LOCUS       NZ_CP021121            21718 bp    DNA     linear   CON 31-JUL-2024
DEFINITION  Streptomyces marincola strain SCSIO 03032 chromosome, complete
            genome.
ACCESSION   NZ_CP021121
VERSION     NZ_CP021121.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces marincola
  ORGANISM  Streptomyces marincola
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6287975)
  AUTHORS   Ma,L., Zhu,Y., Zhang,W., Zhang,G., Tian,X., Zhang,S. and Zhang,C.
  TITLE     Complete genome sequence of Streptomyces sp. SCSIO 03032 revealed
            the diverse biosynthetic pathways for its bioactive secondary
            metabolites
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6287975)
  AUTHORS   Ma,L., Zhu,Y., Zhang,W., Zhang,G., Tian,X., Zhang,S. and Zhang,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2017) Key Laboratory of Tropical Marine
            Bio-resources and Ecology, South China Sea Institute of Oceanology,
            164 West Xingang Rd., Guangzhou, Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method :: Hierarchical Genome Assembly Process v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 165.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002128305.1-RS_2024_07_31
            Annotation Date                   :: 07/31/2024 06:55:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,513
            CDSs (total)                      :: 5,438
            Genes (coding)                    :: 5,343
            CDSs (with protein)               :: 5,343
            Genes (RNA)                       :: 75
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 95
            CDSs (without protein)            :: 95
            Pseudo Genes (ambiguous residues) :: 0 of 95
            Pseudo Genes (frameshifted)       :: 19 of 95
            Pseudo Genes (incomplete)         :: 88 of 95
            Pseudo Genes (internal stop)      :: 2 of 95
            Pseudo Genes (multiple problems)  :: 13 of 95
            CRISPR Arrays                     :: 12
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:29:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 270725
            Orig. end                         :: 292443
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP021121.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Key Laboratory of Tropical
            Marine Bio-resources and Ecology.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21718
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="AfsA"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..21718
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="neighbouring"
                     /product="butyrolactone"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..10942
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10942
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5942](+)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5942
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     gene            complement(307..1281)
                     /locus_tag="CAG99_RS00870"
                     /old_locus_tag="CAG99_00870"
     CDS             complement(307..1281)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009334105.1"
                     /locus_tag="CAG99_RS00870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_00870"
                     /product="phosphotransferase family protein"
                     /protein_id="WP_086157092.1"
                     /sec_met_domain="APH (E-value: 7.4e-11, bitscore: 40.7,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHERLAGAARAALGGGRRLAAVERVAGGTKKGVYRLVMDDATTA
                     IAYVWDEAENHWPTSEGDDDLTDPFSPGLGLDLFEAAHGRLGALGVRVPAIRFVDRVDA
                     HGPADLAIVEDIPGESLEELLARDPDAAAPVMDRLAESLEAMRGHRASAYGKVAVVDAG
                     GTSRGTSCEGVVLDRALRDLAEAASRDPRIAGARDRLEKRLLGLAAAVRPRTEYAVVHG
                     ELGPDHVLVDAEGNPVVIDIEGLMYFDVEWEHVFLHIRLHDAYRPLRVDGLDEDRLALY
                     MLAQRLSLTAGPLRLLDGDFPDRAVMADIAEYNLKQALELVHR"
     misc_feature    1264..1277
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.03"
                     /tool="antismash"
     gene            complement(1575..1898)
                     /locus_tag="CAG99_RS00875"
                     /old_locus_tag="CAG99_00875"
     CDS             complement(1575..1898)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019354960.1"
                     /locus_tag="CAG99_RS00875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_00875"
                     /product="multidrug efflux SMR transporter"
                     /protein_id="WP_086157093.1"
                     /transl_table=11
                     /translation="MSWLLLIAAALVEVAWSQSIKPTAGFTRPLPTLVCFALAAVAVYL
                     LSLAMLELPVGTAYAVFTGIGAAGAVTLGVIVHKDPVTVGRVLALTLIVGGVALARATA
                     PDT"
     gene            complement(1895..2560)
                     /locus_tag="CAG99_RS00880"
                     /old_locus_tag="CAG99_00880"
     CDS             complement(1895..2560)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018521619.1"
                     /locus_tag="CAG99_RS00880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_00880"
                     /product="FMN-dependent NADH-azoreductase"
                     /protein_id="WP_086157094.1"
                     /transl_table=11
                     /translation="MPTAAPTLLRIDSSARRTSFSREIGDAVADAWRRAHPDGTYLRRD
                     LALTPVPQIGEAWTELCDYVLAHQITEISRYKEAVRSQDQAAAWAIVEPLLTELVAADT
                     VLIVAPMYNYSVPASLKAWIDQVAFPKMSLAGRRFVVAYARGGAYGPGTPRHSCDYQER
                     YLRDFFAGHFAVPHEAMTFLGTELVNSRVDPALADRREAHETSRADALAAARMLGGAL"
     gene            2673..3230
                     /locus_tag="CAG99_RS00885"
                     /old_locus_tag="CAG99_00885"
     CDS             2673..3230
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018521618.1"
                     /locus_tag="CAG99_RS00885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_00885"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_086157095.1"
                     /transl_table=11
                     /translation="METRERADAARNRARVLSAAARLFAEGDPRTVTMEDIARAAGVGR
                     GTLYRRYPDVSSIAAALLDEHERLLQGELLRGAPPLGPGAPPHERLAAFLSAMVDLLDR
