LOCUS       NZ_CP020557            25504 bp    DNA     circular CON 24-JUL-2024
DEFINITION  Paenibacillus larvae subsp. pulvifaciens strain SAG 10367
            chromosome, complete genome.
ACCESSION   NZ_CP020557
VERSION     NZ_CP020557.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus larvae subsp. pulvifaciens
  ORGANISM  Paenibacillus larvae subsp. pulvifaciens
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 4666454)
  AUTHORS   Dingman,D.W.
  TITLE     Paenibacillus larvae genome sequencing
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4666454)
  AUTHORS   Dingman,D.W.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-MAR-2017) Entomology, CT Agric Expt Station, 123
            Huntington St, New Haven, CT 06504, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: FEB-2016
            Assembly Method :: SMRT Pipe HGAP assembly v. February-2016
            Assembly Name                     :: sag10367-hgap-022916
            Genome Coverage                   :: 214.2x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002082155.1-RS_2024_07_24
            Annotation Date                   :: 07/24/2024 02:27:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,275
            CDSs (total)                      :: 5,166
            Genes (coding)                    :: 4,634
            CDSs (with protein)               :: 4,634
            Genes (RNA)                       :: 109
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 532
            CDSs (without protein)            :: 532
            Pseudo Genes (ambiguous residues) :: 0 of 532
            Pseudo Genes (frameshifted)       :: 400 of 532
            Pseudo Genes (incomplete)         :: 184 of 532
            Pseudo Genes (internal stop)      :: 26 of 532
            Pseudo Genes (multiple problems)  :: 72 of 532
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:07:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4276650
            Orig. end                         :: 4302154
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP020557.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Dr. Adriana Alippi,
            CIDEFI-CIC, Facultad de Ciencias Agrarias y Forestales, Universidad
            Nacional de La Plata, 1900 La Plata, Argentina.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25504
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /product="azole-containing-RiPP"
                     /region_number="20"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..25504
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="interleaved"
                     /product="RRE-containing"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..21951
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11951](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11951
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    complement(154..168)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.07"
                     /tool="antismash"
     gene            260..688
                     /locus_tag="B7C51_RS22950"
                     /old_locus_tag="B7C51_22945"
     CDS             260..688
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003350989.1"
                     /locus_tag="B7C51_RS22950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22945"
                     /product="cell wall hydrolase"
                     /protein_id="WP_023484628.1"
                     /transl_table=11
                     /translation="MAVVKASSSDIDLLARLLRAEAEGEGEQGMLLVGNVAINRVRADC
                     SDFKDIRTIPQMVFQPHAFEATLYGYFYQKARDRERRLARRSINGERHWPAKFSLWYFR
                     PPGECPPTWYNQPLVGRYKKHCFFEPTAETCEDVYSTF"
     gene            complement(752..1944)
                     /locus_tag="B7C51_RS22955"
                     /old_locus_tag="B7C51_22950"
                     /pseudo=""
     CDS             complement(752..1944)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020155178.1"
                     /locus_tag="B7C51_RS22955"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22950"
                     /product="oxalate decarboxylase family bicupin"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKNPSYPHDVNIPQPIRDDGAGATDTGPRDVMRDLENPDMLVPPY
                     TDAGTIPNMKFSFSDTHMQLSHGGWSREVTVRELPIATTLAGVNMRLTPGGVRELHWHK
                     QAEWAFMISGCARVTAVDQNGRNFIADVEMGDLWYFPPGIPHSIQGLKEGCEFLLVFDD
                     GNFSEFDTFSISDWFAHTPKDVLAANFGIPESALAQIPDKQIYMYQGQVPGPLETQKVP
                     DSNGTVPKSFTHRLFAQNPIRTPGDRFALSILLISPLQQLSRPL"
     protocluster    1948..25504
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[11947:15504](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      11948..15504
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="2"
     gene            complement(2160..2708)
                     /locus_tag="B7C51_RS22960"
                     /old_locus_tag="B7C51_22955"
     CDS             complement(2160..2708)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012792.4"
                     /locus_tag="B7C51_RS22960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22955"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_079940710.1"
                     /transl_table=11
                     /translation="MNSNYNIKYKLLSEKDLTKELLDHFNRFQEVKNVWRIIDNKKALI
                     EHPFVEQWSSEEKSNLITGHFTECIKNGGCVFAAFYENHVIAFASLPYDFFGSSNQYVD
                     LAELYTSFEFRGLGTGKQLFALCAEKARQWGAKKLYISAHSAEETQAFYRSVGCVDAVE
                     INQQLSDKEPFDIQMEYIL"
     gene            complement(2782..3090)
                     /locus_tag="B7C51_RS26350"
     CDS             complement(2782..3090)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS26350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_158530476.1"
                     /transl_table=11
                     /translation="MGYQMIVKKQVGRQVHKPVHSNRHDVYKELTLLGIGFYAVRTKPT
                     SRVMRLFCLLNLIMAMYILAASTSQIKLSNFINSFCSIWLPNLLLSFYLLFVFPYHP"
     gene            complement(3075..3281)
                     /locus_tag="B7C51_RS22965"
                     /old_locus_tag="B7C51_22960"
     CDS             complement(3075..3281)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS22965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B7C51_22960"
                     /product="hypothetical protein"
                     /protein_id="WP_024094129.1"
                     /transl_table=11
                     /translation="MKDLYTAGPYTNRSIYFAILCFIGIAVYIHIASFLESFIGIAVKQ
                     DQRSGWIVTQVIPDKKGDLWGIK"
     gene            complement(3419..3745)
                     /locus_tag="B7C51_RS22970"
                     /old_locus_tag="B7C51_22965"
     CDS             complement(3419..3745)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021858.4"
                     /locus_tag="B7C51_RS22970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22965"
                     /product="diadenylate cyclase domain-containing protein"
                     /protein_id="WP_083041346.1"
                     /transl_table=11
                     /translation="MTKPNSDCDVSPMLINLKEDIKLIDVRIQKVLENFDDENHCLLGE
                     FQSIFIDSERLEKYTEDPGGHRELMVQLWYPAKTGSDEPTAPYTANPKELASGLEHAFS
                     LPAR"
     misc_feature    3725..3740
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.23"
