LOCUS       NZ_CP020557            20771 bp    DNA     circular CON 24-JUL-2024
DEFINITION  Paenibacillus larvae subsp. pulvifaciens strain SAG 10367
            chromosome, complete genome.
ACCESSION   NZ_CP020557
VERSION     NZ_CP020557.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus larvae subsp. pulvifaciens
  ORGANISM  Paenibacillus larvae subsp. pulvifaciens
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 4666454)
  AUTHORS   Dingman,D.W.
  TITLE     Paenibacillus larvae genome sequencing
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4666454)
  AUTHORS   Dingman,D.W.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-MAR-2017) Entomology, CT Agric Expt Station, 123
            Huntington St, New Haven, CT 06504, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: FEB-2016
            Assembly Method :: SMRT Pipe HGAP assembly v. February-2016
            Assembly Name                     :: sag10367-hgap-022916
            Genome Coverage                   :: 214.2x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002082155.1-RS_2024_07_24
            Annotation Date                   :: 07/24/2024 02:27:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,275
            CDSs (total)                      :: 5,166
            Genes (coding)                    :: 4,634
            CDSs (with protein)               :: 4,634
            Genes (RNA)                       :: 109
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 532
            CDSs (without protein)            :: 532
            Pseudo Genes (ambiguous residues) :: 0 of 532
            Pseudo Genes (frameshifted)       :: 400 of 532
            Pseudo Genes (incomplete)         :: 184 of 532
            Pseudo Genes (internal stop)      :: 26 of 532
            Pseudo Genes (multiple problems)  :: 72 of 532
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:07:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3408582
            Orig. end                         :: 3429353
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP020557.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Dr. Adriana Alippi,
            CIDEFI-CIC, Facultad de Ciencias Agrarias y Forestales, Universidad
            Nacional de La Plata, 1900 La Plata, Argentina.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20771
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="16"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     cand_cluster    1..20771
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20771
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10771](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10771
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     gene            complement(209..433)
                     /locus_tag="B7C51_RS29215"
     CDS             complement(209..433)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS29215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_367869836.1"
                     /transl_table=11
                     /translation="MTVNTIVVPCMILFSLLVVATTWGTPGSGNWLRITTDFSPVYSWL
                     SPFLYTSFNLATAQAVLVPLGPRFRTEKF"
     gene            complement(483..848)
                     /locus_tag="B7C51_RS29220"
     CDS             complement(483..848)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS29220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_313778443.1"
                     /transl_table=11
                     /translation="MKRHIQVLQIAFTYVGTVVGAGFASGQEILQFFTRYGAVATGTIL
                     LSTILFIGVGIKLMLLSREVRAKSYEDMIRYLFGAKAGKWVALFSLLVLLGVSIVMLAG
                     GGLCLKNSLELILKWGL"
     gene            966..1610
                     /locus_tag="B7C51_RS18240"
                     /old_locus_tag="B7C51_18235"
     CDS             966..1610
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1188: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009674770.1"
                     /locus_tag="B7C51_RS18240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_18235"
                     /product="DedA family protein"
                     /protein_id="WP_023483886.1"
                     /transl_table=11
                     /translation="MITYWEWLNLKETVFSLLADYGYYALYSLLALGIIGLPIPDETLM
                     AFVGSMTMHGGPMNFWASLAVAYAGTMTGMTISYTVGRKVGKPFLYKYGKWMKLTPARL
                     QKAENWFRKYGLWTVGFGYFVPGVRHFTCYLAGMSGVKWWKYLLYAGSGALVWCVTFLL
                     LGRWIGRNFDRVLHMFHRYTGVTLGILGGLLILGLIVYLVFKRKKKQRNHM"
     gene            complement(1768..2730)
                     /locus_tag="B7C51_RS18245"
                     /old_locus_tag="B7C51_18240"
     CDS             complement(1768..2730)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1026: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF033516.0"
                     /locus_tag="B7C51_RS18245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_18240"
                     /product="IS3 family transposase"
                     /protein_id="WP_158530429.1"
                     /transl_table=11
                     /translation="MRSTERVFRNGERSGKKVGRDPATTYTLTLVRHADWYQAIQELHA
                     EKGYAVTKLCKLAGVARSAYYKWLKWKPSIRELEILSLAKEVKLRYDKRKGVLGYRQIR
                     TQLNRKLKKSYNKKRYYRIMRALELKAVIRRKRPNYVKSSAIHVAENVMNREFHADSPN
                     LKWCTDVTELKYGNGRKAYLSAIVDVYDNSIVSWVLSPSNNKKLVMDTVNKAYWRNPGV
                     TPLLHSDRGFQYTSHEYSLLQLKYGFTKSMSRVSRCLDNQPIERFWGTFKAESFYLRKH
                     DTYEDVLKDVRNYIHYYNNYRYTERLSGLSPSEYRKQAA"
     gene            complement(2646..3044)
                     /locus_tag="B7C51_RS18250"
                     /old_locus_tag="B7C51_18245"
     CDS             complement(2646..3044)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013677.4"
                     /locus_tag="B7C51_RS18250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_18245"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_158530430.1"
                     /transl_table=11
                     /translation="MTRWISKYTNGVEIKSTRKGIGLSRMNKGRKTTFEERIEIAQYTI
                     ANDLDYQKSIEKYDVSYSQVYAWVRKYKSGGEEALKDNRGRNKPAEELDDHERLKLRIK
                     ELEARNEYLEMENALAKKLAEIRRRHTR"
     gene            complement(3041..3334)
                     /locus_tag="B7C51_RS18255"
                     /old_locus_tag="B7C51_18250"
     CDS             complement(3041..3334)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024908.4"
                     /locus_tag="B7C51_RS18255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_18250"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_198041755.1"
                     /transl_table=11
