LOCUS       NZ_CP020557            23968 bp    DNA     circular CON 24-JUL-2024
DEFINITION  Paenibacillus larvae subsp. pulvifaciens strain SAG 10367
            chromosome, complete genome.
ACCESSION   NZ_CP020557
VERSION     NZ_CP020557.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus larvae subsp. pulvifaciens
  ORGANISM  Paenibacillus larvae subsp. pulvifaciens
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 4666454)
  AUTHORS   Dingman,D.W.
  TITLE     Paenibacillus larvae genome sequencing
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4666454)
  AUTHORS   Dingman,D.W.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-MAR-2017) Entomology, CT Agric Expt Station, 123
            Huntington St, New Haven, CT 06504, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: FEB-2016
            Assembly Method :: SMRT Pipe HGAP assembly v. February-2016
            Assembly Name                     :: sag10367-hgap-022916
            Genome Coverage                   :: 214.2x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002082155.1-RS_2024_07_24
            Annotation Date                   :: 07/24/2024 02:27:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,275
            CDSs (total)                      :: 5,166
            Genes (coding)                    :: 4,634
            CDSs (with protein)               :: 4,634
            Genes (RNA)                       :: 109
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 532
            CDSs (without protein)            :: 532
            Pseudo Genes (ambiguous residues) :: 0 of 532
            Pseudo Genes (frameshifted)       :: 400 of 532
            Pseudo Genes (incomplete)         :: 184 of 532
            Pseudo Genes (internal stop)      :: 26 of 532
            Pseudo Genes (multiple problems)  :: 72 of 532
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:07:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1352507
            Orig. end                         :: 1376475
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP020557.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Dr. Adriana Alippi,
            CIDEFI-CIC, Facultad de Ciencias Agrarias y Forestales, Universidad
            Nacional de La Plata, 1900 La Plata, Argentina.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23968
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="4"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..23968
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23968
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13968](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13968
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(475..489)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.0"
                     /tool="antismash"
     gene            complement(622..1227)
                     /locus_tag="B7C51_RS07440"
                     /old_locus_tag="B7C51_07440"
     CDS             complement(622..1227)
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1188: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019536588.1"
                     /locus_tag="B7C51_RS07440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_07440"
                     /product="DedA family protein"
                     /protein_id="WP_079940436.1"
                     /transl_table=11
                     /translation="MAEIISSILVFLEGLGYWGVMLGLMIEIIPSEIVLSYAGYLVYKG
                     QIGYLGAVFFGTVGGVLAQLFIYWISRYGGRPILEKFGKYILIKKHHIDKSEEWFNKYG
                     TGVIFTARFIPVVRHAISVPAGLAKMKVSRFILYTTLAVIPWSMLFVFFGQKLGENWEK
                     IDDYASAYMPYFIAGAILLTGAYLIYALWFKRKKTRKI"
     misc_feature    1212..1226
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.19"
                     /tool="antismash"
     misc_feature    1338..1358
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 24.28"
                     /tool="antismash"
     gene            1421..1873
                     /locus_tag="B7C51_RS07445"
                     /old_locus_tag="B7C51_07445"
     CDS             1421..1873
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009673286.1"
                     /locus_tag="B7C51_RS07445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_07445"
                     /product="cupredoxin domain-containing protein"
                     /protein_id="WP_083039422.1"
                     /transl_table=11
                     /translation="MFKSLVIRKAHLVATGFILLVVLAAILFFTKKDSIVSTIAPAGQE
