LOCUS       NZ_CP020557            10195 bp    DNA     circular CON 24-JUL-2024
DEFINITION  Paenibacillus larvae subsp. pulvifaciens strain SAG 10367
            chromosome, complete genome.
ACCESSION   NZ_CP020557
VERSION     NZ_CP020557.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus larvae subsp. pulvifaciens
  ORGANISM  Paenibacillus larvae subsp. pulvifaciens
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 4666454)
  AUTHORS   Dingman,D.W.
  TITLE     Paenibacillus larvae genome sequencing
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4666454)
  AUTHORS   Dingman,D.W.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-MAR-2017) Entomology, CT Agric Expt Station, 123
            Huntington St, New Haven, CT 06504, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: FEB-2016
            Assembly Method :: SMRT Pipe HGAP assembly v. February-2016
            Assembly Name                     :: sag10367-hgap-022916
            Genome Coverage                   :: 214.2x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002082155.1-RS_2024_07_24
            Annotation Date                   :: 07/24/2024 02:27:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,275
            CDSs (total)                      :: 5,166
            Genes (coding)                    :: 4,634
            CDSs (with protein)               :: 4,634
            Genes (RNA)                       :: 109
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 532
            CDSs (without protein)            :: 532
            Pseudo Genes (ambiguous residues) :: 0 of 532
            Pseudo Genes (frameshifted)       :: 400 of 532
            Pseudo Genes (incomplete)         :: 184 of 532
            Pseudo Genes (internal stop)      :: 26 of 532
            Pseudo Genes (multiple problems)  :: 72 of 532
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:07:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3026269
            Orig. end                         :: 3036464
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP020557.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Dr. Adriana Alippi,
            CIDEFI-CIC, Facultad de Ciencias Agrarias y Forestales, Universidad
            Nacional de La Plata, 1900 La Plata, Argentina.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10195
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="14"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10195
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10195
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5195](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5195)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(915..2066)
                     /gene="yhbH"
                     /locus_tag="B7C51_RS16170"
                     /old_locus_tag="B7C51_16165"
     CDS             complement(915..2066)
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="yhbH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013917185.1"
                     /locus_tag="B7C51_RS16170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_16165"
                     /product="sporulation protein YhbH"
                     /protein_id="WP_083040868.1"
                     /transl_table=11
