LOCUS       NZ_CP020557            21684 bp    DNA     circular CON 24-JUL-2024
DEFINITION  Paenibacillus larvae subsp. pulvifaciens strain SAG 10367
            chromosome, complete genome.
ACCESSION   NZ_CP020557
VERSION     NZ_CP020557.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus larvae subsp. pulvifaciens
  ORGANISM  Paenibacillus larvae subsp. pulvifaciens
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 4666454)
  AUTHORS   Dingman,D.W.
  TITLE     Paenibacillus larvae genome sequencing
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4666454)
  AUTHORS   Dingman,D.W.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-MAR-2017) Entomology, CT Agric Expt Station, 123
            Huntington St, New Haven, CT 06504, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: FEB-2016
            Assembly Method :: SMRT Pipe HGAP assembly v. February-2016
            Assembly Name                     :: sag10367-hgap-022916
            Genome Coverage                   :: 214.2x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002082155.1-RS_2024_07_24
            Annotation Date                   :: 07/24/2024 02:27:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,275
            CDSs (total)                      :: 5,166
            Genes (coding)                    :: 4,634
            CDSs (with protein)               :: 4,634
            Genes (RNA)                       :: 109
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 532
            CDSs (without protein)            :: 532
            Pseudo Genes (ambiguous residues) :: 0 of 532
            Pseudo Genes (frameshifted)       :: 400 of 532
            Pseudo Genes (incomplete)         :: 184 of 532
            Pseudo Genes (internal stop)      :: 26 of 532
            Pseudo Genes (multiple problems)  :: 72 of 532
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:07:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1917507
            Orig. end                         :: 1939191
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP020557.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Dr. Adriana Alippi,
            CIDEFI-CIC, Facultad de Ciencias Agrarias y Forestales, Universidad
            Nacional de La Plata, 1900 La Plata, Argentina.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21684
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="9"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21684
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21684
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11684](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11684
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     gene            complement(277..933)
                     /locus_tag="B7C51_RS10195"
                     /old_locus_tag="B7C51_10195"
     CDS             complement(277..933)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0046677 - response to antibiotic [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156: Chloramphenicol acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009673388.1"
                     /locus_tag="B7C51_RS10195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_10195"
                     /product="CatB-related O-acetyltransferase"
                     /protein_id="WP_083039907.1"
                     /transl_table=11
                     /translation="MNKNKFKHWSEIKYLKDIVMNPLIEVGDYSYYSGYYDNYSFEDGC
                     VRYLWGDEKSRSLFNPIEEFGWQIDRLIIGNYVCIAGGVVILMGGNNNHHAEWITVYPF
                     VEQISHSFEPKGDTIIESDAWIGMNAMIMPGVTIGEGAIVAAGSVVTKDVAPYTIVGGN
                     PAKEVKKRFSEEEIAKLKEIRWFDWKRESIEAATHLLSSSSIDELYEYYLREIKD"
     misc_feature    complement(952..968)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 23.54"
                     /tool="antismash"
     misc_feature    complement(1078..1091)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.49"
                     /tool="antismash"
     gene            complement(1435..1563)
                     /locus_tag="B7C51_RS28435"
     CDS             complement(1435..1563)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS28435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_257789028.1"
                     /transl_table=11
                     /translation="MKKKSLRSLSKGIGTLLLFSLMLLITGEVCPNLDASGFYPFD"
     gene            1689..2451
                     /locus_tag="B7C51_RS10200"
                     /old_locus_tag="B7C51_10200"
                     /pseudo=""
     CDS             1689..2451
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611877.1"
                     /locus_tag="B7C51_RS10200"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_10200"
                     /product="IS5 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKRRYELRDDQWDQIKDMLPPERKTQGGRPAKDNRQMLNAMLWVI
                     RSGAPWRDLPEYYGPWQSVYTRFRRWEKAGVFDRMLDVLSADPDDESVMLDASIIRVHQ
                     HGRGQKGAAIPRHRPVARRLNLQNPRGSGRPRQSFQIRSDGRKHQRLRSRIRNSANP"
     gene            complement(2670..2921)
                     /locus_tag="B7C51_RS10210"
                     /old_locus_tag="B7C51_10210"
     CDS             complement(2670..2921)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000660072.1"
                     /locus_tag="B7C51_RS10210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_10210"
                     /product="DUF4318 domain-containing protein"
                     /protein_id="WP_077996229.1"
                     /transl_table=11
                     /translation="MKIRKRSLKRFFKKGFFIELDEALTYPSVQTTCEAIEKYAAESGQ
                     EVEFVSKGQPVTFYLAGKIYYVEISMARGGYYLFCREV"
     misc_feature    complement(2879..2892)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.67"
                     /tool="antismash"
     gene            complement(2955..3080)
                     /locus_tag="B7C51_RS28970"
                     /old_locus_tag="B7C51_10215"
     CDS             complement(2955..3080)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013933.4"
                     /locus_tag="B7C51_RS28970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_10215"
                     /product="LysE family transporter"
                     /protein_id="WP_077996230.1"
                     /transl_table=11
