LOCUS       NZ_CP019779            21059 bp    DNA     linear   CON 14-MAR-2024
DEFINITION  Streptomyces sp. MOE7 chromosome, complete genome.
ACCESSION   NZ_CP019779
VERSION     NZ_CP019779.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. MOE7
  ORGANISM  Streptomyces sp. MOE7
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8399509)
  AUTHORS   Elnahas,M.O., De Leon,K.B., Amin,M.A., Hussein,M.M.D., Ali,A.E. and
            Wall,J.D.
  TITLE     Complete Genome Sequencing of Streptomyces sp. Strain MOE7, Which
            Produces an Extracellular Polysaccharide with Antioxidant and
            Antitumor Activities
  JOURNAL   Genome Announc 5 (22), e00442-17 (2017)
   PUBMED   28572320
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8399509)
  AUTHORS   Elnahas,M.O., De Leon,K.B., Amin,M.A., Hussein,M.M.D., Ali,A.E. and
            Wall,J.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-FEB-2017) Biochemistry, University of Missouri
            Columbia, 117 Schweitzer Hall, Columbia, MO 65211, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera Assembler v. 8.1
            Genome Coverage                   :: 180.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002090335.1-RS_2024_03_14
            Annotation Date                   :: 03/14/2024 02:19:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,435
            CDSs (total)                      :: 7,344
            Genes (coding)                    :: 7,005
            CDSs (with protein)               :: 7,005
            Genes (RNA)                       :: 91
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 339
            CDSs (without protein)            :: 339
            Pseudo Genes (ambiguous residues) :: 0 of 339
            Pseudo Genes (frameshifted)       :: 230 of 339
            Pseudo Genes (incomplete)         :: 155 of 339
            Pseudo Genes (internal stop)      :: 7 of 339
            Pseudo Genes (multiple problems)  :: 47 of 339
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:50:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7077369
            Orig. end                         :: 7098428
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP019779.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Judy D. Wall 117 Schweitzer
            Hall Columbia, MO USA 65202.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21059
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="22"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21059
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21059
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11059](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11059)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(263..1228)
                     /locus_tag="STRMOE7_RS31095"
                     /old_locus_tag="STRMOE7_31090"
     CDS             complement(263..1228)
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018519857.1"
                     /locus_tag="STRMOE7_RS31095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_31090"
                     /product="CoA ester lyase"
                     /protein_id="WP_084775017.1"
                     /transl_table=11
                     /translation="MTAPGNRLRPRRSCLAVPGSNPRFLEKAQGLPADQVFLDLEDACA
                     PLAKEGARHSIVEALNGGDWTGKTRVVRVNDWTTHWTYRDVITVVEGAGPNLDCIMLPK
                     VQDAQQIVALDLLLTQIEKTMGFEVGRIGIEAQIENAKGLVNVDAIAGASPRLETIIFG
                     PADFMASINMKSLVVGEQPPGYGADAYHYILMRILMAARTYDLQAIDGPYLQIKNIDGY
                     REVAGRAAALGFDGKWVLHPGQVDAANEVFSPSQEDYDHAELILDAYEWHTSEAGGKKG
                     SAMLGDEMIDEASRKMALVVSGKGRAAGMIRTSKFEAPEA"
     gene            complement(1225..3270)
                     /locus_tag="STRMOE7_RS31100"
                     /old_locus_tag="STRMOE7_31095"
     CDS             complement(1225..3270)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049399.1"
                     /locus_tag="STRMOE7_RS31100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_31095"
                     /product="protein meaA"
                     /protein_id="WP_084775018.1"
                     /transl_table=11
                     /translation="MTERQKDRPWLMRTYAGHSTAEASNELYRRNLAKGQTGLSVAFDL
                     PTQTGYDPDHILARGEVGRVGVPVSHLGDMRRLFQDIPLDQMNTSMTINATAMWLLALY
                     EVVAEEQGADISKLSGTTQNDIVKEYLSRGTHVFPPGPSLRLTTDMITYTVAHLPKWNP
                     INICSYHLQEAGATPVQEIAYAMSTAIAVLDAVRDSGQVPPEKFGDVVARISFFVNAGV
                     RFVEEMCKMRAFGRIWDKITRERYGIENEKQRRFRYGVQVNSLGLTEAQPENNVQRIVL
                     EMLAVTLSKDARARAVQLPAWNEALGLPRPWDQQWSLRIQQVLAHESDLLEYEDIFAGS
                     HVIEAKVDALVTDCLAEIERIQEMGGAMAAVESGYLKSQLVSAHAERRARIEAGEEKIV
                     GVNCFEGTEPNPLTADLDTAIMTVDPANEARVVQALHEWRDNRDETRAQEALSVLKKTA
                     AGDANLFAATLECARAGVTTGEWSWALRDVFGEFRAPTGVSSAPLAVAAEAGSPLAAVR
                     EKVAKTAAELGTGKLRLLVGKPGLDGHSNGAEQIAVRARDAGFEVIYQGIRLTPEQIVS
                     AAVAEDVHCVGLSILSGSHAELVPDVLDRLRRTGVDASPGPDGPGDAPIPVIVGGIIPS
                     ADATALREAGVAAVFTPKDFGITEIIGRIVDEIRKANQLDPLEVPA"
     gene            complement(3312..4648)
                     /gene="ccrA"
                     /locus_tag="STRMOE7_RS31105"
                     /old_locus_tag="STRMOE7_31100"
                     /pseudo=""
     CDS             complement(3312..4648)
                     /GO_function="GO:0043880 - crotonyl-CoA reductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (52-413). E-value: 7.3e-25.
                     Score: 79.7. Matches aSDomain:
                     nrpspksdomains_STRMOE7_RS31105_PKS_ER.1"
                     /codon_start=1
                     /gene="ccrA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890465.1"
                     /locus_tag="STRMOE7_RS31105"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_31100"
                     /product="crotonyl-CoA carboxylase/reductase"
                     /pseudo=""
                     /sec_met_domain="ADH_N (E-value: 8.8e-06, bitscore: 24.3,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 3.2e-31, bitscore:
                     106.8, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKILDAILSPDATSADFAALPLPESYRAVTVHKDEAEMFAGLPT
                     KEKDPRKSLHVEDVPVPELGPGEALVAVMASSVNYNSVWTSIFEPLSTFGFLERYGKLS
                     PLTKRHDLPYHVIGSDLAGVVLRTGPGVNAWGPGDEVVAHCLSVELESSDGHNDTMLDP
                     EQRIWGFETNFGGLAEIALVKSNQLMPKPKHLSWEEAAAPGLVNSTAYRQLVSRNGAGM
                     KQGDNVLIWGASGGLGSYATQFALAGGANPICVVSSDQKAEICRKMGAEAIIDRNAEGY
                     KFWKDERTQDPKEWKRFGKRIREFTGGEDIDIVFEHPGRETFGASVYVTRKGGTITTCA
                     STSGYMHEYDNRYLWMSLKRIIGSHFANYREAWEANRLIAKGKIHPTLSKTYTLEETGQ
                     AAYDVHRNLHQGKVGVLALAPRRAWECAMRKCAPSTSTPSTGSGTS"
     aSDomain        complement(3410..4492)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STRMOE7_RS31105_PKS_ER.1"
                     /evalue="7.30E-25"
                     /label="STRMOE7_RS31105_PKS_ER.1"
                     /locus_tag="STRMOE7_RS31105"
                     /protein_end="413"
                     /protein_start="52"
                     /score="79.7"
                     /tool="antismash"
                     /translation="SLHVEDVPVPELGPGEALVAVMASSVNYNSVWTSIFEPLSTFGFL
                     ERYGKLSPLTKRHDLPYHVIGSDLAGVVLRTGPGVNAWGPGDEVVAHCLSVELESSDGH
                     NDTMLDPEQRIWGFETNFGGLAEIALVKSNQLMPKPKHLSWEEAAAPGLVNSTAYRQLV
                     SRNGAGMKQGDNVLIWGASGGLGSYATQFALAGGANPICVVSSDQKAEICRKMGAEAII
                     DRNAEGYKFWKDERTQDPKEWKRFGKRIREFTGGEDIDIVFEHPGRETFGASVYVTRKG
                     GTITTCASTSGYMHEYDNRYLWMSLKRIIGSHFANYREAWEANRLIAKGKIHPTLSKTY
                     TLEETGQAAYDVHRNLHQGKV"
     CDS_motif       complement(3914..3976)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_STRMOE7_RS31105_0001"
                     /evalue="1.80E-03"
                     /label="PKSI-ER_m5"
                     /locus_tag="STRMOE7_RS31105"
                     /protein_end="245"
                     /protein_start="224"
                     /score="11.1"
