LOCUS       NZ_CP021121            21194 bp    DNA     linear   CON 31-JUL-2024
DEFINITION  Streptomyces marincola strain SCSIO 03032 chromosome, complete
            genome.
ACCESSION   NZ_CP021121
VERSION     NZ_CP021121.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces marincola
  ORGANISM  Streptomyces marincola
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6287975)
  AUTHORS   Ma,L., Zhu,Y., Zhang,W., Zhang,G., Tian,X., Zhang,S. and Zhang,C.
  TITLE     Complete genome sequence of Streptomyces sp. SCSIO 03032 revealed
            the diverse biosynthetic pathways for its bioactive secondary
            metabolites
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6287975)
  AUTHORS   Ma,L., Zhu,Y., Zhang,W., Zhang,G., Tian,X., Zhang,S. and Zhang,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2017) Key Laboratory of Tropical Marine
            Bio-resources and Ecology, South China Sea Institute of Oceanology,
            164 West Xingang Rd., Guangzhou, Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method :: Hierarchical Genome Assembly Process v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 165.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002128305.1-RS_2024_07_31
            Annotation Date                   :: 07/31/2024 06:55:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,513
            CDSs (total)                      :: 5,438
            Genes (coding)                    :: 5,343
            CDSs (with protein)               :: 5,343
            Genes (RNA)                       :: 75
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 95
            CDSs (without protein)            :: 95
            Pseudo Genes (ambiguous residues) :: 0 of 95
            Pseudo Genes (frameshifted)       :: 19 of 95
            Pseudo Genes (incomplete)         :: 88 of 95
            Pseudo Genes (internal stop)      :: 2 of 95
            Pseudo Genes (multiple problems)  :: 13 of 95
            CRISPR Arrays                     :: 12
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:29:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1687697
            Orig. end                         :: 1708891
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP021121.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Key Laboratory of Tropical
            Marine Bio-resources and Ecology.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21194
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="7"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..21194
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21194
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11194](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11194
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    233..248
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.83"
                     /tool="antismash"
     misc_feature    1100..1115
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.35"
                     /tool="antismash"
     misc_feature    complement(1324..1337)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.91"
                     /tool="antismash"
     gene            1338..3011
                     /locus_tag="CAG99_RS07125"
                     /old_locus_tag="CAG99_07130"
     CDS             1338..3011
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025: diguanylate cyclase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005317188.1"
                     /locus_tag="CAG99_RS07125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_07130"
                     /product="bifunctional diguanylate
                     cyclase/phosphodiesterase"
                     /protein_id="WP_255308398.1"
                     /transl_table=11
                     /translation="MLRDYRAAFQIAQFPMALVGAAGQILAANAAFGLLLGVEPERLAG
                     VRADAVAGLGLDGRTRGSYHAVLRGHSDHLRCTRRLKHADGHSLWAEVTVLPTPTESSA
                     ALLTVLDISERRALQERLRHIQMHDPVTRLPNRALFFERLTAALSDSATGRIGLCQVGI
                     DGFKAVNDTLGHRVGDELLGAAGQRLAECATGAGGHLVARLGGDEFAVLVEGSTGTEQL
                     TELAETMLAALQRPFDLAGQRLAVSASIGVVERESATTTATGLMQAADTTLYWAKADGK
                     ARWTLFDPERNAHRMTRQSLSSTLRRGVDRGEFTLEYQPIVGLADDIVRGAEALVRWRH
                     PQFGTLGPDRFIGLAEENGAIVPLGRWILGEACRQARRWQVEHPGPPLFVSVNVAVRQV
                     WDSDLVSDVAKALDDSGLPSGLLQLELTESAVMGSAGRPLQALQALADMGVRIAIDDFG
                     TGYSNLAYLSRLPVRALKLDGMFVRGFRTARHLNPADETIVSSLVQLAHKLGLTVTAEC
                     VEGPAQAERLRRIGCDTGQGWHYARPMSPDHLADLLAGRD"
     gene            3149..3502
                     /locus_tag="CAG99_RS07130"
                     /old_locus_tag="CAG99_07135"
     CDS             3149..3502
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CAG99_RS07130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CAG99_07135"
                     /product="hypothetical protein"
                     /protein_id="WP_159029767.1"
                     /transl_table=11
                     /translation="MAESIPLDRFLRLLADESVPVVHRALWALLWESDVRVLDLLALEV
                     ADESRIRPQAGGALGGQAETLLARLVAGRTSGPLFAVGGRTLSWDEAVRTAGAAGVPIH
                     AFRTSGRQHRGAL"
     gene            complement(3639..4391)
                     /locus_tag="CAG99_RS07135"
                     /old_locus_tag="CAG99_07140"
     CDS             complement(3639..4391)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018542216.1"
                     /locus_tag="CAG99_RS07135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_07140"
                     /product="aspartate/glutamate racemase family protein"
                     /protein_id="WP_086158169.1"
                     /transl_table=11
                     /translation="MAATVGFLYPGHSAEDDFPRMERLLNDAGAGVLLPLVHTDIGTDA
                     HRVDALLEMGSVDRLTAGLDEVAARGAQAVVWACTSASFVFGWDGAADQVRRLAAHAGL
                     PASSTSFAFARAARAMGVTRVAVAATYPDDVAGLFGDFLKAAGVEVTGVRGSGIITAAE
                     VGTWGREEVLRLLREGDDPAADAVLLPDTALHTAAWLPELEAAAGKPVLTANQVTAWEG
                     LRLLGHTPVCPALGGLFAAPRPVRAGES"
     gene            complement(4399..5226)
                     /locus_tag="CAG99_RS07140"
                     /old_locus_tag="CAG99_07145"
     CDS             complement(4399..5226)