                     /translation="MAACFNIMKLTGAAYLLWLGWQGIRSKASERFKMKRMSSKK"
     gene            3307..5391
                     /locus_tag="B7C51_RS10220"
                     /old_locus_tag="B7C51_10220"
     CDS             3307..5391
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020498.4"
                     /locus_tag="B7C51_RS10220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_10220"
                     /product="glycoside hydrolase domain-containing protein"
                     /protein_id="WP_083039908.1"
                     /transl_table=11
                     /translation="MTSKACDANPLDTGSTGNKVKLLQYGLYCKGYNPRSTDGVFNQHT
                     QNALKSIQQDAGLSENQISTAAKGLQMKAVLGPDEYKKVSRGDSKIREMQQELNRRYFD
                     YTGLRPCDGIYSRGTNAALIFALQAEEHLPIGVANGNFGVTTRKCCPEIPYTQAQKDYK
                     GAVYNSESITRFIKLVQFTLYCVGHERYSALPFNGSKYDPGEFNGVFNDSTRKALQKFQ
                     KDIALPVRDRIGIDEWMALLVSTGNPDRAGDVCDCASRITPDVAAQLKKAGYTLVGRYL
                     TGDIVVKNTRVAKNLLRSEMWDIFKAELRLFVIFQDARQYYTENPHEENIVNYFTQARG
                     YADAEKAFSAAKSLGVPRNEIIYFTVDYDFMEDQVKSKIIPYFKGVNEYAKEAKNIFKI
                     GIYGSRNTCSLVKKEGYSVSSFVSDLSTGYSGNMGFPLPDDWAFDQIKEYGPSSSVSIG
                     IDKNVRSGRYEGFNDFIKEEQDNEWDLIRKNGSAYVLTDGPKGPYPDESKLPVYWAKVK
                     RADGKFEAKYPMFDGIPVGAFYSRRDINSNRDDSKGGQIRYVYFRDVGGRLNAGYIDES
                     SLINYPNEEKGKFVYHYFGGTEVWRNENGKGAFVRPLDAVDVDMKVHFLVTSTLKCYKK
                     NSIRADDLLPGTKIEIFASTSTGREYPHWIQCTAKMIPGSNTWESLIPGEPYGVCRFGI
                     "
     gene            complement(5504..6364)
                     /locus_tag="B7C51_RS10225"
                     /old_locus_tag="B7C51_10225"
     CDS             complement(5504..6364)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS10225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B7C51_10225"
                     /product="hypothetical protein"
                     /protein_id="WP_158530352.1"
                     /transl_table=11
                     /translation="MMMKKGTGIVLLLLVSLLFLGGCTSQEEYDESGRKEDTFIPLKRP
                     NMFTLNFHDLFGQISAKIKAEDNKVADPTMDILFTPGGEIMHVDCSVHALMESSDSEDQ
                     YTMRLYRIRNNHETEFNNKQSLPEAFSAPSSTMTGIDVYRESGGYYDGRDMDMLNFQKF
                     PKFIEWFANFNLKSVLEQYTVGRPVRFQLLSGPITGEVVKNPDVHVTYLDCSPNDIREM
                     DKPKSYPVSRYLEFTDKDYYAVIPYYVQDGTIKGFNEMKLGQTEKITYIANNVILLIVD
                     KTTKG"
     misc_feature    complement(6431..6440)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     misc_feature    6484..6502
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 24.82"
                     /tool="antismash"
     gene            complement(6852..7643)
                     /locus_tag="B7C51_RS26635"
     CDS             complement(6852..7643)
                     /GO_function="GO:0004833 - tryptophan 2,3-dioxygenase
                     activity [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /GO_process="GO:0019441 - tryptophan catabolic process to
                     kynurenine [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014969209.1"
                     /locus_tag="B7C51_RS26635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tryptophan 2,3-dioxygenase"
                     /protein_id="WP_237089147.1"
                     /transl_table=11
                     /translation="MRHSMTYGDYLYLDRLLSSQHQLSGHHDEMLFIIIHQASELWMKL
                     MLHEINAVISYIQSNHLQKAFKILTRVSKIQEQLIQSWNVLVTLTPAEYMEFRNQLGQS
                     SGFQSYQYRLIEFALGIKNTQKLAIFEHQSELYQQLAKAAHAPSLYDAAIQALAVAGLS
                     IDSDMLDRDFSKKFQPNASVEQAWLTVYKQTEQYWELYELAEKLMDIASQHQFWQAKHM
                     GTVERIIGSKVGTGGTSGVSYLKKVLEQNLFPELWNLRTKM"
     gene            complement(<7752..8360)
                     /gene="kynB"
                     /locus_tag="B7C51_RS26640"
                     /pseudo=""
     CDS             complement(<7752..8360)
                     /GO_function="GO:0004061 - arylformamidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019441 - tryptophan catabolic process to
                     kynurenine [Evidence IEA]"
                     /codon_start=1
                     /gene="kynB"
                     /inference="COORDINATES: protein motif:HMM:TIGR03035.1"
                     /locus_tag="B7C51_RS26640"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="arylformamidase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGEWIDISQPLNEKVVVWPGDTVFSYKVKWRKAESGSVNVGKITM
                     SVHTGTHIDAPFHFDDAGKRVKDFDLDVFIGQARVIRIPNKSVIGIKELSSFDLDGETR
                     LLIRTDAWPDRTVFPVSIPYMDLQTIGYLSDKGIRLIGFDLPSVDPIESKTLLVHHQLS
                     HADISILEGLVLDHIDAGDYEFIALPLSLSEADASPTRAV"
     gene            complement(<8937..>9512)
                     /locus_tag="B7C51_RS25835"
                     /pseudo=""
     CDS             complement(<8937..9512)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014097094.1"
                     /locus_tag="B7C51_RS25835"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus and C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKGTYRQLLIIT"
     misc_feature    complement(9936..9951)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     gene            10001..10150
                     /gene="scfA"
                     /locus_tag="B7C51_RS10245"
                     /old_locus_tag="B7C51_10245"
     CDS             10001..10150
                     /codon_start=1
                     /gene="scfA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016113838.1"
                     /locus_tag="B7C51_RS10245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_10245"
                     /product="six-cysteine ranthipeptide SCIFF"
                     /protein_id="WP_077585121.1"
                     /sec_met_domain="TIGR03973 (E-value: 4.1e-23, bitscore:
                     79.2, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 1.4e-22, bitscore: 77.5,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRIVTLSTRKLTDTIKYGGCGACQTSCQSACKTSCGVANQKCEN
                     IMNR"
     aSDomain        10278..10589
                     /aSDomain="Ranthipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a
                     ranthipeptide/SCIFF cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_B7C51_RS10250_Ranthipeptide_rSAM_RRE.