                     /translation="MAEPLFIVSRENWSLHRKGYQDQTRHQQKIKDAIKQNLPDLVTEE
                     NIILSNGKQIIKIPIRSLDEYRFRFNYNKSKHVGQGDGDSQVGDVLGIDPYTQQGKGAG
                     AGDQAGEDYYEAEVDMEELQSLLFEELELPYLNPKERLDICTQDIIFNDIRKKGIMSNI
                     DKKRTILENIRRNASSGTPGIHGISPDDLRFKTWDEIEKPHSNALILAMMDTSGSMGSF
                     EKYIARSFFFWMTRFLRSKYEHVDIVFIAHHTEARIVSEEEFFTKGESGGTICSSAYQA
                     ALDVIDRSYPPSKYNIYPFHFSDGDNLTSDNERCVKLIQRLMERSNMFGYGEVNQYNRS
                     STLMQTYRHIQDPKFLYYIIREKGEVYKALKTFFAKPEGAAVQ"
     misc_feature    2575..2590
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.27"
                     /tool="antismash"
     gene            complement(2668..3327)
                     /locus_tag="B7C51_RS16175"
                     /old_locus_tag="B7C51_16170"
     CDS             complement(2668..3327)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="B7C51_RS16175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_16170"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_083040869.1"
                     /transl_table=11
                     /translation="MNSLNIYLDHFAFGKQPIFVKQEVSVTKGNIVGIIGENGIGKSTF
                     VNLLAGNITSTLQINYHNKSLVPGYNPFVFFQPDDFTGLEYLTTLEVNQYFLLLYGEEF
                     DQEKFDLLVQVANIQKEKVLKEYIKNLSKGTRQKVVFIIYMMASRDIIIFDEGLENIDV
                     DSLASILAYLKKWVKIENRLCLIATHSTTILEYADQFLHLVREKDGTTMITPLPSG"
     gene            complement(3497..4573)
                     /locus_tag="B7C51_RS16180"
                     /old_locus_tag="B7C51_16175"
     CDS             complement(3497..4573)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS16180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B7C51_16175"
                     /product="hypothetical protein"
                     /protein_id="WP_158530403.1"
                     /transl_table=11
                     /translation="MFIKDALFELNGIILILINLVILLEIKVLAILLLLFISQAFKSTS
                     GQTFLLVLYSMLYAFPIFYFHSTYLAVFTIFAGFFVVCFALYFCVYLIGARNRNMKGTK
                     GRWFLIFMDIQCLTRRLVETKISLIRFAFPPYILLYVSLFWVLDMFPSFFAQFSIDKDM
                     LVSLSLVLYVGIYFIYTKTSILLLDDYFYFSATKIELYATNFVFSYFRKITVLLVFNVF
                     NIFWGLCYLNLVLKMNGDLAKIGLMFFLHLFMLPLFVSANIFVDKNKAEVAQYPEDFKK
                     YVSFTETFFISILFLLIHLFILMHFDPRTAVLITSHLFDINIYLIGTLVVISGTISIVK
                     TLTHMGVVRKSIKRGVYK"
     misc_feature    complement(4799..4812)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.91"
                     /tool="antismash"
     gene            complement(5001..5195)
                     /locus_tag="B7C51_RS16185"
                     /old_locus_tag="B7C51_16180"
     CDS             complement(5001..5195)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03651"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS16185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B7C51_16180"
                     /product="hypothetical protein"
                     /protein_id="WP_036656171.1"
                     /sec_met_domain="TIGR03651 (E-value: 1.1e-05, bitscore:
                     23.8, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFELIATGISAGNAAQVVNAVFNGVSIVSALSLYAGIAGGLAWFL
                     SNGLRHMIKWAGKKTIIDW"
     misc_feature    complement(5400..5419)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 20.02"