                     /tool="antismash"
                     /translation="GDNVLIWGASGGLGSYATQFA"
     gene            complement(5204..6007)
                     /locus_tag="STRMOE7_RS31110"
                     /old_locus_tag="STRMOE7_31105"
     CDS             complement(5204..6007)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602149.1"
                     /locus_tag="STRMOE7_RS31110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_31105"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_107487598.1"
                     /transl_table=11
                     /translation="MSQPARTQPSDTPDATSPGTRRAAAQRLKMRRELSAAAMELFATK
                     GYEGTTVDEIAAAAGVARRTFFRHFRSKEEAIFPDHDDTLVRAEAVLDAAPPHENPLDT
                     VCRGIKEVMRMYAASPAVAVARYRLTREVPTLREAEIASVARYERLFTRYLLGHFDEGA
                     HREGDDDPLLAEVAASAVVTAHNHVLRRWLRAGAEGDVEAQLDHAFEIVRETFGAGIGA
                     GRTTTGEQPAAAVSREGEVLVAVARTDAPLEEVMRTIRKAIKERK"
     misc_feature    6018..6036
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.51"
                     /tool="antismash"
     gene            complement(6144..7964)
                     /locus_tag="STRMOE7_RS31115"
                     /old_locus_tag="STRMOE7_31110"
     CDS             complement(6144..7964)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602148.1"
                     /locus_tag="STRMOE7_RS31115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_31110"
                     /product="3-hydroxyacyl-CoA dehydrogenase family protein"
                     /protein_id="WP_084775020.1"
                     /transl_table=11
                     /translation="MGPHSTPDLPTEAAPLPLATVAVVGLGTMGTGIAEVLTRAGREVI
                     GIDTDATAARHAVAALEAATAHAVRRERITERERQDALARFRTFTDLQAAADADLVIEV
                     VPEDYDLKRQVFAELDAVVRPDTILATGTNALSVTRLAADSQRPERVLGVHFFNPAPAM
                     KLVEVVSSVLTAPTAVAAVTQLARDLGKDPIAVGDRPGFVADGLLFGYLNQAAAMYESR
                     YATREDIDAAMRLGCGLPMGPLALLDLIGVDTARTVLEAMYADSQDRLHAPAPILGQLA
                     EAGLTGRKAGRGFYTYEAPGSGTVVPDAESPAAADALGTGRTVSSVGVAGSGTMASGIA
                     EVFAKAGFKVVLAARSPEKAETAKARIAKSLGRSVDKGRMTAEARDAALAAITPAGSLD
                     AFGDVDLAVEAVAEDLAVKQELFRTLDKVCKPGAVLATTTSSLPVVACARATSRPQDVI
                     GMHFFNPAPAMKLVEVVRTVLTADDVHATVRAVCAKVRKHPVDCGDRAGFIVNALLFPY
                     LNNAIKMVEQHYATLDDIDAAMKLGGGYPMGPFELLDVVGLDVSLAIEKVLHAEFRDPG
                     LAPAPLLEHLVAAGCLGRKTGRGFREYARR"
     misc_feature    complement(8251..8268)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 17.03"
                     /tool="antismash"
     gene            8355..>8942
                     /locus_tag="STRMOE7_RS31120"
                     /old_locus_tag="STRMOE7_31115"
                     /pseudo=""
     CDS             8355..>8942
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004945459.1"
                     /locus_tag="STRMOE7_RS31120"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_31115"
                     /product="HEAT repeat domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEDEFHELTDRVRAELRSPQDLVAYERLLGLARKNTPAGREELAR
                     MLVAVERPLWAREIAAFILGCAGDKRAFETLVLLLNYRDPVRCATAAHALSRLGDPRTA
                     RAAAALATNPLRTAYALHPVRLLAELRAPQSVPALIATLERLLTPHNPYWRVALACVEG
                     LGALGDRRAVPVLTAAVAHPRLAAAAAASLARL"
     misc_feature    complement(8357..8371)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.06"
                     /tool="antismash"
     misc_feature    8436..8438
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(9093..9968)
                     /locus_tag="STRMOE7_RS31125"
                     /old_locus_tag="STRMOE7_31120"
     CDS             complement(9093..9968)
                     /EC_number="2.1.1.255"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0042214 - terpene metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574303.1"
                     /locus_tag="STRMOE7_RS31125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_31120"
                     /product="geranyl diphosphate 2-C-methyltransferase"
                     /protein_id="WP_084775021.1"
                     /transl_table=11
                     /translation="MTIAPAGTARTPVPTQSTYQSRVADYWNAEENPVNLELGKIDDLY
                     HHHYGIGDADRSVLDEPDPDRRRERVTAELHRLEHAQAELLASHLGDVSAADRVFDAGC
                     GRGGGSVVAHQRYGCSTDGATISAKQADFANEQARKRGIDDKVRYHHRNMLDTGFTSGA
                     YAASWNNESSMYVELDLLFAEHARLLRRGGRYVVITGCYNDAYGRASREVSLINAHYIC
                     DIHPRSAYFSAMARNRLVPVHVEDLTEAALPYWELRREADHLVTGIEDTFLNAYRNGSF
                     QYLLIAADRV"
     gene            complement(10001..11059)
                     /locus_tag="STRMOE7_RS31130"
                     /old_locus_tag="STRMOE7_31125"
     CDS             complement(10001..11059)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018093087.1"
                     /locus_tag="STRMOE7_RS31130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_31125"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_084775022.1"
                     /sec_met_domain="T1TS (E-value: 1.2e-54, bitscore: 185.1,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPPKTTAAFTLPGPPKLTRTPRTRPGGAVPGLRYRPAAPANPE
                     KVEEIDRRLETWARELDLFPSEWSGDFAEFQFGRAVVLQHPGAADLERLTVAGKLLLAE
                     NIVDNCYCEEDEGRGGAHRGLGGRLIMAQSALDPYHGTPEHEEEWRRGVQADGPLRSYH
                     VALKDYAALATPSQTDRFVHDIARLHLGYLAEAAWAETRHAPKVWEYLVMRQFNNFRPC
                     LSIVDAIDGYELPEALYARPEIQRVTALACNATTIVNDLYSFTRELASDPDHLNLPQVV
                     AANDQRGLKAAYLKSVEIHNQIMEAFETESALLAATSPVIERYLQGLADWVSGNHEWHA
                     TNTDRYQLPNYW"
     gene            complement(11079..12521)
                     /locus_tag="STRMOE7_RS31135"
                     /old_locus_tag="STRMOE7_31130"
     CDS             complement(11079..12521)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576907.1"
                     /locus_tag="STRMOE7_RS31135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_31130"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_084775023.1"
                     /transl_table=11
                     /translation="MSVPDSVTGSATDEPALEPSADGAPTSLGTQAARQLATTTKSEPQ
                     MQAITSRWLLKSLPWVDVKGGTYRVNRRLQLRVGRGRVEFEQNGADDIRVIPRTLTELP
                     ALRGYDDGEVLKELAGRFRAREVRAGQVLFEAGQPATEAYLVVHGRFARYTAGKYGEEE
                     IIGVVTDGDQMGDEALGRPDPRWRSSVRAETAGVLMVLPWDVLREFTDRVPSLAAHLTA
                     YAERQQLPMNRKGEAEVPVQAGHVGEPRLSGGFVDYDLAPREYELSLTQTVLRVHSRVA
                     DLYNEPMDQTQQQLRLTVEEIRERQEWELVNNREFGLLHNADYGQRISTYTGPPTPDDM
                     DELLSMRRKTRLFLAHPKAIAAFFRQCNKRGLVPGTANVDGHEVPAWRGVPIFPCGKIP
                     ISESHTSSIIALRTGEADQGVVGLYQTGLPEEFQPGLNVRFMGIDQAAVIKYLVTAYYS
                     LAILVPDAAGVLENVQIGRNAD"
     misc_feature    complement(12660..12680)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 22.39"
                     /tool="antismash"
     gene            complement(12768..13307)
                     /locus_tag="STRMOE7_RS31140"
                     /old_locus_tag="STRMOE7_31135"
     CDS             complement(12768..13307)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090472.1"
                     /locus_tag="STRMOE7_RS31140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_31135"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_084775024.1"
                     /transl_table=11
                     /translation="MTEADVAGVSAVRVRGWQAAYRGLMPQAYLDAMSVTADAERRRSW
                     FARRPPDVADLVAEAAGEVVGWASVGPARDPDIAPSAEELPAPRPTAGELFALYVTPQL
                     IGTGVGRALMAAGTDRARAKGFRALYLWVVRGNTRARRFYERAGFVPDGAEEAYEVGGR
                     SVPEVRYWRPLTARTP"
     misc_feature    13466..13478
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.45"
                     /tool="antismash"
     gene            13505..14326
                     /locus_tag="STRMOE7_RS31145"
                     /old_locus_tag="STRMOE7_31140"
     CDS             13505..14326
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (19-187). E-value: 8.5e-13.