                     /translation="MSKRSPTSLEVKLRVVKRCLQNETNPNYEAKQLGIDKNTVTDWVR
                     KYKADGLDGLKESRGCKAYSEDLQLAAIRDVLSGSHSIREATKKYHISSKMF"
     gene            complement(3426..4070)
                     /locus_tag="B7C51_RS18260"
                     /old_locus_tag="B7C51_18255"
     CDS             complement(3426..4070)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS18260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B7C51_18255"
                     /product="hypothetical protein"
                     /protein_id="WP_083041039.1"
                     /transl_table=11
                     /translation="MIHQSRFTLAILTSIVITILAGCGNTGESAKPVSTQEQTVQPEYS
                     DSSSSASRQSTSRTFISSQSNNEPFVDPKADNPPLHVNEQDQFTPAKPALLGLQPGMDI
                     LEVMDKLGKAKSFFKMEETRNPVTVYEYADFSVGFNGNRKLKFVEIKNDKINPGLHGVK
                     IGSSTKDAVNTLGLPSTKTSYVLAYESGGTILRLDVDPKLDQVLSIKLFKE"
     misc_feature    complement(4308..4321)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.71"
                     /tool="antismash"
     gene            4416..4742
                     /locus_tag="B7C51_RS18265"
                     /old_locus_tag="B7C51_18260"
     CDS             4416..4742
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010499765.1"
                     /locus_tag="B7C51_RS18265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_18260"
                     /product="hypothetical protein"
                     /protein_id="WP_036655089.1"
                     /transl_table=11
                     /translation="MGNETLPNDYLIEKLSEAKTLFERSLDCKHTEFDDLYPYMIEHPQ
                     FFWYKRYVAWSELLTVVKICSELSVPWKQTFTSQQVQYIENRVMSSKVLDEWFERNDSK
                     EHVG"
     gene            complement(4869..5177)
                     /locus_tag="B7C51_RS18270"
                     /old_locus_tag="B7C51_18265"
     CDS             complement(4869..5177)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009674764.1"
                     /locus_tag="B7C51_RS18270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_18265"
                     /product="hypothetical protein"
                     /protein_id="WP_036655087.1"
                     /transl_table=11
                     /translation="MVDKKKYYLTVASGDIVENKEDTNYDFEIYASPEELDQLQVLFEE
                     LYSADISTHFRALIPFKEYHSDEENDRYDRGLKNIYELVHRLGTKETKETIEHMNIL"
     gene            5570..5803
                     /locus_tag="B7C51_RS18275"
                     /old_locus_tag="B7C51_18270"
     CDS             5570..5803
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009674782.1"
                     /locus_tag="B7C51_RS18275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_18270"
                     /product="hypothetical protein"
                     /protein_id="WP_024095020.1"
                     /transl_table=11
                     /translation="MISDEQLDDYRIKGKKLRVIRDADPANDVKGIVVAWDEQHVLIRK
                     QNRNIVKLSRSYTYQPFEAERPGEFTLPDKGE"
     gene            5875..6588
                     /locus_tag="B7C51_RS18280"
                     /old_locus_tag="B7C51_18275"
     CDS             5875..6588
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014060.4"
                     /locus_tag="B7C51_RS18280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_18275"
                     /product="adenosylcobinamide amidohydrolase"
                     /protein_id="WP_083041040.1"
                     /transl_table=11
                     /translation="MRSSYRIPGITVQICGDAFPYLYWESESPMRSLSSSIWGGGVGEK
                     KYIVNRQVTKGYNCDEPLEEMAVFFEHEGINGTQAAGFLTAARVKDFGFASLVWPPEAL
                     ERGLEPELAVSAWATAGFSNKARAGLRVPEEVLFPGTINIVVIVDAQIGDAALAGAFIT
                     ATEAKTAALQDLGITVEGGLSATGTTTDAVLVAATGRGRYCTYTGTATRLGHLIGRAVY
                     EAVRQSGRKYQERTC"
     tRNA            6688..6774
                     /anticodon=(pos:3415304..3415306,aa:Leu,seq:cag)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="B7C51_RS18285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="B7C51_18280"
                     /product="tRNA-Leu"
     gene            6688..6774
                     /locus_tag="B7C51_RS18285"
                     /old_locus_tag="B7C51_18280"
     gene            complement(6930..7082)
                     /locus_tag="B7C51_RS29225"
     CDS             complement(6930..7082)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025001.4"
                     /locus_tag="B7C51_RS29225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_309557424.1"
                     /transl_table=11
                     /translation="MDFDPQGNLTLCFGIGQPDKLDISMFNIMNAIMRDELIPSPEGDS
                     RMARS"
     gene            complement(7102..7197)
                     /locus_tag="B7C51_RS29230"
     CDS             complement(7102..7197)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013793.4"
                     /locus_tag="B7C51_RS29230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ParA family protein"
                     /protein_id="WP_309555677.1"
                     /transl_table=11
                     /translation="MRNATTITIANQKGGTGKTTTAYNLNLCLIQ"
     misc_feature    complement(7635..7650)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 20.96"
                     /tool="antismash"
     gene            complement(7749..9044)
                     /locus_tag="B7C51_RS18300"
                     /old_locus_tag="B7C51_18295"
     CDS             complement(7749..9044)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025854.4"
                     /locus_tag="B7C51_RS18300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_18295"
                     /product="ATP-binding protein"
                     /protein_id="WP_083041041.1"
                     /transl_table=11
                     /translation="MHDGLFIGTTLLELVLLHCYFAVLFYAPDKSKRVIGINYAAAGSM
                     LFFSSVSFFPPLVTGLLSIGSAFLVSLLYPARMKTRLVFSVLYLLLGFIAELLSFYFIS
                     LFQNLKGEMNLTTLETRLLLLLVSSCLMLLFILILRFIKWKKYDYKLRLVYYFIITLML
                     LFSLLILNTLFFYAQRNWFNLLSIVGVLCINMLTFFLFDRMTEKYRLADENYQLQKQMD
                     YQDNSYEKTAHSFKSIKRIIHDTKKQLVFIRACIQEQRLQEAIVHINQTLEHMNAAYLR
                     ITTGNLVIDALVSHALNIANDNGIALKHDIRITASDIRLDRYDLCMVIGNVLDNAIEAV
                     RLVPNKEDKFIHLRMSSNSHSLFIHVVNSRLEQNQPNQRTLKDNPDFHGFGLTNIQRVA
                     EKYGGYLQTKARNRQFETSIMLPLSDEISPTI"
     gene            complement(9051..9779)
                     /locus_tag="B7C51_RS18305"
                     /old_locus_tag="B7C51_18300"
     CDS             complement(9051..9779)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012301.4"