                     1"
                     /evalue="2.20E-34"
                     /identifier="RREFam024.1"
                     /label="B7C51_RS10250"
                     /locus_tag="B7C51_RS10250"
                     /protein_end="104"
                     /protein_start="0"
                     /score="108.6"
                     /tool="antismash"
                     /translation="MIHQYKLNGYNIVLDTYSGSVHVVDDLAYEIIALYETTRVEEIVS
                     IMLEKYVHDSNISEKDIRETIADIEELKNDGELFTEDEYKNLSMDLKNRQTYVKALCLN
                     "
     gene            10278..11684
                     /gene="scfB"
                     /locus_tag="B7C51_RS10250"
                     /old_locus_tag="B7C51_10250"
     CDS             10278..11684
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="scfB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006093990.1"
                     /locus_tag="B7C51_RS10250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_10250"
                     /product="thioether cross-link-forming SCIFF peptide
                     maturase"
                     /protein_id="WP_083039914.1"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 3.9e-32,
                     bitscore: 108.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 2.9e-70, bitscore:
                     235.4, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 4.7e-12, bitscore: 44.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 5.6e-18, bitscore:
                     63.3, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHQYKLNGYNIVLDTYSGSVHVVDDLAYEIIALYETTRVEEIVS
                     IMLEKYVHDSNISEKDIRETIADIEELKNDGELFTEDEYKNLSMDLKNRQTYVKALCLN
                     VAHTCNLSCEYCFASQGKYNGSRAIMSYEVGKRAIDYLLENSGHHRNLDVDFFGGEPLM
                     AWKVVKQIVAYARSKEKEYKKTFRFTFTTNGMLLNDEVTDFLNKEMYNVVLSLDGRKQV
                     HDHLCKTVTGKGSYDYIVPKFQEFVEKRGDKEYYVRGTYTRNNVDFTNDIFHIADLGFD
                     KISMEPVICDPREPYALTAENLPDLYNQYEILAKEMLKREEEGNGFTFYHYMLDLSEGP
                     CIQKRISGCGSGTEYLAVTPWGELFPCHQFIGDNEYRIGNIWDGITRQETQCQFKESNC
                     YSKPKCQDCWAKLYCSGGCPANALHSTGSINGIYDFSCDIFRKRVECSMMVKVAESMRA
                     MNKNVQAAAQ"
     gene            complement(12294..12917)
                     /locus_tag="B7C51_RS10260"
                     /old_locus_tag="B7C51_10260"
     CDS             complement(12294..12917)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS10260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B7C51_10260"
                     /product="hypothetical protein"
                     /protein_id="WP_083039916.1"
                     /transl_table=11
                     /translation="MLPCRSSEVRDKLIQEYDIKPIAHVRLLNGQERRSCTKDLLTNSY
                     YCFSYRAKNGDVTGTFLCGTYAANHFLELIHHPKLTLFDPLASEAIGMVTNSINGKAGF
                     NETWHPAAKQLFNAINLLIICWGIAPGSVLQEIKNDLEKYKSREPLPRQIKAINTIISR
                     DKGGRTLQQMLDELRNKNNKIRNFCFDLLNEALIKNKIEKSFFG"
     gene            complement(13097..13705)
                     /locus_tag="B7C51_RS10265"
                     /old_locus_tag="B7C51_10265"
     CDS             complement(13097..13705)
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013213.4"
                     /locus_tag="B7C51_RS10265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_10265"
                     /product="TatD family hydrolase"
                     /protein_id="WP_083039918.1"
                     /transl_table=11
                     /translation="MIDVHCHIDLYKNPYVVANENEKKGISTIAVTNLPSYFELGYSHL
                     KKFKYIRVALGLHPLHANKHTPTEMKRFIDFAKTTSYIGEIGLDFSREGITTKTKQIQS
                     FRHVLSHISDRPRFITLHSRRAESIVLQMLEEFSIKGAVFHWYSGSLSLLKEIVEAGHY
                     FSINPAMIQSSNGCKMIEKIPQDRLLTETDGPFVKMKAR"
     gene            complement(13720..>14634)
                     /locus_tag="B7C51_RS10270"
                     /old_locus_tag="B7C51_10270"
                     /pseudo=""
     CDS             complement(13720..>14634)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013540.4"
                     /locus_tag="B7C51_RS10270"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_10270"
                     /product="helix-turn-helix domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="AIGISEGNLSEIEMGNSNPSAETLASIGIHYNVNLNWLLIGENSG
                     DGVTYEDDNDKRLIDLQVRAGQNPSGKETTFRSRSILFLAIGIYAAASIGEDIPLLIPE
                     NGTIALNIPLTPSRRGTCSTRTAHPNYLRMLSHIIQSVRICNPILNPLGMKTKGEAISQ
                     CKNQQVLQNAIPDSVSCGKSGHKSSWIRRDAKGCGRCVPCIFRRASLHVINADTEIYGI
                     DICSDEIDLTGNKASVNDLRAVLAFLGHNYNIEEIKRLLLSSGVPIEEIDEYSSLVIRA
                     MAEVKELIDDKGTTGIKRLIGLT"
     misc_feature    complement(14636..14650)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.65"
                     /tool="antismash"
     gene            complement(14855..16681)
                     /gene="glmS"
                     /locus_tag="B7C51_RS10275"
                     /old_locus_tag="B7C51_10275"
     CDS             complement(14855..16681)
                     /EC_number="2.6.1.16"
                     /GO_function="GO:0004360 - glutamine-fructose-6-phosphate
                     transaminase (isomerizing) activity [Evidence IEA]"
                     /GO_process="GO:1901137 - carbohydrate derivative
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="glmS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014372544.1"
                     /locus_tag="B7C51_RS10275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_10275"
                     /product="glutamine--fructose-6-phosphate transaminase
                     (isomerizing)"
                     /protein_id="WP_077996250.1"
                     /sec_met_domain="GATase_7 (E-value: 2e-17, bitscore: 61.5,
                     seeds: 307, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCGIVGYIGNRNSREVLINGLSKLEYRGYDSAGIAVQTKQGLQVK
                     KAKGRLAILESKLNEEPVQGSVGIGHTRWATHGKPSDVNSHPHTDDSSKFAVVHNGIIE
                     NYIALKEELIAKGHHFASETDTEVIAHLISELYDGDIVKAVQQAVKQIRGAFALGVLTE
                     YEPDKLVAVRLASPLIIGVGEGENFIGSDIPAILEYTRNVYILNDGEMAVLTRDGVELR
                     TIEGNFISREMFHVDWDLITAEKAGYEHFMLKEIYDQPKAYRDTMGSRIADGDKINLEQ
                     VSMSKEDIKNIDRIHIVACGTAYHAGLVGKYVIENLARIPVEVDVASEYRYRTPIITDK
