LOCUS       NZ_CP019779            21098 bp    DNA     linear   CON 14-MAR-2024
DEFINITION  Streptomyces sp. MOE7 chromosome, complete genome.
ACCESSION   NZ_CP019779
VERSION     NZ_CP019779.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. MOE7
  ORGANISM  Streptomyces sp. MOE7
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8399509)
  AUTHORS   Elnahas,M.O., De Leon,K.B., Amin,M.A., Hussein,M.M.D., Ali,A.E. and
            Wall,J.D.
  TITLE     Complete Genome Sequencing of Streptomyces sp. Strain MOE7, Which
            Produces an Extracellular Polysaccharide with Antioxidant and
            Antitumor Activities
  JOURNAL   Genome Announc 5 (22), e00442-17 (2017)
   PUBMED   28572320
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8399509)
  AUTHORS   Elnahas,M.O., De Leon,K.B., Amin,M.A., Hussein,M.M.D., Ali,A.E. and
            Wall,J.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-FEB-2017) Biochemistry, University of Missouri
            Columbia, 117 Schweitzer Hall, Columbia, MO 65211, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera Assembler v. 8.1
            Genome Coverage                   :: 180.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002090335.1-RS_2024_03_14
            Annotation Date                   :: 03/14/2024 02:19:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,435
            CDSs (total)                      :: 7,344
            Genes (coding)                    :: 7,005
            CDSs (with protein)               :: 7,005
            Genes (RNA)                       :: 91
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 339
            CDSs (without protein)            :: 339
            Pseudo Genes (ambiguous residues) :: 0 of 339
            Pseudo Genes (frameshifted)       :: 230 of 339
            Pseudo Genes (incomplete)         :: 155 of 339
            Pseudo Genes (internal stop)      :: 7 of 339
            Pseudo Genes (multiple problems)  :: 47 of 339
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:50:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7499990
            Orig. end                         :: 7521088
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP019779.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Judy D. Wall 117 Schweitzer
            Hall Columbia, MO USA 65202.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21098
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="24"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21098
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21098
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11098](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11098)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            707..1213
                     /locus_tag="STRMOE7_RS32890"
                     /old_locus_tag="STRMOE7_32885"
     CDS             707..1213
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019544546.1"
                     /locus_tag="STRMOE7_RS32890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_32885"
                     /product="Pycsar system effector family protein"
                     /protein_id="WP_084775293.1"
                     /transl_table=11
                     /translation="MSSGGVHIPTVGARLLMELRSETARADSKASLLLGAISMTVSLLG
                     GLLAARGWSLSGLSVPGSVLLWVAVTALAGALGCLLLAVLPRYGTSRWSPGRPLTYFDD
                     IRRAAEGGRLAEALAVTEAQQADGVLEALAQNSRIVGAKHRWIRAGLAAYCAGVVLLPI
                     ARLLG"
     misc_feature    869..871
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            1283..2476
                     /locus_tag="STRMOE7_RS32895"
                     /old_locus_tag="STRMOE7_32890"
     CDS             1283..2476
                     /EC_number="3.4.24.-"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090912.1"
                     /locus_tag="STRMOE7_RS32895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_32890"
                     /product="M48 family metalloprotease"
                     /protein_id="WP_084775294.1"
                     /transl_table=11
                     /translation="MTTPFDSAHPGRISLPEASAYPAAVPFPSPRRADETIPPPPSYPG
                     SATPAEAAHPAEEPEQQPFSENRAPQEGLGRRGRVHLARRQRGIDATAVGQLLLRLPSF
                     LASLVIVATLSYLLFPGMGWLGVLLWLGSGAMAFHRPTERALARHLLNLRHPTPEELNR
                     LEPLWREVAARTGVEGRAYELWIEDSDHLNALAAAGHIVGVTRFSLERLSDGQLAAVLA
                     HELGHHVRGHAWSLILGQWYAVPGWFAWAAVRRLIRLVTVVGRGRMSFWAAVLLLAVGA
                     IVLAVAWEYWFLTLTLVAAPYLLAAVTRRTELRADHHAVVAGFGPMLAEVLHMMQAAER
                     EGGHATVSALSGCGKTVAIDPRTAARGGRRSFLDKLLSSHPDCYTRLHHLAPYLERR"
     gene            2769..4256
                     /locus_tag="STRMOE7_RS32900"
                     /old_locus_tag="STRMOE7_32895"
     CDS             2769..4256
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037531.4"
                     /locus_tag="STRMOE7_RS32900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_32895"
                     /product="HEPN domain-containing protein"
                     /protein_id="WP_084776464.1"
                     /transl_table=11
                     /translation="MMGSDPLNLDAAGEWAGLWWLPEEPGYRVPGVLRYEPESGLTLSL
                     IGAFEDRVTTTPAPGVLMVHEGRRTWSVIHGAADQREISLFGCFAQGGRRTFGARVKTP
                     DKQTVVATTALIGAHVGGEDEAAFSTTEVSVEDLGHWAASSVFEGFLGAPGGRPDGSGT
                     ISVKPVEVQSVEVDGTEFVLAHRHTLPFFDQRRGGTVGRMSDTAYLQITRREAYSLSDA
                     MGYARLIQDLIALATHRAAGMIWVRLKLASDDTVSEPGGLRPARNVDALYSPSVVGKHD
                     AKAAAHHRVFFTCEALPFEEIIPRWCDMHERLQSATNMVLGLRYAPARYVENNLLTAVG
                     AAEVLHRGFDIDEPPIPSADFKPMREAMLAQVPEKHRDRIRGFLRNDPTLRDRLYALAA
                     RPDQEALSTLVPDVDRWARRTTRARNDLAHEGRTPNHELEELIAIVEVTTAVVILNLLN
                     ELGLPAERQREVVRDHPQLRATARSARDWLSGSEADS"