                     /GO_function="GO:0036361 - racemase activity, acting on
                     amino acids and derivatives [Evidence IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019357060.1"
                     /locus_tag="CAG99_RS07140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_07145"
                     /product="aspartate/glutamate racemase family protein"
                     /protein_id="WP_107485754.1"
                     /transl_table=11
                     /translation="MDVSFLGGPLPQRGIGVVAPFDFALDRELWRWVPDDVSLHLTRTP
                     FVPVEVSLDLARLVSEHETLREAVRALSAVSPEVVAYACTSGSFVGGVVGERAMSAAMR
                     QAGELPALTTSGALLGALNELGARRVAVVTPYTKSVTDSLEDYLREAGIQVCGRSYLGL
                     TREIWRVAYRDVVAMAREAVAEGPEALFISCTNLPTYDVIPQLEAELRMPVISANQVTM
                     WSALRSIGKEAVGPYQALLDPVARQGPASMTSEAGGQEVAPAVPPPAFPDEEG"
     gene            5382..6350
                     /locus_tag="CAG99_RS07145"
                     /old_locus_tag="CAG99_07150"
     CDS             5382..6350
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574268.1"
                     /locus_tag="CAG99_RS07145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_07150"
                     /product="D-2-hydroxyacid dehydrogenase"
                     /protein_id="WP_086158170.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 2.5e-47, bitscore:
                     158.8, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEARVLVLDAQPPPRLDRLAGRARVLHSDESSLHGLLPEADVLL
                     VWDFTSDAVRAAWPGPGPRPRWVHTASAGVDRLLFPELLESDAVVTNARGVFDRPIAEY
                     VAGLVLAMAKDFRRSLEFQRAHRWQHRETDKVFGSRAVVVGSGPIGRRIGTTLGALGVT
                     VRLVGRTARAADPDFGRVHAGEELPALLPDADWVVCAAPLTPRTTGMFDAAAFALMKPT
                     ARFINVGRGAHVVQDDLVAALRAGRIAGAALDVFATEPLPATSPLWDLPDLIISPHMCG
                     DTHGWRDDLADQFLDNFDRWVAGEPLANVVDKHLGYVPAEG"
     gene            6350..7789
                     /locus_tag="CAG99_RS07150"
                     /old_locus_tag="CAG99_07155"
     CDS             6350..7789
                     /EC_number="3.5.1.4"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1105: amidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019357058.1"
                     /locus_tag="CAG99_RS07150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_07155"
                     /product="amidase"
                     /protein_id="WP_086158171.1"
                     /transl_table=11
                     /translation="MTDLCSLTALELTARYAAGDLSPVEVAEAALARADAIQPVVNPFV
                     FTDPEGALAQARAAEERWARGAPAGPVDGVPVTVKDILLQRGHPTRRGSAALPAGPGPW
                     EEDAPAVARLRESGAVFLGKTTTPEFGWKGVTDAPLSGATGNPYAPERTSGGSSGGSAA
                     AVALGAGPLSLGTDGGGSVRIPAAFCGVFALKPTYGRVPLYPASAFGTLAHVGPMTRDA
                     ADATLLLDVIAHPDARDWSHLAPGGVPFTEALVPGAEGLAGLRVAWSPTMGGVVVAPDV
                     AAVTRDAVERLAALGAEVTETDPPLPPLPRVRAAFQTLWFSGAARVTQHFDEAQRAAMD
                     PGLREVVSAGARFGALDYLEAVDLRMEMGRQMGAFHEEFDLLVTPTLPITAFGRGVEVP
                     DGSGLTRWTEWTPFTYPFNMTQQPAASVPCGTGADGLPVGLHLIGARHADALVLRAAHA
                     LYETGVAGVPAPALAASAPGA"
     gene            complement(7861..8370)
                     /locus_tag="CAG99_RS07155"
                     /old_locus_tag="CAG99_07160"
     CDS             complement(7861..8370)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060960.1"
                     /locus_tag="CAG99_RS07155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_07160"
                     /product="DUF3830 family protein"
                     /protein_id="WP_086158172.1"
                     /transl_table=11
                     /translation="MTNADDRFITVSLDKRGVSCTARLLSDRAPITCDAVWNALPLGGD
                     VYHAKYARNEIYALVPPFAPQEPPLENPTVTPIPGDLCYFTFSDTQLGTSSYGYEDDAK
                     HQGRTTVVDLALFYERNNLLINGDAGWVPGIVWGTVVDGLDRMADACQDLWRAGALGES
                     LNFRRA"
     gene            complement(8446..9144)
                     /locus_tag="CAG99_RS07160"
                     /old_locus_tag="CAG99_07165"
     CDS             complement(8446..9144)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CAG99_RS07160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CAG99_07165"
                     /product="hypothetical protein"
                     /protein_id="WP_086158173.1"
                     /transl_table=11
                     /translation="MDIRPFDGIDRHTAGPGVLLLPEPGGRRERDPSGLTTGTTWLYPA
                     RHGTAIVILEVPAWAVAAVAAVADPAPHPAPEKAVALAAESLLECVGRVAALVGEPGVR
                     RREESDPFPQAVAERVAVAPGVVDTWLRPDFRYPDGTRPAVTRGSAAALLIAARRIALR
                     AAVMLARSPHAAPAEHRARAGRAAGPGELVTEWCGEPAAEFRQRPVPVAVQAECQARLA
                     LRCAHLSAGG"
     gene            complement(9424..9795)
                     /locus_tag="CAG99_RS27475"
     CDS             complement(9424..9795)
                     /GO_function="GO:0004181 - metallocarboxypeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012471.4"
                     /locus_tag="CAG99_RS27475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="M14 family zinc carboxypeptidase"
                     /protein_id="WP_159029768.1"
                     /transl_table=11
                     /translation="MSLKSSMGYPSVDTLGRIARGLVRRHPRAMRLRTAGRSRGGDPLL
                     LLTVGHGARNVLLVAGLHANEPAGGATSLRLARTSATGATGAGGTTGTGGRVADARGLC
                     DLSRASGISCCFSTRTAPG"
     misc_feature    complement(9610..9612)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            10001..11194
                     /locus_tag="CAG99_RS07165"
                     /old_locus_tag="CAG99_07170"
     CDS             10001..11194
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007387620.1"
                     /locus_tag="CAG99_RS07165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_07170"
                     /product="ThiF family adenylyltransferase"
                     /protein_id="WP_176582875.1"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 6.4e-18,
                     bitscore: 63.0, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="ThiF (E-value: 1.7e-41, bitscore: 140.5,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVGRLWKPRIKPEHTAYRTIEGDIRIGSVVFGIGAEIKDPAGWL