                     /tool="antismash"
     gene            5717..5977
                     /locus_tag="B7C51_RS26020"
     CDS             5717..5977
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS26020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_158530404.1"
                     /transl_table=11
                     /translation="MYRIIAHELVNIKVHDVAENKLTMATVEKMSFDPTDIKYISFINF
                     LSPFFLNTILNININNSLAKIKNTERRNTVNIELTIATTVI"
     gene            complement(6131..6649)
                     /locus_tag="B7C51_RS16195"
                     /old_locus_tag="B7C51_16190"
     CDS             complement(6131..6649)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014052.4"
                     /locus_tag="B7C51_RS16195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_16190"
                     /product="stage II sporulation protein M"
                     /protein_id="WP_172422944.1"
                     /transl_table=11
                     /translation="MKAYISVEHKVAIFLIGLSILVGFIYGYFFEDISQIKIKSFDGLN
                     FIETFLQIFFHNFSIGLIIIFCSIFFYVVSAIPVIATYFVFGESFVFILKKEGFIAAIT
                     TYPHFLPETLSTMLLLSIAFVISTKMLKIVFRNESILKNKKKILKTYLVSNVLLIFAAL
                     IEALKICYF"
     gene            6934..7236
                     /locus_tag="B7C51_RS27710"
                     /old_locus_tag="B7C51_16195"
     CDS             6934..7236
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS27710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B7C51_16195"
                     /product="hypothetical protein"
                     /protein_id="WP_083040873.1"
                     /transl_table=11
                     /translation="MSTNVSRDLDTFLMRGKNGISEQSKQIIHDFIHALTSHEDLNPKT
                     LKEYASDLKHFIGWFGQPITKKKKSYFSNIINTTMIYVKATRSDLQAEVEKIAWR"
     gene            complement(7550..7993)
                     /locus_tag="B7C51_RS16205"
                     /old_locus_tag="B7C51_16200"
     CDS             complement(7550..7993)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016123621.1"
                     /locus_tag="B7C51_RS16205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_16200"
                     /product="VOC family protein"
                     /protein_id="WP_023485365.1"
                     /transl_table=11
                     /translation="MAKLSPYFAFENAKEAMSYYEKVFGATHLARIPVGKEMAKQFNIP
                     ENQIEHSTMHGSFSIEGNLILCSYSFGRKITPNEFVSMLIDFNSEDSEDEQKMIDLYNR
                     VVESGEVNVTMPLQKQFWGGKMGTFTDKYDITWMLHSQPYSKM"
     gene            8350..8721
                     /locus_tag="B7C51_RS16210"
                     /old_locus_tag="B7C51_16205"
     CDS             8350..8721
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009677133.1"
                     /locus_tag="B7C51_RS16210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_16205"
                     /product="DUF423 domain-containing protein"
                     /protein_id="WP_023485364.1"
                     /transl_table=11
                     /translation="MYKIFLLLGSINAFLSVALGAFGAHILKSRIPANMLANYETGVQY
                     HMAHALGLILVAILADKLGQGGLITWAGWALFIGIIFFSGSLYVMALTGVRTLGAITPI
                     GGMAFLTGWILLAVSAFRS"