                     RTFQMVTTEFKTTTKDGKQIEAYRWDPGTIVIKKGEKVKLNIYGVNGETHPFLIEGLNI
                     KGEVKKGKETVVSFTADKPGTYRIICLTHPDIAHEGPMVGYIEVLD"
     gene            1951..2262
                     /locus_tag="B7C51_RS07450"
                     /old_locus_tag="B7C51_07450"
     CDS             1951..2262
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006677125.1"
                     /locus_tag="B7C51_RS07450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_07450"
                     /product="dehydrogenase"
                     /protein_id="WP_083039424.1"
                     /transl_table=11
                     /translation="MQKPREKHNQPFPTHRTIRRACSRELYRTVKRLKKRIPKAKMKEA
                     ENFYIKKVLLHLPFIVENEQNRKELVDWWDEHVSSFIAELWEVDRHDLSRAFRDAFGG"
     gene            2609..3187
                     /locus_tag="B7C51_RS07455"
                     /old_locus_tag="B7C51_07455"
     CDS             2609..3187
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000963370.1"
                     /locus_tag="B7C51_RS07455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_07455"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_077995985.1"
                     /transl_table=11
                     /translation="MSVDRRKMIVEAAAKSFAFFGYKATTMDQVAKLANVGKGTIYTFF
                     SNKEELFGEIVRQLNKELISVAERAIDPNKSFVENLHIFLYAMLDFRRKHELTIRLSHE
                     IDEMGTMAAKEGMEKVEEAMLSIVAKKVKEAVDKGELKPCDPEKTAFAMMKMYIAFVHD
                     WDAYHTEPLEKKDLAELFELYFMEGLAVR"
     misc_feature    3211..3226
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 20.96"
                     /tool="antismash"
     misc_feature    complement(3220..3235)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.08"
                     /tool="antismash"
     gene            3326..5611
                     /locus_tag="B7C51_RS07460"
                     /old_locus_tag="B7C51_07460"
     CDS             3326..5611
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03062.1"
                     /locus_tag="B7C51_RS07460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_07460"
                     /product="YhgE/Pip family protein"
                     /protein_id="WP_083039426.1"
                     /transl_table=11
                     /translation="MKNAGFFTKEWAAIFKNKKVLVSICAVALIPLLYSSMFLWAFWDP
                     NEKLNELPVAVVNMDKGANFEGKELHVGEEFVNKIKESKDFKWDFVSQEKAIQGMDENK
                     YYMTVVIPDNFSEKATKVLDDHPTASDLIYIPNESLNFLSSQIGSTAIEKMKAAISKNL
                     TKAYAEAMFKSIGKISDGFVQAADGSLQLKDGSIKIKDGIVQVDDNLLKINEGTLTLKD
                     GVTKIHDKLGELTKGASRIQNEGTSVVADGAGKLADAQKQLSVQGANKIQSGLDELKSG
                     SAELSEKLGELEKQLKASMTEMNVLPAKAKELNDGAHQLYKGTQNLSTNSEKLSHGSKK
                     IQSSLSEVLKNHPELAKDINFMTAMGATKQVTDGMDTLNKSVNNLLLPGAKGISGGTDL
                     LMSKVKDIGKLAQLPIGVQKLHEGSTKISNGIAQAVVGQNEFVKNFNTFGQKLNELSAG
                     AKQVDGKMNDLIDGSSKLKDGAHQLGGGVDKLTDGTNQIRTEGTEKLNEGAAALVEGQT
                     ELTDKLAEAADKTGDVKGDDSNYNMFAEPVKVTEEKRGPVPNYGTGFAPYFISLGLFVG
                     ALMLTIVFPIKNPVTPPKSAFSWFLSKFGSMLLVGTVQAILVDAILLYGLKIEVQNVGY
                     FFFFSLITSWVFMAILQFLVTAFNDAGRFIAIILLILQLTASAGTFPLELIPTPLQKFN
                     AFIPMTYSVSGYKAVISSGDYSQMWHSVLVLGSVSVVFALLTYTVLAISFKKHYSNLPG
                     NREESITA"
     gene            <5682..>5783
                     /locus_tag="B7C51_RS07465"
                     /old_locus_tag="B7C51_07465"
                     /pseudo=""
     CDS             5682..>5783
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019258194.1"
                     /locus_tag="B7C51_RS07465"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="B7C51_07465"
                     /product="SMR family transporter"
                     /pseudo=""
                     /transl_table=11
                     /translation="MHKDIKSFLFMIIGFSLSFLLLSLAMNTIPMGTA"
     gene            5875..6666
                     /locus_tag="B7C51_RS07470"
                     /old_locus_tag="B7C51_07470"
     CDS             5875..6666
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007715623.1"
                     /locus_tag="B7C51_RS07470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_07470"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_158530321.1"
                     /transl_table=11
                     /translation="MRRTFVITILALVLFSTASFPAHAGFSDKDKEVNMLYGPVKGRDY