                     TLVIGVSQSGETADTLAALREAKRCGARILAITNVVGSSVAREADDLILTWAGPEIAVA
                     STKAYTTMLISFYLLGLHLAQQLGTKDEAYIKNVIAAMKSLPEQVESILNRTDEIKKFA
                     EEIAGYEDLFFIGRGLDYAVALEGSLKLKEISYIHSEAYAAGELKHGTLALIEEGVPVI
                     ALATQADLFEKTVSNIKEVTARGAHVLGLSHEGDAELKKSVDQHFVIPQTLDLLSPALS
                     VVPLQLLSYYASLARGNDVDKPRNLAKSVTVE"
     misc_feature    complement(16871..16885)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     strong, score: 24.83"
                     /tool="antismash"
     misc_feature    complement(17179..17188)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     misc_feature    17240..17253
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.35"
                     /tool="antismash"
     gene            complement(17647..18986)
                     /gene="glmM"
                     /locus_tag="B7C51_RS10285"
                     /old_locus_tag="B7C51_10285"
                     /pseudo=""
     CDS             complement(17647..18986)
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008966 - phosphoglucosamine mutase
                     activity [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="glmM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016818744.1"
                     /locus_tag="B7C51_RS10285"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_10285"
                     /product="phosphoglucosamine mutase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGKYFGTDGVRGIANRELTPELAYKIGRCGGYVLTGKAEHPKVII
                     GRDTRISGPMLEAALVAGLLSIGANVIRVGVVSTPAVAYLTRTLDADAGVMISASHNPV
                     EDNGIKFFGETVLSCWTRRSLRLSACLMPRPMNCLDRLAEISDRCWTMKNSNSSMRNF"
     gene            complement(19011..19484)
                     /locus_tag="B7C51_RS10290"
                     /old_locus_tag="B7C51_10290"
     CDS             complement(19011..19484)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019561.4"
                     /locus_tag="B7C51_RS10290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_10290"
                     /product="YbbR-like domain-containing protein"
                     /protein_id="WP_083039922.1"
                     /transl_table=11
                     /translation="MTVYSNSPNDLDKMEFYEGPEVNLADLKETKKFTLDIPHRNNVTQ
                     TDPDKVDVTVEIVPSVTKQVENFPLNITGLAKNMNAKITTPESGQISFTMEGAQTLLNE
                     VKLEDIQAAIDVTNLPPGDHEVTVNINLPPYIKNATGEIKATVTITEKKKRAK"
     gene            complement(19481..20242)
                     /locus_tag="B7C51_RS10295"
                     /old_locus_tag="B7C51_10295"
     CDS             complement(19481..20242)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019561.4"
                     /locus_tag="B7C51_RS10295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_10295"
                     /product="YbbR-like domain-containing protein"
                     /protein_id="WP_083039924.1"
                     /transl_table=11
                     /translation="MDKWLRNPNVVKIVALMLGIMLWVVVRMDGNTGNISSVGLKEQTI
                     SNVAVVPKYDSSQYYVSSIEPSEVTIRLKGRQFAIDKVSTSNYKIELDLTKASAGEYYL
                     APMAVGLPSSLDWEIYPRTVKVAIEKQQKKEVPVVIDVTGTPKEGFKAGQPIVKPNRVH
                     VTVPDSKADLVDSVHGEISVDQADSTIKQQVKLRAFDKKGKELDFEVSPAVVDVEVPVT
                     MPFKAMPLQIKLVGDPRRDLRLPLSSRVPIK"
     gene            complement(20235..21049)
                     /gene="cdaA"
                     /locus_tag="B7C51_RS10300"
                     /old_locus_tag="B7C51_10300"
                     /pseudo=""
     CDS             complement(20235..21049)
                     /GO_function="GO:0004016 - adenylate cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006171 - cAMP biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cdaA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009675030.1"
                     /locus_tag="B7C51_RS10300"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_10300"
                     /product="diadenylate cyclase CdaA"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEYFAVFSFNDIVDILIVSYVIYKLIMLIRGTRAIQLMKGIFIVV
                     ATWAFSFLFKLNTLQWMMNQMFNIGLLPSS"
ORIGIN
        1 gtccggaagc tggcatgaat gaggaatatc cttatttaca ggaagtttta agtagaccga
       61 ttaactggga tctcatccgt caacagtatg aacaaatcat taagtatgca acggtacggt
      121 tgggaactgc atcagcagaa gcgattttaa agagatttac cagagatgat tcattgtttg
      181 tagttgttct tcagtcatct tggtaagtat cttaggatta ccgtaatatt aaaaagctag
      241 gcagaatatt ctgcctagct ttatatttat aggaactcag tccttaattt ctcgtaaata
      301 gtactcatat aactcatcaa tagaagaact tgaaagtaag tgagtggctg cttcaataga
      361 ctccctcttc caatcaaacc agcgtatctc ttttaacttc gcaatttcct cttctgaaaa
      421 acgcttcttt acttcttttg cagggttccc gccaactata gtgtaaggtg caacatcttt
      481 tgttacaact gaacctgctg caacaattgc gccttcacca atggtaacac ctggcataat
      541 cattgcattc atgccaatcc atgcatcact ttctatgatt gtgtcccctt ttggttcaaa
      601 ggaatggcta atttgttcaa caaacggata aacagtaatc cactctgcat ggtgattgtt
      661 atttcccccc atcagaatga cgacaccgcc tgcgatacat acataattac caataattaa
      721 tcggtctatt tgccatccaa attcctcgat tgggttgaat aagctcctag atttttcatc
      781 tccccataaa tacctcacgc atccgtcttc aaaggaataa ttatcataat aaccggagta
      841 ataggagtaa tcaccgactt cgattaatgg attcattacg atatccttta aatatttaat
      901 ctcagaccag tgtttaaatt tgtttttatt cattttgata tcctcgcttc taagttattt
      961 tcttacaatg gttacttaga agctaaatgc ggtagctaca ttcttaagca tttttagacg
     1021 gcgaaccatc ggaatcatcc ttccttaata tatgatggga attatagcaa tgacttattt
     1081 ttttgtcaaa ttcactcact aaacaacatt agggttagaa gacaaaaaaa gggatacaaa
     1141 atatatttag ttaattttca aatcgttgtt tacattcatg atatcgatac tccacaatcc
     1201 ggtgaacagc tgaaagaaat ctttattttt catttcaagt tttaaaagcg actggtatcc
     1261 gtttcctccg ccggtttgac ataaatgttt tggcccatta atttcatctt gtccctctcc
     1321 tttttaacaa aataaaaaac accacagatc tcctgtagtg tacatgtcaa cctatatgca
     1381 accacaggaa aagcgaccta tggtattttt ccactgtatc cttgcaatac cgttctaatc
     1441 aaaaggataa aagccgctcg catccaaatt tggacatact tctcccgtga ttagcagcat
     1501 caaagaaaac agcaatagag ttccgatacc tttagataaa gaccttaaag attttttctt
     1561 cattggaata ccctccttcc cctgttttct aaaattatcc gaaacatttt aacgcataaa
     1621 tgattgagtt tagactaggg tgcgttttca aagtatcatg aagtccaaaa gtctggtaaa
