt gctctcggga acgtcggggt
     8041 ccgccgcgtt caccgcgggc gtcgcggtgc tgtacctcgg tgaccacccg agtgcgtcgc
     8101 ccgcccaggt ggggcaggcc atcgaccagg cggcggccgt cggcaggctg accggcgtac
     8161 cggtcggcag cccgaacaag ctgctccaag tggtcccggt ggactgaacg aaccgcccgc
     8221 ctcccgtggt gccgccgggg caggcgtgag gcacagttgc cccatgcgta cgagtgtgtt
     8281 gcgagccgtg ggtgtggcga cgacggcgta cggggtggcg gtgacggtcc ggcccggcct
     8341 gctcgcgaaa ccgtccgggc tcgcgggtca tgacgggcgg accgccgccg aggtgcgcac
     8401 gtcgctgcgg cccctggggc tgcgcgaggc cgcgtgcggg ctcgcgctgg cgctcgcacc
     8461 ccggggcgcg gcgctgcgca cggccgcggc ggtgcggctg gccgcggact tcggcgacgc
     8521 cgtcctgctg ggcgcgacgt tgccgggccc ggtgcggcgc ggcggcgcgg tcgcggtgtc
     8581 cgtggggtgg ggcgcgctca cgctcgccgg tctgctgctg cccgagagcc cgaacgcccg
     8641 ccgggccgcg gcccgctgac gcctcggccc ggcacccccg accggtccgg cactccggcc
     8701 ggccggccgg ccggtcgccg cgatgcctcc ggtgcccgct gccccagcgg cccggcagca
     8761 caacggcccg gcggcccagc ggcccggcgg cccagcggcc cggcagcccg gcagcccggc
     8821 agcccggcag cccggcagcc cggcagcccg gcagcccggc agcccggcag cccggcagcc
     8881 cggcagcaca acggccggac ggccgacgca gtacctccgg tgccctccga tgcctgcggt
     8941 gcccccggtg cgtgcctgcg gtgcctggtg cccaggcggc gtcgcgcccg cataagtggt
     9001 ggccgcgggg tgcgcggggc ggcagactgc ggtcatggac acctcgcgag gcgacggagc
     9061 cggtcacgcc tggctcggtg ccccgatcga cgcccggccg ctgttcgccc ccgagcacgc
     9121 cgcgttgatg gccctgctgc gcgatctcgc gcccgccgac tggagcaggg aagcggtgcc
     9181 gggctggacc gtgcgggatc tcgccgccca cattctgggc gactgctacg ggcgactcgc
     9241 ccgcgcccgc gacggacacc ggggagggcc ggcgcccgaa ccgggcgaga cgcttgagac
     9301 gttcatccac cgcgtcaacg ccgagtgggt ggccgcgttc tcccgggtga gcccggccgc
     9361 gctcaccgac accctggacc tggtgggcgg gcagaccgtc cggtacttcg aggccgccga
     9421 cctcgactcc ccgtcgctcg gcgtgtcctg ggccggagcc gacccggcgc cgatgtggct
     9481 ggacagcgcc cgtgaactca ccgagttctg gacgcaccgc cagcagatcc ggcacgccgc
     9541 cgggcggggc acggaccccg acccacggct gtggtccgtg gtcctcgaca cctttctgcg
     9601 tgcccttccg cacacgctgc gcgcggtcga cgcgccggtc ggcacccagc tccgcgtgcg
     9661 gatcgacggc ccggccggcg gcacgtggac cgccaccgcg acgggcgagc gctggtcgct
     9721 cgccccgccc gcgggcgaac gcccggccgc gaccttggag ttggaccccg agaccgcctg
     9781 gcgcctgtgc acccgcggca tcgcaccgga cgacgccctc accctggccc gcctgcacgg
     9841 cgaccgcgac ctggcggcgg ctgcctgccg gatcgtgtcc atcgtccatt gaccggctcc
     9901 gtgtcaccgc cgccccgcgt ccaacaccac cggcccggcc gataccaccg gcatgaccaa
     9961 cgcgcccggc acgaccggca ccaccaaccc gaccggccgc ctacgacgcc cgacgcgccg
    10021 cgggcggacc gagcaggcgg gtgatcctgg ccgccgaggt gcccaggccc gtcggcgcac