                     FEPRGDIVWEVPMGKKMMALTFDDGPDPDETVQILDLLKQYEAKATFFLIGNRVIRYPD
                     LVKREASEGHELANHTYSHAYFNRASKERMIKEIKDAEEAIFQASGVHTCLFRPPGGYY
                     NQILVDVCKANNYTPILWSWHQDTVDWKTPGVKKIVNKVLNNARGGDIVLFHDHVEGST
                     QTIEALKQILPELKKRGFRFVTVSELMGQRNLNQAKPLNKP"
     gene            6816..7379
                     /locus_tag="B7C51_RS07475"
                     /old_locus_tag="B7C51_07475"
     CDS             6816..7379
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018887035.1"
                     /locus_tag="B7C51_RS07475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_07475"
                     /product="L,D-transpeptidase family protein"
                     /protein_id="WP_226989756.1"
                     /transl_table=11
                     /translation="MEIDPLYNRLWVLVDGKRIKQFPVGLGKQKTPTPIGEFTVINKYK
                     NWGSGFGTRWIGLNVPWGIYGIHGTNRPDSIGRHQSHGCIRMYNRNVEILYEWVKIGTK
                     VTIYGHPLGPPYEDPRPLAAGDSGIDVQLIQYRLKSAGYFNGICNGKFGPQTELALKRF
                     EKDHDLPIDGVMGRQDYEALGLWE"
     gene            complement(7762..8307)
                     /gene="yyaC"
                     /locus_tag="B7C51_RS07485"
                     /old_locus_tag="B7C51_07485"
     CDS             complement(7762..8307)
                     /codon_start=1
                     /gene="yyaC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019637556.1"
                     /locus_tag="B7C51_RS07485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_07485"
                     /product="spore protease YyaC"
                     /protein_id="WP_083039432.1"
                     /transl_table=11
                     /translation="MQAEHPVSSKEYWKKVKGEELASHLSEIVPSFGDNLPVFVCIGTD
                     RSTGDALGPLVGTYLEEHGYPFVIGTLAYPCDASNIHHRLNEVPYPSKVIAIDACLGRT
                     ASVGLYQVSNQPLFPGKSLGKDLPCVGDFTIAAIVNSEGPRQYAVLQTTSLHKVMLMAK
                     EITTAILQSFPLPSLAES"
     misc_feature    complement(8440..8457)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 18.49"
                     /tool="antismash"
     misc_feature    complement(8570..8589)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 20.63"
                     /tool="antismash"
     gene            complement(8741..9445)
                     /locus_tag="B7C51_RS07490"
                     /old_locus_tag="B7C51_07490"
     CDS             complement(8741..9445)
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0055070 - copper ion homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003389538.1"
                     /locus_tag="B7C51_RS07490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_07490"
                     /product="copper homeostasis protein CutC"
                     /protein_id="WP_083039434.1"
                     /transl_table=11
                     /translation="MIFEAIAISVTDAKIAAQHGADRLELITGIKEGGLTPSLGLIEGV
                     LETVDIPVQIMVRPHSQSFVYGEDEIRTMIRDIQKLKPFAPKAGIVLGVLTPEGHIHEE
                     ALKRMLDAAGDLEVTFHRAFDELSDQFSGLQILSQYPQIKRILTSGGKPNVMDAADRIK
                     ELVQASRKTHLAILAGSGLRAEGLADFVAGTGVTQVHFGSAVRGPGGSSAPVSAEEISK
                     VRRILDELSAQS"
     misc_feature    9575..9590
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.08"
                     /tool="antismash"
     misc_feature    complement(9670..9685)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 25.53"
                     /tool="antismash"
     misc_feature    complement(9752..9767)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 23.25"
                     /tool="antismash"
     gene            9759..9884
                     /locus_tag="B7C51_RS28420"
     CDS             9759..9884
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS28420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_257125660.1"
                     /transl_table=11
                     /translation="MANDIFELDVQIEMMNEEENSNQEVGYTGHSKNWLSFCVSC"
     gene            10001..11932
                     /locus_tag="B7C51_RS07495"
                     /old_locus_tag="B7C51_07495"
     CDS             10001..11932
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="B7C51_RS07495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_07495"
                     /product="lantibiotic dehydratase family protein"
                     /protein_id="WP_083039436.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6.9e-161,
                     bitscore: 534.7, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.5e-14,