                     /locus_tag="B7C51_RS18305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_18300"
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_237089173.1"
                     /transl_table=11
                     /translation="MAVCDDEEEIHQQLQQFFSQFSENESYTFEVNYFYSGEALLQYYK
                     EYGRYTFHFLILDVEMKGMNGIETALKIRSLPDKDVQIIFLTSYPQYMIDSFNVQPFQY
                     LIKPVSYERFETQIAKLCDYIHSVIQRYVVVKTNTEQIVLRASDIIAIEKVDKKHLELI
                     TMEQRFAAVSTLAEFSIKLDASFYQIYRSIIINLEHVHKFTATTVVMSNKDKFPLARSK
                     GKGIKEAYARYRIAQFNERG"
     misc_feature    complement(9878..9895)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: strong, score: 21.47"
                     /tool="antismash"
     gene            10001..10561
                     /locus_tag="B7C51_RS18310"
                     /old_locus_tag="B7C51_18305"
     CDS             10001..10561
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009372 - quorum sensing [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016526.4"
                     /locus_tag="B7C51_RS18310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_18305"
                     /product="accessory gene regulator B family protein"
                     /protein_id="WP_023485252.1"
                     /sec_met_domain="AgrB (E-value: 4e-20, bitscore: 70.1,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMANIVNKITLKIFQQGVVDEENLPIIRYGLQAIIEVSIIVATML
                     TISISFGRIIEAAAWMGTIILCRSFGGGYHAKTFKSCYFISVGAFILTLVVVDIMPCRL
                     FMPVTIACFMISIILFIHSYITAKQIRGLGIIDHLFYKVSMSIYICYYFFIIFMISLEI
                     INSVVVASLFGFIISQLSIESNS"
     misc_feature    10015..10030
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     gene            10631..10771
                     /locus_tag="B7C51_RS18315"
                     /old_locus_tag="B7C51_18310"
     CDS             10631..10771
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04223.1"
                     /locus_tag="B7C51_RS18315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_18310"
                     /product="cyclic lactone autoinducer peptide"
                     /protein_id="WP_077997075.1"
                     /sec_met_domain="TIGR04223 (E-value: 3.2e-14, bitscore:
                     50.8, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLTKLPWKALSMMAGLFAFIGANTRCWWIAHQPEVPEELHKLRK
                     F"
     gene            10796..10993
                     /locus_tag="B7C51_RS18320"
                     /old_locus_tag="B7C51_18315"
     CDS             10796..10993
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS18320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B7C51_18315"
                     /product="hypothetical protein"
                     /protein_id="WP_024095010.1"
                     /transl_table=11
                     /translation="MEKILVGEEQETAACWGCAVCASCLWCASCLACVVPVLGQAAVAA
                     AAAEVGAPATASAVAIGVSA"
     gene            11113..12534
                     /locus_tag="B7C51_RS18325"
                     /old_locus_tag="B7C51_18320"
     CDS             11113..12534
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015983.4"
                     /locus_tag="B7C51_RS18325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_18320"
                     /product="radical SAM protein"
                     /protein_id="WP_198041757.1"
                     /sec_met_domain="PTHR43273 (E-value: 3.7e-43, bitscore:
                     146.1, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 3.3e-11, bitscore: 42.0,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 3.1e-10, bitscore: 38.7,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGIHFTSKRGTEYYYDDLTGQIFPAKQTELSMLAEKFRNLAPDR
                     KLLDFHNIRNAGEEELKDYLCKGANGFKQLLLEITSFCNLRCKYCIYSDHYEFTKTYEN
                     KHMDFSVAKAAIDYYFSNFRNIQYRNPTRNPVIGFYGGEPLLNLQLIRQIVEYIKMTDG
                     EYDGIQYNITTNGISFTEDVQDFLTENNFSIIVSLDGYKENHDRNRVKADGTGSFDEVM
                     KNLKTFRERHKGYSKLAISSCYDIKTDMFQLRDFFDSEDLFLARLASVDANNTTYYDQF
                     TPHEKQKFIESLASLKEIFLNLTESNKIRKDSFLYSLIGMNYSELAFHPMMNEKRPDLL
                     PFTASCIPGEKIYVTIDGNYHMCEKINTHHAIGNIEQGIDYGKIACIINNFKKSVCQNC
                     TDCNVTRFCNICFQQCATDHNFEKKDSMCANIEAHVKAILADFIDVLETNPTLFEEITI
                     DYYKSIYEKVGVILE"
     gene            12527..12838
                     /locus_tag="B7C51_RS18330"
                     /old_locus_tag="B7C51_18325"
     CDS             12527..12838
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS18330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B7C51_18325"
                     /product="hypothetical protein"
                     /protein_id="WP_083041044.1"
                     /transl_table=11
                     /translation="MSNCYFRLFPECFLVVGRKKSVVCHLLDENMIWLDEVNTQKLKDA
                     EANHPVNAEDPFFSELESTNFGFFSDQTVFIDKLRPINSFSQKKLWQDAPELIWLYCM"
     gene            12820..13623
                     /locus_tag="B7C51_RS18335"
                     /old_locus_tag="B7C51_18330"
     CDS             12820..13623
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015983.4"
                     /locus_tag="B7C51_RS18335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_18330"
                     /product="radical SAM protein"
                     /protein_id="WP_077997078.1"
                     /sec_met_domain="Fer4_12 (E-value: 7.3e-06, bitscore: 24.5,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 3.8e-12, bitscore: 45.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 4.3e-10, bitscore: 37.6,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVLHVTNDCNLDCTFCKNSFCPVCKRFEERDEAELTVEQWKRIL
                     TELSHFGTSAVLFTGGEPTRYPYIHELIDFSIELGMATNLHTNGLVPLKQVPSVLGFHI
                     TVTSKRNLNKIIQNYCNIKDRVTLLVDDHLFSDVKQITGNQWKIMRTTHKKPSIVKERL
                     VKTNMNSFYARKLFDPCLNGKIAVSYVGDVYPCLGSQAPLLNLKRDSVSQAVKLLVRDF
                     WRQNVDSRDHGLKCRECEFKYSCSACRFLDTEENCAYSLEESEWL"
     gene            13614..14549
                     /locus_tag="B7C51_RS18340"
                     /old_locus_tag="B7C51_18335"
     CDS             13614..14549
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF024793.4"
                     /locus_tag="B7C51_RS18340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_18335"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_083041046.1"
                     /transl_table=11
                     /translation="MVIKICSVSKNLGHRSILSNVSLEIDKGQIFALVGPNGAGKTTLV
                     RLIMNLYEATSGEIYVNGINVTDRRFNQEKKKIGFLFDHIGLFKDLNAWENIEFFDRIY
