LOCUS       NZ_CP020557            20381 bp    DNA     circular CON 24-JUL-2024
DEFINITION  Paenibacillus larvae subsp. pulvifaciens strain SAG 10367
            chromosome, complete genome.
ACCESSION   NZ_CP020557
VERSION     NZ_CP020557.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus larvae subsp. pulvifaciens
  ORGANISM  Paenibacillus larvae subsp. pulvifaciens
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 4666454)
  AUTHORS   Dingman,D.W.
  TITLE     Paenibacillus larvae genome sequencing
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4666454)
  AUTHORS   Dingman,D.W.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-MAR-2017) Entomology, CT Agric Expt Station, 123
            Huntington St, New Haven, CT 06504, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: FEB-2016
            Assembly Method :: SMRT Pipe HGAP assembly v. February-2016
            Assembly Name                     :: sag10367-hgap-022916
            Genome Coverage                   :: 214.2x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002082155.1-RS_2024_07_24
            Annotation Date                   :: 07/24/2024 02:27:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,275
            CDSs (total)                      :: 5,166
            Genes (coding)                    :: 4,634
            CDSs (with protein)               :: 4,634
            Genes (RNA)                       :: 109
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 532
            CDSs (without protein)            :: 532
            Pseudo Genes (ambiguous residues) :: 0 of 532
            Pseudo Genes (frameshifted)       :: 400 of 532
            Pseudo Genes (incomplete)         :: 184 of 532
            Pseudo Genes (internal stop)      :: 26 of 532
            Pseudo Genes (multiple problems)  :: 72 of 532
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:07:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4202362
            Orig. end                         :: 4222743
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP020557.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Dr. Adriana Alippi,
            CIDEFI-CIC, Facultad de Ciencias Agrarias y Forestales, Universidad
            Nacional de La Plata, 1900 La Plata, Argentina.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20381
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="18"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..20381
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20381
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10381](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10381
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    17..31
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.73"
                     /tool="antismash"
     misc_feature    complement(70..84)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: strong, score: 21.84"
                     /tool="antismash"
     gene            complement(749..1771)
                     /locus_tag="B7C51_RS22595"
                     /old_locus_tag="B7C51_22590"
     CDS             complement(749..1771)
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016200858.1"
                     /locus_tag="B7C51_RS22595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22590"
                     /product="Gfo/Idh/MocA family protein"
                     /protein_id="WP_083041315.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 4.9e-29, bitscore:
                     99.6, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 1.5e-26,
                     bitscore: 91.0, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYKVGLIGCGNIFPMHAASVGLTPEAELAAVCDVKEERASQAGGR
                     YQVPFYTDYKQMIEKEKLDAVHILTPHYLHPQMAIYAASKGVHVLTEKPMSISFEDAEA
                     MVQAAAENHITLGVIFQNRYNPGSQMVKQALSDGSLGRILGAKCFVTWNRSDEYYSHSY
                     WKGTWDKEGGGVIIDQAIHTLDLLRWFVNDEIEYVDAAISNRAHSRIEVEDSAEGVIKY
                     KNGVVTGFWAVNYYSTDAPVEIEIHCEKGIAKMVADRAIIHYNDGTEMSRDKNPDEVID
                     YGEGVKQYWGVSHYKQIKEFYSDLSSGKKPFVDGHEAMKTQRMIAAIYQSGRENKRIFF
                     "
     gene            complement(1948..2127)
                     /locus_tag="B7C51_RS22600"
                     /old_locus_tag="B7C51_22595"
     CDS             complement(1948..2127)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003340413.1"
                     /locus_tag="B7C51_RS22600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22595"
                     /product="hypothetical protein"
                     /protein_id="WP_036654111.1"
                     /transl_table=11
                     /translation="MSEDGPKKISLAEAVKQKLAQKKQEQAKKPSSFHDSGTKVLKTQN
                     NKKPNNQRRRTGGS"
     misc_feature    complement(2208..2226)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 23.76"
                     /tool="antismash"
     gene            2351..3067
                     /locus_tag="B7C51_RS22605"
                     /old_locus_tag="B7C51_22600"
     CDS             2351..3067
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005826659.1"
                     /locus_tag="B7C51_RS22605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22600"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_077995446.1"
                     /transl_table=11
                     /translation="MITLERIHKTYNKTFTAVHYLSLELKPGEIFGFLGPNGAGKTTTI
                     KMITGILEPDEGTIHINGKDVQKEALEAKKQFGYVPDSPDMFLRLKGMEYLNFMGDLYE
                     VPKQKRMDKIEELAKRFNLYGDLTKTIQSYSHGMRQKMVIMGALLHDPAVWVLDEPLTG
                     LDPKSSYVLKEMMREHADSGKTVFFSTHVLEVAEKLCDRVGIINRGRLVFSGTLQEMQG
                     IQNHSSLEQLFLEMTQ"
     gene            3064..4728
                     /locus_tag="B7C51_RS22610"
                     /old_locus_tag="B7C51_22605"
     CDS             3064..4728
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF028259.4"
                     /locus_tag="B7C51_RS22610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22605"
                     /product="hypothetical protein"
                     /protein_id="WP_083041316.1"
                     /transl_table=11
                     /translation="MRTTWTLFWALFKNSGFFLERKNKKEDLKLLLLVLFIVVGLIPLA
                     YLLFSFISNLHEGLAQLGQQGILLGIGITAGSFIVFIFGIYYVMNVFYFAQDVEVLLPL
                     PLRPWQIVTAKFMLALLYEYLTLALLFGPLLIVYGWKGDVGLFYWPYALIIFLALPIIP
                     LLLASFISMFIMRITNISKHKDFFGKIGGILVVALTLGINLGVRKVFNGNLSQEQLESM
                     LQEGSNSFLQLVTRALPTAKYSSLALIESAKVSGLLYLLFNLVITAAIFVCFAYLGEKL
                     YFKGVKGLSESGGKGISLSRKELSSRIRQSSRTFAYMKKELRILYRTPVFFTNCVLQIF
                     IWPVLLFFPVLFQSKDINIHELSLLIQNSNLIAKTLGISLAVMMFLTGAMNVSSTSISR
                     EGRQWVFNKVMPVRVTDLLKGKIAASMALIATGLVMLLTAAWFVLHPPFWLLLLLFVLG
                     LLSGLFSSLTGISIDLRSPKLNWDNEVKAVKQNWNSFFNMMINLAVAGIFLFLTFTFSF
                     SLTVLVILFATVLTGLIAGTAFLLHKYGDRWFHEIEE"
     gene            4871..6325
                     /locus_tag="B7C51_RS22615"