                     bitscore: 51.9, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLTREIPDPHAKPGQDKNLFQPLPFFMVRTPLLSIEKYKQLTES
                     GKPGILGPLIDQSHDPVVREAIAVASLSLLDSLPNLTNMDQPRKQDQAIKGFLRYMLRM
                     TTRPTPYGLCSAVGFGRFGNKANVAMGEVSGHQKQSRPDMSWLMQMVRKLEADLDLVLQ
                     LRVRSNSMVYFTGSRAKLPYVTRYGQREIETMSQMESASIRLTPVVQFVLQEAERPVLF
                     CELADRVKQKYPDTPDEKIIRFLWQMFQQEFLISELRPPLMIESPFDYLRERLANIKGI
                     DEEKQSLQAIAEQLDAYDRLEIGEGEAVYRKLVAQMRSLADAKNPIQVDLSLNKQAAEL
                     PHGIGEEVAKAAEVLWLLSVKTVDEANLEAYREEFTERYGLQREVPLLELLDPDLGLGA
                     PAGYEYPPSRRRQEIIAANSQLDALLLLWMTQALHRGEIEVELTEDHIQQLVHVTPDNP
                     KEAPMSLELYFTIASPDKSSLEQGNYRLILGPNPGSQGAGKTFGRFVRFMTEQEHTSLA
                     EIQKYEQSLHPDAVFAEVVYLPNAGRAANVALSTNIRPYEVVMGTNPSEGEKISLPLTD
                     LMVGSTMDHFYLKSKSLGQEVIPVTLHMLNFMHTPNVYRFLRELSIMRTCNWKPFTWGT
                     SYSPTFSR"
     aSDomain        10502..10783
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_B7C51_RS07495_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.40E-16"
                     /identifier="RREFam001.1"
                     /label="B7C51_RS07495"
                     /locus_tag="B7C51_RS07495"
                     /protein_end="261"
                     /protein_start="167"
                     /score="51.9"
                     /tool="antismash"
                     /translation="SNSMVYFTGSRAKLPYVTRYGQREIETMSQMESASIRLTPVVQFV
                     LQEAERPVLFCELADRVKQKYPDTPDEKIIRFLWQMFQQEFLISELRPP"
     gene            11943..12620
                     /locus_tag="B7C51_RS07500"
                     /old_locus_tag="B7C51_07500"
     CDS             11943..12620
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF025394.4"
                     /locus_tag="B7C51_RS07500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_07500"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_237089138.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 5.2e-20, bitscore:
                     70.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAELLPEVYRWALYLQQEGLLTRLVVDTYEPEIERYGGPALIGL
                     AESVFATDSQTTALWLGLKRTGQIGLSMEMIGTISVIDIMEQFNVPFADQLKLLDSMAF
                     RKEYLEEFRKERRLYLSLGDSFHDWENLLKHRDGKILYEGMKARRHALRQYQKAVRDQE
                     EDGLLYNSFYNILSSMIHLHLNRLLGIDRRREKKVLTLALHTLYNLQYIRGNRKAKENE
                     IHE"
     gene            12613..13968
                     /locus_tag="B7C51_RS07505"
                     /old_locus_tag="B7C51_07505"
     CDS             12613..13968
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="B7C51_RS07505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_07505"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_158672808.1"
                     /sec_met_domain="LANC_like (E-value: 3e-61, bitscore:
                     205.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNAKSWQPIHSLELQHAIESCARDVAGRLSEPSLVRELSKTAQE
                     RFGRPGPVWSDLDLATGYPGLCILFGELDRLFPGEDWDVIGHSHLVELQCIIQAQKLSS
                     LSLWGGLSGIAIAVRALSRGGIRYQGFIQTLQGVFLRHYQRNLSQAMLHLENGVHMGDY
                     DVFEGFTGIGRYLLAFAEQPELRKVLCEVLTYLVRLSENKTVDGQSVPGWHIPASHLVL
                     PQEKIDFPSGNYNCGVAHGIPGPLALLSLSLSAGVEVPGQSQAIRRIAEWLLEWKQEDR
                     YGPFWPQRVAWEEQQTGLGGSGWQREAWCYGSPGVARTLWLAGKALDESGWKQTSLETF
                     IALAHRPEEDWNLHAPTLCHGFGGLLQMTQRMYAESGDDQLNVVRERLAWRILESFDRN
                     TPFGFSEVIKTEHETSVLHSPGLLQGAAGTVLALLGLCSTQEPEWDQVLLIT"
     gene            complement(14255..15571)
                     /locus_tag="B7C51_RS07510"
                     /old_locus_tag="B7C51_07510"
     CDS             complement(14255..15571)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1212:
                     sodium:dicarboxylate symporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009711578.1"
                     /locus_tag="B7C51_RS07510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_07510"
                     /product="dicarboxylate/amino acid:cation symporter"
                     /protein_id="WP_083039440.1"
                     /transl_table=11
                     /translation="MNLTYTSWIVTAILIGFLYFLKKKKISFGIRVLIAMALGVAVGII
                     FGNQAQSIGVLGSIYINLIMMLVIPLVISSIISSMTSLTDIKQLKTVGVKTIGLFLLLT
                     AIASVIGILVGLVFDPGSGISIADTSGYKVREVNFTAFLLDMIPKNPVAEMSAGKIIPV