                     /tool="antismash"
     gene            4109..4672
                     /locus_tag="B7C51_RS22975"
                     /old_locus_tag="B7C51_22970"
     CDS             4109..4672
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025563.4"
                     /locus_tag="B7C51_RS22975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22970"
                     /product="RICIN domain-containing protein"
                     /protein_id="WP_083041347.1"
                     /transl_table=11
                     /translation="MAISDTHFSIKERGNLFNAEFGHMINDGAVVINEGLIFKVYKDRV
                     EIKGRDFATHTDIAYWEIPYNTGDLNEGQIGTALDETKVLDKNGDNEVTLYGSHDGTNQ
                     RWEFVYDKDKAAYQIKSVRDKDLVLAWNVVPNSRQVFATPNQYKEEQYWILEKLGDYYI
                     IKSKKDLNLVLDVEGSKTDNLTKL"
     gene            5057..5827
                     /locus_tag="B7C51_RS22980"
                     /old_locus_tag="B7C51_22975"
     CDS             5057..5827
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000855643.1"
                     /locus_tag="B7C51_RS22980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22975"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_042118476.1"
                     /transl_table=11
                     /translation="MAKPVLITKGVTKTYGTKNNLYTALDRIDLEVNEGEFVGIMGPSG
                     AGKTTLMNMISTIDTPTSGDIIIDGQSIVKMKEEQLALFRRNKLGFVFQDYNLLDSLTV
                     RENIALPLALSHVKAAGIDERVVRIAKKFGIDPILDKYPYQISGGQKQRCAASRALVSN
                     PSLILGDEPTGALDSKSATDLLESMKEMNEKDRVTILMVTHDAFAASYCQRVLFIKDGR
                     LFTELHREDLTRKQFFNAILNMLSSIGGGVSDVI"
     gene            5814..7766
                     /locus_tag="B7C51_RS22985"
                     /old_locus_tag="B7C51_22980"
     CDS             5814..7766
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1243: ABC
                     transporter, permease component"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017763700.1"
                     /locus_tag="B7C51_RS22985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22980"
                     /product="ABC transporter permease"
                     /protein_id="WP_083041348.1"
                     /transl_table=11
                     /translation="MTLFNLALRNMKRNFKNYSIYFFSMIFSIVIYYAFVAIKFNSQIQ
                     QAADGSKKISGALTFAGILLILFSALFIIYSNGFFTRKRKKEVGLYSLLGVRKRQIAKM
                     LAYENLFMGLIALVVGIGIGALLSSGFTKLLLVLMDSEMGVHFEIPAAAVLNTALVFFV
                     IILYTSFQGYRLIYRFKLIDLFKADSQGEKVPKGSLVIALLSVIMIGSGYYLAYDFAQA
                     AKKLNVRLDSLALIILFLTVAGTWLLFHFFTVILLRIRRKNKNSFYNGMNLVSTSQLLY
                     RIKGNATTLATIAILSAVTLVAIGTSVSLYFNVGKQTEMMYPYSYTYEVTSPEVNKKVD
                     QALNEFKGDHPVEKDLTIKTLQVKGGLHDEDKKFDVSKKLDDKNKPTIIAFSEFKKWAD
                     TFGKSVESKLGIGEAIKYDPNASLSKKWGFEEKQKTFSLVAGKETVNLKIIKSEEYSLK
                     NNLTIDAVVVPDQIYQKALQANPAQKETKTRLINVKDQNSSKELTAAIDKATNGEDENY
                     YKPYRSGMEDMGIMIFVGTFVGLVFLIATGSIIYFKQLSEANADKAKYDILRKVGVTPK
                     EMKKGIGKQIAFIFVAPLIVGILHSIVALNTATLIFNVSDKLPLVMSMVAYVLIYVGYY
                     FLTVRSYCDIVRKSV"
     gene            complement(8122..8898)
                     /locus_tag="B7C51_RS22990"
                     /old_locus_tag="B7C51_22985"
     CDS             complement(8122..8898)
                     /NRPS_PKS="Domain: Abhydrolase_1 (20-234). E-value:
                     3.5e-25. Score: 81.0. Matches aSDomain:
                     nrpspksdomains_B7C51_RS22990_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007432275.1"
                     /locus_tag="B7C51_RS22990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22985"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_083041349.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.5e-10, bitscore:
                     39.6, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 5.8e-17, bitscore: 60.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIVNLNGHSMNYIDRGEGTAVLFIHPPVLTSLNFIYQIQELSPS
                     FRTIAFDIRGHGKSQPSAQPITYPLIAEDIVQLMDLLGLNKCFLCGYSTGGTIVLEFLL
                     NYPDRAWGGVVIGGMSEVNDWRLKNLISVGAGLAKIGAVNTLAFSTAWGQTNKLSLFRK
                     LYKDARKGNARNIEQYYRYSLTCNCTSRLQEIRLPVLLIYGEKDRHFHPYAKILYDRLP
                     NSELVFISKANHRIPTKVPVLLNELIEKFVNKLGQL"
     aSDomain        complement(8197..8838)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B7C51_RS22990_Abhydrolase_1.1"
                     /evalue="3.50E-25"
                     /label="B7C51_RS22990_Abhydrolase_1.1"
                     /locus_tag="B7C51_RS22990"
                     /protein_end="234"
                     /protein_start="20"
                     /score="81.0"
                     /tool="antismash"
                     /translation="AVLFIHPPVLTSLNFIYQIQELSPSFRTIAFDIRGHGKSQPSAQP
                     ITYPLIAEDIVQLMDLLGLNKCFLCGYSTGGTIVLEFLLNYPDRAWGGVVIGGMSEVND
                     WRLKNLISVGAGLAKIGAVNTLAFSTAWGQTNKLSLFRKLYKDARKGNARNIEQYYRYS
                     LTCNCTSRLQEIRLPVLLIYGEKDRHFHPYAKILYDRLPNSELVFISKANH"
     misc_feature    8868..8883
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.26"
                     /tool="antismash"
     gene            complement(9179..9280)
                     /locus_tag="B7C51_RS28100"
     CDS             complement(9179..9280)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016423559.1"
                     /locus_tag="B7C51_RS28100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dihydroorotate dehydrogenase"
                     /protein_id="WP_104932489.1"
                     /transl_table=11
                     /translation="MGYSCGGYGLFTSTGTILVLFILLVIISRSFLY"
     gene            9608..>9715
                     /locus_tag="B7C51_RS28105"
                     /pseudo=""
     CDS             9608..>9715
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03601.1"
                     /locus_tag="B7C51_RS28105"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLKVSDYNAGQVTPWGGQGEFASDPTRLCVGFCGGF"
     gene            9717..9932
                     /locus_tag="B7C51_RS28110"
     CDS             9717..9932
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS28110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_230460859.1"
                     /transl_table=11
                     /translation="MQDSVAVSAADFVVVFSDVSTGAFSDVFTIVSKIVFTAVPAASNF
                     LPKSRLLKVKDAGKPLMSSDSGAYQE"
     aSDomain        10001..10297
                     /aSDomain="Heterocycloanthracin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing C protein in a
                     heterocycloanthracin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_B7C51_RS23005_Heterocycloanthracin_C_
                     RRE.1"
                     /evalue="3.80E-50"
                     /identifier="RREFam011.1"
                     /label="B7C51_RS23005"
                     /locus_tag="B7C51_RS23005"
                     /protein_end="99"
                     /protein_start="0"
                     /score="158.8"
                     /tool="antismash"
                     /translation="MTTLNPSMRLKVKGDTSFLPDANGSVYFRNNLVSFQMEGEMIDKW
                     IEMLIPVFNGENTLEDLTDGLPEPHRDRLYEIAELLYQNGFIRDVSQDRPHQLK"
     gene            10001..11951
                     /locus_tag="B7C51_RS23005"
