LOCUS       NZ_CP019779            10417 bp    DNA     linear   CON 14-MAR-2024
DEFINITION  Streptomyces sp. MOE7 chromosome, complete genome.
ACCESSION   NZ_CP019779
VERSION     NZ_CP019779.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. MOE7
  ORGANISM  Streptomyces sp. MOE7
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8399509)
  AUTHORS   Elnahas,M.O., De Leon,K.B., Amin,M.A., Hussein,M.M.D., Ali,A.E. and
            Wall,J.D.
  TITLE     Complete Genome Sequencing of Streptomyces sp. Strain MOE7, Which
            Produces an Extracellular Polysaccharide with Antioxidant and
            Antitumor Activities
  JOURNAL   Genome Announc 5 (22), e00442-17 (2017)
   PUBMED   28572320
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8399509)
  AUTHORS   Elnahas,M.O., De Leon,K.B., Amin,M.A., Hussein,M.M.D., Ali,A.E. and
            Wall,J.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-FEB-2017) Biochemistry, University of Missouri
            Columbia, 117 Schweitzer Hall, Columbia, MO 65211, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera Assembler v. 8.1
            Genome Coverage                   :: 180.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002090335.1-RS_2024_03_14
            Annotation Date                   :: 03/14/2024 02:19:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,435
            CDSs (total)                      :: 7,344
            Genes (coding)                    :: 7,005
            CDSs (with protein)               :: 7,005
            Genes (RNA)                       :: 91
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 339
            CDSs (without protein)            :: 339
            Pseudo Genes (ambiguous residues) :: 0 of 339
            Pseudo Genes (frameshifted)       :: 230 of 339
            Pseudo Genes (incomplete)         :: 155 of 339
            Pseudo Genes (internal stop)      :: 7 of 339
            Pseudo Genes (multiple problems)  :: 47 of 339
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:50:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2283434
            Orig. end                         :: 2293851
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP019779.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Judy D. Wall 117 Schweitzer
            Hall Columbia, MO USA 65202.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10417
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="10"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10417
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10417
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5417](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5417
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            complement(39..1049)
                     /locus_tag="STRMOE7_RS10260"
                     /old_locus_tag="STRMOE7_10240"
     CDS             complement(39..1049)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536882.1"
                     /locus_tag="STRMOE7_RS10260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_10240"
                     /product="SCO1860 family LAETG-anchored protein"
                     /protein_id="WP_237323931.1"
                     /transl_table=11
                     /translation="MPRRLAATLVATALTAGPAVLLGAAPAHATGGHGPAHGTSGAVVL
                     RAGLNVGLLNKTLDVPLNAVLNEVHAPASANKTALTVNLDGIGHGKPFSVLRADVATAR
                     ATADHRKAEGYANLVHAKVHLPGLPLLSLIEVQQVTATAVCEAGKAPRATSNVLGSVRV
                     LGKKVTLTAGGTTDVKVPGVGEVRLDLSKKSTTARKAAATALDLNVSVNPLKLNVADVR
                     GRVTLVQASCTTPGGTAPRPGGTGGTGGGQPQPGGDTKPAGGTEPAGDSKPAGGKDAQV
                     NQPGSRPSTQNLAETGGSSATPYLAGGAALLVVAGAGSMVYARRRRSAAPQTGRG"
     misc_feature    complement(1165..1182)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.07"
                     /tool="antismash"
     gene            complement(1409..2509)
                     /locus_tag="STRMOE7_RS10265"
                     /old_locus_tag="STRMOE7_10245"
     CDS             complement(1409..2509)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123619.1"
                     /locus_tag="STRMOE7_RS10265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_10245"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_173675706.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 7.1e-16, bitscore:
                     57.1, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSKSEGAVLHLKGRVLVGPDDVRDELWVVGGRVTFDRPVMARDA
                     TTVEGWTLPGLVDAHCHVGLDAHGPVDAPTSEKQALTDRDAGTLLIRDAGSPSDTRWVD
                     DREDLPRIIRAGRHIARTKRYIRNYAHEIEPEDLVAYVAQEARRGDGWVKLVGDWIDRS
                     TGDLSACWPRGAVEAAIAEAHRLGARVTAHCFAEETLAPLVEAGIDCIEHATGLTDDTI
                     PLFAERGVAIVPTLINIATFPQLAAGGQGKYPRWADHMRRLHARRYDTVRAAYDAGVPV
                     FAGTDAGGSLAHGLVAEEVLELTRAGLPAVAALSATTWGARDWLGRPGLTEGAPADLVV
                     YESDPREDVRVLAAPRRVVLRGQVVG"
     misc_feature    complement(2815..2830)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     misc_feature    complement(2825..2840)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.52"
                     /tool="antismash"
     gene            2995..3561
                     /gene="ectA"
                     /locus_tag="STRMOE7_RS10270"
                     /old_locus_tag="STRMOE7_10250"
     CDS             2995..3561
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156969.1"
                     /locus_tag="STRMOE7_RS10270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_10250"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_173675707.1"
                     /transl_table=11
                     /translation="MTAAQADHAGARSDIREIPEGFKLDTPRVEDGAAIWRIARDSKAL
                     DLNSSYSYLLWCRDFAATSVVARDAEGEPAAFLTGYLRPERPETLVVWQIAVDDAHRGK
                     GLAAALLDGLTLRARDELGIRYVETTITPDNAASNRLFASFAERHSVPVKREVLFDAGL
                     FPEQGHEPEVLHLIGPFVPPTPVPG"
     gene            3685..4953
                     /gene="ectB"
                     /locus_tag="STRMOE7_RS10275"
                     /old_locus_tag="STRMOE7_10255"
     CDS             3685..4953
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (28-365). E-value: 2.1e-75.