                     IIFAMIIGVAITIESERKPETMKPVKDVVNSFTQVMFRVTKMVLKLTPYGVFGLLTAMA
                     SKYGLGTLLELGKFILAVYVACILHTVITYTGFVGLAAKVNPLRFFRKIFPVMVVGFTT
                     RSSYGTLPVTMKTLTERVKISERIVSFVAPLGATINMNGCGGLYPAIVCIFIAKLYGID
                     LTFTSYLLIVLTSVLASVGTAGVPGTASIMATVVLSSAGLPVAGIALVMGIDAIVDMAR
                     TAVNVTGTTVAALIVGESEGEFDREAFNREDDTLQLNPS"
     gene            complement(15860..16843)
                     /locus_tag="B7C51_RS07515"
                     /old_locus_tag="B7C51_07515"
     CDS             complement(15860..16843)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS07515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B7C51_07515"
                     /product="hypothetical protein"
                     /protein_id="WP_083039442.1"
                     /transl_table=11
                     /translation="MKGWNKLFLSLVCGAWVLMLAACGGKEDPNDHLVKAFDQLKAVSS
                     YESESTVKLKINAPDKAKEDPQTEAAVKALNDAKIQVASVVDNKKKQSESTISASIKVP
                     PVSFDIKLPVLVDEQNEKVYVQTDNLYENFSMFLPPQIKGKLLEIDTKDSSSQNLKPEE
                     VAKIQKAAQEELLKAVKDKKIKLTEQEVTKEDKDKNIKNKYKAEVDDAGLKELITNILT
                     STSKGLGQEASQKDLDELKKSMNEATFKNTSLVAGLDKDDNFVTMDLNVGIEAKADGET
                     FGIELALNSAYSKMNQEVKITIDPSKADIIKSDELDKYFGSMKHGL"
     misc_feature    16942..16953
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.78"
                     /tool="antismash"
     gene            complement(17191..18591)
                     /locus_tag="B7C51_RS07520"
                     /old_locus_tag="B7C51_07520"
     CDS             complement(17191..18591)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015297 - antiporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013188.4"
                     /locus_tag="B7C51_RS07520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_07520"
                     /product="sodium:proton antiporter"
                     /protein_id="WP_250644867.1"
                     /transl_table=11
                     /translation="MHRRADIQIHLIFELILPIISYIVAELFHFSGIIAAVSAGIMFAF
                     EFKRISQAEAERSTISQSIWEVILTILNAFVFLFLGAQLPSAIKNIREILETQLTLLAI
                     VVISITILIFLIRFVFIGVLMPKVIKDNNSYSLKNHLIITFAGVKGTVSLAAILSLPVY
                     LNSGNYFEQRDLIIFITMCVILLSMVIGSIMIPIISPKINQKDLTPLVIEIYDKVIKQL
                     YKLRRNSDKKSEYDMVISKYRKRKEEVIEEYALGKFPKILRKVRKQMMKIEMEGLMKLY
                     KANKISYPAFSRYQKILNIINTFLYKDKWVKIKYSGKLIFIILKKWLGRGEQLTQTSED
                     LFKEIKFIFSYNTKKIKKMEDNDSLSANEYFVFRNLLEERIDINKQLMKGRFLSSQLVG
                     IQLKYMNQLLEGFAIEREVISAYHEEHLINSYEHAELIQNVDTIEWYSLDPNRNTTIYR
                     WLNKINIK"
     misc_feature    18613..18626
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.07"
                     /tool="antismash"
     gene            complement(18642..19217)
                     /locus_tag="B7C51_RS28260"
                     /old_locus_tag="B7C51_07525"
     CDS             complement(18642..19217)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015297 - antiporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013188.4"
                     /locus_tag="B7C51_RS28260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_07525"
                     /product="cation:proton antiporter"
                     /protein_id="WP_083039446.1"
                     /transl_table=11
                     /translation="MEMISFFFVFFLATICSLICKRYFPLFPMPILQVGLGILIGLFPS
                     FDKFQFEPEIFLILIVAPLLFNEGKNVDLESIWKSKTNILLLSFILVILSVLVLGPYIH
                     WLLPAIPLAACFAMAAALGPTDAVSVVSISKTVKIPGKTLHLLENEGLFNDASGLILLQ
                     TAVMALLYGSYSATGLISQLIISTLGGS"
     misc_feature    complement(19236..19249)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 21.69"
                     /tool="antismash"
     gene            complement(19257..19535)
                     /locus_tag="B7C51_RS07530"
                     /old_locus_tag="B7C51_07530"
     CDS             complement(19257..19535)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B7C51_RS07530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B7C51_07530"
                     /product="hypothetical protein"
                     /protein_id="WP_083039447.1"
                     /transl_table=11
                     /translation="MLMEIRLTKAYTTEKSEFSTGKKEIDSLYSFGIQKAKIESVLMPL
                     GLITEILYSFLPIGTIIKRIIGTEISRTKVMGTSRVNRITTAPRIVR"
     misc_feature    19605..19619