                     HPHSKKEERRNRIEKLLQDFDLYERKDSKITFFSRGMRQRLVLARALINDPNIIILDEP
                     SRGLDLEGQITLRNFLLNCKNNGSTVLINSHDLSELQKVCTHIAFIKEGRIIRSGTYDE
                     IREAHAHHNYLLKGKDIADQLGRVNPESGISWIFKNEREAVVTVSHSGIDILDWLSSNR
                     IRYEEFKKASDDLEELYQEIINKTQDPETI"
     gene            14653..15180
                     /locus_tag="B7C51_RS18345"
                     /old_locus_tag="B7C51_18340"
     CDS             14653..15180
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS18345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B7C51_18340"
                     /product="hypothetical protein"
                     /protein_id="WP_083041047.1"
                     /transl_table=11
                     /translation="MEDFTTFTYFLYIPFLFSVVTQNDIYFYDLTTSIETLLATPLDAA
                     QILKEKGLFIVIKSVILGVAMFPVYLIILYVNGYKPNILLWNEALLLLLCFLLQYSLSL
                     LVGTVTWLYGKKSRLGIIIGQGLLLNGLTAISSWDIKGSGTVMVISIVAAYGVSRVLIK
                     RLRTENMIMRCL"
     gene            15305..15877
                     /locus_tag="B7C51_RS18350"
                     /old_locus_tag="B7C51_18345"
     CDS             15305..15877
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS18350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B7C51_18345"
                     /product="hypothetical protein"
                     /protein_id="WP_158530431.1"
                     /transl_table=11
                     /translation="MTILVFFPATFTLFSSVIHFSMEDIIGSESILATSISIQKIWLWN
                     LIFIVASGYVYSIILLTAGTGLLNLVKGIGYFSLSVYDEMQFIANLALCFAFLGAATCH
                     YADYSFGKQMTASVFALIHLACPFVFLIWGSRLEVNQNSVWITLATAVFIFLIAFIFIR
                     NSNKEKLLMNTQKLMMAYNNTNNTIEE"
     gene            16092..16838
                     /locus_tag="B7C51_RS18355"
                     /old_locus_tag="B7C51_18350"
     CDS             16092..16838
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S41"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015531.4"
                     /locus_tag="B7C51_RS18355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_18350"
                     /product="S41 family peptidase"
                     /protein_id="WP_083041049.1"
                     /sec_met_domain="Peptidase_S41 (E-value: 2.6e-23, bitscore:
                     80.6, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSIWQKLSRKRRNTSSIEHDIKFGDYMYIAIGFFDHGVSRKMEE
                     VLKRYRDRKGLILDLRNNTGGSIEECMKISRLLLPSCDIAELRYPGKTIIYTSDEARFG
                     FQRIFILVNGYTASCGEILALTLRAHLNEAAVIGNRTAGKDIGQRTFNHRKKRILFSVS
                     SFYWTVEGETAISLRNIWKRTTRPVYPSYQTMIITDISILSTLSLQVVRGRNMPENGKP
                     ACYFIAVQSRLLNGNAVPGIKKTCCR"
     misc_feature    complement(17436..17451)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     regulatory      17504..17681
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            17832..18464
                     /locus_tag="B7C51_RS18365"
                     /old_locus_tag="B7C51_18360"
     CDS             17832..18464
                     /EC_number="5.4.99.60"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003724727.1"
                     /locus_tag="B7C51_RS18365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_18360"
                     /product="cobalt-precorrin-8 methylmutase"
                     /protein_id="WP_083041051.1"
                     /transl_table=11
                     /translation="MSYIKDPKLIEEKSFEIIQEIITQTRPEYAFRNREEELVMKRAIH
                     TTADFDYLDNLVFTHDALAKIRETIRHGGMIFTDTNMALSGMNKRILDQYGCRYRCYVN
                     EPETAEIAKQQGITRSMAGIQLAAREEERKLFVIGNAPTAVYKILEMEDAGKLDAEAVV
                     GVPVGFVGAAESKEALYESDIPAVVARGRKGGSNLAAAIINAVLYAM"
     gene            18479..19600
                     /gene="cbiD"
                     /locus_tag="B7C51_RS18370"
                     /old_locus_tag="B7C51_18365"
     CDS             18479..19600
                     /EC_number="2.1.1.195"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cbiD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003724728.1"
                     /locus_tag="B7C51_RS18370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_18365"
                     /product="cobalt-precorrin-5B (C(1))-methyltransferase
                     CbiD"
                     /protein_id="WP_077997086.1"
                     /transl_table=11
                     /translation="MGDYVYHEGKKLRKGYTTGTCAAAAAKAAAAMVIKQEKIAGVSVI
                     TANGTSLQIPVKKQEFDQHTATAAVQKDGGDDVDATHGMWIFAKVTLNAGGEIRLDGGQ
                     GIGRVTQKGIAVPVGEAAINPIPRKMIIAAVREEIGAKLGADIIIFAPEGEERAERTMN
                     SRLGIIGGISILGTTGIVTPMSDEGWKRSLSMELEMKKAQAFRKVILVPGNYGERFVEE
                     HLGIDGKYVVSMSNFVGYMLKEAQRLAFKHVLLVGHFGKLIKVSAGIFTTYSKDADARA
                     EILVANLALASAPVPLLERIAACTTTEAAGEIMVAEGYSEVFQTITDKVKKRAEDFLKF
                     SKPFVDIDVITFSTERGMLASTCDISAIREAWR"
     gene            19597..20202
                     /locus_tag="B7C51_RS18375"
                     /old_locus_tag="B7C51_18370"
     CDS             19597..20202
                     /EC_number="2.1.1.289"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TP_methylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012581515.1"
                     /locus_tag="B7C51_RS18375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_18370"
                     /product="cobalt-precorrin-7 (C(5))-methyltransferase"
                     /protein_id="WP_077997087.1"
                     /sec_met_domain="TP_methylase (E-value: 2e-30, bitscore:
                     104.5, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHIVGIGPGKPELMTSAGIILIQNADVIIGSKRQLNEIPHDIPA
                     ERKLLPSNLSELETFLLGKTGQDIVLLASGDPLMYGIGNWALKKFPKEQLQIVPGISSI
                     QYLCTRCGIAMNDLYMTSSHGKQPDFEFLLAHPKVAMVTDSKIGPAEIAKEILQRKLNK
                     KLIIGENLSYPDERLHLLKPEQVADHYEMNVVVILDEG"
     gene            20192..20767
                     /locus_tag="B7C51_RS18380"
                     /old_locus_tag="B7C51_18375"
     CDS             20192..20767
                     /GO_function="GO:0008276 - protein methyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006675840.1"
                     /locus_tag="B7C51_RS18380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_18375"
                     /product="decarboxylating cobalt-precorrin-6B
                     (C(15))-methyltransferase"
                     /protein_id="WP_083041052.1"
                     /sec_met_domain="PCMT (E-value: 2.9e-07, bitscore: 28.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDEVFIRGKTPMTKAEVRAVSIDKLSIDGNSRRFLDVGAGTGSV