                     /old_locus_tag="B7C51_23000"
                     /pseudo=""
     CDS             10001..11951
                     /GO_component="GO:0005575 - cellular_component [Evidence
                     IEA]"
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030152 - bacteriocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Thiopeptide_F_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Heterocycloanthracin_C_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003340798.1"
                     /locus_tag="B7C51_RS23005"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_23000"
                     /product="putative thiazole-containing bacteriocin
                     maturation protein"
                     /pseudo=""
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     6.7e-48, bitscore: 158.8, seeds: 5, tool:
                     rule-based-clusters)"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 1.8e-10,
                     bitscore: 38.9, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTLNPSMRLKVKGDTSFLPDANGSVYFRNNLVSFQMEGEMIDKW
                     IEMLIPVFNGENTLEDLTDGLPEPHRDRLYEIAELLYQNGFIRDVSQDRPHQLKNQVLK
                     KYASQIEFLDNLCGSGAYRFQTYRQAKVLAVGSGPFFVSLVAALFESGLSKFHMLITDT
                     LPTNRQRLTELADHACISDPEVAVKEITLNRGDQHGKRLYFRMTRFYMFHRRVILRS"
     aSDomain        10022..10267
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_B7C51_RS23005_Thiopeptide_F_RRE.1"
                     /evalue="1.00E-12"
                     /identifier="RREFam004.1"
                     /label="B7C51_RS23005"
                     /locus_tag="B7C51_RS23005"
                     /protein_end="89"
                     /protein_start="7"
                     /score="38.9"
                     /tool="antismash"
                     /translation="MRLKVKGDTSFLPDANGSVYFRNNLVSFQMEGEMIDKWIEMLIPV
                     FNGENTLEDLTDGLPEPHRDRLYEIAELLYQNGFIRD"
     gene            11948..13887
                     /locus_tag="B7C51_RS23010"
                     /old_locus_tag="B7C51_23005"
                     /pseudo=""
     CDS             11948..13887
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03882"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019003927.1"
                     /locus_tag="B7C51_RS23010"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_23005"
                     /product="TOMM precursor leader peptide-binding protein"
                     /pseudo=""
                     /sec_met_domain="TIGR03882 (E-value: 7.6e-45, bitscore:
                     151.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAVVIIGEGLLADFVHSELSGSCQVIRQTNFMTEMPREAELVLL
                     LRDSWHPSAFHDAEKLLHNTGVSWIRGFISFGEGVIGPLVQPNKPGCSQCADMRRMLAG
                     SDRKEMSELQLKTLALGKVPRDVWASRTGLLHLSYLLTAEVQRVLQGSPACSEGRVYLI
                     NLKTLESSLHFFLPDPQCSFCGQLPDDSSESAQIALQPSPKASADSYRTRSMVELKDVL
                     ARDYLDTRTGLMNGKMVDLKSAFSEVSVNLPLFMGMK"
     gene            13912..15504
                     /locus_tag="B7C51_RS23015"
                     /old_locus_tag="B7C51_23010"
     CDS             13912..15504
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003252868.1"
                     /locus_tag="B7C51_RS23015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_23010"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_083041351.1"
                     /sec_met_domain="PF00881 (E-value: 5.9e-09, bitscore: 34.4,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLESFVHDLHFETDKARPPELEVDWEDAPLSYKLYRGLPVIPFS
                     PEIPLSVETRDISGQPDFHEIGHFLWYVYGLTQICQSVLPLDARNEGMNIFHSYRRFTP
                     SGGALYPNEIYVYLKLEDLPFGVYHYDVAHHRLILLREGDFDLYLRRALGNRCDVSACF
                     GTVFVSTFFWKNFYKYYNFSYRLQGLDAGVVIGQLLEASKRFGFASRVYVQFLDRAINH
                     LLGLSEQEESVYAIIPLSKKPVNIRRVYKKEEKEADVSATGLCRSLAAVRHNHYVRSRR
                     VKEYPDLIRMNEASMLESTLSFKRIESKKCINYGLKVAFLPRVKKLGYDFAAVCRKRFS
                     PEMDFVLSKVSNHELSALLQEAAASFLYQNDLDEIGGTDWLTGNRVELYVCLHGVEGIP
                     DGAYRYDGTFHALWEIEPGNQRFLLQRAMTFGNVNLFQVPFCFHVIGDKDHLKTVLGYR
                     GYRIQQMEAGMLVQHLLLAASALGMGGHPLLGFNVSMCDEIYRLTREEKTCLIQIPVGY
                     YRQRPRLEGSIHS"
     gene            15727..15999
                     /locus_tag="B7C51_RS23025"
                     /old_locus_tag="B7C51_23020"
     CDS             15727..15999
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000392443.1"
                     /locus_tag="B7C51_RS23025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_23020"
                     /product="BhlA/UviB family holin-like peptide"
                     /protein_id="WP_077995401.1"
                     /transl_table=11
                     /translation="MEEQIFNTALNIGIFGALFIWLLFTTMKKNEVREKEYQKTISENQ
                     EVIREQVKSFSLLSSDIAEIKGILKGKHEEEVLNDGNQKNVSRPK"
     gene            15965..>16381
                     /locus_tag="B7C51_RS23030"
                     /old_locus_tag="B7C51_23025"
                     /pseudo=""
     CDS             15965..>16381
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016097769.1"
                     /locus_tag="B7C51_RS23030"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_23025"
                     /product="N-acetylmuramoyl-L-alanine amidase family
                     protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEIRKMLVDPSKYGIKCPNKMAPKYITYHNTANDASAENEIRYMI
                     GNNNEVSFHFAVDDKEAVQGIPFDRNAWHCGDGNGTGNRQSIGVEICYSKSDGNRYYKA
                     EDNAAIVIAKLMTQFCIPIENVVPHQHWSGKYCPH"
     gene            complement(16425..17555)
                     /locus_tag="B7C51_RS23035"
                     /old_locus_tag="B7C51_23030"
                     /pseudo=""
     CDS             complement(16425..17555)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1164: transposase
                     IS3/IS911 family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611566.1"
                     /locus_tag="B7C51_RS23035"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_23030"
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTKKYDKEFKLQSVRLIQEDGKSVAQVAREMGLHENTLYRWIAEF
                     KNAGNQAFPGSGQLKPEDKALRDLQKRIRNLEEENDILKKAMHYFAKDRR"
     gene            17705..18331
                     /locus_tag="B7C51_RS23040"
                     /old_locus_tag="B7C51_23035"
     CDS             17705..18331
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS23040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B7C51_23035"
                     /product="hypothetical protein"
                     /protein_id="WP_077995399.1"
                     /transl_table=11
                     /translation="MEYEYIPKPNNILSKEEYLEKFQTFLEESSRNPDIIWEVVSDTMA
                     SLDKDFKPNATTLAIFKEILPAFLSKESIDFLRYILRNGLQNIDEMNKINTKLTTKLHL
                     LVLKNGINFRCAENYLANPMAYALLQTWFSSLDKEALYMQILRADKESLNLRLDVHSMY
                     AFTRHLIEKLIQLLETHDIPEESQLQLVDRMFSYLVKSGVITKHE"
     gene            18324..18953
                     /locus_tag="B7C51_RS23045"
                     /old_locus_tag="B7C51_23040"
     CDS             18324..18953
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS23045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B7C51_23040"
                     /product="hypothetical protein"