     gene            complement(4329..5408)
                     /locus_tag="STRMOE7_RS32905"
                     /old_locus_tag="STRMOE7_32900"
     CDS             complement(4329..5408)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014181092.1"
                     /locus_tag="STRMOE7_RS32905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_32900"
                     /product="hypothetical protein"
                     /protein_id="WP_084775295.1"
                     /transl_table=11
                     /translation="MHHPDPQHAARLATYGTVATRLSLLSDRRLGEVVAAAAPLGSGVG
                     GRSAELDIDGTRVFVKRVPLTDIELRPEHARSTANLFGLPLFYQYGVGSAGFGAWRELA
                     VHVMTTNWVLGNAYEGFPLMYHWRVLPDSPPEGFADTFGGIDGTVAHWEGSAAVRERLE
                     AIGRSSSSLVLFLEHVPQTLGDWLHDYRTAAPEGGNGSPYLWVEEALARGADFMSSHGL
                     VHFDAHFANVLTDGRLLYFADFGLALSSGFKLSGAEAEFFASHLAYDRCHTMRHLLHHH
                     LPEGLFGCLGHEVFLREWIAGRRPDGVPRAIAAIIDRHARTTVVIGEFARRLLTESKRT
                     PFPAAEIERARGTAVAARH"
     gene            5888..7099
                     /locus_tag="STRMOE7_RS32910"
                     /old_locus_tag="STRMOE7_32905"
     CDS             5888..7099
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004954296.1"
                     /locus_tag="STRMOE7_RS32910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_32905"
                     /product="ATP-binding protein"
                     /protein_id="WP_237323822.1"
                     /transl_table=11
                     /translation="MRRNRQVAQLREESRGQSAALARQQEATARLADSLVPEMLTRLRL
                     DEASEEALNWLTARWSGSYSGLPSEFQQAHWAVLRTVMDAVAAEEGLRDSAQRALVNLA
                     RRMQAIVHQQARELREMEDRHGQDPAVFGDLLRIDHNTALTGRLADSIAVLGGARPGRQ
                     WNRPVPLYSVLRGAMSRIVGYERVELSTSTECAVVGPAVEPLIHALAELLDNATRYSPP
                     HTKVHLTAAEVQSGVVVEIEDGGVGMSEQARHLAERRLEQAQQGFDLGDLGETPRLGLA
                     VVGRLTQAFGLQVSLRTSAYGGVRVVLVVPQQLITSAAEASGVAHGIGTFSGPRAASQP
                     GQVVSRQTAKPPAARRVDEAPQVVERTANGLPQRRRRERVAEAQAPAAPPGLRRELNGR
                     RESG"
     gene            7173..7580
                     /locus_tag="STRMOE7_RS32915"
                     /old_locus_tag="STRMOE7_32910"
     CDS             7173..7580
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017944875.1"
                     /locus_tag="STRMOE7_RS32915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_32910"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_033265420.1"
                     /transl_table=11
                     /translation="MSQQAASLDWMLKDLAESVPQTRTVLVLSSDGLRMGHHGGTTESA
                     ERLAASCSGLQSLASAVGSELPHLAGKMQLVVIEMEGGFFYLMAAGPRAYLAVLADDGV
                     DAGLMGQRMRDLIARLGAHITSPPRSDGQAR"
     gene            7577..7930
                     /locus_tag="STRMOE7_RS32920"
                     /old_locus_tag="STRMOE7_32915"
     CDS             7577..7930
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018846603.1"
                     /locus_tag="STRMOE7_RS32920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_32915"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_084775296.1"
                     /transl_table=11
                     /translation="MSDSPQDGTEERPERLYVITSGRSSASNDLDLVTLIVARTVPTAG
                     MQPEHAAILSLCQAPLSVAEISAHTGLPASVVSVLISDLLDAQQVLTRPPVPPADLPDL
                     SLIEKVIHGLQKL"
     gene            7911..8525
                     /locus_tag="STRMOE7_RS32925"
                     /old_locus_tag="STRMOE7_32920"
     CDS             7911..8525
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008744113.1"
                     /locus_tag="STRMOE7_RS32925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_32920"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_084775297.1"
                     /transl_table=11
                     /translation="MAFKSSELAEPPSEERLPHTASAAVKVVIVGGFGVGKTTMVGSVS
                     EIRPLTTEETMTQAGVGIDDRAGVEHKTATTVAMDFGRISISDELVLYLFGTPGQQRFW
                     FLWNGLFEGALGAVVLVDTRRLEDSFDVMGRLEESGVPFVVAVNSFAGAPDHTLQELRS
                     ALDLPSDVPLMSCDARHRDSSRDVLISLMHYLHSLVATESS"
     gene            8522..9910
                     /locus_tag="STRMOE7_RS32930"
                     /old_locus_tag="STRMOE7_32925"
     CDS             8522..9910
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008744114.1"
                     /locus_tag="STRMOE7_RS32930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_32925"
                     /product="cytochrome P450"
                     /protein_id="WP_084775298.1"
                     /transl_table=11
                     /translation="MSTPSHLPPPGCPAHALGQDGPQRLYGPAAEHDPMALYEELRAKH
                     GAVAPVLVHDDQPAWLVLGHRENLEVARTPGRFSRDPRAWGAVQDGTVVPEKYPLAPMV
                     TWWPVINFNDGPVFERLRGAVLESLQRFDRRGMRRYVTRFAHQLIDAFASNGEADLVAE
                     FSSQLPMLVMTQLIGAPEEHGPRLVRAVPDMLEGTETALESDEYVTKMLYQLVESKKAS
                     RGYDLTSWLLDHPAELTDVEVLAHVRVVLVAAYATTANLIANTLRMVLTDPRFRANLSG
                     GRMTLPEALEQVLWDQTPINTVLGRWATADTVLGGQQIKRGDMLLLSLAAGNVDPAVRP
                     DLTAPVHGNRSHLAFSAGPHECPGQDIGRAIADTGIEVLLARLPDIELTVHDFELERRG
                     TLMSQHLVRLPVRFAPRSVVATAPRAEPEPLPPLAPLKEAVQAAAGRPRSSRWSWLSRL
                     FGRR"
     gene            complement(10001..11098)
                     /locus_tag="STRMOE7_RS32935"
                     /old_locus_tag="STRMOE7_32930"
     CDS             complement(10001..11098)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008744115.1"
                     /locus_tag="STRMOE7_RS32935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_32930"
                     /product="hypothetical protein"
                     /protein_id="WP_084775299.1"
                     /sec_met_domain="T1TS (E-value: 1.1e-63, bitscore: 214.9,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIAEHGHASRIGWQLPPFFCPFAPSRHPKAAEIEQRAIEWIDAFG
