LOCUS       NZ_CP019779            22613 bp    DNA     linear   CON 14-MAR-2024
DEFINITION  Streptomyces sp. MOE7 chromosome, complete genome.
ACCESSION   NZ_CP019779
VERSION     NZ_CP019779.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. MOE7
  ORGANISM  Streptomyces sp. MOE7
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8399509)
  AUTHORS   Elnahas,M.O., De Leon,K.B., Amin,M.A., Hussein,M.M.D., Ali,A.E. and
            Wall,J.D.
  TITLE     Complete Genome Sequencing of Streptomyces sp. Strain MOE7, Which
            Produces an Extracellular Polysaccharide with Antioxidant and
            Antitumor Activities
  JOURNAL   Genome Announc 5 (22), e00442-17 (2017)
   PUBMED   28572320
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8399509)
  AUTHORS   Elnahas,M.O., De Leon,K.B., Amin,M.A., Hussein,M.M.D., Ali,A.E. and
            Wall,J.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-FEB-2017) Biochemistry, University of Missouri
            Columbia, 117 Schweitzer Hall, Columbia, MO 65211, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera Assembler v. 8.1
            Genome Coverage                   :: 180.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002090335.1-RS_2024_03_14
            Annotation Date                   :: 03/14/2024 02:19:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,435
            CDSs (total)                      :: 7,344
            Genes (coding)                    :: 7,005
            CDSs (with protein)               :: 7,005
            Genes (RNA)                       :: 91
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 339
            CDSs (without protein)            :: 339
            Pseudo Genes (ambiguous residues) :: 0 of 339
            Pseudo Genes (frameshifted)       :: 230 of 339
            Pseudo Genes (incomplete)         :: 155 of 339
            Pseudo Genes (internal stop)      :: 7 of 339
            Pseudo Genes (multiple problems)  :: 47 of 339
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:50:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 815726
            Orig. end                         :: 838339
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP019779.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Judy D. Wall 117 Schweitzer
            Hall Columbia, MO USA 65202.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22613
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="4"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22613
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22613
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12613](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12613
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    414..428
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.15"
                     /tool="antismash"
     misc_feature    complement(460..475)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: strong, score: 25.48"
                     /tool="antismash"
     misc_feature    complement(515..530)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.44"
                     /tool="antismash"
     misc_feature    520..535
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.15"
                     /tool="antismash"
     gene            654..1031
                     /locus_tag="STRMOE7_RS03720"
                     /old_locus_tag="STRMOE7_03705"
     CDS             654..1031
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014057039.1"
                     /locus_tag="STRMOE7_RS03720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_03705"
                     /product="DUF2267 domain-containing protein"
                     /protein_id="WP_033265012.1"
                     /transl_table=11
                     /translation="MDDKEFFRAVAERSGLSRQEAADLTRATLDTLGHRLSAGEARDLA
                     LELPEPLRGSLQSGQGEMEIFGPDESIRRVGEHTGLTEPEAARGVRAVLSTLQEAISQK
                     EFAHAMSQLGKEYAQLVESTR"
     gene            complement(1110..1352)
                     /locus_tag="STRMOE7_RS38835"
     CDS             complement(1110..1352)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039508.3"
                     /locus_tag="STRMOE7_RS38835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5701 family protein"
                     /protein_id="WP_237323505.1"
                     /transl_table=11
                     /translation="MATLAGRGRTLLTIEEGIALLTHFPEVLVKNKCFSLGGSRSGDRR
                     VPAIWISQKAPKLGWCWQGNPHTWLGMASAGARRA"
     gene            complement(1316..1765)
                     /locus_tag="STRMOE7_RS38840"
     CDS             complement(1316..1765)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039508.3"
                     /locus_tag="STRMOE7_RS38840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5701 family protein"
                     /protein_id="WP_237323506.1"
                     /transl_table=11
                     /translation="MTPTPFDAGAEFDRQVRNLTDRDYPALSGLDPERFGALLAPLRAH
                     AVAAAAGGRCAPETGRVPFLLVVTRNLVPVEETMPRTVLHGGRLPGFIDGSFEPGALER
                     FVATEETALPAPDAYLLLDVERGRSSAVRYRTKPWRPSPGGAAPC"
     gene            complement(1819..2703)
                     /locus_tag="STRMOE7_RS38845"
     CDS             complement(1819..2703)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020118445.1"
                     /locus_tag="STRMOE7_RS38845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="virginiamycin B lyase"
                     /protein_id="WP_237323907.1"
                     /transl_table=11
                     /translation="MGRWLADPVRDHTVSGPDAGPYALAEGPDGALWFTLVHQGAIGRR
                     DAAGHLTVHPVGAGPTVITQGPDGALWFTEYGTHRIGRITVDGEVSAFEPPTAGGGPFG
                     IAPGPDGALWFTLSAADRIGRLTTSGEFTEYPAPGAFPSALVAGPDGAMWCTLNQADVI
                     GRIAMDGRTTAFPLPTEGAAPVGITAGPDGALWFTEIGAGQIGRITVDGTVTEYPLPDR
                     QARPHALTTGPDGALWFTEWGSGRVGRLTTDGRFTGYDLPRPDSEPHGIAVYRGAVWCA
                     LETGSLAAVEVSR"
     gene            complement(<2749..3513)
                     /locus_tag="STRMOE7_RS38850"
                     /pseudo=""
     CDS             complement(<2749..3513)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066: alpha/beta hydrolase domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019474.4"
                     /locus_tag="STRMOE7_RS38850"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase fold domain-containing
                     protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MQLAHDGGPLLTLTAVPAGPGQAQAVRDRIGALVSGPLPADAEVR
                     GDWVRAPGAGGGAVIYVHGGGFTDTWPEAERMMAYRLSRTTGRPALRVAYRLAPAHPYP
                     AALDDVLAAWRGVLETGVPASEVVFVGESAGATLVLSALLEIKRTGGPLPGAAVAVSPV
                     TDLALTGASLTANDGKDLIDRAVLAAVSDRYLAGAGPRQAPQSPLYGDLRGLPPLLVAV
                     GTDEVLLDDARRFAEAADAAGVSVRLDTYEDAP"
     misc_feature    complement(3567..3583)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.75"
                     /tool="antismash"
     misc_feature    3570..3583
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.65"
                     /tool="antismash"
     gene            3599..4258
                     /locus_tag="STRMOE7_RS03735"
                     /old_locus_tag="STRMOE7_03720"
     CDS             3599..4258
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004000420.1"
                     /locus_tag="STRMOE7_RS03735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_03720"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_084769533.1"
                     /transl_table=11
                     /translation="MGIESSSTTDAAAPGLRAAKKRETRQLISDRATRLFVEQGFERTT
                     IAEIADAARVAKKTVTNYFPRKEDLALDHQDAFVAGPARTVEDRRPGESALAALRRGFL
                     SAVTAQDPVAGFAGPEFTRMIAESPTLTACLRSLHDQREDALTAALAEATGAARDDITP
                     RTAAALLGGVHRLLFRRIQELTLAGRPGPEIAAVLAEEADRAFAVLEPALADYARA"
     gene            4468..5490
                     /locus_tag="STRMOE7_RS03740"
                     /old_locus_tag="STRMOE7_03725"
     CDS             4468..5490
                     /NRPS_PKS="Domain: PKS_ER (19-266). E-value: 6.2e-12.