                     /protein_id="WP_077995398.1"
                     /transl_table=11
                     /translation="MNNEIKKEDVVVQIESYLKKKGKQELQCLPFENVDVISDYIDFTY
                     NTSRNTDVDKILEIFKSTRAQTSSTGEVGPMDELNKSLLERMERDIREHRQEVANRDSR
                     LQAEMQEREKRIREDNKEREERIFKVLDTISSEVKQIRKDLHGEMKEMKSELNNEVRHI
                     RNEISDNTKHVQSLVRQNQWGYITAVLAVLAICATISFTVWAALIK"
     gene            19595..21376
                     /locus_tag="B7C51_RS23050"
                     /old_locus_tag="B7C51_23045"
     CDS             19595..21376
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012376.4"
                     /locus_tag="B7C51_RS23050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_23045"
                     /product="RICIN domain-containing protein"
                     /protein_id="WP_083041353.1"
                     /transl_table=11
                     /translation="MQNQKSNRLLADGIYKIQVENSKVFQYEGGSVVISEWTGQDNQLW
                     EFYYVSNWQAVDGYCIRPVGTTKYLAWDRNKGNILTVREHDRDIEYTKYWKIYELNNRY
                     IIENHHYPFPYLNVNGDIVNVSQGQRYEFTLVKDPDIPNPNFNDISLVITSDPQYPWTP
                     KMDDGDNSESDSETRSVSERLIREQYQDINSYTNSVPNSSVLINGDITAFGHGWQRDKM
                     KNLLSTLNKKYYYGLGNHDIENNKNDCAMDECFRASMQDYQIHVDGHKLPKSQVDFEKK
                     EYMTVLWYEGSFYYTVDFGGIYSIQLNNFPTMTASCGMNGYGKPGYTMEPNLDWLEQKL
                     KFASQSGKIIIVNVHKPDDWKGGPNERFKKLLRDYNVTAVFCGHYHKQCGRGYYSSYFG
                     DVPVFLSGSASQRTYLILEQSIYRKEINIYSVRDNNWKNKKLEQRIEINSLINGKYQIA
                     TALNDKSVLDLNGPNHVTLWENNGGSHQRWNFVYDKKKEAYQIYSVSDKNLVLAWNAIP
                     NSRQVFATPNQYKEEHYWLLEATGDGYYIIKNKKEPTLVLDVTDSETANGTKIKVHPQH
                     PPTDAIWNINAQKFKLI"
     gene            21522..22745
                     /locus_tag="B7C51_RS23055"
                     /old_locus_tag="B7C51_23050"
     CDS             21522..22745
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1130: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019007377.1"
                     /locus_tag="B7C51_RS23055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_23050"
                     /product="IS256 family transposase"
                     /protein_id="WP_077995397.1"
                     /transl_table=11
                     /translation="MAQYQINVDSQLLHQLFLGNSQDAGVAKLLESVLNQVLQAQVSEQ
                     VEADRYERTENRKAYRNGSYPHGLHTRVGTITLSVPRIRGGKFTTELFSRYQRSEQALI
                     LAMMEMVVNGVSTRKVSQVTEELCGTEFSKSTVSDLCKRLDPIVTAWNNRSLADSLFPF
                     VLVDAMYLKVREDGRVRSRGIMIAIGVNTEGYREVLGLMLGDTESEASWSEFFSSLKGR
                     GLRGVDLITSDDHGGLVRAVRQQLQGVTWQRCQTHFTRNVLEASPKALKDEIHGRLRSI
                     LDAPDTGTARLLLKQTLAAYEDKAGKAMGVLESGFDDATAVLMLPERYRKRLRTTNSVE
                     RLNEEVRRRERVIRIFPNRESVIRLIGALLMEQDEKWAAGKKYLDMTEYMEWRKDRPKS
                     DAKVTRIM"
     gene            23190..25253
                     /locus_tag="B7C51_RS23060"
                     /old_locus_tag="B7C51_23055"
     CDS             23190..25253
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025805.4"
                     /locus_tag="B7C51_RS23060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_23055"
                     /product="pre-toxin TG domain-containing protein"
                     /protein_id="WP_083041354.1"
                     /transl_table=11
                     /translation="MRKITNVVVLFIFAVISFVTPYTQTVFAEETRLTLEKETAIYNAP
                     SFSTKTISTISPQKVKVLEKRPDGWFKVATWLGDKWIAPKGAVVKPRKTEVFLRLYEGP
                     DLDKTTKYSLSYVNYVLGLDGTADGFVKIKTEKGDMWIIEDTVPLQLTKSTPLYDYSWI
                     GGQSIGVVSPQKVKVLEKDPYGLYRIVSWLGEKWIAPHGEKYKLTKPTVLYDHPADNTK
                     SGFTLSPQTVTLLEFRSPWFYKINTWVGEKWISTIGTALSRDNDEYIKYDNFQTDSILE
                     SDMFVNLQSSKEVLQKYYDDLAQFQEKLNFIDWNEFRKHFENLPDFNFDFSEFDKSLEE
                     LAKWSASMDGYWEDFNASIQHMSSSVGEILSNIHIDTSKIEEAGDMIKRACDEINEGLK
                     KMKSGLDVINGAVSNIHQNLTDMNTGMKQAQAGLNKANNGMSVANSAIDQAKKAHDTLQ
                     KYLKDPIKIKKETRGSDLPKLKSLGFDFDFSSYLTLENVSVAIDLIPIVGNIKAGGEVI
                     SGYDPITGVPLEGPDYVLGIIGIIVGGEFKQVGKIAGKATELEAKANKITKSMVTKVPS
                     EIKLSTGNIKHLWNGHSFESFANQIPYLMKTKSRDAVEKQLSNISFFNKNLSKEEIVSS
                     VGKAANEALSNGVTHGQYKTKINGEIITVAFDNGTFQTAWGTHNYTLSDFGY"
     misc_feature    25351..25365
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: weak, score: 17.19"
                     /tool="antismash"
ORIGIN
        1 gatttgagtt atttggccat tgctatctat ctggctattg ccggaagttc attatatgct
       61 ttggacagta ttttgttccg tacaaagaaa taatctgatc cgcaaatcat tcgaagataa
      121 aaaaacgaac agccgcttac ttaacgtggt atttggccga gaagctcaag gtgaggccta
      181 atattagtga acattgtata ggcatccaaa ccgatacgcc gcaatatgat agagtatccc
      241 atatgtgagg tgagaggtta tggctgttgt taaagcaagt agttcggata tcgacctcct
      301 ggcaaggctg ctccgtgctg aagctgaagg ggaaggtgaa caaggcatgc tgctcgtcgg
      361 taatgtcgct ataaaccggg taagagccga ttgttccgat tttaaagata tccggacgat
      421 tccccaaatg gtttttcagc cgcatgcatt tgaagcgacg ctgtatggtt atttttatca
      481 gaaagcgagg gacagagaaa gacggttagc ccgcagaagc attaacggtg aaagacactg
      541 gcctgctaaa tttagcttat ggtattttag accgccgggg gagtgccctc ctacatggta
      601 taatcagcct ttagtcggaa gatacaaaaa gcactgtttc tttgaaccga cagccgaaac
      661 gtgcgaggac gtgtatagta cgttctgaaa ttttgttagt gagtaaagat tataatagcc
      721 ggattcctga ccgaaggaag tccggctatt ttcaatgctg atcatgggag tctatggttt
      781 cggatatttg aacaaccggc cacttctctt ttcgcaaagc attcatcagt tcccggcttg
      841 catgcaaatt atcctgaacc agctggtgcg gggtcaaggc catccattgg tttagggata
      901 tatcggcaaa ccggttgctt ttgaacattt ccagaaacca taaactttcg tccccaatat
      961 tctgaatgta atgtccgaag gcaaacggta cataccccac atcacctgaa cggcaattga
     1021 acgtacgggc tttgccgcct gcggcaaaaa ctgtcatgcg ccctgttccc gaaatataat
     1081 actgccactc gtcgttattt gggtgccagt gcagctctct cattcctccc ggcttgacct
     1141 caactaaagc ggccgcgata gttgttgaag cggggaaatt aatagaatcg acaatgcgaa
     1201 ccgatccccc ggagtacgga ttggattttg tgcgaacaga cgatgggtaa agcttttcgg
     1261 aaccgtaccg ttcgaatcag gtactttttg agtttcaaga ggtccgggca cttgcccttg
     1321 gtacatgtat atttgcttgt ctggaatttg agcaagagca ctttcgggga tgccgaaatt
     1381 tgcggcaagc acatcttttg gcgtatgtgc gaaccaatcg gagatgctga aagtatcaaa
     1441 ttctgaaaag ttgccgtcat cgaagacaag aaggaactcg catccttcct tcagcccttg
     1501 aatggagtgg ggaatgccgg gagggaaata ccagaggtca cccatttcga catcggcaat
     1561 aaagttgcgc ccgttctggt ctaccgcagt cacgcgggca catcctgaaa tcataaaggc
     1621 ccattccgcc tgtttatgcc agtgtaattc gcgaacacca cccggtgtca atcgcatatt
     1681 taccccggca agggtagtcg cgataggcag ttctcttact gtcacttccc gtgaccaacc
     1741 gccatgactt aattgcatgt gggtatcgga gaaagaaaat ttcatattgg gaatagtacc
     1801 agcatctgta tatggcggaa ccagcatatc aggattttcc agatcacgca ttacatcccg
     1861 gggaccggta tctgttgcac ccgcaccgtc atcccttatc ggttgtggaa tgtttacatc
     1921 atgagggtaa gacggatttt tcataacttt tcctccaaga ttcagatttt ttgtcaaaag
     1981 cgactcagga ttgttttact aatttatgag gataatgatt tggatatgtt tttagcgggc
     2041 atcctgacca gaatcataag acttcccaaa agagtacacg ataaaagagc cgaaatttcc
     2101 ggggtataac aaacgggagg gctgttgtgc tcaacagctc tcccaatgcg cacgatatac
     2161 taaaggatgt attccatctg aatatcaaaa ggttctttat cagataactg ctgattgatt
     2221 tctactgcat ccacacaccc gacggaccga taaaatgctt gcgtttcttc agcagaatga