                     WTLTSGADGSRTEEALIGHVLAGHPELTELTADDVGDALRQLNAAGFVEDAAAARPALF
                     SDREAERYSRGLPLLRWMDLSPRTNTWEAQARLKKAAVLLIGLGGVGGVAAQALVASGV
                     GRLHCVDSDRVELSNLNRQTLYHEADIGAGKVAAGVARLRALNSDVTVTGEEASVSTPG
                     DLAALLARGPGEARAWDALLLCADRPPDIRRWTNRTCLAARLPWVDGGYRGPLVSVGVY
                     RPGRGGCWECLRAAEFERRDLRLAPGQDESLASPRMAWNPVNAVTAGLAGSLMAHAALI
                     LLTGVPPTEPGFRFGVNLMALHDTTYSRAPARDDCPACGAPGAPGARSGAEAPGAPV"
     misc_feature    10016..10018
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        10022..10306
                     /aSDomain="Pantocin_Microcin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing E1-like protein in a
                     pantocin/microcin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CAG99_RS07165_Pantocin_Microcin_RRE.1
                     "
                     /evalue="3.30E-20"
                     /identifier="RREFam017.1"
                     /label="CAG99_RS07165"
                     /locus_tag="CAG99_RS07165"
                     /protein_end="102"
                     /protein_start="7"
                     /score="63.0"
                     /tool="antismash"
                     /translation="KPRIKPEHTAYRTIEGDIRIGSVVFGIGAEIKDPAGWLWTLTSGA
                     DGSRTEEALIGHVLAGHPELTELTADDVGDALRQLNAAGFVEDAAAARPA"
     gene            complement(11280..12089)
                     /locus_tag="CAG99_RS07170"
                     /old_locus_tag="CAG99_07175"
     CDS             complement(11280..12089)
                     /GO_function="GO:0016853 - isomerase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009717778.1"
                     /locus_tag="CAG99_RS07170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_07175"
                     /product="sugar phosphate isomerase/epimerase"
                     /protein_id="WP_086162045.1"
                     /transl_table=11
                     /translation="MTTKQLPLPELVKGLVDLGVPGVGLWREPVAEFGLAESAALVADA
                     GLTVTSLCRGGFFTAVEPAERAAALADNRAAVDEAAALGTDTLVLVSGGLPAGSRDLPG
                     ARERIADALAELGPYAAERGVRLAIEPLHPMYAADRCVVSTLAQALDLAERFPAEQVGV
                     VVDTYHLWWDDRVAEQIERAGQGGRIHCFQLADWVTPLPAGVLTGRGQIGDGAVDMRWF
                     RDAVAAAGYRGPVEVEIFNDGLWARDGRQVLTETVDRYREHVLAPVA"
     misc_feature    complement(12112..12127)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 24.26"
                     /tool="antismash"
     gene            complement(12119..13282)
                     /locus_tag="CAG99_RS07175"
                     /old_locus_tag="CAG99_07180"
     CDS             complement(12119..13282)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006135387.1"
                     /locus_tag="CAG99_RS07175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_07180"
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="WP_255308005.1"
                     /transl_table=11
                     /translation="MTNAIRLPEPGGTLRDYQPRAEPLDLAPHGAPLTSRIVFSAAHVV
                     ADPFADTTPDGPAAVDWDSTLAFRRHLWAHGLGVAEAMDTAQRGMGLDWQGAAELIRRA
                     GAEARATGGRIACGVGTDQLTGPADTAAVRAAYEEQLAVVEETGAQAILMASRALAASA
                     RGPEDYAEVYGHLLRQAAEPVVLHWLGPMFDPALTGYWGSEDLDAATDTFLGIIEAHQD
                     KVDGVKVSLLDAEREVRLRRRLPAGVRCYTGDDFNYPELIAGDEQGFSHALLGIFDPLG
                     PLAADAVRTLDTGDVAGFRKRLDPTVELSRHLFQAPTRYYKTGVVLLAWLAGHQDHFTM
                     VGGLQSARSLPHLARAYELADGLGLFPDPALARDRMAGLLATHGVTP"
     gene            complement(13296..14459)
                     /locus_tag="CAG99_RS07180"
                     /old_locus_tag="CAG99_07185"
     CDS             complement(13296..14459)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006135388.1"
                     /locus_tag="CAG99_RS07180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_07185"
                     /product="Gfo/Idh/MocA family protein"
                     /protein_id="WP_086158174.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 1.1e-08, bitscore:
                     34.1, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 1.7e-25,
                     bitscore: 87.7, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTKKTVRIAMNGVTGRMGYRQHLVRSILAIREQGGVDLGDGSVI
                     WPEPVLVGRREHALREIARQHGLDPETDVTTDLDAVLADDSIDIYFDSQITLTREAAIK
                     RAIAAGKHIYTEKPTATSLDGALALARLAKDAGVKHGVVQDKLFLPGLRKLKRLIDGGF
                     FGRILSVRGEFGYWVFEGDWQPAQRPSWNYRSEDGGGIVVDMFPHWEYVLHELFGRVET
                     VQALTATHVPQRWDEQGKPYQATADDAAYGIFQLEGGIVAQINSSWSVRVNRDELVEFQ
                     VDGTEGSAVAGLRNCRVQHRSATPKPVWNPDLPATEVFREQWQEVPDNGEFDNGFKAQW
                     ELFLRHVVLDEPYTWDLLAGARGVQLAELGLASSSDGRRLTVPELSL"
     misc_feature    complement(14482..14493)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.34"
                     /tool="antismash"
     gene            14548..15594
                     /locus_tag="CAG99_RS07185"
                     /old_locus_tag="CAG99_07190"
     CDS             14548..15594
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019435701.1"
                     /locus_tag="CAG99_RS07185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_07190"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_086158175.1"
                     /transl_table=11
                     /translation="MSVTLADVAARAGVSAATVSRVLNGNYPVAGATRTRVLRAVEELE
                     YVVNGPASALAAATSDLIGVLVNDIADPFFGIMAGAVQSEIGQATRKLAIVCNTGGSPE
                     RELTYLTLLQRQRASAVVLTGGAVEDAAHGAALATRLRRLDAAGSRVVLCGRPPLATEE
                     DGPHPLALTFDNRGGARRLTEHLLSLGHRRLGYLSGPAARTTTRHRLEGHRAAMAAAGL
                     AADAERLTTHGGYDRASGYDGTLELLRRDPDLTAILAANDTVALGVCAALRDRGLRIPQ
                     DVSVTGFDDLPFAVDAVPALTTVRLPLHDAGARAGRLALGREDAPPGGVATFHGDLMVR
                     DSTAPPRP"
     gene            complement(<16149..16658)
                     /locus_tag="CAG99_RS07190"
                     /old_locus_tag="CAG99_07195"
                     /pseudo=""
     CDS             complement(<16149..16658)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019062147.1"
                     /locus_tag="CAG99_RS07190"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_07195"