    10081 ccagcggcca caacgcgccc tgcgcgtgcc tgcgcaggtc gctctcgcgg taacggcggc
    10141 agaaccggtg ccagttcagg atgccggcca gccagttctc caggtcgcgg acgtaaccgt
    10201 cgaggatgcc ccgcacctcg tcgtcgagcc cgaagtcctc gtacagcacc gggagctcgt
    10261 gtgccgcgac gtgctggaac tgccgcatgc gctcggccat caggtccgcg atcacgcgca
    10321 gcgccgccgg gtagtcgcag tcgaagaagt cctgcaccac cagcacgccg ttgtggatct
    10381 ccccctcgaa ctcgatctcc ttctggtacg agaacacgtc gttcatcagg caggcgtagt
    10441 cggccgccgc gttctccagt gagctgatcg ggccgctgcg gtagacctcc tgcggcacct
    10501 tcgggccgtg cccgagcctg gccaggcaca tcgtcaggtc ggaaccgaac gtctgccggc
    10561 gcatctcgac gtagtcgacg ggctcgggaa tgcggttctg cgcctggttg tccagctccc
    10621 agacccagct cgccgtcatc acctcgatcg tctcgcggaa cctgcgccgc gcgggcagcg
    10681 tcatcggccc cgcggtgcgc ggccacaggt ccgcgaggcc gcgttccagg ccggagacgg
    10741 gaaccggcat cgcgtccggg tcctcgacgg gcatgaactg cgcgatccgc tcggtcacgg
    10801 cccgcgcgcc cgccacgtcg tgagtgcggc cgaagaggac cgggtacagg tcgtcgccgt
    10861 acgtgcccca cgccagccag cccgagacca cgtcgagcgc gtcggccggt gcgtcggggg
    10921 caaggcccgc ggcgcacagc ggcaggtcgt agtcgtacag cttggcctcg gtccacggcg
    10981 caccgtcgag gatgccgacc cggtgcgccc acgcggccag gcgcgtccgc gcgccgtcga
    11041 ggtgcacgtt gagccgcagg tcgaacggca tggggaagtc cggcagcagc gagggcccga
    11101 cgcgccggtg cggcacgtgt cggaaccgcc tggccctggc cgcctccgcc ctgcgggtgg
    11161 tcgtcacgcc gccggggccg cgccgcgcgc cgcccggcgc gcgcagggcc gcggtgccga
    11221 gtcccggcgg cagcccgggc aggaccggca gcgcagcgag gccgggcgcg ggcgcgtgcg
    11281 ccgcgccgcc gccggccgct ccgttcatgt accggctgga gcgcatgtgc cactcgtggc
    11341 cgcccgactg ccagtcctga agtcccttgg cgtaggcgag gacggcggcg caggacgcgg
    11401 cgtcgagccc ggactccgcg aacagcgggc caagttcggt cacgcaggtg tgctcgaact
    11461 gctggaggcg cgcggtcagc aggtcgttga cggcctcggc ggcctcctgc gtcgagcagg
    11521 cgaggaacgt ctccagcacg aggacgccgt tgctcatctc gccctcgtcc tcgatctccc
    11581 gctggtagga gaacaggtcg ttgcgcaggt ggacgccgtc ggagaaggtg tcgcgcagca
    11641 cgcgcaacgg ccggctcgcc gcgacggccg cgggcacttc ggcgcgcgcc gcgtactcga
    11701 cgagacccgc cgaccagggc gcgccgccga ccttgcggcg catctcgatg tactcgacgg
    11761 ggttgggcac gcggccggcg ttgatgttgg acagctccca cagcgactcg ttcagcaggt
    11821 tggcggtgct ctcggcgaac ctgcgccgcc acgcgggcga catggccggc accgtcctgg
    11881 cccacaggtc ggcgagcccg gcctccaccg ggttcgtcgg ctcgggggtg cccgcggccg
    11941 ggtcgagcgg catgaacgcg ggcagccggt cgaggtacgc cttgccgccc ggccggtcct
    12001 gcgtgcgctt gaaggtctca aggaagtggt cgtcgaagaa gaagacccac acgtaccagt
    12061 cggtcaccag gcacaggtcg tcggccgagg cgtccgggtg cgtgtacgcg cacagcagcg