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: weak, score: 17.37"
                     /tool="antismash"
     gene            <19607..20211
                     /locus_tag="B7C51_RS07535"
                     /old_locus_tag="B7C51_07535"
                     /pseudo=""
     CDS             <19607..20211
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013083774.1"
                     /locus_tag="B7C51_RS07535"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="B7C51_07535"
                     /product="ATP-binding cassette domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="IQSAKGATEPLCRFWTSLRRNMRAENQNRMEILYLFIKSVLATVK
                     TNPFCRISRSRHNRVRLPLLSGRAGPAKQPSSP"
     gene            complement(20329..20721)
                     /locus_tag="B7C51_RS07540"
                     /old_locus_tag="B7C51_07540"
     CDS             complement(20329..20721)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024919.4"
                     /locus_tag="B7C51_RS07540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_07540"
                     /product="C39 family peptidase"
                     /protein_id="WP_198041853.1"
                     /transl_table=11
                     /translation="MGDVTGERIGFSVYHGPVYDLVESILPGRAVDLTGESFDRVLQSI
                     SEGQPVVVWTNVTFASVGNWVTWNSKNSPVKATFSEHAVLLVGYDEDNVYVNDPLDGTA
                     SKKLDRKDFLDSWIQMGSQAITYIDA"
     gene            complement(20694..21125)
                     /locus_tag="B7C51_RS07545"
                     /old_locus_tag="B7C51_07545"
     CDS             complement(20694..21125)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024919.4"
                     /locus_tag="B7C51_RS07545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_07545"
                     /product="C39 family peptidase"
                     /protein_id="WP_083039451.1"
                     /transl_table=11
                     /translation="MKKKSWMYVLIALIGIIMIWPGFNNALGKAIKARKEAAMEKNLSV
                     EETSIPSSTPEPMQTPEPLPAEKLLAVPIISQNPELYNGCEITSVAMMLKAAGHPVDKM
                     TLAKQVAKDSSPIRRDENGNILSWGTQTRDLWEMLQVNV"
     gene            21343..22800
                     /gene="cls"
                     /locus_tag="B7C51_RS07550"
                     /old_locus_tag="B7C51_07550"
     CDS             21343..22800
                     /GO_function="GO:0008808 - cardiolipin synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016780 - phosphotransferase activity, for
                     other substituted phosphate groups [Evidence IEA]"
                     /GO_process="GO:0032049 - cardiolipin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cls"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020156780.1"
                     /locus_tag="B7C51_RS07550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B7C51_07550"
                     /product="cardiolipin synthase"
                     /protein_id="WP_024094946.1"
                     /transl_table=11
                     /translation="MYIINFFVSSLPFVTLLNILLAITIIFLERRNAATTWAWLLILFF
                     IPVLGFILYIFFGQNLSRRRIFNLNTELTAQLRKEIKGQKELLDRNSFQFNHPTLQEYR
                     STIYLNLINGYGVLTQDNGVEIYTDGAAKFKALFEKIREAKDHIHMQYFIFKNDVLGKK
                     VVQALAEKAREGVEVRLLYDAMGSSRVPGRFFKPLREAGGKVAAFFPSLFFPFINYRIN
                     YRNHRKIVVIDGEYGFVGGYNVGKEYIGLKKKFGFWRDTHLLIHGSAVESLQSRFFLDW
                     NNASSDKLEFDLRYFPEKTYTGNIPIQIVSSGPDSEWEQIKNGIIKMIYSAEKSVYIQT
                     PYFVPDESLMHALRIAALSGIDVRIMIPNQPDHIFVYWASFSFIGELLDIGVKCFIYEN
                     GFIHAKMLVVDGKVASVGTTNFDIRSFKLNFEVNAFIYDTNVAGQLYSIYERDLLKSRE
                     MTYEMYRNRSLIIKFKESISRLLAPIL"
ORIGIN
        1 tccccgtatt gccgcatcat ttcctgacgg gcaaccgcaa ttttatcctg ataatccggc
       61 gcttccctat cagggttctt ctgcttaaaa gccgtcatga cggcctgtac gtgtttcgga
      121 cgcggtcccc acgtacccag cacatgtccg cctgtatccg tgaaaatagc cacgggaata
      181 gctcttcctc ccatggtaag aaactgatcg atgacatcca gatgctgctc caggataagt
      241 acctctaccg ggataccgct attctccaaa gacctgaaga taacgggtac attgcgtacc
      301 acatctccgc accattcggc ggctaccaga agacagcgaa gatcatcccg gttttgcagg
      361 gattcgaaaa attcacggtc ctcttcgtta tcccaggaaa aagcgtccat ccactgcctt
      421 aaggcgttct gattggtttt catactgttt atgaactgct cgggggtcaa tccctgtccg
      481 aatttatccg acagctgctt actcattgtt caccctcctg tcatgacatg aattaccttt
      541 atattagcaa aaaaaggaga gggctccaac ttcctgacag gaagaaaccg gtctccttgt