                     Score: 40.5. Matches aSDomain:
                     nrpspksdomains_STRMOE7_RS31145_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018537470.1"
                     /locus_tag="STRMOE7_RS31145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_31140"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_084775025.1"
                     /sec_met_domain="adh_short (E-value: 5.1e-31, bitscore:
                     106.8, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 3.9e-29, bitscore:
                     101.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERTTQTGPDVPGTGSDRRVVLVTGAGTGIGRATAHAFAAEGARV
                     VAVGRRAEPLAETAAGAAEGAAAQDGSGGGGITPYVADITADGAPEAVVRHAVERYGRL
                     DVLVNNAAVVGNGAFGSYTREGMAPQLATNLVAPVLLTQEALPHLERTGGVVVNVSTSV
                     GQRGWPGNAVYAATKTALELLTRSWAVELAPRGVRVVAVAPGAIETPIALHQGWSPEQR
                     EALRKWQIAHTPMGRVGRPEEVAWAVTRLAAPAASFVTGVVLPVDGGAVVG"
     CDS_motif       13562..13657
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_STRMOE7_RS31145_0001"
                     /evalue="1.30E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="STRMOE7_RS31145"
                     /protein_end="51"
                     /protein_start="19"
                     /score="17.8"
                     /tool="antismash"
                     /translation="VVLVTGAGTGIGRATAHAFAAEGARVVAVGRR"
     aSDomain        13562..14065
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STRMOE7_RS31145_PKS_KR.1"
                     /evalue="8.50E-13"
                     /label="STRMOE7_RS31145_PKS_KR.1"
                     /locus_tag="STRMOE7_RS31145"
                     /protein_end="187"
                     /protein_start="19"
                     /score="40.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVLVTGAGTGIGRATAHAFAAEGARVVAVGRRAEPLAETAAGAAE
                     GAAAQDGSGGGGITPYVADITADGAPEAVVRHAVERYGRLDVLVNNAAVVGNGAFGSYT
                     REGMAPQLATNLVAPVLLTQEALPHLERTGGVVVNVSTSVGQRGWPGNAVYAATKTALE
                     LLTRS"
     CDS_motif       14054..14107
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_STRMOE7_RS31145_0002"
                     /evalue="3.00E+00"
                     /label="PKSI-KR_m1"
                     /locus_tag="STRMOE7_RS31145"
                     /protein_end="201"
                     /protein_start="183"
                     /score="0.7"
                     /tool="antismash"
                     /translation="LTRSWAVELAPRGVRVVA"
     gene            14394..14750
                     /locus_tag="STRMOE7_RS31150"
                     /old_locus_tag="STRMOE7_31145"
     CDS             14394..14750
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090474.1"
                     /locus_tag="STRMOE7_RS31150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_31145"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_084775026.1"
                     /transl_table=11
                     /translation="MRIGELARITGASPRALRHYEREGLIASERAANGYRVYDARTAVR
                     VRNIRHLLTAGLTLADVRCFLACLDGDMTTAPPSAEGLRIARERLAALDERIAAQTEAR
                     DRLARALDGVVPAG"
     gene            complement(14816..15846)
                     /locus_tag="STRMOE7_RS31155"
                     /old_locus_tag="STRMOE7_31150"
                     /pseudo=""
     CDS             complement(14816..15846)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602145.1"
                     /locus_tag="STRMOE7_RS31155"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_31150"
                     /product="Rv2578c family radical SAM protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRWENLGESPSALFGTDVVSRTIDTPEFRGITFHEVRARSIVNRV
                     PGASRMPFEWTVNPYRGCSHACVYCFARKTHSYLDLDTGLGFDSQIVVKVNAPELLRRE
                     LTGRRWRGDHIAMGTNVDCYQRAEGRYRLMPGILAALRDHANPFSILTKGTLILRDLEL
                     LRQAAAVTDIGISVSVGFLDRELWRTVEPGTPAPDRRLDVVRTLTAHGIPCGVLMAPVI
                     PFLGDSPEQLRATVRAVAEAGAGSVTPLVLHLRPGAREWFMAWLGHHHPQLVRRYEAMY
                     ADGAYAPKWYQRRITRQVHELATEYGIGPTRPGAARRIPPPRPPRPAERPKPRRNPPS"
     misc_feature    15879..15895
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 22.09"
                     /tool="antismash"
     misc_feature    15889..15902
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.23"
                     /tool="antismash"
     gene            16003..16446
                     /locus_tag="STRMOE7_RS31160"
                     /old_locus_tag="STRMOE7_31155"
     CDS             16003..16446
                     /NRPS_PKS="Domain: Polyketide_cyc2 (3-146). E-value:
                     4.7e-24. Score: 77.3. Matches aSDomain:
                     nrpspksdomains_STRMOE7_RS31160_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010038765.1"
                     /locus_tag="STRMOE7_RS31160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_31155"
                     /product="SRPBCC family protein"
                     /protein_id="WP_084775027.1"
                     /transl_table=11
                     /translation="MGQVEATTQREIAADPEDVFDALADYAGTRRQLLPEHFSEYEVRE
                     GGDGKGTLVHWKLQATSKRVRDCLLEVDEPTDGQLVEKDRNSSMVTTWVVTPAGEKRAR
                     VVVTTTWQGAGGIGGFFEKTFAPKGLGRIYDALLDKLAAHMEK"
     aSDomain        16012..16440
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STRMOE7_RS31160_Polyketide_cyc2.
                     1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="4.70E-24"
                     /label="STRMOE7_RS31160_Polyketide_cyc2.1"
                     /locus_tag="STRMOE7_RS31160"
                     /protein_end="146"
                     /protein_start="3"
                     /score="77.3"
                     /tool="antismash"
                     /translation="VEATTQREIAADPEDVFDALADYAGTRRQLLPEHFSEYEVREGGD
                     GKGTLVHWKLQATSKRVRDCLLEVDEPTDGQLVEKDRNSSMVTTWVVTPAGEKRARVVV
                     TTTWQGAGGIGGFFEKTFAPKGLGRIYDALLDKLAAHME"
     gene            16699..19215
                     /locus_tag="STRMOE7_RS31165"
                     /old_locus_tag="STRMOE7_31160"