    12121 ggtagtcgtg cgcgtcgagg tcggcgccgg tccagatccc ggagctctcc agcatcccca
    12181 tgcgtgcggc ccagcgcggc gagtgctccc tggccgcgtc gaggtggggg ttgagccgcg
    12241 cgggatacgg catgtagaac gcgggcagtt cgaagggctg tgtcatggcg cgtctcccgg
    12301 catcgcgtgg cacccgaatg gcccacagca ttgcccgtac ctcgacccac cgccggacaa
    12361 tcagaacaat tcgcacccca attcgctggt tcgagtgaac catgcgacgc gtgcgcggtc
    12421 gcgctgcgta ccgacgcgaa ctcttgacgg cggacccacc ccctcatact gtcgcgccga
    12481 cccgctttga aacgtctcat tgaaacgact caatccactt tcatcccctt tcgacgcgcc
    12541 cgtccagcgc gccaccgcac ccgaccaagc acctcaagac cggcctcgcg cggcaggccg
    12601 aaggctcccg cgcgacaggc aagaagggcg tcacccgatg acaccagcgg acagacgacg
    12661 tagggccagg aaccggcggt tgatcgccgc cccgctcgcc ggcctgatga ccgcgggcct
    12721 gctcgccgcg gcgggcaccg ggcccgcccg ggccgcggcg ccggccgcgc aaccagcggc
    12781 ggaaccggcc gcgcgcggcg ccgaacgccc cgcgcccggc ggcgtccagc tcgaacacct
    12841 cgaccgcggc ctggccgcgg tcgccaccgg ggaaggcgtg ttcctcagct ggcggctgct
    12901 ggccaccgag gtcaccggac actcggaaac cggcctgacc ggcgccgact tccacgtgta
    12961 ccgcgacggc gaactgctcg gcaccgtcac cgactcgacc aactacctcg acgccgaggc
    13021 gcccgcgggc gccgagtacc gcgtggccgc cgtcgtcgac ggcgtcgagg tcgacctgag
    13081 cgagcccgtc tccccctggt ccgacggcta ctacgaactg ccgctgaaca agcctgccga
    13141 cggcgtcacc ccggccggcg aggcgtacac ctactcggcg aacgacgtca gcgtcggcga
    13201 cgtggacggc gacggccagt acgagtacgt cgtcaagtgg tacccgtcga acgccaagga
    13261 cgtctcccag gtcggctaca ccggcaacgt ctacctcgac acctaccgcc tcgacggcac
    13321 cctgctgcac cgcgtcgacc tcggcgtgaa catccgcgcc ggcgcccact acacccagtt
    13381 cctcgtgcac gacttcgacg gcgacggccg ctcggagatc atgttcaaga ccgcgccggg
    13441 caccaaggtc acccgctacc acccggacgg ccgcgtcgcc tcggagcgcc acatcacgat
    13501 gccgcgcgag gacatccgcg ccgggtacgg gcacgacgac gactaccgga tgagcgcgga
    13561 ggactactac gcgcacgtcg tcggcatgtt cgaggactgg cacgagcacc ccgaggtggt
    13621 ggcgggcaac tggcccgcga cgcttgagga ggcgttcggc atcgcgcccg cccacgacta
    13681 cccgttgtcc cgcgaggacg ccgaggcgct ggccgaccac ttcatagacg cgtacgcgcc
    13741 ctcccgcagc gcgcgcaaca acctgcgcgc gttcgagggc ttcatcctcg aagggcccga
    13801 atacctcagc gtgttcgacg gcgcgaccgg ccgcgagctc gacacggtcc gctacgagcc
    13861 gggccgccac gacgacggcc tgatgtgggg cgactacgcc atggcccgca tcgagcctgg
    13921 caaccgcgtg gaccgcttcc tgtcgaccgt cgcctacgtc gacgggcagc acccctcggc
    13981 cgtgttcgcg cgcggctact acacgcgctc cacgctggtg tcctaccgct gggacgggca
    14041 ccggctgcgt gaggactgga acgtcgacag cggctggacc ccgatgtcca acccgttcaa
    14101 cgacggcccg cacggcgtcg acggcaccga ccccgagttc ggcacgctga ccacgcaggg
