LOCUS       NZ_CP020557            10222 bp    DNA     circular CON 24-JUL-2024
DEFINITION  Paenibacillus larvae subsp. pulvifaciens strain SAG 10367
            chromosome, complete genome.
ACCESSION   NZ_CP020557
VERSION     NZ_CP020557.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus larvae subsp. pulvifaciens
  ORGANISM  Paenibacillus larvae subsp. pulvifaciens
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 4666454)
  AUTHORS   Dingman,D.W.
  TITLE     Paenibacillus larvae genome sequencing
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4666454)
  AUTHORS   Dingman,D.W.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-MAR-2017) Entomology, CT Agric Expt Station, 123
            Huntington St, New Haven, CT 06504, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: FEB-2016
            Assembly Method :: SMRT Pipe HGAP assembly v. February-2016
            Assembly Name                     :: sag10367-hgap-022916
            Genome Coverage                   :: 214.2x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002082155.1-RS_2024_07_24
            Annotation Date                   :: 07/24/2024 02:27:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,275
            CDSs (total)                      :: 5,166
            Genes (coding)                    :: 4,634
            CDSs (with protein)               :: 4,634
            Genes (RNA)                       :: 109
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 532
            CDSs (without protein)            :: 532
            Pseudo Genes (ambiguous residues) :: 0 of 532
            Pseudo Genes (frameshifted)       :: 400 of 532
            Pseudo Genes (incomplete)         :: 184 of 532
            Pseudo Genes (internal stop)      :: 26 of 532
            Pseudo Genes (multiple problems)  :: 72 of 532
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:07:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2083906
            Orig. end                         :: 2094128
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP020557.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Dr. Adriana Alippi,
            CIDEFI-CIC, Facultad de Ciencias Agrarias y Forestales, Universidad
            Nacional de La Plata, 1900 La Plata, Argentina.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10222
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="10"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10222
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10222
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5222](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5222)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(439..582)
                     /locus_tag="B7C51_RS25840"
     CDS             complement(439..582)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS25840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_024095476.1"
                     /transl_table=11
                     /translation="MLQNVQKIAPIQQQYGLSSTQMNMEQPLSDPGAMPFKLCKQVHEQ
                     AF"
     gene            complement(831..1661)
                     /locus_tag="B7C51_RS11155"
                     /old_locus_tag="B7C51_11155"
     CDS             complement(831..1661)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005828471.1"