                     /product="GNAT family N-acetyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSTEITRLDTPEGLLAHARELGVLLADVVADGASIGFVAPFGAEE
                     AAAWWAARAPACGDGLTVWTARVGRLLVGTAGLVRAPQANGRHRAEVVKLMVHPGARGR
                     GVAAALLATAEQAAWESGVKLLLLDTETGSAAEHLYRSAGWTKFGEVPDYAADPAGTLR
                     ASSFFHK"
     gene            complement(16655..17248)
                     /locus_tag="CAG99_RS07195"
                     /old_locus_tag="CAG99_07200"
     CDS             complement(16655..17248)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431309.1"
                     /locus_tag="CAG99_RS07195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_07200"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_086158177.1"
                     /transl_table=11
                     /translation="MGDVSEGVAGPPAGSVEARLAGRLAELRSERGWSLEELADRSGVS
                     RSTLSRVERAEMSPTAAMLGKLCTVYERTMSRLLSEVEREPPGPVPAGSQEVWTDAATG
                     FVRRSVSPPHAGLRGEVMEGRLREGAVITYEAPPVPGLEHHVWVLDGAVEVTVGEKTHA
                     LGEGDCLRFRLWGPSGYRCPGPGAARYVVVAVLP"
     gene            17513..18067
                     /locus_tag="CAG99_RS07200"
                     /old_locus_tag="CAG99_07205"
     CDS             17513..18067
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016407 - acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Mac"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156: Chloramphenicol acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003946611.1"
                     /locus_tag="CAG99_RS07200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_07205"
                     /product="sugar O-acetyltransferase"
                     /protein_id="WP_176582876.1"
                     /sec_met_domain="Mac (E-value: 7.6e-13, bitscore: 46.8,
                     seeds: 568, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGTQKERMLAGELYIADDPEIAADAARAIRLTEEFNATATADAAT
                     RRAALVALLGEVGEGTEVRPPLRVDYGTYISIGPRTFVNTGAVLLDVARITIGADVQIG
                     PNVQLLTPTHPVEPGPRREKWEAAAPITIGDNVWLGGGVIVCPGVTIGENTVVGAGAVV
                     VKDLPANVVAVGNPARVVRSV"
     misc_feature    complement(17527..17540)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.03"
                     /tool="antismash"
     gene            18160..20292
                     /locus_tag="CAG99_RS07205"
                     /old_locus_tag="CAG99_07210"
     CDS             18160..20292
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014181003.1"
                     /locus_tag="CAG99_RS07205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_07210"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_255308006.1"
                     /transl_table=11
                     /translation="MTSLRRGGKGGVFALLLVYLALLAALQIWSGRNNLTGWSGFSVLA
                     PMVAGALLSLRDTFLVGLLTVASIVIAYGGTIPGLSPGTRVVIYSAAICASALGLVICR
                     IRLNREARVSRLTIARERLTLLRVASRHVGSTLDVRRTAREVTEVAVPGFADLVTVDLF
                     DSVLRGDEPGGPDGVARRLRRVAHRSATGAGPREGPRDRGEGARPQREDRSARGETAAP
                     TDAADPAEATAPDARARILDDAEVAAWLEANPACAAPRTRGNGRSGIAVPLRARGTTLG
                     IAMFVRHLRADPFDADDLLLAEEIGAQAAVCVDNARRYTHEHRASLTLQQSLLPRRLPE
                     VAAVEVATRYLPADSTAGVGGDWFDVIQLSGARVALVVGDVVGHGLYASATMGRLRSAV
                     RTLADIDLAPDELLTHLDDVVIRLRSETEGNDPEQTGEGTAESPAGAVGATCLYAVYDP
                     ASRVCTMARAGHPAPALVRPDGRAEFVDAPAGQPLGLGGLPFEAHEVLLPEGSYLALYT
                     NGLIAREHDMERGQATLRQALSRPAPSADAVCETVLGAMLDDGQTDDIALLVARTRALD
                     AAHVATWNIPDDPTAVAHARELADRQLTVWGLPDAAFTTELVVSELVTNAIRHADGPIQ
                     LRLIREPSALICEVSDNSSTSPHLRRARALDESGRGLFIVAHLTARWGTRHGREGKTIW
                     AELSPTPSPDALLAAG"
     gene            20403..20885
                     /locus_tag="CAG99_RS07210"
                     /old_locus_tag="CAG99_07215"
     CDS             20403..20885
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016469098.1"
                     /locus_tag="CAG99_RS07210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_07215"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_086158178.1"
                     /transl_table=11
                     /translation="MTDSAPPLASGPLGMRLLAFDRVPEDTRFDDGVPVGYSLVALWRA
                     GLLLLVHVRGRDCWELPGGGLDPDETPRQAAARELAEESGQHVAPRRLRFAGFALTSLP
                     GRGVLRGAVYRAETDAAEPFAPTAEISGVHWWDGAGPLPHGRLQTVDARLAELVGR"
ORIGIN
        1 ccatccgagc ttccacttgt gccatccgaa cagctcgggg gacaggccga actggctgcc
       61 catgaggtcc cagtccccga cgtgcgtgtc ccagtccccc cagccgttct ccggccggtc
      121 gtagaggtcg ggcaggtcga agacgtgacc ggtctcgtgg gcgagcacgt tgcggtcggg
      181 gcggcgctgc tcgaagaccg tgacgaggcg gcggatctcg gcgtcgccga cggtgaccgg
      241 cttgtcgaag ttcaccacct tggtcgcgtc cgggtccacg ccgggcgcgt ccgggtcggc
      301 gaccaggtag acgatgtcgt aggcggcgag gtccacccgt cccgagacgg tcttcagggc
      361 gtccttgaga taggcggagc gccggtccgg ctcccagtcg cgccgtatgc cgtactcctg
      421 cgacgtgccc ggcatgcgca gccactcggg caccacctcg gtccgcaggt cgagctttcc
      481 gtaggaggcc gcgcggaagt agtcggtggt ggcggggaag tagtccgccg cgatccgctc
      541 cgggctcagc cgcggcgcgg cgtcggtgaa ggagaggaac agcatgacgc cgcgcacggt
      601 gcccacgggg cgcgggtagg cgtcgttcca gctgtccacg ccctcggagt ggtggacggc
      661 ggaacgcggc aggctgcacg gctcgtcggc gagggcggag atgccagggc cctcggtgag
      721 ggtggcgccg agcagggcgg ccagtacggc cagcacggcg gcggggcggc ggcgggcacg
      781 gcgcacggcg acctccgatc gggcctcggg cgggacacgg gaagcgggaa acgggcagaa
      841 cgtcagggac gggcggggcg gaaggggcag gaggggcggg agcggacgcg tgggtcgggc
      901 gaagcctgcg ggagggaacc gggggaacgg aggagggacg gggcggacag cgggagcacg
      961 ctcaccaccc tgttccggat tccccgtttt tgccctgttt cgatagcccg gccgggtcat
     1021 ggcaatacga ttaccctgcg tatacttctg tcgggaacga tcccgagagc acacccgacg
     1081 ggcagaaacg atcagctact cgaaagtctg tcggaagcac aggtttcggg ttacgaaacg
     1141 gacgcgacgg gcactggctc cacccgcgcc gcagcctcta tgatcgccac atttccagcg
     1201 cggatacgcc aagcgggcag ccggggagcg cccgacagca ccatcgggag cgatcggtga
     1261 acggacccca cgaaacaccg ggccacgacc ccggcagcgc ccaccaggcg aacccaccgt
     1321 cccttacgga acgtgacctg ctcagggact accgggccgc gttccagatc gcccagttcc
     1381 ccatggcgct cgtcggcgcc gcgggccaga tcctcgccgc caacgccgcg ttcgggctcc