     CDS             16699..19215
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019071307.1"
                     /locus_tag="STRMOE7_RS31165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_31160"
                     /product="MFS transporter"
                     /protein_id="WP_084775028.1"
                     /transl_table=11
                     /translation="MGGTTLSARDGRSGPPAPGATTAPAAATRAAGPGGGAPVAIGPRR
                     FRAVFLGLMLTLLLAALDQTVVATALPKIVGELHGLGTMSWAVTSYLLASTLGLPLYGK
                     LGDLFGRKPVFLFAILVFTAGSALTGWSRTMHELVLFRAVQGAGGGGLMIGVQAIIADL
                     VPPRARGRYLGLIGAAFGIASVAGPLIGGFCTDHVSWRWCFYLNVPFGALTLLLIAFVL
                     KLPRPAGRPKLDIAGALLLAAFSTCLVLLTSWGGTEYAWNSRVILGLGAGALGTALLFL
                     AVEYFASEPIVPLRLFRDSVFNITGLIGAAVGLALFGAASYLPTFLQMVDGASATASGL
                     LMLPMMGGIVLASVVSGRLISRTGHYKVFPLLGCAAAAVGMWLLTRLRQDTPREEYSLW
                     MGILGLGIGCVLPVLVLAVQNSVRRSDLGTATSATHYFRQIGGSVGAALFGTLLADRLA
                     RRLDDRLPASTRLPDPESITPQLVRALPASLRDSYVAAYAHAMPGIFFYLVPVLVLGFV
                     LAVFLKEKPLVSHTSHAPQAAPTPHPPYGDGADTAAVPQARPPADQPQGNSRGSASSYR
                     KAHAYAAAGHSGVPVCGTVQHHDGSIVPRAALTLIDVAGRQIGRGATGEDGRYALSTPG
                     TGSYVLIAAAGGHQPQAVSVTVGERPVELDVVLGGAGRLAGTVTTADGTPVRDAMVTLT
                     DVRGEVVATTRSGREGGYVIGELVAGEYTLASSAPAFRPAALPVTVQASRETRQDIELA
                     GGAVLRGTVRAGGGRPVEDARVTLLDAAGNVVDTATTAADGLFRFVDLSAGEYTVIAAG
                     YPPVATVLQVAGGGRTERDLQLGHED"
     gene            19313..20170
                     /locus_tag="STRMOE7_RS31170"
                     /old_locus_tag="STRMOE7_31165"
     CDS             19313..20170
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (21-267). E-value:
                     6.2e-25. Score: 80.1. Matches aSDomain:
                     nrpspksdomains_STRMOE7_RS31170_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018538253.1"
                     /locus_tag="STRMOE7_RS31170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_31165"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_084775029.1"
                     /sec_met_domain="PF00561 (E-value: 4.6e-19, bitscore: 67.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.2e-12, bitscore:
                     47.6, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTFTAPDGTALAYHLVGEGEPLLCLPGGPMRASAYLGDLGGLSR
                     YRRLVRLDLRGTGDSGVPADPATYRCDRQVDDVEALREHLGLSRVDILAHSAAGDLALL
                     HAARHPHRVRSLTLVASRARALGIDFTVEHRHEAADLRAGEPWFPGARAAFDALWTGSA
                     TDADWDAAMPFFYGRWDAAARAHAADELAQTNEPAAERYAAAGAFDPATARAALARLDA
                     PVLVLAGAWDGGPLPRVAATVAEAFPRAELTVQPGAGHYPWLDDPAGFSATVAAFLDAA
                     GTEG"
     aSDomain        19376..20113
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STRMOE7_RS31170_Abhydrolase_1.1"
                     /evalue="6.20E-25"
                     /label="STRMOE7_RS31170_Abhydrolase_1.1"
                     /locus_tag="STRMOE7_RS31170"
                     /protein_end="267"
                     /protein_start="21"
                     /score="80.1"
                     /tool="antismash"
                     /translation="PLLCLPGGPMRASAYLGDLGGLSRYRRLVRLDLRGTGDSGVPADP
                     ATYRCDRQVDDVEALREHLGLSRVDILAHSAAGDLALLHAARHPHRVRSLTLVASRARA
                     LGIDFTVEHRHEAADLRAGEPWFPGARAAFDALWTGSATDADWDAAMPFFYGRWDAAAR
                     AHAADELAQTNEPAAERYAAAGAFDPATARAALARLDAPVLVLAGAWDGGPLPRVAATV
                     AEAFPRAELTVQPGAGHYPWLDDP"
     misc_feature    complement(20236..20251)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.05"
                     /tool="antismash"
     misc_feature    20945..20960
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.92"
                     /tool="antismash"
ORIGIN
        1 tccaggttgg cgatggcctt tccggagacg tccggcaccg acatgcccag cagcagcgaa
       61 tagatgtagt tgccgaccac gacgttcttg ccgaagtcgg tggtctgctc cgcgtagttg
      121 ctgtccatgt gcagcgggtg gtgattcatc gtgagcaggc agaagaggtg gtcgtcgtat
      181 tcggtgacgg tcttccccgg ccagtgcttg tacacatcgc cgacggtgaa ttcctcatag
      241 gtacggccga actgcatcgc gctcacgcct ccggggcttc gaacttggat gtacggatca
      301 tgcctgcggc ccggcccttg ccggagacga cgagcgccat tttccggctc gcctcgtcga
      361 tcatctcgtc gccgagcatc gccgacccct tcttgccgcc cgcctccgag gtgtgccact
      421 cgtaggcgtc caggatcagc tcggcgtggt cgtagtcctc ctgggagggc gagaacacct
      481 cgttggcggc atcgacctga cccggatgca gtacccactt gccgtcgaag ccgagggctg
      541 cggcccggcc ggccacctcg cgatagccgt caatgttctt aatctgaagg tacgggccgt
      601 cgatggcctg caaatcgtag gtccgtgccg ccatcagaat gcgcatcaga atgtagtgat
      661 aggcatcggc gccatagccg ggcggttgct ccccgaccac cagggacttc atgttgatcg
      721 acgccatgaa gtccgccggg ccgaagatga tggtctccag gcgcggcgag gcaccggcga
      781 tcgcgtcgac gttcaccagg cccttggcgt tctcgatctg cgcctcgatg ccgatccggc
      841 cgacctcgaa gcccatcgtc ttctcgatct gggtcagcag caggtccagc gccacgatct
      901 gctgggcgtc ctggaccttg ggcagcatga tgcagtcgag gttgggcccc gcgccctcga
      961 cgaccgtgat gacgtcccgg tacgtccagt gcgtcgtcca gtcgttgacc cgcacgaccc
     1021 gggtcttgcc ggtccagtcg ccgccgttca gcgcctcgac gatggagtgc cgggcgccct
     1081 ccttggcgag cggggcgcag gcgtcctcca ggtccaggaa gacctggtcc gccgggaggc
     1141 cctgggcctt ctccaggaaa cgcggattgc tgccggggac cgcgagacag gagcgacggg
     1201 gccgcaggcg attgccgggg gctgtcatgc ggggacctcc agggggtcga gctggttggc
     1261 tttccggatc tcgtcgacga tacggccgat gatctccgtg ataccgaagt ccttgggggt
     1321 gaagacggcc gccactccgg cttcccggag cgcggtggcg tcggcggagg ggatgatgcc
     1381 gccgacgatg acgggtatag gggcatctcc cgggccgtca ggcccagggg aagcgtccac
     1441 gccggtgcgg cgcagccggt ccaggacgtc cggtaccagc tcggcgtgcg agccggacag
     1501 gatggacagg cccacgcagt gcacgtcctc ggcgaccgcc gccgagacga tctgctccgg
     1561 ggtgagccgg atgccctggt agatcacctc gaagccggcg tccctggccc gtaccgcgat
     1621 ctgctcggcg ccgttgctgt gaccgtccag gccgggcttg ccgaccagca gccgcagctt
     1681 gccggtgccg agttcggccg ccgtcttggc gaccttctcg cggaccgcgg ccagcgggct
     1741 gcccgcctcg gcggcgaccg ccaggggagc gctggagaca ccggtgggtg cccggaactc