                     /locus_tag="B7C51_RS11155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_11155"
                     /product="aldo/keto reductase"
                     /protein_id="WP_083039950.1"
                     /transl_table=11
                     /translation="MSKHLSDAATLNNGVAMPWLGLGVWNVKEGEVYHSVKAAIEVGYR
                     SIDTAAIYENEEGVGKAIKDSGVQRDHLFITTKLWNTEQGYESTLKAFDVSMKKLGLDY
                     LDLYLIHWPGKGEKFVDTWKAFEKLYKEGYIRAIGVSNFHVHHLNQLMEAADVVPAVNQ
                     VEFHPRFSQVELRNYCKQKGIQLEAWSPLMQGKLLDNPTLKEIGDKYGKSTSQVILRWD
                     LQNEVVTIPKSVNPERIRQNADLFDFELSEEDMERINGLNKDERNGPNPDEFLF"
     gene            complement(1812..2090)
                     /locus_tag="B7C51_RS11160"
                     /old_locus_tag="B7C51_11160"
     CDS             complement(1812..2090)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS11160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B7C51_11160"
                     /product="hypothetical protein"
                     /protein_id="WP_036655571.1"
                     /transl_table=11
                     /translation="MNRTFRYVGYFFGIVMMVCVIFSIKIRDNFYISDYVLGKFHVQSN
                     KIVIVLIFLVSWWICMKTLKGYRPIWLNWTKLFLSVLLLIAFVSYLI"
     gene            complement(2102..2755)
                     /locus_tag="B7C51_RS11165"
                     /old_locus_tag="B7C51_11165"
     CDS             complement(2102..2755)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015593257.1"
                     /locus_tag="B7C51_RS11165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_11165"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_023482279.1"
                     /transl_table=11
                     /translation="MFEIKEINFGYEKDRLLLKNIHLSASPGEIIWLRGANGSGKTTLL
                     RIITQLIETDSQIYFKGRLSQSREEILSQVTYIPSEPYLFDYLTGKENADFFQALFDIP
                     QDHFESFSTMIHQFGMDEALDQFVKDYSLGMRHKLYWSAVFARETSMYLLDEPFSPLDQ
                     DSQEVAMNMLINRAEQGSIILFVSHLNEISRKLATRSLVLENGELRESEVLKEQ"
     gene            complement(2768..3481)
                     /locus_tag="B7C51_RS11170"
                     /old_locus_tag="B7C51_11170"
     CDS             complement(2768..3481)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014052.4"
                     /locus_tag="B7C51_RS11170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_11170"
                     /product="stage II sporulation protein M"
                     /protein_id="WP_083039952.1"
                     /transl_table=11
                     /translation="MPVYVLFFLLGLLSILSRGRSYSMIFSSSCSFCGVLRYFFSIILP
                     GTKNIRMGIAFMNGKMKMGVFKYYWQTYSTKSILIILVFIASFLWGMISQSYQNPLVIS
                     SPNLTWMDYFFHNTKQAFLTILLGFVTYGFGSLALGAISGISAGVGIEITLQNNMGESI
                     ITAFLPHAIFEIPAILLSCLYPFMIWRFITASIKNKNLQYKLVKIELIPILFCIILLFF
                     IAAIMESIFILEIEV"
     gene            complement(5001..5222)
                     /locus_tag="B7C51_RS11175"
                     /old_locus_tag="B7C51_11175"
     CDS             complement(5001..5222)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03651"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016123749.1"
                     /locus_tag="B7C51_RS11175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_11175"