     misc_feature    complement(8953..8968)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 23.65"
                     /tool="antismash"
     misc_feature    9631..9645
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: strong, score: 21.57"
                     /tool="antismash"
ORIGIN
        1 taaagtgtgc ttggaaggct gaacaacaga tgagttgagt ttagagtact cgatcgtttc
       61 ttcttcagtc aggtccagtt cccttagtat gcgctgatgc caatatgagg cccagccttc
      121 attcatgact tttgtttcca tttgcggcca gaaatacagc atttcatccc gcatcatcgt
      181 cataatatcc cgctgccagg gttccatgta cggggcgttt tcttcgataa atagcagcag
      241 atctttttcc ggctgggccg gaaaacgggg ttcgtcctct tcagcctgct tgttatcagg
      301 ttttatatcc aagtcccaaa ggtcttcata tccggtttga acctctgtct tcttttgctt
      361 ctcgtcctgc cagttccttt tccagcggtt tcgccgttct atctgttcat aaggggtgat
      421 gagactaggg tccacatgct cttgaatagc cagtaccgca tcaaggaacg tttcgacttc
      481 ggctgctcca tactcaattt catactgccg gacccgctct gctgtagccg acatgctttc
      541 taccatattg cggtttgtac gggaaaagtg aacattgttt ttgaaaaaat cacagtgcgc
      601 taaaacatgg gctacgataa gtttgttctg aataagggaa tttccctcaa ggagaaaggc
      661 gtaacagggg tctgaattga tcacgagttc ataaattttg ctaagcccaa ggtcatattg
      721 catcttcatt ttatggaaat ttttcccgaa gctccagtgg ctgaagcggg tgggcatacc
      781 ataagccccg aatgtataaa tgatttcagc cggacagatt tcataacgca tagggtagaa
      841 atccagcccg aatccgctgt ccacttcgct gatttcggca atagcgtatt ccagctgccg
      901 cttttcggat tctttcactg taccgcagcc ccttccggct tcgcgaagaa ggttttcagc
      961 gctttgtaga cctcaccttt ttcacggata atataatata aaaacttggg gtcttggata
     1021 tgccggtaag tctgcattag tgtactgctg cggttatact ggttcacttc cccgtacccg
     1081 aacatattcg aacgctccat aagccgttga atcagtttga cgcatcgctc attatcggag
     1141 gtcagattat ctccgtcaga aaaatgaaac gggtagatat tgtatttgga cggcggatag
     1201 ctgcggtcga tcacatctaa agcagcctga taggctgagg agcagatggt tcccccgctt
     1261 tcgcccttag tgaaaaattc ttcttcggat actatccttg cttccgtatg atgagcaata
     1321 aagacgatat cgacatgctc atatttgctc cgtaaaaaac gcgtcatcca gaagaaaaaa
     1381 ctgcgggcaa tgtatttctc gaaggaaccc atacttccgc ttgtgtccat cattgccaga
     1441 ataagagcat tggaatgcgg cttttcaatt tcatcccaag ttttaaaccg cagatcatcc
     1501 ggtgaaatac catgaatacc gggcgtcccg gaagaggcat tgcgccggat gttctccaga
     1561 atcgttcttt ttttatcaat attggacata atgcctttct ttcgaatgtc attaaaaata
     1621 atgtcctgcg tacagatatc aagccgttcc ttgggattta gatagggcag ttccaattct
     1681 tcgaacagca acgattgaag ctcttccata tctacttccg cctcgtaata atcctcgcct
     1741 gcctggtctc cggcccctgc cccttttcct tgctgggtgt aaggatcaat accgagcaca
     1801 tccccgactt ggctgtctcc atctccttgc cccacatgtt tacttttatt gtaattaaag
     1861 cggaatctat actcatctag actgcggatc gggattttaa taatctgctt gccgttcgaa
     1921 aggataatat tctcttcagt aacgagatcg ggcagatttt gtttgattgc atcttttatt
     1981 ttttgttgat gccgggtctg atcctgatag cccttccggt gtaaagacca gttttcccgt
     2041 gagacgataa acaaaggttc cgccaataga ggtcaccccc tcaaagtgta gcaaaccgca
     2101 aaaaactgga tttttggttg ttttatgaaa agaatctatt actaaatata ttcaaccggg
     2161 gaatggttat gtgagaagga tgctggccta atttccggga ctatgtgatg taaatccggc
     2221 tgcagtcaac taaccaccgg actctaaaga agaacttaca tccaactttt tcctgcattt
     2281 tatcgttcct gaaaagtggg attgtgtatg gaagcctctg gaataggcta aaggacacgg
     2341 agtaagtgaa gacgaaatac atatcatgca taaacaggcg caccggctta tcatggaggc