                     HSHLALGAEAGAKRFAVGAYGFWRAHVLALLRQAGTPDPEALADIVLAPLASEHFLHQR
                     AQGVTTDRIKAALTRLAHVTTA"
     gene            complement(3671..4018)
                     /locus_tag="CAG99_RS00890"
                     /old_locus_tag="CAG99_00890"
     CDS             complement(3671..4018)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389900.1"
                     /locus_tag="CAG99_RS00890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_00890"
                     /product="plasmid stabilization protein"
                     /protein_id="WP_086157096.1"
                     /transl_table=11
                     /translation="MPKGSTSKQERQYEHIKKGAKERGASTGRAKEIAARTVNKERARS
                     GQAASASRSSTRGDSPSRRGGKAWGGGRAQGGGAKGGTATRDELYEQAKRRDIRGRSSM
                     TKQQLAEALGR"
     gene            complement(4146..4793)
                     /locus_tag="CAG99_RS00895"
                     /old_locus_tag="CAG99_00895"
     CDS             complement(4146..4793)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003970700.1"
                     /locus_tag="CAG99_RS00895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_00895"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_086157097.1"
                     /transl_table=11
                     /translation="MARQDRAIRTRRICLEAAAEVFDECGYEGASIAAILERAGLTRGA
                     LYFHFSSKEELARGVLAEAVTAEGVMPQPLKLQEWVDTALLLAYRLPREPVLSASIRLS
                     ADPRARGLLGTRWPDWIALGRDMIAEAKARGEVMPHVDPLVASRVTVASWTGVQLVSGS
                     QADAPALVDDIVALFALLLPGIAVPAILTRLEVSAERPARLLAQAGPAAPAD"
     gene            5001..5942
                     /locus_tag="CAG99_RS00900"
                     /old_locus_tag="CAG99_00900"
     CDS             5001..5942
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014047021.1"
                     /locus_tag="CAG99_RS00900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_00900"
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_086157098.1"
                     /sec_met_domain="AfsA (E-value: 4.6e-16, bitscore: 57.0,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHLHLTREDNVLVTGYARLGPHTFLLSGRWPRDGAVAADDPRVL
                     TQVVRQSGLAVAHAEYGVPLHHRTLLHSLDFSFAPAPHAAARPAAPLLIEADVLGAPRP
                     GRTLRSLAMAVRLMRDGVAVVEARARFGWVSPAVYRRLRGDRLAPARMWGAGPVPAPAA
                     PGTVGRARRENVVLAPGPGPRVWRLRADMTDTLLFDHPVDHVPGLVLVEAALQAAHAHA
                     PGLGISTVACDYERFAELDTPCWIVSRAERPPRPDGRTVIEVEGTQGGRPVFRVAVDGT
                     LPAAGAAAPPPATRTGAPAPLAARDVAACALP"
     gene            complement(6011..7903)
                     /locus_tag="CAG99_RS00905"
                     /old_locus_tag="CAG99_00905"
     CDS             complement(6011..7903)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF027688.4"
                     /locus_tag="CAG99_RS00905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_00905"
                     /product="calcineurin-like phosphoesterase family protein"
                     /protein_id="WP_086157099.1"
                     /transl_table=11
                     /translation="MLSFPARKHSSLRIALTAFTTLAVAGGLVAIPTTASTATPGPAPA
                     SWDENAYRGQVEVVRTPEGPADPDHLTGRVFVDRDRDSVHDRGERGLPGVVVSNGRDVV
                     TTDRHGRYRLPVYDNMTVFITQPSGYQVPVDESNVAQFHWNHLPEGSPELRYGGIAPTG
                     PLPDAVNFPLVRSQLTRAQEQHCVIAGDLQTYDRTEVEYARRGAISDLAGRRDYQGCGT
                     LFIGDVVGDDLSLYPDVKELTSLTNGPARFLPGNHDLDFDSATAEHAFDTFRAQLAPAY
                     YSYDVGDVHVVALNTVRYPCTPDVDNADGLRPQCDDPENSPRYNGRLDEHQLAWLERDL
                     AAVDEDKLVVIAGHIPLLTFADEGSPIHQVDQVRDIYALLEGREAVSVAGHTHSIENMR
                     TGDLMRGWQDLFGVEGLPFPHITAGAISGDWYSGELTEHGYPAAVGRDGGRPGLLTLDI
                     RGDSFRERYTVTGESDRVQTQLGINSPTYRDWYAERQAWNDDPQGPAPELGDPHVVTRA
                     DLAGQTWLTTNFWMGSTGSTVEVRIDGGRSREAVRTQPMRGEDQLIGPEWSDPHAVAQQ
                     LVHGGSVADRTMHLWRFELPADLDAGRHRAEVTATDVHGREYTDVLHFRVVEQP"
     misc_feature    7895..7909
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 23.03"
                     /tool="antismash"
     gene            complement(8165..8791)
                     /locus_tag="CAG99_RS00910"
                     /old_locus_tag="CAG99_00910"
     CDS             complement(8165..8791)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1116:
                     Homoserine/threonine efflux protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018838877.1"
                     /locus_tag="CAG99_RS00910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_00910"
                     /product="LysE family translocator"
                     /protein_id="WP_086157100.1"
                     /transl_table=11
                     /translation="MVDSSLYAAFLVAALALCVTPGPDMMFIVAMGGRGGPAAGVMAAL
                     GVAGAMCVHAVAATLGLSALFTALPALYHVLRWAGAAYLLYLAVKAFRDRGPLGSGDEN
                     TGPGYRRAFWQGAVINLLNPKVILFNVAFLPQFVDPGRGQVPAQLLTLGITIVVIGLCV
                     DGTVGLLSGRLAMLLRRSRRVARGLSIFSGTVFAGLAIRLVASPR"
     gene            9109..10137
                     /locus_tag="CAG99_RS00915"
                     /old_locus_tag="CAG99_00915"
     CDS             9109..10137
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018384455.1"
                     /locus_tag="CAG99_RS00915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_00915"
                     /product="transcriptional regulator"
                     /protein_id="WP_086157101.1"
                     /transl_table=11
                     /translation="MGPSRRGVLRTGLYSVALTVPGRPEIVDRVQAFRGGRLSRIGMGE
                     VAVVTAMTRRIQELDDQFGTRHARPLAANFLVNTAVPYLRADADENVRAALLSATARLC
                     HLTGYMAVDEGLHGLAQRYYVKALEFADAADDRFAYSGTLRGMSVQATDLGHAATALRL
                     ADAAAEGAHGAPQPRRAFFAGQQAHAAQTGDRQTALRHLATAERAMSRADLGGAAFASY
                     DPAALNDHVSQVRWELGDIAGAVASLRASNRGLHVGYQRTTVRRRFMLAERYLRLGHLD
                     VACATWARALDDYPGIDSGRVDERVAAMKALLRPHRGNGAARAVLARADTPARARGAAG
                     VP"
     cand_cluster    9766..21718
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    9766..21718
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[14765:16718](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      14766..16718