                     Score: 37.2. Matches aSDomain:
                     nrpspksdomains_STRMOE7_RS03740_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982795.1"
                     /locus_tag="STRMOE7_RS03740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_03725"
                     /product="alcohol dehydrogenase"
                     /protein_id="WP_084769534.1"
                     /sec_met_domain="ADH_N (E-value: 5.5e-28, bitscore: 95.8,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 3.1e-20, bitscore:
                     71.3, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAYRVAQVAAAGGSFEIVEREVPRPGPGQVRLAVEACGICHSDT
                     FFVQAALPGVRFPLVPGHEIAGRIDEIGEATPGDWQVGDRVVVGWFGGSCHACTPCRRG
                     DFIVCENLKVPGWAYDGGFGEAVIAPADALARIPDAVPAADAGPMACAGVTTFNGLRRS
                     SARPGDLVAVLGIGGLGHLGVQYAAAMGFETVALARGADKADFARQLGAHHYIDTTADT
                     PVGDALQALGGAKAVLATAANSQAITATVDGLSPRGELIVIGADTEPLGISPNQLLMQG
                     KVVRGHPSGTAQDVQETIAFSALHGIRPMIETMPLDRADEAYRKMLSGAARFRMVLTTD
                     "
     aSDomain        4525..5265
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STRMOE7_RS03740_PKS_ER.1"
                     /evalue="6.20E-12"
                     /label="STRMOE7_RS03740_PKS_ER.1"
                     /locus_tag="STRMOE7_RS03740"
                     /protein_end="266"
                     /protein_start="19"
                     /score="37.2"
                     /tool="antismash"
                     /translation="EREVPRPGPGQVRLAVEACGICHSDTFFVQAALPGVRFPLVPGHE
                     IAGRIDEIGEATPGDWQVGDRVVVGWFGGSCHACTPCRRGDFIVCENLKVPGWAYDGGF
                     GEAVIAPADALARIPDAVPAADAGPMACAGVTTFNGLRRSSARPGDLVAVLGIGGLGHL
                     GVQYAAAMGFETVALARGADKADFARQLGAHHYIDTTADTPVGDALQALGGAKAVLATA
                     ANSQAITATVDGLSPRGELIVIGAD"
     gene            complement(5660..6397)
                     /locus_tag="STRMOE7_RS03745"
                     /old_locus_tag="STRMOE7_03730"
     CDS             complement(5660..6397)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (38-141). E-value: 5.5e-15. Score:
                     46.3. Matches aSDomain:
                     nrpspksdomains_STRMOE7_RS03745_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014151373.1"
                     /locus_tag="STRMOE7_RS03745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_03730"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_084769535.1"
                     /transl_table=11
                     /translation="MNREQMSRIAHTGHPIKAPLDDESVRRLLERGTPRGDERLLDLGC
                     GSAEWLLRALAARPQLHAVGVDISEDALAQAREAADRRGVGERLVLHHAAAADFVSPDP
                     FDVVLSVGAAHAFGGLLPTLAAARAHLAPGGAVLIGDGFWEHPPSPEAIEMLGDFADLA
                     TTVDRVVADGWTPVHGHVSTRQELDAYEWACWGTLAAWGLDHAGDPDGPEALAMAATRR
                     SEWLRSYRDTWGFVTLILRRTAD"
     aSDomain        complement(5975..6283)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STRMOE7_RS03745_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="5.50E-15"
                     /label="STRMOE7_RS03745_oMT.1"
                     /locus_tag="STRMOE7_RS03745"
                     /protein_end="141"
                     /protein_start="38"
                     /score="46.3"
                     /tool="antismash"
                     /translation="RLLDLGCGSAEWLLRALAARPQLHAVGVDISEDALAQAREAADRR
                     GVGERLVLHHAAAADFVSPDPFDVVLSVGAAHAFGGLLPTLAAARAHLAPGGAVLIGD"
     gene            complement(6509..7600)
                     /locus_tag="STRMOE7_RS03750"
                     /old_locus_tag="STRMOE7_03735"
     CDS             complement(6509..7600)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005310367.1"
                     /locus_tag="STRMOE7_RS03750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_03735"
                     /product="hypothetical protein"
                     /protein_id="WP_084769537.1"
                     /transl_table=11
                     /translation="MSDEEWERFLRESVAGSAGAPVEPSARAREVERRLRERSGESTGW
                     RTYAPARPRRRTGWYVTGLVAAVVLLVVGLFPEQVVGWFGGSDGGRDGAPLAAESESPR
                     EAPGAEPALRATLAEPFRGSPAVHWADGAAGITVPPAEATGWMDAAQVERALRQSRDFL
                     VAAGLDSRVLRGERPTKAIALLNPHQKDVQEYLRTALSSTAPSPETNPLLLFSRFRTQQ
                     ARLVGEVIKTRGRLAYRKGKRGAVEVTADVTFVYPVTPAGDGGRDAEVVRTIVRRKVVM
                     SWDDPAKVITEPGTMSLVSYALDMTNGGCAAPTGYFVPPFGTAGEQPADKAHRVDPYDR
                     SRPIDTSHGTTVTRNGCATATRS"
     misc_feature    complement(7729..7749)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.33"
                     /tool="antismash"
     gene            complement(7735..8646)
                     /locus_tag="STRMOE7_RS03755"
                     /old_locus_tag="STRMOE7_03740"
     CDS             complement(7735..8646)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010360992.1"
                     /locus_tag="STRMOE7_RS03755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_03740"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_084769539.1"
                     /transl_table=11
                     /translation="MDPHLLRTFVAVVEHRSFSAAAQDLGYTQSAVSQHIAALEADLGT
                     RLVGRRPVAATEAGRRLLEHARPLLLRLDAARADLARLRDVRPARLAVDCGPAALTPDW
                     AGALARIRQALPGLAVTVRVRGREAVLRAVLTGDADLALVDGVTAPSDPLPLPDTGTLT
                     TLAVGEQPLVILLPSGHPLAGRRGLRLADLADAHWLDAPDAAVPLGRLRAAAHTDGFRA
                     HATYEGTDLRALGALVAGGNGLAALPSTAADGLPGTVAVPVSAPRLVHRTEALHPKAPA
                     TAVEKLLAEPGLVRGAGAFPAA"
     misc_feature    complement(8699..8713)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.76"
                     /tool="antismash"
     gene            8740..9453
                     /locus_tag="STRMOE7_RS03760"
                     /old_locus_tag="STRMOE7_03745"
     CDS             8740..9453
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016642269.1"
                     /locus_tag="STRMOE7_RS03760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_03745"
                     /product="hypothetical protein"
                     /protein_id="WP_084769541.1"
                     /transl_table=11
                     /translation="MAPHARIALVGDRSPNVRSHLRVPVLLDALRHRDGLDLDAYWIPT
                     EEAEEGIAGFDAVWVLPGSPYRSESGALAAVRAVREGQVPFLGTCGGFQHALLEYARNV
                     CGLHRADHAENSPGADLGSAVIVPLACSLVGHEGAIRLTPGSRAAQLLGAERTVERYHC
                     NYGPNPAHLDTLRAHGLRFTGTDEAGDVRIAELPGHPFFLTTLFQPELHGDGTRPHPLV
                     TGLARAAVRHAAEAG"
     gene            9566..9739
                     /locus_tag="STRMOE7_RS03765"
                     /old_locus_tag="STRMOE7_03750"
     CDS             9566..9739
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017949262.1"
                     /locus_tag="STRMOE7_RS03765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_03750"
                     /product="CsbD family protein"
                     /protein_id="WP_084769542.1"
                     /transl_table=11