                     Score: 245.8. Matches aSDomain:
                     nrpspksdomains_STRMOE7_RS10275_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007381147.1"
                     /locus_tag="STRMOE7_RS10275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_10255"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_084770574.1"
                     /sec_met_domain="Aminotran_3 (E-value: 6.9e-76, bitscore:
                     254.2, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITQPDLSVFETVESEVRSYCRGWPTVFDRAQGSRLVDEDGHTY
                     LDFFSGAGSLNYGHNNPVLKRALIDYIERDGITHGLDMSTTAKRAFLESFQNIILRPRD
                     LPYKVMFPGPTGANSVEAALKLARKVKGRESIVSFTNAFHGMSLGALAVTGNSMKRAGA
                     GIPLVHGTPMPFDNYLDGAYPDFLWFERLLEDQGSGLNTPAAVIVETVQGEGGINVARA
                     EWLRALADLCKRRDMLLIVDDIQMGCGRTGAFFSFEEAGIVPDIVTVSKSISGYGLPLA
                     LTLFKPELDIWEPGEHNGTFRGNNPAFVTAAAALDTYWADGQMEKQTLARGEIVEAHLK
                     AIVEEHPGAFAEYRGRGLVWGLECNDKSLAGRIAGRAFELGLLIETSGPESEVVKLLPA
                     LTTTPEELDEGLRTLGRAVRDCV"
     aSDomain        3769..4779
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STRMOE7_RS10275_Aminotran_3.1"
                     /evalue="2.10E-75"
                     /label="STRMOE7_RS10275_Aminotran_3.1"
                     /locus_tag="STRMOE7_RS10275"
                     /protein_end="365"
                     /protein_start="28"
                     /score="245.8"
                     /tool="antismash"
                     /translation="FDRAQGSRLVDEDGHTYLDFFSGAGSLNYGHNNPVLKRALIDYIE
                     RDGITHGLDMSTTAKRAFLESFQNIILRPRDLPYKVMFPGPTGANSVEAALKLARKVKG
                     RESIVSFTNAFHGMSLGALAVTGNSMKRAGAGIPLVHGTPMPFDNYLDGAYPDFLWFER
                     LLEDQGSGLNTPAAVIVETVQGEGGINVARAEWLRALADLCKRRDMLLIVDDIQMGCGR
                     TGAFFSFEEAGIVPDIVTVSKSISGYGLPLALTLFKPELDIWEPGEHNGTFRGNNPAFV
                     TAAAALDTYWADGQMEKQTLARGEIVEAHLKAIVEEHPGAFAEYRGRGLVWGLECN"
     gene            5001..5417
                     /locus_tag="STRMOE7_RS10280"
                     /old_locus_tag="STRMOE7_10260"
     CDS             5001..5417
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606340.1"
                     /locus_tag="STRMOE7_RS10280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_10260"
                     /product="ectoine synthase"
                     /protein_id="WP_033270529.1"
                     /sec_met_domain="ectoine_synt (E-value: 2.2e-52, bitscore:
                     175.0, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFKDIEGTDRHVKAKSGTWESKRIVLAKERVGFSLHETVLY
                     AGTETSMWYANHIEAVVCVEGEAELTNDETGEKHLITPGVMYLLDGHEKHTMRIKEDFR
                     CLCVFNPPVTGREDHDENGVYPVLTEPDPEPEKV"
     gene            5512..6411
                     /gene="thpD"
                     /locus_tag="STRMOE7_RS10285"
                     /old_locus_tag="STRMOE7_10265"
     CDS             5512..6411
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156966.1"
                     /locus_tag="STRMOE7_RS10285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_10265"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_033270530.1"
                     /sec_met_domain="PhyH (E-value: 3e-37, bitscore: 127.6,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAPERIADLYPTRGTAEVITPRKDPVVWSQPGAAGPFAPSELS
                     DFERDGFFAIGELLTAEEVAVYRAELDRLVLDPEMRADPRSIVEPKSQSVRSVFEVHKI
                     SEVFAKLVSDPRVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLP
                     NMRTVSVSIALTENYDTNGGLMIMPGSHQHFVGCEGETPKDHYKRSLQMQDAGIPSDEV
                     LTKMADKHSIRLFTGKAGSATWFDCNAMHGSGDNITPYPRSNVFIVFNSVENAAVEPFA
                     APVRRPEYIGARDFTPVR"
     misc_feature    complement(6485..6496)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            6509..7831
                     /locus_tag="STRMOE7_RS10290"
                     /old_locus_tag="STRMOE7_10270"
     CDS             6509..7831
                     /NRPS_PKS="Domain: Abhydrolase_1 (47-196). E-value:
                     3.7e-17. Score: 54.7. Matches aSDomain:
                     nrpspksdomains_STRMOE7_RS10290_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014145299.1"
                     /locus_tag="STRMOE7_RS10290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_10270"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_084770579.1"
                     /sec_met_domain="PF00561 (E-value: 3.8e-16, bitscore: 58.2,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRADRLPGVVARDHVLEVPLDHDDPGGERLEVYGREVVAAGRERD
                     ELPWLVYLQGGPGCPSPRPVGRESWLKRALEDHRVLLLDQRGTGRSTPANRQTLPLRGG
                     PEQQAAYLAHFRADAIVRDAELFRRRLVPDGGPWSVLGQSFGGFCTVAYLSRAPEALSA
                     AYITGGLPGLDASAEDVYRAAYPRVARKNAAHYARYPEDVAAVRRIVGYLREHEVRLPG
                     GGLLTAEAFLSLGLMLGSGDGSHTLHHLVSEAWVTGPAGPEPADAFLEAVQGQLSHAAT
                     PLFAVLHETIYGQRSVDAGPTGWAAERVRRQLAPADAAFDVDAALAGDGPVYFTGEMMY
                     PWMFDTDPALRPLKETAHALAERTDWPDLYDAGRLAGNEVPAAAAVYFDDMYVDTGHAL
                     RTAERIRGLRVWVTNEWEHDGLRVSDGAVLDRLVRMVRGEV"
     aSDomain        6650..7096
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STRMOE7_RS10290_Abhydrolase_1.1"
                     /evalue="3.70E-17"
                     /label="STRMOE7_RS10290_Abhydrolase_1.1"
                     /locus_tag="STRMOE7_RS10290"
                     /protein_end="196"
                     /protein_start="47"
                     /score="54.7"
                     /tool="antismash"
                     /translation="PWLVYLQGGPGCPSPRPVGRESWLKRALEDHRVLLLDQRGTGRST
                     PANRQTLPLRGGPEQQAAYLAHFRADAIVRDAELFRRRLVPDGGPWSVLGQSFGGFCTV
                     AYLSRAPEALSAAYITGGLPGLDASAEDVYRAAYPRVARKNAAHY"
     gene            complement(7889..8956)
                     /locus_tag="STRMOE7_RS10295"
                     /old_locus_tag="STRMOE7_10275"
     CDS             complement(7889..8956)
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005319060.1"
                     /locus_tag="STRMOE7_RS10295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_10275"
                     /product="alkene reductase"
                     /protein_id="WP_084770581.1"
                     /transl_table=11
                     /translation="MTTAFDPVDLAGIPLANRLVMAPMTRNRATAEGVPTPSMVRYYTQ
                     RASAGLIITEATQTTPVGRGYPLTPGLHTPEQVAGWRAVTDSVHAAGGTIFAQLWHGGR
                     IGHPVLLPDGLLPVAPSPVAAAGQGFTHEGLKDFVTPRELTGQEIAETIAGFATAARNA
                     LDAGFDGVEIHGANGYLVHQFLAPNSNLRTDEWGGSDEARARFAIEVVRAVADAIGAHR
                     TGLRISPGNTFNDISEPAPEATYTALVEAVAPLGLAYLHSCDVRDQELLARLRKRFGGT
                     FVLNPVTDGRPTGPEELPLVEEGRADLLAYGALFLANPDLPRRLAAGGPFNTPDRASFY
                     GGDDSGYLDYPALTD"
     gene            complement(9061..10131)
                     /locus_tag="STRMOE7_RS10300"
                     /old_locus_tag="STRMOE7_10280"
     CDS             complement(9061..10131)
                     /NRPS_PKS="Domain: Aminotran_5 (16-351). E-value: 1.6e-26.