    14161 cttccactcg ctcagcgcgg ccgacgtcga cggcgacggc cggcaggaga tcgtctacgg
    14221 gtccgcgacc atcgacgacg acggcagcct gctgtacagc tcgttcgccg agatgccgcc
    14281 cggcagcgcc gaccccggcg cgcaggcccg cctcggccac ggcgacgcga tgcacgtcac
    14341 cgacatcgac ccggcgcggc cgggacttga gatctacacc gtgcacgagg gcggcgcgag
    14401 cgcgccgctc ggctacgcgc tgcgcgacgc cgccaccggc gaggtcatct acggcgagta
    14461 caccggcgtc gacaccgggc gcggcatgat cggcgacgtc gacccggacg agccgggcct
    14521 cgaaacgtgg gccaaccacc ccgagggcgg cagcgacccc gacggcgtcg gcctgtggac
    14581 cgccgacggc cggcggctcg gggagcggac gcccggcacg aaccagagca tccgctgggc
    14641 gggcgacctg acgacgcaga tcgtggccgg ttacgggtat ctcggtcagg acacggtcat
    14701 cgaggactgg cggcgcggca cgctgctgac ggccgagggc accaggacga acaaccacac
    14761 caagggcaac ccggccctgg tcgccgacgt cctgggcgac tggcgcgagg aactgctcgt
    14821 gcccacggcg gacagcaccg gcctgcggct gtacgtcagc accgaactca ccgggcacaa
    14881 gctgtacacc ctgatgcacg acccgcagta ccgggccgag gtggcacggc agcagacgac
    14941 gtacaaccag ccgtcctaca ccggcttcta cctggcctcg gacatggact tctcccaggt
    15001 tcccgtgccc gacctgtgga ccccgggcgg ggtggccgcg ctggccgacg acctggcccg
    15061 tcgcgtggcg gacggtgagg tgtcgttcct gtccgggctg ctgctgaagc cgtggacggt
    15121 gcaggccgaa ctgcacatgg cgcgcggcga ccacgcctcg gcggcgaggg cgctggaacg
    15181 gttcaccgcg aagctcgaac acctgcgcgg cgtctcggac ccggcccgcg cggcgctcac
    15241 ccaccgcgcc gagacgctga tccgcacgct gcgctgatcc gcacgccgcg ctgacccgcg
    15301 cggcgagcgg cctcccgccc cgcccccgga cccgaacgga ccggcccacc gcctccgttc
    15361 gggtccgctc cgggcgcggc gcgcgccgcc tgggcggccg tggcgggcgg tggtggtggg
    15421 gtgggaggct cccgtcccgg aggtcgccat ggaacccctc gccgtcctgg tcgtgggcta
    15481 cgcggtggtc cgcctcgccg gtctgctggg cgtcgacgtc gtcgacggct ggcagccggc
    15541 cctgcgggtc gcgctggccc tgatgttcct gttcaccgcc gccagccact tccatcccag
    15601 gacgcggccc gccctgatcg ggatggtccc gccgtccctg ccccggcgcg aacgcctggt
    15661 cgacctgacc gggatgctgc aactggccgg cgcgatcggc ctgctggttc cggccacgcg
    15721 gcgtctcgcg gcggtggggc tgctcctgct cctggtcgcc atgtttcccg ccaacgtgtc
    15781 cgcggcccgg cgcgcggtcg cgcagggcga cccgctcggc ccgcgcaccg cgatccagct
    15841 ggtgttcatc gccgcggtgg ccctcaccct gctctgagcc gtgccacgcg ggtgtgccgt
    15901 cccgggcgtt ccacggcgtc gccgtccccg cggggacggc gaattccgat gcgtggccgc
    15961 aggcggtctg cgatcctcgc cgcatgcgca ccgcaagtcc cgggagcccc gggaacctca
    16021 tgtctcccga catagcagcc aggttcgatg aactcgtcgc cgagggcgag gccgttccga
    16081 cggagggctg ggacttctcg tggttcgcgg ggcgggccac ggaggaacgc cctgcctggg
    16141 gctactcgtc gctgctcgcg gaccggatgc gggcggcgga ggcggcgctc gacatgcaga