                     /product="uberolysin/carnocyclin family circular
                     bacteriocin"
                     /protein_id="WP_083039953.1"
                     /sec_met_domain="TIGR03651 (E-value: 1.9e-22, bitscore:
                     77.6, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQIAGYLGFSTGMAKKIVDVIDAAGWAFVAVSTIMAILSAGGLA
                     VTSAMIDYAIINVKDLLKRNLKAQAIVW"
     gene            complement(5375..5638)
                     /locus_tag="B7C51_RS11180"
                     /old_locus_tag="B7C51_11180"
     CDS             complement(5375..5638)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009675961.1"
                     /locus_tag="B7C51_RS11180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_11180"
                     /product="hypothetical protein"
                     /protein_id="WP_024095479.1"
                     /transl_table=11
                     /translation="MAKNDSSLQSQNPISQAQNSVEKVHNAISQAMTHPTNQTVNQAYK
                     SIAHAENAVSQAELSHSQEVVEQIRNELELEKEDLSQMRREP"
     misc_feature    complement(5705..5716)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.96"
                     /tool="antismash"
     gene            5875..8874
                     /locus_tag="B7C51_RS11185"
                     /old_locus_tag="B7C51_11185"
     CDS             5875..8874
                     /EC_number="3.4.24.3"
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018670971.1"
                     /locus_tag="B7C51_RS11185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_11185"
                     /product="collagenase"
                     /protein_id="WP_083039955.1"
                     /transl_table=11
                     /translation="MKRIWISILLSGMLLVSSTAVWPSGTVKAQQLSETLAGMMQNDTG
                     TEQLSESNKPEQEVKRLKRQTDQDYSMAYLNSLPYNELVDLLTSSSWTQIPELFKFNPD
                     SRQFYENQDRFQAIIDALQTRGSQFTEDDDKGIPTLVEVLRSGYYLGYYNQELGFLNTR
                     EYKKKVLPAINKMMDNRFFAWGSATQNEVIGAAGKLISNTTVDTETVNRMAGLVKDFVE
                     HVDDYAGDHGKSKAFYDVIQGIGYVLLWDLSEPDKQAIKGNIDAYLNPLFLLAKQGPSS
                     ADKVWLTNNAVYYTGELAHYHSNPDKANQVLTDSMNSQPRLSELFFIAARQISEHYAGK
                     DYNGNRIDLKKLKNEGKTHYLPQRFSFDDGKFIFQTGDQLKEEQIQRLYWAAKEVKAQF
                     HRVVGNDKALEKGNADDVLTVVIYNNPDEYRMNNYLYGYSTDNGGIYIEGIGTFFTYDR
                     TAEQSTYSLEELFRHEFTHYLQGRYEVPGTWGRGPLYESGTMPWFEEGGAEFFAGATRT
                     DSIQPRKSVVGNLRQDSPSQRYSVSQTLHAQYGSWKFYDYSFAMFNHLYQTDLSELNKI
                     NNMIRANDSHGYKDNIEKLSKDEKLNREFQQTIEQQISQYDSLSTPLVSDDYMEVPQPK
                     NTSEIYAEIANAAGLSNVKTEEHESQFFKTFTLQGIYTGGPSKGKVQDWKTMNGLADGF
                     LKSLSGLTWNGYNTVTAYFTNYRVTEDGRFAYDVVFHGKLPEKENPGAGGNPDNGHSGN
                     PNTDNEHNGNLSGDQEPNNTFKQASQLKLKQTVSGTVGGSDYADIYRFEVKHPGQLDIL
                     LEADKEQGVAWLLYHESDLQNYTAYPDKVEGKRLSGSHEAKAGTYYLYVYSTSDENHAY
                     QVSVNPTGETPSIEENEPNDTADKANTFPIGQSVNGKLDGNDRQDVFTFDIHDQSPIRV
                     EMQKLLGENASWMLFKEDDMDHPVSYPTEVSGLKMAGGYDAGPGRYYLFVYKYADEDIQ
                     YNVQIEPVNP"
     gene            complement(8948..9792)
                     /locus_tag="B7C51_RS11190"
                     /old_locus_tag="B7C51_11190"
                     /pseudo=""