                     /old_locus_tag="B7C51_22610"
     CDS             4871..6325
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019716019.1"
                     /locus_tag="B7C51_RS22615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22610"
                     /product="IS1182 family transposase"
                     /protein_id="WP_083041317.1"
                     /transl_table=11
                     /translation="MLRKTGYEGRSQISMVSLDELVPIDHLVRKIEYAIDFSFIYDLVR
                     DVYCEDNGRPSIDPVVLIKIALIQCLFGVRSMRQTIKEIETNVAYRWFIGYDFSQPIPH
                     FSTLGKNYVRRFRDTGLFEGIFHRILEEAARHGFIEPDVLFIDATHVKASANKNKYVKQ
                     IVQEQSRKYQDQLDEEINQDRALHGKKPFEKKPNVTQKEVKVSTTDPECGLFVKGEKER
                     VFAYSFHTACDRNGFVLGVKVTPGNIHDSQVFEDVLHEVTRVVPAPQAVAADAGYKTPA
                     ICKMLQEQEIRPVLPYTRPKTKEEFFKKHDYVYDEHYDCYLCPANAILSYETTNRAGYK
                     MYRSNPAICQACPFRTQCTESKEAVKRISRHVWAECVEEADHLRHTEENKRIYAERKET
                     IERVFADLKEKHGMRWTTLRGLKRVTMQAMLVFSAMNLKRMATWLWKRGRPSDKFNFVF
                     EIGIKNIKNSRYCSISRDFVFNLDPL"
     misc_feature    complement(6338..6351)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.9"
                     /tool="antismash"
     misc_feature    6338..6352
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 21.38"
                     /tool="antismash"
     gene            6412..7751
                     /locus_tag="B7C51_RS22620"
                     /old_locus_tag="B7C51_22615"
                     /pseudo=""
     CDS             6412..7751
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014459442.1"
                     /locus_tag="B7C51_RS22620"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22615"
                     /product="sodium-dependent transporter"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKTSEQWTSKLGFILAAAGSAIGLGAIWKFPYVVGTNGGGAFFLL
                     FVFFTVAIGLPLLLAEFIIGRSTGKEAVSAYTSIAPGSFWPWVGKIGIVTCFILLSFYS
                     VVGGWILLYLWKSVTGNLLGAEAGYKGMFEGIIADPLLAIGAQVIFMVLTIVVVARGVQ
                     NGIEKTSKYMMPALFLLFLVLIVRAVTLPDAMRGVFFFLSPDFTKINGKSILEAMGQSF
                     FSLSVGASVMVTYSSYLDKKESLSRSAVSIVGLCLMISLLAGFAIFPAVFATGIEPTAG
                     PGLLFIVLPSVFEHIPFGDYFCSYS"
     gene            8097..9994
                     /locus_tag="B7C51_RS22630"
                     /old_locus_tag="B7C51_22625"
                     /pseudo=""
     CDS             8097..9994
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0035673 - oligopeptide transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006857 - oligopeptide transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007477182.1"
                     /locus_tag="B7C51_RS22630"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22625"
                     /product="OPT family oligopeptide transporter"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDRNKKFVPYVPASRSLPELTVLAIVLGIILAIIFAAANAYLGLK
                     VGMTVSASIPAAVISLGILRGIFKRKSILENNIVQTMTTAGEAVAAGAIFTLPALFLWE
                     ANPSQILISFIVLVGGFLGVIMMIPLRRMLIVNEHETLPYPEGTACAEVLISGEEGGKS
                     AVLVLFGFIVGGLVKVLGDGFKLFKTSVETNIAGFKNAVIGMDTYPALLGVGYIIGPRI
                     SGQMFAGGVLAWLVFIPMISFFGASAGMVAPAADKAIGAMSAMDIWSNYIRYIGAGAVA
                     TGGLITLVKTLPMLYGSLRDTFRSFKNKNHGTTNDKVDRTDRDIPALYVVLAAAILIII
                     IAVAPLTDVGFIGAIAIAIFGFLFVMVASRIVGLVGSSSSPVSGMTIATLLIVTFIFKM
                     TGMTGSSGMVAALTVGAIVCTALAVAGDISQDLKTGYLVGGTPWKQQVAMMIGVLVSGL
                     TIGFILSVLHQTYVMGSEQLPAPKAILMKMIVEGIMSNNLPWDLIFIGAGAAVMIEFLG
                     LNSLTVAVGIYLPITTSAPIMVGGLSNGL"
     gene            10001..10381
                     /locus_tag="B7C51_RS22635"
                     /old_locus_tag="B7C51_22630"
     CDS             10001..10381
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009223110.1"
                     /locus_tag="B7C51_RS22635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22630"
                     /product="PqqD family protein"
                     /protein_id="WP_230460694.1"
                     /sec_met_domain="PqqD_RRE (E-value: 9.5e-07, bitscore:
                     26.7, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.7e-11, bitscore: 41.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMSFLKSVRRKTAEDRNLLDMKPMLKDHIRFVSEEDQSRVEIERK
                     NWLERLSVKWMKQPPTRNIHLDPLGAAVIRQCEGTRTVQQIADRVYEEFGEEAEPLLPR
                     LVKFIEIMELNDWLSWKKDEPS"
     aSDomain        10148..10354
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_B7C51_RS22635_PqqD_RRE.1"
                     /evalue="5.30E-09"
                     /identifier="RREFam006.1"
                     /label="B7C51_RS22635"
                     /locus_tag="B7C51_RS22635"
                     /protein_end="118"
                     /protein_start="49"
                     /score="26.7"
                     /tool="antismash"
                     /translation="RLSVKWMKQPPTRNIHLDPLGAAVIRQCEGTRTVQQIADRVYEEF
                     GEEAEPLLPRLVKFIEIMELNDWL"
     gene            complement(10480..11481)
                     /locus_tag="B7C51_RS22640"
                     /old_locus_tag="B7C51_22635"
     CDS             complement(10480..11481)
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009674671.1"
                     /locus_tag="B7C51_RS22640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22635"
                     /product="metallophosphoesterase"
                     /protein_id="WP_023484990.1"
                     /transl_table=11
                     /translation="MRKWMVTCTAALTLLCSSFAFQAEARSERYVSKPKLTFPVISDIH
                     VQSWDSRSHDKFKAALQDLHRINPKADAMVINGDLTDGKIADYTKLKELLKEVPHPGNM
                     FYTIGNHEFYQAWTNADGKWSPDTFPNGITDRESITRFLQFAKQPKVYYEKKVKGYSFL
                     FLGSEQYRQSNPDNLEDAYLSDEQLSWLDHMLENRSKNKKPVFVFLHQPLPDTVSGTSF
                     CCVNNRAVIQHEALKKILSKYSEVFFFSGHTHWELKLPRTLVRDTFTMINSSSVYQLWT
                     ENNAGGETMVDPKESEGLYVEVFEDHVSIKGRDFYRNRWIPEAQFSVPIARK"
     gene            11842..12492
                     /locus_tag="B7C51_RS22645"
                     /old_locus_tag="B7C51_22640"
     CDS             11842..12492
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013672.4"
                     /locus_tag="B7C51_RS22645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22640"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_237088990.1"
                     /transl_table=11
                     /translation="MRQRSDKARRKKIVGRTLLAVVCLLIGIGIYSLFSSVVLSVDAKE
                     HHETPASFPAYEVVNMNKNSPIEYGGVKRKIVYLTFDDGPSPYQGEFLDVLKQNNVKAT
                     FFMVGQNMTPEREANMKRVVEEGHYAGLHSFTHDYKRLYKSGGSANFIEENKKTAALIK
                     KITGSDPHLIRAPYGSAPQIGEAFRGILRTLDLNFGTGLLIRRTGNIWISRLG"
     gene            12722..13366
                     /locus_tag="B7C51_RS22650"
                     /old_locus_tag="B7C51_22645"
     CDS             12722..13366