                     Score: 85.0. Matches aSDomain:
                     nrpspksdomains_STRMOE7_RS10300_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606338.1"
                     /locus_tag="STRMOE7_RS10300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_10280"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_084770583.1"
                     /sec_met_domain="Aminotran_5 (E-value: 2.4e-17, bitscore:
                     61.7, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQRHEPLGGAEFAPGTTYLNSASSGLLPRRSAAAVRAALDESASH
                     GTMGRDYFAAAEAARAAFARLVGVPAERVAVGSSVAVQSALIAASLPAGAEVLAPEGDF
                     SSLVNPLGTHPGIKLRTVPLEALADEVRPGTALVAFSAVQSLDGRIADLAAVREAARTH
                     GARTFVDATQAAGWLPLRALDFDYLVAGAFKWLLCPRGTTFMAFGGDRGDRTDGPGWPA
                     ALHAGWVAGEDLAASNYGLITPATTARRFDEPHAYFSYVGAEQSLALIEELGVSAIHAH
                     DTALAAYYRERLTERGLTPRPAPGSAIVSTPGLTDAEDRLTEAGVKISVRGGLLRASFH
                     LYNSTDDVDRLLSLLH"
     aSDomain        complement(9079..10083)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STRMOE7_RS10300_Aminotran_5.1"
                     /evalue="1.60E-26"
                     /label="STRMOE7_RS10300_Aminotran_5.1"
                     /locus_tag="STRMOE7_RS10300"
                     /protein_end="351"
                     /protein_start="16"
                     /score="85.0"
                     /tool="antismash"
                     /translation="TYLNSASSGLLPRRSAAAVRAALDESASHGTMGRDYFAAAEAARA
                     AFARLVGVPAERVAVGSSVAVQSALIAASLPAGAEVLAPEGDFSSLVNPLGTHPGIKLR
                     TVPLEALADEVRPGTALVAFSAVQSLDGRIADLAAVREAARTHGARTFVDATQAAGWLP
                     LRALDFDYLVAGAFKWLLCPRGTTFMAFGGDRGDRTDGPGWPAALHAGWVAGEDLAASN
                     YGLITPATTARRFDEPHAYFSYVGAEQSLALIEELGVSAIHAHDTALAAYYRERLTERG
                     LTPRPAPGSAIVSTPGLTDAEDRLTEAGVKISVRGGLLRASFHLYNSTDDVDRL"
ORIGIN
        1 gcggcgcccc cacagcgccg gcccggggta cggggctgtc agccgcgccc ggtctgcggg
       61 gcggcggaac ggcggcggcg ggcgtagacc atcgagcccg cgcccgcgac gacgagcagg
      121 gccgcgccgc cggcgaggta cggggtggcc gagctgccgc cggtttcggc gaggttctgg
      181 gtgctcggcc gggagcccgg ctggttcacc tgggcgtcct tgccgccggc cggcttgctg
      241 tccccggccg gttcggtgcc cccggccggc ttggtgtcgc cgcccggttg cggctgaccg
      301 ccaccggtgc cgccggtgcc gcccggccgg ggcgccgtgc cgcccggggt ggtgcagctg
      361 gcctggacga gcgtgacccg gccgcggacg tcggcgacgt tgagcttcag ggggttgacg
      421 gagacgttca ggtcgagtgc ggtggccgcg gccttcctgg ccgtggtgct cttcttcgac
      481 aggtcgagcc gcacctcgcc cacgccgggc accttcacgt ccgtcgtccc gcccgccgtg
      541 agcgtgacct tcttgcccag gacgcggacg ctgcccagca cgttcgacgt ggcgcggggg
      601 gccttgccgg cctcgcacac cgcggtggcg gtgacctgct ggacctcgat cagggacagc
      661 agcggcaggc cgggcagatg caccttggcg tgcaccaggt tggcgtagcc ctcggccttg
      721 cggtggtccg cggtggcccg tgcggtggcg acatcggccc gcagcacgct gaacggcttg
      781 ccgtgcccga tgccgtcgag gttgacggtg agggcggtct tgttcgcgga ggccggggcg
      841 tgcacctcgt tgaggacggc gttcagcggg acgtcgagcg tcttgttgag caggccgacg