     CDS             complement(8948..9792)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009331727.1"
                     /locus_tag="B7C51_RS11190"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_11190"
                     /product="DUF72 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MIQIGLTGWGTMKIYMKGLLNPRIGFLCTAGISLL"
ORIGIN
        1 tccacccagt aagctccacc aaataattga tacatccata catacgtaat gccataaata
       61 ataaatgtaa ggccaagggt aaatagcaga agttctgcca atctcccgta tgtaatggtt
      121 ccttgctgga tcccatccac cactctcccc acaatctgcg gtggaataat atccccaacc
      181 cctactaaaa tcagcaggac tacagcaatc gtatacctct tccaatgctg ccggaaaaac
      241 caccgcaatt tgtacaaaat gcttaacaat atgtccaccc cctatggaaa attcccattc
      301 tttcatcatt cctaactcca cttttccgaa tggacccgtg gataaagaca aaaagagcat
      361 acgtctgctg acatatgctc tgtacaacct cttggacggt aagcacaatt tgctcagcca
      421 attagggaat gcttcccctc aaaacgcctg ctcatgaacc tgcttacaca atttaaaagg
      481 cattgctccg ggatcggaaa ggggctgctc catattcatt tgggtagatg atagtccgta
      541 ttgctgctgg ataggagcta ttttttgcac attttgtaac atgaagacca cctctttcct
      601 tttccatttt cttcaaaatt gatttttaca tgttgtgatt gtaccctgcc ttttggcggt
      661 tgtcaatgag ttctttttct ggaaagttga gtataatttt tctttcctat gcggcattaa
      721 cgcctaaaag ttaacgcatg attaccggtc gttccaacaa catgcatact gccgctctat
      781 aaaaagagcc ctggtccgat gattaccgaa ccaaggcttc tggggtttag ttagaacaag
      841 aattcatccg gattaggacc gttccgttca tccttattaa gcccgttaat gcgttccata
      901 tcttcttcgg ataattcaaa atcaaaaaga tcggcgtttt gtctgatacg ttcgggatta
      961 accgatttgg gaatagtcac aacctcgttt tgcagatccc agcgcaaaat aacctgggat
     1021 gtgctcttcc cgtacttatc cccgatctct ttcaatgttg gattatcaag cagcttaccc
     1081 tgcataagcg ggctccaggc ttccagttga atgccctttt gcttgcagta attgcggagt
     1141 tccacttgac taaaacgagg gtggaattcc acctggttta ctgcaggtac tacatctgca
     1201 gcttccatca gctggttcaa atgatgaaca tggaagttac ttactccaat tgcgcgaatg
     1261 tatccctctt tataaagctt ttcaaaggcc ttccaagtat ccacgaactt ttcgccttta
     1321 cccggccaat gaatgagata caaatccagg taatctagac ccagcttttt catgcttacg
     1381 tcaaaagctt ttagtgtaga ttcgtatccc tgttctgtat tccaaagttt cgttgttata
     1441 aagagatggt ccctctgtac gccggaatct ttgatcgctt tgcctacgcc ttcttcgttt
     1501 tcataaatgg ctgcggtgtc aatgcttcta tagccgactt caatggctgc tttaactgaa
     1561 tgataaactt caccttcttt gacgttccat acgcccagcc caagccaagg cattgcaaca
     1621 ccattgttca atgtggctgc atctgataaa tgtttgctca tgattctacc tcccaaaatg
     1681 gaatgtgaac atatacgttt atcataccac acaaaatttg ggaaaagaat aaattcccta
     1741 gggtatacat gacgacttcc tacgcttaaa ggcaggggct cctcagacca ttgaggttca
     1801 taaaatttaa tttaaatcaa gtacgaaaca aacgcaatca gcaaaagaac ggacagaaaa
     1861 agcttggtcc aattcaacca aatcgggcgg tatcctttca gtgttttcat acaaatccac
     1921 cagcttacta gaaaaatgag tacgattacg attttattgc tttggacatg aaactttccc
     1981 aaaacataat cactgatata gaaattgtcc cttattttaa tgctgaaaat aacacatacc
     2041 atcataacaa ttccaaaaaa ataccccaca tatctaaatg tccggttcac caaatccctc
     2101 cttattgctc cttcaacact tcactttctc taagttcccc attttccagt accaggctcc
     2161 ttgtcgctaa cttacggctt atctcattaa gatgtgacac aaagaggatg atgcttcctt
     2221 gttcagccct atttatcagc atattcatgg ccacttcttg tgagtcctga tcaaggggag
     2281 agaaaggctc gtctaataaa tacatggagg tttcccgggc aaaaacagca gaccaatata
     2341 atttatgtct cattcccaga gagtaatctt ttacaaattg gtctaatgcc tcatccatac