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021854.4"
                     /locus_tag="B7C51_RS22650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22645"
                     /product="YkyA family protein"
                     /protein_id="WP_023484992.1"
                     /transl_table=11
                     /translation="MDLRKITFSIIAASVIFGLTGCSQPIDHTLSTYSKALEAENNGQD
                     QLVTLAGEEKKGQQTYQLLLEKGKADKKPPEETLKEWKGNIEQRKQLLDQKKTGITQAE
                     ERLKGIDSEIGKIKSGELKEKAVKMNQAYQDRIKTFGDLYGAYEKAFEQEEELVKSFEK
                     VPTDLNEIKTKVTSYNDSYQKVNELKNKLNKETDQFNQAKDSLYQSAVKKG"
     gene            complement(13415..13977)
                     /locus_tag="B7C51_RS22655"
                     /old_locus_tag="B7C51_22650"
                     /pseudo=""
     CDS             complement(13415..13977)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000627269.1"
                     /locus_tag="B7C51_RS22655"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22650"
                     /product="GNAT family N-acetyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNTELQTERLRLCQIKINDAPALFSFWSDPDVTQFMNIAPFQHVD
                     QAVEMIHFLNKLTSERKAIRYSIFLKKTDQIIGSCGFNYFDFENARAEIAYDLGKDFWG
                     KVLLLKLFWLYYIMHITI"
     misc_feature    14103..14118
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 24.74"
                     /tool="antismash"
     gene            complement(14235..15659)
                     /locus_tag="B7C51_RS22665"
                     /old_locus_tag="B7C51_22660"
     CDS             complement(14235..15659)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012371.4"
                     /locus_tag="B7C51_RS22665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22660"
                     /product="serine hydrolase"
                     /protein_id="WP_083041319.1"
                     /transl_table=11
                     /translation="MTTNNCKTWMGLGEWIEARIREWSVPGLAVAVVQKDKVLYSSGFG
                     YRNIEKKLPVNTDTIFGIGSSSKPFAATWLAMLVEEGLLDWDKPIKDYLPDFRMHDDLI
                     TDRITFRDILCHRTGMPNHQLLLVSPSLTEREQIDRLCYLEANEDFRKTWQYSNVMYTM
                     LGFLVESITDTSWEEWTQKRILAPLGMQNTYLTLEEVKQTENYALPYVKVDGQNTEIPF
                     STDVAGTAGALQTSVADLAKWVAFQLNQGNAKENRLISKERLAETHFPNMITGPGKFPE
                     IPFSTYGLGWFIDIFRGHRMIHHSGSIDGFYAHMSFMPDDNIGIVALVNRESTLLTDCI
                     AYHIYDEWLGVKQVDWNERFKQKQKEIDDMVMVTDDLMSSVMEQPEPASLPLKDYTGVY
                     EHPAYEKIEIIMNGDDLSMTFRTFKWELIHDKSNIFLSEAGLPVTFSVNPAGMAKSLQL
                     PLEPTVQEIVFLKKKS"
     misc_feature    complement(16017..16032)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     gene            16091..16276
                     /locus_tag="B7C51_RS22670"
                     /old_locus_tag="B7C51_22665"
     CDS             16091..16276
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009226142.1"
                     /locus_tag="B7C51_RS22670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22665"
                     /product="hypothetical protein"
                     /protein_id="WP_077995435.1"
                     /transl_table=11
                     /translation="MKPAVQEDLVSKYMLQFCYNCEKNHECTTEEHCRHCFAEQGLHEA
                     EHEQNETKRLLHMVYA"
     gene            <16661..16792
                     /locus_tag="B7C51_RS22675"
                     /old_locus_tag="B7C51_22670"
                     /pseudo=""
     CDS             <16661..16792
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012631188.1"
                     /locus_tag="B7C51_RS22675"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22670"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVEPESVFGQMKNNRGFRQFLLRGLAKVSLEVGWLSLAHNLLK"
     gene            17253..17738
                     /locus_tag="B7C51_RS22680"
                     /old_locus_tag="B7C51_22675"
     CDS             17253..17738
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS22680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B7C51_22675"
                     /product="AMP-binding protein"
                     /protein_id="WP_198041786.1"
                     /sec_met_domain="AMP-binding (E-value: 1.5e-35, bitscore:
                     120.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITCSQTVAPGESGQLCVSGVGLARGYLNRPELTAEKFIDNPFIP
                     GEKLYCTGDYARWLPDGNIEYHSRTDHQVKIRGYRIELGEIEAVLQKYTGISEAAVIVK
                     KDRQREPFLSAYYVAKKEIPGHLLRSYMEKRITSLYGSLSFSLYREYAANCERKSGS"
     gene            17808..>17978
                     /locus_tag="B7C51_RS29380"
                     /pseudo=""
     CDS             17808..>17978
                     /NRPS_PKS="Domain: PCP (2-57). E-value: 1.6e-21. Score:
                     68.3. Matches aSDomain: nrpspksdomains_B7C51_RS29380_PCP.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012759.4"
                     /locus_tag="B7C51_RS29380"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="phosphopantetheine-binding protein"
                     /pseudo=""
                     /sec_met_domain="PP-binding (E-value: 3.2e-11, bitscore:
                     41.8, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLAEVWKDVLEVEEVGIHDNFYLLGGDSIKAIQVAAKLYGHQLR
                     MDTKDLMMNPTI"
     aSDomain        17814..>17978
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B7C51_RS29380_PCP.1"
                     /evalue="1.60E-21"
                     /label="B7C51_RS29380_PCP.1"
                     /locus_tag="B7C51_RS29380"
                     /protein_end="57"
                     /protein_start="2"
                     /score="68.3"
                     /tool="antismash"
                     /translation="LAEVWKDVLEVEEVGIHDNFYLLGGDSIKAIQVAAKLYGHQLRMD
                     TKDLMMNPTI"
     misc_feature    18044..18056
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.62"
                     /tool="antismash"
     aSDomain        18044..18670
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B7C51_RS22690_Epimerization.1"
                     /evalue="4.00E-83"
                     /label="B7C51_RS22690_Epimerization.1"
                     /locus_tag="B7C51_RS22690"
                     /protein_end="209"
                     /protein_start="0"
                     /score="271.4"
                     /specificity="E activity: inactive"
                     /specificity="Active site motif: HYLVMDG"
                     /tool="antismash"
                     /translation="MPLSPIQHWFFNKQFTAMHQWNQSVLLYNPEGYDQDILQTVLTKL
                     TIHHDALRMVYTFDHPSPVQINRGLEGNLLGFSTFNVPEQADTGQYIRREMNKLQSRIH
                     LSQGPLVQAGLFRTAEGDHLFLAIHYLVMDGVSFRILLEDLSKTYEQAMHGELVVLPSK
                     TDSYQTWTTRLLEYSASGEFLKEIPYWKEFERKVSSIPLPKDKTAA"
     gene            18044..18736
                     /locus_tag="B7C51_RS22690"
                     /old_locus_tag="B7C51_22685"
     CDS             18044..18736
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Epimerization (0-209). E-value: 4e-83.