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
     gene            10266..10964
                     /locus_tag="CAG99_RS00920"
                     /old_locus_tag="CAG99_00920"
     CDS             10266..10964
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.4"
                     /locus_tag="CAG99_RS00920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_00920"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_086157102.1"
                     /transl_table=11
                     /translation="MPEAAYDEIADWYETEFTAGQRYGAAHADPLGLDALIRDLLGAGS
                     GPCLEIGCGTGVHAGRVRDLGWTPVGVDLSGGMLRHARGRLPVARADAARLPVRDASVS
                     AVLSVMVHTDMPDYSAVVREAARVLRPGGALTHIGVHPCFCGAFADRRDAEAVVIRPGY
                     RESHWSRESWTDQGVRDKVGASHLPLPALLGAFTAAGLVLDRFAEGGGPTPVVFGLRAV
                     RPADGAVARP"
     gene            11452..12732
                     /locus_tag="CAG99_RS00925"
                     /old_locus_tag="CAG99_00925"
     CDS             11452..12732
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF017760.4"
                     /locus_tag="CAG99_RS00925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_00925"
                     /product="MFS transporter"
                     /protein_id="WP_086157103.1"
                     /transl_table=11
                     /translation="MTRAHSENTNSSRDFRLLWTASAADSLGTQTSGVVLPLLLLAAGH
                     SATVAGAVVSVSLLAGLLAGPFAAVLADRGGRRTVMAWSALTAGAAMAVVALLAASARP
                     PLGALLAAVTAERVATSAYAAAAQGCVAALVPPAAYPRAVSRLQAGEQGALVAGPVLGG
                     LLFQAARWLPFLVDALTYLVAVLCVRSIRADLSPGAAREPGRRGVGAVFADLRDGLRFV
                     RGESFLRGVLWWMTGVNGVLAALYYGAVFALERHGAGTAAIGTVLAVSGAAGVVGALLA
                     PRLAARIPAARLAVLVSWAVVLVALGLTAATRPWSYGLLFAVVSLLVPTLAVLLAAQAI
                     AVTPAAFQSRVGTVLNTVSGVAATAAPLAAGALVALAGTTGLALAGAGTMAVVAVYASR
                     VVAPGLRAAAARPSGAAAAPAGREATP"
     misc_feature    11471..11484
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.32"
                     /tool="antismash"
     misc_feature    complement(11471..11485)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.16"
                     /tool="antismash"
     gene            12729..14573
                     /locus_tag="CAG99_RS00930"
                     /old_locus_tag="CAG99_00930"
     CDS             12729..14573
                     /EC_number="3.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010359085.1"
                     /locus_tag="CAG99_RS00930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_00930"
                     /product="S9 family peptidase"
                     /protein_id="WP_255307908.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 7e-32, bitscore:
                     108.9, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAGAAGPAPERRAYAVSRPVLPAVCRDAPELMAFAGDADGRCEI
                     FAWHAGTGERRQVTDRPEGTVRCAIDPDGVIWWFAERADGTGTWLTQDFAGGADVPAFG
                     GEPARGRPAGLALPGGTAAAGLLDADRLTVRVGRRGELPRHTLRFDGQARLAGFAPAAG
                     LLAVARAPGHERAVTLHTVDGGTVAVLPGRGGRIWPLGFAPERGGGPGVAAGEPASGGT
                     ELLLVREDEDGYRLATWTPEGGLLAHAWCAFDTEITAQWVPGGREVLVRQERHGRSLLA
                     LCDLTARTRRPVPVPEGTVLDAAADAGGAVHCLWTDTRTPARVLTAGTAARLLPPPPPE
                     PPPLEAEVSDLWTPGEDGPVHTLLAMPPGRTGPGPVVFLVHGGPARHDKDAYDPAVHSL
                     VASGLAVARVNYRGSTGYGPRWRAAWGRGVGLTQVEDLAAVRADLVDRGIADPGATGLW
                     GTSWGGYLVLLALGCRPGLWRAGVAVKPVADYAAAWALGTPELRALDTALFGGTPDEVP
                     GRYARSSPVTYVAGVRAPLLVIAATRDAKCPPEQVRGYLAALRAAGGTCRELWLDSGHD
                     GHDGAGHVRVLRHSLHFLARELRASRAGVPAPRDDGGR"
     gene            14579..14701
                     /locus_tag="CAG99_RS28640"
     CDS             14579..14701
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CAG99_RS28640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_255307909.1"
                     /transl_table=11
                     /translation="MEKDVIQNDPLEHEAEGRSPAVTVTITVPLMTPEDEDLDV"
     gene            14766..16718
                     /locus_tag="CAG99_RS00935"
                     /old_locus_tag="CAG99_00935"
     CDS             14766..16718
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03975"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019357532.1"
                     /locus_tag="CAG99_RS00935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_00935"
                     /product="RiPP maturation radical SAM C-methyltransferase"
                     /protein_id="WP_086157104.1"
                     /sec_met_domain="TIGR03975 (E-value: 2.1e-174, bitscore:
                     579.6, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLLINMPWSPIDLPSLALGILTRSVNEKVPGARAEVLHGNLDY
                     FDWLTARPGFADFTADDYAYYALSSYFLGCGDWVFSSALYDDPEWRVTEFSEAMRRPVG
                     ARRLAQAVELHRGAPEFVRELAMRVVAQKPDVVGFTSTFQQNTAALAAARMIKELAPGT
                     VTVMGGANCDSAQGEATHRNFPFVDYVVRGEGEVAFPALLNALREGTGLAGIPGLCWRD
                     GDASRANPMATAPLPPAAIVSPDYRGYLDRLAASAARHMIEPKLVIEGARGCWWGEKHH
                     CTFCGLNGSFMQFRSKSPDAFFDEIVGMAREHRVLDMYIVDNILDMGYVTTLLPRLIET
                     GYDLRMHVEIKANMRREQLKTLADAGLVFVQPGIESLNTRVLGLMDKGVSGCQNVRMLR
                     DGASTGLSVSWNYLYGFPEERESDYEPVIAQMPALEHLNPPTGLSARIAIERFSPYFNR
                     PELGFSELRAAKPYWLTYDLPEQELYDLAYIFDAPQRGIGAATAKRLNEALSAWMDANA
                     TSRLVGHDLGERLVLLNRRRAFPWTTLVVDDPLELAAFRLLEQPRSPRTLVRKLGELFP
                     GADAEALVPPLLERWSDLGLLFTDAGQYVHVVPAPVNDEMLRLGFMRGVVADAAAPPPE
                     AAARDTGRTPAALPA"
     gene            16732..17382
                     /locus_tag="CAG99_RS00940"
                     /old_locus_tag="CAG99_00940"
     CDS             16732..17382
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003958122.1"
                     /locus_tag="CAG99_RS00940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_00940"
                     /product="DUF5825 family protein"
                     /protein_id="WP_086157105.1"
                     /transl_table=11
                     /translation="MTVSTSPPAVRAWRDYDARALETPGMFLGEVPLSGPTDALVDRLW
                     DLGARRVELPGRVDLADPGDPEGTVRALGLVRDLTAQAVYTQWRLRLPASAPDWVPFCH