      901 ttcaggccgg cgcgcagcac gaccgcgccg gacgtgccgt gtgccgggcc gtggccgccg
      961 gtggcgtggg cgggcgcggc gccgagcagg acggcgggac cggccgtcag ggccgtggcg
     1021 acgagggtcg cggcgaggcg cctgggcatg ccggagtggg tgggactggt ggacacgtgt
     1081 gtggaacccc cacaagagaa atggagccgc cggccgcgcc aatgggggac atcacgcggg
     1141 ccgacgacct cgacccgcac atcgtgtccg cactgagggt gaacggggag ccacgcgtgg
     1201 tcagttcatc ccaacgggtg gttttcgcgt ctgcattcga ttcctgtggc acggtgcagc
     1261 tctcgcgtca cagccgcccc accgcgtggg tgacccgggt tgaccggcag cgtttccccc
     1321 ggtcaccgga tcggggcagg gggcgtgaag cggcccggcc cggccggagc cgggccgggc
     1381 cgcaggagga ctccgggggc gcgtcccgct agccgacgac ctgtccccgc aggacgaccc
     1441 ggcgcggggc cgccaggacg cgtacgtcct cgcgcgggtc gctctcgtag accacgaggt
     1501 cggcgggggc gccctcggtg aggccggggc ggccgagcca gtccctggcc ccccaggtgg
     1561 tggcggagag ggcggcgacg gcgggcaggc cggccctggt cagttcgagg acctcctcgg
     1621 cgaccaggcc gtgggcgagc gagccgccgg cgtcggtgcc ggcgaagacg ggcacaccgg
     1681 cgtcgtaggc cgcccgtacg gtgtcgtagc ggcgtgcgtg gaggcgtcgc atgtggtccg
     1741 cccagcgcgg gtacttcccc tggccaccgg ccgcgagctg cgggaacgtg gcgatgttga
     1801 tcagggtggg gacgatcgcg acgccgcgtt cggcgaacag cgggatggtg tcgtcggtga
     1861 ggccggtggc gtgctcgatg cagtcgatcc cggcctcgac gaggggtgcg agggtctcct
     1921 cggcgaagca gtgggcggtc acccgggcgc cgagccggtg cgcctcggcg atggccgcct
     1981 cgaccgcgcc ccggggccag caggcggaca ggtcgccggt ggagcggtcg atccagtcgc
     2041 cgacgagttt gacccagccg tcgccgcggc gggcctcctg ggcgacgtag gcgaccaggt
     2101 cctcgggctc gatctcgtgc gcgtagttgc ggatgtagcg cttggtgcgg gcgatgtggc
     2161 ggccggcccg gatgatccgc ggaaggtcct cgcggtcgtc gacccagcgg gtgtcggagg
     2221 gtgaccctgc gtcgcggatc agcagggtgc cggcgtcacg gtccgtgagc gcctgtttct
     2281 cgctggtggg ggcgtccacc gggccgtgtg cgtccagacc cacgtggcag tgggcgtcga
     2341 cgaggccggg cagggtccag ccctccaccg tggtggcatc gcgtgccatg accggccggt
     2401 cgaaggtgac gcggccgccg acgacccaca gctcgtcgcg tacgtcgtcc ggcccgacga
     2461 ggaccctccc cttgaggtgc agcaccgcac cttcactctt ggacgtcata caggcacttt
     2521 aggcggcgcg gccgagccgg cggggcgggg tggcgggggt cttggcggcg gggagccggg
     2581 ggtgccggga gccgggcgtt cccggaggtt tcccaaaatc gcggcgcatg aggttgcgag
     2641 ccttgtcatg ggtttgccgg gcaggtttac ataggcccta cgcaaggtct tccgccggcg
     2701 aattcccaat ttcccggatg tacagcttcc cgtattcttc tgcccgcttt tccgcagctc
     2761 aaacgccaag attttgctag tacggatccc gtaattcgga cgcatctcag gagcgttacg
     2821 cagctgtgac cgactacaca gcgtgtccgt ttcgccccga acatcctggg caaatcgtga
     2881 caagtttcag tctgatcgca cgcacaggcg cgcccgcgcg ataacatatc cagctcgttt
     2941 acgtaacccc tgcccgcgat gcaatttcct tttcgcctgg gtaaattcaa ttgcatgacc
     3001 gccgcacaag cagaccatgc aggtgcccgc agcgatatca gagaaattcc ggagggcttc
     3061 aagctcgaca ctccacgtgt ggaggacggc gcagcgatct ggcgcatcgc ccgtgactcg
     3121 aaggcgctgg acctcaactc gtcctacagc tacctgctgt ggtgtcgtga cttcgccgcc
     3181 acctccgtcg tcgcccgcga cgcggagggc gagccggccg ccttcctcac cggctacctc