                     ALQVARMFPHVSVTAIERSGEALALIEQNRQQLLLENVDIISAEAPIPLENTVFDAIFI
                     GGSGGKLAEIIDWSHTLLKPGGQLVLNFILAENVLEAAACLEKGPWHEVEVIQLQVSKW
                     HELGKGHYFKPQNPTFIIACQKERSGTA"
ORIGIN
        1 agtccgtaag cattggagag gaaagtagta aaaatttcag cgtaaataat aaacaaaaac
       61 agcatctgcc atataccgcc tacatgatcc agaatgcttc ccatgggaat gtcaaattgg
      121 gatatatccg gcatttgtgc tgacatcgca taatgggctc ccataatcaa tacgccaatc
      181 atacaacccc ctagaattcc gcctcttatc agaacttttc tgtcctgaac ctgggcccca
      241 gcgggacgag aacagcttgt gctgtagcta agttaaaact tgtatacagg aagggggata
      301 gccaggaata taccggagaa aaatccgttg taatgcgcag ccagttaccg gaacctggtg
      361 ttccccaagt agtagctaca acaagaaggc tgaataagat catgcaggga actacaatcg
      421 tattgacagt cataatcccc ggattccttt cgtcaggata aaataggtga gcattataat
      481 aatcaaagcc cccactttag aatcaattcc aagctgttct tcaaacacag cccccctccc
      541 gccagcatca cgatactcac tccaagaaga accaataagg agaatagggc cacccacttg
      601 cctgccttgg ccccaaataa ataacggatc atgtcttcat aagatttagc cctgacttcc
      661 cgggacaata acatcaattt tatcccgaca cctatgaaca ggattgtgga aagcaaaata
      721 gtgcccgttg caacagcccc ataccgggtg aaaaattgca gaatttcctg cccggaggca
      781 aagcccgctc caacaaccgt acccacgtag gtgaaggcaa tttgaagtac ttgtatatgg
      841 cgtttcaact tatcttgtct cccttccctt ttatagtaca aggtatgtaa ggaaagggac
      901 gggcatgaca ggctaaaaag acgaataaga aggaaatatg ttgatcaaca tggaagtaat
      961 taaggatgat aacgtattgg gagtggctga acttgaagga aacggttttt tctttacttg
     1021 cggattatgg ttattacgcc ttgtacagcc ttctggcgtt aggaattatc ggacttccta
     1081 tcccggatga aactttgatg gcgtttgttg ggtcgatgac tatgcacggg ggtcccatga
     1141 atttttgggc ttctttggca gtggcttatg ccggaacgat gacaggtatg acaatcagct
     1201 atacggttgg aagaaaagta ggcaagccct ttttgtataa atatgggaaa tggatgaagc
     1261 tgacaccggc caggctacaa aaagcggaga attggttccg taagtacggc ctttggacag
     1321 taggcttcgg ctattttgtt ccgggggtaa ggcattttac ttgttatctg gctggaatga
     1381 gcggagtgaa atggtggaaa tatttgcttt atgcgggcag cggggctttg gtatggtgtg
     1441 ttactttcct gctattgggc agatggatcg gcagaaactt tgatcgcgtt cttcatatgt
     1501 ttcaccgtta tactggagtt accttaggaa ttttaggagg tctgctgata ctggggctta
     1561 tcgtatatct ggtattcaaa cgaaaaaaaa aacagcgtaa tcacatgtga gccagcgtca
     1621 aactatatgg caaacaaaac aagcaagccc acccggataa ttgaagtgcc ccctgtcaag
     1681 tagacagtgt aaaaaaacaa aaacagttag tttgtttccc tcagttctgt taaattgaac
     1741 tgagggtttt attttcttct ctcattttta tgcagcttgt tttcgatatt cgctgggaga
     1801 caggccactt aaacgctctg tatagcggta attgttgtag tagtggatat aatttctcac
     1861 gtctttgaga acgtcttcat aggtgtcgtg tttccttaga taaaagcttt ctgccttaaa
     1921 tgtaccccaa aatcgttcaa tgggttgatt atctagacat cggctcaccc gagacatact
     1981 tttagtaaaa ccgtacttaa gctgaagtag actgtattca tgtgaagtat actggaagcc
     2041 tctgtcgcta tgcagaagtg gagtcacacc cgggttcctc cagtaggcct tattcaccgt
     2101 atccatgacg agttttttgt tgttggaggg gcttaacacc catgaaacga tggagttatc
     2161 gtatacatca acgatagcac tcagataggc tttacgacca ttcccatact tcaattctgt
     2221 gacatctgtg caccacttta aattgggaga gtccgcgtga aactcgcggt tcatcacatt
     2281 ttcagccaca tgtattgcag aggatttcac gtaattcggt cgtttcctgc gaatcaccgc
     2341 ttttaattca agagcgcgca tgattcgata ataacgtttt ttgttgtaac tctttttgag
     2401 tttccggttc aattgtgtgc ggatttgacg ataaccaagt acaccctttc tcttgtcata
     2461 gcgaagtttc acttccttgg ccaatgaaag gatttcaagt tccctgatgg atggtttcca
     2521 ttttagccat ttataatagg cagatcgagc gactccggct agcttgcaca gcttcgtgac
     2581 ggcatagcct ttctcagcgt gcagttcttg gatagcttga taccagtctg catgtcggac
     2641 taacgttagc gtgtatgtcg tcgccggatc tctgccaact tttttgccag agcgttctcc
     2701 atttctaaat actcgttccg tgcttctaat tctttgatcc gaagcttgag tcgttcatga
     2761 tcatccaact cttccgcagg cttgttacga ccgcgattgt ccttgagggc ttcctcaccg
     2821 ccagatttat atttacgaac ccatgcgtac acctgtgaat aagaaacatc atatttctct
     2881 atggatttct gataatccag atcatttgcg atcgtatact gtgcaatttc aatgcgttct
     2941 tcgaaagtgg ttttacgtcc tttgttcata cgagatagtc caattccttt acgagtagat
     3001 tttatttcta ccccattagt atacttggag atccatctcg tcaaaacatt ttactagaaa
     3061 tatgatactt ctttgtcgcc tctcgtatag aatgactacc ggataataca tctctgattg
     3121 cagccagctg cagatcctct gagtaagctt tacatcctct ggattccttt aatccgtcaa
     3181 gaccatctgc tttatacttc cttacccaat ctgttaccgt gtttttgtct attcccagct
     3241 gtttcgcctc ataatttggg tttgtctcat tctgaagaca tcgctttacg acacgtagct
     3301 ttacctctaa agaagttgga ctccttttgg acattgtaaa aactcccatc attgtagagt
     3361 agatgttttt gttttttcta ctgtctacta tgaggggagc atatcaaatt gttgtggctt
     3421 gcttattatt ctttaaacag ttttatggac aagacctggt cgagctttgg gtccacatcc
     3481 agccgaagaa tggttccgcc gctttcataa gctaatacgt aagaggtctt ggtcgaagga
     3541 agccccagtg tattgaccgc atctttcgta gaagagccta ttttaacacc gtgcaatccg
     3601 ggattaattt tatcgttctt gatctctaca aacttcagtt tgcggtttcc gttaaatcct
     3661 accgaaaaat ccgcgtattc ataaactgtt acaggatttc tggtttcctc cattttaaaa
     3721 aagcttttgg ctttacccag tttatccata acttccagta tgtccatgcc aggctgtaaa
     3781 ccaagtaaag caggttttgc cggagtgaat tgatcctgct catttacatg gagcggcgga
     3841 ttatcagctt tcggatctac aaaaggctcg ttatttgact gactggagat gaaggtcctg
     3901 gaagttgact gcctggaagc ggaggatgag gaatcactgt attcgggctg tacggtttgt
     3961 tcctgggtag ataccggttt ggccgactcc ccggtattcc cgcatccggc caagatagtg
     4021 ataacaattg aggtaagaat agcaagtgta aaacgagact ggtgtatcat aatatccgtc
     4081 cctttctttt tcctaactaa ggataagcct ggcgaataat gtcggattca ccgctttaat
     4141 attatagacg tttttaaacc ggaaaaccct tcgacaaaat tgacatttct atatataaag
     4201 acccttaaag caaatgaaaa gttttatttt acttccataa attcagattt atctatacct
     4261 tgtaccaggt tgaatggtat ctaagttttg aaatggattc aattcattta ttttataaaa
     4321 tcgagctcct ttttggaaga agtttctagg ccgtcttttc ggccccgcag ttttccgata
     4381 taataaaaga aggcaaacgg aaaggaggaa tcagcatggg gaacgagacg cttccgaacg
     4441 attacttgat tgaaaagcta tccgaagcga agacgctttt tgagcggtcc cttgactgta
     4501 aacacactga gttcgatgac ctgtacccat acatgattga gcatcctcaa ttcttttggt
     4561 ataaacgcta tgtagcgtgg tccgaactgt tgactgtcgt taagatttgc tcagaacttt
     4621 ccgttccgtg gaagcagact tttacaagtc agcaggttca gtatattgag aaccgtgtca
     4681 tgtccagcaa ggttctggat gaatggttcg aaaggaacga ttccaaggaa catgtcgggt
     4741 aataaggaaa aattttttta taagatcaac actttccggt gaaaataaac tttgaaagac
     4801 ctgtgccttc ttcgtgacga attgggctgc aggtcttttt ctgaaggtaa aaaaagaagt
     4861 ttggttattc aaagtatatt catatgctca atagtttctt tcgtctcttt cgttccaagc
     4921 cggtgtacaa gttcgtaaat gtttttaagt cctctatcgt acctgtcatt ttcttcatcc
     4981 gaatggtatt ctttgaaagg gattaaagcg cggaaatggg tacttatgtc agccgaataa