                     LQPPAVLEGVPDAGAVLARWRETHYLGKCQWRRGPGFFQLRDRRWGDLRRFTLTDDAYL
                     AAVETLVPGARADDVPTPVLAAFEAEKLAWRVGDRVAWLPYATRRWAQSAMLI"
     gene            complement(17488..19002)
                     /locus_tag="CAG99_RS00945"
                     /old_locus_tag="CAG99_00945"
     CDS             complement(17488..19002)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014172754.1"
                     /locus_tag="CAG99_RS00945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_00945"
                     /product="VWA domain-containing protein"
                     /protein_id="WP_086157106.1"
                     /transl_table=11
                     /translation="MSGTPNGPGVPPGPAGPPGAAPERHTAAVVADRFDRITWRDTCEQ
                     SAALRALAAELGARHAGAADLMADVFLAAYQTRPRLRDRREMAPARLVNHRIVGSLVAA
                     PHFADLHRETAGDPYAAAMAVLAQAAALRGMLERSRAAQEQADRAAAAERAAEAAGPTA
                     DAPADRVARQAAEAAGRALAAAAPGLDAAARNAAGRAARAARHEAALMRAWGLGPGDLE
                     RMPFDRRARLAERLGTGRFARWAELIGRFRQMAAGEHARAVESTAGELVGVTLGDDLSR
                     VIPSELAHLGLPATRAVFAARYAAGELMLYDTRAERPAGRGAVIACVDTSHSMYAAGPG
                     GVTREAWAKACALALLDQARRAGRDFVGILFSSADRTRIFRFPAGAPAGIDQVLDFAET
                     FLGGGTSYQTPLTAARDLLADEFDAAARTRGDIVMITDDECDVTQEWLRDWREAERRLA
                     FRVFGVSIGAPGAVAAGSVLDVLCDNVRSIEDLTDVHAAADLFRVI"
     gene            complement(19020..20219)
                     /locus_tag="CAG99_RS00950"
                     /old_locus_tag="CAG99_00950"
     CDS             complement(19020..20219)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044132.1"
                     /locus_tag="CAG99_RS00950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_00950"
                     /product="AAA family ATPase"
                     /protein_id="WP_086157107.1"
                     /transl_table=11
                     /translation="MDAQGTRDTAARLRSICDELSERFLERADVVRTLVVTLLAGQHSL
                     LLGPPGTAKSELARELTGRIDGAAYWEILLSKFTAPTRMFGPIDVAALARGEYRQIYEG
                     RATTAHVAFIDEIFKCSTAALNETLGFLNERIYHPESGGEPIRCPLIGAITASNELPAA
                     EDTAAIYDRLLVRIEVGYLADPSNFAALVRSAVDRPVARRRTTVELAALRHAVTEAVPA
                     VDVPDPVVDAVCTLRAALRRREIVASDRRWRQAVGLLQASAHLDGRQAVAVTDLSVLTH
                     VLWNAPAERPAVEREVLLVVNPDAGEALDLADAIEELEAQLDAMAGQSREALSEWVIKK
                     AHNKLATAGRRLAELRAEAASAGRSTTAIDRITGRQRAVRARVLTEALGVDASMVQERL
                     "
     gene            complement(20459..21358)
                     /locus_tag="CAG99_RS00955"
                     /old_locus_tag="CAG99_00955"
     CDS             complement(20459..21358)
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012999171.1"
                     /locus_tag="CAG99_RS00955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CAG99_00955"
                     /product="helix-turn-helix domain-containing GNAT family
                     N-acetyltransferase"
                     /protein_id="WP_086157108.1"
                     /transl_table=11
                     /translation="MDAAQIDRVRRFNRAVTARLGVLHDHYLGRDRPVGEARLLWEIGE
                     DGQDVRRLRESLGLDSGYLSRLLRSLQADGLVTVEPHARDRRVRTARLTAAGRAERRVL
                     DDRSDELAGALLAPLNPAARDRLVAAMAEVERLLTAATVRIDAVDPGHPDAAHCLRAYA
                     AELAERLDTGFDPALSLLPDAGGLKPPRGLFLVARLNGEPVGCAGLRLPAGAPAEIKRM
                     WVAPGSRGLGLARRLLAELEAAAVRHGHDLLRLDTNRALDAAVALYRACGFHEVPAFND
                     ERYAHHWFEKRIGPKAAE"
     misc_feature    complement(21356..21370)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.39"
                     /tool="antismash"
     misc_feature    complement(21491..21504)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.4"
                     /tool="antismash"
ORIGIN
        1 aggcgatccg cgcgagttcg gccgcgtcca ccgtcccgtc gagtcgtgac tcgatgtgct
       61 ccatggcctc gttgagccgg tcaagcaccg gtgctccttc cctctgacgc ctcccacgct
      121 aggcagcgcg cccttaccgg cgcccgacat tccatgcccg cgccgatcgg gtcgcccggc
      181 ccccgcgacg cggggtggca ggggaccagc ggggacgagg cggcgcccgc ccttcgtggg
      241 cccgggcccc gcaccggccc gtgccccctg gccggttccg gcgcacgcgt cgaggcaccc
      301 ggacgttcag cggtggacga gttccagcgc ctgcttcagg ttgtactcgg cgatgtccgc
      361 catgacggcc cggtcgggga agtccccgtc gagcagccgc aggggccccg ccgtgagcga
      421 gaggcgctgc gccagcatgt agagcgcgag ccggtcctcg tccaacccgt ccacccgcag
      481 cggccggtag gcatcgtgca ggcggatgtg cagaaaaacg tgctcccact cgacatcgaa
      541 gtacatcaat ccctcgatat cgatcaccac ggggttgcct tccgcgtcca ccaggacgtg
      601 atccggcccc agttcgccgt gcacgaccgc gtactccgtg cgcggccgta ccgccgccgc
      661 caggcccagc agtcgcttct caagccggtc gcgggcgccc gcgatccgcg ggtcgcgtga
      721 ggccgcctcg gcgaggtccc gcagcgcacg gtcgaggacc accccctcgc acgacgtgcc
      781 gcgcgacgtt ccgcccgcgt cgaccacggc caccttgccg tacgccgatg cccggtggcc
      841 tcgcatcgcc tcaagcgact ccgcgagccg gtccatgacc ggagcagccg cgtccgggtc
      901 gcgcgcgagc aactcctcca ggctctcgcc cgggatgtcc tcgacgatcg cgagatccgc
      961 cgggccgtgg gcgtcgacgc ggtcgacgaa acggatcgcc ggcacgcgga cgccgagcgc
     1021 gcccaaccgc ccgtgcgcgg cctcgaacag atcgagcccg aggccgggcg agaacgggtc
     1081 ggtgaggtcg tcgtcgccct cggacgtcgg ccagtggttc tcggcctcgt cccacacgta
     1141 ggcgatcgcc gtcgtcgcgt cgtccatcac caggcggtac acgcccttct tggtgccgcc
     1201 cgcgacccgc tcgaccgccg ccaaccgccg ccctccgccc aacgcggccc gcgccgcacc
     1261 ggccaaccgc tcgtgtgtca tcgacctggt cgccacgccc ggaaccgccc cttctccatc
     1321 gcaaccagcg caccctacgg gagcaccggc acgggagcga tcggtttttc cggacgcgac
     1381 gcccacccac catccggcct ccgaggccgt cgccgtcctt cgcgtcacgg tgtgcgaccg
     1441 ttcccgtgcg gcgggggggt accggcatcc ggccgccggg cgactcaccg ccggctcaac
     1501 ggccgccgag ccgctggggg gcgccgctgc cgagcagggc gtcgacgcgg gcgcatgcag
     1561 cggacctccg gtcgtcaggt gtccggggcg gtcgcgcggg ccagggccac gcccccgacg
     1621 atcagagtga gcgcgaggac gcgccccacg gtcacggggt ccttgtgcac gatgacgccg
     1681 agagtgacgg cgccggcggc gccgataccc gtgaacacgg cataggccgt accgaccggc
     1741 agctccagca tcgccaggga caacaggtag acagcgacgg cggcgagcgc gaagcacacc
     1801 agcgtcggca gcgggcgggt gaagcccgcc gtgggcttga tgctctgcga ccaggcgacc
     1861 tcgaccaggg ccgcggcgat gagcagcagc cagctcacag ggctcctccg agcatcctgg
     1921 ccgccgccag tgcgtccgcg cgggacgttt cgtgggcctc acggcgatcg gcgagtgcgg