     1441 tcctcggagt cgagccggaa cgcctcgccg gtgtgcgcgc cgacgccgtc gccgggctcg
     1501 gcctcgacgg gcgcacgcgg ggctcctacc acgcggtgct gcgcggccac agcgaccacc
     1561 tgcgctgcac gcggcggctc aagcacgccg acgggcacag cctgtgggcc gaggtgacgg
     1621 tcctgcccac cccgacggag agctcggcgg ccctgctgac cgtgctcgac atcagcgagc
     1681 ggcgcgcgct ccaggagcgg ctgcgccaca tccagatgca cgacccggtc acccggctgc
     1741 cgaaccgggc cctgttcttc gagcggctga cggccgcgct ctccgactcc gccaccgggc
     1801 ggatcgggct gtgccaggtg ggcatcgacg gcttcaaggc ggtcaacgac accctcggcc
     1861 accgcgtggg cgacgaattg ctcggcgcgg ccggccagcg cctcgccgag tgtgccacgg
     1921 gtgcgggcgg gcacctcgtg gcgcggctcg ggggcgacga gttcgccgtg ctcgttgagg
     1981 ggtcgaccgg caccgagcag ctgaccgagc tggccgagac catgctcgcc gcgctgcaac
     2041 gcccgttcga cctggccggg cagcggctgg ccgtctcggc cagcatcggc gtggtcgagc
     2101 gcgagtccgc cacgaccacg gccaccgggc tgatgcaggc ggccgacacg acgctgtact
     2161 gggcgaaggc cgacggcaag gcccgctgga cgctgttcga ccccgagcgc aacgcgcacc
     2221 ggatgacgcg gcagtcgctg tcctcgacgc tgcggcgcgg tgtggaccgc ggcgagttca
     2281 cgctggagta ccagccgatc gtcggactgg ccgacgacat cgtacgcggc gccgaggcgc
     2341 tggtgcgctg gcggcacccg cagttcggaa cgctcggccc cgaccggttc atcggcctcg
     2401 ccgaggagaa cggcgcgatc gtgccgctcg gccgctggat tctcggcgag gcgtgccggc
     2461 aggcccgccg ctggcaggtg gagcacccgg gaccgcccct gttcgtcagc gtcaacgtcg
     2521 ccgtccggca ggtgtgggac tccgacctgg tcagcgacgt ggccaaggcg ctcgacgact
     2581 cgggcctgcc ctcagggctg ctccagctcg aactcaccga gtcggccgtc atgggctcgg
     2641 ccgggcgccc gttgcaggcc cttcaggccc tggccgacat gggcgtgcgg atcgcgatcg
     2701 acgatttcgg caccgggtac tccaacctgg cctacctcag ccggctcccg gtgcgcgccc
     2761 tgaagctgga cggcatgttc gtgcggggct tccgcaccgc gcgccacctc aacccggccg
     2821 acgagacgat cgtcagctcg ctcgtccagc tcgcccacaa gctcggcctc accgtgaccg
     2881 ccgagtgcgt ggagggcccg gcgcaggcgg agcggctgcg ccgcatcggc tgcgacaccg
     2941 ggcagggctg gcactacgcc cgcccgatgt cgcccgacca cctcgccgac ctgctcgccg
     3001 gccgcgactg aacgcccgcg gcgaccggcc gcgcgcccgc ccgacggccg ccggtgcgcg
     3061 gtccgttccg ccgttcccgg gtgaaccggg cggctgcggc cctgtacgcg cggcggcgct
     3121 gacggaatac tcccggacca tgacgatcat ggctgaatcc atccccctcg accgcttcct
     3181 gcggctgctg gccgacgagt ccgtcccggt ggtgcaccgc gccctgtggg cgcttctgtg
     3241 ggagagcgac gtgcgcgtgc tcgacctcct cgcccttgag gtggcggacg agtcccggat
     3301 aagaccccag gccggcggcg cactcggcgg gcaggcggaa acgctgctgg cccggctggt
     3361 cgccggccgg acgagcggcc cgctgttcgc ggtcgggggg cggaccctgt cctgggacga
     3421 ggcggtgcgg accgcggggg ccgcgggcgt gcccatccac gcgttccgca ccagcggccg
     3481 ccagcaccgc ggcgcgctct gaggcggccg accggcggcc cggtcccgcg acgcgcacgc
     3541 ggcgcacgcg gcgcgggacc ggtcggccgg tcccgcgccg gggcgcgggg cgggcgcgtc
     3601 cgggcgcgcc gggcgctgcc gacccgcctg cgcccgcctc agctctcccc ggcccgcacc
     3661 ggccgcggcg cggcgaagag gccgcccagg gccgggcaga cgggcgtgtg ccccagcagg
     3721 cgaagccctt cccaggcggt cacctgattg gccgtgagca ccggcttccc tgccgcggcc
     3781 tcaagttccg gcagccaggc ggcggtgtgc agcgcggtgt cgggcagcag caccgcgtcc
     3841 gccgccgggt cgtcgccctc gcgcagcagc cgcagcacct cctcgcggcc ccacgtgccc
     3901 acctcggccg ccgtgatgat gccgctgccc cgcaccccgg tgacctccac gcccgccgcc
     3961 ttcaggaagt cgccgaacag acccgcgacg tcgtcggggt acgtcgccgc gacggccacc
     4021 cgggtgacgc ccatggcgcg ggcggcgcgg gcgaacgcga acgacgtgct cgacgccggc
     4081 aggcccgcgt gcgcggcgag gcgccgcacc tggtcggccg cgccgtccca gccgaagacg
     4141 aaactcgcgc tggtgcacgc ccacaccacg gcctgcgcgc cccgcgcggc cacctcgtcg
     4201 agtcccgccg tgagccggtc gaccgagccc atctccagca gcgcgtccac ccggtgagcg
     4261 tccgtgccga tgtcggtgtg caccaggggc agcaggacac cggcgcccgc gtcgttcagc
     4321 aggcgctcca tgcgggggaa gtcgtcctcc gccgagtgtc ccgggtacag gaatccaacc
     4381 gtcgcggcca tacgggtctc acccttcctc gtcggggaat gccggcggcg gcaccgccgg
     4441 tgccacctcc tgaccgccgg cctcggacgt catcgacgcg gggccctgcc gggccaccgg
     4501 gtcgagcagc gcctggtagg ggccgacggc ctccttgccg atggaccgca gcgcggacca
     4561 catcgtcacc tggttcgccg agatcaccgg catccgcaac tcggcctcca gctgcgggat
     4621 gacgtcgtag gtgggcaggt tggtgcagct gatgaacagc gcctcgggcc cctcggccac
     4681 cgcctccctg gccatggcga ccacgtcccg gtacgccacc cgccagatct ccctggtcag
     4741 gcccaggtaa ctgcgcccgc agacctggat gcccgcctcc ctgaggtagt cctcaagcga
     4801 gtccgtcacc gacttcgtgt acggcgtgac cacggcgacc cggcgcgcgc ccagctcgtt
     4861 cagggcgccg agcagggcgc ccgacgtggt gagcgccggc agctcgccgg cctgccgcat
     4921 ggcggcggac atggcgcgtt cgccgacgac gccgccgacg aaactgcccg aggtgcacgc
     4981 gtaggccacc acttcgggac tgaccgccga cagcgcgcgg accgcctcgc gcagcgtctc
     5041 gtgctcgctg accagccgcg cgaggtcgag actgacctcg accgggacga acggcgtccg
     5101 cgtcaggtgc agcgagacgt catcgggcac ccaccgccac agttcgcggt cgagcgcgaa
     5161 atcgaatggt gcgacgactc cgatgccccg ctgcgggagc gggccaccca aaaaggagac
     5221 atccatgtcg aaccccgctt caacgggccg ggaataccgg gagggatgta agagcagaaa
     5281 gagcagatgc cttcattgac gaaggtagat acgagttcct accgtggtca atccttgact
     5341 tccagccaaa caaagcctcg ttgcggaacg gtttccctct catgtcagaa gcccgtgtgc
     5401 tcgtcctcga cgcacaaccc ccgccccgac tcgaccggct tgcgggccgg gcgcgcgtgc
     5461 tgcacagtga tgagagttcg ctgcacggcc tgttgcccga ggcggacgtc ctgctcgtgt
     5521 gggacttcac ctccgacgcg gtgcgcgcgg cgtggccggg tcccgggccg cgaccgcgct
     5581 gggtccacac cgcgagcgcc ggtgtggacc ggctgctctt tcccgaactg ctcgaatccg
     5641 acgcggtggt gacgaacgcc cgcggtgtgt tcgaccggcc gatcgccgaa tacgtggccg
     5701 ggctcgttct cgccatggcc aaggatttcc ggcgcagcct tgagttccag cgcgcacacc
     5761 gctggcagca ccgggaaacc gacaaggtgt tcggcagccg ggccgtcgtc gtcggctcgg
     5821 ggcccatcgg ccggcgcatc gggacgacgc tgggcgcgct gggggtgacg gtgcgcctgg
     5881 tcggccggac cgcgagggcg gccgaccccg acttcggccg ggtgcacgcg ggcgaggagc
     5941 tgcccgcgct gctgccggac gccgactggg tggtctgcgc ggcgcccctg accccgcgga
     6001 ccacgggcat gttcgacgcg gcggccttcg cgctcatgaa gcccaccgcg cgcttcatca
     6061 acgtcggtcg cggcgcgcac gtcgtgcagg acgacctcgt ggccgcgctg cgcgccggcc
     6121 ggatcgcggg agccgccctg gacgtgttcg cgaccgaacc gctgccggcg acgagtccgc
     6181 tgtgggacct tccggatctg atcatttcgc cgcacatgtg cggcgacacc catggctggc
     6241 gcgacgacct cgcggatcag ttcctcgaca acttcgatcg ctgggtggcg ggcgaaccgc
     6301 tggccaacgt cgtcgacaaa catctgggct acgtccccgc ggagggctga tgaccgatct