     1801 gccgaagacg tcccgcagcg cccaggacca ctcaccggtc gtgacgccgg cgcgggcgca
     1861 ctccagggtc gccgcgaaga ggttggcgtc gcccgccgcg gtcttcttca gtaccgacag
     1921 cgcctcctgg gcgcgcgtct cgtcgcggtt gtcccgccac tcgtgcagcg cctgcaccac
     1981 gcgcgcctcg ttggccgggt cgacggtcat gatggccgtg tcgaggtccg cggtgagcgg
     2041 gttgggctcg gtgccctcga agcagttgac gccgacgatc ttctcctcgc cggcctcgat
     2101 ccgggcccgc cgctcggcgt gcgcggaaac cagctgcgac ttgaggtagc cggactccac
     2161 cgcggccatc gcgccgccca tctcctggat ccgctcgatc tccgcgaggc agtcggtgac
     2221 cagggcgtcc accttggcct cgatgacgtg cgagccggcg aagatgtcct cgtactccag
     2281 caggtcgctc tcgtgcgcca ggacctgctg gatgcgcagc gaccactgct ggtcccaggg
     2341 gcggggcagc cccagcgcct cgttccaggc cgggagctgg acggcgcggg cgcgggcgtc
     2401 cttggagagc gtcacggcca gcatctccag cacgatgcgc tggacgttgt tctccggctg
     2461 cgcctcggtc agcccgaggg agttgacctg gacgccgtag cggaagcggc gctgcttctc
     2521 gttctcgatg ccgtagcgct cgcgggtgat cttgtcccag atgcggccga aggcgcgcat
     2581 cttgcacatc tcctcgacga accggacgcc cgcgttcacg aagaacgaga tgcgggccac
     2641 gacgtcgccg aacttctccg gcggtacctg gccggagtcg cgcaccgcgt ccagcaccgc
     2701 gatggcggtg gacatggcgt aggcgatctc ctgcaccggc gtggccccgg cctcctgcag
     2761 gtggtagctg cagatgttga tcgggttcca cttggggagg tgcgccaccg tgtacgtgat
     2821 catgtcggtg gtcagccgca gcgacggccc gggcgggaag acgtgcgtcc cgcgcgagag
     2881 gtattccttg acgatgtcgt tctgcgtggt gcccgacagc ttgctgatgt cggcaccctg
     2941 ttcctcggcg accacctcgt acagcgccag cagccacatg gccgtcgcgt tgatggtcat
     3001 ggaggtgttc atctggtcca ggggtatgtc ctggaacagc cggcgcatgt cgccgaggtg
     3061 ggacaccggg accccgaccc ggccgacctc accgcgggcg aggatgtggt cggggtcgta
     3121 accggtctgc gtcggaaggt cgaacgcgac cgacagaccg gtctggccct tggcgaggtt
     3181 gcgccggtac agctcattgg acgcctcggc ggtggagtgc ccggcgtagg tccgcatcag
     3241 ccacggacga tccttctgac gctcagtcat atcaggcccg tatcttcggg gttcaggaaa
     3301 gcccgagagg ctcagacgtt ccggaaccgg ttgatggcgt cgaggtgctt ggcgcgcatt
     3361 tcctcatcgc gcactcccat gccctcctcg gggccagcgc cagcacgccg accttgccct
     3421 ggtggaggtt gcggtgcacg tcgtacgccg cctggccggt ctcctcaagg gtgtacgtct
     3481 tcgacagggt ggggtggatc ttgcccttgg cgatcagacg gttggcctcc cacgcctcgc
     3541 ggtagttggc gaagtgcgag ccgatgatcc gcttcagcga catccacagg tagcggttgt
     3601 cgtactcgtg catgtagccc gaggtcgagg cgcaggtggt gatggtgccg cccttgcggg
     3661 tgacgtagac gctcgcgccg aaggtctcgc ggccggggtg ctcgaagacg atgtcgatgt
     3721 cctcgccgcc ggtgaattcg cggatgcgct tgccgaagcg cttccactcc ttcgggtcct
     3781 gggtgcgctc gtccttccag aacttgtagc cctcggcgtt gcggtcgatg atcgcctcgg
     3841 cgcccatctt ccggcagatc tccgccttct ggtcgctgga gaccacgcag atcgggttgg
     3901 cgccgccggc cagcgcgaac tgggtggcgt agctgccgag tccaccgctc gcgccccaga
     3961 tcaggacgtt gtcgccctgc ttcatgccgg cgccgttgcg ggagaccagc tggcggtacg
     4021 cggtggagtt caccagaccc ggcgccgccg cctcctccca gctcaggtgc ttgggcttgg
     4081 gcatcagctg gttggacttg accagggcga tctcggccag gccgccgaag ttggtctcga
     4141 agccccagat gcgctgctcg gggtcgagca tggtgtcgtt gtggccgtcg gaggactcca
     4201 gctcgacgga caggcagtgc gcgacgacct cgtcgccggg gccccaggcg ttgacgccgg
     4261 ggccggtgcg cagcacgacg ccggccaggt cggagccgat gacgtggtac ggcaggtcat
     4321 ggcgcttggt gagcggggag agcttgccgt agcgctccag gaacccgaac gtcgagagcg
     4381 gctcgaagat cgaggtccac acggagttgt agttcacgga ggaggccatc acggccacca
     4441 gcgcctcacc ggggccgagc tcgggcaccg gcacgtcctc gacgtgcagc gacttacggg
     4501 ggtccttctc cttcgtgggc aggccggcga acatctcggc ctcgtccttg tgcacggtca
     4561 ccgcgcggta ggactcgggg aggggcagcg cggcgaagtc tgcgctggtg gcgtcggggg
     4621 agaggattgc gtccaggatc ttgttcactg ggtgcctccg gcgttgaggt ctcccctgct
     4681 cgaacggagt tgagagcttg gggaatcgtc tgggaaacgg cttgagggaa cgtcgggggt
     4741 ggagcgggag gtggtgccgt cggttcggcc ggggtggcgc cgcttccgtc gcctctgcgg
     4801 tggtcgcaga gccgtcggcc gcggtgcctg gcagcgctgt ggtgagcgcg gagcccagcg
     4861 gctgctgggg gtgcctgtga cgcaggcgtc cgggcggcca gccgcgtagg gctggtggga
     4921 cagccggcgc gcgatggttc actgcacgcc ggccgcccgg acaccctcaa cgtatgacac
     4981 cgcgtgccag tcgacaagac actgagtgcc aagaatttct ctcagatgtc atccgggggg
     5041 cacgcatgag caacagatgc cccgatcgga ggcatggtcg tcacgcaaag aaatcccgtc
     5101 cctacgcatc gtacgcaggg acgggattag gccgttcggg tcgcggcccg gtcggtaccc
     5161 gggctccggg ccgcgacggt gtgcggtggt ggaggttccg ccgctacttc cgttccttga
     5221 tggccttgcg gatggtgcgc atgacctcct ccagcggggc gtccgtgcgg gccaccgcga
     5281 ccagcacctc gccctccctg gagacggctg ccgcgggctg ctcccccgtg gtggtgcggc
     5341 ccgcgccgat gccggcgccg aaggtctccc ggacgatctc gaaggcgtgg tccagctgcg
     5401 cctcgacatc gccctccgcg ccggcccgca gccagcggcg caggacgtgg ttgtgcgcgg
     5461 tgaccacggc ggacgcggcg acctcggcga gcagcgggtc gtcgtcgccc tcgcggtgcg
     5521 cgccctcgtc gaagtggccc agcagatagc gggtgaacag tcgctcgtaa cgggccaccg
     5581 aggcgatctc ggcctcgcgg agggtgggta cctcgcgggt gaggcggtaa cgggccaccg
     5641 cgacggccgg ggaggccgcg tacatccgca tgacctcctt gatgccgcgg cagaccgtgt
     5701 cgagcgggtt ctcgtgcggc ggggcggcgt ccaggacggc ctcggcccgt acgagggtgt
     5761 cgtcgtggtc ggggaagatc gcctcttcct tggagcggaa gtggcggaag aaggtccgcc
     5821 gggcgacgcc cgcggcggcc gcgatctcat cgaccgtcgt cccctcgtag cccttggtcg
     5881 cgaacagctc catggccgcc gccgacaatt cgcggcgcat cttgagccgt tgtgcggccg
     5941 cgcggcgggt gccgggagaa gtggcgtcgg gggtgtcgga gggctgcgta cgagcgggct
     6001 gggacatgtg gggacggtac tgcatattta cgcggcctgc ggcatgaggt gccgcctccg
     6061 cccttgtgag cgggggtgga ccgccgtcgg gttccagcag tccaccccag cctccccctg
     6121 ccgggcggga gcggcgccac gggtcagcgc cgggcgtact cacggaagcc gcggccggtc
     6181 ttgcggccga ggcagccggc cgcgacgagg tgctccagca gcggtgccgg ggcgagcccg
     6241 gggtcgcgga actcggcgtg cagcaccttc tcgatggcca gggacacgtc caggccgacc
     6301 acgtcgagga gttcgaacgg gcccatcggg taaccgccgc cgagcttcat ggcggcgtcg
     6361 atgtcgtcca gggtcgcgta gtgctgctcg accatcttga tcgcgttgtt gaggtaaggg
     6421 aacagcagcg cgttcacgat gaatccggcc cggtcgccgc agtccaccgg gtgcttgcgg
     6481 accttggcgc agaccgcccg cacagtggcg tgcacgtcgt cggccgtcag gaccgtacgc
     6541 accacctcga ccagcttcat ggcgggcgcc gggttgaaga agtgcatgcc gatgacgtcc