     1981 ggtcgacgcg ggagttgacc agttcggtgc cgaggaaggt catcgcctcg tgcgggacgg
     2041 cgaagtgccc ggcgaagaag tcacgcaggt agcgctcctg gtagtcgcag gagtggcgcg
     2101 gagtaccggg cccgtaggcc ccgccccggg cataggccac cacgaagcgc cgtccggcca
     2161 gggacatctt cgggaaagcc acctggtcga tccacgcctt gagcgacgcg gggacggagt
     2221 agttgtacat gggggcgacg atgaggacgg tgtcggcggc cacgagctcg gtcagcagcg
     2281 gctcgacgat cgcccaggcc gcggcctggt cctggctgcg caccgcttcc ttgtaccggg
     2341 agatctcggt gatttggtgc gccaggacgt agtcgcacag ctcggtccag gcttcgccta
     2401 tctgggggac cggagtgagc gcgaggtcgc gccggaggta ggtgccgtcg ggatgggcgc
     2461 gacgccaggc atccgcgacg gcgtcaccga tctctcggct gaaggaggtg cggcgggcgc
     2521 tggagtcgat gcgcagcagg gtcggtgcgg cagtgggcac ggcggatctc ctgttcgggc
     2581 gacacaaccg gacgcggcgt ccagttatgg ggcgacccta tcaaccggac agcgcgtccg
     2641 gttattccgg gggccggcgt agactcgtcc gcgtggagac gagggaacgc gcggacgcgg
     2701 cacgcaaccg agccagggtg ctctccgcgg cggcccggct gttcgccgag ggcgatcccc
     2761 gcacggtcac gatggaggac atcgcccgcg ccgccggcgt cggacggggc accctctacc
     2821 gccgctaccc ggacgtgtca tccatcgcgg cggcgctgct cgacgaacac gaacggctgc
     2881 tccagggcga gctgttgcgc ggcgccccgc cgctgggccc cggagcgccg ccgcacgaac
     2941 ggctcgccgc cttcctctcg gccatggtcg acctgctcga ccggcacagc cacctcgccc
     3001 tcggggccga ggccggggcc aagcgcttcg cggtcggcgc ctacggcttc tggcgcgctc
     3061 acgttctcgc gcttcttcgc caggccggca cccctgatcc cgaagccctc gcggacatcg
     3121 tgctcgcgcc cctcgcgtcc gagcacttcc tccaccagcg cgcccagggg gtgacgaccg
     3181 accgcatcaa ggccgcgctc acccggctcg cgcacgtgac cacggcatga ccaggcgcgc
     3241 cggtcagctc gggcagccgt gcccgccctc gccctcgcga agggcttgaa cgctcggcgc
     3301 ccgtcgcgcc tccctccagc ggcggcctgg cggcggtgtg cgccgccgag gcgcacgggc
     3361 cggtcaacgc ccgccgaccg gctcacgcgc cctgagccgc cgcagcgcct cagggccgcc
     3421 gcctcagcgg cggctcgggc gccggggcgc cgccccggct ccggcacgaa cggggctgcg
     3481 cctggctgcc gtcaccgatg cggctcggcc cagtcggcag ctcccgggag gcgccgcacg
     3541 ccgaccgggg ccgcgggcga cctgtcggcc gccgagtgcg ccgcggccgg cggcccgttc
     3601 cgggtcagcg tccgccgatg tccggagtac gggccccggc gggccgggcg gcgcggcccg
     3661 tgggcgtgcg tcagcggccg agcgcctcgg ccagctgctg cttggtcatg gaggaacggc
     3721 cccggatgtc gcgccgcttc gcctgctcgt acagctcgtc gcgcgtcgcc gttcccccct
     3781 tcgcgccacc gccttgcgcg cgcccgccgc cccacgcctt gccgccgcgc cgggagggcg
     3841 agtcgccgcg ggtggaggag cggctggccg aggccgcctg ccccgagcgc gcccgctcct
     3901 tgttcaccgt gcgggcggcg atctccttgg cacgccccgt ggaggcgccg cgctccttgg
     3961 cgcccttctt gatgtgttcg tactgacgtt cctgcttgga ggtcgatccc ttgggcatcg
     4021 ccacgactcc ctcgctggtc ctgcgtcttg ccgttccggc cgcccgcgga cggcgcgttc
     4081 cggccgggtg cccggcgacc ggaggcggga aacgggcccg gtcggccggg atgcggcgcg
     4141 gccggtcagt cggcgggagc ggcaggtccg gcctgcgcga gcaaccgcgc cggccgttcg
     4201 gccgacacct caagcctggt gaggatcgca ggcaccgcga taccgggcag cagcagcgcg
     4261 aacagcgcga cgatgtcgtc gaccagcgcg ggcgcgtcgg cttgcgagcc gctgaccagc
     4321 tggacaccgg tccaggaggc gaccgtcacc cgggaggcga ccagcgggtc gacatgcggc
     4381 atgacctcgc ccctggcctt cgcctcggcg atcatgtcgc gccccagcgc tatccagtcg
     4441 ggccaccggg tgccgagcag gccccgcgcc ctcggatcgg cggacagccg gatggaggcg
     4501 ctgagcacgg gctccctggg caggcggtag gcgagcagca gggcggtgtc cacccactcc
     4561 tgcaacttca gcggctgcgg catgaccccc tcggcggtca cggcctcggc gagcacgccg
     4621 cgcgccagct cctccttgga ggagaagtgg aagtacaggg caccgcgcgt cagccccgcc
     4681 cgctccagga tcgcggcgat ggacgcgccc tcgtagccgc actcgtcgaa gacctcggcg
     4741 gccgcctcca ggcagatccg ccgcgtgcgg atggcccggt cctgtctcgc caactggctc
     4801 ccccctgggc cgttttacct gctccttgca caataccgga gaaccggtat cttatcagtg
     4861 ccgcttcgcc gtccggattg tccttggggg aagtcgtcgt ggatcaggcc ccgttaactc
     4921 tgcgcgcgtt gtccggccca cccgcacccc gccgaagacc cgagccgcgc ggcgccgccc
     4981 cggcgacgag ggcggtgccg atggagcacc tgcatctcac gcgcgaggac aacgttctgg
     5041 tcaccgggta cgcacgcctc gggccccaca cgttcctgct gtccgggcgg tggccgcgtg
     5101 acggcgcggt cgcggccgac gatccgaggg tcctcacgca ggtggtccgg cagagcgggc
     5161 tcgccgtcgc ccacgccgag tacggcgttc ccctgcacca ccggacgctg ctgcactcgc
     5221 tcgacttctc cttcgcgccg gcgccgcacg cggccgcccg cccggccgcc cccctgctga
     5281 tcgaggcgga cgtgctcggg gcaccgcggc ccggccggac gctgaggtcg ctggccatgg
     5341 cggtcaggct catgcgggac ggcgtggccg tcgtggaggc gcgggcccgc ttcggctggg
     5401 tctcccccgc cgtctaccgt cgcctgcgcg gtgaccgcct ggccccggcc aggatgtggg
     5461 gcgccgggcc ggtgcccgcg ccggccgccc ccgggaccgt cggccgcgcg cgccgcgaga
     5521 acgtcgtgct cgccccggga cccggcccgc gcgtctggcg gttgcgggcc gacatgaccg
     5581 acacgctgct cttcgaccac cccgtggacc acgttcctgg actcgtcctc gtcgaggccg
     5641 cgctccaggc cgcgcacgcg cacgcgcccg ggctcggcat cagcaccgtc gcctgcgact
     5701 acgagcggtt cgccgaactc gacacgccct gctggatcgt gagccgggcc gagcgcccgc
     5761 cccgccccga cgggcggacg gtgatcgagg tcgaaggaac gcagggcggg cgtccggtgt
     5821 tccgcgtcgc ggtggacggc acgctgccgg ccgcgggggc cgcggcgccg ccgcccgcca
     5881 cccggaccgg cgcgccggcg cccctcgcgg cacgcgacgt cgccgcgtgc gcgctgccct
     5941 gaaccgcgcc ggggccgcct ggaccgcgcg gccccgggca tcgcgtggcc cggggccgcg
     6001 ggggcgggcg ctacggctgt tcgacgacgc ggaagtgcag cacgtcggtg tactcgcggc
     6061 cgtggacgtc cgtcgcggtc acctcggctc ggtgccgtcc cgcgtcgagg tcggcgggca
     6121 gttcgaaccg ccacaggtgc atggtccggt cggcgacgct gccgccgtgc accagttgct
     6181 gggcgacggc gtgcggatcg gaccactcgg gaccgatcaa ctggtcctcg ccgcgcatcg
     6241 gctgggtgcg gacggcctcg cgggaacgac cgccgtcgat ccgcacctcg accgtcgaac
     6301 cggtcgagcc catccagaag ttggtggtca gccaggtctg cccggccagg tccgcgcgcg
     6361 tcaccacgtg cgggtcgccc agttcgggcg cgggcccctg ggggtcgtcg ttccacgcct
     6421 ggcgctcggc gtaccagtcg cggtaggtgg gactgttgat gccgagctgc gtctgcaccc
     6481 ggtcgctctc gccggtcacg gtgtaccgct cccggaacga gtcgcccctg atgtcgagcg
     6541 tgagcaggcc gggccggccg ccgtcgcgcc cgaccgccgc ggggtagccg tgctcggtca
     6601 gctcgcccga gtaccagtcg ccggagatcg cgcccgccgt gatgtgcggg aacggcagcc
     6661 cctcgacgcc gaagaggtcc tgccagccgc gcatgaggtc gccggtgcgc atgttctcga
     6721 tcgagtgggt gtgcccggcg acggagacgg cctcgcggcc ttcgagcagc gcgtagatgt
     6781 cgcggacctg gtcgacctgg tggatggggc tgccctcgtc ggcgaacgtc agcagcggga
     6841 tgtggccggc gatcacgacg agcttgtcct cgtcgaccgc ggccaggtcc cgttcgagcc