                     Score: 271.4. Matches aSDomain:
                     nrpspksdomains_B7C51_RS22690_Epimerization.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012873.4"
                     /locus_tag="B7C51_RS22690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22685"
                     /product="condensation domain-containing protein"
                     /protein_id="WP_198041787.1"
                     /sec_met_domain="Condensation (E-value: 1.4e-47, bitscore:
                     160.4, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLSPIQHWFFNKQFTAMHQWNQSVLLYNPEGYDQDILQTVLTKL
                     TIHHDALRMVYTFDHPSPVQINRGLEGNLLGFSTFNVPEQADTGQYIRREMNKLQSRIH
                     LSQGPLVQAGLFRTAEGDHLFLAIHYLVMDGVSFRILLEDLSKTYEQAMHGELVVLPSK
                     TDSYQTWTTRLLEYSASGEFLKEIPYWKEFERKVSSIPLPKDKTAAVYFISLIIAYIFS
                     VDRLFFMC"
     CDS_motif       18050..18076
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B7C51_RS22690_0001"
                     /evalue="1.00E-04"
                     /label="NRPS-E1"
                     /locus_tag="B7C51_RS22690"
                     /protein_end="11"
                     /protein_start="2"
                     /score="15.0"
                     /tool="antismash"
                     /translation="LSPIQHWFF"
     CDS_motif       18089..18106
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B7C51_RS22690_0002"
                     /evalue="9.90E+01"
                     /label="NRPS-E1"
                     /locus_tag="B7C51_RS22690"
                     /protein_end="21"
                     /protein_start="15"
                     /score="-3.4"
                     /tool="antismash"
                     /translation="TAMHQW"
     CDS_motif       18413..18478
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B7C51_RS22690_0003"
                     /evalue="3.20E-10"
                     /label="NRPS-E2"
                     /locus_tag="B7C51_RS22690"
                     /protein_end="145"
                     /protein_start="123"
                     /score="32.2"
                     /tool="antismash"
                     /translation="LFLAIHYLVMDGVSFRILLEDL"
     gene            18858..19520
                     /gene="sdaAB"
                     /locus_tag="B7C51_RS22695"
                     /old_locus_tag="B7C51_22690"
     CDS             18858..19520
                     /EC_number="4.3.1.17"
                     /GO_function="GO:0003941 - L-serine ammonia-lyase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006094 - gluconeogenesis [Evidence IEA]"
                     /GO_process="GO:0006565 - L-serine catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="sdaAB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014458409.1"
                     /locus_tag="B7C51_RS22695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_22690"
                     /product="L-serine ammonia-lyase, iron-sulfur-dependent
                     subunit beta"
                     /protein_id="WP_079940720.1"
                     /transl_table=11
                     /translation="MKYKSVFDIIGPVMVGPSSSHTAGAASIGKVARTLFGKEPSRIKV
                     SLYGSFAKTYKGHATDVAIIGGILDFDTHDERLPKSMDIARERGIEVKFVEEEAIPNHP
                     NTARIELTGAKDRLELVGISIGGGKIEIIELNGFELKLSGEHPAILVVHNDRYGAIASV
                     TNVLTKHYINIGHMEVSRKEKGKNALMIIEMDQNLDDYIIEEISKLPNILQVTKMVE"
     misc_feature    19913..19926
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     18.25"
                     /tool="antismash"
     misc_feature    19965..19980
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.98"
                     /tool="antismash"
ORIGIN
        1 gatcatgtcc cggcattgaa tgccgttttc aaagataggt tcgggataat ggcgggtaaa
       61 gaaatccaga tcgacatgcg tgatgcggaa cccgcatttt tgatagagag caagttgatg
      121 cacccccgag tttcctgttc ccacttctaa tgatgcggca ccttttttac tggccgtctc
      181 aatggcatga agaaccagct tttttccgat cccctggcct tggaagtcgg gagcgaccgc
      241 cacattgaca agttccagcg tgtccggtct ggtaggcagg agtacataca ctccgacggt
      301 tgaaccatcc agctttgctg tccagcactt tccgcggcta agataattcc ttactctttg
      361 ttcggaaggg tcggcatcca gaagaagttc gaaagggtaa gggtcggatg agggatgggg
      421 ggatattaca agtagggaca tttcatgctt cctcctaatt tctggttaat tttactatca
      481 tttagcctac tgctaagtac ggtctttata ttaatacttt tgtacattgt gtatgggttg
      541 caattagcag ccgcttcatt aagagattga tgatttttca gccccttgta tctcaagtat
      601 gggaacatta tatttatttg gatacctata gttagtaagg ctggtatctg gaatgtggcc
      661 gtattttatt atctatatac ccgtctacag caacaatggc aataagaaaa cacgttcctc
      721 ccagatagag aaacgtgtca ggcaacagtt agaagaaaat gcgtttattt tcccgcccgg
      781 attggtaaat ggcggcaatc atccgctggg ttttcatagc ttcatggcca tccacgaatg
      841 gtttttttcc gctgctgaga tcagaataaa actccttgat ttgcttgtaa tggcttacac
      901 cccagtattg ttttacacct tccccgtaat caatcacttc atcgggattt ttgtccctgg
      961 acatttctgt tccatcgtta taatgaataa tggcgcggtc tgcaaccatc ttggcaatgc
     1021 ccttttcgca gtgaatttca atttcgaccg gtgcatcagt ggagtaatag tttacggccc
     1081 aaaaccccgt tacaactccg ttcttatatt tgatcacgcc ttccgcactg tcttccactt
     1141 cgatccggga atgggcgcga ttgctgatgg cagcgtcaac gtactcaatc tcgtcattca
     1201 caaaccaacg cagcaaatcc aatgtatgaa tggcctgatc aatgattacg ccgccgcctt
     1261 ccttgtccca ggttcctttc cagtagctat ggctgtaata ttcatcggac cggttccagg
     1321 ttacaaaaca cttggcaccc agtatccggc caagacttcc gtcgctaagg gcctgtttta
     1381 ccatttggga accggggttg tatctgttct ggaatataac gcccagagta atatggttct
     1441 ccgccgccgc ttgaaccatc gcttcggcat cttcaaaaga gatgctcatc ggtttttctg
     1501 tcagcacatg tacccctttg cttgcggcat atatagccat ttgggggtgg agatagtggg
     1561 gggttaaaat atggaccgca tccagcttct ccttctcgat catttgctta taatctgtat
     1621 aaaatggaac ctgataacgc ccacctgcct gactagccct ttcctcttta acatcgcaaa
     1681 cagccgcaag ttcagcttcc ggtgtcagcc cgaccgaagc tgcatgcatg ggaaaaatat