     5041 agctcctcga ataatacttg aagctggtcc agctcttccg gactggcgta aatttcaaaa
     5101 tcgtagttgg tatcttcttt attctccaca atgtcgccgg aggccacagt aaggtaatat
     5161 ttttttttgt caaccaattt gtccgctcct ttccttattg gccagttaca gctgatctga
     5221 ttaaagttat ccttagtctt tccttcagcg gatgaccgta tgtggtttga ttggaaattt
     5281 aagctgaaat ttgagagaat ttacccttta ggctatgata gcttggtaaa gacagatagc
     5341 tgataatcgt attcttggta aatgactttg taaaacaggc ctataaaaag gttacatgga
     5401 aaatacatgg gatctaacca cccgtcgtgc agcatcgcaa cgcgtgcccg ggaagcggcg
     5461 ctttgggtag aagttattag ttcagggact ctgtgaaatc aaccataaat cctctacaat
     5521 ggaaaagagg ttttccccaa atgtttataa taggagggta tgacagcaga tgatttcgga
     5581 tgaacaactg gatgattaca ggatcaaggg aaaaaagctg cgtgtcattc gagatgcgga
     5641 cccggccaat gatgtgaagg gcattgttgt ggcatgggat gaacaacatg ttctgatccg
     5701 gaaacaaaac aggaatattg tcaagttgtc ccgcagctat acttaccagc ctttcgaagc
     5761 ggaaagaccg ggtgaattta cactcccgga caaaggcgaa taaatttgct gaagaacaca
     5821 tctatagaaa gttgctgaag aagagattta tagacagcgg agagaggata caggatgcgg
     5881 tcatcttacc ggattccggg aataactgtg caaatttgcg gggacgcctt tccttatttg
     5941 tattgggaaa gtgaaagccc gatgcgttcc ctcagttcgt ccatctgggg cgggggagtt
     6001 ggagaaaaga aatatattgt aaacaggcag gtcacaaagg ggtataactg tgatgaacct
     6061 cttgaagaga tggccgtctt ttttgaacat gaaggcataa acggtaccca ggccgccggc
     6121 ttcttaacgg ctgcccgggt caaggatttc gggtttgctt ctttagtctg gcctccggaa
     6181 gccctggaac gcggactgga accggaatta gctgtctcag cctgggcaac ggccgggttc
     6241 agcaataagg caagagcggg cttaagggtc cctgaagagg tcctttttcc cggtacgatc
     6301 aatattgttg tgattgttga cgcacagata ggggacgcgg cattggccgg tgccttcatt
     6361 acggcgacag aagcgaagac agccgccctt caggatttgg gtataaccgt tgagggaggg
     6421 ttatccgcta ccggcacaac tacggatgca gttcttgttg cagcaacagg aaggggccga
     6481 tattgtacct atacgggaac ggctacccgg ctaggtcatt taatcggacg ggccgtttat
     6541 gaagcagtcc ggcaatctgg ccggaagtac caagaaagga catgctgagg gttatccggc
     6601 atgtccgttt ctattcatga attcgctgaa tttttcccgg ttgacatcct cgatggtgca
     6661 tgttatatta ggtatcgttc ttgttaagcg gtcgtggcgg aattggcaga cgcgcacggt
     6721 tcaggtccgt gtgggctaac ccccgtggag gttcgagtcc tctcgaccgc accacttcat
     6781 caatgacagg tttctgatct gctttttctg gcagagcagg aaccttttta ttattcaata
     6841 tcttttagct ggcactcatt acctgggcag aagaaatctt ggaactgtac tccaaatgag
     6901 cgtaaatatt agctgtagtg gagaaatgtc taagaccgag ccattcttga atctccttca
     6961 ggggagggga taagctcatc tctcatgatt gcattcatga tattgaacat gctgatgtcc
     7021 aacttgtcgg gctgcccgat gccgaaacat aaggtcagat taccttgtgg gtcgaaatcc
     7081 accaagagaa cctttttttc ttcattggat aaggcataag tttaagttgt aggcggtggt
     7141 cgtttttccg gttccacctt tttgattagc aatggttata gtcgtagcgt ttctcatgtt
     7201 agccctcccc aaagctgtcg cttcgtttat ttgtcaatgg tagggagtgg gctggtttgg
     7261 tcgttgttct ctccgagttc tctcaaacat ccaaaatcgg ccgcattttc tggaatcgtc
     7321 gggaagcctt gcggcgcttg aatttgaaca aaaaaaccgc caaaaacctt gatttatcaa
     7381 ggcttttgac gggttttaaa ttcctcatcc ttgacttaga ttccgcttat gttacaatga
     7441 cgtagaagtt tcaggtccgt gtgggctaac ccccgtggag gttcgagtcc tcccgaccgc
     7501 atatacttac atatcaatag ggcctttaca tgatgaataa gtcatgtaaa gacccttttt
     7561 tttgttcggg atttgcaatg tattgctcat cacttgagcc gaagaaatct tcgaactatc
     7621 cagatgagca taaatgttgg ctattagagt aatggctatt ccaaccaggg accaagtatg
     7681 tcattgcaaa taccatcggg gaaaggtggg cataaatatt actgtaaaaa ccagttgtct
     7741 tttttatatc atattgtcgg gcttatttca tctgataaag gaagcatgat gctggtctcg
     7801 aattgtctat ttctggcttt tgtttggaga tagccgccat atttttccgc tacccgttga
     7861 atattggtta acccgaatcc gtgaaagtcg ggattgtctt tgagagtgcg ctgattcggc
     7921 tggttttgtt ccagccgcga attcaccaca tgaataaaca aagagtggga attagaggac
     7981 atgcgcaaat ggataaactt gtcttccttg ttgggaacga ggcgaacggc ttcaatggca
     8041 ttgtccaaca cattacctat gaccatgcat aaatcataac gatccaggcg gatatctgaa
     8101 gcggtaatgc ggatgtcgtg tttcaaggca attccgttgt catttgcgat attaagcgca
     8161 tggctgacta gagcgtcaat cacaaggttt cccgtagtaa tgcgcaaata agcggcattc
     8221 atgtgctcca gcgtttgatt gatatgtacg attgcttcct gtaggcgctg ctcctgaatg
     8281 caggcgcgaa tgaacaccaa ttgttttttc gtatcatgga tgattcgttt gatactttta
     8341 aaagaatgtg ccgttttctc atagctgtta tcctgataat ccatctgctt ttgtaattgg
     8401 taattttcat cagccagccg atatttttca gtcattctat caaacagaaa aaaggtgagc
     8461 atgttgatac agagaacgcc tacgatagac aaaaggttaa accaatttct ctgcgcatag
     8521 aaaaacaggg tgtttaaaat tagaaggcta aacaaaagca tcaacgtgat gataaaataa
     8581 tagaccaatc ttaacttgta atcgtacttc ttccatttga taaagcgaag gatgagaatg
     8641 aaaagaagca taaggcagga agagacaagc agaagcaata gccgggtctc caacgtggtc
     8701 aaattcattt cacctttcaa attctggaac agagatatga aatagaatga cagcagttcc
     8761 gcgatgaaac caaggaggag gtacaacacg gaaaaaacca gccgggtttt catccgggcc
     8821 ggatacagaa gggagacaag aaaggcgctc ccaatggata acaatccggt gacaagggga
     8881 ggaaagaatg aaacggagga gaaaaacagc atgctcccgg ctgctgcata gttaattcca
     8941 atgacccgct tacttttatc gggagcgtaa aacaggacag caaagtaaca gtgaagcaaa
     9001 actaactcca gcagagttgt tccaatgaat aatccatcat gcatgggaag ttatcctctt
     9061 tcgttaaatt gggcaatcct gtaccgtgca tacgcctctt tgatcccttt ccctttagaa
     9121 cgcgcaagcg gaaatttgtc tttattggac atgacgacag ttgtggctgt aaacttatgg
     9181 acatgttcca ggttaatgat gatagaacga taaatctgat aaaatgaagc atccagcttg
     9241 attgaaaatt cggctaatgt ggaaacggca gcaaagcgtt gttccattgt aataagttcc
     9301 aaatgttttt tgtccacttt ttcaatagca ataatatcgg aagctcttag gacaatttgt
     9361 tccgtgttcg tcttaacaac aacataacgt tggatcacgg aatgaatata atcgcataac
     9421 tttgcgattt gagtttcaaa ccgttcatag gaaacgggtt tgatcagata ctgaaagggc
     9481 tgcacattaa agctgtcgat catgtattgc gggtaactgg tcaaaaaaat aatctgtaca
     9541 tccttatcgg gtagggaacg gatttttagg gcggtttcga ttccgttcat gcctttcatt
     9601 tccacatcca ggatgagaaa atggaaggta tatcgaccgt attctttata gtactgaagc
     9661 aatgcctctc ctgaataaaa gtagttaacc tcaaaagtat aggattcgtt ttccgagaac
     9721 tgcgaaaaaa actgctgcaa ttgctgatga atttcttctt catcatcaca gactgccact
     9781 cgaagcaaag atgaccacct ctctctacta aagtacttcc attctacttc gatttttcct
     9841 tctagcgcta actcattctt cctaaatcta ttcatattta acataaatat aacataaatc
     9901 tgacaaagac atgcagttta tcccctgtta tctgcaatta aggtccaata tatttcaata
     9961 aataacataa tatgctatat tggtttgcgg gtgatggaac atgatggcaa acattgtgaa
    10021 taaaatcacg ttaaaaatct ttcaacaagg tgttgtggac gaagagaatt tgccgattat
    10081 tcgctatgga ttgcaagcga taattgaagt ttcgattata gtggcaacta tgctgacgat
    10141 ttctatatca ttcggtcgga taattgaagc cgcagcttgg atggggacca ttatcttatg
    10201 cagaagtttt ggaggaggct atcacgccaa gacctttaaa agctgttatt tcatatctgt