     1681 ctttgcatat gaagagacga tacgaattac gagatgatca atgggaccaa atcaaagata
     1741 tgttgccgcc tgaacgaaaa acgcagggtg gccgccctgc caaggataac cgtcaaatgc
     1801 tcaatgcgat gctttgggtg atccgttcgg gagcgccttg gcgcgatttg cccgaatact
     1861 acggaccttg gcaatcggta tacacccgat tccgccgatg ggaaaaagca ggcgtattcg
     1921 atcgcatgct ggatgtcctt tctgccgatc ccgatgatga aagcgtcatg ctcgatgcct
     1981 ccattatccg tgttcaccag cacgggcggg ggcaaaaggg ggcagcaatt ccaaggcatc
     2041 ggccggtcgc gaggaggctt aacctccaaa atccacgcgg tagtggacgc cctcggcaat
     2101 cctttcaaat tcgaagtgac ggcaggaaac atcaacgatt gcgtagtcgg atacgaaatt
     2161 ctgcaaaccc ttgatatcga aggtaaaaac gtcttggctg atcgtgggta cgacaccgat
     2221 aaaattattg cgctgctgga agaaaaacag gcctgttccg tcattcccag ccgtaaacat
     2281 cgaactgttc aacgcgcaac cgactggtgg ctctttaaag aacggcacct ggtcgaatgt
     2341 cttttcaata aactgaaaca caatcgtcga ttagctactc gttacgataa attatcgtgc
     2401 acgtttgttg cttttttaaa gctggcttct gctatgatct ggctggctta aggtttgaaa
     2461 acaaacccta gatcatctca taaaaattgt caactaaagc gtgtttttcg ttttccgatg
     2521 caagaaacaa tatattttat tcgtagacca tcacccaata tctttctccc ggttctcctt
     2581 cttcaacaac tttcttccaa ccgttattct cataaaatta ggccagttgc tcattacatg
     2641 tccaaaagtt atatacttgt ctgtttcatt tacacttccc tgcaaaatag atagtatcct
     2701 ccgcgggcca tacttatttc aacgtaataa attttacctg ctaaatagaa cgtaaccggc
     2761 tgtcctttac ttacaaactc aacctcctgt ccggactcgg cagcgtattt ttctatagct
     2821 tcgcaagtgg tttgaacaga cggataggtc agtgcttcat ccaattcaat aaaaaatcct
     2881 tttttaaaaa atctttttaa agatctcttt cttattttca ccgtcaatcc ctttcctttc
     2941 cattcctaat attcttattt tttcgaactc attcttttca tcttgaaccg ttcagatgct
     3001 ttcgaacgaa tgccttgcca gcctaaccat aataaataag ctgcaccagt aagtttcatg
     3061 atgttaaaac aagcggccat tttgccaata acttattttt cttgtcaatg caacaagaaa
     3121 agaggtcttc tccctgttaa caaagtagct cagatttttg tacttgtgct attcaatatc
     3181 cggctccaaa attattattt ttaattaata ttgacgggct accccggaac agcaacttcg
     3241 aaagcattaa tatccgcttt acaaattgaa ctggggcttt cttccgtcac aggaaacttt
     3301 ggaaatatga cttccaaggc ctgcgatgca aacccgctgg ataccggaag tacgggaaac
     3361 aaagtcaaat tacttcaata tgggctttat tgtaaagggt ataatccgcg aagtacggat
     3421 ggggtattta atcaacatac acaaaacgcg ttgaaatcca ttcaacagga cgcgggatta
     3481 tcggaaaacc aaatctcaac agctgcaaaa ggacttcaaa tgaaggcggt tctcggccct
     3541 gatgaataca agaaagtcag ccgcggagac agtaagatac gggaaatgca gcaggaactg
     3601 aaccgcaggt atttcgacta tacgggtctt cgcccctgtg atgggattta ttcacgggga
     3661 acaaatgcgg cacttatctt tgctttacag gccgaagaac atttgcctat cggcgtcgca
     3721 aatggcaact ttggcgtgac aaccaggaaa tgctgtccgg aaattcctta tacgcaagca
     3781 caaaaagatt ataagggtgc ggtttacaac agcgaaagta ttacccggtt catcaagtta
     3841 gtacagttca ccttatattg tgtcgggcat gagcggtaca gcgcacttcc tttcaatgga
     3901 agcaaatatg atcccggtga gtttaacgga gtgttcaacg attccaccag aaaggctctt
     3961 caaaaattcc agaaagatat cgccctgcct gtcagggaca ggattggaat agacgagtgg
     4021 atggcactgc ttgtcagcac aggtaatcca gatcgtgccg gcgacgtttg tgactgtgct
     4081 tccagaatta cgcctgatgt cgcagcccaa ttaaaaaaag caggatatac acttgtgggt
     4141 cgatacctga ccggagatat cgttgttaaa aatacccggg tggccaaaaa cctattacgc
     4201 tcagagatgt gggatatttt caaagcggaa ctaagactct ttgttatctt ccaagatgca
     4261 aggcagtatt acacggaaaa cccgcatgag gagaacattg taaactattt tacacaagca
     4321 cggggatatg ccgatgcaga gaaagcattt tccgccgcca agtcacttgg tgttccgagg
     4381 aacgaaatta tttattttac ggtagattat gattttatgg aagatcaggt caagtcgaag
     4441 atcattcctt attttaaagg tgttaatgaa tatgcgaagg aagcaaagaa tattttcaag
     4501 atcgggattt atggttcccg caacacctgc tcacttgtga aaaaggaagg ttattctgtc
     4561 agcagtttcg tttctgacct ttcaactggg tacagcggaa atatgggttt tccccttcca
     4621 gacgattggg cctttgacca aatcaaagaa tatggcccga gttcatctgt aagcatcggt
     4681 atcgataaga atgtacgttc aggccggtat gaaggtttta atgactttat taaggaagaa
     4741 caggataatg aatgggatct aattcgtaag aacggttctg cgtatgtgct taccgacgga
     4801 ccaaagggac cctatccgga tgaaagtaaa cttccggttt attgggcaaa agtgaaaagg
     4861 gctgacggaa aattcgaagc caaatatccc atgtttgacg gcatcccagt tggtgcgttt
     4921 tatagccggc gggatataaa ctcaaatcga gatgacagta aagggggtca aattcgatat
     4981 gtatatttca gagatgtcgg cggacgactt aatgcgggtt atattgacga gtcgtctttg
     5041 ataaattatc cgaatgaaga aaagggaaag tttgtctatc attactttgg aggtacagag
     5101 gtatggagaa acgaaaatgg aaaaggtgcc tttgtgcggc cactagatgc tgtagatgta
     5161 gatatgaagg ttcacttctt ggtaacctca accttaaaat gctacaaaaa aaactccata
     5221 cgtgctgacg atcttttgcc gggaacaaaa atcgaaattt ttgcatcgac tagtacggga
     5281 agagaatacc cacactggat tcaatgcacc gccaaaatga ttcccggaag caacacgtgg
     5341 gaaagcttaa tcccgggtga accatacggg gtttgtcgat ttgggatttg aaatgggtgt
     5401 catgcctcat aatagaagcc tgattaccgg tataagcaag taaatatcga gaaagctgca
     5461 tgtagaagca ggccatgttc aaaatgcctg cttctatact cgtttatcct tttgtcgttt
     5521 tatcaacaat aagaagaatg acgttattgg ctatatacgt gattttttct gtctgcccca
     5581 atttcatttc attaaacccc tttatggttc catcctgtac ataatagggg atcacggcat
     5641 aatagtcttt atcggtaaat tccaaataac gggacaccgg gtatgatttc ggtttgtcca
     5701 tttcacgtat gtcgtttggc gagcagtcca ggtaagtaac atgcacatct ggattcttga
     5761 caacctcgcc tgtgataggc cccgatagaa gttggaagcg aacgggtctt cccaccgtat
     5821 attgttctaa tactgatttt aagttgaagt tcgcaaacca ctctatgaac ttggggaact
     5881 tttgaaagtt taacatgtcc atatctctcc cgtcatagta ccctcccgat tcccgatata
     5941 cgtcaattcc cgtcatggtt gaagaaggtg ccgagaatgc ttctggcagg gattgcttgt
     6001 tattgaattc ggtttcgtgg ttattcctga ttctatacag cctcatggtg tattgatctt
     6061 ccgaatccga cgattccatc agtgcatgaa cggaacaatc gacatgcata atttcgcctc
     6121 cgggagtaaa caggatatcc atagtcggat cagctacttt gttatcttca gccttaattt
     6181 tggcggaaat ttggccaaac aggtcatgaa agtttaaggt gaacatattg ggacgtttca
     6241 acggaataaa agtatcctct ttgcggccac tttcatcata ctcctcctgt gatgtacagc
     6301 cacccaggaa gaggagggaa accaataaca gtaaaacgat tcctgtacct tttttcatca
     6361 tcatcactcc aattataaaa gtttgcaata aacatagtgc ttgatgcatt atgaaatgag
     6421 gcttaagaaa taaaaaaaca tctgtacatt ccgtaagatg tgatcagtcc attgaggggg
     6481 aataacagga tacataacca gtataccgat ctttttcttg atttcccaga aatataaact
     6541 aattttggaa aataatgaac acaccccttc ctatgaaatt actcctgttt caagaaacag
     6601 gcttgcctga tttgccgatt tattggtttt gtgattcaaa aaaccaattt cctcaaactt
     6661 ctcaatttgc tgtcatgccg cataatagaa gcctgattac cggtataagc aagtaaatat