     3241 cgccccgagc gcccggagac gctggtcgtc tggcagatcg ccgtcgacga cgcgcaccgt
     3301 ggcaaggggc tggcggccgc actcctggac ggactgacgc tccgcgccag ggacgagctg
     3361 ggcattcgtt acgtcgagac caccatcaca cccgacaacg ccgcgtccaa caggttgttc
     3421 gcgtccttcg ccgagcggca ctccgtgccg gtcaagcgcg aggtgctctt cgatgcgggg
     3481 ctgttccccg agcagggcca cgagccggag gtgctccacc tcataggccc gttcgtgcct
     3541 cccacccctg tccccgggta gtagcgcccc cgggccgcgc ggcgacggcg ccgcgccggc
     3601 cccgcggatc cggccgcccg caagggccgc cggcaccgcc cacagacttc ctcatccttc
     3661 gcactcatct cccaggagca tgctgtgacc atcacccagc ccgatctgag cgtcttcgag
     3721 accgtggagt cggaggtgcg cagctactgc cgtggctggc ccaccgtctt cgaccgtgcc
     3781 cagggcagcc gtctggtcga cgaggacggg cacacctacc tggacttctt ctccggagcc
     3841 gggtcgctca actacggaca caacaacccg gtcctcaaac gcgccctgat cgactacatc
     3901 gagcgggacg gcatcaccca cggcctggac atgtccacca cggccaagcg ggcgttcctg
     3961 gagtcgttcc agaacatcat cctgcggccg cgtgacctgc cgtacaaggt catgttcccc
     4021 gggccgacgg gcgccaactc ggtcgaggcg gcgctgaagc tcgcccgcaa ggtcaagggc
     4081 cgcgagtcga tcgtgtcctt caccaacgcc ttccacggca tgtcgctggg cgcgctcgcg
     4141 gtcaccggta actccatgaa gcgggccggt gccggtatcc cgctggtgca cggcaccccg
     4201 atgccgttcg acaactacct ggacggggcg tacccggact tcctgtggtt cgagcggctg
     4261 ctggaggacc agggttccgg cctgaacacg cccgccgcgg tgatcgtgga gacggtccag
     4321 ggcgagggcg gcatcaacgt ggcccgcgcc gagtggctgc gggcgctggc cgacctgtgc
     4381 aagcgccggg acatgctgct gatcgtcgac gacatccaga tgggctgcgg ccgtacgggt
     4441 gccttcttct ccttcgagga ggcgggcatc gtgccggaca tcgtcaccgt ctcgaagtcg
     4501 atcagcggct acggtctgcc gctggcgctc accctgttca agcctgagct ggacatctgg
     4561 gagccgggcg agcacaacgg cacgttccgc ggcaacaacc cggccttcgt gacggccgcc
     4621 gccgcgctgg acacctactg ggccgacggc cagatggaga agcagaccct cgcccgcggt
     4681 gagatcgtcg aagcgcacct gaaggccatc gtcgaggagc acccgggcgc ctttgccgag
     4741 taccgcggcc gcggtctggt gtggggtctg gagtgcaacg acaagagcct cgcgggccgg
     4801 atcgcgggcc gggccttcga gctgggcctg ctgatcgaga cctccggtcc ggagagcgag
     4861 gtcgtcaaac tgctgcccgc gctgaccacc acccccgagg agctggacga gggccttcgg
     4921 accctcggcc gcgcggtccg cgactgcgtc tgagacccgt cagagttcct gcacgttcaa
     4981 cagaaaggca ccgacccacc gtgatcgtcc gatccttcaa ggacatcgag ggcaccgacc
     5041 gccacgtcaa ggccaagtcc ggtacgtggg agagcaagcg catcgtgctc gccaaggagc
     5101 gcgtcgggtt ctcgctgcac gagaccgttc tgtacgccgg tacggagacg tcgatgtggt
     5161 acgcgaacca catcgaggcc gttgtctgcg tcgagggcga ggccgagctg accaatgacg
     5221 agaccggcga gaagcacctc atcacgcccg gcgtgatgta cctgctcgac gggcacgaga
     5281 agcacaccat gcggatcaag gaggacttcc gctgcctgtg cgtcttcaac ccgccggtca
     5341 ccggccgcga ggaccacgac gagaacgggg tctacccggt tctcaccgag ccggacccgg
     5401 agccggagaa ggtctgaggc gaccccgggc cggcccgtca gggccggccg cggaagcccc
     5461 gcgtcacgca cgtgagccgg attccgtacg agaggagagg aaggcaacac catgaccacc
     5521 gcacccgagc gcatcgccga cctgtacccg acccggggga ccgccgaggt catcaccccg
     5581 cggaaggacc cggtggtgtg gtcgcagccc ggagcagccg gcccgttcgc gccgtccgag