     2401 caaattgatg tatcatcgtt gaaaagcttt caaaatgatc ctgtggaata tcaaataatg
     2461 cctgaaagaa atcagcgttc tcttttcccg ttaaataatc aaacagatac ggttccgaag
     2521 gaatatacgt tacctgtgac aggatctcct ctcttgattg acttaatcgc cccttaaaat
     2581 aaatttggga atccgtttca ataagctgcg taataattcg cagaagtgtg gtctttccgc
     2641 ttccattggc tcctctcagc catataatct ctccgggact tgcggataag tgaatatttt
     2701 ttaataaaag ccggtctttt tcgtaaccaa aattgatctc ctttatttcg aacataaggc
     2761 ttctccttta aacttctatc tcaagaataa agatactttc cataatagct gcaataaaaa
     2821 ataacaaaat aatgcaaaat aatataggaa taagttcaat tttaactaat ttatattgca
     2881 agtttttgtt tttaatactg gctgtaatga atctccaaat cataaacgga tagaggcaag
     2941 acaacaatat tgcaggtatt tcaaaaatag catgcgggag aaatgctgta ataatacttt
     3001 cacccatatt gttttgcaaa gttatctcaa tacctacacc tgcggatatg ccgcttatag
     3061 ccccaagtgc caagcttcca aagccatatg ttacaaaccc caataaaata gtcaggaaag
     3121 cttgttttgt attatgaaaa aaatagtcca tccatgtaag attgggtgat gaaataacaa
     3181 gaggattttg atagctttgg ctgatcattc cccataggaa agaggctata aaaactaaaa
     3241 taatcagaat cgatttcgtg gaatacgttt gccaataata cttaaatact cccattttca
     3301 ttttgccgtt cataaaagca atacccatcc ttatgttttt tgtccctgga agaataatag
     3361 aaaaaaaata acgcaaaacc ccacaaaacg aacaagatga agaaaatatc atagaataac
     3421 ttctgcccct gctcaaaatg gataaaagcc ccaataaaaa aaacaataca taaaccggca
     3481 ttcagcatcc ttttaggtat catgaaaaat tggtgtacaa atttcgattc gtaagtgtct
     3541 atgcgaacca taaataaatt gggatagtcg aaccgactgc aaaatttcat ccaaactgtg
     3601 cttataaacg cacttatgaa aaataataac caagaaccaa taatacccac taacaattgc
     3661 ataaaggatc catttagtaa gaaaaaacca acaattaaca ccccgtttat aatacactgt
     3721 aagggaatca acaaaatcat aatcagcctc atttttgtat tcataaattg gttaattgaa
     3781 tatttaggag atagttttat cagatcaatc tgcctcagtt cgcttgaagg gtgtaaaata
     3841 ggataactcc acagccataa ccatatagtc tgagataagg caaaccagca aataaaccaa
     3901 atggttaaaa caaagctgga gtaatcatga agactcaaca aaacaaaaga taggcccagc
     3961 aacgaactca atgcaggagg aaaaactagg gaaatgctat gcgggagttt ggtattcttg
     4021 attattcttt ccattattaa caaatcccta tttacccagg gaagattagg gaagaaaatt
     4081 ttacctaacc acctatacat acggaaaatg taatttttcg agtatgtaat aatggatatt
     4141 ctaggatttt gtacaaactg aaatcgtcta gaataattca atagataata tacaattaca
     4201 gaagcatata cagtaaccaa agttcccact acataataga accatcgtgt ttgaaagata
     4261 tgtaccaaaa aatcaaactt gtccaaaaat accgttttga cgttagagga aaaataacca
     4321 attatcgtta tgaaatcttg ttgataaacc tcaagaggaa caggtctttg aatcaacgga
     4381 agcagaaacc acctgcttag aagcgaaaca aacccaaata ttacaaccag cttaaacaaa
     4441 taaatgatgg aattctgttt tgaatctgta atagtcaaac cccatgattt caatacttct
     4501 ttttttaagt tcacataata aatagttgaa atgaataaga gccaaattaa aatcaaaagc
     4561 aatccggata taaaatcagg tgataatctt atgaggacat atatggcaat aatttcaagc
     4621 atcaattcat gaagccaaaa cataagtacc tcagataata aaataacatt taacaattca
     4681 aatctgttaa tggaagtttg ccataaacat tcgtgtatag gatgatggct tattctgttt
     4741 gcgttttgtc tggccattgt accaggaagc aggagattaa acagaagtac aataaatata
     4801 actattccct taaattgagg gtcggtaata ctttcaaata ccaatgcaaa aagtaaaaga
     4861 agcatatttt gaaacaaaag tgtggtcatc caacttaagg tagctggaag ctgatagcac
     4921 cctcctaaac atcaaatcca aaattaacta tctttaaaag gagacggccg tctcctttta