     6721 cgagtaaagc tgtatgcgga agcaggccat tttgaatatg acctgcttct gtactcattt
     6781 attcttttgt cgctttgtcg acaataagaa gaatcacgtt gttggctata tacgttaagc
     6841 cggctgactg tttacatttt tgttcgaagg ttccacagtt cggggaatag gttttgctcc
     6901 agtacctttt ttaaataaga tactcctgaa gttccgccgg tccctacttt gctcccaata
     6961 attcgttcga cggtccccat atgcttcgct tgccaaaact gatgttggct cgcgatatcc
     7021 attagctttt cagctaattc gtagagttcc cagtactgtt ctgtctgttt gtacaccgtt
     7081 aaccaagctt gctctacact tgcattcggt tgaaactttt tcgaaaaatc ccgatccagc
     7141 atatcggaat caatggacaa tcccgctaca gccaaggctt gaatggctgc atcataaaga
     7201 ctgggtgcat gtgcggcttt tgctaattgt tggtacaatt ccgactgatg ctcaaatatc
     7261 gccaactttt gagtattttt aattcctagt gcaaattcaa tcaaacgata ctgatacgat
     7321 tgaaacccgg atgattgccc taattgattt ctgaattcca tatattctgc tggggttaat
     7381 gttacgagca cgttccatga ctgaattaat tgctcttgta ttttagatac ccgggttaag
     7441 attttaaacg ctttttgcaa atggttactt tggatatagg aaatgaccgc attaatttca
     7501 tgcagcatta acttcatcca cagttcactc gcttgatgga taattataaa caacatttca
     7561 tcatgatgtc cggagagttg atgttggcta gagaggagcc gatccaaata taaatagtct
     7621 ccatacgtca tcgaatgtct catttctgct ggttgattcg ttagatgtgt ttcatctaac
     7681 ttctcaattg tattgtttgt ggctgtcatt ttggtttgct cccctttctt tactttaggt
     7741 aattttttta agacagcacg agtcggactt gcatcggcct cacttagaga aagggggagg
     7801 gcaatgaact cataatcacc ggcatcaatg tgatccaata ctagcccctc taaaatcgag
     7861 atatccgcat gtgataattg atgatggacg agaagagttt tgctttcaat cggatctaca
     7921 gatggaagat caaatccgat gagacggata cctttgtccg acaagtagcc gattgtctga
     7981 agatccatgt aagggataga aaccggaaat acggttcggt ctggccaagc gtctgtccga
     8041 attaagagcc gcgtttcgcc atcgaggtcg aaactggaca attccttaat gccgattacg
     8101 gatttattgg gaattcgaat gacacgcgct tgccctataa acacgtcaag atcgaaatcc
     8161 ttcacacgtt ttccggcgtc gtcaaaatga aagggagcat cgatatgggt gcctgtatgt
     8221 acgctcatcg taattttgcc gacattgacg gacccacttt cggcttttct ccatttcact
     8281 ttgtaagaaa aaacggtatc tcctggccaa accacaactt tttcgttcaa tggttgtgaa
     8341 atatcaatcc attcacccat gtcgtaagct cccgtttaat tttgtagtaa agtatcaaag
     8401 ctttcgttat ttacaatgtt tgtttcgatt gcatgtagaa tgtgttggat caccgttaca
     8461 ttatgttcga taaagtcacg atcccaacag ttcatcatga gtccccatgt ctggttgtta
     8521 aactggacca gatttttttg tgcgaactcg taaccgtctc aacggttagg ttatgaatgt
     8581 tcgctctaat cagacccgca ttggttagct gatccagata cattttaaat tgattaaact
     8641 ttctttgtgc aaaaggtgtt tttcgccatt tccataaaaa tcatgccttt ttcctctgaa
     8701 ttccatgttc tgaatatggg atgttccttc cgttacagac tgtgtaggtg gtgatgcaaa
     8761 tttcctatct aaactataaa cgcaaaatca tgctaattta accccatctc taccataata
     8821 tacaagtata tacgttattg caattaattc caactatatt ctaacttagt atatttttgg
     8881 tttattgtat taacatttct cctacctatc gcaaatttga acattgcctt tcagaagtcc
     8941 agattgatga ccagaaactg aagggcgatg acggtcaaac tggattcggc gccacgaaca
     9001 cgaatgcgac ccagtcccaa tttacgcttg ccttctccaa acttgccttc gttcgcattg
     9061 cgttgtgcgg cgtcctgccg atcttgctca cgattgctcg ctttactttg ttctttcgag
     9121 ggccttcaag cttgggaccg cttaatcgaa tcccatgttc cttgcagtag ttcaggtgtc
     9181 tcggctccgg tagattttat ccgctagaat gacggcagga taataaccaa atcgctgttt
     9241 gtacgcttcc accgatgctt gcagcattgt gcttcgttga agctgtccca ttgcacggtt
     9301 tcgatccaag cataagcacc cacaagactg gcagcaagtt tggtgccgaa ctctacgttt
     9361 gctccggctt tgcctagaac catcgggcgt acatgcgact gttcgatact catcatgcga
     9421 ttggcaatga catgcgtatt cttctccacc atttcgcgct gctgacggta gagttacgta
     9481 atgatcagaa gctgacgata agtgcctttt gcttagcttt gtaaaatggt tggcaggtac
     9541 ctgactggga tatcgtcgta aagaataccc gggttgccaa aaatctgctg atttcggaaa
     9601 tgaacgatat ttttaaggct aaattaagtc tctttgttat attccaagat ggcagacaat
     9661 attacacgga aaacccggat aaagaaagat acacacgaaa ccataaaggt acacttcttg
     9721 gtaacatcaa ccatgaaatg ctacaataaa actcctactc attattcttc tgtcggcttg
     9781 tcgacaataa gaagaatcac gttgttggac cctcaagacc cttcacatca cgataaaaaa
     9841 agagctgcac aattgagtga atttccgcag caacaaaaca tcacgaaatg attgacgtga
     9901 accaaagctg ttgttaaaat tattaatgga attaatgtga aattattcac aataattgaa
     9961 cttgtttctt aaaagatatt tttaaaagga gttatttatt atgaaaagaa tcgtaacact
    10021 aagcacccgt aaactgacag atacaataaa atatggcgga tgtggtgcat gtcaaacatc
    10081 ttgccaatca gcttgcaaaa cgtcttgcgg tgttgcaaat caaaaatgcg aaaacataat
    10141 gaacagatag aaaacaagaa acgtaccgcc taactgcttt ccgcatgggc ggccattttt
    10201 atctcgcatc agcaggaagt aaaagtccta taaacggagg ttttacttta taaataaaag
    10261 gagcttgatt atcaagtatg attcatcaat ataaactaaa cggatacaac atcgtactcg
    10321 atacctacag cggatcggta catgttgtcg acgatctcgc ctatgaaatc atcgcccttt
    10381 atgagactac tcgtgtggaa gaaatcgtat ccataatgct tgaaaaatac gtacatgatt
    10441 ccaatatctc tgagaaggac attcgggaaa caattgccga tatcgaagag ctaaaaaatg
    10501 atggggaact ctttactgag gatgaatata agaatctctc aatggattta aaaaatcgcc
    10561 aaacttatgt aaaggccctc tgcctcaacg tcgcacatac atgtaacctg tcatgtgaat
    10621 actgctttgc cagccaagga aaatacaacg gaagcagagc gatcatgagc tatgaggttg
    10681 gcaaaagagc tatcgattac ctattggaaa actccggtca ccaccgaaac cttgacgttg
    10741 atttctttgg tggagaaccg ctcatggcct ggaaagttgt taaacaaatt gtcgcttacg
    10801 caagaagcaa agaaaaagag tacaaaaaaa cttttcgctt cacctttact acaaatggta
    10861 tgttattaaa cgatgaggtc accgatttct tgaataagga aatgtataat gtcgtattga
    10921 gtcttgatgg aagaaaacaa gttcacgatc acctttgtaa aacagtaacc ggaaagggaa
    10981 gctacgatta tatcgttccg aagttccagg aattcgttga aaagcgtgga gataaagaat
    11041 attatgtgcg tgggacttat acccgcaaca acgttgactt caccaatgac atttttcata
    11101 tcgcagatct gggcttcgac aaaatctcga tggaaccggt catctgtgat ccccgggaac
    11161 cctatgcgct taccgcagag aaccttccag atctatataa ccagtacgaa attctcgcca
    11221 aggaaatgct aaaacgtgag gaagaaggca atggcttcac cttctaccat tacatgcttg
    11281 acctctcaga aggcccttgc atccaaaaga gaatttccgg ctgcggttca ggaaccgaat
    11341 atctcgctgt cacaccatgg ggtgagctct tcccttgcca ccagttcatc ggggacaacg
    11401 aatacaggat aggaaacatc tgggatggga ttacaagaca agagacgcaa tgtcaattta
    11461 aagagagcaa ctgctactcg aagccgaaat gccaagattg ctgggcaaaa ctttactgca
    11521 gtggcggttg ccctgctaac gcacttcact caacagggtc catcaatgga atctacgatt
    11581 tcagttgtga catcttccgc aagagggtag aatgttccat gatggtgaaa gtggccgaat
    11641 ccatgagagc tatgaataaa aacgtacaag ccgcagctca ataaacacaa agagattata