                     /translation="MTAEKKTSAKADQLKGAVKETLGRAVGNERMTAEGRAERAMGDMR
                     EAGHKAKDALKR"
     gene            10001..12613
                     /gene="lanKC"
                     /locus_tag="STRMOE7_RS03770"
                     /old_locus_tag="STRMOE7_03755"
     CDS             10001..12613
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020551010.1"
                     /locus_tag="STRMOE7_RS03770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_03755"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_084769545.1"
                     /sec_met_domain="micKC (E-value: 9.1e-245, bitscore: 813.3,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 8.5e-11, bitscore: 40.4,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 9.1e-12, bitscore:
                     43.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKGYAVFCDADRQFYDAPHRFPSDEEGRGALYPVLRRELPDGWQ
                     RHRSGDWLAFRPLDRELPSQGWKIHVSACLDNAERILEKVWDYCVPRSVAFKCMPSRYL
                     LHIRNAKYTDRGASGKFVTVYPADAEQCRVIAEELDALLAGEPGPYILSDLRWGAGPVY
                     VRYGSFTERHCYDDKGELCPAIEDDRGRLVPDRREPAFRVPEWVDLPDFLKPHLDARSA
                     TTVTDLPYAIERALHFSNGGGVYVGRDLRTERRVVLKEGRPHAGLAADGADAVARLERE
                     RDALRRLSGLGCAPEVLDWFTLGEHTFLVLEYIEGRPLNSFFAHRHPLIEADPSPERLA
                     EYTRWALRVHRLVEEAVETIHARGVVFNDLHLFNIMLSEDESSVVLLDFEAASVDDPGS
                     RQVIANPGFVAPADRRGADVDRYALACLRLALFLPLTSLFAVDRHKARHLARIAAEQFP
                     VPREFLDAAVTEILRGHPVPHTPAPAQQPSADAYLPVKLADWPHSRDSAVRAVLASATP
                     EREDRLFPGDIAQFATAGGGTCFAYGAAGVLYALAATGAERCPDAEEWLLQRTKSPASG
                     SPLGFYDGLSGVAWVLDRLGHRERALDLVDLVTAQSWQDIAPDLHSGLAGVGLALDELA
                     GSTGESAARDQALRCAELVAHRLRSAPPPTAPADGTAAPSRAGLLHGDSGAALLFLRLY
                     ERTGDGALLDLAAEALRRDLARCVRSAGGTLQVNEGWRTMPYLGAGSVGIGMVLDDYLA
                     HRPDDAFAAARDEIVKAAQAKFYAQPGLFRGAAGMVLYLSRTTATGPGTDAADLHRQIE
                     SLSWGAVPYQGHLAFAGEQMMRLSMDLSTGTAGCLLALGSALHDSPVHLPFLPPLRRP"
     misc_feature    11477..11479
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12676..12804
                     /locus_tag="STRMOE7_RS03775"
                     /old_locus_tag="STRMOE7_03760"
     CDS             12676..12804
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018849360.1"
                     /locus_tag="STRMOE7_RS03775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_03760"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_033265003.1"
                     /transl_table=11
                     /translation="MSLLDLQTMETPKPEGTEELHTGSRASLLLCGDSSLSVTTCN"
     CDS_motif       12676..12738
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSLLDLQTMETPKPEGTEELH"
                     /locus_tag="STRMOE7_RS03775_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12739..12804
                     /prepeptide="core"
                     /locus_tag="STRMOE7_RS03775_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="12.30"
                     /molecular_weight="1941.2"
                     /monoisotopic_mass="1940.0"
                     /core_sequence="TGSRASLLLCGDSSLSVTTCN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSLLDLQTMETPKPEGTEELH"
                     /leader_location="[12675:12738](+)"
                     /alternative_weights="1959.2"
                     /alternative_weights="1977.2"
                     /alternative_weights="1995.2"
                     /alternative_weights="2013.2"
                     /alternative_weights="2031.3"
                     /alternative_weights="2049.3"
     misc_feature    12683..12703
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.61"
                     /tool="antismash"
     gene            12934..14703
                     /locus_tag="STRMOE7_RS03780"
                     /old_locus_tag="STRMOE7_03765"
     CDS             12934..14703
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019983509.1"
                     /locus_tag="STRMOE7_RS03780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_03765"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_084769549.1"
                     /transl_table=11
                     /translation="MPAPSGPPSPTRPPATGRKPDPGAAVLTDAFRHSPVHTVAVCLFG
                     VAGAAVALALPAVLGHTLDLLLDSAPGVGAALMLSAVLLVADVLLDALVALAGGVTTAR
                     STAWLRRRGIGHLLSLAPHRAADRFTAGDLVTRLTGNAAEAGTAPTTAATGLAAVLTPV
                     GALVALAVTDVWLAAVFLAGLPLLTRLLRTFAQGSSDCVRRYQRVQAEIASRLVEALGG
                     ARTIAAAGTGARERARVLAPLPELDAHGRLMWQVYGRAVVGSSILVPLLTTVVLAVGGL
                     RLAHGALTVGELLAASRYAALTAALGGVTGQLNALVRGRAAARRTAELLALPQVRHGAR
                     PLPADGRGRLELRGVTVARDGAPVLRGVDLAVPGGTTLAVVGHSGAGKSTLAAVAGRLT
                     DPDSGQVLLDGVPLAEADPAQLRREIGYAFERPALFGETVGAALAFGAERPAAPAVEAA
                     ARAAGADTFVRLLPRGYATPLADAPLSGGELQRLGVARAFAHAGRLLILDDATSSLDTV
                     TEHHVSRALLEDVRPGTRLLITHRLASAARADLVAWMDGGRIRAVAPHALLWQDADYRA
                     VFAGTAPEPSTAS"
     gene            14700..16583
                     /locus_tag="STRMOE7_RS03785"
                     /old_locus_tag="STRMOE7_03770"
     CDS             14700..16583
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017946994.1"
                     /locus_tag="STRMOE7_RS03785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_03770"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_084769554.1"
                     /transl_table=11
                     /translation="MTPVTVRLLPRALRFLRARTRVLLLMGGWSLLESAHTFLGGYSMA
                     KALDDGFLAGRTATGLTWLAVAAVAVVLGGLAGRGVFRGLAGLVEPLRDALVRAVVARA
                     LDEAVADPARAADTAVVSRLTNQTELARDSFAGLVLVARSFVFTAAGALLGLVSLAPQL
                     LLIVLPPLVAGLLLFVATLVPMARRQRAFLRADETLSAEFGAVAAGLRDVVACGAREEV
                     AARAHALIDAEERAARHLAGWAAARAVALGVAGQLPVLLLLVSTPWLLREHLTAGAVLG
                     ALTYLTQALLPALHTLMNALGSGGTRLLVVLDRLTRPARTPGRGPDGAGGPPTDVRLSH
                     ADGAPSVPAPAEDPDVRSAPGDHGAGDPRAARLPARSLRLSPEPLVGPRVELRAVTFAY
                     GPAAQPVLHDLALVVEPGEHLAVVGPSGIGKSTLTGLLAGLLHPVSGDVRVDGLPPGAA
                     YGSDPARLRVLIPQQAYVFSGTVRDNLLYLCPDGASTAALEATSHAVGLGPLLSRLGGL
                     DARIDPAALSQGERQLLALGRAHLSPAPLVLLDEATCHLDPAAEQRAERAFADRPGTLI
                     VIAHRISSARRADRILVLDGNRATVGSHTELLEHSALYRELAGNWQPERSH"
     gene            16786..18438
                     /locus_tag="STRMOE7_RS03790"
                     /old_locus_tag="STRMOE7_03775"
     CDS             16786..18438
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (96-262). E-value: 1e-17.
                     Score: 56.5. Matches aSDomain:
                     nrpspksdomains_STRMOE7_RS03790_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091023.1"
                     /locus_tag="STRMOE7_RS03790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_03775"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_084769556.1"
                     /sec_met_domain="PF00561 (E-value: 8.1e-21, bitscore: 73.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRISGPIAGRRKRAAAIAVTLSCYAALAGPGLGAADAPPTPSVPA