                     IYPDATERAWGLATHSADFSCRIIPDGSVDHVLTFTLWNYWANAVDDWQDSGPAATDTA
                     SITDHGARLARALEMPGCDLLPPGPLTSALDDLVQRTHDLLTPFQLRRFAEGARDWLLG
                     AGWRTAQAERGRMPGLTDYAGLGALANGTRFSLTWADSANGIDLPPNTLYAAPVQAVTD
                     AAGWIVAADNDLFSYNKDDDQEPWEQNLINVLAHERGCVPGEAVAEAVALRDRVMTLFL
                     RLRAQLARGADEQLQRYLDSLQNYIAGSIAWQNVAPRYASPRNRNAWPVEGASFDVVWS
                     DSPSDPSIEPPAVPSLNWWWQQLEQ"
     gene            complement(11101..11874)
                     /locus_tag="STRMOE7_RS32940"
                     /old_locus_tag="STRMOE7_32935"
     CDS             complement(11101..11874)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735520.1"
                     /locus_tag="STRMOE7_RS32940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_32935"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_237323823.1"
                     /transl_table=11
                     /translation="MGLFDPSVKLNTTVSQRVLKNRIVSSQEAILDHAARTWAVGQSFP
                     AHLLDVGCGLGGGSLYWAQEHGANVTGLTVANDHIPVIRELARQAGVSGRVAPRVGDIH
                     DLTHERRYDAAYAIESSGYMDRKRLFQVVARALRPGGWFGIQEHFICRPEWTDWIDDYY
                     KTRLGTLTEYIHAAEAAGFELEQDEDVTDGVSEFWLQSMAWNTAELTRLEQGGEQASWS
                     RERLQQSALAHGKLFRIWRDHAVETRLLHFRLGGN"
     gene            complement(12337..13077)
                     /locus_tag="STRMOE7_RS32945"
                     /old_locus_tag="STRMOE7_32940"
     CDS             complement(12337..13077)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559468.1"
                     /locus_tag="STRMOE7_RS32945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_32940"
                     /product="flavodoxin family protein"
                     /protein_id="WP_084775301.1"
                     /transl_table=11
                     /translation="MSAAQSPSTDLPPARYDDLRALVFNCTLKRSPERSNTQGLIDRSV
                     GIMEAQGVHVDVVRAVDHDIATGVWPDMTEHGWQTDAWPGLYEQVTAADILVLAGPIWL
                     GDNSSVTKRVIERLYACSSLLNESGQYAYYGRVGGCLITGNEDGVKHCAMNVLYSLQHL
                     GYTIPPQADAGWIGEAGPGPSYLDPGSGGPDNDFTNRNTAFMTWNLLHVARTLKDAGGI
                     PAYGNQRTAWDAGCRHDYENPEHR"
     gene            complement(13355..15370)
                     /locus_tag="STRMOE7_RS32950"
                     /old_locus_tag="STRMOE7_32945"
     CDS             complement(13355..15370)
                     /EC_number="3.4.24.3"
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088641.1"
                     /locus_tag="STRMOE7_RS32950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_32945"
                     /product="collagenase"
                     /protein_id="WP_084775302.1"
                     /transl_table=11
                     /translation="MRYRLPLPRSLTGGLAACVATAGLLAAPAQAAPAQAAPHAPAAVR
                     PATASPPVPHAVPPTGPATGTNERPALQGRPLGVARLRPLSAKNPPISSTAAARHKGGK
                     HHPTASCSPSDFGSRTGSELVTFVKAATTDCVNTLFSVTGKDAHDVFREDQMVTLANAF
                     QSGATTYPGDNSDHVWQLVLFLRAGYYVQSNHPDDVGTYGPTLAAATRSGLDAFFANAH
                     SQDVTSANGDVLGEVLILTDSADEQARYLNTYKQVLGGYNSSYDTIPSMLAAVNDVYTP
                     LWRGNWNPDYVSAVTADPSIIDTLNSFALDHLDLLGTGNSYLDSNAGMNVARYVEHPAL
                     QDRVRPLMKGLLDASKVTGPTAPLWVTVASQADAYDKANCSYYGVCDLPGRLTEAALPV
                     TRACDATHTVRAQSLTPAELDATCASILGQGPYFHDLVKDDGPIPGQYESTVQLVVFGS
                     RNDYRTYAGAIFGVDTDNGGITLVGDPAKPDNQPLSIMYQKDSDDGFPARIWNLNHEYT
                     HYLDARDDMKGDFGRQTSVPDIWWIEGLAEYVSYSYRHVTDTEAVTEAGKHTYALSTLF
                     QSTYDNSDVTRTYPWGYLAARYMVEKHPSDVATVLGHFRTGDYAGGYAVYSTDIGTRYD
                     ADFDAWLTSCAAGACAAGQGTKTAPPAQRTPAHPTA"
     misc_feature    complement(15460..15470)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 19.65"
                     /tool="antismash"
     gene            complement(15702..16661)
                     /locus_tag="STRMOE7_RS32955"
                     /old_locus_tag="STRMOE7_32950"
     CDS             complement(15702..16661)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445571.1"
                     /locus_tag="STRMOE7_RS32955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_32950"
                     /product="LysR substrate-binding domain-containing protein"
                     /protein_id="WP_084775303.1"
                     /transl_table=11
                     /translation="MELELRHLRVLCAIADAGSLGRAASDLGYSQPAMSTQLQRIEQYF
                     GHSLFERNSSGVELTPYGTEVLAQARDVLARAAAIGRRPAADGARTPRPLRLAATNTPV
                     LAGMLIRLRSRLPDLALTVSSVYPSSEIIELLEQGELDAAVAADYPGLELRHSAAVAHR
                     GIVTEPSFVALPAGHRLRHCREVALADLADDAWFLTPDDGAGWPGVFYAACRAAGFTPA
                     AVHEFLGDQQQLQNMIGEGIGVSIVQATLRPIPGVLVRPLIGTPLWCRYVLAWRRESLD
                     DEVGDALFASAAAAYRALIAQSPHFRTWAARTWSVARR"
     misc_feature    16869..16878
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.9"
                     /tool="antismash"
     gene            complement(17035..17928)
                     /locus_tag="STRMOE7_RS32960"
                     /old_locus_tag="STRMOE7_32955"
     CDS             complement(17035..17928)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018552898.1"
                     /locus_tag="STRMOE7_RS32960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_32955"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_084775304.1"
                     /transl_table=11
                     /translation="MTSSPRPPHAGGRPDPKDGTTALGGESAPARGYLLDNARAEAGER
                     FVWLAELFDGVTRGHFDRLGVRAGSRCWEVGAGGPGIPEALAAAVGPTGHVLATDIDPS
                     WLKAGDGYEVRQHDVAADPPPEPGTFDLVHARLVLVHVPDRARALATMAAALRPGGWLL
                     VEDADTALQPLACLDDSGPAQRRANRLRDAVRELLKRRGADLHYGRTLPRALREAGLVD
                     VAARGSFPVGGPACHRLEAATIRHVRGELLAAGLADDAEIDAHLAAIHAGELDLTLAPL