    11701 agaggctgag acataagtcg aaaatttgat ttgaactgaa ccccgaatag tggacacttt
    11761 aaaaaaagtg gacctattcg gggttcggtt cacccttaat aatccgattg ttttatttcc
    11821 gccaaaaagt tgaacagtct gccttatcca aaatattaat tttgctctta aagatgcagc
    11881 aattacctac cgatagattt gatagatggt attaaatttt attgtcgccg aaattcctat
    11941 tcctcggcct tgtttaatcc gtttttcaat tcagatgttc tttttctttt ggagataaaa
    12001 aaatacccct ttagataatc atatctaaag ggggcaaagc ttcgcaactt tattttaaag
    12061 ctacaaatct ttgtcaggtg ataaaaaagt gtggaaccga tttcattgat tttattgggt
    12121 ttgtcgtggt acttgataaa cacgaaaaaa agaaagtctg gaaccactag atattactat
    12181 gtaaaaaaag ttggaaattt cccctacatg tatttggtaa aaattggatc ttaactatca
    12241 aaactctatt atccttaaac aagttaacag tgcttccaat gaactcaaag tgcttaccca
    12301 aaaaaagact tttcaatttt attcttgatt agagcttcat ttaataaatc aaagcaaaaa
    12361 tttcgaatct tgttattttt gttccgcaac tcatcaagca tttgttgaag cgtgcgacct
    12421 cccttgtctc ttgagataat cgtattgatt gctttaatct gcctggggag tggttcgcga
    12481 ctcttatatt tctcaaggtc gttcttgatt tcttgcagta cacttccagg agcaattccc
    12541 caacatatga ttaacaggtt aattgcgtta aacagttgct ttgcagccgg atgccatgtt
    12601 tcattaaaac ctgcttttcc attgatgctg tttgttacca ttccaatggc ttcagatgct
    12661 aatggatcaa aaagtgttaa tttgggatga tgaattagtt caaggaagtg attcgctgca
    12721 taggtaccac ataaaaaggt tccggtaaca tcaccatttt ttgctcgata agaaaaacaa
    12781 taatagctgt tagtaagtaa gtccttagta caacttcgac gttcttgccc gtttaacaat
    12841 cgaacatgag caatgggttt gatatcatat tcctgaatca gcttatctct aacctctgat
    12901 gatctgcacg gaagcatcac aaacacctcg tttcttgtct tcccgtttta cagtaaatca
    12961 actcccattt atatattgtt taaagggagc aaaacctggt taaagttctt ttttatttgc
    13021 aactcgacat cttcataaga acaattccaa agcgaactca aatatttcag aacaagcgat
    13081 atatcttgag atgtaattat cttgccttca ttttgacaaa aggtccgtca gtttcagtta
    13141 atagtctgtc ttgcggaatc ttttcgatca ttttacatcc attagacgat tgaatcattg
    13201 caggattaat cgagaagtaa tgacctgctt caacaatttc ttttagtaag gacaatgaac
    13261 cactatacca atgaaaaaca gctcccttta ttgaaaactc ttctaacatt tgcagaacta
    13321 tagattcagc cctccttgaa tgcagcgtaa taaatcgagg tcgatcactg atatgactca
    13381 acacatgacg gaaactttgg atttgttttg tttttgtagt aatgccttct cgtgagaagt
    13441 ctagtcctat ctcgccaatg tatgatgtcg tcttcgcaaa atcaatgaat cttttcattt
    13501 cagtaggagt atgtttattt gcatggagtg gatgtaagcc tagagccact cgaatatatt
    13561 tgaatttttt cagatgagaa taccccaatt caaagtaact tggtaaattt gtaactgcga
    13621 tagttgaaat acccttcttt tcattttcat tcgctaccac ataggggttt ttgtacaaat
    13681 ctatgtggca atggacatcg atcattttat ttcacatcct taagtaagac cgattaaacg
    13741 tttaatacca gttgtccctt tatcatcaat aagttccttt acctcggcca tcgctcgaat
    13801 aacaaggctt gaatattcat caatttcttc aataggcacg ccacttgaaa gcaataatct
    13861 ttttatttcc tcaatattat agttatgccc aagaaacgcc aacacagccc taagatcatt
    13921 aacagaagct ttgttgcccg tcaaatcgat ttcatcacta caaatatcaa tcccataaat
    13981 ttcagtatct gcattgatga catgcaatga tgctcttcta aaaatacagg gaacgcatct
    14041 tccacaacct tttgcatctc ttctaatcca gctggattta tgcccacttt ttccacagga
    14101 cactgaatca ggaatagcat tttgtaatac ttgttgattt ttgcactggc taattgcctc
    14161 accttttgtt ttcataccta acggatttaa tattggatta catatccgaa cactttgtat
    14221 aatatgactc agcattcgca aataattcgg atgagcagtt ctcgtgctgc aagttcctct
    14281 tcgagacggt gtaagaggta tatttaaagc gattgtccca ttctccggta ttaacaatgg
    14341 tatatcctcg ccaatactcg cagctgcgta gatgccgatg gcgagaaaca aaatggaacg
    14401 gcttctaaaa gttgtttcct tgcctgaagg gttctgacct gccctaactt gtaaatcaat
    14461 cagccttttg tcgttatcgt cttcatatgt aactccgtct cccgaattct cacctattaa
    14521 taaccagttt aaattaacgt tatagtgaat tccaatggat gctaaagttt ccgctgaagg
    14581 attactattt cccatttcaa tttcactcag gtttccttca gaaattccta tagctttcgc
    14641 aaattgaaat tggttttata cattttatcc gatatccaat ttcactcata cctttcacca
    14701 ccaatcgtca aattaataaa aagagggcag cccgaaatga ttccttcagg ctcccctcta
    14761 gatgcactaa tcatcttgca tgttagttcc acacattttt tactggttcc acagtttttt
    14821 atcacgggac atttttcttt aaatctatcc caacttactc cacggtcacg ctcttagcca
    14881 ggttacgcgg cttatctacg tcgttgccgc gtgccaggga agcgtagtag gacagcagct
    14941 gcagaggtac tacggaaagg gccggggaca gcagatccag cgtttgcggg atcacaaaat
    15001 gctgatctac cgattttttc agctccgcat ccccttcatg gctcagtccg agcacatgtg
    15061 caccgcgggc tgttacttcc ttgatgttgc tgacggtttt ctcgaacagg tcagcttgtg
    15121 tagccagtgc gataaccggt actccctctt cgatcagtgc cagtgtaccg tgtttaagct
    15181 caccggcagc ataagcttcg gagtggatgt aagaaatttc cttcagcttc agggaacctt
    15241 ccaatgctac cgcatagtcc aggccgcgtc caatgaagaa cagatcttca tagcccgcaa
    15301 tttcttcagc aaatttcttg atttcgtcgg tccggttcag gatgctttcc acttgctccg
    15361 gcaggctttt cattgctgcg atgacattct tgatgtaagc ctcgtctttc gtaccgagct
    15421 gctgagccag atgaaggcca agcaggtaga acgaaatcag catggttgta tatgctttgg
    15481 tcgatgccac tgcgatttcc ggtcctgccc aagtcaggat caggtcatcc gcttcacggg
    15541 ctacggaact tcctactacg tttgtaatag ccaaaatacg ggcaccgcag cgtttagctt
    15601 cccgcagggc cgccagtgta tctgccgttt caccggattg gctcacaccg attaccagcg
    15661 ttttgtccgt aatgattggg gtacggtaac ggtattcgga agcaacatcg acttctaccg
    15721 gaatgcgagc caggttttcg atcacatatt tcccgaccaa tccggcgtga tatgcggtac
    15781 cgcaagcgac aatgtgaatc cggtctatgt tcttgatgtc ctctttggac atgctcactt
    15841 gttccaggtt aattttatcc ccatccgcaa tacggcttcc catggtatcc cgataagctt
    15901 tcggctggtc gtagatctct ttcagcataa agtgctcgta acccgccttt tccgcggtaa
    15961 tcagatccca atcgacatgg aacatttccc gagaaataaa attaccctcg attgttctta
    16021 attcgacacc atcccgtgtc agaacagcca tttcaccatc attcagaata tatacattac
    16081 gggtatattc aaggattgcc ggaatatccg agccgatgaa gttttcccct tcacctactc
    16141 caatgatcag cgggctggcc aaacgtacgg caaccagttt atccggttca tactcggtca
    16201 atacaccaag tgcgaaggca ccccgtattt gttttacggc ctgctgaact gctttgacga
    16261 tatctccatc atacagttcg ctgatcaaat gggcaatcac ttccgtatcc gtttcagatg
    16321 caaaatgatg acctttggcg ataagttctt ctttcagtgc aatgtaattt tcgataattc
    16381 cgttatgcac aactgcaaat ttggaagagt catccgtatg aggatgtgaa ttcacgtccg
    16441 atggtttccc atgggtagcc cagcgtgtat ggccaatccc tacgcttcct tgaacaggtt
    16501 cctcattcag tttggactcc aaaatagcca ggcgtccttt cgctttctta acctgaagac
    16561 cttgttttgt ttgaactgcg attcccgcag agtcgtatcc tctatattca agcttgctca
    16621 gtccattgat cagtacttct cttgagttcc ggtttccgat atatccaaca attccacaca