     2281 gctgaaatgt ataatttctt agcaccccat tgccttgctt tttctgcgca tagggcaaat
     2341 aattgttttc ctgttcccag acccctaaat tcaaaggaag tgtacagttc cgccaaatcc
     2401 acatattgat tggaacttcc aaaaaaatca tacggcagtg aggcaaatgc aataacatga
     2461 ttttcataaa atgccgcaaa tacacagccg ccatttttaa tacattcggt gaaatgtccg
     2521 gttatcaaat tacttttttc ttcgctgctc cactgttcca caaaaggatg ttctattaaa
     2581 gcctttttat tgtctattat tctccaaaca tttttcactt cctgaaaacg attaaaatga
     2641 tccaatagtt cttttgtcaa atctttttct gaaagtaatt tatacttaat attataattt
     2701 gaattcatat tatccccacc ttaagtcatt ttttcctaaa aaaatgcccc ccgataatat
     2761 gagaagatga tttttctcct gttatggatg gtatggaaat acaaatagta aataaaagga
     2821 gagcagtaag ttaggcagcc agatggaaca aaaggaattt ataaagttgg ataacttgat
     2881 ttgtgaagtg gatgctgcca atatgtacat ggccataatg agattcaaca ggcagaacag
     2941 tcgcattacc cgggatgttg gctttgttcg aacggcataa aagcctatgc caaggagtgt
     3001 tagctctttg tacacatcat gccggtttga atggacaggt ttatgtactt gccggccaac
     3061 ctgtttctta acgatcattt gataccccac aagtccccct ttttatcggg aataacctga
     3121 gtcacgatcc agccgctacg ttggtcttgc tttaccgcaa tcccgatgaa ggattccaga
     3181 aaggaagcaa tatgaatata tacggcgatc ccgataaaac aaagtatagc gaaataaata
     3241 gaacggttcg tgtatggtcc ggcagtgtat aaatccttca tgattatgaa tcgcctgacc
     3301 tgattataac atcattgttc catgcaaagg caagctttac gggttcaggc gtgcctagtg
     3361 cttttcaaat cttatttcgg gatagcgttc cacgatcttg tccaaggcat cggaattatc
     3421 accttgccgg gagcgagaat gcatgctcca aacccgaagc taattctttg ggatttgcgg
     3481 tgtatggagc tgtcggctca tcacttccgg tcttagcagg gtaccaaagc tgaaccatca
     3541 gttctcggtg acctccgggg tcttcggtat atttctccag tcgctcagaa tcaatgaaaa
     3601 tactctgaaa ttcaccgagc agacaatgat tttcgtcatc aaaattttcc aatacttttt
     3661 gaatgcgaac gtctataagc ttaatgtcct ctttcaaatt tatcagcata ggtgaaacat
     3721 cacagtcact gtttggtttc gtcattctct ggattacacc ccatttttgt aaggaatcgt
     3781 gcttattatt cccaaaatca ggtattcaaa ctccattcat acgaaccagt catttggctt
     3841 gttttatatg tttttcttga taaactgatt ggcacacttt agggatcatt ctttcatctg
     3901 agtgaaaagt ataagctttt ttagacattt ttaaagttat atttaaagtg taatcgaaag
     3961 gaggattgat tttcgtgtag cactaaaatg gttagtcatg catagctaac ggaatttttg
     4021 aaagcattta catgtaatta tctcaaacga aaacgaagga gaagaaaaca tgaataaaac
     4081 aacatgaaca aaaccagaga tcagttttat ggccatttcc gatacgcatt tctccatcaa
     4141 agagagaggt aatttgttta atgcagagtt tggtcatatg attaatgacg gcgcggtcgt
     4201 gattaatgag gggcttattt tcaaagtgta taaagacaga gttgaaatta aaggaagaga
     4261 ttttgctact cacactgaca ttgcttactg ggagattccc tataatacag gcgatcttaa
     4321 tgaaggtcaa attggtactg ctttagatga aacaaaagtt ttggataaaa atggggataa
     4381 tgaggttaca ctgtatggta gccatgatgg gactaatcaa agatgggaat ttgtatatga
     4441 taaagataag gctgcctatc agataaaaag tgtacgtgac aaagatttag tactggcttg
     4501 gaatgttgtc ccaaattcca gacaggtttt tgctacacct aatcaatata aagaagagca
     4561 gtattggatt ctggagaagt taggtgatta ttatattata aaaagtaaaa aggatctgaa
     4621 tttagtacta gatgtagagg gttctaaaac tgacaatttg acaaaattat agtatacgaa
     4681 caacataatg gtgaaaatca aaaatttaaa ttgggaaaag tataaccgac tctggcagtc
     4741 ctttttgata atcactcaaa tggcaccaat atttattgct ttaatcaata gaacttattt
     4801 cggccgcccg gcaaatgctg tggcggtttt tttattcgag aaaacgttca agtaaaatat
     4861 agcacgcccc acgacttctt gtaaaaaata aaatgtgaaa gcttaatgat ttatatgaaa
     4921 tttcttttga tgacatggct gttttctacg tgaccacaat gtaagattgg gtcactttaa
     4981 tcaatggttg cttattcaga tttcatagat aattggattt gattgagaaa ccgtataaaa
     5041 agaagggaga aaaacaatgg caaaacctgt actgattaca aaaggtgtta cgaaaactta
     5101 cggtactaaa aacaatttgt atacggcttt ggaccgtatc gatttggaag tgaatgaagg
     5161 ggaattcgtt ggaattatgg gaccatccgg tgccgggaaa acaactctta tgaacatgat
     5221 ttccactatc gacacaccta cttccgggga tattatcatt gacggacaaa gtatcgtgaa
     5281 aatgaaagag gaacagttag ctctgttccg ccgaaacaag ctgggttttg ttttccagga
     5341 ttacaacctg cttgactcgc tgacagtcag ggaaaacata gccctgccac ttgctctttc
     5401 ccatgtgaaa gctgctggaa ttgatgagcg ggtagtccgc attgccaaaa aattcggcat
     5461 tgatccgatt ttggataaat acccttacca aatttccggg ggtcagaaac agcgctgtgc
     5521 ggcttcccgt gcgttggtat ccaatccgag cctgatcctg ggggacgagc cgacaggcgc
     5581 tttggattca aaatcggcaa ccgacctgct ggaaagtatg aaagagatga acgaaaaaga
     5641 tcgggtgacc attcttatgg tgactcatga tgcttttgct gccagctact gccaacgagt
     5701 cctgttcatt aaggatggcc ggctgtttac ggaactgcac agggaagacc tgacccgtaa
     5761 acaatttttt aacgccattc tgaacatgct ttcatctatc gggggtggag taagtgacgt
     5821 tatttaatct tgctttacgt aacatgaaga gaaattttaa aaactattcc atctatttct
     5881 tttccatgat ctttagtatt gtgatctact atgcctttgt agcgattaaa tttaattctc
     5941 aaattcagca agcagctgat ggttccaaga aaatatcggg agctcttact tttgctggta
     6001 tattgttaat cctgttctcc gctttgttta ttatttattc caatggtttt ttcactcgaa
     6061 aacgcaaaaa agaagtaggg ttatactcgc ttctgggtgt gagaaaaaga caaatcgcca
     6121 aaatgctggc ttatgagaat ctgtttatgg gcctcatagc cttggtggtt ggtattggca
     6181 ttggcgcttt gctatccagt ggttttacta agctattgct ggtgcttatg gattcagaaa
     6241 tgggtgtcca tttcgagatt ccagcggcag ccgttctcaa cacggccctt gttttctttg
     6301 tcatcatctt atatacatct tttcaaggat acaggctgat ttaccgtttc aaactgattg
     6361 atctctttaa ggcggacagt cagggagaga aggttcccaa aggctctttg gtgattgccc
     6421 tattatccgt tataatgatt ggttccgggt attatctggc ttatgatttt gctcaagctg
     6481 ctaagaaatt aaatgtgcgg ttggattctc ttgctttgat tattttgttt cttaccgttg
     6541 ccggaacttg gctgctgttc catttcttta ccgttatttt gctcaggatc agacgcaaaa
     6601 ataaaaacag tttttacaac ggaatgaatt tggtgagtac atcccaactc ctctaccgga
     6661 ttaaaggaaa tgctaccaca ctggccacca tcgctattct cagcgcagtt acgcttgtag
     6721 ctattgggac atcggtctct ctttacttta atgttgggaa gcagacggaa atgatgtatc
     6781 catacagtta tacttacgaa gtgacctccc ctgaagtgaa caagaaagtg gatcaggctc
     6841 tgaacgaatt caaaggagat catcctgttg aaaaggatct tacgataaaa actcttcagg
     6901 tgaaaggggg attgcatgac gaggacaaaa agtttgatgt gtcaaaaaaa ctggatgaca
     6961 aaaataagcc aacgattata gcgtttagtg aatttaagaa atgggcggat acttttggaa
     7021 agagtgtaga atcaaaactg gggatcggag aagctattaa gtatgatcca aatgcttctt
     7081 taagtaagaa atggggcttc gaagagaagc aaaaaacatt ttccttagtt gcgggaaaag
     7141 aaaccgttaa tttgaagatt attaaaagtg aagaatactc attaaaaaat aatttaacta
     7201 tcgacgcggt tgttgtacct gatcaaattt atcaaaaagc tttacaggca aatcctgccc
     7261 aaaaggagac aaaaacccgt ttaatcaatg taaaggatca gaatagcagt aaggaattaa
     7321 ccgcagctat tgataaagct acgaacgggg aggacgaaaa ttattataaa ccataccggt
     7381 ccggtatgga agacatgggg attatgatct tcgtggggac gtttgtcgga cttgttttct
     7441 tgattgctac aggatctatt atctacttca aacaattgtc cgaagccaat gcggataaag
     7501 ccaagtacga catattacgc aaagtaggag taaccccgaa ggaaatgaag aaggggattg
     7561 gcaagcaaat tgcctttatc ttcgtggcac ctctgattgt aggaatctta cacagtatcg
     7621 ttgccctcaa cacggcgact cttattttta atgtttctga caagcttccg cttgtaatga
     7681 gcatggtggc ttatgtgctt atctatgttg gttactactt cctaacagtc cgttcttact
     7741 gcgatattgt aagaaaaagt gtatagatga aggataaggg acctattcaa aagtcatcaa
     7801 ggatgataat tggatagtcc cttattttta aaacatcgca aaatgacaaa ataagcttaa
     7861 ataaaaaaag cagatatgat aaaaatgtaa tgtttagcgg cgtgggcggt tggctctgac
     7921 ttaagtgaaa accaaatatt aaacagaacc tattgaacct atgctattat caaataaacg
     7981 aagagaatgt cattttatga tgatgaatgg aaggatagtt taaaaaaagg gcctatttat
     8041 ggttctgctc actggtattt ctgctgtcga tttcagaagg tttatttgat aaaaagtatc