      601 atctctatca tttccataac attaaatttt acgggttttc ttccttttaa accagagtgc
      661 ataaatcagg taggccccgg ttaacagaat agcccctgca atgaaataag gcatgtaggc
      721 actcgcatag tcatcgattt tttcccagtt ttcgcccagc ttctgcccaa aaaatacaaa
      781 cagcatggac cagggaatca cagccaaagt ggtataaaga ataaaacggc tcaccttcat
      841 tttggccagg ccggcaggaa ccgaaatggc atgacgtaca acaggtatga aacgcgcggt
      901 aaaaattacg cctgttccgt atttgttaaa ccattcctct gatttatcaa tgtgatgctt
      961 tttaatcaga atatattttc cgaacttctc taatatcggg cggcccccat aacggctgat
     1021 ccaataaata aataattggg ccagaactcc cccaaccgtt ccaaaaaaga cggctcccaa
     1081 gtaaccgatt tgtcctttgt acactaaata tccagcgtag gacagaacga tttcactcgg
     1141 aataatttcg atcatgaggc ccagcataac accccaatat ccgagtccct ctaaaaacac
     1201 aagaatcgaa ctgataattt cggccatttc caccctacct tcctagtttc tctctccttg
     1261 taaacctgtt tgtctatcta taccaatcta cgaattgccg ttattattct atcacaaaag
     1321 aacctgctta ttccaataaa aagagcacgg ggtatttttg tacatgcttc caccaacccc
     1381 cgcatatatt ttgtacaaac tgaccaaagg ggttgttctc atgtttaaat cgttagttat
     1441 ccggaaagcc catcttgttg ctacagggtt tatcttgctt gtagttcttg cggccatcct
     1501 gtttttcaca aaaaaagata gcattgtatc cactattgct cctgccgggc aagaaagaac
     1561 ttttcagatg gtgacaacag agttcaagac aaccacgaaa gacggtaaac aaatagaagc
     1621 ttatcgctgg gacccgggaa caattgtcat aaaaaaagga gagaaggtta agctgaacat
     1681 atacggggtc aatggcgaaa cccatccttt tctcattgaa ggactgaata tcaagggaga
     1741 agtaaagaaa ggaaaagaaa ccgtagtttc ttttacggct gataagccgg gtacataccg
     1801 gattatctgt ctgacccatc ccgacatcgc ccatgaggga cctatggttg ggtatattga
     1861 ggtcttggat tagaattaaa tcgctaatag ttccctctct ctgtccctcg gcatattctg
     1921 taaggaaaag attagggcag gtgagagacc atgcagaagc ccagggaaaa gcacaatcag
     1981 ccattcccca ctcatcgtac tatacgtaga gcctgcagcc gtgagctgta caggacggta
     2041 aaaagactta aaaaaagaat acccaaggca aaaatgaagg aagccgaaaa tttttatata
     2101 aaaaaagttc tgctccattt gcctttcatc gtagaaaatg aacaaaaccg caaggagctt
     2161 gtggattggt gggatgagca cgtttcttct tttattgcgg agctatggga agtagaccgt
     2221 catgatctat cccgggcatt cagggatgcg ttcggcggct gatgcgaaga ggctgtccca
     2281 aaagcagaat tgtctgcttg aaggaccggc ctcttcttca ttctggttac acggaaggat
     2341 ggcacaatat gattttctta atccttaggg tcattctccc cttcattcag aaacaacagg
     2401 aatattggaa ttaaagcaac gaaacgggaa tatcagcttt ttaaacgggc ccgctccttt
     2461 ttatatggac gaatgaacag ccttccgttt accggataat ataggacaag cctgactaaa
     2521 ataggtcttg aaaaaagaaa atacccatgg taggatacaa ataacgaatt gaccaaaact
     2581 ctcatttggt catttggagg tgacactgtt gtctgtcgat cgtcgaaaga tgattgtcga
     2641 agcggcggct aaatcgtttg ccttcttcgg ctataaagcg actacgatgg atcaggtggc
     2701 caaacttgca aatgtgggga aagggacaat ctatacattt ttctccaata aggaagagtt
     2761 gttcggtgaa atcgtcaggc agcttaacaa agagctgatc tccgttgctg aacgggctat
     2821 tgacccgaat aaatcattcg tggagaatct gcacatcttc ctctatgcta tgctggactt
     2881 ccggcgtaag catgagttga caatccggct ttcgcatgag attgacgaaa tgggaacgat
     2941 ggcagccaaa gaaggaatgg aaaaggtcga agaagcgatg ctgtccattg tggccaagaa
     3001 agtgaaagaa gccgtggaca agggagaatt aaagccgtgt gatccggaaa aaaccgcctt
     3061 tgcaatgatg aaaatgtata tcgcttttgt tcatgactgg gatgcctatc atactgaacc
     3121 gcttgaaaaa aaagatcttg ccgaattatt tgaactttac ttcatggaag gattggctgt
     3181 tcggtagccg tcctttttta ccggcaaaga ttgactatat ggacaaaacg gtcagtaatt
     3241 cagaaaaatg tgacattttt cttttttctt tctatttgct tgtaaggccc aatcaacaca
     3301 cagataaaaa aggagtgaaa ccagcttgaa aaatgcaggg tttttcacaa aagaatgggc
     3361 ggccattttc aaaaacaaga aagtgcttgt ttccatctgt gccgtagcgc tgatccccct
     3421 gctttactcg tccatgtttt tatgggcatt ctgggatccc aacgaaaaat tgaatgagct
     3481 tcctgttgct gtagtcaata tggataaggg agctaatttc gaaggaaaag aacttcatgt
     3541 aggcgaggaa ttcgtaaata agattaaaga atccaaggat tttaaatggg acttcgtttc
     3601 ccaggaaaaa gctatccaag gaatggacga aaataaatac tacatgaccg tagtcattcc
     3661 tgacaacttt tccgaaaaag caacaaaagt attggatgat catcccactg cttcagatct
     3721 tatttacatt ccaaatgaga gcttaaactt cctttcttct caaattggtt caactgctat
     3781 tgaaaaaatg aaggcagcaa tttcaaaaaa tttaacaaaa gcttatgcgg aagccatgtt
     3841 taaaagtatt ggcaagatct cagacggctt tgttcaagcc gcagacggtt ccttacagct
     3901 caaggatggc tccatcaaga ttaaagacgg gatcgtccaa gtggatgata acctgctgaa
     3961 gatcaatgag ggaacgttaa ctctgaaaga tggggttacg aaaatacacg ataagttggg
     4021 ggaactcact aaaggagcat cccgcataca aaatgaagga acttccgtcg tagcagacgg
     4081 tgccggaaaa ttggccgatg cccaaaaaca gctctctgta caaggggcaa ataaaattca