                     ISAWGRRPAEPPPALG"
     misc_feature    17882..17896
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 20.47"
                     /tool="antismash"
     gene            complement(18194..18946)
                     /locus_tag="STRMOE7_RS32965"
                     /old_locus_tag="STRMOE7_32960"
     CDS             complement(18194..18946)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015655945.1"
                     /locus_tag="STRMOE7_RS32965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_32960"
                     /product="CbtA family protein"
                     /protein_id="WP_084775305.1"
                     /transl_table=11
                     /translation="MNSATVRTLLVRGMLAGLAAGLLAFGLAYLIGEPGVNAGIAYEDA
                     HTHEHEMELVSRAVQSTGGLATAVLVFGTAVGGIAALAFCCALGRIGRFGARATAALIA
                     VSAFVTVYLVPFLKYPANPPGSNEPDTIGKRTALYFGMIALTVLVGVGAVIVGRRLAGR
                     LGNWNATLAATAGFLAVIAVAMAFLPAVNETPKDFPATVLWQFRLASLGIQALLWTAFG
                     VIFGFLAERALRPHAPHPGQAAELPTPA"
     gene            complement(18966..19187)
                     /locus_tag="STRMOE7_RS32970"
                     /old_locus_tag="STRMOE7_32965"
     CDS             complement(18966..19187)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020120135.1"
                     /locus_tag="STRMOE7_RS32970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_32965"
                     /product="CbtB-domain containing protein"
                     /protein_id="WP_051732555.1"
                     /transl_table=11
                     /translation="MAHTAAAPAPLSSPAVTKLPIRAILPWAAFFGLLMLVLLYFVGAE
                     QGATSLLSGAGVHEWVHDGRHLLGFPCH"
     regulatory      complement(19221..19384)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            19455..20009
                     /locus_tag="STRMOE7_RS32975"
                     /old_locus_tag="STRMOE7_32970"
     CDS             19455..20009
                     /EC_number="3.1.3.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1101: phosphoglycerate mutase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014045238.1"
                     /locus_tag="STRMOE7_RS32975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_32970"
                     /product="histidine phosphatase family protein"
                     /protein_id="WP_084775306.1"
                     /transl_table=11
                     /translation="MTIRLTLLTPAPGPALREARVDDDGPLDEPGRQQAHAIAGDLPPA
                     DRHLSGPSRRCRETAAALGVDPAVDPALRDLDLGTWRGRTLDELATTDPAALAAWTTDP
                     AAAPHGGESIDQLCRRVADWMDQLPDDTGRVLALADPSVARAAVVHALTAPRYAFWRID
                     LRPLTPVHLTGRADRWNLRLG"
ORIGIN
        1 tgtacccggt cagccgcggt ttcccactcg accggagcgc ggacgccgaa cgtgccgtgt
       61 accaagctct cgccagagca ggcgatttgg gggagcaagc gggtctgcgc acgtcgtacg
      121 ccgtgcggct caggctggac gacgcggcga tcggccacca gcgggagctc cgccggattc
      181 ggtacagcga cgaacagctt ggactgtcac acgacgtggc gatgagggag gaccggctca
      241 gggcggagcg gaatgtggag caggcccggc acgatcacga actggtcatg ctgcagggac
      301 gtcaggatga ggaggccagg gagctggaga aggagaaggt ccgctactac gagtactacc
      361 tccagcacgg cggcgtgtcg atgtgggccc tgcacctggc acagcacccg gaggattccc
      421 ggctggtcat ggagaaccta cagggggacc aactgcacct gatccggagc cagtcagagg
      481 tcgccctaca ggtgttgaag gaagggaatc cggaggacta ccagcgtgcg ggactgaaca
      541 agcaggccgt ggagatcctg gaggggctcc tcgcacgcca cgtgcccggt atcgcttctg
      601 ctcctcccac gccggactcc ctgtcctggg ccgattcccc aggcacgccg gtgcctttcc
      661 acaagcagcg gggcgggttc tccgccgaca gtaccgagga ggggcgatga gcagtggtgg
      721 tgtgcacatt ccgacggtgg gagcccgtct gctcatggag ctgcgctccg agacagcgcg
      781 tgccgacagc aaggcgtcgc tgcttctggg ggccataagc atgacggtga gcctgctcgg
      841 tggcctgctc gcggctcggg gatggtcatt atccgggctc tcagtccccg ggagcgtgct
      901 gttgtgggtg gccgtcaccg ctctggctgg cgcactggga tgcctgctcc tcgccgtcct
      961 accccggtac ggcaccagca ggtggtctcc ggggcgaccg ttgacgtact tcgacgacat
     1021 ccgccgtgcc gcggagggcg gcaggctcgc cgaggctctc gccgtcaccg aggcacaaca
     1081 ggccgacgga gtactggagg cgctcgccca gaacagccgc atcgtcggtg ccaaacaccg
     1141 gtggatccgc gccggtctgg cggcctattg cgcgggcgtg gtgcttctgc ccatcgcgcg
     1201 gctcctcggc tgaacgcacc gcgccggcct gcttcctacc gcgtcgtcac catccggccg
     1261 tatgccgaga caggaatctc tgatgaccac tcccttcgac tccgcccacc ccggccgcat
     1321 ttctctgcct gaagcttcgg cttatccggc tgctgttccc tttccatccc cgcgccgtgc
     1381 ggacgagacg attccgccgc caccgtccta cccgggcagc gcgacgccgg ccgaggccgc
     1441 tcaccccgcc gaggagccgg aacagcagcc cttttccgag aatcgcgcgc cgcaagaggg
     1501 tctcggccgc cgtgggcggg tgcacctcgc caggcggcag cggggcatcg acgcgacggc
     1561 tgtgggccaa ctgctgctgc ggttgccctc gttcctcgcc agcctggtga tcgtggcgac
     1621 actctcctac ctcctgttcc ccggcatggg atggttggga gtcctgctct ggctcggttc
     1681 aggtgccatg gcgtttcacc gacccaccga gagagccctg gcccgtcatc tgctgaacct
     1741 ccgtcacccc accccggaag agttgaaccg gctggaaccg ctgtggcggg aagtggcggc
     1801 gcggacgggt gtagagggcc gagcctacga gctgtggatc gaggacagcg atcatctcaa
     1861 cgccctggcc gcggcgggtc acatcgtggg cgtcacccgg ttttcactgg agcgtctgtc
     1921 tgatggtcag ctggccgcgg tcctcgctca tgagctgggg caccacgtcc gcggtcatgc
     1981 gtggtccttg atcctggggc agtggtatgc ggttccgggg tggtttgcgt gggccgctgt
     2041 gcggaggctg atccggctcg tcaccgtcgt gggccgtggg cgcatgagct tctgggcggc
     2101 cgtgctgctt cttgcggtgg gcgccatcgt gctggcggtc gcttgggaat actggtttct
     2161 caccctgacg ctggtggccg caccttatct gctcgctgcc gtgacccgtc ggaccgaact
     2221 gagggcggat caccatgcgg tagtggctgg tttcgggccg atgctcgccg aggtgttgca
     2281 catgatgcag gcggcggaac gggagggcgg ccatgcgacg gtttccgctc tttccggatg
     2341 cggcaagacg gttgcgattg acccgagaac cgccgctcgc ggcggtaggc ggagtttttt
     2401 ggacaagctc ctgtcctcgc accccgactg ctacacgcgc ctacaccacc tggcgccgta
     2461 tctggagcgg cgataaatct gctccaagtc ggatcctggg gttgtgctgc cgccacatcc