     8101 attttggata caatcccttt ttcataattg accaagcttg tttacgaatt tctcaatcaa
     8161 ttcatttaat agaacaggta ctttcgttgg aattctatgg ttagcttttg aaatgaaaac
     8221 cagttcacta tttggcaacc ggtcatataa aattttcgca taggggtgga aatgcctgtc
     8281 tttctcaccg taaatcagca gaacaggaag gcggatttcc tgaagccgtg aggtacaatt
     8341 acaggttaag ctgtaccggt aatactgttc tatgtttcgg gcatttcctt ttcttgcatc
     8401 cttgtataat ttgcggaaca aagagagctt gttagtttgt ccccaggctg tagaaaatgc
     8461 gagtgtgttt acggctccga ttttggcgag gccggcacct acggatatca agttttttaa
     8521 cctccaatca ttcacttccg acattcctcc gataaccaca cctccccaag cccgatcagg
     8581 atagttcaga agaaattcaa gtacaatggt acccccggta gaataaccgc ataagaaaca
     8641 tttattgaga ccaagaaggt ccatcagttg cacgatatct tccgctatta gcgggtaagt
     8701 aatcggctgt gcggaaggct ggcttttccc gtgtcccctt atgtcaaaag caatagttcg
     8761 aaaagatggg gaaagttcct ggatttgata aatgaaattc aagcttgtaa gtactggagg
     8821 atgaatgaag agaacggcag tcccttctcc acgatctata taattcatcg aatgtccgtt
     8881 taaatttacg atagtcattt tgttgtaaac tccatgtttt attatctgta ggttgttttt
     8941 taaattacga tttagaatat ccaaataaaa aaaataaatt caataaatgg atatcaccgt
     9001 cttttgaaaa gaaaaatcgg gcaaaacaga agtggacata tcgggcagtt tctcgggatg
     9061 cgctgggttt attgggaagg cagggatgta ccggaagata gcgggctttc aaattccgtt
     9121 tttgagtttt ctaataaaaa aacgagcgcc ttgagccaag gcgctcctgc gaattcaatt
     9181 aataaagaaa agaacgggag ataataacca gcagaatgaa gagaaccaga atagtacccg
     9241 tgctagtaaa caagccgtaa cctccacagc tgtaacccat ttttatccaa ctccttttca
     9301 ttaagaataa gctttacact atatagtatg agggaatatc aaattgagat tgtgcagatg
     9361 ttcctgttat agttgcatca ttttgaggtg tataaattag gtattcaatt cagtaacaag
     9421 agcggactgt atttcataaa gtgaattatc ttttactgag gaggattgtc gaagagttga
     9481 ccgatttaac tggcatgact taaatgatct tcttaagttc ctagtgaact gcaaactgca
     9541 aggtgatgtt ttatgaatta aattcggagg gtgtttaaga atggataatt tcaaacaaga
     9601 cttacaaatg ctgaaagttt ctgactacaa tgcgggacag gtaacgcctt ggggcggcca
     9661 aggcgagttc gcttctgatc cgacccggct gtgtgttggt ttttgtggag ggttttgtgc
     9721 aggattctgt ggcggtttct gcagcggatt ttgtggtggt tttcagcgat gtttccacag
     9781 gtgctttcag cgatgttttc acaattgttt ccaaaattgt tttcaccgct gtgcccgctg
     9841 cttctaattt tctgccgaaa tcaaggctgc ttaaagtgaa agacgccggt aagcccctga
     9901 tgtcatcaga ctcaggggct tatcaggaat gaaggacaaa tagccataca tagtcttaag
     9961 gagatagatg gaattaaagg ttcaggtaag gaggaatgaa atgacaactt tgaacccttc
    10021 tatgcgcctt aaagtgaaag gggatacgag ctttctcccc gatgcgaacg gaagtgttta
    10081 ttttcggaat aacctggttt cgttccaaat ggaaggcgag atgattgata agtggattga
    10141 aatgctgatt ccggtcttta atggagaaaa tacactggaa gatttgacag acggattgcc
    10201 tgaaccacac cgggaccgtt tgtatgaaat tgccgagttg ttgtaccaaa acggttttat
    10261 ccgggatgta agccaagacc gtcctcatca attgaaaaat caggtgctca agaagtacgc
    10321 ttctcaaatt gagtttttgg ataatttgtg cggttcaggt gcataccggt tccaaactta
    10381 tcgccaagcg aaagtattag cggtcggttc tggccccttt tttgtttctt tggttgctgc
    10441 tttattcgaa tcgggattgt caaagttcca tatgctgatc acggacacgc tcccgaccaa
    10501 tcggcaaagg ctgaccgaat tagcggatca tgcctgcata tcggatcctg aggtagcggt
    10561 aaaggaaatc accctgaata ggggggatca gcatggcaag aggctgtact tccgtatgac
    10621 tcgattttat atgtttcaca gacgggtgat tttgaggagc taaagcttct tcattcagtt
    10681 tgcagagtgg aaaagaaaat gtttcttcct gccatatgca ttgaacaggt gggaatggcg
    10741 ggtccgatag ttcacccgga ttctcaggga tgttgggagt cagctttccg ccgcttacac
    10801 aaatcagtac tatgcaaaga ttcacagaac catatatatt cttctcccgc gggggcgatg
    10861 ttggcgaata taaccgcatt tgaattgtta aaggcggtta ctggagtaac tccatcggag
    10921 ctcgataata aagttttctt gcttgatctg gaaacgatgg aaggagattg gcatacattc
    10981 ttgccgcatc cggcagtatc cggacatacg tcaactgaaa tgattcaaga tatcgagaag
    11041 cagcttgggc aaaactccac aagaaatgaa ccgaaccgat tgttccaagt tttcacccgg
    11101 ttgacatcac caaagacagg gatttttcac atttgggacg agggggatct gcggcagctt
    11161 ccactggctc aatgccgggt tcaggcagct gatccgttgt ccgcagggcc tgccgggctt
    11221 ttaccggaga ttataagccc tggtctaacc cacggggagg caaggcgtga agcaggcctt
    11281 tcgggaattg aagcgtatat ttcacgaatg acgcatttgc tttttaaggc cccctgctct
    11341 tatgcggaag aagtttgctt ggagaaagaa tttgtcggca ttggagccgg agagactcta
    11401 gcagaaagta tttgtcgggg ttgcaaaagt gtttgtccca ggagatgtac aaacagcaga
    11461 caagtcggaa ctttcttgtc aaacgtgttc ggttaagtga gatcgaggat gaacactgcc
    11521 ggttctattt gcgggtgttg actgctatgc agggagaacc ggtaatcggt tatggggacg
    11581 gacttttcgg tttccctgcc gcatgggtca gaacgggcgg cagatggtac ggcagtgtat
    11641 ccttaagtcc gacaatggca ttgcgaaatg tgctggagta ctcgctgctc aaggtacaaa
    11701 ataacggggc cggtcccagg gcgcagggtt gggaggattc tagcgtgttt ctagaggata
    11761 agacatcact aagccttaag atccctcatt ctaaagaaac ggcatattcg gagattctta
    11821 agtcggctct ccaggtactt aaacgaagcg gcaagcggat tttgatcttt gatgtagccg
    11881 tggagccgtt tttaaaagaa gcgcggataa gcgtagttgg tatactgatg cgagaggagg
    11941 aatcccggtg aaagcagtgg tgattatcgg agaaggtttg ctggcagatt ttgtacattc
    12001 ggaactttcc ggttcatgtc aggttattag gcagacaaac tttatgacag agatgccgag
    12061 agaggcagaa ttggttttgt tacttcggga tagttggcat ccatcggctt ttcatgatgc
    12121 tgaaaagttg ttgcataata ccggggtttc ttggataaga ggtttcattt catttggtga
    12181 gggagtgatc ggaccgcttg ttcagccaaa taagccgggg tgctctcaat gtgcggatat
    12241 gcggcgcatg ctggcgggaa gcgaccgcaa ggaaatgtcg gagctgcaat tgaaaacgtt
    12301 ggcgttaggg aaagtccccc gtgatgtatg ggcttcacgc acgggacttt tgcatttatc
    12361 ttatctgctc acggcagaag tacagagagt gctgcagggc agcccggctt gttcggaagg
    12421 ccgggtatat ttgatcaatt taaaaacgct ggagagctct cttcactttt ttcttcctga
    12481 cccgcagtgt tcgttttgcg gccagttgcc ggatgattca tcagaaagcg cccaaattgc
    12541 cctgcaacca agtccaaagg caagcgccga tagttatcgt acccgatcga tggttgagct
    12601 aaaagatgtt ctggccagag attatctgga tacccgaaca ggtcttatga atggaaaaat
    12661 ggttgacctc aagtcggctt tttccgaggt gagtgtgaat ttgcctctgt tcatggggat
    12721 gaagtgacgg ccggccggac tcattcttat tcagatagtg aaatgactgc cattatggag
    12781 gggctggaac gatattgcgg tttgacgccc cgcggtaaaa gaacctcggt tcatgacagc
    12841 ttccgcaatt tgtcggatca agccctcaat cctgtacaag tgggtgttta tacaaaagaa
    12901 cagtacgcac aacctgattt cccgttcgaa ccgtttgacc cggaccgctc tatagattgg
    12961 gtatggggct attcgttttt acgggaacag ccgattcttg tacctgaact gctcgcttat
    13021 tacagcatgg gttgcggaaa tggcctcgtc tatgaaacct ccaatggatg cgcattaggc
    13081 gggagcctgg aagaagccat cttttatggg attttggaag tggtggaacg ggatgcgttt
    13141 ttgatgacct ggtatgcgca actgcccctc ccgcgccttg accctatttc ctcaggtgat
    13201 ccggaattgc agatgatggt cgaacgattg ctagtggtag cagggtatga tgttctgttc
    13261 tttaatgcca cgatggagaa cagaattccg agtatttggg ctctggcaaa aaacaggaaa
    13321 cagaagggaa tgaatcttat ttgtgcggcc ggatctcatc cggatccggt tcgggcagcg
    13381 aaaagctcag ttcatgaatt ggcagccctg atgctggcgc ttgatgataa attggaagca
    13441 aacaaagacg aatatgtacg aatgttatac gattcttctc tggtgcgtca gatggaggac
    13501 cattccatgt tatatggttt acgggaatca gaggaacgac tcaatttttt attggatgat
    13561 aactgtccta tgtacacctt tgccgaagct ttcggacaga agaaacagca tgcggatctg
    13621 actgacgacc tgaaggatat tatagaggca ttcagagggt tgaacctaga cgtgattgta
    13681 gtcgaccagt caacacctga aatcgtacgc aacggattac actgtgtaaa agtgctgatc
    13741 ccgggaatgc tgccaatgac gtttggccat cacctgatac gattggcagg tttggatagg
    13801 gtacttaggg tgccgatgga actcggttat gtgaaagagc cattgagtta cggacagctc
    13861 aatccgtatc ctcacccgtt cccataagcc gatatatgga ggaagagaaa gatgagcctg