                     PALDWRPCPRDAHYDCAIAKVPLDYGDPHGRTLDLAVVRRKATRPGRRIGTLFFNPGGP
                     GGPGTVQMPQNYPLFPREVRERFDIVSWDPRGVGHSTAVNCFATAKENAAWLARRPSGF
                     PVGARQRKTWIAAYRELGRRCEQRDAALLRHVSTADSARDLDRLRRSVGDPKLTYLGAS
                     YGTILGATYANLFPGKVRALTLDSNIAPSAWTNHADDTPRLPTFLRMGSDRSAAATLDQ
                     FLTLCGSTTTANCAFSAGGPEATRDKFNRLMRRLRARPIGTWTYARTVADTVNGLYVVH
                     PGWTELAARLQGLWQGRAPAAPGPLPTPPVPVPYTGEEQAAAVLCGDSPNPRDPGVFRT
                     LEEASAARAGDAGRVWTWASEPCATWPTMAARRYTGPWNTPTAAPVLLVGTLYDPATPY
                     RNAQAMAKELANARLLTNNGYGHTALVNPSSCVNAYESRYFINGTLPPPGTTCRQDGAP
                     FPARQPRGGVDAGGGAMAVLISNRPRTGGPSTR"
     aSDomain        17074..17571
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STRMOE7_RS03790_Abhydrolase_1.1"
                     /evalue="1.00E-17"
                     /label="STRMOE7_RS03790_Abhydrolase_1.1"
                     /locus_tag="STRMOE7_RS03790"
                     /protein_end="262"
                     /protein_start="96"
                     /score="56.5"
                     /tool="antismash"
                     /translation="LFFNPGGPGGPGTVQMPQNYPLFPREVRERFDIVSWDPRGVGHST
                     AVNCFATAKENAAWLARRPSGFPVGARQRKTWIAAYRELGRRCEQRDAALLRHVSTADS
                     ARDLDRLRRSVGDPKLTYLGASYGTILGATYANLFPGKVRALTLDSNIAPSAWTNHADD
                     TPR"
     gene            18565..19392
                     /locus_tag="STRMOE7_RS03795"
                     /old_locus_tag="STRMOE7_03780"
     CDS             18565..19392
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (20-258). E-value:
                     5.2e-30. Score: 96.8. Matches aSDomain:
                     nrpspksdomains_STRMOE7_RS03795_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014059128.1"
                     /locus_tag="STRMOE7_RS03795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_03780"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_084769558.1"
                     /sec_met_domain="PF00561 (E-value: 2.4e-22, bitscore: 78.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.5e-22, bitscore:
                     80.1, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPYFEGADNTSLFYTDWGQGKPVVFVAGAWLSSSAWEFQMLPLSQ
                     QGLRCVAFDKRGHGRSDWVGHGFDYDTLADDLAALLDHLDLRDVTLVAHSMGGGEVIRY
                     LSRHGYDRISKVVLIAVTAPLMLHTPDNPEGIDRSLFDALSAERTKDRPRWMAQNAQAF
                     FATHLGNQVSSELIAWTVQRCLDCSAKAAVEVVETGFSTDLRKEAGTLQVPTLILHGDA
                     DASAPVHLTGRRLAQLVPDNVYKEYPGAGHGIFLTHTEQLNQDLLDFIEGSSS"
     aSDomain        18625..19338
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STRMOE7_RS03795_Abhydrolase_1.1"
                     /evalue="5.20E-30"
                     /label="STRMOE7_RS03795_Abhydrolase_1.1"
                     /locus_tag="STRMOE7_RS03795"
                     /protein_end="258"
                     /protein_start="20"
                     /score="96.8"
                     /tool="antismash"
                     /translation="KPVVFVAGAWLSSSAWEFQMLPLSQQGLRCVAFDKRGHGRSDWVG
                     HGFDYDTLADDLAALLDHLDLRDVTLVAHSMGGGEVIRYLSRHGYDRISKVVLIAVTAP
                     LMLHTPDNPEGIDRSLFDALSAERTKDRPRWMAQNAQAFFATHLGNQVSSELIAWTVQR
                     CLDCSAKAAVEVVETGFSTDLRKEAGTLQVPTLILHGDADASAPVHLTGRRLAQLVPDN
                     VYKEYPGAGHGIFLTH"
     gene            complement(19432..20187)
                     /locus_tag="STRMOE7_RS03800"
                     /old_locus_tag="STRMOE7_03785"
     CDS             complement(19432..20187)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="STRMOE7_RS03800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="STRMOE7_03785"
                     /product="uridine kinase"
                     /protein_id="WP_107487308.1"
                     /transl_table=11
                     /translation="MAELIDNEPSRYHDHGGRPTRDQVIGRIADHIADRRPGHPLRVAV
                     DGITAAGKTTLARALATAVGERGRAAIHLSMDGFHHPRAHRHRQGRDSALGYYQDAYDF
                     PAFARSVLVPLGPGGDHRYRSRIIDLASDQAIDEPPVTAPADAVLVVDGSFLQRHELAG
                     LWDEVVFADTSFGVARRRGTRRDSQLFGSTAAAEHAFDHRYHAACRRYLAEVDPAAHAT
                     IVVGNDDLDHPLLRRIDGEHTGTGHTPTT"
     gene            complement(20258..21088)
                     /locus_tag="STRMOE7_RS03805"
                     /old_locus_tag="STRMOE7_03790"
     CDS             complement(20258..21088)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018521953.1"
                     /locus_tag="STRMOE7_RS03805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_03790"
                     /product="MOSC N-terminal beta barrel domain-containing
                     protein"
                     /protein_id="WP_084769560.1"
                     /transl_table=11
                     /translation="MPTVSELITYPIKGCAGVPLAEAGLTPAGLPHDRSFMVVNNQGVY
                     RTQRRDPLLAVIRPEVSSDGGQLALHYRVVESLRIEVDTTSSRRDVDLFGAPFRGIDQG
                     AAAAGWLSEVLGTDCRLVRVPPEHDRVADGRIPGTSGYADSSPLHLLSLATFNDLNERL
                     AAAGKPPLPMSRFRPNIVLDGWQEPLTEDRVHRAEVGGAELGFAKLAIRCAVTLVDQET
                     GAKAGPEPLRTLASYRRVPEGGVAFGSKFSVVRTGKLTVGDEFTVTEWTAGGAC"
     misc_feature    21069..21087
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 16.82"
                     /tool="antismash"
     gene            complement(21174..21725)
                     /locus_tag="STRMOE7_RS03810"
                     /old_locus_tag="STRMOE7_03795"
     CDS             complement(21174..21725)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017946995.1"
                     /locus_tag="STRMOE7_RS03810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRMOE7_03795"
                     /product="response regulator transcription factor"
                     /protein_id="WP_084775995.1"
                     /transl_table=11
                     /translation="MRSALAALLRDEEQIDAVAACWRSAHGKARSFRPQVCVVDGDVAG
                     PMQDTSPPGGPDCGLLVLASACRPGTLRRAVAAKARGFVDKDAPPARLRHAINLVAAGQ
                     RYVDHTLSLDFLQAADMPLTPRELNVLQLAAGGASVPEIAHELHLSTGTVRNYMAAINR
                     KTGARNRVDAIRISQGAGWV"
     misc_feature    complement(21447..21449)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    21783..21795
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.58"
                     /tool="antismash"
     misc_feature    complement(21843..21857)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.94"
                     /tool="antismash"
ORIGIN
        1 tggcctgctg atacgcggcg gcggtcgcct cgggggtgcc gcacgtctgg ccgagcttgg
       61 tgccgccgta tccgccgacg gaggccgaca cgtcgccgcc cttggcgcgg accgtggcga
      121 tcacaccggc cacggcggtg tccgaggaca ccgggccggt cccgccccag gtcggcgaac
      181 agccgccgcc gttcggcgcc agcaggaagg cgagctggaa cgccttgagg ccggtcgcgt
      241 ccatgacggc tccggcgtcc ggcgggtcgt tgtcgagcgg catgaggtag ggcgccgcgg
      301 cgtaccagtt gctgcccacg gccttcgggg ccggggcggc ggcgccggga ccggtggcga