    16201 cgggcggcgg cgaggtactg gccgccgtcc ccgtgctgcc tccggtgctc gcggccacgg
    16261 agtcgtggcc gccgaacgtg gggatcgccc gccggaagct ggcccccttc ggggcgaccg
    16321 tcgtcgccat ggaggacgac gcggcggatc tgccgttccc cgacgggcac ttcgacctgg
    16381 tggtcagccg gcacccggtg gtgacgcggt gggacgaggt gcgcagggtg ctgcggccgg
    16441 gcggcaccta cctggcgcag cacgtggggg cgggcagcgt gcgggagttg acggagttca
    16501 tgatggggcc gaaccccttc ccgccgcccc cgccggcccg gccgttcacg accaggtcgg
    16561 gcgcgacgcc gacgggcgcc gtggccgtcg cggagtcggc ggggctcgtc gtcgtggacg
    16621 tgcggcagca ggcgttgcgc atggagttcc acgacatcgc ggccgtggtg cacttcctgc
    16681 gcaaggtgat ctggaccgtg ccgggcttca ccgtggacgc gtaccgggag cgcctcgcgg
    16741 agctgcacga cttcatcgaa cggcacggcc cgttcgtcgc gcacgcgcag cgcttcctca
    16801 tcgaggcgcg caggccctga cggggcgccc ggcgggcgcc gggcgtcagc gggccgtgca
    16861 ccaggtgacc agcacgccgt tgtcgaacgt ctcgcgtgcg gtgggcgtga acagcgtggg
    16921 atcgaacgcc ccgtcgaaca ccgaggggcc ggccccggcg acgaccgggt agctcttgat
    16981 gatcaactcg tcgatctccg gaagcagttc cccggcgagt cggccgccgc cgcagagcca
    17041 gatgtccagg ccgccgtcct cctgtttgag ccggcggacg aggccgagcg gatcggaggg
    17101 gaccacggtg acgtccgggt ccgtgccggc gtcgagggtg cgcgagacga cgtactgccg
    17161 caggtgggcg tagggactgg tgacgcccgc gtccagcgcg ggcaggtagg tgccgcggcc
    17221 catcacgacc gtgtcgcagc ggcggttggg gacgccggcc aggccgaaca tctcccgccc
    17281 cgcggtcggc aggaactcgg ggtagcgcgc gttcatccgc tccgcgtagc cggcggcctg
    17341 ctcctcgtcc ccgagcggga agaagtcgta ctcgccgccg ggcccggcga tgcggccgtc
    17401 gagggtgacg gcgatgtagt agacgagctt gcgcatataa ccactccagg cgtagtactc
    17461 tgtgaccggt gagaacgtag tactacaact ggagtggtgt caaatggtcc ggcggaacga
    17521 cgaacggcgg gcggcgctgc tggacgccgc gatcgaggta ctggcgcagg aaggggcgcg
    17581 cggcctcacc ttccgcgccg tcgacaccgg cgccggggtg ccgaagggca cggcctcgaa
    17641 ctacttcgcc aaccgcgacg agctgttcac gcaggtgggc gagcgcttct acgaacgcct
    17701 ccagccggac gaggccgcca tggcccgcat gcgggacgcg ccgcgcgacc gggacacgta
    17761 cgtgacgctg atgcgcgaac tggtcggccg cgtcagcgcg ttccgcaccg gctacctggc
    17821 cctgctcgaa ctccgcctgg aggccacccg gcgcccgcgc ctgcgcgagg tcctcaccgc
    17881 gcgcgtccgc gcggacgccg acgccaacgt cgcataccac gaggcatcgg ggctgccggg
    17941 ggacgcgacc gccgtccggc tcctgatgct gacgctgaac tggctcatcc tcgaacagct
    18001 cacgctgccc gacctgttct ccgaggacga gcgcgaacgc ctggtgcagg ccgccgtcga
    18061 gcgcatcgtg ctgccctgac ccggggcgtt cgcgaggccg ggcgtccttc gggcagggcc
    18121 gggacgggcg gcgttcgcgg ggccgggcgt tcctcgggca gggcgttcct cgggcagggc
    18181 cgggcggcgt tcgtcaggtc aggttgaggc cgccgtcgac ggcgaggacc tggccggtga