    13921 gaatcatttg tacacgatct tcattttgag accgacaaag caagaccccc ggaattagag
    13981 gtagactggg aagacgctcc gcttagttat aaactatacc gcggtttgcc cgtaattccg
    14041 ttttctccgg aaataccgct ttcggtagaa acccgggaca tctctgggca gcctgacttt
    14101 cacgaaatag gtcattttct ctggtacgta tatggtctta ctcaaatttg ccagtctgtc
    14161 ttacctttgg atgcaagaaa cgaaggcatg aacatatttc attcgtatag gcggtttact
    14221 ccttccggag gggcattgta tcctaatgaa atatacgtgt atctgaaact ggaggatctg
    14281 ccttttgggg tgtaccatta tgatgtggcg catcaccgtc tgatcttgct gcgcgaaggt
    14341 gattttgatc tctatttgag acgggcactc ggaaaccggt gtgatgtatc ggcctgcttt
    14401 ggtactgttt ttgtttcgac ttttttttgg aaaaattttt ataagtatta taacttttct
    14461 taccgtcttc agggtctgga tgcgggggtg gtgatcgggc aactgctgga agcgtcaaaa
    14521 cggtttggtt ttgcatcaag ggtctatgtt cagtttcttg atcgcgctat caaccatctg
    14581 ctcggtctgt ccgaacaaga agaaagtgtt tatgctataa ttccattatc caagaagccg
    14641 gttaatatcc ggcgtgtcta taagaaagaa gagaaagaag cggatgtttc tgcaaccgga
    14701 ttgtgccgga gtctggcagc tgttaggcat aatcattacg tccggtcacg aagggtgaaa
    14761 gagtatccgg atctgatcag aatgaacgaa gcatccatgc tggaatcaac gttgtcattt
    14821 aaacggattg aaagtaagaa atgtattaac tatggcctga aggtggcatt tctgcctcgt
    14881 gtaaaaaaac tggggtatga ttttgctgca gtatgccgaa agagattttc tccggaaatg
    14941 gacttcgttt taagcaaggt tagcaatcat gagctctcgg cactactgca agaagcagcg
    15001 gcctccttcc tttaccaaaa cgatttggat gagatcgggg ggactgactg gctgacgggg
    15061 aaccgggttg aattgtatgt ctgtttgcat ggcgtagaag gcattcccga tggggcatac
    15121 cgttatgatg gtacttttca tgctttatgg gaaatagagc cgggaaatca gcgattcctt
    15181 ttacagcggg ccatgacttt tggaaacgtt aatttatttc aggtcccttt ttgttttcat
    15241 gtaataggag ataaggatca ccttaaaacc gtcttgggat acagaggcta ccgcattcag
    15301 cagatggaag cgggtatgct tgtgcagcat ttattgttgg cggcctccgc tctcgggatg
    15361 ggaggccatc cgctcttagg atttaatgtg agcatgtgcg atgagatata caggttgacc
    15421 cgggaagaaa aaacttgttt gattcaaata ccagtggggt attatcgcca gaggccccgg
    15481 ttggaaggca gtattcatag ttaaataaaa atgccgaggt taatgtacct cggttttttg
    15541 ttgccctttt tttattttta tgtggaaata aagcgccaga tgattaggcg tttttttatg
    15601 ttcaaaaaca ggaggggaca tatggaaatg aaattttcat tgataagtga aaaaatatat
    15661 gctcctctag aaatctttaa aattatagtt gaagtgtgat gaaagaatta acaggaggaa
    15721 ccatgaatgg aggaacaaat ttttaataca gcgctaaata tcgggatatt tggtgctctg
    15781 tttatctggt tgctttttac cacgatgaaa aagaatgaag tgcgggagaa ggagtatcaa
    15841 aagaccatta gtgagaatca ggaagttatc cgagagcaag taaagtcttt tagccttctt
    15901 tcaagtgata tcgccgagat caaaggaatt ttaaaaggaa aacatgaaga ggaagtgttg
    15961 aatgatggaa atcagaaaaa tgttagtaga cccaagtaaa tatggcatta aatgtccgaa
    16021 taaaatggca ccgaaatata tcacctatca taatacggct aatgatgctt ccgcagaaaa
    16081 tgagatccgt tatatgatcg ggaacaataa cgaggtttcg ttccactttg ctgtggacga
    16141 taaagaagct gttcagggca ttccttttga tcgaaatgcc tggcattgcg gagacgggaa
    16201 cggaacagga aaccgtcagt ccatcggcgt agaaatttgt tattccaagt ccgacggtaa
    16261 ccgatattat aaggccgagg acaatgcggc tattgtcatt gccaagctta tgacacagtt
    16321 ttgtattcct attgaaaatg tggtcccaca ccagcactgg agtggtaaat actgcccgca
    16381 cagtggactt ctgtcaatag attggacacc taaaaccgag agaattatgc agctaaacag
    16441 atcatatgtt cgcattgatt gggcgtaaga tacccgatag aggaatggat tctttttcca
    16501 ttgtaaaagc acgtaatgta ctcaaaaatc ttctccttgg cttctttcct ggttttgaat
    16561 ttgtgcaggt aaacgagttc ttttttcagc acgttgtgga acgattcaat acaggcgtta
    16621 tcgtagcaat tgcccttacg gctcatgctg cccgtcatgc cgtattgtcg tagctgcgtt
    16681 tgatagtccg aggacgcata ctggctaccg cgatccgaat gatgcaacac ggttcctttc
    16741 ggccgttgat ggcggtacgc ctgatccaac gccctcaggc agagctccct ggtcattcgc
    16801 tcgcccatgt gaaacccgac gatcttacgt gtgcacaggt cttccagact ggcgagatag
    16861 agccatcctt cgtcagtcgg aatatacgtg atgtccgcca tccagacctg attgggcttt
    16921 tccgcagcaa acgattgatt caagacattt tccgctacgg gcaggttgtg tttcgaattc
    16981 gtcgtcgcct tgtacttctt aacggtacgg gatctcaacc caagttcctt catgatacga
    17041 gcaacggtct tctgagagac gtgaatacct tgttttttca atgcatacca cactttcgga
    17101 ctgccgtaca actgcctgga atcaaagaaa gttctgcgaa tccatcgttc gagttttttg
    17161 cgacgtttga ggcgttcgct ttccttgcgt ttttttggaa acgctgagca gagcgcacat
    17221 cttcgtgaca cggaactgga agcggtgatc atggatgaat ggataaatca gcgccggtct
    17281 tttgcgaagt agtgcatcgc cttttttagg atgtcgttct cctcttctag attgcgaatt
    17341 cgcttctgga ggtcgcgtaa agctttgtcc tccggcttta gttgtccact accagggaat
    17401 gcctggttgc cagcgttctt aaattccgcg atccagcggt aaagcgtgtt ctcatgcaag
    17461 cccatttccc gggctacctg cgccaccgat tttccgtctt cctggataag tcttacggat
    17521 tgaagtttga attccttgtc atactttttc gtcatgtcgg acacctcgat tatgaatgtt
    17581 tttattgtcg cactctcagt tctctgtgtc caatttaaag tcttgcatca tacgaagacc
    17641 aaccgatgga cgagggaact taaaagctac atatacaaag ctatatcaaa tatgggggaa
    17701 taaaatggag tatgagtaca taccaaaacc caataacata ttatcaaaag aagaatattt
    17761 agagaagttt caaacatttt tggaagaatc ctctcgaaat cctgatataa tctgggaagt
    17821 agttagcgat actatggcaa gtctggataa agattttaag ccaaatgcta ccacattggc
    17881 aatatttaaa gaaattcttc cggcattctt aagtaaggaa agtatagact ttctaagata
    17941 catattgaga aatggattac aaaacataga cgaaatgaat aagataaaca ccaaattaac
    18001 tactaaatta catttgctag ttcttaagaa tggaattaat tttagatgtg ctgagaatta
    18061 tttagctaat cctatggcat acgctttact tcagacgtgg ttctcatctt tagataaaga
    18121 agcattatat atgcaaattt taagagctga taaagaatca ttaaatttaa gattagacgt
    18181 ccattctatg tatgctttta caagacactt aattgaaaaa ttaattcaat tactagaaac
    18241 gcacgatata cctgaggaaa gccaacttca acttgtggac agaatgttta gttatttagt
    18301 gaaaagtggt gtgattacta aacatgaata atgaaataaa aaaggaagat gtagtagtcc
    18361 aaattgaatc ttatttgaaa aaaaagggaa aacaagaatt acaatgctta ccttttgaaa
    18421 atgtggatgt tattagtgat tatattgatt ttacctacaa tacatctaga aatacggatg
    18481 ttgacaaaat tcttgagatt tttaaaagta ctagggcaca gacatcttcg actggggagg
    18541 tcggaccgat ggatgaacta aataagtcac tcctagaacg aatggagaga gacataaggg
    18601 aacataggca agaagttgca aatcgtgatt cccgattgca ggcagaaatg caagaacgtg
    18661 aaaaacgtat tcgtgaggac aataaagaaa gagaagagag gatattcaaa gtacttgata
    18721 ctatatccag cgaagtaaag cagataagaa aagaccttca tggtgaaatg aaggaaatga
    18781 aaagtgaact gaacaatgaa gtgagacaca taaggaatga aatatccgat aatacaaagc
    18841 atgtccaaag ccttgttagg caaaaccaat ggggttatat tacagctgta ttagccgtac
    18901 ttgctatatg tgccaccata agttttacag tttgggctgc attaattaaa taaagacgca
    18961 aaagaacctt gaggagtttc ctcaaaggtt cttttgactt tactagggtt tgacactaac
    19021 aatggagtct aaattgttct ttacttacag tagaggatca ataaaggttt cggctcgctg
    19081 aacccattaa tcagcggcca tacgaccagt catttggctg gttttttttg ttttccttaa
    19141 cacaaacggt ctggttgcaa aaatgggttt atcattgcag aatggttgca aaagcataaa
    19201 gaggtgctta tagcggcaga aaaggtgtct tatttcaaaa aggatattag atagacaaaa
    19261 gagtgggcct atattcaggt tcactctttt tttgttttca atactttttt tcatcaatgg
    19321 gtgaaaaaaa gtatgatttc ttagacattt ttaaagttat atttaaagcg aatcgaaagg
    19381 aggattgatg ttcatgtaga cactaaaatg attagtcata catagtaaac ggaatttttg
    19441 agagtctact cgtaaaagac tgccttccga agcaaaaggc ccagaagcga taattacgag
    19501 tgagcaaagc agtagattca acgaatttta tcaaacgcct ttgtggaagc ccgaaagtat
    19561 ctttacaaaa atagataaag gaggaagagg agttatgcaa aatcaaaaat caaacaggtt
    19621 attagcagat ggtatctaca aaattcaagt tgaaaatagt aaagtgtttc aatatgaggg