      361 gggccgtacc ggccgccacg agtgcgaggc aggcagccga ggcgacggcg gcgaaggttc
      421 tgacgtttcg aggtggcaca tgccctcccg cggggcgaaa gtggtccaga ccaatcgccc
      481 acagcctgac cgctcgtcgc gtacgcgtca acactttgga ctggaccagt ccacaggcgc
      541 aggcggagcc ggtgcggacg cgtccgcggc gcctcgcacg ccggaggggg gcgtggcaag
      601 gtggtgggtg aggttgcctc cctcgcccat ccgattccgc agaggaggcc cacatggacg
      661 acaaggagtt cttccgcgca gtggcggagc gctcgggact ctcccggcag gaagcggccg
      721 atctcacccg tgccaccctc gacacgctcg ggcaccggct gagcgccggc gaggctcgcg
      781 atctggccct cgaacttccc gagccgctgc gtggctcgct ccagtccgga cagggggaga
      841 tggagatctt cggtcccgac gaatcgatcc gcagggtggg cgagcacacc gggctgaccg
      901 agccggaagc cgcccggggc gtccgggcgg tcctcagcac cctgcaagag gccatctccc
      961 agaaggagtt cgcgcacgcc atgtcgcagc tcggcaagga gtacgcgcag ttggtggagt
     1021 ccacccgctg agcggatcgc cggcccggcc gggggaaccc ttccccggcc gggccggcgg
     1081 acgtcagcgt gccgcccgcc ggagggccgt cacgctcgac gggcgcccgc cgaggccatg
     1141 ccgagccagg tgtgcgggtt gccctgccag caccagccga gcttcggtgc cttctggctg
     1201 atccagatcg ccgggaccct gcggtcgccg ctccgcgaac cgcccagcga gaagcacttg
     1261 ttcttgacca gcacctccgg gaagtgggtg agcagcgcga tgccctcctc gatggtcagc
     1321 agggtgcggc cccgcccggc gagggtcgcc atggcttcgt gcggtaccgc accgcagaac
     1381 tcctcccccg ctcgacgtcg agcagcaggt aggcgtccgg ggccgggagc gcggtctcct
     1441 cggtggcgac gaaccgttcg agggcgccgg gctcgaagga gccgtcgatg aagccgggca
     1501 gccgcccgcc gtgcaggacg gtgcggggca tggtctcttc gacggggacc aggttccggg
     1561 tgacgaccag caggaacggc acccggccgg tctccggtgc gcaccggccg cccgccgcgg
     1621 cggccaccgc gtgcgcccgc aagggggcca gcagcgcgcc gaaccgctcc gggtcgaggc
     1681 cggacagcgc cgggtagtca cggtccgtca gattgcgtac ctggcggtcg aattcggcac
     1741 ccgcgtcgaa gggggtgggg gtcacgggca ttcctctcgt cgtggggaca ctcggccggc
     1801 cggcggtcgg ggaggcgctc accgggagac ctcgacggcg gccagggagc cggtctccag
     1861 ggcgcaccag acggcgcccc ggtacacggc gatgccgtgc ggttcgctgt ccgggcgggg
     1921 caggtcgtag ccggtgaacc ggccgtcggt ggtgaggcgc ccgacccggc cgctgcccca
     1981 ctcggtgaac cacagcgcgc cgtcggggcc ggtggtgagg gcgtgcggcc gtgcctggcg
     2041 gtcgggcagc gggtactcgg tgacggtgcc gtcgacggtg atccgcccga tctggcccgc
     2101 gccgatctcg gtgaaccaca gcgcgccgtc cgggcccgcg gtgatgccga ccggcgcggc
     2161 cccctcggtc ggcagcggga aggcggtcgt ccggccgtcc atggcgatcc ggccgatcac
     2221 atctgcctgg ttgagggtgc accacatggc gccgtcgggg cccgccacca gggcggacgg
     2281 gaaggctccg ggtgccgggt actcggtgaa ctcgccgctg gtggtgaggc gtccgatgcg
     2341 gtcggcggcg gacagcgtga accacagggc gccgtccggg ccgggcgcga tgccgaacgg
     2401 accgccgccg gcggtgggcg gctcgaaggc ggagacctcg ccgtcgacgg tgatccggcc
     2461 gatgcggtgc gtgccgtact cggtgaacca cagggcgccg tccgggccct gggtgatcac
     2521 cgtcgggccc gcgcccacgg ggtggacggt gaggtgcccg gccgcgtccc ggcggccgat
     2581 cgcgccctgg tggacgaggg tgaaccacag cgcgccgtcg ggcccctccg cgagcgcgta
     2641 cggacccgcg tccggcccgc tgacggtgtg gtcgcggacc gggtcggcga gccaccggcc
     2701 gatccggtcg agcagcacct cgcccaggtc ggacaggtgg aaggagtgcg gcgcgtcctc
     2761 ataggtgtcg aggcggacgc tcaccccggc ggcgtcggcg gcctcggcga agcggcgggc
     2821 gtcgtccagc aggacctcgt cggtgccgac ggcgaccagc agcggcggca gcccgcgcag
     2881 gtccccgtac agcggcgact gcggggcctg acgggggccg gcaccggcca ggtaccggtc
     2941 gctgacggcg gcgagaacgg cgcggtcgat caggtccttg ccgtcgttgg cggtcaggga
     3001 cgcaccggtc agggcgaggt cggtgacggg tgagaccgcg accgcggcac cggggagggg
     3061 gccgccggtg cgcttgatct ccagcagggc ggagagcacc agggtggcgc cggccgactc
     3121 gccgacgaac accacctccg aggccggcac gccggtctcc agcacaccgc gccaggcggc
     3181 cagtacgtcg tccagcgccg cggggtaggg atgcgcgggc gccagccggt aggcgacccg
     3241 cagcgccggc cgtccggtcg tccgcgacag ccggtaggcc atcatccgct cggcctcggg
     3301 ccaggtgtcc gtgaaaccgc cgccgtgtac gtagatcacc gcgccgcccc cggcgcccgg
     3361 cgcgcgcacc cagtcgccgc gcacctcggc gtcggccggg agcgggccgc tgaccagcgc
     3421 gccgatgcgg tcacggacgg cctgcgcctg cccgggcccg gcgggaacgg cagtgagagt
     3481 gagcaacggt cctccgtcat gggcgagttg cacccgtagg gaatttacgt cgagggtaaa
     3541 attacgtcag gggtagtggg gtgtcaagct aaaaatacta cgagggtaag attcgcccat
     3601 gggtatcgag tcgagcagta cgacggacgc cgcggcgccg ggcctgcggg cggccaagaa
     3661 gcgcgagacg cggcagctga tctccgaccg ggcgacccgg ctcttcgtcg agcagggctt
     3721 cgagcgcacc accatcgccg agatcgccga cgccgcccgc gtcgccaaga agacggtgac
     3781 gaactacttc ccgcgcaagg aggacctggc cctcgaccac caggacgcct tcgtcgccgg
     3841 cccggcccgg accgtggagg accgccggcc cggcgagtcc gccctcgcgg cactgcgccg
     3901 cgggttcctg tcggccgtca ccgcgcagga ccccgtcgcg ggattcgccg gaccggagtt
     3961 cacccgcatg atcgcggaga gccccaccct gaccgcctgt ctgcgcagcc tgcacgacca
     4021 gcgcgaggac gccctgacgg ccgcgctggc cgaggcgacc ggcgccgccc gtgacgacat
     4081 caccccgcgc accgccgcgg ccctgctggg cggggtgcac cggctcctgt tccggcgcat
     4141 ccaggaactc accctcgcgg gccgccccgg cccggagatc gccgccgtac tggcggagga
     4201 ggccgaccgg gcgttcgcgg tcctggaacc ggcgctcgcc gactacgccc gggcctgacc
     4261 accgctcccc ctacggcgcg tcggcggacc cgccgccgcg aggccgtcac ccggtcggcg
     4321 gagccggggc gggcaggagc cggtgccgtc cccgtgcggt ggggagggcc ccggccgggt
     4381 gccggtccgt ccccgcccgg cgcgcgtcct cgggccggaa ctggtctgct gggtcgggga
     4441 atcgccgtgc acccgggaga ggtccagatg agtgcctatc gagtcgcgca ggtcgccgcc
     4501 gcgggcgggt cgttcgagat cgtcgagcgg gaggtgccac ggccgggccc cggccaggtg
     4561 cggctggcgg tggaggcctg cgggatctgc cacagcgaca ccttcttcgt ccaggccgcg
     4621 ctgccgggcg tgcggttccc gctggtcccc gggcacgaga tcgccgggcg catcgacgag
     4681 atcggcgagg cgacgccggg cgactggcag gtgggcgacc gggtggtggt gggctggttc
     4741 ggcggcagct gccacgcctg cacgccctgc cgccggggcg acttcatcgt gtgcgagaac
     4801 ctgaaggtcc ccggctgggc gtacgacggc ggcttcggcg aggcggtgat cgcaccggcc
     4861 gacgccctgg cccgcatccc cgacgcggtc ccggccgccg acgcgggacc catggcctgc
     4921 gccggcgtga ccacgttcaa cggtctgcgg cgcagctccg cgcggccggg cgacctggtc
     4981 gccgtcctcg gcatcggcgg cctcggccac ctgggagtgc agtacgcggc cgccatgggc
     5041 ttcgaaaccg tggccctcgc ccgcggggcc gacaaggcgg acttcgcccg gcaactcggc
     5101 gcgcaccact acatcgacac cacggccgac acccccgtcg gtgacgccct gcaggcgctc
     5161 ggcggtgcca aggccgtcct ggccaccgcc gccaactcac aggccatcac cgcgacggtg
     5221 gacggactgt ccccgcgggg cgagctgatc gtcatcggcg cggacaccga acccctggga
     5281 atcagcccca accagctgct catgcagggc aaggtcgtcc gcggccatcc gtccggcacc
     5341 gcgcaggacg tgcaggagac catcgcgttc agtgccctgc acgggatccg cccgatgatc
     5401 gagaccatgc cgctcgaccg ggccgacgag gcgtaccgga agatgctctc cggcgccgcc
     5461 cgcttccgga tggtcctcac cacggactga cggccgcggc cgcggtgggt tgcctgcggc
     5521 ggtcggcgcg tcagccggtg cggcgtcctc cactccggtc agcgcggtac aggctgcgga
     5581 gaacaccgcc ggccgagacg gcaccccaac gccccggtcg cggctgcgag ttggccggtg
     5641 acgtcgaccg cggggcgggt cagtcggcgg tccggcgcag gatcagggtg acgaaacccc
     5701 aggtgtcccg gtagctccgc agccactcgg accgccgggt ggcggccatc gccagcgcct
     5761 ccgggccgtc cgggtcgccg gcatggtcca ggccccacgc ggcaagggtc ccccagcagg
     5821 cccactcgta ggcgtccagc tcctggcgcg tgctcacgtg cccgtggacg ggggtccagc
     5881 cgtcggcgac gacgcggtcc acggtggtcg cgaggtcggc gaagtcgccg agcatctcga