     2521 ttgcggggcc tggttcctcg atgagtgcga gcgggacagc ccctcgatcg cctggagtcc
     2581 agtaactcga ccccacgtaa gccggggcac atcaaagcct ctaccagagg cggagcggtt
     2641 caatccgcgt tcggagccgc gccttgtcgc cggcccggtt gattcttccc cgcgacacaa
     2701 cccaggaata attcacaaga gcgtcgtgcg ggaactcgcg aacgctccat atgacgggac
     2761 aggtgatcat gatgggcagc gacccgctca atctcgacgc ggcaggcgag tgggctggct
     2821 tgtggtggct gccggaggag cctgggtacc gggtgccagg cgtgctccgc tacgagcccg
     2881 agagcggctt gacgctgtct ttgatcggag cgttcgagga ccgggtcacg acgacgcctg
     2941 ctcccggtgt gctgatggtc catgagggcc gtcgaacgtg gagcgtgatc catggtgccg
     3001 ccgatcagcg cgagatcagt ctcttcggct gtttcgctca aggcggccga cgcactttcg
     3061 gtgcacgggt aaagaccccc gacaaacaga ccgtggtggc aacaactgcg ctcatcgggg
     3121 cacacgtcgg cggtgaagac gaggcggcgt tctccacaac agaggtgtcg gtggaggacc
     3181 tcgggcattg ggcggcatcg tcagtgttcg aggggttcct gggtgcgccc ggcgggcgtc
     3241 ccgatgggag tggcaccatc tccgtaaagc ccgtggaggt gcagtcggtc gaagtcgacg
     3301 ggactgagtt cgtgctcgcg caccgccata cgctgccgtt cttcgaccag cgtcgtggcg
     3361 gaaccgttgg tcgcatgagt gataccgcct acctgcagat cacccggcgc gaggcatact
     3421 cattgagtga tgcgatgggc tatgcccggt tgatacagga cctgatcgcc cttgccactc
     3481 accgtgctgc aggcatgatc tgggtacgcc tgaaactggc ctcggacgac accgtctcgg
     3541 agcccggcgg gctgcggccg gcgcggaatg tcgacgcgct gtattcgccc tctgtggtcg
     3601 ggaagcacga cgcgaaggca gccgctcatc atcgtgtttt cttcacgtgc gaggctctac
     3661 ccttcgagga gatcatcccc cgttggtgcg atatgcacga gcggctgcag tccgcgacca
     3721 acatggtgct ggggcttcgg tacgcgccgg cacggtacgt cgagaacaat cttctgactg
     3781 cagtgggagc ggctgaggtg ctgcaccgtg gttttgacat tgacgaaccg ccgatcccct
     3841 cggcggattt caaaccgatg cgcgaagcga tgctggctca ggtgcccgag aagcacaggg
     3901 atcggatccg agggttcctg cgcaatgacc cgacacttcg ggatcggttg tatgcactcg
     3961 cggcccgccc cgaccaggag gcgctgtcca cgctcgtgcc tgacgtggac cggtgggcca
     4021 ggcggacgac tcgagcgaga aacgacctgg cgcacgaggg gcgaaccccc aaccacgagc
     4081 tcgaggagct gatcgccatt gtggaggtga ccactgcggt ggttattctg aatctgctga
     4141 acgaacttgg attgccggcc gaacgccaac gagaggtcgt gcgtgaccac ccgcagttgc
     4201 gcgctacggc caggagtgca cgggactggc tgagcgggtc agaggcggac tcctgagtcg
     4261 gatcgttcgg ctctcgggtg aaggaaatct ccaagccact ggtaactctc tctcgcggag
     4321 atctggcctc agtggcgcgc cgcgaccgca gtgccccggg cccgctcgat ctcggcggcc
     4381 gggaacggcg ttcgcttgct ctcggtgagc agacggcggg cgaattcgcc tatgaccacg
     4441 gtggttcggg catgccggtc gatgatcgcg gcgattgcgc gcgggacgcc atcgggccgg
     4501 cggcccgcga tccactcacg caggaacacc tcatgtccca gacaaccgaa cagtccctca
     4561 ggcaggtggt gatggagcag atgcctcatg gtgtggcagc ggtcgtaggc gagatggctg
     4621 gcgaagaact ccgcctcggc ccctgacagt ttgaagccgg agctcagggc gagtccgaaa
     4681 tccgcgaagt acagcagtcg accgtcggtc aggacattcg cgaagtgggc gtcgaagtga
     4741 acgagtccgt gcgagctcat gaagtcagcc cctcgcgcca gggcctcctc cacccacagg
     4801 tacggggagc cgttcccgcc ctcaggcgcg gcggtccggt agtcgtgaag ccagtcgccg
     4861 agtgtctgcg ggacatgctc caggaagagc accaggctgg acgaagaccg gccgatggcc
     4921 tccagtcgct cgcgcacggc cgctgagccc tcccagtggg ccaccgtccc atcgataccc
     4981 ccgaacgtgt cggcgaagcc ttcgggaggg gagtcgggca ggacgcgcca gtggtacatc
     5041 agcggaaagc cctcgtacgc gttcccgagg acccagttgg tggtcatgac gtgcacggct
     5101 agctcccgcc aggccccgaa cccggctgag cccaccccgt actggtagaa cagcggcagc
     5161 ccgaagaggt tcgccgtcga ccgagcgtgc tccggccgca actcgatgtc cgtcagggga
     5221 acccgcttga cgaacacccg cgtgccgtcg atgtccaact ctgccgacct gccgccgacg
     5281 ccggatccga gcggggctgc ggcggccacg acctcgccga gccgccggtc gctcagcagg
     5341 gacagccgcg tggctacagt cccatacgtg gcgagccgcg cggcatgctg cgggtccggg
     5401 tggtgcatcg acgcctcctc ggtgccggaa tcaggggcgc tctgcgacaa gcgacgcagc
     5461 agccggtaca gagacggtaa agccgagttc agccggtctg ccggacttgg gtgaatgctg
     5521 tgcgagccag gagccatacc ccacgccgcg gcgcgcaagt atcgcccttc gggggcgcat
     5581 ccgccaccga tatgggaaag ctacgcccgt cccagtggtc gagctgacgc tgcgccaact
     5641 tccttgcgca tatgcctata cgctcccgca ggtcttcgga cgatcgtcta ttcccacagg
     5701 tttgagggtg ctcatggtcc aggagaagtc gccgtccgga ttgccgtccg tggcggtgta
     5761 cgcgtggctc ataccggtgg ttgcggccgt gacggtggcc ggcttggtgg aaccttctgt
     5821 gttcgctgcg gctgtgtgga tcggtgtgac ggctgtgggc gccgtggccg gtgccgcagg
     5881 tgtagccgtg cgtcggaatc ggcaggtcgc tcagctgcgg gaggaaagcc gagggcagtc
     5941 ggctgcgctg gcgcggcagc aggaagcgac cgcgcggctg gccgacagcc tggtgccgga
     6001 gatgctgacg cgcctgcgcc tggacgaggc ttcggaggag gccctcaact ggttgacagc
     6061 gcgctggtcg ggctcctaca gcggcctgcc gtccgagttc cagcaggccc actgggcggt
     6121 gttgcgcacc gtaatggacg ctgtggctgc ggaggagggg ctgagggact cggcgcagcg
     6181 tgccctggtg aacctggcca gacgtatgca ggccatcgtc caccagcagg cgcgggagct
     6241 gcgcgagatg gaggaccggc acggtcagga ccccgcggtc ttcggcgacc tcctgcggat
     6301 cgaccacaac accgcgctca ccggccggct cgccgattcc atcgccgtcc tcggtggtgc
     6361 ccggcccggc cggcagtgga accggccggt gccgctgtac agcgtgctgc gcggtgcgat
     6421 gtcgcggatc gtcggctacg agcgggtcga actgagcacc agcacggagt gcgccgtcgt
     6481 cgggccggcc gtcgaaccgc tcatccacgc actggcggag ctgctggaca acgcgacgcg
     6541 ctactcgccg ccccacacca aggtccatct cacggccgcg gaggtgcagt ccggggtcgt
     6601 ggtggagatc gaggacgggg gtgtcggcat gagcgagcag gcccggcacc tggccgagcg
     6661 gcgccttgaa caggcgcagc agggcttcga cttgggcgac ctgggggaga ctccgcggct
     6721 cggcctggcg gtggtggggc gcctgaccca ggcgttcggc ctccaggtct cgctgcgcac
     6781 ctccgcctac gggggcgtgc gggtggtgct cgtggttcct cagcagttga tcaccagtgc
     6841 ggctgaggcg tcgggtgtgg cgcacggtat cgggacgttc tccggtccgc gggcagcgag
     6901 ccagccgggc caggtggtgt cccgccagac ggcgaagcca ccggcggcga ggcgggttga
     6961 cgaagcgccg caagtggtcg agcggacggc gaacggactt ccccagcggc gccgcagaga
     7021 gcgggtggcg gaggcgcagg cacccgcggc cccgcccggc ctgcggaggg aactcaacgg
     7081 ccgccgggag agtggctgac cgccttcaag accggactgt cggcggaggg caccagtggt