    10261 cggcgctttt atactgactt tggtagtggt ggatataatg ccctgccggt tgttcatgcc
    10321 tgtgactatt gcttgtttca tgatttctat tattctcttt attcattcgt acattactgc
    10381 caaacaaatc agggggcttg ggataattga tcatcttttt tacaaagtga gcatgagcat
    10441 atatatttgc tattactttt tcatcatttt catgatttca ctggaaataa tcaattcggt
    10501 agtcgttgca agtttatttg gatttattat ttctcaatta tcgattgaat caaattcata
    10561 aaacaactcg gatggaaatc taagttatga aattgattcg attttcatct aacataaggg
    10621 ggcaggaaca atgaagctta ctaaattacc ttggaaagcg ctaagcatga tggcaggact
    10681 ttttgctttc attggagcaa atacaaggtg ttggtggatt gcccatcaac ccgaggttcc
    10741 cgaagagctg cataaattac gcaaattcta attccaatga aaggaggtga acaaaatgga
    10801 aaagattctt gttggtgaag aacaagagac tgctgcatgt tggggctgtg cagtctgcgc
    10861 ttcgtgtcta tggtgcgctt catgtcttgc ttgtgtcgtt ccggttctgg gacaagcggc
    10921 ggtagccgca gctgctgctg aggtaggagc gccagcgaca gcttcggccg ttgcaatcgg
    10981 agtttctgct tgatccaatg actactgctc ctgcgtttca tctgtggaca gattgcagga
    11041 tttcttcata aagctaaaac gatatgggtg cagacgcagg agtccattaa ttcataaatg
    11101 aagaggtgtc ctatgaaagg gattcacttt acaagcaaac ggggaaccga atattactac
    11161 gatgacctga cgggtcagat atttcccgca aaacaaaccg aactttccat gctggccgaa
    11221 aaattccgga atttggctcc ggaccggaag cttttagatt ttcataatat tagaaatgcc
    11281 ggagaagagg agctaaaaga ttatctttgc aaaggtgcca acgggttcaa acaattactt
    11341 ttggaaatta catctttttg caatttgaga tgcaaatatt gtatttattc cgatcattat
    11401 gaattcacta agacttacga aaataaacat atggattttt cggttgccaa ggccgccata
    11461 gattactatt tttcgaattt ccggaatatt cagtatcgca atcctacaag aaatcctgtg
    11521 atcgggtttt atggaggaga acctttattg aatctccagc ttatccggca aatagtggag
    11581 tatatcaaga tgacagacgg agaatatgat ggcatacagt acaatataac aaccaatggt
    11641 atcagcttta cggaggacgt tcaggatttt ctgacggaga ataacttttc cattatcgta
    11701 agtctggatg gatataaaga aaatcatgac cgtaataggg tgaaagctga cggaaccgga
    11761 agctttgatg aagttatgaa gaatctgaag acgttcagag agaggcataa aggttattcc
    11821 aagctcgcca taagctcctg ttacgacatt aaaacggata tgtttcagct gagggatttt
    11881 tttgacagtg aagatttatt cttggccaga ttagcttctg tcgacgctaa caatacaact
    11941 tattatgacc aatttacgcc tcatgaaaag cagaaattca tcgaatctct cgcctcgtta
    12001 aaagagatct ttctaaatct gacggaaagc aacaagatac ggaaggattc attcctgtat
    12061 tctcttatcg gcatgaatta ttcggaattg gcatttcacc ccatgatgaa cgaaaaaaga
    12121 ccggatctgc ttccctttac tgcttcctgt attccaggag aaaaaattta tgtaactata
    12181 gacggcaact accatatgtg cgagaaaata aatactcatc atgccatagg aaatattgaa
    12241 caaggtatcg attatggaaa aattgcatgt attattaata atttcaaaaa gagtgtgtgc
    12301 cagaactgta ctgactgtaa tgtaacaaga ttttgcaata tctgcttcca gcaatgcgcc
    12361 acggatcaca atttcgagaa aaaggactcc atgtgcgcaa atattgaggc tcatgtaaaa
    12421 gcgatacttg cagattttat cgatgtactt gaaacaaatc ctacattgtt tgaggagatt
    12481 accattgatt attataaatc tatttatgaa aaggtagggg ttattcttga gtaattgcta
    12541 tttccgtcta tttccggaat gttttttagt agtgggcagg aaaaaatcag ttgtatgcca
    12601 tttacttgat gaaaatatga tttggctgga tgaggttaat acccaaaagc taaaggacgc
    12661 cgaggcgaat catccggtga atgctgaaga tccgttcttt agcgaactgg agtccacgaa
    12721 tttcggtttt ttttcggatc aaaccgtatt catagataag ttaaggccga ttaatagttt
    12781 cagccagaaa aaattatggc aggatgcccc cgaattaata tggctgtact gcatgtgact
    12841 aatgattgca atctggattg cactttttgc aaaaattcat tttgtccggt atgcaaacgg
    12901 tttgaggaga gggatgaagc agagttgacc gtagaacagt ggaaacgcat tctgaccgaa
    12961 ttgtctcatt ttggaacaag cgcggtgtta tttacaggag gggagccgac tcgttatccg
    13021 tatattcatg aactgatcga tttctcaatt gaactcggaa tggcaacaaa ccttcatacc
    13081 aatggcctcg ttcctttgaa gcaggtccct tccgtgcttg ggtttcatat caccgtgaca
    13141 agtaaacgga atcttaacaa gattattcaa aattactgca acattaaaga tcgcgtcact
    13201 ttactggtgg acgatcactt attcagtgac gtgaagcaaa taacgggaaa tcagtggaaa
    13261 atcatgagga cgacgcataa gaagccttcg atcgtgaaag aacggctggt caaaaccaat
    13321 atgaacagct tctatgccag aaaactattt gatccatgtt taaacggcaa gatagccgtt
    13381 tcatatgtcg gagacgtata tccgtgcttg ggaagccaag ctccgttact caatttaaag
    13441 agagattccg tttctcaagc ggttaaatta ctggtacggg atttttggag gcagaatgtg
    13501 gattcgaggg atcatgggtt aaagtgtcgg gaatgtgaat tcaagtattc ctgcagcgcc
    13561 tgcagatttc tggatacgga agagaattgc gcttacagct tggaggaatc ggaatggtta
    13621 taaagatatg cagcgtcagc aaaaatctgg gccatcggag tattctgagc aatgtcagcc
    13681 tggaaattga caaggggcag atttttgccc tggttggtcc gaacggggcc gggaagacaa
    13741 cgcttgtccg attaattatg aatctgtatg aagcgacgag cggggaaatt tacgtaaatg
    13801 gaattaacgt taccgacaga cgttttaatc aagagaagaa aaaaatcggc tttctctttg
    13861 atcatattgg tctcttcaaa gatttgaacg catgggaaaa catagaattt ttcgatagaa
    13921 tttaccatcc gcactccaag aaggaggagc gccgaaacag gatcgaaaag ttgctgcagg
    13981 atttcgactt atacgaaaga aaggatagca agattacctt cttctcccgt ggaatgaggc
    14041 aaagacttgt tttggccaga gcattgatta atgatccgaa catcatcatt ttggacgaac
    14101 cgtccagagg attggacttg gaaggtcaaa ttactcttcg aaatttttta ttgaattgca
    14161 aaaacaatgg ttcgacagtg cttattaact ctcacgattt gagcgagctg cagaaagtat
    14221 gcacacatat cgccttcatt aaagaaggga ggattatccg gtccggaaca tatgacgaaa
    14281 tacgggaggc ccatgcacat cacaactatt tgttaaaagg caaggatatt gccgatcagt
    14341 tgggaagagt aaacccggaa agcggcatca gttggatttt caaaaatgag cgggaggctg
    14401 ttgtgacagt cagccattcg ggaatagata ttctggattg gttgagcagc aaccgtatcc
    14461 ggtatgagga atttaaaaaa gcaagcgatg atttagaaga attatatcag gaaatcatca
    14521 ataaaaccca agacccggag acgatatgaa taagtcgggg ttgtatattg gagggaatta
    14581 aaacggcaga aacatctgtg tatagtaacg tcgttgcagt tcttgcttac gacattgtta
    14641 ctggtttgga gaatggagga ctttacaaca ttcacttatt ttttatatat tccctttctt
    14701 ttttccgttg ttacgcaaaa tgatatttat ttttacgatt taacgacatc tatagagact
    14761 ttactggcaa caccgcttga cgcagctcaa attcttaagg aaaaaggact atttattgtt
    14821 attaaatcgg tgattctggg agtggccatg tttccggtct atcttattat cttgtacgtt
    14881 aacggttaca aacccaatat tctcctatgg aatgaagctc tgctcctcct cctgtgcttt
    14941 ttattacaat actcgttaag tttacttgtc gggacagtga cttggctata cgggaaaaag
    15001 tccagactag gcattattat tggccagggg ctgcttttaa atggattaac cgcaatcagc
    15061 tcatgggata tcaagggtag cggaacggtt atggttatct ctatagttgc cgcgtatgga
    15121 gtttccaggg ttctgatcaa acggctgcga accgaaaata tgataatgag gtgtttataa
    15181 tcttatgaat gctcttttct ggaaatcgct tcaagcaatg aagcatcgga aaccacgatt
    15241 ggcggtcctt ttcattctcc ctatcattta tttgtatgcc ttataccggt ctgggctgag
    15301 ccaagtgacg atattggtct tttttccggc aacatttact ttattcagca gtgttattca
    15361 tttttcaatg gaagatatta ttggcagcga atccatcctg gcgacatcca tttccataca
    15421 aaaaatctgg ctgtggaatc tcatttttat tgttgcttca ggctatgttt attcaatcat
    15481 tttacttact gcggggacag gcttattgaa cttagttaaa ggaattgggt atttttccct