    18241 gccacgtggc ggccggatcg gcgaggtgga gcagccacgc ggcgacctcc tcgggctcgc
    18301 cgcgccggcc gagcgggatg cgggcggtct cctccgcctt gaccgccgcg atgacctcct
    18361 ccggcagccc ggcggcgtgc agcgcctcgc tctcggtcgg tcccggcgcc agggcgttga
    18421 cgcgaatgcc ctcggcggcc agttcgaggg cccaggagcg cgtgagctgt tcgagcgcgc
    18481 tcttggaggc cgcgtagtgg gacaccccgg cacccggccg gtgaccgtag gtgctggaga
    18541 cgttgagtat cgagccgcgc gtctcccgca ggtgcggcag ggcggcgcgg gcgaggaggc
    18601 tgggggcgat cacgttcagg tcgaacatcc gcgccacccg ctcggccgtc acctcgggca
    18661 gggtcatggc gtccatgccg cccgcgttgt tgaccaggac atcgatccgg ccccagcggt
    18721 cgaccgccgc gccgacgacc gcctccgccg cgccgggggc gcggatgtcc gccgggaagg
    18781 cgacgacgcc ggggtgggcg cgggcggttt cctccagcgg cccgggccgg cggccgacgc
    18841 cgagcacatg ggccccctcg gccgcgaggg caagggcggc ggcccggccg atgccggacc
    18901 ccgcgcccgt gacgatcgtg acgcgctggt ggaaccggcc gggggccggg gagtgctggg
    18961 acaaggcgtc gcccttcgtt cgatgttcga cgaacataga acgaacgtat catcgttccc
    19021 atgcgagacg tgcggcaccc gagcaccggc gagatgacgc tgatcgcggc gatgtccgcg
    19081 ctgagcgacc cggtcaggat cgggctcgtc cgcctgctgt cggacggcgc ggaacgggcc
    19141 tggggcgacc tgcgcgcgcc cgtggccaag tccacgctca gccaccacct gcgggtgctg
    19201 cgcgacgcgg gcatcacgcg cagccggcag gagggcacgc ggtgcttcgt cgaactgcgc
    19261 cgcgccgacc tcgacgcccg gttccccggg ctgctcgacg cggtgctcga cgctgccgcc
    19321 cgggaggacg tcgggcacga cgtgctcgtg gcctcgggcg tggccggggc gtagccggcg
    19381 ggcgccctgc gggccggggc gcgtccggcg gtgggcggcg gggcatgggc gtccggcggg
    19441 cccgcggtcc cggcgcgggc cgccgggctc agatcacgtg gacggccgag cccgcctcga
    19501 tctgcgcgct gccgcctggc tggagcatgg cggggtcccc ctgcccggcc ggcgggagga
    19561 gccgcagttc gcggtccgtg ttgttctcca gcagcccggc ctccgcgagc gggaaccggc
    19621 cgccgttctc cggctcgtcg atgacctgcg tccggccatc ggtggacctg aagatgatcg
    19681 aacccgtcgc catggggacc tccggcggtg cgtgggaaaa gcgggaaccg cagacatgcc
    19741 acgccgcgcc ccccgcgagg cccgccgggc caggacacca cccgggggga gcagcgcgac
    19801 ggcgccgccc ggacccaccg gggtcgcggc ctcacccgag ccacggcctc acccgagcca
    19861 cggcctcacc ggggtcaggg cctcaccagg gctcgacgat cgggtccggg tagtcgaggt
    19921 ccgcgtccag ccgccacggg cggtgcacgg cccggccctc gatgccggcc agctccggca
    19981 cccaccggcg cacgtagtcc ccgcgcgggt cgaaacggcg ggcctggctc aacgggttca
    20041 gcacccggtt ggggcgcgtg tcgttgcccg tgcccgcaac ccactgccag ttcagctggt
    20101 tgttcgccag atcgccgtcc acgagcaggt cgaggaagtg ccgcgccccc acccgccagt
    20161 gcacgttcag cgtcttggtc aggaagctcg ccacgagcag ccggccgcgg ttgtgcatcc
    20221 agccctcgtg cgcgagttgc cgcatcgccg cgtccacgac ggggaaaccg gtcctgccct