     6361 gtgttccctg accgcgctcg aactgaccgc gcgctacgcg gccggcgacc tctcccccgt
     6421 cgaggtggcc gaggcggccc tcgcccgggc cgacgcgatt cagccggtgg tgaacccctt
     6481 cgtgttcacc gatcccgagg gggcgctcgc gcaggcgcgc gccgccgagg agcgctgggc
     6541 gcgcggcgcg cccgccggtc ccgtggacgg cgttcccgtg acggtgaagg acatcctgct
     6601 ccagcgcggc catcccacgc gccgcggctc cgcggccctg cccgccggcc cgggaccgtg
     6661 ggaggaggac gcgcccgcgg tcgcgcggct gcgggagtcg ggcgccgtgt tcctcggcaa
     6721 gaccaccacg cccgagttcg gctggaaggg cgtgacggac gcgccgctgt ccggcgcgac
     6781 cggcaacccg tacgcgccgg agcgcacctc gggcgggtcg agcggcggaa gcgccgccgc
     6841 ggtcgcgctg ggcgccggcc cgttgagcct ggggacggac ggcggcgggt cggtgcggat
     6901 tccggccgcg ttctgcggcg tcttcgcgct gaagcccacc tacgggcggg tcccgctgta
     6961 cccggcgagc gccttcggca ccctcgcgca cgtcggaccg atgacgcggg acgcggccga
     7021 cgcgaccctg ctgctcgacg tgatcgccca cccggacgcg cgcgactggt cccacctcgc
     7081 ccccggcggc gtgccgttca ccgaggcgct ggtgccgggc gccgagggtc tcgcggggct
     7141 gcgcgtcgcc tggtccccca ccatgggcgg ggtcgtggtg gcacccgacg tggccgcggt
     7201 cacgcgggac gcggtggaac ggctggccgc gctcggcgcc gaggtcaccg agaccgaccc
     7261 gccgctgccg ccgctgccgc gggtgcgcgc cgcgttccag acgctgtggt tctccggagc
     7321 ggcccgcgtg acccagcact tcgacgaggc gcagcgggcc gcgatggacc cggggctgcg
     7381 cgaggtcgtg agcgccgggg cgcggttcgg ggcgctcgac tacctggagg cggtcgacct
     7441 gcggatggag atggggcggc agatgggcgc gttccacgag gagttcgacc tgctggtgac
     7501 gccgacgctg ccgatcacgg cgttcgggcg gggcgtcgag gtgccggacg gctcgggact
     7561 gacccggtgg acggagtgga cgccgttcac ctatccgttc aacatgacgc agcagcccgc
     7621 ggcctcggtg ccgtgcggca ccggcgcgga cgggctgccg gtcgggctgc atttgatcgg
     7681 cgcgcggcac gcggacgcgc tggtgctgcg cgccgcgcac gccctctacg agacgggcgt
     7741 ggcaggcgtt cccgcgccgg cgctcgcggc gagcgcgccg ggcgcctgac cgccggtcct
     7801 tccgcctggg cgcgcggggc gcgcgcccgg gcgggccggg tcaggcccgg gtgcggggac
     7861 tcacgcgcgg cggaagttca ggctctcgcc gagggcgccg gcccgccaca ggtcctgaca
     7921 ggcgtccgcc atgcggtcga ggccgtccac cacggtgccc cagacgatgc cgggcaccca
     7981 gcccgcgtca ccgttgatca gcaggttgtt gcgctcatag aacagcgcca ggtccaccac
     8041 cgtcgtgcgg ccctggtgct tcgcgtcgtc ctcgtacccg taggagctgg tgccgagctg
     8101 ggtgtcggag aacgtgaagt agcacaggtc gccggggatc ggcgtgaccg tcgggttctc
     8161 cagcggcggt tcctgcggcg cgaacggcgg caccagcgcg tagatctcgt tgcgcgcgta
     8221 cttcgcgtgg tacacgtcgc cgcccagcgg cagcgcgttc cacacggcgt cgcacgtgat
     8281 cggcgcgcgg tcgctcagca gccgggcggt acagctgacc ccgcgcttgt cgagcgagac
     8341 ggtgatgaac cggtcgtcgg cgttcgtcat gggttgcctc ctggtggtgg ggcgggccga
     8401 acccaccatg ccacgccgaa gggccgcggc gcggcggcgc gttcgtcacc cgccggcgga
     8461 caggtgggcg cagcgcagcg cgaggcgggc ctggcactcg gcctgcacgg cgacgggcac
     8521 ggggcgctgc ctgaactcgg ccgccggctc cccgcaccac tccgtcacca gctccccggg
     8581 gcccgcggcg cgcccggcgc gcgcccggtg ttccgccgga gcggcgtgcg gcgacctggc
     8641 gagcatcacc gccgcgcgca gcgcgatgcg gcgggcggcg atcagcaggg cggcggcgct
     8701 gccgcgcgtg accgcgggcc gcgttccgtc ggggtacctg aagtcgggcc ggagccaggt
     8761 gtcgacgacg ccgggcgcga cggcgacccg ttcggccacg gcctgcggga acgggtcgga
     8821 ctcctcgcgg cgccgcacgc ccggctcccc gaccagggcg gccacgcggc cgacgcattc
     8881 gagcaggctc tccgcggcca gcgcgacggc cttctccggg gcggggtggg gcgcggggtc
     8941 ggcgacggcg gcgacggcgg cgacggccca ggccggaacc tcaagtatca cgatcgccgt
     9001 gccgtggcgc gccgggtaca gccacgtggt gccggtggtc agccccgagg ggtcgcgttc
     9061 gcggcgcccc ccgggctcgg gcaggaggag gacgccaggg cccgccgtgt gccggtcgat
     9121 tccgtcgaac gggcggatgt ccacgaatgg acagggccct ggccacatcg cgcagggcgc
     9181 cgctgagccc gggaatgccg cgcgtgctct gcacgaatgc gccgcccatt tcacttccgt
     9241 gcagggagaa ttgcacctcc gggcgcagct cgtcgagcaa agcgagcagg gtttccgatt
     9301 cgggcagccg cgggcgcccc tcatccggca tgggcaggaa ttccggctgg ctcgcgaaca
     9361 gcggccggta gaatccatga atatattgat ggaggtcggg cggtccgtgc agccagctct
     9421 cgttcagccg ggcgccgtcc gggtcgagaa acagcaggaa ataccagaag cgcgcgacag
     9481 atcgcacagc ccccgcgcgt cggccacccg cccgcccgtg ccggtcgtcc ctccggcacc
     9541 ggtcgcaccg gtggccgacg tgcgcgccag tcgtagtgaa gtcgccccgc ccgcaggctc
     9601 gttggcgtgt aatccggcga ccagaagaac gttgcgcgcg ccatggccga ccgtgaggag
     9661 cagcaacggg tcgcccccgc gcgagcgtcc cgccgtcctc agccgcatgg cccgcggatg
     9721 gcgccgcacc aggccgcgcg cgatccggcc cagggtgtcg accgatgggt aacccatgct
     9781 gctcttcaac gacaccggga ttccaagtct gtgggcggcg cggcgccgga cgcgattacg
     9841 taccgatgga gttgctctcc cccgtggtct ccttcttttc cagcggtcgt atctcgatac
     9901 gggtcatgcc gcccccttcc atggcctgac gtctgcttgc aagtgttcgc cggtcggggc
     9961 agagtgtcaa gggtcggacc agtcaattgg gcaggaacat atggccgttg gacggttatg
    10021 gaagccgcgg atcaagcccg agcacaccgc ttatcgcacc atcgagggag acatccgtat
    10081 cggcagcgtc gtcttcggaa tcggcgccga gatcaaggac cccgcgggct ggctgtggac
    10141 cctcacctcg ggcgcggacg gcagccgcac cgaggaggcg ctgatcggcc acgtcctcgc
    10201 cggccacccg gagctgacgg agctgacggc ggacgacgtc ggcgacgcgc tgcggcagct
    10261 gaacgccgcc ggcttcgtcg aggacgccgc ggcggcgcgc cccgccctct tctccgaccg
    10321 cgaggcggaa cggtacagcc gcggccttcc gctgctgcgc tggatggacc tgtcgccgcg
    10381 cacgaacacc tgggaggcgc aggcccggct caagaaggcc gcggtgctgc tgatcggcct
    10441 cggcggggtc ggcggggtgg cggcccaggc gctggtcgcc tccggtgtcg ggcgcctgca
    10501 ctgcgtcgac tccgaccggg tcgagctgtc caacctcaac cggcagacgc tgtaccacga
    10561 ggcggacatc ggcgccggca aggtcgcggc gggcgtcgcg cgcctgcggg cgctgaactc
    10621 cgacgtcacg gtgaccggtg aggaggccag cgtgagcacg ccgggcgacc tggcggcgct
    10681 gctggcccgg ggccccgggg aagcccgggc ctgggacgcg ctcctgctgt gcgccgaccg
    10741 gccgccggac atcaggcgct ggacgaaccg cacgtgtctg gccgcgcgcc tgccctgggt
    10801 cgacggcggc taccgcggcc cgctggtcag cgtcggcgtg taccggccgg gccgcggcgg
    10861 atgctgggag tgcctgcggg cggccgagtt cgagcggcgg gacctgcgcc tcgcaccggg
    10921 acaggacgag tcgctggcct ccccgcgcat ggcgtggaac ccggtgaacg ccgtcaccgc
    10981 gggcctcgcc ggcagtctga tggcgcacgc ggcgctgatc ctgctgaccg gggtcccgcc
    11041 gaccgagccc gggttccgct tcggcgtcaa cctgatggcg ctgcacgaca cgacgtactc
    11101 ccgggccccg gcccgggatg actgccccgc ctgcggggcg cccggcgccc ccggggcccg
    11161 gagcggcgcc gaggcgccgg gcgcccccgt ctgaacgccg cgagggcacc ggcccgggcc
    11221 ggtgccctcg cggtacggga ggccgccgcc gcggtgggac cggcgcggcg ggccgttcgt
    11281 cacgcgaccg gggccagcac gtgctcccgg tagcggtcca cggtctcggt gagcacctgc