     7141 ggcgacgacg ccgccgcgcc gagaggagaa cagtgagtca gcaggcggcc agcttggact
     7201 ggatgctcaa ggacctcgcg gagagcgtgc cgcagacccg cacggtcctc gtactgtcct
     7261 cagacggact gcgtatggga caccacggcg ggaccaccga gtcggccgag cggctggccg
     7321 cttcctgctc cggtttgcag agcctcgcca gtgcggtcgg cagcgagctc ccgcacctgg
     7381 cgggcaaaat gcagctggtg gtcatcgaga tggagggcgg cttcttctac ctgatggccg
     7441 ccggcccgag ggcctacctc gcggtgctcg ccgacgacgg cgtggacgcc gggctcatgg
     7501 gtcagcgcat gcgcgacctc atcgcccgtc tcggagcgca catcaccagc ccgccccgca
     7561 gtgacgggca ggccaggtga gcgactcccc ccaggacggc acggaggaac ggccggagcg
     7621 cctctacgtc atcaccagtg gccgttcctc cgcctccaac gacctcgacc tggtcacact
     7681 gatcgtcgcc aggaccgtcc ccacggccgg catgcagccg gagcacgcgg cgatcctgag
     7741 cctgtgtcag gctccgctct cggtcgccga gatatccgcc cacacagggc tgccggcgag
     7801 tgtcgtcagc gtcctgatca gcgacctgct ggacgcgcaa caggtgctca cgcgcccgcc
     7861 ggtaccgcca gcggatctgc ccgacctttc cctcatcgaa aaggtgatcc atggccttca
     7921 aaagctctga gctcgcagag ccccccagcg aggagcggct cccccacacg gcgtccgcgg
     7981 cggtcaaggt cgtgatcgtg ggcggattcg gggtcggcaa gacgaccatg gtcgggtcgg
     8041 tgagcgagat ccggccgctg accaccgagg agaccatgac ccaggccggc gtcggcatcg
     8101 acgaccgcgc cggcgtggag cacaagacgg ccaccaccgt cgcgatggac ttcggccgga
     8161 tcagcatcag cgacgaactc gtcctctacc tcttcggcac ccccggccag cagcgcttct
     8221 ggttcctgtg gaacggcctg ttcgagggcg ctctcggcgc ggtggtgctg gtggacaccc
     8281 ggcgcctgga ggacagcttc gacgtcatgg gccgcctgga ggagagcggg gtacccttcg
     8341 tcgtcgcggt gaactccttc gcgggcgctc cggatcacac gcttcaggag ctccgcagcg
     8401 cgctcgacct cccctccgac gtacccctga tgtcgtgcga tgcgcggcat cgcgactcca
     8461 gccgggacgt cctgatttcc ctcatgcact acctgcactc cctcgtagca acggagtcct
     8521 catgagcacg ccttcccacc tcccgccgcc cgggtgcccg gcccacgccc tgggccagga
     8581 cggcccgcag cgcctctacg ggccggccgc agaacacgac cccatggccc tgtacgagga
     8641 gctgcgcgcc aagcacggcg cggtggcgcc cgtactggtg catgacgacc agccggcctg
     8701 gctcgtcctg ggccaccggg agaatctgga ggtggcccgg acccccggcc ggttctctcg
     8761 cgacccccgc gcatggggtg ctgtgcagga cgggacggtg gtccccgaga agtacccact
     8821 cgcgccgatg gtgacctggt ggccggtgat caatttcaac gacggcccgg tcttcgaacg
     8881 gctgaggggc gcggtgctgg agtccctcca gcgcttcgac cggcgcggga tgcgccggta
     8941 cgtcacccgg ttcgcccacc aactcatcga tgccttcgcc tccaacggcg aggccgacct
     9001 cgtggcggag ttctccagtc agctgccgat gctggtgatg acgcagctga tcggtgctcc
     9061 ggaggaacac ggtccccggc tcgtccgggc cgtgcctgac atgctggagg gcacggagac
     9121 cgccctcgaa agcgatgagt acgtcacgaa gatgctgtac cagctggtgg agagcaagaa
     9181 ggccagccgg gggtacgacc tcacgtcctg gctgctcgac caccccgccg agctgacgga
     9241 cgtcgaggtt ctggcgcacg tgcgagtggt cctggtcgcg gcgtacgcaa ccaccgcgaa
     9301 cctgatcgcg aacaccctgc ggatggtcct caccgatccg cgcttccgcg cgaacctctc
     9361 gggtggccgt atgacgctgc cggaggccct ggagcaggtg ctgtgggacc agacgcccat
     9421 caacaccgtc ttggggcgct gggccacggc agacaccgtg ctgggcggtc agcagatcaa
     9481 gcgtggtgac atgctcctgt tgtccctcgc tgccggcaac gtcgatcccg cggtccggcc
     9541 ggacctgacc gcgccggtcc acggaaaccg ttcccacctg gccttcagcg cgggccccca
     9601 cgaatgcccg ggccaggaca tcggccgggc catcgccgac accggcatcg aggtgctgct
     9661 ggcgcgcctg cccgacatcg agctgaccgt gcacgacttc gagctggagc gccggggcac
     9721 gctgatgtcc cagcacctcg tacggctgcc ggtgcgcttc gcacccaggt ccgtcgtcgc
     9781 caccgcgcca cgggccgagc cggaaccgct gccgccgctc gctccgttga aggaggccgt
     9841 gcaggcagcg gcaggccggc cgcggtcgtc gcggtggtcg tggctgagcc gcctgttcgg
     9901 ccggcgttga cccggctgtg agggcccgca gcgcctcgct gcgggccctt cgccatgccg
     9961 ggcgccgggc ggccgggtgc gccgggccgg cgccggccgg tcactgctcc agttgctgcc
    10021 accaccagtt cagggacgga acggcgggcg gctcgatgct cggatcactc ggggagtcgc
    10081 tccagaccac gtcgaagctc gccccctcca ccggccaggc gttgcggttg cgggggctcg
    10141 cgtagcgggg ggcgacgttc tgccacgcga tgctgccggc gatgtagttc tggagcgagt
    10201 cgaggtagcg ctgaagctgc tcgtccgcgc cccgagcgag ctgtgcgcgc agacggagga
    10261 agagggtcat cacccggtcc cgcagggcga cggcctcagc gaccgcctct ccggggacgc
    10321 agccccgctc gtgggccaac acgttgatca ggttctgctc ccatggctcc tgatcgtcgt
    10381 ccttgttgta ggagaagaga tcgttgtcgg cggcgacgat ccaccccgct gcgtcggtca
    10441 cggcctggac cggggccgcg tagagggtgt tcggcggcag gtcgatcccg ttcgctgagt
    10501 cggcccaagt gaggctgaat cgggtgccgt tcgcgagcgc gccgagaccg gcgtaatcag
    10561 tgaggccggg catgcggccg cgctcggcct gcgccgtgcg ccagcccgcc ccgagcaacc
    10621 agtcccgcgc tccctctgcg aatctgcgca gctgaaaggg cgtgagcagg tcgtgtgtcc
    10681 gctgcaccag atcatccagc gccgaggtga ggggccccgg gggaaggagg tcgcagccgg
    10741 gcatctccag ggctcgggcc agccgggcgc cgtggtcggt gatcgacgcg gtatcggtgg
    10801 ccgccggccc ggagtcctgc cagtcgtcga cggcgttcgc ccagtaattc cacagcgtga
    10861 aagtcagtac gtgatcgacg gagccgtccg ggatgatccg gcaggagaag tcagcactgt
    10921 gcgtggccag tccccaggca cgttcggtgg catcgggata gatgccgaac gcgtcgatcc
    10981 attcaatggc gcgctgctcg atctccgccg ccttgggatg tcgggagggg gcgaaggggc
    11041 agaagaacgg cggaagttgc cagccgatgc gtgaggcgtg gccgtgttcg gcgatcacgg
    11101 tcagttgcct ccgagccgga aatgcagcag gcgggtttcc acggcgtggt cgcgccagat
    11161 acggaacagt ttgccgtgcg cgagagcgct ctgctggagc cgttcccgag accacgacgc
    11221 ctgttcgccg ccctgctcca ggcgcgtcag ttcagccgtg ttccaggcca tggactggag
    11281 ccagaactcg ctgactccgt ccgtgacgtc ctcgtcctgt tccagctcga agccggcggc
    11341 ctcagcggcg tggatgtact cggtgagggt gccgagccgc gtcttgtagt agtcgtcgat
    11401 ccagtccgtc cattccggac ggcagatgaa gtgctcctgg atgccgaacc accccccggg
    11461 ccgcagggcc ctcgccacca cctgaaacag ccgcttgcgg tccatgtagc cggagctttc
    11521 gatggcgtac gcggcgtcgt agcggcgctc gtgggtcaga tcgtggatgt cgccgacacg
    11581 aggggcgacg cggccggaaa cgcccgcctg ccgggcgagc tccctgatga ccggtatgtg
    11641 gtcgttcgcg acggtgagac cagtgacgtt cgcgccatgt tcctgcgccc agtagaggct
    11701 gccgccgccc agcccgcaac cgacgtcgag caggtgtgcg gggaaggact ggccgaccgc
    11761 ccaggtgcgt gcggcgtggt cgagaatcgc ctcctgggag ctgacgatcc ggttcttgag