     2401 ctgtgttcct ccgattcatt ttgaaggaag caggaaacta ctccgaaaat cggaaaagat
     2461 gactgtaatc ggacattttg gccgaggtgg ttcatgaaat tcgtatgaga tggaaaggta
     2521 attgtcccca gtttattttg aaaagaatca ttctttcatt ctcttacctt tgtatccact
     2581 ttttcttgac gagcccaaga tcatctgtct atttaaaggg gagcatatta cattaagcct
     2641 gcgggccaat tatcaatttt atgatcctta acctgatggg aggggcgtga tcatcgttgt
     2701 cccatctttt tctctgacta agtgtaaaaa ttgatcggca tattctaata tagttgtgct
     2761 atgagtagca atcaaacata gcctgttttc gatttttacc cattttttaa gataggccaa
     2821 aatagaagct aaggagtcca catctatatt ctccagcccc tcatcaaata tgataatgtc
     2881 cctgcttgcc atcatataga taataaatac aaccttttgc cgggttcctt tagacaggtt
     2941 cttaatgtat tccttcaata ctttttcttt ttgaatgttg gcaacttgaa caagcaaatc
     3001 aaatttttct tgatcaaact cctccccgta aagcaataaa aaatattggt tcacttccaa
     3061 agtggttaaa tattcaagcc ctgtgaagtc atccggctgg aaaaaaacga aaggattata
     3121 accgggaact agcgatttat tgtgataatt tatctgtaat gtggacgtaa tgtttccagc
     3181 cagtaaattg acaaaggtag atttcccaat tccattttca cctataatac ctacgatatt
     3241 ccctttcgta acagaaacct cttgcttgac aaaaataggc tgcttcccga aagcaaaatg
     3301 gtctagatag atatttaaac tgttcattcg tcaatcccca ttaacattaa gaataaagcg
     3361 gcaatagagg ttattagtga tgtgaaggac aaaaataaaa ttaaataatt cataggtttt
     3421 ccttttttaa aattaataac ttcctttagc aacaaatgca cagaaaagag tacgagaaaa
     3481 attaagccat atagaatcat ttgtaaactc ccctttttat tgattttcga acgactccca
     3541 tatgagtaag agtttttaca atggatattg tcccactaat aacaacaaga gtacctatta
     3601 gataaatatt aatatcaaaa agatgtgatg taatcagaac tgccgttctc ggatcaaagt
     3661 gcataaggat aaataaatga attaaaagaa ataatataga tataaagaaa gtctctgtaa
     3721 aactcacata ctttttaaaa tcttccggat actgtgcaac ctcagctttg ttcttatcga
     3781 caaaaatatt agcagataca aaaagcggta gcataaacag atgaaggaaa aacatcaacc
     3841 caatctttgc aaggtctcca ttcattttta ggaccaagtt caaatagcac aggccccaaa
     3901 aaatgttaaa cacattgaaa acaagtaaaa ccgtaatttt tctaaaataa ctgaaaacaa
     3961 aattagttgc atacaattcg attttggttg ccgaaaaata gaagtaatca tctaaaagaa
     4021 ggatagaggt tttggtataa ataaagtaaa tgccaacata taaaaccaaa gataatgaaa
     4081 ccagcatatc tttatcgata gaaaattggg caaaaaatga tggaaacatg tctagaaccc
     4141 agaacagaga aacatataaa aggatgtaag gtggaaaagc aaaacgaatc aaggatatct
     4201 tagtttcaac taatcttctg gtgaggcatt gaatatccat aaatataaga aaccatcttc
     4261 ctttcgtccc cttcatgttc ctattccttg ctccgattag atatacacag aaataaagcg
     4321 caaaacaaac aacaaagaaa cctgcaaaaa tagtaaaaac agctaggtat gtactatgaa
     4381 aatagaaaat ggggaatgca tacagcatcg agtataggac caataggaaa gtttgtccgg
     4441 aggtactttt aaaagcctga gaaataaaaa gcaacaggag aatagctaaa accttaattt
     4501 ctaataatat gactaagttg attagaatca gaatgattcc atttaactca aataacgcat
     4561 ctttaataaa cactttatgc atccatcttc taataggcag gattttgaat tccttcactt
     4621 tataaaggta ggagatgaat aaaaggagaa gaagaacata tttcaagaat agtggatacc
     4681 aaaaaatggt taaagggaac gcgcacttaa aaaaagtttc tgacaaagtg aagcatgtgc
     4741 ttaacattct gcaaatgtta gtaggtaaat aagtaaattc gtcactgaaa aatctcattt
     4801 tttttgaaaa atgaagtcga taatgctttt ttataaaaag aactaggtat tgcaatatat
     4861 aaaaaagctt tttgggaaca ttcataagac ctccaaaacc tcttaatcca tatttgcatt
     4921 gaaattgatg aataaataaa ataaaacaag ggatttaagg gattatcatt gagtttggta