    11341 cggccgtccc gcgcccacag gccgtcgttg aagatctcca cctccacggg accgcggtac
    11401 cccgcggcgg cgacggcgtc gcggaaccag cgcatgtcca ccgcgccgtc cccgatctgc
    11461 ccgcgcccgg tgaggacccc ggcgggcagt ggcgtgaccc agtcggcgag ctggaagcag
    11521 tggatgcgac cgccctgccc ggcccgttcg atctgctcgg cgacccggtc gtcccaccac
    11581 aggtggtagg tgtccacgac gacgcccacc tgctcggcgg ggaagcgttc cgcgaggtcg
    11641 agcgcctgtg cgagcgtcga gacgacgcac cggtccgccg cgtacatcgg gtgcagcggc
    11701 tcgatcgcca gccgcacgcc gcgctcggcc gcgtacggcc ccagctcggc cagcgcgtcc
    11761 gcgatccgct cgcgggcgcc cggcaggtcg cggctgccgg ccggcagccc gccggagacc
    11821 agcacgaggg tgtcggtgcc gagcgcggcg gcctcgtcca cggcggcccg gttgtcggcc
    11881 agcgccgccg cccgctccgc cggctcgacg gccgtgaaga atccgccgcg gcacagcgag
    11941 gtgacggtca gcccggcgtc ggcgaccagc gcggccgatt ccgcgagtcc gaactcggcg
    12001 accggctcgc gccacaggcc gacgcccggc acgccgaggt cgaccagccc cttgaccagc
    12061 tcgggcagcg gcagctgctt ggtcgtcatc tggttgatgg agaacccggc cagatcgctc
    12121 acggcgtcac cccgtgcgtc gccaggagcc ccgccatgcg gtccctcgcc agcgcggggt
    12181 cggggaacag gccaagaccg tcggccagtt cgtaggcacg cgccaggtgc ggcagcgacc
    12241 gcgcggactg aagcccgccg accatcgtga agtggtcctg gtgcccggcc agccaggcca
    12301 ggaggaccac gcccgtcttg tagtagcggg tcggcgcctg gaacaggtgc cgcgacagct
    12361 ccaccgtggg gtcgagccgc ttgcggaagc ccgcgacatc gccggtgtcc agcgtccgca
    12421 ccgcgtcggc ggccagcggg ccgagcgggt cgaagatccc gagcagcgcg tggctgaagc
    12481 cctgctcgtc gccggcgatc agctccgggt agttgaaatc gtccccggtg tagcagcgca
    12541 cgcccgccgg cagccgccgg cgcagccgca cctcgcgctc ggcgtcgagg agcgacacct
    12601 tgaccccgtc caccttgtcc tggtgggcct cgatgatgcc gaggaacgtg tcggtcgccg
    12661 cgtcgaggtc ctcgctgccc cagtagccgg tgagggccgg gtcgaacatc gggccgagcc
    12721 agtgcagcac gaccggctcc gccgcctgcc gcagcaggtg cccgtagacc tccgcgtagt
    12781 cctcgggacc gcgcgccgac gcggccagcg cccgcgacgc catcaggatc gcctgggcgc
    12841 cggtctcctc gacgaccgcg agctgctcct cgtaggccgc ccgcaccgcc gcggtgtccg
    12901 ccgggccggt cagctggtcg gtgccgacgc cgcacgcgat gcgcccaccg gtcgcgcgcg
    12961 cctccgcgcc cgcgcggcgg atcagctcgg ccgccccctg ccagtccaga cccatgccgc
    13021 gctgggcggt gtccatggcc tcggcgacgc cgaggccgtg cgcccacagg tggcggcgga
    13081 aggccagcgt gctgtcccag tccaccgccg ccgggccgtc cggcgtggtg tcggcgaacg
    13141 ggtcggcgac cacgtgcgcg gccgagaaca cgatgcgcga ggtgagcggg gcaccgtgcg
    13201 gtgcgaggtc gaggggctcg gcgcggggct ggtagtcgcg cagtgtgccg ccgggctccg
    13261 gcagccggat ggcgttcgtc acggtcggtc ctccctcaca ggctcagctc gggaacggtc
    13321 agccgccggc cgtccgacga ggaggcgagc cccagctcgg ccagctgcac gccgcgcgcc
    13381 ccggccagca ggtcccaggt gtacggctcg tcgagcacca cgtgccgcag gaacagctcc
    13441 cactgcgcct tgaacccgtt gtcgaactcg ccgttgtccg gcacttcctg ccactgctcg
    13501 cggaacacct cggtggcggg caggtccggg ttccacaccg gcttcggcgt ggcggaacgg
    13561 tgctggaccc ggcagttgcg caggcccgcg accgcggagc cctcggtgcc gtccacctgg
    13621 aactccacca gctcgtcgcg gttgacgcgc accgaccacg aggagttgat ctgggcgacg
    13681 atgccgcctt cgagctggaa gatgccgtag gcggcgtcgt ccgccgtcgc ctggtagggc
    13741 ttgccctgct cgtcccagcg ctggggcacg tgcgtcgcgg tcagcgcctg cacggtctcc
    13801 acccggccga acagctcgtg cagcacgtac tcccagtgcg ggaacatgtc gacgacgatc
    13861 ccgccgccgt cctcggaacg gtagttccag gaggggcgct gcgcgggctg ccagtcgccc
    13921 tcgaacaccc agtagccgaa ctcgccgcgc accgacagga tgcgcccgaa gaagccgccg
    13981 tcgatgagcc gcttgagctt gcgcaggccc ggcaggaaca gcttgtcctg caccacgccg
    14041 tgcttgacgc ccgcgtcctt cgccagccgg gccagcgcga gcgcgccgtc gagcgaggtg
    14101 gcggtcggct tctcggtgta gatgtgcttg cccgcggcga tggcccgctt gatggcggcc
    14161 tcacgggtga gcgtgatctg cgagtcgaag tagatgtcga tgctgtcgtc ggcgagcacc
    14221 gcgtcgaggt cggtcgtcac gtcggtctcg gggtcgaggc cgtgctgccg cgcgatctcc
    14281 cgcagcgcgt gctcgcggcg tccgaccagc accggctcgg gccagatcac cgagccgtcg
    14341 ccgaggtcca caccgccctg ctcacggatc gccaggatcg aacgaaccag gtgctgccgg
    14401 tagcccatgc gcccggtgac gccgttcatc gcgatccgga ccgttttctt ggtggtcatg
    14461 ccttccctcc cacagagcgc agtaagcgct ttctacccgg agagaagcta acctctcccc
    14521 accggctagg acaagtggga gcagagcatg tcagtcacgc tggcggacgt ggccgcccgc
    14581 gcgggggtgt ccgcggcaac ggtttcccgc gttctcaacg gcaactatcc cgtggccggc
    14641 gccaccagga ccagggtgct gcgggccgtc gaggagctgg agtacgtggt gaacgggccg
    14701 gccagcgcgc tggccgccgc cacctccgat ctgatcggag tcctggtcaa cgacatcgcc
    14761 gacccgttct tcgggatcat ggcgggggcg gtgcagtcgg agatcgggca ggcgacgcgc
    14821 aagctggcca tcgtgtgcaa caccggcggc tcccccgaac gcgagctgac ctatctcacc
    14881 ctcctccagc gccagcgggc ctcagccgtc gtgctcaccg gcggggcggt ggaggacgcc
    14941 gcgcacggcg cggcgctcgc cacgcgcctg cgccggctgg acgcggccgg atcgcgggtc
    15001 gtgctgtgcg gccggccgcc gctggccacc gaggaggacg gaccgcaccc gctggccctg
    15061 acgttcgaca accgcggcgg cgcccggcgc ctgaccgagc acctgctgtc cctcggccac
    15121 cgccgcctcg gctatctctc cgggccggcc gcccgcacca cgacacgtca ccggctggag
    15181 gggcaccggg cggccatggc cgcggcgggc ctcgccgcgg acgccgaacg gctcaccacg
    15241 cacggcgggt acgaccgcgc ctccggttac gacggcacac tcgaactcct gcggcgcgac
    15301 ccggatctga cggcgatcct ggccgccaac gacacggtgg ccctcggtgt gtgcgcggcc
    15361 ctgcgcgacc gcgggctgcg cattccgcag gacgtgtccg tgaccggctt cgacgacctg
    15421 ccgttcgcgg tggacgccgt gccggccctg accacggtcc gcctcccgct gcacgacgcg
    15481 ggcgcccggg ccggacggct cgccctcggc cgcgaggacg cgccgcccgg gggggtcgcc
    15541 accttccacg gcgacctcat ggtgcgcgac tccacggcgc cgccgcgccc ctgaaccgcg
    15601 tcagggcccc acccccacac ccgccaccgc gccccggcca ccacgaccgc accgacgaag
    15661 aggaaccgcc cgtacccggc gcccttccgc catcgcgccc cggccaccgc gaccgcatcg
    15721 gccaccgcga ccgcaccggg cacctccgac cgcgccccgc cacgcccccc gaccccaccc
    15781 ggcacccccg agcccgcccc accaccgcac cccgccgcac cccgccgcac ccggcacccg
    15841 gcacctccaa gggcgcctcc aacggcgcct cgccacggcc ggcacggccc ggcccgcagc
    15901 gccccgggac gcgcctgccc ggcgtcaccc gccccgcgcg ctcccgcgtc cactcatgcg
    15961 cccagggcct cacccccgtc ccgcggcccg cctgccgccc ccgggacgga acggccggga
    16021 cctgccccgg gcgggagcgg ccccggctcg gcaccgcccg ccgcgaccga ggcgcccccg
    16081 gggccgccgg ggcgcgcggc gcccgcgccc ctccggaggc cgccggaggg cgcgacggac
    16141 tccgcggact tgtggaagaa gctgctcgcc cgcagggtgc ccgccggatc ggccgcgtag
    16201 tcggggacct cgccgaactt cgtccagccc gccgaccggt acaggtgctc ggcggcactg