     6901 aggcgagctg gtgctcgtcg agccggccgt tgtagcgcgg gctgttctcc ggatcgtcgc
     6961 actgcgggcg caggccgtcg gcgttgtcga cgtcaggggt gcaggggtag cggacggtgt
     7021 tcagcgcgac gacgtgcacg tcaccgacgt cgtaggagta gtaggcgggc gcgagctgcg
     7081 cgcggaaggt gtcgaacgcg tgctcggcgg tggcggagtc gaagtcgagg tcgtggttgc
     7141 ccgggaggaa cctggccggg ccgttggtga ggctggtgag ttccttgacg tccgggtaga
     7201 gcgacaggtc gtccccgacg acatcgccga tgaacagcgt gccgcagccc tggtagtcgc
     7261 gacggccggc gaggtcgctg atcgcgcccc ggcgcgcgta ctcgacctcg gtgcggtcgt
     7321 aggtctgcaa gtcgcctgcg atgacgcagt gctgctcctg cgcccgggtc aactggctgc
     7381 gcacgagcgg gaagttgacc gcgtccggca ggggcccggt cggcgcgatg ccgccgtagc
     7441 gcagctcggg cgagccctcg ggcaggtggt tccagtggaa ctgggcgacg ttcgactcgt
     7501 ccaccggcac ctggtagccg gacggctggg tgatgaagac cgtcatgttg tcgtacacgg
     7561 gcagccggta gcggccgtgg cggtcggtcg tcacgacgtc gcgcccgttc gacacgacga
     7621 cgccgggcag gccgcgctcc ccgcggtcgt ggacgctgtc gcggtcccgg tcgacgaaga
     7681 cccggccggt caggtggtcg gggtcggcgg ggccctcggg ggtgcgcacg acctcgacct
     7741 ggccgcggta ggcgttctcg tcccaggacg cgggcgccgg gcccggcgtc gcggtggagg
     7801 cggtggtggg gatcgccacg agcccgcccg cgaccgccag ggtcgtgaag gcggtcaggg
     7861 cgatacggag gctgctgtgt tttcgcgcgg ggaaactcaa catgtggggt tctccggttg
     7921 tcgtgggggt gcggtaccgg cgcggtcggc cgaccgcggc gacgatcctt cggcacgtgc
     7981 ctgaacgcgg cacgctcaac ggaagaacag cagccgtacc ggcgccgccc cgcgcacgaa
     8041 cgcgtggcga acgtgtggtg tcgcgcgcgg ggtgacgccc cgtccgcccc gtccgccgcg
     8101 gccggtgcca cgcgccaccg ccgagggctt gcgaccggct accgcgggga gggcttgcga
     8161 ccggctaccg cggcgaggcc accagccgta tcgccagccc cgcgaacacc gttccactga
     8221 agatgctgag cccgcgcgcg acacggcggc tgcggcgaag cagcatggcg agccgccccg
     8281 agagcaggcc gaccgttccg tcgacgcaca gtccgatgac cacgatcgtg atgcccaacg
     8341 tcagcagctg cgccggcacc tgcccccggc ccggatcgac gaactgcggc aggaaggcga
     8401 cgttgaagag gatcaccttc gggttgagca ggttgatgac ggccccctgc cagaaggcgc
     8461 gccggtaccc gggcccggtg ttctcgtccc cgctcccgag gggcccgcgg tcgcggaacg
     8521 ccttgaccgc caggtacagc aggtaggccg cgccggccca gcgcagcacg tggtagagcg
     8581 ccggcagggc cgtgaacagg gcggagagcc ccagggtcgc ggccaccgcg tgcacgcaca
     8641 tggcgccggc cacgccgagc gcggccatca cgcccgccgc ggggccgccc cgcccgccca
     8701 tcgccacgat gaacatcatg tcggggcccg gcgtgacgca gagcgcgagg gcggccacga
     8761 gaaaggccgc gtacaacgat gaatccacca tgcggggcat cctcgccgcc cggaacccgc
     8821 gcggcgaccg gattccgcta cgtgggacgg gcggcgcggc gaaccctccc gggcggtgcg
     8881 ccggggccgt cgccatggcg gcccatatcg gccgcccgcg tgtgtccgac tccgtggccc
     8941 tcccggtcgc ggcccccggc cggtgagccg cccccctgcc gcgcgagcgc gtgaggccat
     9001 gcgtgccgga gatcctgtcc cgacggtcga agcgtccggc cacgaccggc gaagcgggtt
     9061 caagcgggta ataccgtcga agagttggtg gaaccagcga ggagcgatat gggcccgtcc
     9121 cgccgtgggg tgctgcgtac cggcctctac tccgtcgcac tgaccgtgcc aggacggccg
     9181 gagatcgtcg accgcgtgca ggcgttccgc ggtggacgcc tgtcgaggat cggcatgggc
     9241 gaggtcgcgg tggtcaccgc catgacccga aggattcagg aactcgacga tcagttcggc
     9301 acccgccacg cgcgccccct ggcggccaac ttcctggtga acaccgccgt gccctacctg
     9361 cgagcggacg ccgacgaaaa cgtgcgcgcc gcgctgctct ccgccacggc ccgcctgtgc
     9421 cacctgaccg gctacatggc cgtcgacgaa gggttgcacg gactcgccca gcgctactac
     9481 gtgaaggcgc tggagttcgc cgacgcggcg gacgaccgct tcgcctacag cggaaccctg
     9541 cgcgggatga gcgtgcaggc gaccgatctc gggcatgccg ccacggccct gcggctcgcc
     9601 gacgcggcag cggaaggcgc ccacggcgcc ccgcagccca ggcgggcgtt cttcgcgggg
     9661 cagcaggcgc acgccgcgca gacgggcgac cggcagacgg cgctgaggca cctggccacg
     9721 gccgagcgcg ccatgagccg cgccgacctg gggggcgcgg cgttcgcgtc ctacgacccg
     9781 gcggccctga acgaccacgt cagccaggtg aggtgggaac tcggtgacat cgcgggtgcg
     9841 gtggcgtcgt tgcgcgcgtc gaacagggga ctgcatgtcg ggtaccagcg caccacggtc
     9901 cggcgccggt tcatgctggc ggaacggtac ctgcggctgg ggcatctgga cgtcgcctgc
     9961 gccacctggg cacgcgcgct ggacgattac ccggggatcg actccgggcg cgtggacgaa
    10021 cgggtagccg ccatgaaggc gttgctccgg ccgcaccggg gcaacggtgc cgcccgtgcc
    10081 gtcctcgcac gggccgacac gcccgccagg gcacgcgggg cggccggcgt tccctgacct
    10141 gcgtcgcggg cccttcgggt cggcgttccg ccccgaaggg ttcgcccggg gcggaacggc
    10201 gggagccgcc tcgcgcgtgc gggtagcgac ggttcgggga cgacggctac gagaggtggg
    10261 gcacgatgcc ggaagcggcc tacgacgaga tcgccgactg gtacgagacg gagttcaccg
    10321 ccgggcagcg gtacggcgcc gcgcacgcgg acccgctcgg tctcgacgcc ttgatacgcg
    10381 acctcctcgg cgcgggctcg gggccgtgcc tggagatcgg ctgcggtacc ggagtccacg
    10441 ccgggcgggt gcgcgacctg ggctggacgc ccgttggcgt cgatctgtcc ggcggaatgc
    10501 tgcgccacgc gcgcggccgg ctgcccgtcg cgcgcgcgga cgcggcgcgg ctgccggtgc
    10561 gggacgcctc cgtgtccgcg gtgctctcgg tgatggtgca caccgacatg cccgactact
    10621 cggccgtggt gcgggaggcg gcgcgcgtcc tgcggccggg gggcgccctg acgcacatcg
    10681 gcgtgcaccc gtgcttctgc ggcgcgttcg ccgaccggcg cgacgcggag gccgttgtga
    10741 tcaggcccgg ctaccgcgag agccactgga gccgcgagtc gtggacggac cagggcgtgc
    10801 gcgacaaggt cggcgcctcg cacctgccgc tgcccgccct gctcggcgcc ttcaccgcgg
    10861 ccggtctggt cctcgaccgg ttcgcggagg gtggcggccc gacgcccgtg gtgttcgggc
    10921 tgcgcgcggt ccggccggcc gacggggcgg tagcgcgccc ctgacgcggc ccccgaccgc
    10981 cgtcgcggag tagcccggcc gtgcggccgg aatgcggcgc tccggcggcg gttttcggcc
    11041 aacgcggcgg attcggccgc cggttcgacg tccgggcgcc gtttcgccgc ggtgaacgat
    11101 cggcccttca ccgggtgggt acgaaacgga cgccccggcg cctccgccca cccacccgcc
    11161 cccgggcgcc acacgcgccc cgcgcgccac cggcgcagcg aacgaagcgg ggagagcacg
    11221 gcaacgcgcg ggccgcgcac cgctgcgggg tcacggcaaa cggcccgggg cgccggcccg
    11281 ccgccgcgca cctggcgtca tcccccgacg ggcaggccgt tcgcaaattc tccctcgctt
    11341 ccgcacacac ctcgcggcgg cccggtggcg gctctacgcg cgttcttgtg gcacttcccg
    11401 cgccctccta tcgtccgtgc ccccggcatc agggagagcg agggaggtgg catgacccgc
    11461 gcacacagcg agaacacgaa ttcctcacgt gatttccggc tgctgtggac cgcatccgcc
    11521 gccgactccc tcggcaccca gacctccggt gtcgtcctgc cgctgctgct gctcgccgcg
    11581 gggcattccg cgaccgtcgc cggcgccgtc gtctcggtgt cgctcctggc cgggctgctc
    11641 gccggcccct tcgccgcggt gctggccgat cgcggcggac ggcgcaccgt gatggcgtgg
    11701 tccgcgctga cggccggggc cgccatggcc gtggtcgcgc tcctcgccgc ctccgcgcgc
    11761 ccgccgctcg gggcactgct cgcggcggtc acggccgaac gggtcgccac ctccgcctat