     6601 tgcgggcgcg aggtggcgcg ggcgcaggcg acgacgggca gcgacgaggt cgtggtggcc
     6661 aggacggcgc cgggcttgca gaccttgtcc agcgtccgga acagctcctg cttgaccgcg
     6721 aggtcctcgg ccaccgcctc gacggccagg tccacgtccc cgaaggcgtc gagcgacccg
     6781 gccggggtga tcgcggccag cgcggcgtcc cgggcctcgg cggtcatccg gcccttgtcc
     6841 accgagcgcc ccagcgactt ggcgatccgg gccttggccg tctccgcctt ctccggactg
     6901 cgggcggcca gcacgacctt gaagcccgcc ttggcgaaca cctcggcgat gccgctcgcc
     6961 atcgtgccgg acccggcgac gccgacggag gagaccgtac ggccggtgcc gagcgcgtcg
     7021 gcggccgccg ggctctccgc gtccgggacc accgtgccgc tgccgggggc ctcgtaggtg
     7081 tagaagccgc ggccggcctt gcggccggtc agccctgcct cggccagctg ccccaggatc
     7141 ggcgcggggg cgtgcagccg gtcctgggag tcggcgtaca tcgcctccag gaccgtacgg
     7201 gcggtgtcca cgccgatcag gtcgagcagc gccagcgggc ccatgggcag accgcagccg
     7261 agccgcatcg cggcgtcgat gtcctcccgg gtcgcgtacc tcgactcgta catcgccgcg
     7321 gcctggttga ggtagccgaa gagcaggccg tcggcgacga atccgggccg gtcgccgacc
     7381 gcgatcgggt ccttgcccag gtcgcgggcg agctgggtga cggccgcgac cgcggtcggc
     7441 gcggtgagga ccgaggagac cacctcgacc agcttcatgg ccggcgcggg gttgaagaag
     7501 tgcacgccga gcacccgctc ggggcgctgc gagtcggccg cgagccgggt cacggagagg
     7561 gcgttggtgc cggtggcgag gatggtgtcc gggcgcacca cggcgtccag ttcggcgaag
     7621 acctggcgct tgaggtcgta gtcctcgggc accacctcga tgacgaggtc ggcgtccgcg
     7681 gcggcctgca ggtcggtgaa ggtgcggaag cgggccaggg cgtcctggcg ctcgcgctcg
     7741 gtgatccgct cccgccgcac cgcatgggcg gtggcggctt cgagggcggc gacggcatgg
     7801 cgggccgcgg tggcgtcggt gtcgatgccg atgacctcgc ggccggcccg ggtcaggacc
     7861 tcggcgatgc cggtgcccat ggtgccgaga ccgacgacgg ccacggtggc caggggcaag
     7921 ggggcggctt cggttggcag atcaggggtg gagtgagggc ccatcgcgag actcctgagg
     7981 gtgttcccct gaaggcaggg gagaagtgac gactgagggt gtccgcgcgg acgcctggcc
     8041 agggaaaagg cgcggcggcc gagccgcggc aaaagccgct ggcagccgca gcgctgctgg
     8101 cagcgccggc gggagcggag ctgcggcggg ccctgtcccg gggccgtgcc gtcgtctccg
     8161 taggtgtgtc gtgctgtgcc gaaccgactt cactctgtgg cggctgcgtc accaggccgc
     8221 ccgagcaggg gtgctgctcg tcccagcagg ttaaccggtg ggtaaccaga gcgccagggg
     8281 tagtcggggt cattaggctg tggtgcaggc cacgtcgcag ggaccggggt ggcccggcgg
     8341 gagggaagcg gcaaatggaa gacgaattcc acgagttgac ggaccgggtg cgggccgaac
     8401 tccgctcccc acaggatctg gtcgcctacg agcggttact ggggctggcc cgcaagaaca
     8461 cccccgcggg gcgggaggaa ctggcccgga tgctggtcgc cgtggaacgc cccctgtggg
     8521 ccagggagat cgccgccttc atcctcggct gcgccggcga caagcgcgcc ttcgagacgc
     8581 tcgtcctgct gctgaactac cgcgacccgg tgcgctgcgc gaccgccgcg cacgcgctga
     8641 gccggctcgg cgacccacgg accgcccgtg cggcggccgc gctcgccacc aacccgctgc
     8701 gcaccgccta cgccctgcat ccggtccggc tgctcgccga gctgcgcgcg ccccagtccg
     8761 taccggcgct gatcgcgacg ctggagcggc tgctgacccc gcacaacccc tactggcggg
     8821 tggcgctcgc ctgcgtggag ggcctgggcg cgctgggtga ccggcgggcc gtcccggtgc
     8881 tcacggccgc tgtcgcccac ccccggctgg cggccgccgc ggcggcatcg ctggcgcggc
     8941 tgggggtgca cgaggtgccg gcgcagcgcg gcgggaccaa ggggacggag ccgtccgggg
     9001 ccgctggggc acccggggcc ccgggacagc ggagcgggag acctgagagc gtcgccgggg
     9061 ccgcgccgac acgcggcgcg gccccggcgt cctcacaccc ggtcggcggc gatcagcagg
     9121 tactggaagc tgccgttgcg gtaggcgttc aggaaggtgt cctcgatgcc cgtgaccaga
     9181 tggtcggcct cccggcgcag ctcccagtac ggcagcgcgg cctccgtcag gtcctcgacg
     9241 tgtacgggca cgagccggtt gcgggccatc gcgctgaagt acgccgagcg gggatggatg
     9301 tcgcagatgt agtgggcgtt gatcagggac acctcgcggg aggcgcgccc gtaggcgtcg
     9361 ttgtagcagc cggtgattac cacatagcgt cccccgcgcc gcagcagccg tgcgtgctcg
     9421 gcgaagagca ggtccagctc gacgtacatg gacgactcgt tgttccagga cgccgcgtac
     9481 gcgccggagg tgaaaccggt gtcgagcatg ttgcggtggt ggtagcgcac cttgtcgtcg
     9541 atgccgcgct tgcgggcctg ctcgttggcg aagtcggcct gcttggcgga gatggtggcc
     9601 ccgtcggtgg agcagccgta gcgctggtgc gcgaccacgc tgccgccgcc gcgtccgcac
     9661 ccggcgtcga agacgcggtc ggcggcggag acgtcaccga ggtgggaggc gaggagctcg
     9721 gcctgggcgt gctccagacg gtgcagttcg gcggtgaccc gctcgcggcg ccggtcagga
     9781 tccggttcgt cgagcaccga ccggtcggcg tccccgatgc cgtagtggtg gtggtagagg
     9841 tcgtcgatct tcccgagttc gaggttgacc gggttttcct cggcgttcca gtagtccgcg
     9901 acgcgggact ggtacgtgga ctgggtcggc accggtgtgc gggcggtgcc ggcgggagcg
     9961 atggtcaacg gtgactcctt gctgtggtgc gcggtgctgt ctaccagtag ttcggaagct
    10021 ggtagcggtc ggtgttggtg gcgtgccact cgtggttgcc ggagacccag tcggccaggc
    10081 cctggaggta ccgttcgatg acgggggagg tggcggccag cagggccgac tccgtctcga
    10141 acgcctccat gatctggttg tggatctcga cgctcttcaa gtacgcggcc ttcaggccgc
    10201 gttggtcgtt ggcggcaacc acttggggca ggttcaggtg gtccggatcg ctcgccagct
    10261 ccctcgtgaa cgagtacagg tcgttgacga tggtcgtggc gttgcaggcc agcgcggtga
    10321 cccgctggat ctcgggacgg gcgtagagcg cctcgggaag ctcgtagccg tcgatggcgt
    10381 cgacgatgga caggcacggg cggaagttgt tgaactgccg catcaccagg tactcccaga
    10441 ccttgggtgc gtgccgcgtc tccgcccagg cggcctcggc gaggtagccg aggtgcagcc
    10501 gggcgatgtc gtggacgaac cggtcggtct ggctgggggt ggcgagggcc gcgtagtcct
    10561 tgagggccac gtggtacgag cgcagcggtc cgtcggcctg cacgccgcgg cgccactcct
    10621 cctcgtgttc gggggtgccg tgatacgggt cgagggccga ctgcgccatg atcagccggc
    10681 cgccgaggcc gcggtgcgcg ccgcccctgc cctcgtcctc ctcgcagtag cagttgtcga
    10741 cgatgttctc cgccagcagc aacttgcccg cgacggtgag gcgttcgagg tcggccgcac
    10801 cggggtgctg gaggacgacg gcccggccga actggaactc tgcgaagtcc ccgctccact
    10861 ccgaggggaa cagatccagc tcgcgggccc aggtctccag cctgcggtcg atctcctcga
    10921 ccttttccgg gttggcgggc gcggcgggcc ggtacctcag cccggggacg gcgccgccgg
    10981 gacgggtccg tggggtgcgg gtgagtttgg gcgggccggg cagcgtgaat gcggccgtgg
    11041 tcttcggagg cgtgctcatg gttcgggact ccacccggtc agtcggcgtt ccggccgatc
    11101 tggacgttct ccaggacccc ggccgcgtcg ggcacgagga tggccagcga gtagtaggcg
    11161 gtgacgaggt acttgatgac ggcggcctgg tcgatgccca tgaaccggac gttgaggccg
    11221 ggctggaact cctcggggag gccggtctgg tacaggccga cgacgccctg gtccgcctca
    11281 ccggtgcgca gcgcgatgat gctgctggtg tgcgactcgc tgatcgggat cttgccgcac
    11341 gggaagatcg ggacgccgcg ccaggcgggg acctcgtgcc cgtcgacgtt cgcggtgccc