     5941 tggcctccgg cgacggcggg tgttcccaga acccgtcgcc gatcaggacg gcgccgccgg
     6001 gcgccaggtg cgcgcgggcc gcggcgagcg tgggcagcag accaccgaag gcgtgcgcgg
     6061 ccccgacgct gagcaccacg tcgaacgggt ccggggagac gaagtccgcg gccgctgcgt
     6121 ggtggaggac gaggcgctcc ccgacgccgc ggcggtcggc cgcctctcgc gcctgcgcca
     6181 gcgcgtcctc ggagatgtcc acgcctacgg cgtgcagttg cgggcgggcg gccagggcgc
     6241 gcagcagcca ttccgcgctg ccgcagccga ggtcgagcag ccgctcgtcg ccgcgtggcg
     6301 tgccgcgttc cagcagccgg cgcacggatt cgtcgtcgag cggagccttg atcgggtgcc
     6361 cggtgtgggc gatgcgggac atctgttcgc gattcaccgg cgcagcctgg cagcatcccc
     6421 ggtcgcgcgc atccggttat cgccgtgggc cacgctccac acccggttcc gctcgctcct
     6481 gatgtgggcg tgacatgtga cggcaaacct aggagcgggt ggcggtcgcg cagccgttgc
     6541 gggtgaccgt cgttccgtgg ctcgtgtcga tcggcctgct gcggtcgtac ggatcgaccc
     6601 ggtgggcctt gtcggcgggc tgctcgccgg ctgtgccgaa gggcggcacg aagtagccgg
     6661 tcggggcggc gcagccgccg ttggtcatgt cgagcgcgta cgagacgagg gacatcgtgc
     6721 ccggttcggt gatgaccttg gccgggtcgt cccagctcat caccaccttg cgccgcacga
     6781 tcgtacggac gacctcggcg tcccgcccgc cgtcgcctgc cggggtgacc gggtacacga
     6841 aggtgacgtc cgccgtcacc tcgaccgccc ctcgtttccc cttccggtac gcgagtcgac
     6901 cgcgcgtctt gatcacctca ccgaccagcc gggcctgctg cgtacggaag cggctgaaca
     6961 acagcagcgg gttggtctcg ggcgagggtg ccgtcgacga cagggcggta cggaggtact
     7021 cctggacgtc cttctggtgc gggttcaaca gcgcgatcgc cttcgtgggc cgctcgccgc
     7081 gcagcacacg ggagtcgagc cccgcggcca ccaggaagtc ccggctctgc cgcagtgccc
     7141 gctcgacctg ggcggcgtcc atccagccgg tcgcctcggc cggtggcacg gtgatccctg
     7201 ccgctccgtc agcccagtgg acggccggcg aaccccggaa gggttcggcg agggtggcgc
     7261 gcagagccgg ctcggcaccg ggcgcctccc gcggactttc cgactcggcg gccaacggtg
     7321 ccccgtcgcg cccgccgtcg gaaccaccga accagccgac gacctgctcc gggaagagcc
     7381 ccacgaccag gaggaccacg gccgccacca gcccggtcac gtaccagcct gtcctgcgcc
     7441 ggggccgggc cggtgcgtac gtacgccagc ccgtcgactc cccggaacgc tcccgcagcc
     7501 gccgctccac ctcacgggcg cgcgccgacg gctccacggg tgccccggcc gaacccgcca
     7561 ccgattcccg gaggaaccgc tcccactcct catcggacac ggacgacccg tcctgccccc
     7621 cagccccgct cacaccgcac tcccgttctc gctcgcatgc tcgatgcccg atggctcgat
     7681 cgccgcatga tcgcatgaac gagccgccgg cctgccgggg cggtggggga agcgtcaggc
     7741 cgccggaaag gccccggccc ctcggacaag ccctggttcc gcgaggagct tctcgacggc
     7801 cgtggccggt gccttcgggt gcagtgcctc ggtgcggtgt acgagccggg gcgcgctcac
     7861 cggtacggcg accgttcccg gcaggccgtc ggcggccgtg gaggggagcg cggcgaggcc
     7921 gttcccgccc gcgacgagcg ccccgagtgc gcgcaagtcc gttccctcgt aggtggcgtg
     7981 ggcccggaag ccgtccgtgt gggcggccgc ccgcagccgg ccgaggggta ccgcggcgtc
     8041 gggggcgtcc agccagtggg cgtcggcgag gtccgccagc cgcaggccgc ggcggcccgc
     8101 cagcgggtgg ccggacggca gcaggatgac gaggggttgc tcgcccaccg cgagggtggt
     8161 cagggtcccg gtgtccggca gcggcagcgg gtcgctgggc gcggtgaccc cgtcgacgag
     8221 ggccaggtcc gcgtccccgg tcagcaccgc ccgcagcacg gcctcccggc cgcggacccg
     8281 gacggtgacg gcgaggccgg gcagggcctg ccggatccgg gccagcgcgc cggcccagtc
     8341 gggggtgagc gcggccggac cgcagtcgac ggcgaggcgg gcgggccgca cgtcccgcag
     8401 cctggcgagg tcggcgcggg ccgcgtcgag gcgcagcagc agcggccggg cgtgttcgag
     8461 gaggcgccgg cccgcctcgg tcgcggcgac cggccggcgt cccaccagcc gcgtaccgag
     8521 gtcggcttcg agggcggcga tgtgctggga gacggcggac tgggtgtagc cgaggtcctg
     8581 ggccgcggcg gagaacgacc ggtgctcgac caccgcgacg aaggtgcgca ggaggtgcgg
     8641 atccatgcgc agcagtatcg cctgatcatc agcgttgctt atgcagggtc cgcagatcat
     8701 cgttggacct gatgggccgt cgccgcacac gatggggcca tggcacctca cgcacggatc
     8761 gccctggtgg gcgaccgctc cccgaacgtc cgctcccacc tccgcgtccc cgtacttctg
     8821 gacgccctgc gccaccgcga cgggctcgac ctggacgcgt actggatccc caccgaggag
     8881 gccgaggagg ggatcgcggg cttcgacgcg gtctgggtgc tgccggggag tccgtaccgc
     8941 agcgagtcgg gtgcgctcgc cgccgtccgc gcggtccggg aaggccaggt ccccttcctc
     9001 ggcacctgcg gcggcttcca gcacgccctg ctcgaatacg cccggaacgt gtgcggactg
     9061 caccgggcgg accacgccga gaacagcccg ggggccgacc tcgggtcggc cgtcatcgtc
     9121 ccgctcgcct gctcgctggt cgggcacgag ggcgcgatcc ggctcactcc cggctcccgg
     9181 gccgcccaac tcctcggcgc ggagcgcacg gtggagcgct accactgcaa ctacggtccc
     9241 aacccggccc acctggacac cctgcgcgcc cacggcctgc gcttcaccgg gaccgacgag
     9301 gccggagacg tccggatcgc cgagcttccc ggccatccgt tcttcctcac caccctgttc
     9361 cagcccgagc tccacggcga cggcacccgg ccgcacccac tggtcaccgg actcgcgagg
     9421 gcggccgtcc ggcacgccgc ggaggccggg tgaccggcgt cctccggggc ggacacggac
     9481 cggcgcaccg agcgggtttg cgcggtattg cgccgggcag gcggatcttt gtcaaggaac
     9541 ggctcgacag caagggagca cgaccatgac cgccgagaag aagacgtccg ccaaggccga
     9601 ccagctcaag ggcgccgtga aggaaaccct cgggcgcgcg gtgggcaacg agcggatgac
     9661 cgccgaagga cgcgcggagc gcgccatggg cgatatgcgg gaagccggcc acaaggccaa
     9721 ggacgccctg aagcgatgag ggcaccccgc agccacttcg gcagatgcgg ccgcgcatgc
     9781 agagactgag gcgatggccc ggcggatcct cccgccgggc catcgccgtg tccgccccgg
     9841 ccccggcgcg caccgacggc gcaccgtcgc ggcggcccct gcggagcccc ctgcccgtca
     9901 cgtaaaacgt gcattcctca cgacctcgtc gtgacactca tgactgtttc ccccctccgc
     9961 gccgtgacag cgtggtgatg tcaccggccg aaggagtggg atgaacaagg ggtacgcggt
    10021 cttctgcgac gcagaccggc agttctacga cgctccgcac cgcttcccct cggacgaaga
    10081 gggccgcggc gccctgtacc ccgtactgcg ccgggagttg cccgacggct ggcagcgcca
    10141 ccggtcgggt gactggctgg ccttccgccc gctggatcgt gaactcccca gccagggctg
    10201 gaaaattcat gtctccgcct gcctggacaa cgccgagcgg atcctggaga aggtctggga
    10261 ctactgcgtc ccccgctcgg tggcgttcaa gtgcatgccg agccgctatc tgctgcacat
    10321 acgcaacgcc aagtacaccg accggggcgc cagcgggaag ttcgtcaccg tctacccggc
    10381 cgacgcggag cagtgccgcg tcatcgccga ggagctggac gccctgctgg ccggcgagcc
    10441 cggtccgtac atcctcagcg atctgcgctg gggcgccggc ccggtgtacg tgcgctacgg
    10501 cagcttcacc gagcggcact gctacgacga caagggcgag ctctgccccg cgatcgagga
    10561 cgaccggggg cgactggtcc ccgaccgccg ggagcccgcc ttccgggtcc cggagtgggt
    10621 cgacctcccg gacttcctca agccccacct ggacgcacgc tccgccacga cggtcaccga
    10681 cctgccgtac gcgatagagc gggcactgca cttctccaac ggcggcggcg tctacgtcgg
    10741 ccgggacctg cggaccgagc gccgggtggt gctcaaggag gggcgtccgc acgccgggct
    10801 ggccgcggac ggcgcggacg ccgtggcacg gctggagcgt gaacgggacg cgctgcggcg
    10861 gctgtccggg ctgggctgcg cccccgaggt gctggactgg ttcacgctcg gggagcacac
    10921 cttcctggtg ctggagtaca tcgagggccg gccgctcaac agcttcttcg cgcaccgcca
    10981 tccgctgatc gaggccgatc cgtccccgga gcggctggcc gagtacaccc ggtgggcgct
    11041 gcgtgtgcac cggctcgtgg aggaggccgt cgagacgatc cacgcgcggg gcgtggtctt
    11101 caacgacctg catctgttca acatcatgct ctccgaggac gaatcctcgg tggtcctgct
    11161 ggacttcgaa gccgcctccg tcgacgaccc cggcagccgg caggtgatcg ccaaccccgg
    11221 cttcgtcgcc cccgccgacc ggcgcggcgc ggacgtcgac cgttacgccc tggcctgtct
    11281 gcggctggcc ctgttcctgc cgctgaccag cctgttcgcg gtggaccggc acaaggcccg
    11341 gcatctggca cggatcgccg cggagcagtt tccggtgccg cgggagttcc tcgacgcggc
    11401 ggtcacggag atcctgcgcg gccaccccgt cccgcacaca ccggcacccg cgcaacagcc
    11461 gtccgccgac gcctacttac ccgtcaagct cgccgactgg ccccacagca gggacagtgc