    11821 gccgccgccg cccagggctg cgtggcggcc ctggtgccgc ccgccgccta cccgcgcgcg
    11881 gtgtcccggc tccaggccgg cgagcagggg gcgctggtgg cggggcccgt gctcggcgga
    11941 ctgctgttcc aggcggcgcg ctggctgccg ttcctcgtcg acgccctgac ctacctggtc
    12001 gccgtcctgt gcgtgcggtc gatacgtgcc gacctctcgc ccggcgcggc gagggaaccg
    12061 gggcgccgcg gcgtcggcgc ggtgttcgcc gacctgcgcg acgggctgcg cttcgtccgc
    12121 ggggaatcgt tcctgcgcgg cgtgctgtgg tggatgacgg gcgtcaacgg ggtgctcgcc
    12181 gctctctact acggtgccgt gttcgcgctg gagcggcacg gcgccggaac cgcggccatc
    12241 ggcacggtgc tcgccgtctc cggcgcggcg ggcgtggtcg gcgcgctgct cgccccgcgg
    12301 ctcgccgcgc ggattccggc cgcgcggctc gcggtgctgg tgtcctgggc cgtcgttctc
    12361 gtggccctgg gcctgacggc cgccacccgg ccctggtcct acggcctgct gttcgcggtc
    12421 gtctcgctgc tcgtcccgac cctcgcggtg ctgctggccg cgcaggccat cgccgttacc
    12481 ccggccgcgt tccagtcgcg ggtcggcacg gtgctgaaca ccgtctcggg cgtcgccgcg
    12541 acggccgctc ccctggcggc cggcgcgctg gtggcgctgg ccgggaccac gggcctcgcc
    12601 ctcgcgggcg cgggcacgat ggccgtggtc gcggtgtacg cctcccgcgt ggtggcgccg
    12661 ggactgcgcg cggcggcggc ccgtccgtcc ggcgcggcgg ccgcccccgc gggacgggag
    12721 gccacgccgt gacggccggc gcggcagggc ccgccccgga gcggcgcgcg tacgccgtgt
    12781 cgcggcccgt gctgcccgcc gtctgccggg acgcgcccga gctgatggcg ttcgccgggg
    12841 acgcggacgg ccggtgcgag atcttcgcgt ggcacgcggg caccggcgag cgccggcagg
    12901 tcaccgaccg gcccgagggc accgtgcggt gcgcgatcga tccggacggc gtgatctggt
    12961 ggttcgccga gcgggccgac ggcaccggga cgtggctgac ccaggacttc gccgggggcg
    13021 cggacgtccc ggcgttcggc ggggaaccgg ctcggggccg acccgcgggg ctcgcgctgc
    13081 caggcggtac ggccgccgcc ggtctcctcg acgcggaccg gctcaccgtg cgcgtcggcc
    13141 ggcgcggtga actcccgcgg cacacattgc gtttcgacgg ccaggcccgg ctggccggct
    13201 tcgccccggc cgccgggctc ctcgcggtgg cccgcgcgcc aggccacgaa cgggcggtca
    13261 ccctgcacac ggtggacggc ggcacggtcg cggtgctgcc gggacgcggc ggccggatct
    13321 ggccgctcgg tttcgcgccg gaacgcggcg gcgggccggg ggtagcggca ggcgaaccag
    13381 cttccggcgg cacggagttg ctgctggtgc gcgaggacga ggacggctac cggctggcca
    13441 cctggacccc ggagggcggg ctgctggcgc acgcgtggtg cgcgttcgac acggagatca
    13501 ccgcccagtg ggtgccaggc gggcgcgagg tgctggtgcg ccaggagcgg cacgggcgca
    13561 gcctgctggc cctgtgcgac ctcaccgcgc gcacccgccg cccggttccc gtgcccgagg
    13621 ggacggtgct cgacgccgcg gccgacgcgg ggggcgcggt gcactgcctg tggaccgaca
    13681 cccgcacgcc cgcgcgggtg ctcaccgcgg gaacggccgc gcgcctgctc cccccgccgc
    13741 ccccggaacc gccgccgctg gaggccgagg tgagcgacct gtggaccccg ggcgaggacg
    13801 ggcccgtgca cacgctgctc gcgatgccgc ccggccgcac cggccctggg cccgtggtgt
    13861 tcctcgtcca cgggggcccg gcgcggcacg acaaggacgc ctacgacccg gccgtgcact
    13921 cgctcgtggc ctccgggctc gcggtggccc gcgtcaacta ccgcggctcc accggctacg
    13981 gcccccgctg gcgcgccgcg tggggccggg gcgtcgggct gacgcaggtc gaggacctgg
    14041 ccgccgtccg cgccgacctg gtggaccggg gcatcgccga tcccggcgcg accggcctgt
    14101 ggggcacgtc ctggggcggc tacctggtgc tcctcgccct ggggtgcagg cccggcctgt
    14161 ggcgcgcggg cgtcgcggtc aagccggtgg ccgactacgc cgccgcgtgg gcgctcggca
    14221 cgcccgaact gcgcgcgctc gacaccgcgt tgttcggcgg cacgcccgac gaggtgcccg
    14281 gccgttacgc ccgctcctcg cccgtgacgt acgtggccgg ggtccgggcg cccctgctgg
    14341 tgatcgccgc gacgcgggac gccaagtgcc cgcccgagca ggtgcgcggc tacctcgcgg
    14401 cgctgcgcgc ggccggcggc acgtgccgcg agctgtggct ggactccggg cacgacggcc
    14461 acgacggtgc cgggcacgtg cgcgtgctgc ggcacagcct ccacttcctg gcccgcgagt
    14521 tgcgcgcctc gcgggccggg gttcccgccc cacgagacga cggagggagg tgatccccat
    14581 ggagaaggac gtgattcaga acgacccgct ggagcacgag gccgaaggcc gctcgcctgc
    14641 cgtcaccgtg accatcacgg tgccgctgat gacgccggag gacgaggacc tcgacgtctg
    14701 accagcccgc ggccggcccg gcccccgggc cggccgcccc ttacggattc caggagggag
    14761 cagccgtgcg ggtgcttctg atcaacatgc cgtggtcccc gatcgacctg ccgtccctgg
    14821 cccttggcat cctcacgcgc agcgtgaacg agaaggtgcc cggcgcacgg gccgaggtgc
    14881 tgcacggcaa tctcgactac ttcgactggt tgacggccag gcccggcttc gccgacttca
    14941 ccgcggacga ctacgcctac tacgccctgt cctcctactt cctcggctgc ggcgactggg
    15001 tgttctcctc cgcgctctac gacgaccccg agtggcgggt caccgagttc agcgaggcca
    15061 tgcgccggcc cgtcggtgcg cggcggctgg cccaggccgt cgaactgcac cggggcgcgc
    15121 ccgagttcgt gcgcgagttg gcgatgcgcg tggtcgcgca gaagccggac gtggtcgggt
    15181 tcacctcgac gttccagcag aacaccgccg cgctcgccgc cgcccgcatg atcaaggagc
    15241 tggcgcccgg gacggtcacc gtcatgggcg gcgcgaactg cgacagcgcg cagggcgagg
    15301 ccacgcaccg caacttcccg ttcgtcgact acgtggtgcg cggcgagggc gaagtggcgt
    15361 tccccgccct gctgaacgcg ctgcgcgagg gcaccggcct cgccgggatt cccggcctgt
    15421 gctggcgcga cggcgatgcc tcccgggcca acccgatggc gacggcgccc ctgccgccgg
    15481 ccgcgatcgt ctcgcccgac taccgcggct acctggaccg gctggccgcc tcggccgccc
    15541 ggcacatgat cgagccgaag ctggtgatcg agggcgcgcg cggctgctgg tggggcgaga
    15601 agcaccactg cacgttctgc ggcctcaacg gctcgttcat gcagttccgc agcaagtcgc
    15661 cggacgcgtt cttcgacgag atcgtcggca tggcccgcga gcaccgcgtt ctggacatgt
    15721 acatcgtcga caacatcctc gacatgggct acgtgaccac cctgctgccg cggctcatcg
    15781 agaccggcta cgacctgcgg atgcacgtgg agatcaaggc gaacatgcgc cgcgagcagc
    15841 tgaagacgct cgcggacgcg ggtctggtgt tcgtgcagcc gggcatcgaa agcctcaaca
    15901 cccgtgtgct cggcctgatg gacaagggtg tcagcggctg ccagaacgtg cggatgttgc
    15961 gcgacggggc gagcacgggc ctgtcggtgt cgtggaacta cctctacggc ttccccgagg
    16021 aacgcgagtc cgactacgag ccggtgatcg cccagatgcc cgcgctcgaa cacctcaacc
    16081 cgccgaccgg gctgtccgcg cgcatcgcga tcgaacggtt cagcccctac ttcaaccgcc
    16141 cggagctggg cttcagcgag ctgcgcgccg ccaagccgta ctggctgacc tacgacctgc
    16201 cggagcagga gctgtacgac ctcgcgtaca tcttcgacgc gccgcagcgc ggcatcggcg
    16261 cggcgaccgc gaagcggctg aacgaggcgt tgagcgcatg gatggacgcc aacgccacga
    16321 gccgcctggt ggggcacgac ctcggggaac gcctggtcct gctgaaccgc cgccgcgcct
    16381 tcccctggac gaccctggtc gtcgacgacc cgctggagct cgccgccttc cggctgctcg
    16441 aacagccgcg gtcgccgcgg acgctggtcc gcaagctcgg tgagctgttc cccggcgcgg
    16501 acgccgaggc gctggtgccg ccgctccttg agcgctggtc ggacctcggg ctcctgttca
    16561 ccgacgccgg ccagtacgtg cacgtggtgc ccgcccccgt caacgacgag atgctgcgcc
    16621 tgggcttcat gcgcggcgtg gtggcagacg cggccgcccc gccgccggag gccgccgccc
    16681 gggacaccgg ccggacgccc gccgcgcttc ctgcctgacc ttcgaggagt gatgaccgtg
    16741 agcacttcgc ccccggccgt cagggcctgg cgcgactacg acgcccgcgc gctggagacg