    11821 gacccgctgg gagacggtcg tgttgagctt gaccgacgga tcgaacaggc ccacgtggaa
    11881 gtggacccgg ggccctggac cgtacttgtg aagtatgtcc tgggtcttgc gtgcgtagta
    11941 acgcggcact tccgtgtcat cgaacgtcgg tccatccgcg cgcgactgag tgacagggtg
    12001 agcgttcatc ggttctccgg attgtcatct gatccactcg gggggccggg ccacactgcc
    12061 cgcgactggc cggaatgatg ccatcgcgca gcgtacatcc ggacgttggt attcagttgt
    12121 gatcagcaac gatcctcccc atgttccggt cacgccacat cgctgacgga tctgccgcgg
    12181 cgagggtgcc gcgcggaggt cccaccgcgg acggctggcg gcggagggcc tttcgtgcct
    12241 gccgcgcaca caacggagcg ccggccgcgg tgtgttgggg cggccggcgc tcgcaagggt
    12301 ctgggcatca atcgctccga tgccgtgatc acaccctcat cggtgttcgg ggttttcgta
    12361 gtcgtggcgg cagccggcgt cccatgcggt gcgctggttg ccgtaggcgg ggatgccgcc
    12421 ggcgtccttg agcgttctgg ccacgtgcag caggttccag gtcatgaagg cggtgttgcg
    12481 gttggtgaag tcgttgtccg ggccgcccga gccggggtcg aggtaggagg ggcccgggcc
    12541 cgcctcgccg atccagccgg cgtcggcctg cggggggatg gtgtagccga ggtgctggag
    12601 gctgtagagg acgttcatgg cgcagtgctt cacgccgtcc tcgttgccgg tgatcagaca
    12661 gccgccgacc cgcccgtagt aggcgtactg gcccgactcg ttgaggaggc tggagcacgc
    12721 gtagagacgt tcgatgaccc gcttcgtcac cgagctgttg tcgcccagcc agatggggcc
    12781 ggccagcacg aggatgtcgg ctgccgtgac ctgttcgtac agccccggcc aggcgtcggt
    12841 ctgccagccg tgctcggtca tgtccggcca gacgccggtg gcgatgtcat ggtcgacggc
    12901 ccgtacgaca tcgacgtgga caccctgcgc ttccatgatg cccacgctgc ggtcgatgag
    12961 cccttgggtg ttgctccgct ccggtgaccg tttgagcgtg cagttgaaca ccagggcccg
    13021 caggtcgtcg tagcgcgccg gaggcagatc ggtggaaggc gactgggcgg cggacacggt
    13081 gcactcccgg gggtcccgcc accgtgcggt tcacggcggc acagagctgc ccatcgtgct
    13141 ggtccggccg ccgctccagc caccgcggca cggcccgttc gccgacgacc accccgacag
    13201 tcgaatgccg ggcacccgcc tcgcccggct tcgatccggc agcccgccgc gcgccggcgg
    13261 gcggcaggag ccgtcgccga agggcccggg tggggccggc gttcgggacg ggtacggccc
    13321 ggcggggtcg ccgccgggcc gggtggctca tgggtcaggc tgtcgggtgg gccggagtcc
    13381 gttgtgccgg gggagcggtc ttcgttccct gtccggcagc gcaggcgccg gccgcgcagc
    13441 tggtgagcca ggcgtcgaag tcggcgtcgt agcgggtgcc gatatcggtg ctgtagacgg
    13501 cgtagccgcc ggcgtagtcg ccggtacgga agtgcccgag cacggtggcg acgtccgagg
    13561 ggtgcttctc gaccatgtag cgggccgcga ggtagcccca ggggtaggtg cgggtgacgt
    13621 cgctgttgtc gtaggtgctc tggaacaacg tgctcagtgc gtacgtgtgc ttgccggcct
    13681 cggtgaccgc ctcggtgtcg gtgacgtggc ggtagctgta cgagacgtac tcggcgaggc
    13741 cctcgatcca ccagatgtcc gggaccgacg tctgccggcc gaagtcgccc ttcatgtcgt
    13801 cacgggcgtc gaggtagtgc gtgtactcgt ggttgaggtt ccagatccgg gccgggaagc
    13861 cgtcgtcgga gtccttctgg tacatgatgg acaggggctg gttgtcgggc ttggcggggt
    13921 ccccgaccag ggtgatgccg ccgttgtcgg tgtcgacgcc gaagatggcc ccggcgtagg
    13981 tccggtagtc gttgcgactg ccgaagacga cgagctggac ggtggattcg tactggccgg
    14041 gtatcgggcc gtcgtccttg accaggtcgt ggaagtacgg gccctggccc aggatgctgg
    14101 cgcaggtcgc atcgagttcc gcgggggtca gcgactgcgc ccggacggtg tgcgtcgcat
    14161 cgcaggcccg ggtgaccgga agtgccgcct cggtcagccg gccgggcagg tcgcagacgc
    14221 cgtagtacga gcagttggcc ttgtcgtagg cgtcggcctg ggaagcgacg gtgacccaca
    14281 ggggcgcggt cgggccggtg accttcgagg cgtccagcag acccttcatg agcggccgga
    14341 ccctgtcctg gagggccggg tgctcgacgt accgcgcgac gttcatcccc gcgttggagt
    14401 cgaggtagga attgccggtg cccagcaggt ccaggtggtc gagcgcgaag gagttgaggg
    14461 tgtcgatgat gctcgggtcg gcggtcaccg cgctgacgta gtcggggttc cagttcccgc
    14521 gccagagagg tgtgtagacg tcgttgacgg ccgccagcat gctggggatg gtgtcgtagg
    14581 agctgttgta cccgccgagc acctgcttgt aggtgttcag atagcgggcc tgttcgtcgg
    14641 cgctgtccgt gaggatgagg acctcgccca ggacgtcacc gttggccgac gtcacgtcct
    14701 gggaatgcgc gttggcgaag aaggcgtcca ggccgctccg ggtggcagct gccagcgtcg
    14761 ggccgtaggt cccgacatcg tccggatggt tggactgcac gtaatagccg gcgcgcagga
    14821 acagcacgag ctgccacacg tggtccgagt tgtcaccggg gtacgtcgtc gccccgctct
    14881 gaaaggcgtt ggcgagggtg accatctggt cctcgcggaa aacgtcgtgc gcgtctttgc
    14941 cggtgacgct gaacagtgtg ttgacgcagt ccgtggtcgc ggctttgacg aacgtgacca
    15001 gttcggatcc ggtccggctg ccgaaatcgg acggactgca ggaggctgtg gggtggtgct
    15061 ttccgccctt gtgccgtgcc gccgcagtcg aagaaatggg gggattcttc gcgctgagcg
    15121 ggcggagtcg ggcgacgccg agcggccggc cctggagtgc gggcctttcg ttcgtgcctg
    15181 ttgccgggcc ggtcgggggt acggcgtggg ggacgggcgg ggacgcggtt gcgggccgga
    15241 cggcggccgg cgcgtgcggg gccgcctgtg cgggcgcggc ctgtgcgggc gcggccagca
    15301 ggccggctgt ggcgacgcag gcggccaggc cgccggtcag agatctgggc agggggaggc
    15361 ggtagcgcat ccgtgctcct ttgtgggcag atgcgcctcg aggtcgatct gaggcgtgtg
    15421 tggcaccttc tcagcgcacg cgacgggcaa caataaggtg tgacatagca cttgagctga
    15481 acgcgccata acatccgggt ggcggaggcg gtggcggtgg cggagtccgg ctggtcctgc
    15541 tcccgcggtg ctcggcggtg gcagagggcg tcgacggtgc ggacgtcgac ggagaggacg
    15601 gcgacggaga ggacggcgac ggtgagggcg tcgatgcggg aacatcgggt ccgcactcca
    15661 tggctccggc gctgataccg cgaccccgcc ggagcgctca gctagcgccg ggccacgctc
    15721 caggtccgtg cggcccacgt gcggaagtgc ggcgactgcg cgatgagagc gcggtatgcc
    15781 gccgcggcgg aggcgaaaag cgcgtccccc acctcgtcgt cgaggctctc ccgtcgccag
    15841 gccagcacgt agcggcacca caggggagtg ccgatcagcg gcctgacgag gacgccgggg
    15901 atcggccgga gcgtcgcttg cacgatggag accccgatgc cttcgccgat catgttctgc
    15961 aactgctgct gatcgcccag gaattcatgg accgccgccg gggtgaaacc ggccgcgcgg
    16021 caggcggcgt agaacactcc cggccagccc gccccgtcgt ccggggtcag gaaccacgcg
    16081 tcgtcggcca ggtcggcgag tgccacctcc cggcagtgcc ggagccggtg cccggccggc
    16141 agggcgacga aggacggctc ggtgacgatc ccgcggtgcg ccacggcggc cgagtgccgc
    16201 agttcgagcc cggggtagtc cgcggcgacc gcggcgtcca gctcgccctg ctccaggagt
    16261 tcgatgatct ccgaggacgg atacacactg ctcaccgtga gcgccaggtc gggcagccgg
    16321 ctgcggagcc ggatgagcat gccggcgagg accggcgtgt tggtcgcggc cagccgcagg
    16381 gggcggggcg ttctcgcgcc gtctgccgcc ggccggcgcc cgatcgcggc cgcgcgggcc