     4981 atcccttgtt ttatggttaa ttaccagtca atgattgtct ttttgcctgc ccattttatc
     5041 atgtgcctta atccattaga taaaaaccat gcaagaccac ctgcaattcc agcataaaga
     5101 gataaggccg acacgataga tacaccgtta aaaaccgcgt taactacttg agcagcattt
     5161 cctgcagaaa taccagttgc aattaattca aacaagttct cacccccctc gtaggttaat
     5221 ctgatttata gacaaggcat aaagcctcgg ctaccataca aataaaggcc atctttttca
     5281 ggaagattca attacctcct aggtttttca ttggaggttg ttttcatgta ctttgtcggt
     5341 attgacctag ctgatcaata acatgatgtc tgcatttgcg aggataccgg agctatgatc
     5401 tagggcttat cgttccccaa actcccgaag attgaacgac ttactcaatg tctttcgtaa
     5461 tcttgatcag agcaagattc tcattgcaac tgaaacgccg cttaacacac aatctccttc
     5521 tcggcacttc tagtttccta ttatcttttt tcgaatttgc agtttgcttt aagttccgct
     5581 ttttcaaaag attatattga ttaagggcgt ctttcaaata agtaagatca atagacatcc
     5641 cgtgattagt tgaaaaatat tttctttttt agttcgtcct gagatagtgt tttgtttatt
     5701 agcaaaaaga taaataatgt ataggataat tgcacatgaa cttgtaaata taaaagtcca
     5761 tgatgttgct gaaaataaac taacaatggc tactgttgag aaaatgagct ttgacccaac
     5821 agatataaag tatatttcat ttattaactt cttatctccc ttctttttaa atacaatttt
     5881 aaatattaat attaataaca gcctcgctaa aattaaaaat acagaaagga ggaacactgt
     5941 aaatattgaa cttaccatag ctacaacagt catctgatta tgagtcaaac tgataccttt
     6001 agtaattgca tcattgaaaa tttctgattt tcttactgta gagtttataa ctatggtagt
     6061 taaaatgttt acaaaaagaa tcaagaagaa tactgtctta tactttttca ttttcattaa
     6121 ttaacccctt tcaaaaatag caaattttca aagcttcaat taaagcagca aaaatcagta
     6181 acacattaga aacaagatag gtttttaaaa tctttttttt gttctttaga atggattcat
     6241 ttctaaatac aatttttaac atttttgttg aaataacaaa tgctattgag agtaataaca
     6301 tggtggaaag tgtttccggg aggaaatgtg gatatgtagt tattgcagca ataaatcctt
     6361 ctttctttaa aataaaaaca aagctttctc caaaaacaaa atatgtggct attacaggaa
     6421 ttgcagatac aacatagaag aagatagagc aaaatattat aatcaaacca atggaaaaat
     6481 tgtgaaagaa aatttgtaaa aatgtctcaa tgaaatttaa cccatcaaaa cttttaattt
     6541 tgatttgact tatatcttcg aaaaaatatc cgtaaataaa acctactaaa atacttagac
     6601 caattaagaa gatggctact ttatgttcaa cagaaatata agctttcata ttcacctcac
     6661 caaaaatctt ttttttcatg gttgcttcta tgtaagtagg atgaaatatt taatcaaaca
     6721 taccaaatcg ttgaacttat tcggagttag agacaaaaat ttagaatatt catatgacac
     6781 atatatgaat ttataccata tatatacatt gatagtaaac attttatatg aaaataactt
     6841 ttcctaagct tccctgttgg atagtatctg cttgtgatgt gatatttgag caaattccaa
     6901 caggttagct tagccatttt aagatgtgta aacatgtcca ctaatgtaag tagagatttg
     6961 gatacttttc taatgagagg gaaaaacgga atttcggaac aaagtaaaca gatcattcat
     7021 gactttattc atgctcttac cagccacgaa gatttgaatc ctaaaacact aaaagagtac
     7081 gcaagcgatc taaaacattt tatcggttgg tttggacagc caatcaccaa gaagaaaaaa
     7141 tcgtatttct ccaacattat caatacaacg atgatttacg tcaaggcgac tcgttcagat
     7201 ctgcaagctg aagtcgaaaa aatagcttgg cgatgagaga acagaaaata aaaagccgac
     7261 atatgcgagg caacttcagt agaatgtttt cgctcctttt taattctcct agtaatgata
     7321 atattccctc gtagggacaa attaccttag aagctgtaac ggtgtctttg ctgaatattc
     7381 ttggagggga tacaacaaat aaaagatgtt acgaaaactt ttgatcacat ttttgcagtt
     7441 acgaattttc aaaatactca ttagattact atcgattgct cactatatat agaaaaaaga
     7501 caaactctct aaggtgagaa gtttgtccta aaactttatt cgttctctct tacatctttg
     7561 aatatggttg tgaatgtaac atccaagtga tatcgtattt atcagtaaat gtccccattt