     1741 ttccgcaacc aataagtcca actttgtaca taatcagtct ctcccttgct tctacttaag
     1801 atgattaaag catttacatt ctttattcta aggggattcg ggaagtagga acaatggcgg
     1861 tttttgcaaa atttatattg ttttttgcca tgtatcggcc ggagagtccg ggactaactt
     1921 cactgtctta gaaacgcagg gtctttttta tgacccgccg gtccgcctgc gctgattatt
     1981 cggtttcttg ttattctggg ttttcagcac tttagtgcct gaatcatgga atgaggaggg
     2041 cttttttgcc tgttcctgtt ttttttgagc cagtttttgc tttacagctt cggcgagact
     2101 gattttttta ggtccatctt cggacattgt accaccttct tttgaaaaca taaccatact
     2161 taaaacattt cataagttag atttgcacct tggcttatat gaaattgatt ctattgtata
     2221 cacttttatt tacacataca aggggagaat ttcgttatac ttaaagagga ccaggtggga
     2281 attttgacaa taaaatgaac ggtagaaggt tcttaaacgt ataacactat gacgaggagg
     2341 aaaggacagt atgataacac tggaacggat acataagaca tataacaaaa cttttacagc
     2401 agttcattat ttatctctag aattgaaacc aggtgaaatt tttggttttc tcggtcccaa
     2461 cggggcaggt aaaacaacta caatcaagat gattacgggc attttggaac cggatgaggg
     2521 aacgattcac attaacggga aagatgttca aaaagaggca cttgaggcaa aaaaacagtt
     2581 tggttatgtt cctgacagtc ctgatatgtt tttacgcctc aaggggatgg aatatctgaa
     2641 ttttatggga gatttatatg aagtacccaa acagaaaagg atggataaaa tagaggagct
     2701 tgccaaacgg tttaacttgt atggcgacct aaccaaaacg attcagagtt attcgcatgg
     2761 aatgaggcaa aaaatggtga taatgggggc tcttcttcac gatccggcag tctgggtttt
     2821 ggatgagcct ttaaccgggc tcgatccgaa atcatcatat gtacttaaag aaatgatgcg
     2881 ggagcatgcg gacagcggca agacggtctt tttttcgacc catgtcctgg aagtggctga
     2941 gaagctgtgc gacagggttg gcattattaa caggggaagg cttgtattca gcggcacact
     3001 tcaggaaatg caggggatac aaaatcattc ttcacttgaa caattatttc tggagatgac
     3061 gcaatgagaa caacatggac gcttttctgg gcactgttta aaaacagcgg gttttttttg
     3121 gagcgcaaaa ataaaaaaga agacctcaag ttgctgctgc ttgttctctt tatcgtcgtt
     3181 ggacttatac cgcttgccta tctgctcttt tcatttatat ccaatttgca tgaaggactt
     3241 gcccagctcg gacagcaggg cattctcctg ggcataggca taacagcagg ttcttttata
     3301 gtctttattt tcggtattta ttatgtgatg aacgtctttt attttgccca ggatgttgag
     3361 gttttactgc cgctaccctt gcgtccctgg caaattgtaa cggccaaatt catgctggcc
     3421 ttgttatacg aatatttgac tttggccttg ttgttcggac ctcttttgat cgtatatgga
     3481 tggaaaggag atgttggact cttttattgg ccgtatgcgc tgattatttt tcttgcctta
     3541 ccgattattc cgctcctgct ggcctctttt atcagtatgt ttattatgag gattacaaat
     3601 attagcaagc acaaagattt ttttgggaaa atcgggggca tcctggttgt tgcactgact
     3661 ctaggcatta atttgggagt gaggaaggtc tttaacggca atctctcaca agaacagctg
     3721 gaatccatgc ttcaagaagg gagcaattct tttctccagc tcgttacccg ggcacttcca
     3781 acggcaaaat acagttccct tgcccttatt gaatctgcga aagtttccgg actgctctat
     3841 ctgcttttca atcttgtcat aaccgcggct atatttgtct gttttgctta tcttggggaa
     3901 aagctttatt ttaaaggcgt gaaagggctg tccgagtccg ggggcaaagg catcagcctg
     3961 agcagaaagg aactgagcag ccggataaga caaagttcaa gaacctttgc ctacatgaaa
     4021 aaagaactgc ggatcttata ccgtacacct gtatttttca cgaattgtgt tctgcaaatc
     4081 ttcatttggc ctgttttact tttctttccg gtactgtttc aatctaagga catcaatatc
     4141 catgagcttt cattacttat ccagaattcc aatctgattg caaagacttt ggggataagt
     4201 ctggcagtca tgatgtttct tacaggagct atgaacgtaa gcagcacttc gatttcaaga
     4261 gaaggaaggc aatgggtttt taataaggtt atgcctgttc gtgtaacaga cctgcttaaa
     4321 gggaaaatag cagcctccat ggccctgata gctacgggtc ttgtcatgct tttaacggca
     4381 gcgtggtttg tccttcatcc gccgttttgg ctgcttctgc tgctgtttgt tcttggattg
     4441 ctttcaggct tattcagttc gttgacaggg atcagtatcg atttacgttc accgaaattg
     4501 aactgggaca atgaggtgaa agccgtaaag caaaattgga acagtttttt caacatgatg
     4561 atcaacctgg ccgttgccgg catatttcta tttcttacgt ttacgttttc attcagcctg
     4621 actgttcttg tcattttgtt tgctacggtt ttaaccggtc taattgcagg gactgctttt
     4681 ctgcttcata agtatggcga tcgctggttc catgaaattg aagagtagat tcttaagacc
     4741 ccttatgaaa taaggggttc agactgtcga caaagtcctg tcgacagtct tttttacgaa
     4801 aatacaccaa ccattcaccg cattcatata gtatcatata ggtaaataac tagtgcggga
     4861 gtgcttgaat atgttgcgaa aaaccggtta cgaaggacgt tctcaaattt ccatggtctc
     4921 cttggacgag cttgtaccta tagatcattt ggtccgtaaa atcgaatacg ccatcgattt
     4981 tagtttcatc tatgacttgg ttcgggatgt ttactgtgag gataacggcc gccctagcat
     5041 tgatccggtt gttcttatta aaattgcgct tattcaatgc ctttttggtg ttcgctccat
     5101 gcgtcagacc atcaaagaga ttgaaaccaa cgtcgcgtac cgttggttta ttggctatga
     5161 cttcagtcag cccattcctc atttctccac gctgggtaaa aattacgtgc gccgttttcg
     5221 ggatactgga ctgtttgagg gaatctttca tcgcatcctc gaagaagctg cccggcatgg
     5281 tttcattgaa cctgacgtac tcttcatcga cgcgacacat gttaaagcaa gcgcgaacaa
     5341 aaacaaatat gtaaaacaga tcgttcagga gcaaagtcga aagtaccagg atcagcttga
     5401 tgaagagatc aatcaagatc gggctctaca tggaaagaaa ccgttcgaaa aaaagcccaa
     5461 tgtcacgcag aaggaggtga aggtgagcac gactgacccg gagtgtggtt tgttcgtgaa
     5521 gggagagaaa gaacgtgttt tcgcctacag cttccatacc gcgtgtgatc ggaacgggtt
     5581 tgtactcggc gtcaaagtaa cccctggaaa tatccacgac agccaagtat ttgaagatgt
     5641 tctacacgag gttactcgcg tagttccggc tccacaagcg gttgccgcgg atgcaggtta
     5701 taaaacacca gccatctgca aaatgctgca agaacaagag attcgtcccg tcctgccgta
     5761 tacccgtccc aagacgaaag aagaattctt taaaaagcat gattacgttt acgatgagca
     5821 ctacgactgc tacctgtgtc cggcaaatgc catactgtct tacgaaacaa cgaaccgtgc
     5881 tggttataaa atgtatcgct cgaatccggc aatctgccaa gcctgtcctt tccggacaca
     5941 atgtacagag agtaaagagg cagtgaagcg tattagtcgt catgtttggg ctgaatgtgt
     6001 ggaagaggcg gaccaccttc gccatacaga agaaaacaaa cggatttacg cagagcgaaa
     6061 agaaaccata gagcgagttt ttgctgattt aaaggagaag catggtatgc ggtggacgac
     6121 cttacgagga cttaaaaggg tcaccatgca ggcaatgctt gttttttctg ccatgaacct
     6181 caaaagaatg gcgacctggc tctggaagag aggtcgccca tctgataaat tcaattttgt
     6241 atttgaaata gggataaaaa acataaagaa ctcccgctac tgtagtattt cgcgggactt
     6301 tgtcttcaat ctggacccct tatgaaataa ggggttcttt tttttgaaaa tatctagtat
     6361 aatttgggct cagattcggt tttaaaactc aacaatgaat ggagcaaaaa catgaagact