    11401 ggcaccagac cgcgtttgtt gcactgccgg aagaaggcgg cgatcgcctt cgggtgggcc
    11461 aggaacagcc gggtcttgcg gcgcatggac aacagctcgt ccatgtcgtc gggggtgggc
    11521 gggccggtgt aggtgctgat ccgctgcccg tagtcggcgt tgtgcagcag cccgaactcc
    11581 cggttgttga ccagttccca ttcctggcgc tcgcggatct cctccacggt gagccggagt
    11641 tgctgctggg tctggtccat cggttcgttg tagaggtcgg cgacccggct gtgcacccgc
    11701 agcacggtct gggtcaggga gagttcgtac tcgcgcgggg cgaggtcgta gtcgacgaag
    11761 ccgccggaca gcctgggctc gccgacatgg cccgcctgta ccggaacctc cgcctcgccc
    11821 ttgcggttca tggggagctg ctgccgctcc gcgtacgccg tcagatgggc ggccagggac
    11881 ggcacccggt cggtgaactc ccggagcacg tcccagggca gcaccatcag gacgccggcc
    11941 gtctcggccc gtaccgagct ccgccaccgc gggtcgggcc ggccgagcgc ctcgtccccc
    12001 atctggtcgc cgtccgtgac gacgccgatg atctcctcct cgccgtactt gccggccgtg
    12061 tagcgggcga aacggccgtg cacgacgagg tacgcctcgg tggcgggttg gccggcctcg
    12121 aagaggacct ggccggcccg gacctcccgg gcccggaagc ggccggcgag ctccttgagg
    12181 acctcaccgt cgtcgtatcc gcgcagcgcg ggcagctcgg tgagcgtccg cgggatcacc
    12241 ctgatgtcgt ccgcaccgtt ctgctcgaac tcgacgcggc cccggccgac gcggagttgc
    12301 agacgccggt tgacccggta ggtgccgccc ttgacgtcca cccacggaag cgacttcagc
    12361 agccaccgcg aggtgatggc ctgcatctgg ggctcggact tggtggtggt cgccagctgg
    12421 cgcgcggcct gtgtgccgag gctggtgggc gcaccgtccg cggatggttc gagagcgggc
    12481 tcgtcggtgg cggaaccggt gacactgtcc ggtacggaca ctttccctcc cgggagctga
    12541 acagaagtga gcagaacggc cggtggggga caaggtggcc gtgcgcagga gcaagccaaa
    12601 caggagggag tgcacgctgg taacggcgtg aaagggggcg gactcgcgcc cgggagtcat
    12661 aaacgtcaga aggaggcaaa ccggcgcgcg ctgcgttcgc cgcacgccgt ccgatcatgg
    12721 ccttcggggg cggctgctcc cgcgccccct gccggtgtcc accgcggcta cggcgtcctc
    12781 gccgtgagcg ggcgccagta gcgcacttcg gggacgctgc ggccgcccac ctcgtacgcc
    12841 tcctccgccc cgtccggaac gaagccggcc cgctcgtaga accgccgggc acgggtgttg
    12901 ccgcgtacca cccacaggta gagggcgcgg aaccccttcg cccgggcgcg gtccgtgccg
    12961 gcggccatca gggcgcgtcc gacgccggtg ccgatcagct ggggcgtcac gtacagggcg
    13021 aacagctcac cggcggtcgg ccggggcgcg ggcaactcct cggcgcttgg ggcgatgtcg
    13081 gggtcgcggg ccgggccgac cgacgcccag ccgaccactt cgccggccgc ctccgccacc
    13141 aggtcggcca cgtccggtgg ccggcgcgcg aaccacgacc gccgccgctc ggcgtccgcc
    13201 gtcacgctca tggcgtccag atacgcctgc ggcatcagcc cgcggtaggc cgcctgccag
    13261 ccgcgcaccc ggaccgccga gaccccggcg acatcggcct cggtcatttc ccgtatccgc
    13321 acgcggtgcg gcggctgccg gtgcccggaa cgtgtgctgc ccgtggaact gtccatgccg
    13381 gagagggtag gggcccggtc aagcggacga ccggacagcg gccgtcgccc ccgaagggcc
    13441 cggccgccgc cgggagaggt gccgcttgac cttgtcacag gcgtcagggt tcgagacttc
    13501 cggcatggaa cgcaccacgc agaccgggcc ggacgtgccc ggaacgggat cggatcgcag
    13561 ggtcgtgctc gtcaccgggg ccggtacggg catcggacgg gccacggcgc acgccttcgc
    13621 ggcggagggg gcccgggtgg tggcggtggg ccgccgggcc gagccgctgg cggagaccgc
    13681 ggcgggggca gccgaggggg cagcggcgca ggacggctcc gggggtggcg ggatcacgcc
    13741 ctacgtcgcc gacatcaccg cggacggggc gcccgaggcc gtcgtccgcc acgcggtgga
    13801 gcggtacggc cggctcgacg tcctggtcaa caacgccgcg gtggtgggca acggcgcgtt
    13861 cggcagctac acccgggagg gcatggcgcc ccaactcgcg acgaacctcg tcgcccctgt
    13921 gctgctcacc caggaggccc tgccccacct ggagcggacc ggcggggtgg tggtcaacgt
    13981 cagcacctcc gtcggccagc ggggctggcc cggcaacgcg gtctacgcgg cgaccaagac
    14041 cgccctcgaa ctcctcaccc gcagctgggc ggtggaactc gcaccgcgcg gcgtccgggt
    14101 cgtcgcggtc gctcccggcg cgatcgagac gccgatcgcg ctgcaccagg gctggtcccc
    14161 ggagcagcgg gaggccctac ggaagtggca gatcgcgcac acgcccatgg gccgggtggg
    14221 ccgccccgaa gaggtggcct gggccgtcac ccggctcgcc gcgcccgcgg cctcgttcgt
    14281 gaccggtgtg gtgctgccgg tcgacggggg agcggtggtg ggctgaacgg gccccgtccg
    14341 ccggccgtcc tgtagaacgg tgcggaaacc ggcggcccac ggaaggagcc ctgatgcgga
    14401 tcggcgagct ggcgcggatc accggtgcgt cgccgcgcgc gctgcgccat tacgagcgcg
    14461 agggactgat cgcctccgag cgggccgcca acggctatcg cgtctacgac gcgcgcacgg
    14521 ccgtacgggt gcgcaacatc cggcatctgc tgacggccgg gctcaccctc gccgacgtcc
    14581 ggtgcttcct cgcgtgcctg gacggcgaca tgaccaccgc gccgccgtcc gccgaggggc
    14641 tgcggatcgc ccgtgagcgg ctcgccgccc tcgacgagcg gatcgccgcc cagacggagg
    14701 cgcgcgaccg tctggcgcgg gccctggacg gggtggtccc cgcggggtga gcgggcggcc
    14761 ccaccgggcc gccgtcaggt tcaggcgtcg ggcgtcaggc gtcaggcgtc aggcgtcaga
    14821 gcagggtcaa ctgggtgggt tccgccgcgg tttcggccgc tcggccggcc gcgggggccg
    14881 gggcggcggg atgcggcggg ccgcgcccgg ccgggtcggc ccgatgccgt actccgtggc
    14941 gagttcgtgg acctggcggg tgatccgccg ctggtaccac ttgggggcgt aggcgccgtc
    15001 cgcgtacatc gcctcgtagc gccgcaccag ctgggggtgg tggtggccca gccacgccat
    15061 gaaccactcc cgggcaccgg gccgcaggtg caggacgagc ggggtgacgg agcccgcgcc
    15121 cgcctccgcg acggcccgga ccgtggcccg cagctgctcc ggggagtcgc cgaggaacgg
    15181 gatcaccggg gccatcagga caccgcacgg gatgccgtgc gcggtgagcg tacgcaccac
    15241 gtccagccgg cggtccggtg ccggggtgcc cggctcgacc gtgcgccaca gctcccggtc
    15301 caggaagccg acggagaccg agatgccgat gtcggtgacc gcggcggcct gccggagcag
    15361 ctccaggtcg cgcaggatca gcgtgccctt ggtgaggatc gagaacgggt tggcgtggtc
    15421 gcgcagcgcc gcgaggatgc cgggcatcag gcggtagcgg ccctcggcgc gctggtagca
    15481 gtcgacgttc gtgcccatcg ctatgtggtc gccgcgccag cggcgcccgg tcagctcgcg
    15541 gcggagcagt tcgggggcgt tgaccttcac cacgatctgg gagtcgaagc ccagcccggt
    15601 gtccaggtcc agatagctgt gcgtcttgcg ggcaaagcag tagacgcagg catgactgca
    15661 cccgcggtag gggttcaccg tccattcgaa cggcatccgg gaggcgcccg gtacgcggtt
    15721 gacgatcgag cgggcgcgta cctcgtggaa ggtgatcccg cggaactcgg gggtgtcgat
    15781 cgtccggctg acgacgtccg tgccgaacag cgcggaggga ctttcgccca gattttccca
    15841 gcgcatcggg cctccttctg gatcctgacg acccccgtcc gtcataatag aacatgtgtt
    15901 cccttgtggt tcgtcaaccc ggattttggg cgtgcccccc agtggtgatt ggcttggcgg
    15961 cgcatcgcag gagcggcagc cgactactgg aggaagacgc acatggggca ggtcgaggcc
    16021 accacgcagc gcgagatcgc ggcggacccg gaggacgtgt tcgacgcgct cgccgactac
    16081 gccggcacgc gccggcagct gctgccggag cacttcagcg agtacgaggt ccgcgagggc
    16141 ggcgacggca agggcaccct cgtccactgg aagctccagg ccaccagcaa gcgggtgcgc
    16201 gactgcctgc tggaggtcga cgagccgacc gacggccagc tcgtcgagaa ggaccgcaac