    11521 ggtccgggcc gtgctcgcct cggccacccc cgagcgggag gaccggctct tccccggtga
    11581 catcgcccag ttcgccacgg cgggcggggg gacctgcttc gcctacggcg cggccggtgt
    11641 cctgtacgcg ctcgccgcga ccggcgccga gcgatgtccc gacgccgagg aatggctgct
    11701 gcaacggacg aagagccccg cgtcgggcag cccgctgggc ttctacgacg ggctctccgg
    11761 tgtggcgtgg gtcctcgacc ggctcgggca ccgcgaacgg gccctggacc tcgtcgatct
    11821 cgtcaccgcg cagagctggc aggacatcgc acccgacctg cacagcggac tggccggggt
    11881 gggtctggcg ctggacgagc tggccgggtc caccggggag agcgccgcgc gggaccaggc
    11941 gctgcgctgc gcggagctgg tcgcccaccg cctccgctcc gcgccgccgc ccaccgcgcc
    12001 cgccgacggg accgcggcgc cgtcccgcgc cgggctgctg cacggcgaca gcggagccgc
    12061 gctgctcttc ctgcggctgt acgaacgcac cggcgacggc gcgctgctgg acctggccgc
    12121 cgaggcgctg cgccgcgacc tggcccggtg cgtacggagc gcgggcggca ccctgcaggt
    12181 caacgagggc tggcggacca tgccctacct cggcgccggc agcgtgggca tcggcatggt
    12241 gctcgacgac tacctcgccc accggccgga cgacgcgttc gcggcggcgc gggacgagat
    12301 cgtcaaggcc gcccaggcca agttctacgc ccagcccggc ctgttccgcg gtgcggccgg
    12361 catggtgctg tacctgagcc gtaccaccgc caccggcccg ggcaccgacg ccgccgacct
    12421 ccaccgccag atcgagtccc tctcctgggg cgccgtcccc taccaaggac atctggcctt
    12481 cgccggggag cagatgatgc ggctctccat ggacctgagc accggcaccg ccggatgcct
    12541 gctcgccctg ggcagcgcgc tgcacgactc acccgtgcac ctgcccttcc tcccgccgct
    12601 gcggcggccc tgaagccggc ccctcccggg gccgtacaag aaaagcactc ccgtcccctt
    12661 acgaaaggaa tcatcatgtc gcttctcgac ctgcagacga tggagacccc gaagcccgag
    12721 ggcaccgagg agctgcacac cggcagccgc gcgagcctcc tcctctgcgg tgacagcagc
    12781 ctgagcgtca ccacctgtaa ctgaccgcct gccgcagcgg ggcccccagt cccgcaacgg
    12841 cacggtgaga cgggccccgc gcagcaccgg ctgcgcgggg ccctccgccc cgccgcgccg
    12901 caccgttcga cccacggagg cgaggtccac cgcatgcccg ccccatccgg gcccccctca
    12961 ccgacgcgcc cgccggccac cggccggaag ccggaccccg gtgccgccgt cctgaccgac
    13021 gccttccggc acagccccgt gcacaccgtc gcggtgtgcc tcttcggcgt ggccggtgcc
    13081 gctgtggccc tcgccctgcc ggccgtcctc ggccacaccc tcgacctcct gctcgactcc
    13141 gcgcccggcg tcggcgccgc cctcatgctc agtgccgtcc tgctggtggc ggacgttctg
    13201 ctggacgccc tggtggcgct cgccggcggc gtcaccaccg cgcgcagcac cgcctggctg
    13261 cgccggcgcg gcatcggcca tctgctgtcg ctggccccgc accgcgccgc cgaccgcttc
    13321 accgccggcg acctggtgac ccggctgacc ggcaacgccg cggaggccgg gaccgcgccc
    13381 accaccgccg ccaccggcct ggccgcggtg ctcaccccgg tgggggcact ggtggcgctg
    13441 gcggtcaccg acgtctggct ggcggccgtc ttcctcgccg gtctgcccct cctgacccgt
    13501 ctgctgcgga ccttcgccca gggctcctcc gactgcgtac ggcgctatca gcgcgtccag
    13561 gcggagatcg cctcccggct cgtcgaggcg ctcggcgggg cccggacgat cgccgccgcg
    13621 ggcaccgggg cacgggaacg cgcccgcgtg ctggcgccgc tgcccgaact cgacgcgcac
    13681 ggccggctca tgtggcaggt ctacgggcgg gcggtcgtcg gcagcagcat cctggtgccg
    13741 ctgctgacca ccgtggtcct cgcggtgggc gggctccggc tcgcccacgg cgccctcacc
    13801 gtgggcgagt tgctggcggc ctcccggtac gccgcgctca ccgcggcgct gggcggcgtg
    13861 accggccagc tcaacgcctt ggtacggggc cgcgccgcgg cccgccgcac cgccgaactg
    13921 ctcgccctgc cgcaggtccg ccacggcgcc cgaccgctgc ccgccgacgg gcgggggcga
    13981 ctcgaactgc gcggggtgac cgtcgcccgc gacggcgccc cggtgctgcg cggcgtggac
    14041 ctggcggtgc ccggcgggac gaccctggcg gtggtcggcc actccggcgc cggcaagtcc
    14101 acgctggccg ccgtcgcggg acggctcacc gatcccgaca gcggacaggt gctgctggac
    14161 ggggtcccgc tcgcggaggc cgacccggcc cagctgcgcc gggagatcgg ctacgccttc
    14221 gagcggcctg cgctcttcgg cgagaccgtg ggcgctgccc tcgccttcgg ggcggaacgg
    14281 cccgccgccc ccgccgtcga ggccgcggcg cgcgcggccg gcgccgacac cttcgtacgc
    14341 ctgctgccgc gcggctacgc cacgcccctg gccgacgccc cgctgtccgg cggcgagctg
    14401 caacgcctgg gcgtggcacg ggcgttcgcg cacgcggggc ggctgctcat cctcgacgac
    14461 gccacctcca gtctggacac cgtcaccgaa caccacgtca gccgggcgct gctggaggac
    14521 gtccggccgg gcacccgcct gctgatcacc caccgcctcg cctcggccgc ccgcgccgac
    14581 ctggtcgcct ggatggacgg cggccggatc cgcgcggtcg ctccgcacgc gctgctgtgg
    14641 caggacgccg actaccgcgc ggtgttcgcc gggaccgcgc cggaaccgag taccgcctca
    14701 tgacgccggt cacggtccgg ctgctgccgc gggcgctccg cttcctgcgg gcgcgcaccc
    14761 gcgtcctgct gctgatgggc ggctggtccc tgctggagtc ggcccacacc ttcctcggcg
    14821 gctacagcat ggccaaggcc ctggacgacg ggttcctcgc cggccggacc gccaccggtc
    14881 tgacctggct ggccgtcgcc gcggtggccg tcgtcctcgg cggtctggcc gggcggggcg
    14941 tcttccgcgg actggccggc ctggtcgagc cgctgcgtga cgccctggtc cgtgcggtgg
    15001 tggcccgggc gctggacgag gcggtcgcgg acccggcccg cgcggccgac accgcggtgg
    15061 tctcccggct gaccaatcag acggaactgg cgcgggacag cttcgccggg ctggtcctgg
    15121 tggcccgttc gttcgtcttc accgcggccg gggcgctgct cggactggtg tcgctggccc
    15181 cgcagttgct gctgatcgtg ctgccgccgc tggtcgccgg gctgctgctg ttcgtggcga
    15241 ccctggtgcc gatggcccgg cggcagcgtg ccttcctgcg cgccgacgag acgctgtcgg
    15301 cggagttcgg cgcggtggcg gcggggctgc gcgacgtggt cgcctgcggg gcgcgggaag
    15361 aggtggcggc gcgcgcacac gccctgatcg acgccgagga gcgggccgcc cggcacctcg
    15421 cgggctgggc cgccgcccgg gccgtcgcgc tcggcgtcgc cgggcagctg ccggtcctcc
    15481 tgctgctggt cagcaccccg tggttgctgc gcgagcacct caccgccggt gccgtcctcg
    15541 gtgcgctgac ctatctgacc caggccctgc tgccggccct gcacacgctg atgaacgctc
    15601 tcggctccgg cggcacccgg ctgctggtcg tactggaccg gctgacccgg cccgcgcgga
    15661 caccggggcg cgggccggac ggggcgggcg gaccgcccac cgatgtccgg ctgtcacatg
    15721 cggacggcgc cccgtccgtc ccggcaccgg ccgaagatcc ggacgtccgc tccgcgcccg
    15781 gcgaccacgg cgccggggac ccgcgcgccg cccggctccc ggcccgttcc ctgcgcctgt
    15841 cccccgagcc tctcgtgggc ccccgcgtcg aactgcgggc ggtcaccttc gcctacgggc
    15901 ccgccgcgca accggttctc cacgacctcg ctctggtcgt cgagccgggc gaacacctcg
    15961 ccgtcgtcgg cccgagcggc atcggcaagt ccaccctgac cggtctcctc gccggcctgc
    16021 tgcaccccgt cagcggcgac gtccgggtgg acggactgcc accgggggcg gcgtacgggt
    16081 ccgaccccgc ccggctccgg gtcctcatcc cgcagcaggc gtacgtcttc tccgggaccg
    16141 tgcgcgacaa tctgctctac ctgtgccccg acggggcgtc gacggccgcc ctggaggcga
    16201 cgtcgcacgc ggtcgggctg ggcccgttgc tctcccgtct gggagggctg gacgcccgga
    16261 tcgacccggc ggcgctgtcc cagggcgaac gccagctcct cgccctcggc cgggcccacc
    16321 tctcccccgc cccgctcgtc ctcctcgacg aggccacctg ccacctcgac cccgcggcgg
    16381 agcagcgcgc cgagcgggcc ttcgccgacc ggcccggcac gctgatcgtc atcgcccacc
    16441 ggatcagctc cgcccggcgg gccgaccgga tcctcgtgct ggacggaaac cgggccaccg
    16501 tcggcagtca caccgagctg ctcgaacact cggccctcta ccgcgaactc gccggcaact
    16561 ggcagccgga gcgctcccac tgaccggtac ccgcggaaac gggcggcact gacatgacgc
    16621 tcctcgcagg caggggcggc accggttcag ccgtccggag cccggctcag ccgttcggcc
    16681 ccggccggtc gcgcccggtg ccgcggcgcg gtggggtggg cacgggtgcc gtcggcatcc
    16741 gatacccggg tgccgacggg tgctcggccc gtgggaggac gacgcatgcg catatccgga
    16801 ccgatagcgg gccgccggaa gcgggccgcg gccatcgccg tgacgctgag ctgctacgcg
    16861 gcactggccg ggccgggcct cggcgcggcg gacgccccac cgacgccttc ggtgcccgcc
    16921 ccggcactgg actggcggcc ctgccctcgg gacgcgcact acgactgcgc gatcgcgaag
    16981 gttccgctgg actacggcga cccccacgga cgcaccctcg acctggcggt cgtacgacgc