     6421 tcagagcaat ggacttcaaa acttggattc attctggcgg ctgcgggctc ggcgatcggg
     6481 ctgggagcca tttggaaatt cccttatgtt gttgggacaa atggaggagg ggccttcttt
     6541 cttctgtttg ttttttttac ggtggccatt ggacttcccc ttttgctggc agagtttata
     6601 attgggcgtt ccaccgggaa ggaagccgtt tctgcctata catcaatagc tcccggcagc
     6661 ttctggccgt gggtagggaa aatcgggatt gttacttgtt ttattttact ctctttttat
     6721 agtgtggtag gaggctggat tttactttat ctctggaaat ccgttaccgg aaacctattg
     6781 ggtgcggaag caggttataa agggatgttt gaaggtataa ttgccgatcc gctccttgca
     6841 atcggtgccc aagtcatatt catggtgctg acgatcgttg tggtggcacg aggtgtacaa
     6901 aatggcattg aaaaaacaag caaatatatg atgcctgctt tatttttact gtttcttgta
     6961 ttgattgtcc gtgctgttac tcttccggat gcaatgagag gggttttctt tttcttgtca
     7021 cctgatttta ctaaaattaa cggaaaatcc attttggaag ccatggggca atctttcttt
     7081 tcattaagcg tcggggcttc ggtaatggta acctacagtt cctatctgga taaaaaggaa
     7141 agcctgagcc gctcggctgt ttccattgtc gggttgtgtc tgatgatctc ccttctggcg
     7201 ggattcgcga tttttcctgc tgtgtttgcc accggaatag aacctacggc cggacccgga
     7261 ctgcttttca ttgtgcttcc ttctgtattt gagcacattc cgttcgggga ttatttctgt
     7321 tcttattcct gattctgttt ttattcgcta cccttacttc tgcattttct atgctggaga
     7381 ttattgtggc ggcagtggcc aaaggggaaa cgtcccaaag aaaaaaaagg tcatggctta
     7441 tcgggatttg tatcacggca attggcgtgc cgtctgcttt atcttatggc gtcatgcagc
     7501 atgttacctt gttcggaaag actgtgttcg acctgtccga ttatctggtc agcaatattt
     7561 tgcttcctct tggggccttg ctcattgcgt ttttcgtccc gtataaaatc agtaaggatg
     7621 ttctttaccg ggaatttaca atgggttcaa ccaaggctgg aaggtggttt gcagcctggc
     7681 tgtttgcact aagatatatt attcccgttg tcataattct tgtgttctta ggacttcttg
     7741 gacttgtgtg atcttttttc tatcctttta cttatgcact gtggtaaaat aaaatttatc
     7801 tcaaaataga tagaatccat tcctttaaac ggctgggtga gcatttcatt gatagttatc
     7861 aatgatagat ataaaatttt gcatgatccc aatgtggttg agacggtacc agatagtatt
     7921 cgaaatgatt caattttcaa tattatgtca ccaattatcg tttcaattga attattgcaa
     7981 aaatgctcat atagtaaaag cggctcagat tttcaagact ttaaaccggt ccgaatagaa
     8041 agacgagtcg tgaaatggat tcagataaag aatcaaaaga agtgaggaga aaggatatgg
     8101 acagaaataa aaaattcgta ccttacgtcc cggcgtcaag gtcgctgcca gaacttacgg
     8161 tacttgccat cgtattagga attattctgg caattatttt tgcggctgca aacgcgtatt
     8221 tggggcttaa agtaggtatg accgtaagtg cgtccattcc ggctgctgta atttcgttag
     8281 ggattctccg tgggattttt aagcggaagt ccattttgga aaacaacatt gtccaaacga
     8341 tgacgacagc aggggaagcg gtcgcggcag gagcaatttt tacccttcct gctttatttt
     8401 tgtgggaagc caatcccagc cagatactca tcagctttat tgtattagtc ggcggttttc
     8461 ttggtgttat tatgatgatc ccgcttcgcc gtatgctgat tgtaaacgag catgaaacac
     8521 ttccttaccc ggaaggaacc gcttgtgcgg aagtcctgat ttccggcgag gaagggggaa
     8581 aaagcgctgt tttggttcta ttcggtttta tcgtcggcgg gctggtcaaa gtactgggtg
     8641 atggttttaa actgttcaaa acaagtgtgg aaaccaacat tgccggattt aaaaatgccg
     8701 taattggtat ggatacgtat ccggccctgc ttggtgtcgg ctatattatc gggcccagaa
     8761 tttcgggtca aatgtttgcc ggaggggtac tggcctggct cgtatttata ccgatgattt
     8821 ctttctttgg cgcttctgca ggaatggtgg ctcctgcggc ggacaaggca ataggggcca
     8881 tgtctgccat ggatatttgg agtaattata tccgctatat cggggcggga gctgtagcga
     8941 caggcggttt gattaccctc gtgaaaactc tccctatgct atacggatca ctccgcgata
     9001 cgttccgttc gtttaaaaat aaaaatcatg gaacgacaaa tgataaagta gatcgcacgg
     9061 accgcgatat tccagcttta tatgtagttc ttgccgcagc aattctgatt attatcattg
     9121 ccgtagcgcc tttgacagat gtcggattta tcggagccat tgctattgcc atctttggat
     9181 ttctttttgt aatggttgcg tcccggattg taggcttggt cggaagttca tcctcgccag
     9241 tatccggtat gactattgct actttattga ttgttacgtt tatcttcaag atgacaggca
     9301 tgacgggttc gagcggtatg gttgctgctt tgactgtagg tgctatcgtt tgtacagcac
     9361 tggctgttgc cggggatatt tcccaggacc tgaaaacagg gtacctcgta ggcggaactc
     9421 cttggaaaca gcaggtggcc atgatgatcg gggtcttggt ttccgggctt acaatcggct
     9481 ttatcctctc ggtactgcat caaacttatg taatgggctc agaacaactt ccggcaccta
     9541 aggccatttt aatgaagatg atagtagagg gcattatgtc gaataacctt ccatgggatc
     9601 tgatctttat cggggcaggc gctgctgtga tgatcgagtt ccttggactg aactctttga
     9661 ctgttgcagt cggtatttat ctgccgatta caacaagtgc ccctattatg gttgggggct
     9721 tgtcaaatgg cttgtagatt tccgcaacag gaataaggca ccggaactgg tgaagtcccg
     9781 tgaagaaaca ggaattctgt ttgcatcagg tcttatcgca ggggaatctc tcctaggtgt
     9841 ggttattgcc attatcattt ggctggctcc aaatgcaatt ggggataatc cgctcttcac
     9901 aaacaacctt cttccaacag ttgtcttcct attcgttgta gctttgctct actttgtaat
     9961 tatgagagct aaacaagtca agaccgggaa ataggtggaa atgatgagct ttctaaaatc
    10021 agtgagaaga aaaaccgcag aagaccgcaa tcttctggat atgaaaccaa tgttaaaaga
    10081 tcatatccga ttcgtttcgg aggaagacca aagccgtgtc gagatcgaac gcaaaaattg
    10141 gctcgagcgc ttatctgtta aatggatgaa gcagcctccg acccgcaata tccatctgga
    10201 cccgttggga gcagcagtta tccggcagtg cgagggaacc cggacagtac agcaaattgc
    10261 tgatcgggtt tacgaagagt ttggtgaaga agcagagcct ttgcttccac gtttagttaa
    10321 atttattgaa attatggaac ttaatgactg gctttcttgg aaaaaggacg agccttcata
    10381 aagaactgga caaagcccgc tgagacttaa ctcagcgggc ttttagtatg gcgaattcgt
    10441 taaatgtcac attactgctg tttgagtagg ggggaatcct tattttctag ctataggcac
    10501 tgagaattgg gcttccggaa tccaccggtt ccggtagaaa tctcgtccct tgattgaaac
    10561 gtgatcctca aagacctcga cataaagccc ctcactttct tttgggtcta ccatcgtttc
    10621 tcctcccgcg ttattctctg tccacaactg atagaccgaa gaagagttta tcatcgtgaa
    10681 cgtatcccgg accagcgttc ggggcagttt caattcccaa tgtgtatgac cactgaaaaa
    10741 aaatacttcg gagtatttgg aaagaatctt tttgagtgct tcatgttgta ttaccgcacg
    10801 gttgtttaca cagcaaaagg aggttccgga tacggtatcc ggaagaggtt gatgtaaaaa
    10861 cacgaagaca ggttttttgt ttttgcttcg attctccaac atatggtcaa gccagctaag
    10921 ctgctcatcg gataaatagg catcctcaag attatcaggg ttagactgcc tatattgttc
    10981 ggacccaagg aaaagaaacg aatagccctt tacttttttc tcgtaatata ctttgggctg