     5641 ctgagcgact tcgaacgcga cggctttttc gccatcgggg agctgctgac ggcggaagaa
     5701 gtcgcggtgt accgcgccga actggaccgg ctggtgctcg acccggagat gcgcgccgac
     5761 ccgcgctcca tcgtcgagcc gaagtcgcag agcgtccggt ccgtcttcga ggtgcacaag
     5821 atcagtgagg tgttcgccaa gctggtctcc gacccgcggg tggtcggccg ggcccggcag
     5881 atcctcggtt cggacgtcta cgtccaccag tcgcggatca atgtgaagcc cggcttcggt
     5941 gcttccggct tctactggca ctcggacttc gagacctggc acgcggagga cgggctgccg
     6001 aacatgcgga ccgtgtccgt gtcgatcgcg ctgaccgaga actacgacac caacggcggc
     6061 ctgatgatca tgcctggttc gcaccagcac ttcgtcggct gcgagggcga gacgccgaag
     6121 gaccactaca agcggtcgct ccagatgcag gacgcgggca tcccgtcgga cgaggtgctg
     6181 acgaagatgg cggacaagca cagcatccgg ctgttcacgg gcaaggccgg ttcggcgacg
     6241 tggttcgact gcaacgccat gcacggctcg ggtgacaaca tcacgccgta cccccgcagc
     6301 aatgtcttca tcgtcttcaa cagcgtggag aatgccgcgg tggagccgtt cgcggcgccg
     6361 gtgcggcgcc cggaatacat cggggcgcgg gacttcaccc cggtgcgctg agtacggtga
     6421 catagacgag agcgttaccg gtggcgcggt cgtcgcacag cagggtctgt gcggcggccg
     6481 cgccgcgttc gtgtgcgagg aggggctgat gagggcggac cggctgccgg gggtcgtggc
     6541 gcgcgaccat gtgctcgagg tgccgctgga tcatgacgat ccgggcgggg aacggctgga
     6601 ggtgtacggc cgggaggtgg tggccgccgg gcgggagcgg gacgagctgc cgtggctggt
     6661 gtatctgcag ggcggccccg ggtgtccgtc gccgcggccg gtggggcggg agtcctggct
     6721 gaagcgggcg ctggaggacc accgggtgct gctgctggac cagcgcggta cggggcggtc
     6781 gacgccggcg aaccggcaga cgctgccgct gcgcggcggc ccggagcagc aggcggcgta
     6841 cctggcgcat ttccgggcgg acgcgatcgt gcgggacgcc gagctgttcc gccgtcgcct
     6901 ggtcccggac ggcgggccgt ggagcgtgct gggccagagc ttcggcgggt tctgcacggt
     6961 cgcttacctc tcccgggcgc cggaggcact gtcggcggcg tacatcacgg gtgggctgcc
     7021 cggtctggac gcgagtgccg aggacgtgta ccgggcggcg tatccgcggg tggcgcggaa
     7081 gaacgcggcg cactacgcgc ggtatcccga ggacgtggcg gcggtgcggc ggatcgtggg
     7141 gtacctgcgg gagcacgagg tgcggctgcc cggcgggggg ctgctgaccg cggaggcgtt
     7201 cctgtcgctg gggctgatgc tgggcagcgg cgacgggtcg cacaccctgc accacctcgt
     7261 gagtgaggcg tgggtgacgg gcccggccgg cccggagccg gccgacgcgt tcctggaggc
     7321 cgtacagggt cagctgtcgc atgccgcgac gccgttgttc gcggtgctgc acgagacgat
     7381 ctacgggcag cggtcggtgg acgcggggcc gacgggctgg gcggcggagc gggtgcggcg
     7441 gcaactggcg ccggcggacg cggcgttcga cgtggacgcg gcgctggccg gggacggacc
     7501 ggtgtacttc accggggaga tgatgtaccc gtggatgttc gacacggatc cggcgctgcg
     7561 gccgttgaag gagaccgcgc acgcgctggc ggagcggacg gactggccgg atctgtacga
     7621 cgccgggcgg ctggccggca acgaggtgcc ggccgcggcg gcggtctact tcgacgacat
     7681 gtacgtcgac accggtcacg cgctgcggac cgcggagcgg atccggggcc tgcgggtgtg
     7741 ggtgacgaac gagtgggagc acgacgggct gcgggtcagt gacggggcgg tgctggaccg
     7801 gctggtgcgg atggtgcgcg gagaggtgtg agcgggccgg cggggcgcac ggagcgcccc
     7861 gccggtgcgt cgccgcgtcg ccgcgtgctc agtcggtcag ggccgggtag tcgaggtagc
     7921 cgctgtcgtc gccgccgtag aagctggcgc ggtcgggggt gttgaagggg ccgccggcgg
     7981 cgaggcggcg gggcaggtcc gggttggcga ggaagagcgc gccgtacgcc agcaggtcgg