    16681 taagtcgatt ccctccgtta ttgaataagc ctgctgacta ttgatgtcac atgcttcgtt
    16741 cattcaagtt ttccggatcg gaatcctttt gaggccaaca caaataaagg tacgctatct
    16801 gtcatttttt gaagcgtatc taggtctttt cgataatttt gggcagcaca aaaaaaggtc
    16861 cgatccctta aattttccga aaaatcatat gcatcattat gctggaatct tgtttacccg
    16921 gtcacccggg cagtttgctt tccaagctta cggcatgaat gaaatgccgg aaggtccccg
    16981 ccgaatgttt cgaacacctt cacctcgtca acttagatgc tcttcgcttc ttcttcccac
    17041 ctgccattgt ctttccttac gctccttcga caaaacagat atgcagccag gctgccggga
    17101 tgaaaaagac tccgatgcca tcctaagttc tggcgcttat gttgcttcct acctctaccc
    17161 tacctttctc ttcttgagta aaaaaacata tatacatcat attcattttg gagccgtaat
    17221 gcaactccag aaaacgctga gtttaaaaaa aaactaaatg aaatcgttta tatatgtcga
    17281 tttataggag tttttattaa ttttataatt ttgatttcca tccgaacgga tacaagatat
    17341 agttaaattt gaaccgtatt tatctatatc ttctctatta aacactcaat tgtggttttt
    17401 atatagctta aggtgggtca gctaaagagt tacacccgtt tttggagccc gtgaaaatac
    17461 cgctaatttc aatctctttt gcgggttccg ggcaaacggc tggagggata tcccaccctc
    17521 ttatacagac catttctccc gtaaagttgg tttttcaaaa gctaaaacca ccaaaatttt
    17581 aatattttgg tggtttttta tagcccggct atttctattg atctagctat ctatgaaact
    17641 caaaaactag caaagctctc tttgcactat ttcggcaatt tgctgcacat gtgtttccac
    17701 ctgatcctta tccggacctt ctgccataac acggatgagg gactctgtgc ccgatggccg
    17761 aaccagaacc cggccattgc tgccaagctc tgcttcaacg gcttggataa catctgcgac
    17821 tgcctgatta tctttcagct tgttcttatc ccctacacgt acattcacaa gtacctgcgg
    17881 gaatttcctc atgatgctct tcatttcatt cagttttttg ccggctttcc tcaccgtatt
    17941 gaccagctga agaccggtaa gaataccgtc gcccgtagta ttgtgatcaa ggaagatcac
    18001 atgcccggat tgttctccac ccagattata gccgccttta cgcatttcct ccatcacgta
    18061 gcggtcgcct acagctgttt gaaccgcttt taaaccgacc ttctctatgc ctttgaagaa
    18121 tccgatatta gccattacag tcgttacaat ggtaccctgc ttcagcttgc cgctttggtg
    18181 catatcgtga ccgcaaatac taagaatgaa gtcgccgtct acttcttctc cattctcatc
    18241 cactgcgatt aagcggtcgg catccccgtc aaaagcaaga cccaggtccg ctttctcttt
    18301 gacgaccaat tctttcagct tttccggatg agtcgagcca caatggtcgt tgatgtttgt
    18361 tccgtttgga tatgccgcca tcgtaattac ttctgcgccg aggtctttaa atactttcgg
    18421 cgccagttca taggcagccc cgttagcaca atcaagtaca attttcatgc cttcaaaaga
    18481 tacatctacc gtcgatttta aaaattccgc atacttgaat ttgagttctt catcgtccag
    18541 caccgatccg atatttccgc caatcggtct aggcagttca tcggtctcgg catcaagcag
    18601 gcgctcaatc tcaagctccg tctcgtccaa cagcttaaaa ccgtctcccc gaaaaactta
    18661 atgccgttat cttccacagg attgtgggaa gcagagatca taactcccgc gtccgcatcc
    18721 aatgttcttg ttaagtaagc cacggccggt gtagagacta ccccgacccg gattacgttt
    18781 gctccaatgg aaagtagccc tgctaccagt gctgcctcca gcataggacc ggagatacgg
    18841 gtatcgcggc caataatcac cttgggatgt tccgcctttc ctgtcagtac atacccgccg
    18901 catcggccga ttttgtaagc cagttcaggc gtcaattctc tgtttgcgat tccgcgtact
    18961 ccgtctgtcc caaaatattt ccccattttg ttcattcccc ttttctgcta tcactttgcc
    19021 cttttctttt tttcggtaat ggtaacagtg gctttaatct cgccggttgc atttttaata
    19081 tatggcggaa gattaatatt gaccgttact tcatgatcac ctggcggaag attggtcacg
    19141 tctatagcag cctgaatatc ttccagtttc acctcattga ggagcgtttg cgctccttcc
    19201 atggtaaagc taatttgccc ggattccggt gttgtaattt tggcattcat attcttcgca
    19261 agccccgtta tatttagggg gaaattttcg acctgcttgg tcaccgaagg tacgatttcc
    19321 accgtcacat ccactttatc cggatctgtc tgtgttacat tattccgatg aggaatatcc
    19381 aatgtaaatt tcttcgtttc cttcaaatcc gccaaattca cttcaggccc ttcataaaac
    19441 tccattttat ccaaatcatt aggcgagttt gaatatactg tcactttatc ggtactctgc
    19501 ttgacagagg caaccgcaaa tcccggcggg ggtccccaac caatttgatc tgtaaaggca
    19561 tagccttaaa cggcatcgtt accggcactt ctacatccac tacggcaggt gatacctcaa
    19621 aatcaagctc tttacccttt ttatcaaagg cccttagttt cacctgctgt ttaatagttg
    19681 aatccgcctg atccacggag atctccccgt gtacggaatc taccaggtcc gctttgctgt
    19741 ctggtacggt gacatgtacc cggttaggct taactatagg ttgtcctgct ttaaagcctt
    19801 ctttcggtgt tcccgtcaca tcaatgacaa caggaacctc ttttttctgc tgcttctcaa
    19861 tggcaacctt caccgttcgc gggtaaattt cccaatccag ggaagaaggc agccctaccg
    19921 ccataggagc gagatagtat tcaccagcgg aggccttcgt taaatcaagc tcgatcttat
    19981 aattactggt actaacttta tcaatggcaa actgtctgcc ttttagacga atcgttactt
    20041 cagacggttc tatggatgag acataatact ggctggagtc atatttcgga actacggcca
    20101 cattactgat cgtttgctcc tttaagccca ctgaagaaat atttcccgtg ttcccgtcca
    20161 tacggacaac cacccatagc ataatgccca gcataagggc gacaattttc acaacatttg
    20221 gatttcgcag ccacttatcc acgtcttcgt ccctcccacc atttcttgaa agggttcttg
    20281 tctccgctgc gtccctgcgg tttcaactgc tcgaacaatt tggagattaa agactcttcc
    20341 ttgatgtcgc ggacaatttg tccattaaga gaaagcgaaa tttgtccggt ttcttccgaa
    20401 acgatcaaac aaaccgcatc tgaaacttca ctcatgccaa tagccgcacg gtgcctggtt
    20461 ccgagctcct tgctgataaa aggattctcc gaaagaggca aataacatcc ggcagccata
    20521 atctgatggc cgcgaatgat gacggcacca tcatgaagag gtgtattagg gataaaaata
    20581 ttgatcagca gttccgaact aattttggac tccataggaa tcccggactc gatataatca
    20641 gtaaggcctg tctctttttc aaacacaata agcgcgccga ttttacgttt ggataaataa
    20701 ttcagcgctt tgataacttc agcaattcgc ttgtttacat cctgatcaag atcattgctt
    20761 ctgctaaata attttcctcg tccgagctgt tccagagccc gtcttaattc aggttgaaaa
    20821 attatgatga tggcaataac ccgatgttaa acatctggtt catcatccac tgcagggtat
    20881 taagcttaaa caaaaaactg aacgcccagg tggccaccac gatgaaaatc cctttcatca
    20941 gctgaatggc tcttgttccc cggatcagca taatcagttt atatatgaca taactgacaa
    21001 tcagaatatc aacaatgtcg ttgaatgaaa aaacagcgaa gtattccatc ctttatcccc
    21061 cagaccaaca ccttaccgat taacgtagta tttctattgt tttctgtcta ttcctagatg
    21121 ataccacatt caaagcaaat cttctattgg ggggaaatgc cataacttcc accggcaaaa
    21181 aaacaggaca taaataagcc tccctgttag ggaggccagt tctttatttc gtaaacgagc
    21241 taaagaattc attcacttta taccacagcc atccaattga ttcatttatg cgctgtacgt
    21301 ttcctgagat gtgtgccgtg gaagccaaat tcagcgtgcc gtcaataagt gtaagatttc
    21361 cgtccaactc accctctaca tccagctctc caccttgtac gacaaggttc ccgttaacgg
    21421 taaccccttc aggaacaata actgtattcc catcaataat gacttgaccg gattcaggcc
    21481 ccttgaccat gacctgcttg ttttcgtccc aaagagtgag aaagcttcct aacatgacta
    21541 caacaaaaac gactgcaacc gagaggcccg gatgccttcg cagccaatgg accactgagt
    21601 tacgtttctt ctcaggaggc agtttggtca tgatacgatc ggtaagatcg tcaggcaatt
    21661 gcgcggtagg tatagacttg acga
//