    16801 cccgggatgt tcctgggcga ggtaccgctc tccgggccga cggacgcgct cgtcgaccgg
    16861 ctgtgggacc tgggcgcccg ccgggtcgag ctgccggggc gcgtggatct cgccgatccg
    16921 ggcgacccgg agggcacggt gcgtgccctc gggctggtca gggacctgac cgcgcaggcc
    16981 gtgtacacgc agtggcggct gcggctgccc gcctcggccc ccgactgggt gccgttctgc
    17041 cacctccagc cgcccgccgt cctggagggc gtgccggacg ccggggccgt gctcgcccgg
    17101 tggcgcgaga cgcactacct gggcaagtgc cagtggcggc gagggcccgg cttcttccag
    17161 ctgcgcgacc gcaggtgggg cgacctgcga cggttcaccc tgacggacga cgcgtacctc
    17221 gcggcagtcg aaacgctcgt gcccggcgcg cgggcggacg acgtgccgac gccggtgctg
    17281 gcggcgttcg aagccgagaa gctggcctgg cgcgtcggcg accgggtcgc ctggctgccc
    17341 tacgccacgc gccgctgggc gcagtccgcc atgctcatct gagggtggcg gcggtggcgt
    17401 gagggccggt ggaccggccg ggtccgacgg cgacgggggg ccgccggacc cggccggaca
    17461 ccgcggggcg tgcggccgtc cgccgggtca gatcacgcgg aacaggtcgg cggcggcgtg
    17521 cacgtcggtc aggtcctcga tggagcgcac gttgtcgcac aggacgtcga ggaccgaccc
    17581 cgccgcgacg gcgccgggcg cgccgatgga cacgccgaag acccggaacg ccagccggcg
    17641 ctcggcctcc cgccagtcgc gcagccactc ctgggtgacg tcgcactcgt cgtcggtgat
    17701 catcacgatg tcgccgcgcg tgcgggcggc ggcatcgaac tcgtccgcca gcaggtcgcg
    17761 ggccgccgtc agcggggtct ggtagctggt ccccccgccg aggaaggtct ccgcgaagtc
    17821 gaggacctgg tcgatgccgg cgggcgcgcc ggccgggaaa cggaagatcc gcgtccggtc
    17881 ggcggaggag aacaggatgc cgacgaagtc acgcccggcc cgccgggcct ggtcgagcag
    17941 cgccagcgcg cacgccttcg cccacgcctc ccgggtcaca ccgccgggcc cggccgcgta
    18001 catggagtgc gaggtgtcca cgcaggcgat gacggcgccc cggccggcgg gccgttccgc
    18061 cctggtgtcg tagagcatca gctccccggc ggcgtagcgc gcggcgaaca ccgcgcgcgt
    18121 cgcgggcagt ccgaggtggg ccagctcgga agggatgacg cgggagaggt cgtcgccgag
    18181 cgtgacgccg accagttcac ccgcggtgct ctccaccgcg cgggcgtgct cgccggcggc
    18241 catctgccgg aagcggccga tgagttcggc ccaccgcgcg aaccggcccg tgcccagccg
    18301 ctcggcgagc cgggcccgcc ggtcgaacgg catccgttcg aggtcgccgg ggccgagccc
    18361 ccacgcccgc atcagcgcgg cctcgtggcg cgcggcccgg gcggcccggc ccgccgcgtt
    18421 ccgcgcggcg gcgtcaaggc cgggggccgc ggctgcgagg gcgcgcccgg cggcctcggc
    18481 ggcctgtcgg gcgacccggt cggcgggggc gtcggccgtg ggcccggcgg cctcggcggc
    18541 ccgctcggcc gctgccgccc ggtcggcctg ctcctgggcg gcacgggaac gctccagcat
    18601 gccgcgcagc gcggcggcct gggcgagcac ggccatggcg gcggcgtacg ggtcgcccgc
    18661 cgtctcccgg tgcaggtccg cgaagtgcgg cgcggccacg agcgagccga cgatccggtg
    18721 gttgaccagc cgggcggggg ccatctcccg gcggtcgcgc agccgcgggc gggtctggta
    18781 ggcggcgagg aacacgtcgg ccatcagatc ggccgcccct gcgtggcgcg cgcccagttc
    18841 cgcggcgagt gcgcgcagcg cggccgactg ctcgcacgtg tcgcgccagg tgatccggtc
    18901 gaaccggtcc gcgaccacgg ccgcggtgtg ccgttcgggg gctgcgccgg gcggcccggc
    18961 cgggcccggc ggcacgcccg ggccgttcgg tgtcccgctc atgtccggct cccgccgcct
    19021 cagagccgct cctgcaccat gctcgcgtcc acgccgagcg cttcggtgag cacgcgggcc
    19081 cggacggccc gctggcggcc ggtgatccgg tcgatggcgg tggtggaacg gccggcgctc
    19141 gccgcctcgg cgcgcagttc ggcaagccgc ctgcccgcgg tggccagctt gttgtgcgcc
    19201 ttcttgatga cccactcgct cagcgcctcg cgggactgcc cggccatcgc gtcgagctgg
    19261 gcctccaact cctcgatggc gtcggccaga tcgagggcct ccccggcgtc ggggttcacc
    19321 acgagcagca cctcgcgctc gacggccggc cgttcggcgg gcgcgttcca cagcacgtgc
    19381 gtcagcacgg acaggtcggt cacggcgacg gcctggcggc cgtcgaggtg ggcggacgcc
    19441 tggagcagac ccaccgcctg ccgccagcgg cggtcggagg cgacgatttc cctgcggcgc
    19501 agagcggcgc gcagggtgca caccgcgtcc acgaccgggt cgggaacgtc aacggcggga
    19561 acggcttccg tcacggcgtg tcgcagcgcg gccagttcca ccgtggtccg cctccgtgcc
    19621 accgggcggt cgaccgcgga gcgcaccagt gccgcgaagt tcgatgggtc cgcgagatag
    19681 ccgacctcga tccgcaccag caggcggtcg tagatcgcgg ccgtgtcctc ggcggccggc
    19741 agctcgttgc tcgccgtgat ggcgccgatc aaggggcagc ggatcggctc gccgccgctc
    19801 tccgggtggt agatccgctc gttgaggaag ccgagagtct cgttcagcgc cgcagtcgag
    19861 cacttgaaga tctcgtcgat gaacgcgacg tgcgccgtcg tggcgcggcc ctcgtagatc
    19921 tggcggtact cgccccgggc cagcgcggcg acgtcgatgg gcccgaacat gcgggtcggc
    19981 gcggtgaact tggacaggag tatctcccag taggccgcac cgtcgatccg gccggtgagt
    20041 tccctggcca gctccgactt ggcggtgccc ggcgggccga gcagcagcga gtgctgccct
    20101 gcgagcagcg tcaccacgag agtccgcacc acgtcggcac gctcaaggaa gcgttccgac
    20161 aactcgtcgc agatcgaccg cagtcgcgcc gccgtgtccc gcgtgccctg tgcgtccatg
    20221 tgcccctccc tgcccgcccg cgcccgcggt ggcccggcgt gccgccgccc cggcgtcacg
    20281 tgcgcgccgg ggcgcggacg accggcgggg cggcggtcac gccgttgtcc ggcggaaacg
    20341 gtcccgtgcc gagacgataa cgcgcggggc tccgggtcct tccgggccac cggccggtgc
    20401 cgcgcgccgg tgcccgccgg ggtccgggcc cgtggcgcca ccgcccggcc cgcgggcttc
    20461 actccgcggc cttcggcccg atccgcttct cgaaccagtg gtgggcgtag cgctcgtcgt
    20521 tgaacgcggg cacctcgtgg aagccgcagg cgcggtacag ggcgacggcc gcgtccaggg
    20581 ccctgttcgt gtcgaggcgc agcaggtcgt gaccgtggcg gacggccgcc gcctcaagct
    20641 cggcgaggag gcggcgcgcc aggccgaggc cccggctgcc cggcgcgacc cacatccgtt
    20701 tgatctcggc cggagccccg gccggcagcc tgagaccggc gcagcccacg ggttccccgt
    20761 tcagcctggc gacgaggaac aggccgcgcg gcggcttgag tcctcccgcg tcgggcagca
    20821 ggctcagggc cgggtcgaag ccggtgtcga ggcgttccgc cagttcggcg gcgtaggcac
    20881 gcaggcagtg cgcggcgtcg gggtgtccgg ggtcgacggc gtcgatgcgg acggtcgcgg
    20941 cggtcaggag ccgttcgacc tcggccatgg cggcgaccag ccggtcgcgc gcggccgggt
    21001 tgagcggcgc gagcagggcg ccggccagtt cgtcgctgcg gtcgtcgagg acgcggcgct
    21061 cggcccggcc cgcggcggtg agccgggcgg tgcgcacgcg gcggtcgcgt gcgtgcggct
    21121 cgaccgtcac caggccgtcg gcttgcaggg agcgcaggag ccggctgagg tatcccgagt
    21181 cgaggccgag gctttcgcgc aggcgccgca cgtcctgccc gtcctccccg atctcccaca
    21241 gcagtctggc ctcgcccacg ggccggtccc tgccgaggta gtggtcgtgc aggacgccga
    21301 ggcgtgccgt gacggcgcgg ttgaaccgcc ggacccgatc gatctgcgcc gcatccattc
    21361 tctgaccata gtcagacgtt ctgccgcggg ccagggcgcc ggcggcaccc aggtggcggt
    21421 gaccggaaaa cgacgggaag ggcgcggtgg aggcggagcc gggtcggacg ccgcgcgggc
    21481 acaggatatc ttgatgtcga gcaatgttgc atacgtggag cggagcaccc ggtgactgac
    21541 tcgaccatca tctacaccca cactgatgag gccccggccc tggcgacgta ctcgttcctg
    21601 cccgtggtgg aggcgtacgc cgccaccgcg ggagtgcggg tcgaacgtcg cgacatctcc
    21661 ctcgccggcc gcatcatcgc cgtcttcccc gaatacctgg agccggagca gcgcatcg
//