     8041 cccggccctc ctcgacgagc gggagctctt cggggccggt ggggcggccg tcggtgaccg
     8101 ggttgaggac gaaggtgccg ccgaagcgct tgcgcagccg ggccagcagc tcctggtcgc
     8161 ggacgtcgca gctgtgcagg taggccaggc ccagcggggc gaccgcttcg acgagcgcgg
     8221 tgtaggtggc ctcgggggcg ggctcggaga tgtcgttgaa ggtgttgccc ggggagatgc
     8281 gcaggccggt gcggtgggcg ccgatcgcgt cggcgacggc ccgtacgacc tcgatggcga
     8341 agcgggcgcg ggcttcgtcg gagccgcccc actcgtcggt gcgcaggttg ctgttggggg
     8401 cgaggaactg gtggacgagg tagccgttgg cgccgtggat ctcgactccg tcgaaaccgg
     8461 cgtcgagggc gttgcgggcg gcggtggcga agccggcgat cgtctcggct atctcctggc
     8521 cggtcagttc gcggggcgtg acgaagtcct tgaggccctc gtgggtgaag ccctggccgg
     8581 ccgcggccac cggtgagggg gcgacgggca gcaggccgtc gggcagcagc acggggtggc
     8641 cgatccggcc gccgtgccac agctgcgcga agatcgtgcc gcccgcggcg tgcacggagt
     8701 cggtgaccgc acgccatccg gcgacctgtt cgggggtgtg caggcccggg gtgagcgggt
     8761 agccgcggcc gacgggggtg gtctgggtgg cttcggtgat gatgagtccg gcggaggccc
     8821 gctgggtgta gtagcggacc atcgaagggg tggggacgcc ttcggcggtg gcgcggttgc
     8881 gggtcatcgg cgccatcacg aggcggttgg cgagcgggat gccggcgagg tcgacggggt
     8941 cgaaagcggt ggtcactgaa ggggcctctc aactgctgtc cggagcacgg ggtcagacgt
     9001 gacgtcagcg gtgccaacct cgccggcggg tccccgcatt cccggggccg ctgtccggtg
     9061 tcagtgcagc agggacagca gccggtcgac gtcgtcggtg gagttgtaga ggtggaagga
     9121 cgcgcgcagc agcccgccgc gtacggagat cttcacgccg gcctcggtga gccggtcctc
     9181 ggcgtccgtc aggccggggg tggagacgat ggcggagccg ggcgcggggc ggggcgtcag
     9241 gccgcgttcg gtgagccgct cgcggtagta cgcggcgagc gcggtgtcgt gggcgtggat
     9301 ggcggatacg ccgagttcct cgatgagggc gagcgactgt tcggcgccga cgtacgagaa
     9361 gtaggcgtgc ggttcgtcga agcggcgggc ggtggtggcc ggggtgatca ggccgtagtt
     9421 ggacgcggcg aggtcctcgc cggccaccca gccggcgtgc agcgcggcgg gccagccggg
     9481 gccgtcggtg cggtcgccgc ggtcgccgcc gaaggccatg aaggtggtgc cgcgcgggca
     9541 cagcagccat ttgaaggcgc cggcgacgag gtagtcgaag tcgagggcgc gcagcggcag
     9601 ccagccggcg gcctgggtgg cgtcgacgaa ggtgcgggcc ccgtgggtcc gggcggcttc
     9661 ccgtacggcg gcgaggtcgg cgatccggcc gtcgagcgac tggacggcgc tgaaggcgac
     9721 cagcgcggtg ccggggcgca cctcgtcggc gagcgcttcc agggggacgg tgcgcagctt
     9781 gatgcccggg tgggtgccga gcgggttgac cagggagctg aagtcgcctt cgggggcgag
     9841 gacttcggcg cccgccggga gggaagcggc gatcagcgcg gactggacgg cgacggaact
     9901 gccgacggcg acccgctcgg cggggacgcc caccagccgg gcgaaggcgg cccgggcggc
     9961 ttcggcggcg gcgaagtagt cgcggcccat cgtgccgtgc gaggcggatt cgtcgagggc
    10021 cgcgcgcact gcggcggcgc tgcggcgtgg aaggagtccg ctggaggcgg agttgaggta
    10081 cgtcgtcccg ggcgcgaatt cggccccgcc gagtggctca tgtcgctgca tgaccccact
    10141 gtgctcggcg ggggccggtc gcgtccattg tctttcggac ggtgtcaggc gccgggtacg
    10201 gcgcagccct cgtccccgca gacctctccg tcgggagcgg cgagggtctg gatcgcgccg
    10261 tcggcgtggg cccgctccag ggcctggcgg aagacgtcgg cgggctggcc gccggagatg
    10321 ccgtagcggc ggtcgatgac gaagaagggg acgccggtgg cgccgagcgc ggcggcctcg
    10381 cgctcgtcgg cgcgtacctc ctgggcgtac gcggcgg
//