    19681 gggatctgtt gtcatttcag aatggactgg acaagataat caattatggg aattttatta
    19741 tgttagtaat tggcaagctg ttgatggata ttgcattcga cctgtaggaa caacaaaata
    19801 tcttgcatgg gatagaaata aaggaaacat tttaactgta agggaacatg atcgcgatat
    19861 cgaatacacg aaatactgga agatatatga acttaataat aggtatataa ttgaaaatca
    19921 ccattaccca tttccatatt taaatgtaaa tggggacata gttaatgtgt cacaaggtca
    19981 aaggtacgaa tttactttag ttaaagatcc cgatatacca aatccaaatt ttaatgatat
    20041 atcattagtc attacctcag atccacaata tccttggact ccaaaaatgg atgatggaga
    20101 caacagtgaa agtgatagtg aaacaagaag cgtttctgaa cgtttgataa gagaacaata
    20161 tcaagatatt aattcttata cgaattctgt gccaaattcc tctgttctta taaacggaga
    20221 tattacagct tttgggcatg ggtggcaaag agataaaatg aaaaatttac ttagtacact
    20281 aaataagaaa tattattacg gtttaggcaa tcacgatatt gaaaataata aaaatgattg
    20341 tgctatggat gaatgtttca gagcttcgat gcaagactat caaatccatg ttgatggtca
    20401 taaattaccc aaatctcaag ttgattttga gaaaaaagag tacatgaccg tcctttggta
    20461 tgaaggcagt ttttattata cagtagactt tgggggtata tattccatac aactaaataa
    20521 tttccccaca atgacagcaa gttgtggtat gaatggttat ggaaaaccag gatatactat
    20581 ggaaccaaat cttgattggt tagaacagaa actcaaattt gctagccagt ctggaaaaat
    20641 tattattgta aatgttcata agccagatga ctggaaagga gggcctaatg aaagatttaa
    20701 aaaattatta agagattata acgttacagc cgttttttgt ggtcactatc ataaacaatg
    20761 cggaagaggt tattactctt cttatttcgg tgatgttcct gtctttttat ccggtagcgc
    20821 atcacaaaga acctatttaa ttttggaaca gtctatatat agaaaagaaa taaatattta
    20881 ttcagttaga gataataatt ggaaaaataa aaaattagag cagcgaattg aaatcaatag
    20941 tctcattaac ggtaaatatc aaattgcaac tgctttaaat gacaaaagtg ttttagattt
    21001 gaatggacct aatcatgtta ctctctggga gaataatgga gggagtcatc aaagatggaa
    21061 ctttgtatac gataaaaaga aagaagccta tcagatatat agtgtaagtg ataaaaatct
    21121 agtactagct tggaatgcta tcccaaattc aagacaagtt tttgctacac ctaatcaata
    21181 taaagaagag cattactggc tactagaagc tacaggagat ggttattaca ttattaaaaa
    21241 taaaaaggag cctactttag ttttggatgt tacagattct gaaactgcaa atggaacaaa
    21301 aataaaagta catccgcaac atcctccaac agatgcaata tggaatatta atgctcaaaa
    21361 attcaaattg atataagtat aaaaagactc tgacagttcc tagttgagtc cgtataattg
    21421 tgtaaaaagc taggttccaa aaaatgaaag gagccatatt catagccctc agttagaata
    21481 atgttgggac acaaaattct aaatatacga ggtgttatga aatggctcaa taccagatta
    21541 acgtagattc gcagcttttg catcaactat ttttgggaaa ttctcaggat gcgggtgtag
    21601 ccaagctgct cgagtctgta ctgaaccaag tcttacaagc acaggtgagt gaacaagtgg
    21661 aagcagatcg ttatgaacga acagagaatc gaaaagcgta ccggaatgga tcgtatccac
    21721 atgggctgca tacgcgggtg ggaaccatta cactaagtgt tccgcgcatc cgtggcggga
    21781 agttcacgac agagctcttt agtcgttacc agagaagtga acaagcgtta atcttagcga
    21841 tgatggaaat ggtcgtaaac ggcgtctcta cgcgtaaagt ctcgcaagta accgaagaac
    21901 tctgcggaac cgagttttct aaatccactg tttcagacct ttgtaagcgg ctggatccca
    21961 tcgtaactgc ttggaataat cgaagcctgg cagacagcct ctttccgttt gttctcgtag
    22021 atgcgatgta tctcaaggtc cgtgaagacg gtcgtgtacg ctcacgaggc atcatgattg
    22081 ccattggtgt aaacaccgag ggctatcgtg aagtccttgg cctgatgctg ggtgacacag
    22141 aatctgaagc aagctggagt gagtttttca gctctctaaa aggacgtgga ttacgaggtg
    22201 tggatctcat tacctccgac gatcatggcg gccttgtacg cgcggtacgg cagcagctgc
    22261 aaggggtaac atggcagcga tgccagactc acttcacgcg aaatgtatta gaagcctcac
    22321 ccaaagcctt gaaggatgag atccatggcc gtctacggtc gattctagat gctcctgata
    22381 ctggaacggc aaggttgtta ttaaaacaga ccttagcggc ttatgaagat aaggcgggta
    22441 aggcgatggg cgtgctggaa agcggatttg acgatgctac cgccgtctta atgctgccag
    22501 agcgttaccg aaaacggctg cgcacgacaa atagcgttga gcgtctcaac gaagaggtta
    22561 gacgccggga acgtgtcatt cgcatctttc caaaccgtga atccgtgatt cgtcttattg
    22621 gtgctctatt gatggaacag gatgaaaaat gggcagccgg caagaaatat ctcgacatga
    22681 ccgagtacat ggaatggcgg aaggatcggc caaagtccga tgccaaagtg actcgcatta
    22741 tgtagcacag tctagctgag ggaatttaca cacaaatttg gacttgatcc agttcctttt
    22801 ggataaataa ctcaaatggt actaatattt attgttctaa tgaatagaac ttattcccgc
    22861 cgcccagcta tgctgtggcg gttttttgtt attggttgtg attttcgcgt tttttagtga
    22921 tttggttgta ggcaagattg tcaaggggta ttactttaaa aaccggggac aaaattttga
    22981 aaaagtcttg acaaaagctt tttgcaacca tctcacccaa aagaccatga tttagcaacc
    23041 agatcttttc tattcatcaa tgtgatgatg tcgaacttgt atatttacat aacagggaaa
    23101 tatatggtaa acttctatgc ggtctcttat tttatggaag tgtgagtagt aataggaaaa
    23161 aattattaca taacgaaagg ttggattcta tgagaaaaat aacgaatgtt gtagttttgt
    23221 tcatttttgc agttattagc tttgttactc cctatactca aactgttttt gcagaagaaa
    23281 caaggttaac tttggagaag gaaacagcca tctataatgc tccttctttt tctacgaaaa
    23341 ctatttctac gataagccca caaaaagtaa aggtcttaga aaaaagacca gatggttggt
    23401 ttaaagtagc cacatggcta ggggataagt ggattgcacc taaaggggct gttgtgaaac
    23461 caagaaaaac agaagtattt ctaaggttgt atgaggggcc agatttggat aaaaccacaa
    23521 aatatagttt gtcttacgta aattatgttt tgggacttga tggaactgcc gatggattcg
    23581 tcaagattaa aacggaaaaa ggggatatgt ggatcataga agacacggta cccttacaat
    23641 taacaaaaag tacaccttta tatgattatt cgtggattgg tggtcaaagt attggagtgg
    23701 tatctcctca aaaagtaaaa gtacttgaaa aagatcccta tggactttac agaatcgttt
    23761 cttggctcgg tgaaaaatgg atagcgccac atggagaaaa gtacaaatta acgaaaccaa
    23821 ccgttttata tgatcaccct gccgataata caaaatcagg ctttacccta tccccacaaa
    23881 ccgtgacgtt gttagaattc cgttcgccat ggttttataa gattaatacc tgggttggcg
    23941 aaaagtggat atctacaata ggaactgctt tgagtcgtga taacgatgaa tatattaaat
    24001 acgataattt tcaaacggac agcattttgg aatcagatat gtttgtgaat ctgcaaagct
    24061 ctaaagaagt ccttcagaaa tattatgatg accttgctca atttcaggaa aagttgaatt
    24121 tcattgattg gaatgaattt aggaaacatt ttgagaattt acctgacttt aatttcgatt
    24181 tttcagagtt tgataaatct ttagaagagc tagctaaatg gtcagcgtcc atggatggtt
    24241 attgggaaga ttttaatgca agcattcaac atatgagctc ctccgtggga gaaatcctct
    24301 ctaatattca tattgatact tctaaaatag aagaagctgg tgatatgatt aaaagggcct
    24361 gcgatgaaat aaatgaaggg cttaaaaaaa tgaagtctgg attagatgtc atcaatggtg
    24421 cggtctcgaa cattcatcaa aatcttacgg acatgaatac gggaatgaag caggctcagg
    24481 caggtctcaa taaggcgaac aatgggatga gcgtggcgaa ttcagccata gatcaagcga
    24541 aaaaagccca tgacactcta cagaagtatc ttaaagaccc tattaagatt aaaaaagaaa
    24601 ccagaggctc tgatcttcct aaattaaaaa gcttaggatt tgattttgat tttagttctt
    24661 atctgacgct agaaaacgtc tcagtagcga ttgatttaat tcctattgta ggaaatataa
    24721 aggctggtgg cgaagttata tccggatacg atccgataac gggtgttccc ttagagggac
    24781 ctgactatgt gctaggtatc attggtatta ttgtgggcgg tgaattcaag caggtaggta
    24841 agatcgcagg taaggcaaca gaacttgagg cgaaagcaaa taaaattacg aaatcaatgg
    24901 ttaccaaggt tccgagtgaa attaaattaa gtacaggtaa tatcaaacat ctttggaatg
    24961 gtcattcttt tgaatccttt gcaaaccaaa ttccatattt gatgaaaact aaatcaagag
    25021 acgcggttga aaagcaatta tccaacatta gtttttttaa taaaaatcta agtaaagaag
    25081 aaatcgtctc gtcagttgga aaagcagcaa atgaggcatt aagtaatggt gtaacccatg
    25141 gacaatataa aacaaaaata aatggagaaa taataactgt tgcttttgat aatggtactt
    25201 tccaaactgc ctggggaaca cataattata cactatctga ttttggttat taggaggttt
    25261 ggggttgttt aagctattat ttagatttgt ggatgatgat cttgatgtcc tatcgaagat
    25321 aaatacggaa cagtttgaaa aagaatacgg ggatatattg ggccaaattg agttgaattt
    25381 taatggtaat atagttggat tttttcatga agatgttcct tttggaaatg aaatgattct
    25441 actttggttc aaaagattac atgagactct atttagatta cgaaattcag attacattgc
    25501 gatg
//