     4981 aagatagcta acaattgaat ttaccataca atagcttgtg ccttgagatt tctcttgagc
     5041 aaatctttca cattaataat agcgtaatca atcattgcac ttgtaacagc tagtccacct
     5101 gctgataaaa tcgccataat agttgatacg gctacaaatg cccaccctgc agcatcaatg
     5161 acatcaacaa tcttttttgc catcccggta ctaaaaccaa gatatcccgc aatttgaaac
     5221 aatagaatcc ctcctttcat ttgaaatgcc atactttcta ttaaatatta ctattaaata
     5281 catttttgtc aataattaca gcgaatttcc ctctatataa tataaagacc ccatagagta
     5341 tctatagggc cttttaacat catgggaagc tgccttacgg ttcacgcctc atttggctta
     5401 aatcctcttt ctccagttcc agttcattcc ggatctgttc cacaacctcc tggctgtggc
     5461 taagctcagc ctgactaacc gcgttttcgg catgcgctat tgatttatag gcttggttaa
     5521 ctgtctggtt cgtcggatgc gtcattgcct gggaaatggc attgtgtacc ttttccacgg
     5581 aattttgggc ctgggaaatc ggattttgtg attgaaggct ggagtcattt ttggccatgt
     5641 ctctgggtac ctcctcatga ttcgctatgg tccttctcag gagcacgaag ttattatgag
     5701 aaaagaaagc cttttctata cacaagaaga aaaaaatggt gcgaaatctt tatctttcgt
     5761 aaggtgaatc cgatattaaa aatgactgtt cataaatcaa acagaaacgt tattattttc
     5821 cttttctggg atgatagttt tgaacagata atcaaaataa ggagttacgt acatatgaaa
     5881 cgcatttgga tcagcatttt gttatctgga atgctcttag tttcttcgac agcggtttgg
     5941 ccgtctggaa ccgttaaggc ccagcagctg tccgaaacgc ttgccggaat gatgcaaaat
     6001 gacaccggta cagagcaatt atccgaatca aacaaacctg aacaggaagt aaaacgcctg
     6061 aaacgccaga ctgatcaaga ttatagtatg gcgtatttaa attcacttcc ctataacgag
     6121 cttgttgatc tgctcacaag ttcgagctgg acacaaattc cggaactttt taaattcaat
     6181 ccggactctc gccaatttta tgagaatcaa gaccgcttcc aggccatcat cgacgctctg
     6241 caaacaagag gaagccaatt tacggaagat gatgacaaag ggattcctac actggtagag
     6301 gtattacgct ccgggtatta tttaggctat tacaatcagg agctgggatt cctgaacacc
     6361 cgggaatata agaaaaaagt gctgcccgca ataaataaaa tgatggacaa ccgttttttt
     6421 gcatggggat ctgcaaccca gaacgaagtc atcggggcgg ccggaaaatt gatttccaac
     6481 acaactgtgg acacggaaac cgtgaatcgt atggccgggt tggtgaagga ctttgttgaa
     6541 catgtggatg attatgccgg agaccacggg aaaagcaagg cattttacga tgtcatacaa
     6601 ggaatcggtt atgtgctgtt gtgggatttg agtgaacctg acaaacaagc cattaaggga
     6661 aatattgatg cgtacttaaa cccgctattc ctgttggcaa agcagggacc ttcatctgca
     6721 gataaagtct ggttgacaaa caatgcggta tattataccg gagagctggc gcattatcac
     6781 agcaatccgg ataaggcgaa tcaggtgctc acggattcaa tgaattcgca accgcgtctt
     6841 agtgaattgt tctttattgc tgcccggcaa atttcagagc attatgcagg aaaagattat
     6901 aacggcaacc ggatcgacct gaaaaagtta aagaacgagg gaaaaacgca ttatttgccg
     6961 cagcgttttt cgtttgatga tggcaagttt attttccaaa caggcgacca gttgaaggaa
     7021 gaacagattc agcggttata ttgggcagct aaggaagtga aagcgcaatt ccaccgtgta
     7081 gtcggcaacg acaaagctct cgaaaaaggt aatgcagatg atgtgttgac cgtggtgatt
     7141 tataataacc cggatgaata ccgtatgaac aattatttat atggctatag taccgataac
     7201 gggggtattt acatagaagg aataggtaca ttcttcactt atgacagaac tgcagaacaa
     7261 agtacttaca gcctggaaga actgttccgg cacgaattta cgcactatct gcaagggcga
     7321 tatgaagtcc cgggtacttg gggcagggga cctttatatg aaagcggaac gatgccctgg
     7381 tttgaagaag gcggggccga attttttgcc ggggctaccc ggacggatag catccaaccc
     7441 cggaaatcgg tagtaggcaa tttaaggcag gatagccctt cccaacgcta ctctgtatca
     7501 cagaccctgc atgcccaata cggttcttgg aaattttatg attactcatt cgccatgttc
     7561 aatcatcttt atcaaaccga tctttctgaa cttaacaaaa ttaataatat gattcgggcc