    16441 aggacgtcac gggcctgggc gaggacttcc gtgccgtacg gcgtcagctc cacgcccgag
    16501 gagttccgct cgaacagcga gtggccgaag tactgctcga tgcgctggag ttgggtgctc
    16561 atcgccggct gcgagtaccc caggtccgac gcggcccggc ccaggctccc ggcatcggcg
    16621 atcgcacaca gcaccctcag atgccgaagc tccagctcca tgcccacgct cctcccgtcc
    16681 acgccgccgt gcccgaaccg cccggggcca cggggcgacg tgccgacccc ggttacgcga
    16741 ccctcgtccc accgttcgac agggaagcgc actcatcatg cccacgccat ccttctcgcg
    16801 gtgggtgcgg cggcccggaa cgttctccgg gctgccgtac cagggcttcg gcgtagtcgt
    16861 gtgaggggcg ttttgtgatc accagtgcgt cgccgtcgac gcgggtcagc agtcggcgca
    16921 ccgtcgattc cgtgggcacc agccgcccgg gcagcagtgg atcacgacgg ataccgaggc
    16981 gttcgagcac gcaggtcggg gcgtcggcga tgcactccac gcctggatcc gcacctaacc
    17041 gagtgctgga gggggctcgg ccggccggcg tccccaggcc gagatcaacg gcgcgagtgt
    17101 caggtcgagt tcgcccgcgt ggatggcggc caggtgcgcg tcgatctcgg cgtcgtcggc
    17161 caggccggcc gcgagcagct cgccgcgcac gtgccggatg gtcgccgcct ccagccggtg
    17221 gcaagccggc ccgccgaccg ggaaagagcc cctcgcggcg acatctacca agccggcctc
    17281 acgcaatgcc cgcggcagtg tccggccgta gtgcaggtcc gcgccgcggc gcttcagcag
    17341 ctcccggacc gcgtcgcgca gccggttggc ccgccgctgc gcagggccgc tgtcgtccag
    17401 gcacgccagt ggctgcagag cggtatcggc gtcctcgacc agcagccagc cgccgggccg
    17461 tagcgctgcc gccatcgtgg ccaaggctcg agcccggtcg ggtacatgga ccagcacgag
    17521 ccgggcgtgc accagatcga acgtcccggg ctccgggggc ggatcagcgg cgacgtcgtg
    17581 ctggcgcacc tcgtacccgt cgcctgcctt cagccacgac gggtcgatgt ccgtggccag
    17641 cacgtgcccg gtcggaccga cggccgccgc gagcgcctcc gggataccgg ggccaccggc
    17701 ccccacttcc cagcagcgcg agccggccct gacccccagt cgatcgaagt gcccgcgcgt
    17761 cacaccgtcg aacagctcgg ccagccaaac gaatcgctcg cctgcctcgg cgcgcgcgtt
    17821 gtccagcagg tacccgcggg cgggagcgga ctctccaccc agcgcggtag tcccgtcttt
    17881 cggatccggt cggccaccgg cgtgcggcgg gcggggcgag gaggtcatgg ctacatggtc
    17941 aaccttcccg ggctaccggc gccatgacga cgggagaggg atgcctcaca cggccagtga
    18001 accccgcacg tacagcgcgg tttctgcacc gtggcgcgcc aatgaattgc cctccagagc
    18061 atcaaccgct accggcttct gctcccaccc tggccggttc ggagatgggc ttccgcgagc
    18121 gcgggcgcgg gtgcgtacgc gaaaggcccg tgccggtcgc gcccccggca cgggcccctc
    18181 gtgttgcggt aggtcaggcg ggcgtaggca attcagccgc ctggcccggg tgcggagcgt
    18241 gcggtcgtag ggcccgctcg gcgaggaagc cgaagatcac gccgaaggcg gtccacagca
    18301 gcgcctgaat gccgagcgag gcgagacgga actgccacag cacggtggcc gggaagtcct
    18361 tgggcgtttc gttgaccgcg ggaagaaacg ccatggccac ggcgatgacc gcgaggaaac
    18421 ccgccgtcgc ggcgagggtg gcgttccagt tgccgagccg tccggccagg cggcggccga
    18481 cgatcaccgc gccgacgccg accagcacgg tcaacgcgat catcccgaag tacagcgcgg
    18541 tgcgcttgcc gatggtgtcg ggctcgttgg accccggtgg attggccggg tacttcaaga
    18601 acggcaccag gtagacggtg acgaaggcgc tgacggcgat gagggcggcg gtcgcccgtg
    18661 ccccgaatcg gccgatgcgc cccagggcgc agcagaacgc cagtgcggcg atcccgccca
    18721 ccgcggtgcc gaacaccagc accgcggtgg ccaggccacc agtggactgc accgcacggc
    18781 tgacgagttc catctcgtgc tcgtgggtgt gggcgtcctc gtaggcgatg cccgcgttca
    18841 ctcccggctc gccgatgagg taggcgagcc cgaaggccag cagacccgcg gccaggccgg
    18901 ccagcatgcc gcggaccagc agcgtacgga cggtggcgga attcatgctt ctgtcccgcc
    18961 cgtcgtcagt ggcaggggaa tccgagcagg tgccggccat cgtgcaccca ctcgtggacg
    19021 cccgcgccgg agagaaggga ggtggcgccc tgctcggcgc cgacgaaata cagcaggacc
    19081 agcatcagca ggccgaagaa cgccgcccag ggcagaatcg cccggatcgg cagcttcgtc
    19141 acggccggcg aggacagggg ggcaggggcg gctgcggtgt gagccacggc ggtacctcct
    19201 cgggaacacg cgtcccgttc gttggagcac gcgacgacgg cgccgggtct gactcactga
    19261 acaactcctc gtggcgcgag ggtcgtacag cacacagtgg cgcgaccgtg ccgggcttgc
    19321 accggacttc cgttcgcacc gtcgtcctat cgcatcagac ggtaccggca gcgacccata
    19381 caagccaaga tggcctgcct ctcttcctgc tgcccccgag cctcgtccca ggggcagggc
    19441 ctagccttcc gcccatgacg atcaggctga ccttgctcac cccggccccc gggcccgcct
    19501 tgcgcgaggc acgcgtggat gacgacggcc cgttggacga gcccggccgg cagcaggccc
    19561 acgcgatcgc cggtgacctg ccgccggccg accgccacct ctccggcccg agccggcgct
    19621 gccgggaaac cgccgccgcc ctcggcgtgg accccgcggt cgaccccgcg ctgcgcgacc
    19681 tcgacctggg cacctggcgc ggccgcaccc tcgacgaact ggccaccacc gatccggccg
    19741 cgctggcagc ctggaccacc gaccccgccg cggcgcccca cggcggcgaa tccatcgacc
    19801 agttgtgccg gcgcgtcgcc gactggatgg atcagctgcc cgacgacacc ggccgcgtcc
    19861 tggccctcgc ggacccctcc gtggcccgcg ccgccgtcgt ccacgcgctg acggcgcccc
    19921 ggtacgcgtt ctggcgcatc gacctgcggc cgctcacccc cgtccacctc acgggccggg
    19981 ccgaccgctg gaacctccga ctcgggtgag ggtgctcgtc ctcggcaggg gccgggtgtc
    20041 ccgcggatac ggggtagggg tatcgtcctc ccttgtcgtc atccctagtc gtcagtcgtc
    20101 gtccccagtc gtcgtcctcg cgcgctgcgt cgtcggcgcg cacagagatc agagaagggc
    20161 cgcctcgtgg accgcccgat ggaccgcacc ggaacgccgg gcaggccgcc cgtgactcgg
    20221 ctcatggcgg tgtgcgtcgt cctcgtgggg ctgttcctga tgcatgggtc gccggcttcg
    20281 gctgccggcg ggtgccacgg ggcgatggcc ggtgccatgc ccggggcgca cggggcgccc
    20341 gctgcgagcg gcgcgcacgc ggaagcgctg ccgacagggc accgcaccga cagctcccct
    20401 ctgacctcgt ccggccccac cggcacactg tgcgtctcaa cccccgcaca gcaatccctg
    20461 ccactgccgg cactcggcgt gctggctgcc gtcggcctcg cggggtggga gcccctcggc
    20521 cgacggctga ccgctgcggt cacgcggtgg agagggccgc ccagaggcgg gcgaggagtg
    20581 ctgctgcgcg tgtgcgtcac gcggacgtga caggtgcctg acggacccgg actcatcccg
    20641 ggcccgatac ggcgtcctgt tcacccgcgt accgcccgag cgtggtgcgc ttccctcgaa
    20701 agactctcgc gatgtccctc gtttcccgct ccaccgcacg ccgccgcacc acggtcgctg
    20761 ccgccctcgg cggcgccctc gcgctggcat tgaccgcgtg cggctctccc gcctcgcacg
    20821 actcgtcgat gccggggagg catacgccct ccgcggcgtc cacggcccag ggcacccacc
    20881 acgacgattc cgccatgccc ggcatgacca tgaacaccgg ggacggtctg gtcaccaaga
    20941 aggacggcta cacgctggcc gcgaaggccg ccacgctgcc tgccggaaaa gcgaccagct
    21001 accggttcgc catcaccggc ccggacgcca agccggtcac cgacttcgcc gtcgagcaga
    21061 ccaagcggct gcacttctac gccatccgct ccgacctg
//