    11041 ctttgcaaat tgtaggaacc gggtgatcga ttcccgatct gtgattccat taggaaacgt
    11101 atccggactc cactttccgt cagcgttcgt ccaagcctga taaaactcgt gattcccgat
    11161 agtatagaac atattgccgg gatgagggac ctccttcagc agttctttga gttttgtgta
    11221 atccgctatt tttccatccg tcagatcccc attgatcacc atggcgtcag ctttgggatt
    11281 aatgcggtgt aaatcctgca gggccgcctt aaatttatca tgcgagcggc tatcccagga
    11341 ttgaacatgg atgtcgctaa tgaccgggaa agtcagtttg ggcttggata cgtatctttc
    11401 agaccgggct tcagcttgaa aagcaaagga agagcataat aaggttaatg ccgccgtaca
    11461 agtcaccatc cattttctca tgacctgagt ctcctttctt cttcaacctt taaacactcc
    11521 cccgctgctc ctgtattctc acctcctttt cataaaaata ccataaatta ccatacatta
    11581 ctatagtcaa gaatagatta atagattatg ttttgcggct aaagtttcat ataagaacca
    11641 tggggtctga acaccctccg tgcagcacgg cacgccggaa gagacgggcg ccaggaaaaa
    11701 aacggtgagc gtaacattca ttcatccttg tcgaacattg taacttggtt gtaacgatcc
    11761 ttttttttat gtgtagtaga gtaggaaatg agtttactag ttacatagat tgaataataa
    11821 aacaaaaaga aggtagattt catgagacaa agaagtgata aagcaagaag gaaaaaaata
    11881 gtgggacgta ctttactggc tgtagtatgt ctgctaatcg ggatcggtat atattcctta
    11941 ttttcatcag tcgttctatc cgtagatgcc aaagaacatc acgaaacacc ggcttctttc
    12001 cccgcttatg aggtcgtgaa tatgaataaa aattctccca ttgaatacgg cggggtaaaa
    12061 cgtaaaatcg tatacctgac tttcgacgac ggaccgagcc cgtatcaggg ggaattcctg
    12121 gatgttttaa agcaaaataa cgtgaaagcc actttcttta tggtaggaca aaatatgacg
    12181 cccgaacggg aagcgaatat gaaacgggta gtggaagagg gtcattatgc gggtcttcac
    12241 agctttaccc atgattataa gcgtttgtat aaaagcgggg gatcggccaa ttttattgaa
    12301 gaaaacaaga aaactgcagc attaataaaa aagataaccg ggtctgatcc ccacttgata
    12361 agagcacctt acggcagcgc tccgcaaatc ggggaggcat tccgggggat attgcgaacg
    12421 ctggatttaa actttgggac tggactattg attcggagga ctggaaatat ttggatcagt
    12481 cggctaggat aatgaacaat gtgattccca atcttcaccg cgatgtggaa gtcatcttgt
    12541 ttcatgagaa aaaaacaaca ctagacattt tgccacaaat aatacatgat attcgggcca
    12601 aaggttatga gtttgaagca tacaacgaaa aggagcattt ccccttaaac ttccatcatg
    12661 ataaccgcct ctagttaaaa cagtatagtg gatcaaagaa agtagaaaag aggagattag
    12721 cttggactta cggaaaatca cattcagcat aatagcagca tcagtaatat ttggtttaac
    12781 aggctgctcg cagcctatag atcatacttt aagcacttac tcgaaggctc tggaggccga
    12841 aaataatggc caggatcagc ttgtaacgct ggccggggaa gagaagaaag gccagcaaac
    12901 gtatcagctt cttttggaaa aagggaaagc ggacaaaaaa ccgccggaag aaacattgaa
    12961 agaatggaaa ggaaatattg aacaaagaaa gcaactgcta gaccagaaaa aaacaggcat
    13021 tacacaggcg gaagaaagac tgaaaggcat tgatagtgag atcggcaaaa ttaaaagcgg
    13081 ggaattaaaa gaaaaagctg taaaaatgaa tcaggcttac caagatagaa taaaaacttt
    13141 tggggacctt tatggagctt acgagaaagc ctttgaacaa gaagaagagt tagtaaaaag
    13201 ctttgaaaaa gttcctaccg acttaaatga aatcaagact aaggtaactt cttataatga
    13261 ttcttaccag aaagtaaacg agcttaaaaa taaactcaat aaagaaacag accagtttaa
    13321 ccaagccaaa gattcactct atcaatctgc tgttaagaaa ggatagatag aagagcccat
    13381 aaatcggata ttgttttatg gctctttttt tactttagtt acgattccat tgacttgcgc
    13441 attcagtata ctcgtttttc aattttgaat acatgtgaag gtcaataaag tttcttctgg
    13501 atttctcgta ttgtcttaat gtaccctcaa atgaaaaacc gagtttattc agaagtttga
    13561 tcgagttctt attctggggt tctacttttg cttcaattct gtttaggttt aaatcgttat
    13621 atgcataatg taataaagcc agaacagctt caggagcaaa acctttcccc aaaaatcttt
    13681 gcctaaatcg taggcaattt ccgctctggc gttttcaaag tcaaaataat taaagccaca
    13741 agaaccaata atctgatccg tctttttcaa aaatatagaa taacggattg ctttacgttc
    13801 tgacgtcaat ttattcagaa aatgaatcat ttccactgct tggtcaacat gctgaaacgg
    13861 tgcaatattc ataaattgtg taacatcagg gtcagaccaa aaagaaaata aagcgggtgc
    13921 atcgttaatt tttatttgac aaagtcttaa tctttctgtt tgcaattcag tattcactaa
    13981 ttatatcctc cgtttgttta tagtttggat tgagtatatg aaaatggtac caggtattgt
    14041 ttattccttt ctgtaaaacg tgcttatata ctattttagc ataccatttt atcttatgtc
    14101 ttttaacaat attttcacgg attccaaagg ggacgtaagc tcttcgggat atatcccgcc
    14161 tctgtttaca agccatttgc tccttatatg gtttctaaac agtttaaagc ggccggttag
    14221 accgcttttt tctttcagct tttctttttc aaaaaaacaa tctcctgtac agttggttcc
    14281 agaggcagtt gtaagctttt ggccattccg gcggggttca ctgaaaatgt tacaggcagt
    14341 cctgcctcgg aaagaaaaat gttactctta tcatgaatta actcccactt gaaggttcgg
    14401 aacgtcatgc taaggtcatc accattcatt atgatttcta ttttttcgta tgcagggtgc
    14461 tcatagactc cggtatagtc cttaaggggc agggaagctg gctctggttg ttccataaca
    14521 gatgacatga ggtcgtctgt taccattacc atgtcatcaa tttccttttg tttttgctta
    14581 aaacgctcat tccagtccac ttgtttcaca cccagccatt cgtcataaat atggtaagca
    14641 atacaatccg tcaaaagtgt cgattccctg tttacgagag ccacaatacc aatgttatca
    14701 tcgggcataa aagacatatg agcataaaaa ccgtcaatac tgcctgagtg gtggatcatg
    14761 cggtgtccac ggaatatatc aataaaccag ccaagcccgt aggtagagaa ggggatttcg
    14821 ggaaatttac cgggacctgt gatcatgttc gggaaatgtg tttccgccag cctctctttt
    14881 gaaataagcc tgttctcctt agcattacct tggtttagct ggaaggcaac ccatttcgcc
    14941 aaatccgcga ctgaagtctg caatgccccg gcagtacccg ctacatctgt cgaaaaagga
    15001 atttccgtat tttgtccgtc tacttttaca taaggaaggg cataattttc tgtctgtttt
    15061 acttcttcca aggtcaggta agtattctgc atgccaagtg gggcaagtat ccgcttttgt
    15121 gtccattctt cccatgaggt atccgttatg gattctacca aaaaaccgag catagtatac
    15181 ataacgttag aatactgcca tgtttttcga aaatcttcat tcgcttccaa atagcataat
    15241 cggtctattt gttctctttc cgtcaatgaa ggacttacca gcaaaagctg gtgattgggc
    15301 attccggtac gatggcagag aatatcccga aaagttatcc gatctgtaat tagatcgtca
    15361 tgcatacgga aatccggtaa gtaatcttta ataggcttat cccaatccaa tagaccttct
    15421 tctacgagca ttgcgagcca cgttgcggcg aacggctttg acgatgagcc gattccaaag
    15481 atcgtgtccg tattaaccgg aagcttcttc tctatattcc tgtaaccaaa accggaacta
    15541 taaagtactt tatccttttg tactacagca accgctagtc cgggaacgct ccattcgcga
    15601 attctggctt cgatccattc tccaagtccc atccaagttt tgcagttgtt tgtggtcatg
    15661 tgtttttcct cctagtaaaa attatgatat aatatctaac aaaccgaata tccggtcagt