    20281 cgcgccacgc cgtgacggca cccgcgaggg cgtcggtgtt ccgccacggc tcgctccgcc
    20341 ggtcgcggta gtcgcggtgc gcggcgtccg ggcgggcggc gagcacctgg tggtggaagt
    20401 cgcgccaggc cagttgccgg acgaacgcgt ccgcgcccgc gccgccgtgc cgccgggcgc
    20461 ggtgcacgag ttcgttcgcg gagacgcagc cgaagtgcag atagggcgaa agacgcgagg
    20521 tggcgtcccc cgccaggtcg tcgtgccggt ccgcgtacgc gtccagcggt ccgcgctccc
    20581 acgcgcgcag ccgccgccgc gccgcggact cgccgccctc cggcaggccc ggcgacggcg
    20641 tgcccgacgc caggcccggg gccgtgggca ggcgcgcgga ccgcacctcg ggcacgcgca
    20701 ccgtgcgcgg cgcgcgcagc acgtcgcgca gcgacatggc gtcccagcgc ctgaagtacg
    20761 gcgagaacac cgcgaagtgg tccttgccct gcggcgcgat cgcgccgggc ggcacggccg
    20821 tgaccgtccc gtcgtgcacg gtcagccgcc gcccgtcggc ggcgagcgcg acccgcagcc
    20881 gctcctcgcg gcgcgccgcg tagccgctga cgtcggcggc gaggtgcacc gtcgccgcgc
    20941 cgacggccgc cgcgacgcgg cacgtctcgg cgacgacgtc gccgcgcgcg acgacgagcc
    21001 ggccgccgcg ctcgcgcagc gcggcgtcga ggtcggccag gcagtcggcg aggaacgccg
    21061 cccggttggg cacgcggaac ccggccgcgc gcaccccgtc gtcgacgacg aaaagcggca
    21121 ccacctcggg ggcgtcccgc agcgcgccgt gcagcaccgg gttgtcgcgc aggcgcaggt
    21181 cggcggtgaa cagcgcgacg gacacggccc gcgcgccgtt cgcgccgtta gcgcccttgc
    21241 caccctcgtg tttcgcgctc ttgccgccct tcgcctcttt actgcccgtg ccgcccgtgc
    21301 cgctgccctt ggcaccgctg gtgcgctcgc cgcccgtgcc gccgcccttg gtgccctcgt
    21361 gctgcgcacg ttcgcggtcc cggctcatcg cggtctcagc cctccgcctg cgcggtgctc
    21421 gtgatggtgc ggaccatgcc cccgaacacc caggcgtgga acggggccac cgcccaccag
    21481 tagacgtgcc ccgccaggcc gcgcgggtgg aacagggccc gctgacggta cagcgtgcgg
    21541 ccctcgtcgt cccggtcgac acacagctca agccacgcgg tgcccggcac gcgcatctcg
    21601 ccgcgcagcc gcagcaggcg ttcgggttcg agcgcttcca cgcgccagaa gtcgagcgcg
    21661 tcgccgaccc gcaggcgcgc cgcgtcgcgc ctgccgcggc gcagaccgcc gccgcccacg
    21721 aggctgtcga gccagccgcg cacggcccag gccaccggcg aggaatacca gccgttctcg
    21781 ccgccgatcc cctcgacgac gcgccacagc gcctccggcg aggtgtcgac ggcgcgctcg
    21841 cgccggtcgg tgtagaggct gccgcccgcc cacgccgggt cgctcggcaa cggccccgcc
    21901 gccgcgtcgg ccggggcgcg gccgcctgcg cggtcgcccg cgcggtccgg ggacccgccc
    21961 ggaacgggct cccgctcgcg ttcccgcacc cgctcgcgtt ccccgtcccg ttccccgctc
    22021 agcgcgcggg cgcggtcgcg ggagaggtcg ggggtggggc ccgaggtggt gtcgagggct
    22081 gcgtcgagtg cggcgtccag gccgagcggg gcgccgggcg gcgggggcac gtaccgttcg
    22141 atgtcccgtt cgcggcacac gacttcgtgg cgcaacgact ccaccagcgg gcgggccagc
    22201 cggccgggca gcggggtgac gagaccgacc cacaggctgg acaggccggg cgtgagcacc
    22261 ggcaccggaa cgatcagccg tctgcg
//