    17041 aaggcgaccc ggcccggacg gcgcatcggc accctgttct tcaaccccgg cggccccggc
    17101 gggccgggaa cggtccagat gccgcagaac tacccgctgt tcccgcgcga ggtgcgggag
    17161 cggttcgaca tcgtcagctg ggacccgcgc ggggtcggcc acagcaccgc cgtgaactgc
    17221 tttgccaccg ccaaggagaa cgccgcctgg ctcgcccgca gacccagcgg cttcccggtc
    17281 ggcgcgcggc agcggaagac ctggatcgcc gcgtaccggg agctgggccg gcgctgcgag
    17341 cagcgcgacg ccgcgctgct gcgtcacgtg tcgaccgccg actccgctcg cgacctcgac
    17401 cggctccgcc ggtcggtggg cgaccccaaa ctcacctacc tgggcgcctc ctacggcacc
    17461 atcctcggcg ccacctacgc caacctcttc cccggcaagg tccgcgccct gacgctcgac
    17521 agcaacatcg ccccgtcggc ctggacgaac cacgccgacg acaccccccg gctcccgacc
    17581 ttcctgcgga tgggctcgga ccgctccgcg gcggcgaccc tggaccagtt cctcaccctg
    17641 tgcggatcca ccaccacggc gaactgtgcc ttctcggccg gcggcccgga ggcgacccgg
    17701 gacaagttca accggctgat gcgccgcctc cgtgcgcggc cgatcggcac ctggacctac
    17761 gccaggacgg tggcggacac cgtcaacggc ctctacgtcg tccaccccgg ctggaccgaa
    17821 ctcgccgccc ggctccaagg actgtggcag ggccgcgccc ccgcggcgcc cgggccactg
    17881 cccacacccc cggtcccggt cccgtacacc ggcgaggagc aggccgccgc cgtcctctgc
    17941 ggtgacagcc ccaacccgcg cgatcccggc gtcttccgca ccctggagga ggcgagcgcc
    18001 gcccgtgcgg gcgacgccgg acgcgtctgg acctgggcct cggagccgtg cgccacgtgg
    18061 cccaccatgg ccgcccgccg ctatacgggc ccgtggaaca caccgacagc ggcccccgtc
    18121 ctgctggtcg gcaccctcta cgaccccgcc acgccctacc ggaacgcgca ggccatggcc
    18181 aaggagctgg ccaacgcccg cctgctcacc aacaacgggt acggacacac cgcactggtc
    18241 aaccccagca gctgcgtcaa cgcgtacgaa agccggtact tcatcaacgg cacccttccg
    18301 ccgccgggaa cgacgtgccg gcaggacggg gcgcccttcc cggcccgtca gccgcgcggc
    18361 ggcgtcgacg ccggcggcgg cgcgatggcc gtgctcatct cgaaccggcc ccggaccggc
    18421 ggcccgagca cgcgctgacg acccgcccgc cgggttcggg ctccacggtt acctgtggag
    18481 taatcgacgg tgtgctgccc cttggacgag agttgtcggc acagcgacac cgcgacaccg
    18541 caccgtccag gaagggaccc gcacatgccg tacttcgaag gcgccgacaa cacaagcctg
    18601 ttctacaccg actggggcca gggcaagccc gtggtgttcg tggccggagc ctggctcagc
    18661 agcagcgcat gggagttcca gatgctgccg ctgtcccaac agggcctgcg ctgcgtcgcc
    18721 ttcgacaagc gcggccacgg ccgctcggac tgggtcgggc acggcttcga ctacgacacc
    18781 ctcgccgatg acctcgccgc cctcctcgac cacctcgacc tgcgcgacgt caccctggtc
    18841 gcgcactcga tgggcggcgg cgaggtcatc cgctacctct cccggcacgg ctacgaccgc
    18901 atcagcaagg tggtcctgat cgccgtcacc gccccactga tgctccacac ccccgacaac
    18961 ccggaaggca tcgaccgaag cctcttcgac gccctgagcg ccgagcggac caaggaccgc
    19021 ccgcggtgga tggcccagaa cgcccaggcc ttcttcgcca cccatctggg caaccaggtc
    19081 tccagcgaac tcatcgcctg gacggtacaa agatgcctcg actgctcggc caaagcagcc
    19141 gtcgaggtcg tcgagaccgg cttctccacc gacctgcgca aggaagcagg caccctccag
    19201 gtgcccacac tcatcctcca cggcgacgcc gacgcctccg cccccgtcca cctcaccgga
    19261 cgccgcctgg cacaactcgt acccgacaac gtctacaagg agtaccccgg agcgggacac
    19321 ggcatcttcc tcacccacac cgagcaactc aaccaggacc tgctcgactt catcgagggc
    19381 tcgtcgtcct gaagggtgct cgtggctgag ggccgcgcac cctcaccggc gtcacgtcgt
    19441 gggggtgtgg cccgtgccgg tgtgctcgcc gtcgatccgt cgcagcaggg ggtgatcgag
    19501 gtcgtcgttg ccgacaacga tggtcgcgtg cgcggccggg tcgacctcgg ccaggtagcg
    19561 ccggcaggcg gcgtggtagc ggtggtcgaa ggcgtgctcg gccgctgcgg tgctgccgaa
    19621 cagctgggag tcgcggcggg tgccgcgtcg gcgggcgacg ccgaagctgg tgtcggcgaa
    19681 cacgacctcg tcccacagtc cggccagttc gtgccgctgc aggaagctgc cgtcgaccac
    19741 caggaccgcg tcggcggggg cggtgaccgg cggctcgtcg atcgcctggt cgcttgccag
    19801 gtcgatgatg cggctgcggt agcggtgatc gccgccgggt ccgaggggaa cgaggacgga
    19861 ccgcgcgaac gcggggaagt cgtaggcgtc ctggtagtaa ccgagcgcgg agtcgcggcc
    19921 ttgccggtga cggtgggcgc gcgggtggtg gaacccgtcc atggacaggt ggatcgccgc
    19981 tcggccccgc tcgcccaccg cggtggcgag ggcgcgggcg agagtggtct ttccagcggc
    20041 ggtgatgccg tccaccgcaa cccgcagcgg gtgccctggc cgccggtcgg caatatggtc
    20101 ggcgatgcga ccgatgacct ggtcccgggt gggtcggccg ccgtggtcgt ggtaccggct
    20161 cggctcgttg tcgatcagtt ctgccatggg gcggatccta gtgacctcgc tgctgcgcgc
    20221 ctcgctttcg ctctgccccg gcgcacgctc ggcgcggtca acaggccccg ccggccgtcc
    20281 attccgtgac ggtgaactca tcgcccaccg tcagcttccc ggtccgtacg acggagaact
    20341 tcgagccgaa ggccacaccg ccctcgggca cccgtcgata ggaggcgagt gtccgcagcg
    20401 gctccggccc ggccttggcg ccggtctcct ggtcgaccag ggtgacggcg cagcgaatgg
    20461 cgagcttggc gaaccccagc tcggcgccgc ccacctcggc ccggtgcacc cggtcctccg
    20521 tgagcggctc ctgccacccg tccagcacga tgttgggccg gaaccgggac atcggcaacg
    20581 gcggtttccc cgctgctgcc agccgctcgt tgaggtcgtt gaaggtggcc agggaaagga
    20641 ggtgcagcgg gctgctgtcg gcgtaacccg aggtgcccgg gatgcggccg tcggccaccc
    20701 ggtcgtgctc cggcggtacg cgcaccagtc ggcagtccgt accgagcacc tcggacagcc
    20761 agccggctgc cgccgcaccc tggtcgatgc cgcggaacgg tgcgccgaag aggtcgacgt
    20821 ccctccggga cgaggtggtg tccacctcga tgcgcaagga ttcaacgacc ctgtaatgca
    20881 aggcaagttg gccgccatcg gagctgacct cgggccggat caccgccagc agcggatctc
    20941 tgcgctgggt gcggtaaacg ccctgattgt tgacgaccat gaagctgcgg tcgtgcggga
    21001 gtcctgccgg agtgaggccg gcctccgcca gcgggacccc tgcgcacccc ttgatggggt
    21061 aggtgatcag ttcggaaact gtaggcatgt gagcacctta tggacgcctc gccacccgca
    21121 tgacgcgctt tcgtcacttg cggcggagca ctcggcactg tttgagacag cccctagacc
    21181 cagccggccc cctgcgagat gcgtatggcg tcgacccggt tgcgggcgcc ggtcttacgg
    21241 ttgatcgccg ccatgtagtt gcgcactgtc cccgtgctca gatgcagttc atgggctatc
    21301 tcgggtacgg acgccccgcc cgcggcgagt tgcagcacgt tcaactcgcg tggcgtgagc
    21361 ggcatatcgg cggcctggag gaagtccagg ctcagcgtgt ggtcgacgta gcgctggccg
    21421 gccgcgacca ggtttatggc gtgtcgtaac cgggccggcg gcgcgtcctt gtcgacgaat
    21481 ccacgggcct tggcggcgac ggcccgccgg agcgtgccgg gccggcaggc gctcgccagg
    21541 acgagcaggc cgcagtcggg cccgcctgga gggctggtgt cctgcatcgg tcccgccaca
    21601 tcgccgtcca ccacacacac ctggggccgg aaggaacgcg ctttcccatg ggcgctccgc
    21661 cagcaggccg cgaccgcgtc gatctgctcc tcgtcacgca gaagcgcggc cagcgccgat
    21721 cgcatcagcc gtgtctcatg gaccaccagg acccggatca cactcgcccc ttcaagtcgg
    21781 ccatgcggtt tgcactgctg aattgtcatc gtccgcattc ccgccagtcg aaccttcacc
    21841 ggaattgact ggaaaacacg cccccttgtc acactgacat tgcgtccatt gcggtggcgt
    21901 atgacaggag cccacaactc gtcgcacatc cggcggtcac cggccggcgc gtcagctgcc
    21961 gccgttggcg ccctaccacg cgcgcgacgt cgcaccccag cgccctccct cgcctcgcgg
    22021 cctacttcgc ggtagcgaag tcgtaggaac ctcacacacg gcgggccact gtttccggca
    22081 gccgcacggc gccagggaca acgacttccc gccatcatca acgtggccac ttaccacgcc
    22141 cgttcgccga ctgggcaatc tggcggtgct gccgtgaccg ctgtgtccga tgagatgcgg
    22201 gcggcacacg cggtacgtgg tgcgaaagtc cagcccagga gggcggtcca cccggcacgg
    22261 ccgccatgcc cggcggcccg cacaggcttc cctatgctgc cgaccgctcc tcagcgctcg
    22321 cttccgaacc ggctcccgcg gtgcggacgg cgccgacggc ggcgagggcc accgcgagca
    22381 ctcccgccca ctgcggcgcg gcgaggtgct gcccgaggag gagcaggccg acgagggcgc
    22441 cgacggcggg ttcgaggctg gtcaggacgc cgaagacgcg gggtggcaga cgacggaggg
    22501 cttcgaggtg gcaggtgtag ggcagcacgc tggagaggac ggcgacgacg acggccggcg
    22561 cgagcgtgcc ggggtccagc agccgggccc ccgcccgcgc gatcccgtac ggg
//