    16261 tcctccatgg tgaccacctg ggtcgtcacc ccggccggtg agaagcgcgc cagggtcgtc
    16321 gtcaccacga cctggcaggg cgccggcggt atcggcggct tcttcgagaa gaccttcgcg
    16381 ccgaagggcc tcggacggat ctacgacgcg ctcctcgaca agctcgccgc tcacatggag
    16441 aagtgacgcc gcgtcacttc cgtcaccttg ggtgcgtgtc gtcacactca ccggttcggg
    16501 tggtttccgg tgagccgaag tgtgcggccc gccggaacgc atccgtacgg aaagccctga
    16561 tgggagccca atgggcgccc ggggcaaggt acttggcgtc cggtcccgcc cggcagatcc
    16621 cccttcgtcc cgcttgatcg ctgttgtcgc ccgatgcgag taatggggcg gcaacaggcg
    16681 tgacgagggg agcagcacgt gggcgggacc accctgagcg cgcgggacgg ccggtccggc
    16741 ccgcccgcac ccggcgcgac gacggctccg gccgccgcga cgcgggcggc cgggccgggc
    16801 gggggcgcgc cggtggcgat cggcccgcgc cgcttccgcg cggtcttcct cgggctgatg
    16861 ctgacgctgc tgctcgcggc cctcgaccag accgtggtcg ccaccgcgct cccgaagatc
    16921 gtcggcgagc tgcacggcct gggcacgatg tcgtgggcgg tgacctccta cctcctcgcc
    16981 tcgaccctcg gcctgccgct gtacggcaag ctcggcgacc tcttcggccg caagcccgtc
    17041 ttcctcttcg ccatcctcgt cttcaccgcc ggctcggcgc tgaccggctg gtcgcgcacg
    17101 atgcacgagc tggtgctctt ccgggccgtc cagggcgccg gcggcggcgg gctcatgatc
    17161 ggcgtgcagg cgatcatcgc cgacctcgta ccgccccggg cccgcggccg ctacctggga
    17221 ctgatcggcg cggccttcgg tatcgcctcc gtggccgggc cgctgatcgg cggattctgc
    17281 accgaccacg tctcctggcg ctggtgcttc tacctgaacg tcccgttcgg cgcgctgacg
    17341 ctgctgctca tcgccttcgt cctcaagctg ccccggcccg ccggccgccc caaactggac
    17401 atcgccggcg cgctgctgct cgccgccttc tccacctgtc tggtgctgct gaccagttgg
    17461 ggcggcaccg agtacgcctg gaactcgcgc gtcatcctcg ggctcggcgc cggagcgctc
    17521 ggcaccgccc tgctgttcct ggccgtcgag tacttcgcca gcgaaccgat cgtcccgctg
    17581 cggctgttcc gcgactcggt cttcaacatc accggcctga tcggtgccgc cgtcggactc
    17641 gcgctcttcg gcgcggcgag ctacctgccg accttcctgc agatggtcga cggcgcctcc
    17701 gccaccgcgt ccgggctgct gatgctgccc atgatgggcg gcatcgtgct ggcctccgtc
    17761 gtctccggcc gactgatcag ccgcaccggc cactacaagg tcttccccct cctgggctgc
    17821 gcggcggccg cggtggggat gtggctgctg acgcgactcc ggcaggacac cccgcgcgag
    17881 gaatacagcc tctggatggg gatcctcggc ctcggcatcg gctgcgtgct gccggtgctg
    17941 gtgcttgccg tgcagaactc cgtacgccgc tccgacctgg ggaccgcgac cagcgccacc
    18001 cactacttcc ggcagatcgg cggcagcgtc ggcgcggccc tcttcggcac cctcctcgcc
    18061 gaccggctgg cccgccggct cgacgaccgg ctgccggcgt cgacgcggct gcccgatccg
    18121 gagtcgatca ccccgcaact ggtgcgcgcg ctgcccgcct cgctgcgcga cagctatgtc
    18181 gccgcctacg cacacgccat gccggggatc ttcttctacc tcgtgccggt gctcgtcctg
    18241 ggcttcgtgc tcgccgtctt cctgaaagag aaaccgctgg tgtcccacac ctctcatgcc
    18301 ccgcaggccg ccccgacccc gcacccgccg tacggcgacg gggccgacac cgccgccgtg
    18361 ccgcaggccc gcccgcccgc cgaccagccg cagggcaact cccgtggttc cgcgagcagt
    18421 taccgaaagg cccacgccta cgcggcggcc ggtcactccg gcgtccccgt ctgcggcacc
    18481 gtccagcacc acgacggctc gatcgtgccg cgcgccgcac tcaccctgat cgatgtcgcc
    18541 gggcggcaga tcggccgcgg cgccaccggc gaggacgggc ggtacgcgct gagcacgccg
    18601 ggcaccggct cgtacgtgct catcgcggcg gccggcgggc accagccgca ggcggtcagc
    18661 gtcaccgtcg gcgagcggcc ggtcgagctc gacgtggtgc tcggcggcgc cgggcgcctc
    18721 gcgggcaccg tcaccaccgc cgacggcacg cccgtccgcg acgccatggt caccctcacc
    18781 gacgtccgcg gcgaggtcgt cgcgaccacc cgcagcggcc gtgaaggcgg ctatgtgatc
    18841 ggggagttgg tggccggcga gtacaccctc gcctccagcg ccccggcgtt ccggccggcc
    18901 gccctgccgg tcaccgtcca ggcgtcccgg gagacccggc aggacatcga actcgccggc
    18961 ggggcggtgc tgcgcgggac ggtacgggcc ggcggcggac gtccggtcga ggacgcccgg
    19021 gtcaccctgc tggacgccgc cggcaacgtc gtcgacaccg ctaccaccgc cgccgacggg
    19081 ctgttccgct tcgtggacct gtcggccggt gagtacaccg tgatcgccgc cggataccca
    19141 ccggtggcca ccgtcctcca ggtggccggc ggcggccgca ccgaacggga cctgcaactc
    19201 ggtcacgagg actgagcgtc cgcctcccgg cgcggcggcc ggcggcgctc gccgccgtcc
    19261 gtcgcgccgc acgcccttgc caagctcatc gcgcggtgtc gatcatggcg ccatgcccac
    19321 gttcaccgca cccgacggca ccgccctcgc ctatcacctc gtgggggagg gcgagcccct
    19381 gctctgcctc cccggcggcc ccatgcgcgc ctccgcctac ctcggcgatc tcggcggcct
    19441 gtcgcggtac cgccggctgg tccggctcga cctgcgcggc accggcgact ccggcgtccc
    19501 cgccgacccg gcgacctacc gctgtgaccg gcaggtcgac gacgtcgagg cgctgcgcga
    19561 gcacctcggg ctgtcccgcg tcgacatcct cgcgcactcc gcggccggcg acctcgccct
    19621 gctccacgcg gcccgccacc cgcaccgcgt ccgctccctc accctggtcg cctcgcgagc
    19681 ccgggccctg ggcatcgact tcaccgtcga gcaccgccac gaggcggccg acctgcgtgc
    19741 gggcgaaccg tggttccccg gcgcccgtgc cgccttcgac gccctctgga ccggttccgc
    19801 gaccgatgcc gactgggacg ccgcgatgcc gttcttctac ggccgttggg acgccgccgc
    19861 ccgggctcac gccgccgacg agctggccca gaccaacgag ccggccgcgg agcgctacgc
    19921 cgccgccggc gccttcgatc ccgccaccgc ccgcgccgcc ctcgcgcggc tggacgcgcc
    19981 ggtgctggtc ctggccggcg cgtgggacgg cgggccgctg ccccgcgtag ccgccaccgt
    20041 cgccgaggcg ttcccccgcg ccgaactgac cgtccagccg ggcgccggcc actacccgtg
    20101 gctcgacgac cccgccggtt tctccgcgac cgtggcggcc ttcctcgacg cggcgggcac
    20161 ggagggctga gcgactggag ggctgaactt cccttcctcg tcacgaagtt cgggggcatg
    20221 cacatcgagg gcggctgatc gcctccggca tgcgggactt caaggtctgc ttcccggccc
    20281 cggcgcgtac gctgcgccac gccacggccg aggtggggcc ggaggtgtca cgcgcgatca
    20341 gtggtgggtg tccggagtgg atcgccgagc gggtggcggg gtttctccgg ggcggggacc
    20401 gggcccgaag cgaagccggg tgatgagcgg gcggtcgccg cggagcagcg gcagggtccc
    20461 ggcgcgcggc gcgagatagc cgaccaggcc ccggccggcc ggcaggggca cgtcggccac
    20521 ctccgtgatg gccgggtggg cggtgcgcag caggtcccgc tcgtgcgcgt ccatgcccca
    20581 ggacatcgcc ggcagacggt ggccgcccgg ccccttcgcc ccggcacggg tgcgggcgct
    20641 gaagcgccgg gagacggtgt cgaacaccat cgtgccgccg gggaacgccg cggcgcaggc
    20701 ggcgagcagc cgggtggcct gggcccgttg caggtacatc agcaggccct gcgcggtgac
    20761 caggaccccg cgggaggcat cgatgtccgc catccatgtg gtggcgcgga cgtcgcaggc
    20821 gatgagtcgc tgccgcggcc cgtgcggcag gacgcgctcg cgcagcacca acggggcggc
    20881 cagatcgacg ccgacccacc ggacgtgacc gttgtccacc cgccagaact gggtctccag
    20941 tccctcgccg agtgcgatca ccgtgccgtc cgggtgggtg gcgaggaagt cacgcaccac
    21001 ccggtcgaag ccgagggcac gcagggcgat ggcctgcgcc acccaggggc ggacggcgc
//