     7621 aatgactccc acggatataa ggacaatatc gaaaaactaa gtaaagacga gaaattaaac
     7681 cgcgaattcc aacagactat tgaacagcaa atatcccagt atgacagctt gagtactcct
     7741 ctcgtttccg atgattatat ggaagtgcct cagccgaaaa acacgtcgga aatctatgcg
     7801 gaaatcgcga atgcggccgg cttgtctaac gtcaagaccg aggagcatga gtcccagttt
     7861 ttcaaaacgt tcaccctgca gggtatctat acgggaggac cgtcaaaagg aaaagtacag
     7921 gactggaaaa cgatgaacgg gttggcggac ggattcctaa aaagcttgtc cggcctaacc
     7981 tggaacggat acaataccgt aaccgcttat tttacaaact atcgcgtaac agaggacggc
     8041 cgttttgctt acgacgtcgt cttccatggt aagttaccgg aaaaagaaaa ccctggcgct
     8101 ggcggaaacc cggataacgg ccatagtgga aaccctaata cggataacga acataatgga
     8161 aacctttcgg gggaccagga accaaacaat acgttcaagc aggcaagcca attaaaattg
     8221 aaacaaacgg tttccggaac cgtgggaggt tcggactatg cggatattta ccgttttgaa
     8281 gtgaagcacc cggggcaatt ggacatactt ttggaggcgg ataaggagca aggagtggcc
     8341 tggcttttgt atcatgagtc agacttacaa aattacacgg cctacccgga taaggtggaa
     8401 ggaaagcgtc tgtcgggatc tcatgaggcc aaggctggta cttattattt atatgtttat
     8461 agtacctcgg atgaaaacca tgcgtaccag gtgtctgtta acccgacggg agagacacct
     8521 tcaattgagg aaaacgagcc taacgataca gccgataaag ctaatacatt cccaataggc
     8581 caatccgtca acggcaaact ggatggaaat gaccgtcagg atgtatttac gtttgacatt
     8641 catgatcaat cgcctatccg agttgaaatg caaaaacttc ttggggagaa tgccagctgg
     8701 atgctgttta aagaagatga tatggatcat ccggtctcct acccgacaga ggtatcagga
     8761 cttaaaatgg caggagggta tgatgccggt ccgggacggt attacctttt tgtttacaag
     8821 tatgcggatg aagatattca atacaatgtg caaattgaac cagtaaatcc gtaatttttt
     8881 cctttataga gttgtcacca taagatttga tttatggtga caactctttt tctatatgtc
     8941 gatagaacta aaataaatcc agttgtcttg gagcaagatc ttgataatca atgtccagta
     9001 agttaatgag ctgtttcgcg ttggctgccg catccccgcc tgaattattg ttgaaaataa
     9061 cggctatctc gcggacagat tgttcaagaa tacgcagccg ctccgcccat tccttcaatt
     9121 cttgttcatt ataccggtat aagtatctga cttcccgcca gttttcattt ccgctctggt
     9181 tccacccccg tacattccgg ccatggagac ggaccaaggt cagcttctcg tccgtcggaa
     9241 cagccactgt cggaatcgaa ccttctccgg cctgcggttc atcacaaatg ctgtggatcc
     9301 actgctcccg cttcataaaa gcaagcgtct tctccctcat ttccggtaca aaccagctct
     9361 gatgccgaaa ttccagggcc accggaacgt ctttcatccg ttcccgtgtc tccctaagaa
     9421 tatctacatt ttccttgata caggtgaacc agggcggata ttgaaacagc actgccttaa
     9481 gctttcccgc ctcacgcatg ggccggaggg attccaaata agcatcaaac atctccttgg
     9541 tatccgtaaa agggttcttg ccccgcaaat gtccggtcat tccttggtag gctttgcaaa
     9601 taaaagagaa ggaatccggt gcctgttccg tccatttgct catattgtga agggattgaa
     9661 ccgcataaaa gcagctgtcc acctctacaa tagggaaatg cccgcagtac ataggaagcc
     9721 tatccttgga tttaggagtc ccttcatata aatcttcatg gtcccccatc cggtaagccc
     9781 gatttgaatc atgcttctac ctcaagacct tgacccggtt tcagatgaac tccgttcagg
     9841 cggaatttct tcagactttc cacccactca tctccatcct gacgaatagg cgggaacgta
     9901 ttgaaatgca tggggatata ggtttttgct ctcagccagg tagcagctac cagtgcttct
     9961 tgcggcccca tcgtaaacac atcgccgatt ggcaaggcaa ccgcatctat ccggttcgta
    10021 tctccaatca gcttgatatc tccaaacaaa gccgtatcac cggcatgata aaaggtaacg
    10081 ccttccatag taagcaaaat tccggctggg tgccccccat ccaggaattt cccctgctcc
    10141 agctcaaagc tggatgtatg gaaagccagt gtaaatttga cttcgccaaa atcgaattta
    10201 taggacccgc caaggttcat gc
//