    15721 atgtaaatcc aagagccgtt aatcgaactg gattatattg aaaagctaag aagttggaac
    15781 ctgactcttt tacataccga acgttcagtc aattaaatca tataccatct tttatgcaga
    15841 gtcaattttt tagctgccat tttataaaaa ttcaagtaaa ataggcattg tagaatctat
    15901 ccgaaaaatt gaaacttatg agggaagatc atctggtttg gaagcctcag acaaataagc
    15961 ggaaccttat tcgcgctttg aatggctgct tcagattctt tcccatcttt taagaatgtg
    16021 aaaaaaatca catataatat ttgaaatgta tgttaatcta tagatgtaaa gaagaaaagg
    16081 agtgattaaa atgaaaccag ctgttcaaga agatttggta agcaaatata tgcttcaatt
    16141 ttgctacaat tgtgaaaaaa atcacgaatg tacaacggaa gaacactgcc gccattgttt
    16201 tgccgaacaa gggcttcatg aagcagaaca cgaacagaat gaaaccaaac gattgctcca
    16261 tatggtctat gcttaatgag ctgcatctaa gaatcgttca gtcttatata gaattttctg
    16321 gaattgccct tcccgccttt ttagcagaat ttaagtcagc tgaaaaggtt ttttcttgtt
    16381 tggggtggcc ttgataaaca atgaatttgt tcgatgattg acaattctac aggaacaggc
    16441 gctccggcta tagacgggag aacgaaaggt gacaccgcgg gtaaggggct gtcccaaaat
    16501 attggaaatg acagaagagg gatgattctt ttctcaagat tgtaaaacaa tagaaaaccg
    16561 ttctttagta aaatggaagt gacacccacc atttacgaaa ggaacggttt ctttgtatat
    16621 tcaatagaaa aactgcgcag tgaaaaagga tacgctttgt atggtagaac cggagagtgt
    16681 attcgggcaa atgaaaaata accggggatt cagacaattc ctgcttcgcg gcttagcgaa
    16741 agtaagcctg gaggtcgggt ggctttcgct tgcccataat ctgctcaagt gacagacgat
    16801 gaaccaaaaa ggtcgagttc gagagccaat atgagctctg actcgacctt tttgtacaaa
    16861 tcaagttgat ttataagccg tggctgtttc acagcagtta aaaactaacc agctttatcc
    16921 ccccgttctt tctgagcccc aaggaagcaa cctatgtgaa tttcagaact atcttggaga
    16981 aaactcgatt acagttatga ctctgccgcc ttcctatgct caatacctgg atccggtatc
    17041 cctttttgat ctaaggttac tcattacagc cggttccgca tcatcacaga atttagtcaa
    17101 caagtggaat caaagcgtta cttatgtaaa tgcatatgga ccaacagaaa caagcatatg
    17161 tgctacaacc tgaaccgcac caaggcaatg gtgtcaggca agtcatatcc ctattggtgc
    17221 gccaattcgt aatacgcagg tatatatttt ggatgataac ctgcagccag acggttgcac
    17281 ccggtgaatc cggacagcta tgcgttagcg gcgtcggatt agccagggga tatttgaacc
    17341 ggccggaact gactgctgaa aagtttatcg ataacccgtt tattcccggt gaaaagttat
    17401 attgtacggg ggattacgcg aggtggctgc ctgacgggaa tatagaatat cacagcagaa
    17461 cggaccatca agtgaaaatt agggggtacc gcatcgaact gggtgagatt gaagcggttc
    17521 tccaaaaata taccgggatt tcagaagctg cagtgatcgt gaaaaaagat aggcagaggg
    17581 aacctttttt gtccgcctat tatgttgcaa aaaaggaaat acccggacat ttactgcgct
    17641 cttatatgga aaaacgaatt acctcattat atggttcctt atcattttca ttgtatagag
    17701 aatatgccgc taactgtgaa cggaaaagtg gatcgtgaga aactgcttct gtctgaatat
    17761 aaccaagaag ctgctgccca gtatacagcc cccgtaatga gctggaattg ctgctggctg
    17821 aagtatggaa agatgtcttg gaagtagagg aggtgggaat ccacgataat ttctacctgc
    17881 ttggcggaga ctccattaaa gctattcagg tggctgccaa attgtacggg caccaattaa
    17941 ggatggatac gaaagacttg atgatgaatc cgacaattag tacccttgcg cctgtcatag
    18001 cctttattga acaagaatgc gaccaggggt cgtgcaagga gaagtgccac tgtcccctat
    18061 tcagcattgg ttcttcaata aacaattcac ggccatgcat caatggaatc agtcggttct
    18121 gttatacaat ccggaggggt atgaccaaga cattctgcag acggtactaa cgaaactgac
    18181 catccatcat gatgcattgc ggatggtata tacatttgac catccatcac ctgtgcagat
    18241 aaacagggga ctggaaggga atttgttagg tttttctact ttcaatgttc ctgagcaagc
    18301 tgatacgggg caatatatcc gccgggaaat gaacaaattg cagagccgta tccatttatc
    18361 gcaggggccg ttagttcagg caggcctgtt ccgtacggcg gaaggtgacc atttgttttt
    18421 ggccattcat tacctggtta tggacggcgt ttcatttcgc atattgctgg aggatctgtc
    18481 caaaacatat gaacaggcca tgcatgggga attggtggtt ctcccaagta aaacagattc
    18541 ttaccagact tggacaacca ggttattgga atactccgct tccggcgagt ttcttaagga
    18601 gattccatac tggaaagaat ttgagcgcaa agtatcgtct attcccctgc ctaaagacaa
    18661 aacagctgct gtgtatttta taagcttaat tatcgcttac atattctctg ttgaccggct
    18721 atttttcatg tgttaggctt cttaagaaac ggtattttca aggttgcgca aaaaagaatt
    18781 acagaagata ataaaaaaga agcaaataaa tggataacat tatggcagat gtgccaagct
    18841 taaagaggtg catacggatg aaatataaaa gtgtgttcga tattatcggg cccgtaatgg
    18901 taggaccttc cagttcgcat accgccggtg ccgccagcat cggaaaagtg gcccggactc
    18961 tttttggaaa agagccgtcc cgcatcaaag tatcgttata cggttccttt gcaaaaacct
    19021 ataaaggaca tgctactgat gttgccataa taggggggat tctggatttt gatactcacg
    19081 atgaacgtct gccaaaatct atggacattg cgcgagaaag aggcattgag gttaagtttg
    19141 ttgaagagga agccattccc aatcatccca atactgcacg tattgaattg accggtgcta
    19201 aggaccgact ggaactggtt ggaatatcca taggcggcgg gaagattgag atcatagagc
    19261 ttaacggatt tgaactcaag ctttcaggcg aacaccccgc aattctggtg gtccataatg
    19321 accgctacgg ggcgattgcc agcgtaacga atgtactgac caagcattat attaatatcg
    19381 gtcatatgga ggtatcccgc aaggagaagg gaaaaaatgc tctgatgata attgagatgg
    19441 accagaatct ggatgattat atcattgagg aaatcagcaa attgcccaat attttgcaag
    19501 tgacgaagat ggttgaatag cctaaagata agcagagggg atatgtatgt ttcggaatgt
    19561 ggctgaactt gtagagcagg ctgaacaaga gcaagtgaaa atcgccgaga tcatgatccg
    19621 gcaggaaata gaggtatcag gagtgacccg tgagcaaatc atggccaaaa tggaccggaa
    19681 tctgacagtc atggaacagg ctgtggaaaa aggtctgcag ggtgtgcgtt ccttgtccgg
    19741 cctgaccggc ggggatgctg ttctgctcca gaattatatc cgttccggta aaagtttgtc
    19801 aggcgagctg ctgttggatg cggtcagcaa agcggtagct accaatgagg tgaatgccgc
    19861 catgggaacg atttgcgcga ctccaaccgc gggttcggcc ggcgtggttc cgggcacatt
    19921 gtttgccatt aagcacaagc tgaatccgac ccgggaagaa atggtcgaat ttctgtttac
    19981 ggcaggggca ttcgggttcg tggttgccaa taacgcatcc atctcaggag ctgccggagg
    20041 atgccaggcg gaagtgggtt cagcaagcgg tatggcggcg gcatccattg ttgaaatggc
    20101 gggcggcagc cctgcccagg ctgcggaagc catgacaatt accttgaaaa atatgcttgg
    20161 acttgtctgt gatccggttg cgggccttgt agaagttccc tgtgtcaaac gcaatgcgat
    20221 gggagctgcc aacgcgatgg tagcggccga tatggctctg gccggaatta caagccggat
    20281 tccttgtgat gaagtcatcg gggccatgtt ccggatcgga cagacgatgc ctgtagggct
    20341 tcgggaaact gctcttggcg gcctggcaac tacgccgaca g
//