    15541 tagtgtgtat gacgaaatgc agtttatcgc taatcttgcg ctttgttttg cttttctcgg
    15601 agccgcaact tgccattacg ctgattatag ctttggaaaa cagatgaccg cttctgtatt
    15661 cgctttaatt catttagcat gtccctttgt ttttcttatc tggggctcga gattagaagt
    15721 aaaccagaat agtgtatgga ttaccttggc aactgcagtt tttatttttt tgattgcttt
    15781 tatttttatt aggaactcca acaaagaaaa gctccttatg aatacgcaaa aattaatgat
    15841 ggcatataac aacactaaca atactataga agagtaaagg ggctgagtag aagaatgcta
    15901 ttcttctctt taccgttata tatcagcaaa agagcagcca aacagtattt ggaactgtat
    15961 gaggaaaacg aactgcaatt agaccggaac gaatgctata ggcaaaaaaa aacggagctg
    16021 ctgcgccgtg cctttatttc tgcatctcgg tttgccgttt ttattgagga gaccaaaggg
    16081 actccataca cttgctttcg atttggcaaa aactatcccg aaaaagaagg aacacttcaa
    16141 gtattgagca tgatatcaaa ttcggcgatt atatgtatat tgccattggg ttttttgatc
    16201 atggcgtttc ccgtaaaatg gaagaggtac taaagcgtta cagagaccga aaaggattaa
    16261 ttcttgattt gcggaacaat acaggaggta gtatagaaga atgcatgaaa atttccagat
    16321 tactccttcc ttcatgtgat attgcagagt tgcgctatcc gggtaaaacc ataatttata
    16381 cgtccgacga ggccagattc ggttttcagc gcatctttat tttggttaac ggatacacag
    16441 ccagctgcgg tgaaatattg gcattgacgc tgagagccca tttaaatgaa gcggcagtta
    16501 taggaaaccg gacagcgggc aaggatatcg ggcagcggac attcaatcat agaaagaaaa
    16561 gaatactatt cagtgtttcg tccttttatt ggacagttga gggggaaaca gccataagct
    16621 tgaggaatat ttggaaaagg acaacccgtc cggtatatcc ttcctatcag acgatgatta
    16681 ttacagacat atccatttta tcgactcttt cgctgcaggt ggtcaggggc aggaatatgc
    16741 cggagaacgg taaacccgct tgttacttca tagcagttca gagcaggctt ttgaacggta
    16801 acgccgtgcc gggcatcaaa aaaacatgct gccggtaaaa tagccgggaa cccatccaaa
    16861 actatttctt tttccgggta ccggcgtaga aaccgtagac aacaattaaa gcaatgatga
    16921 tgggaaacca aacggaatca aacataatca atcctccttt ggggattttc actaattata
    16981 ataatatgaa atgaaggaaa tataaatata atgataatga aatcattaaa ctattcctta
    17041 ataatccgcc ttgcaactgc aagttcaaac cttccacccc tttcaggaat ctaatgactt
    17101 ttagattttc cccaactttt tttcggtgag atgaatagtg ctaattcatg tatccatttt
    17161 ttcaatattt ggatatcgca aagaaagcgg aaagagcgtt tttggcacat aacgggcttt
    17221 aaacgctctt tttgtttttt ttgagcattc agctgccagg tcccccaatt atctctttga
    17281 tcagattggt tttccggcat aagatatatt ttcgtttgaa gtaggccggc ttgctggctg
    17341 actgtattgt actgtactgt tcctgattgg agaatgacgc aaagaggcct ggagagatat
    17401 cctgcataca cacaaaaagg aaaatattag tgattagtga gttctatcac aggcgcctca
    17461 gcattagtca aggtatgatc atcttaagaa ccagatattc aacctgataa aaattgaata
    17521 gaaaactgag tagagatcag ggaaagaggt gcgattcctc tacaggccct agctactgtg
    17581 aagcggacga aatccccttg atgtcactgg aacatttccg ggaaggcggg aaactagaat
    17641 gatgcaaagt caggagacct cctctattca gcctatgcag caacttctaa gggaacagtt
    17701 gtctattgca atgaaaccag ggcacaagtg tgttcaaaaa gcacttggaa acggtatttc
    17761 tgacgtatgg acacgaaacc ttaaagtttc gtgttttttt gttcctttta ctcgggaaag
    17821 gagaggaaaa gatgagttac ataaaagacc caaagcttat tgaagaaaaa agttttgaga
    17881 tcatacagga aatcattaca caaacaagac ctgaatatgc cttccggaat agggaagagg
    17941 aactggtaat gaaacgggcg attcatacga cggcagattt tgattatttg gataaccttg
    18001 tttttactca tgatgcattg gcgaaaatac gcgaaacaat caggcatggc ggaatgattt
    18061 ttacagatac caatatggcc ttgagcggga tgaataaaag gattttagat caatacggct
    18121 gccggtaccg ctgctacgtc aatgaacctg aaacagcaga aatcgccaaa cagcaaggca
    18181 tcacccggtc tatggccggg attcaacttg ccgcaaggga agaggaacgg aaattatttg
    18241 taattggcaa tgcgcctaca gcagtctaca aaattttgga aatggaagat gccggtaaat
    18301 tggatgcgga ggctgtagtc ggagtgcctg ttggatttgt cggggcagca gaatcgaaag
    18361 aagccctcta tgaaagtgat ataccggcgg tagttgcccg tggacgaaaa ggcggaagca
    18421 atttggctgc agccatcatt aacgcagtgc tatatgcgat gtaagagaag gtggccctat
    18481 gggagactat gtgtatcatg agggaaaaaa attacgcaag ggttatacga cgggcacttg
    18541 tgcagccgca gcagccaaag cggctgccgc catggtgatc aaacaggaga aaatagcggg
    18601 agtttctgtg attacggcaa acggaacatc tctgcaaatt cccgtgaaaa aacaggaatt
    18661 tgatcagcat accgcgacgg ccgccgttca aaaagatggc ggtgatgatg tggatgcgac
    18721 gcatggaatg tggatttttg cgaaagtaac cttaaacgcc ggcggggaaa tcagactcga
    18781 cggtgggcaa ggaatcgggc gtgtgactca aaaaggcatt gcggtcccgg ttggggaagc
    18841 ggctatcaat ccgataccac gcaaaatgat tatcgcagcc gtccgggaag agattggtgc
    18901 aaagctgggc gcggatatca tcattttcgc accggaaggt gaagaacgtg cggagcggac
    18961 aatgaatagc cgcctgggga ttatcggcgg aatttccatt ttaggaacga caggaatcgt
    19021 aaccccaatg tccgacgagg ggtggaaacg gtcgctttcc atggaactgg aaatgaaaaa
    19081 agcacaagcc ttccggaaag tgattctggt accggggaat tatggagaac gtttcgtgga
    19141 agagcatctt ggcattgacg gtaaatacgt ggtttccatg agcaactttg tcggttacat
    19201 gttaaaagag gcgcagcgcc ttgcttttaa gcacgtgctt ctggtgggcc attttggcaa
    19261 attaattaag gtctccgccg gtattttcac cacatacagc aaagatgccg atgcacgggc
    19321 agaaattttg gtagcaaacc tggctcttgc cagtgcgccc gtccctttac tcgagagaat
    19381 tgcagcatgc acgacaacag aagccgcagg agaaatcatg gtggcagaag gatacagcga
    19441 agtttttcag accattacgg ataaagtgaa gaaacgggcg gaagactttt tgaaattcag
    19501 caaacccttt gttgatattg atgtcatcac tttttcaaca gaacgcggaa tgctggcttc
    19561 aacttgtgat atttcagcaa tcagggaggc atggcgatga ttcatattgt cggaattggt
    19621 ccgggtaaac cggaactgat gacaagtgcc ggaatcatac tcatacagaa tgccgatgta
    19681 attatcggct cgaagcggca gctgaatgaa atcccgcatg acataccggc cgaacgcaaa
    19741 cttcttccct caaatctctc ggaactggaa acatttttgc ttgggaagac tggacaggac
    19801 atcgtgctgc tggcttccgg agatccgtta atgtatggga tcggaaattg ggcgttaaag
    19861 aaatttccga aagaacagct tcagattgta cccggcatta gctccattca gtatctttgc
    19921 acccgttgtg gtattgccat gaacgacctg tacatgacca gcagccacgg aaaacagcct
    19981 gacttcgaat ttctgctcgc acacccgaaa gtggcgatgg taacagacag caagattgga
    20041 ccggcggaaa tagctaagga aatcctccaa cggaaattga acaagaagct cattatcgga
    20101 gaaaatctca gctatcccga tgaacggttg cacctgttaa aaccggaaca agtggcggat
    20161 cattatgaaa tgaatgtggt ggtgatctta gatgagggat gaagttttta ttcgtggtaa
    20221 aacgccaatg accaaagcgg aagtccgtgc agtatccatt gacaaattat cgatagatgg
    20281 aaacagccgc cgttttttgg acgttggagc cggtacgggg agtgtggccc ttcaggttgc
    20341 gagaatgttt ccccatgtgt ctgtaactgc gattgaacga agcggggagg ctttggcatt
    20401 aatagaacaa aacaggcagc agctgctgct tgaaaatgtg gatattattt cggcagaggc
    20461 ccccataccg cttgaaaata ccgtttttga cgctattttt atcggcggga gtggagggaa
    20521 attggcggag atcatagatt ggagccatac cttgttaaag ccgggcggcc agcttgtgct
    20581 caatttcatt ttggcagaaa atgtcctcga agcagcagcc tgtctggaaa aagggccctg
    20641 gcatgaagta gaggtgatcc agctgcaagt ttcaaagtgg catgaacttg gaaaagggca
    20701 ttactttaag ccccaaaatc cgacctttat catagcttgc caaaaagaaa ggagcgggac
    20761 agcatgacga a
//