     7621 taccacccca aaattgcttt tgtaaaggca tggttacatt tacttctcca gattctacca
     7681 ctcgattata taaatcaatc attttctgtt catcttctga atcttcacta ttgaagtcaa
     7741 tcagcatgct aacgaattca tttggtgtaa ttttacgtcc aaaactatat gaacaaagaa
     7801 ttaaatttcc ttcaatagaa aaagaaccat gcattgtaga atgttcaatc tgattttctg
     7861 gaatattaaa ttgttttgcc atctcttttc ccacaggtat tctggcaaga tgagttgctc
     7921 caaacacttt ttcataataa ctcattgctt cctttgcatt ctcaaatgca aaatatggtg
     7981 ataacttagc cattctttct taaataattt aataaacaat agtaatttac ttctataagt
     8041 atactttttt tcgttctact aagctaatgt taaacccttc cacagtacag gttcgttttt
     8101 ttcaaaatta gggcttgatc cggaatgttc agcaagccct gatttggaat agacatgtca
     8161 ggggcttttt tcaccatctt ttttgaagga attgatcagt aggccgaaga ataggtatcc
     8221 taactacggc ctcaggcgga gggatcatgc atctctttgc ttgccgtgga aacttcctcc
     8281 aggataagct aaactgtatt tgtaaaagat ggcttgtata caaccaggtt cagcaaagga
     8341 gagagtttcg tgtataaaat ctttttactg ctcggcagca tcaatgcttt tttatcggtg
     8401 gcccttggag cttttggagc ccatatattg aaatccagaa tcccggctaa tatgcttgcg
     8461 aactatgaaa ccggcgtcca gtatcatatg gcccacgccc tgggtcttat tttagtcgct
     8521 attctggcgg ataaactcgg gcagggcggg cttattacgt gggcaggatg ggctcttttc
     8581 atcggtatta tttttttctc gggaagttta tatgtcatgg ctttaacagg tgtaagaacc
     8641 ttgggtgcca tcactccgat tggcggaatg gcttttctga caggatggat attattggca
     8701 gtgtctgcat tcagatcata aagaaggatt ttccagaaaa ggcagcgaaa tttagacata
     8761 atgaacaagc atttatcttt tgaaagggac gtcaaccatg acacatttca gaagccatca
     8821 tccttgggaa taccatgaat acggcaaata tcgcggattg gaccaagatt cccgacggga
     8881 agaaagtcat ggaaagctgg atgagctgtt caaacagtct tttgaccagg cggctaccgg
     8941 tttcgctgtg ctaacccccc aggggaaata cctgatagtc aatcagacat tatgtgagat
     9001 gcttggttac tccgaatctg aacttctcac ttcttatttc caaatgttct cctatcccga
     9061 tgacctgcat caggacctga tctatctgaa agagatgctt gaaggaaagc gcacttgtta
     9121 tcagatggag aagcgctgcg tgcataagtc ggggtcttta ttatgggtac ttttaagtgt
     9181 atccgtgatc agggatggac aagggaagcc tcaatatctg gtctcccaga tgcaggatat
     9241 cacggccggg aaaaagatgg agaagcagct cttggacgag caaaaaaggt atctggcctt
     9301 gctggaatat atcccagaca tgatctgttt tttggattac acaggaagac tttgtgatgt
     9361 aaatcctgct gcagtcaagc tgaccggata ctctgaagaa gaacttacct caaacttttt
     9421 cctccgtttt atcgtgcctg aagagtggga tcgggtatgg aatcttctgg aagaggctaa
     9481 aggataccga gtaagtgaag gcgaaataca tatcatgcat aaggaggggc accggcttat
     9541 catggaggcc cgtgcaattc cgattcattt tgaagggcag caggaagggg tatatttaat
     9601 agccagggat gttactgaac gtaaaaaaac ggaagaactg ttccgaaaat cggaaaagct
     9661 gactgtaatc ggacaaattg cagccggagt ggctcatgaa attcgtaatc cccttactac
     9721 gctgaaaggt tttatccagc ttttccacgc aggagaagag gggaaacagg aatattatga
     9781 ggttatgatg ggagagctta accggattga actgataatt acggaaatgc ttgtactggc
     9841 caagcctcat atgtcccatt ttcagccaag gcatattgac aaaatcattc agaatgtcct
     9901 catcctgctg gatacagagg caaaacataa aaacatacga attgtagttg cgggagaagc
     9961 agatttggca ccggttcttt gcgaagaaaa ccagcttaag caattattta tccatctgct
    10021 gaagaatgca gtagagtcaa tggaacatgg ggggaaaata ttaattcaaa tcagagggca
    10081 cggaaaagac cgcatttgtg taagaattac ggatcagggt tgcggaatcg ctccggagca
    10141 aatgcacaag ctgggtgaac cgttctatac aacaaaagaa aaaggtacag gcctc
//