    16261 ccggtctccg tgtcgagcag cagcagcttc accccggact cccatgccgc ctgctcggcc
    16321 gtggcgagca atgccgcggc gacgccccga ccgcgcgccc cggggtggac catgagcttc
    16381 acgacctcgg cgcggtgccg tccgttcgcc tggggggccc ggaccagccc cgcggtgccg
    16441 accaggagac gccccacccg cgccgtccac accgtcaggc cgtcgccgca ggcgggggcg
    16501 cgggccgccc accaggccgc cgcctcctcg gcgccgaacg gcgcgacgaa accgatggag
    16561 gcgccgtcgg ccaccacgtc ggccagcagg acgcccagct cccgggcgtg cgccagcagg
    16621 ccctccgggg tgtcgagccg ggtgatctcg gtgctcacgg cagcaccgcc accacgacgt
    16681 accgggccgc ccctggcccg gggcagcggt acccggacgg cccccacagc cggaaccgca
    16741 ggcagtcgcc ctcccccagg gcgtgcgtct tctcccccac cgtgacctcg acggcgccgt
    16801 cgaggaccca cacatggtgt tcgaggccgg ggacgggcgg tgcctcatag gtgatgacgg
    16861 ctccctcccg cagccgcccc tccatcacct cgccgcgcag ccccgcgtgc ggcggcgaca
    16921 ccgaacggcg cacgaaaccg gtggccgcgt ccgtccacac ctcctggctg ccggccggca
    16981 ccggccccgg cggctcccgc tccacctcac tcagcagccg cgacatcgtc cgctcgtaga
    17041 ccgtgcacag cttgccgagc atggcggcgg tcgggctcat ctcggcccgc tccacgcgcg
    17101 acagcgtcga acggctgact ccgctgcgat cggccagctc ctccagtgac cagccccgct
    17161 cgctccgcag ctccgcgagc cggcccgcga gccgggcctc caccgagccc gccggcgggc
    17221 cggccactcc ctcactcaca tctcccatat ccgggatact atccctgatc cgggaaaacg
    17281 gaaggttctc ccggcggtct cccccggata tcccccgaac gagtgcacgg atcggcgacg
    17341 gcaccgggcg agcccgcgcg ggccgcggga gcccgccgtg agcccatcga gcccgcccga
    17401 gccggacgaa gacgagaggg ccgcgcgcgg tccgcgggcg caccggcgca gagcgctgcc
    17461 gcgcccccgc cccggcccgt ggcctccggg ccgacatggc tagggtcgcg ccatgggcac
    17521 ccagaaggaa cgcatgctcg cgggcgagct gtacatcgcc gacgaccccg agatcgccgc
    17581 ggacgccgcc cgggcgattc gcctgacgga ggagttcaac gccacggcca cggctgacgc
    17641 cgccacccgc agggccgccc tcgtcgcgct gctcggcgag gtcggcgagg gcaccgaggt
    17701 acgccccccg ctgcgcgtcg actacggcac ctacatcagc atcggccccc gcacgttcgt
    17761 caacaccggg gccgtcctcc tcgatgtcgc ccgcatcacc atcggcgccg acgtgcagat
    17821 cggcccgaac gtccagctgc tcacccccac ccatccggtc gagccaggac cgcgccgtga
    17881 gaaatgggag gccgcggcgc ccatcaccat cggcgacaac gtgtggctcg gcggcggcgt
    17941 catcgtctgc cccggtgtga ccatcggtga gaacaccgtg gtgggagcgg gtgccgtggt
    18001 cgtcaaggac ctgcccgcga acgtcgtcgc cgtgggcaat ccggcccgcg tcgtccggag
    18061 cgtgtaggcg gccgggcacg gtacggccgc cggtcgcggg gggcaacccc cgcggctacg
    18121 gttgaccgag agggccacag aaggcgggag gtgcgccacg tgacttccct ccgccgcggg
    18181 ggcaaaggcg gcgtgttcgc gctgctgctc gtctacctgg cgctgctcgc cgccctccag
    18241 atctggtcgg ggcgcaacaa cctcaccggc tggtcggggt tctcggtgct ggccccgatg
    18301 gtggcgggcg cgctgctgtc cctgcgcgac acgttcctcg tcggcctgct gacggtggcc
    18361 tccatcgtca tcgcgtacgg cggcaccatc cccggcctct cccccggcac ccgcgtcgtc
    18421 atctactcgg ccgcgatctg cgcgtccgcc ctcggcctcg tgatctgccg catccggctg
    18481 aaccgcgagg cccgcgtgag ccgcctgacc atcgcaaggg agcggctgac gctgctgcgc
    18541 gtggcgagcc ggcacgtcgg cagcacgctc gacgtacgac gcacggcgcg cgaggtcacc
    18601 gaggtcgcgg taccgggctt cgccgacctg gtcacggtcg acttgttcga ctcggtcctg
    18661 cgcggggacg agcctggcgg gccagacggc gtcgcgcggc gcctgcggcg cgtggcgcac
    18721 cgctcggcca ccggcgccgg cccgcgcgag ggcccgcggg accggggcga gggcgcgcgg
    18781 ccccagcgcg aggaccggtc cgcgcgcggg gagacggccg cccccaccga cgccgcggac
    18841 ccggccgagg cgaccgcgcc cgacgcgcgc gcccgcatcc tcgacgacgc cgaggtggcc
    18901 gcgtggctgg aggcgaaccc cgcgtgcgcg gccccgcgca cgcgcggcaa cggccgttcc
    18961 ggcatcgccg ttccgctgcg cgcccggggc accacgctgg ggatcgcgat gttcgtccgg
    19021 cacctgcgcg ccgacccctt cgacgccgac gacctcctgc tggccgagga gatcggcgcg
    19081 caggcggcgg tgtgcgtcga caacgcgcgc cgctacaccc acgagcaccg cgcctcgctc
    19141 accctccagc agagcctgct gccccggcgg ctgcccgagg tggcggccgt cgaggtggcc
    19201 acccgctacc tgccggcgga ctcgaccgcg ggcgtgggcg gcgactggtt cgacgtcatc
    19261 cagctctccg gcgcgcgggt ggccctcgtc gtcggcgacg tggtcgggca cggcctgtac
    19321 gcctcggcga ccatgggacg gctgcggtcc gcggtgcgca cgctcgcgga catcgacctg
    19381 gcgcccgacg aactgctcac ccacctcgac gacgtcgtca tccggctgcg ttccgagacc
    19441 gaggggaacg acccggaaca gacgggcgag ggcaccgcgg agagcccggc cggcgcggtc
    19501 ggcgccacct gcctgtacgc cgtttacgac ccggcgtccc gcgtctgcac catggcgcgc
    19561 gccgggcacc ccgcgcccgc gctggtgcgg ccggacgggc gggcggagtt cgtggacgcg
    19621 cccgccgggc agccgctcgg cctcggcggg ctgccgttcg aggcgcacga ggtcctgctt
    19681 cccgagggca gctacctcgc gctctacacc aacgggctca tcgcccgcga acacgacatg
    19741 gaacgcggcc aggcgacgct ccgacaggcc ctgtcccggc ccgccccctc cgccgacgcg
    19801 gtctgcgaga cggtgctcgg ggcgatgctg gacgacgggc agacggacga catcgcgctc
    19861 ctcgtggccc gtacccgtgc cctcgacgcg gcgcacgtcg ccacgtggaa catccccgac
    19921 gaccccaccg ccgtcgccca tgcgcgtgaa ctcgccgacc ggcagttgac cgtttgggga
    19981 ctgccggacg cggccttcac cacggaactc gtcgtcagcg agctggtcac caacgccatc
    20041 aggcatgccg acgggccgat ccagttgcgc ctcatccggg agccctccgc cctgatctgc
    20101 gaggtctcgg acaacagcag cacctcgccc cacctgcgcc gggcccgggc cttggacgag
    20161 agcgggcgcg ggctgttcat cgtcgcgcac ctgaccgcgc ggtggggcac caggcacggg
    20221 cgggagggga agaccatctg ggccgagctg tcgccgactc cttcccccga cgcgctgctc
    20281 gccgccggct gaacggcgcg acggccggcg gagcggcgcg acggcgcgac gggaacggac
    20341 cggagcggcc gggacgcacc aggacggggc gcgttgtcgg aggcggcgcc taggctgccg
    20401 ccatgaccga ctccgcccca ccgctcgcct cgggaccgct cggcatgcgg ctgctcgcgt
    20461 tcgaccgcgt gcccgaggac acgcgcttcg acgacggcgt ccccgtgggc tacagcctgg
    20521 tggccctgtg gcgcgccggg ctgctgctcc tggtccacgt gcgcggccgg gactgctggg
    20581 agctgcccgg cggcgggctc gaccccgacg agacgccgcg tcaggccgcg gcgcgcgagc
    20641 tggcggagga gtcggggcag cacgtggcgc cgcggcggct gcgcttcgcc gggttcgcgc
    20701 tgacctcgct gccgggccgc ggcgtgctgc gcggcgcggt ctaccgcgcg gagacggacg
    20761 cggcggagcc gttcgccccg acggcggaga tatcgggcgt ccactggtgg gacggggccg
    20821 gcccgttgcc gcacggccgc ctccagacgg tcgacgcccg cctcgcggag ctggtcggcc
    20881 gctgaccggt ggcgccggct cgcgtccggc ggtcgccgcg ttccctcaga ggcgccggac
    20941 gcggttggcc acggcgtggc cgacgacgag gtacaccacg gccgcgagcc cgtagccgca
    21001 gacgacgcgc gcccactcct cgtcgaacgt gaacaggtcg tgcgaccagg tggccagcca
    21061 gcgggacacg tcgtggatga actcgaccag tccgttctgc tcgttggcgt cgagaaggta
    21121 caggacgatc cacaggccga tgatgaacgc ggcgacgtcc gcgatcacgg tgatcacggc
    21181 cgccgtcggc ccga
//