     4141 gagcggttta gatgagctta aatcgggttc tgctgaatta agcgagaagc ttggtgagct
     4201 tgaaaaacaa cttaaagctt ctatgactga gatgaatgta cttcctgcta aagctaaaga
     4261 attaaatgat ggtgctcatc agttgtataa aggaacgcaa aacctttcaa caaattctga
     4321 aaaacttagc catggctcaa agaaaattca aagcagttta agtgaagttc tgaagaatca
     4381 tcctgagctg gcaaaagata ttaactttat gaccgctatg ggtgctacca aacaagttac
     4441 agatggaatg gatactctta ataagtctgt taataatctt ttgttaccag gggctaaggg
     4501 tatttcaggc ggaacagatt tactaatgag taaagtaaag gatattggaa aactggctca
     4561 attacctata ggcgtccaaa aacttcacga gggatcaact aaaataagca atggaattgc
     4621 ccaagcagta gtgggccaaa atgaattcgt gaagaacttc aatacattcg gccagaagct
     4681 gaatgaacta agtgccggtg ccaaacaggt ggacggcaaa atgaatgacc tgattgacgg
     4741 aagttctaaa ctgaaagatg gggcccatca attaggcggc ggtgttgaca agctgacaga
     4801 cggtacaaat cagatccgga cagagggaac agaaaaactg aatgaaggtg cggctgccct
     4861 ggttgaaggc cagactgaac tgaccgacaa gcttgcggaa gcggcggata aaaccgggga
     4921 tgtcaaaggt gatgacagca actacaacat gtttgcggaa ccggtaaaag tgacggaaga
     4981 aaaacgcgga cctgttccaa actatggtac cggattcgct ccttacttca tttcactcgg
     5041 actgtttgtc ggtgctctaa tgctaaccat tgtattcccg attaaaaatc cggtaacacc
     5101 accaaaatcc gctttcagct ggttcttgag caaattcggt tcgatgctgc tggtcggaac
     5161 agttcaagcc atactggttg atgccatctt gctgtacggc ttgaaaatcg aagttcaaaa
     5221 tgtcggatac ttcttcttct tcagtctgat aactagttgg gtattcatgg cgatcctgca
     5281 atttctggtt acggcattca atgatgctgg aagatttatt gccattattt tgttaatcct
     5341 gcaattaaca gcttctgccg gaactttccc gctggaattg attccgactc cattgcagaa
     5401 attcaacgcc ttcattccga tgacttactc ggtaagcgga tataaggctg taatctccag
     5461 cggagattac agtcaaatgt ggcatagtgt tcttgtactt ggatccgtga gcgtcgtatt
     5521 tgctctcctg acctatacag tgcttgccat tagtttcaaa aaacattatt ccaatcttcc
     5581 gggaaaccgt gaagaaagca taacagctta atacgatacc gaaaagtacg gggttttgat
     5641 aacccgtact tttgtatttt attaacatgt aaatgattca taagcataaa gacataaaat
     5701 cctttttatt catgataata ggttttagcc ttagtttcct gcttctgtcg ctggctatga
     5761 atactatccc tatggggacg gcttaactat ttggtaattc cgcccaggat tcataattgt
     5821 ttccgataac gttcatccta caaagtagtt atcatgaaca aaggagacct gtatatgcgc
     5881 cgcacttttg ttataactat actggcattg gtcttgtttt ccacagcttc tttccccgct
     5941 catgcgggct tttctgataa agacaaagag gtgaatatgt tatacggtcc ggttaaagga
     6001 agagattatt tcgaaccccg cggagatatc gtatgggaag tcccgatggg aaaaaaaatg
     6061 atggcactta cctttgatga cgggccggat cccgatgaaa ccgtgcaaat actggatttg
     6121 ctgaaacaat atgaggccaa ggcaactttt tttctgattg ggaaccgggt gatacgttat
     6181 cctgatttgg ttaaaagaga ggctagcgaa gggcacgaac ttgcgaatca tacgtatagt
     6241 cacgcgtact ttaacagagc ttccaaagaa cggatgataa aagaaattaa agatgcggaa
     6301 gaagccattt ttcaggcatc tggagttcat acttgcctat tccggccgcc aggaggatat
     6361 tataatcaaa ttcttgttga cgtatgcaag gccaataatt atacccctat tttatggtcc
     6421 tggcatcagg ataccgttga ctggaaaaca ccgggtgtca aaaaaatcgt gaataaagta
     6481 ctgaataatg ctcgtggagg cgacattgtc cttttccatg accacgtgga aggaagcaca
     6541 caaacgattg aagctctcaa acaaatatta cccgagttga aaaaacgggg atttcgtttc
     6601 gtgactgtat ccgaactgat ggggcagcgc aatttgaacc aggccaagcc tcttaataag
     6661 ccttaggcag atcaagggtt aacatatatg aaaaaattct tgatgttatt ccttttttta
     6721 ggctgttttt tctatttcca taccggggat ataaaggccg ggcaaaaaga aatgttactt
     6781 ccaagtcctc cctctctccc tccggggagc tctctttgga aatcgatccc ctttacaata
     6841 gactgtgggt attagttgac ggaaagcgga tcaaacaatt ccctgtagga cttggcaaac
     6901 agaagactcc gactccaatt ggcgaattca ctgtgatcaa taaatataaa aattggggtt
     6961 ccgggttcgg cacccgttgg atcgggctca atgttccttg ggggatatat ggcattcacg
     7021 ggactaacag accggattct ataggaaggc accaaagtca cggatgtata cgtatgtaca
     7081 accgaaatgt agagattttg tatgagtggg taaaaatcgg caccaaagtc accatctatg
     7141 gccatcctct gggacctccc tacgaggatc cccgccctct tgctgcggga gatagcggga
     7201 tcgatgtgca gcttattcaa taccgcctta aaagtgccgg atattttaac ggtatctgta
     7261 atggcaaatt tggcccgcag acagagctgg cccttaagcg gtttgaaaaa gatcacgatc
     7321 tgccgattga cggagtaatg ggaagacagg attatgaagc tttaggattg tgggaatgat
     7381 cgttttgggc cagcaagttc ttataatttt ctcgggagaa aagcagaaaa atatagatta
     7441 agctacaaat atcatttttt cactttgttt cgcaagcagc agtatacttc tccgtttgta
     7501 ttctttaaat tgatatgcct tattatatga aatcaccttc ttatcttttt caaaaaagcc
     7561 cgctttagca gcgggccttc ggctgacagg aaaaaatctc aggtaacctg aggatctgga
     7621 acgaatccgt gttgcaccac ccaaccttag ttgcattttt catcttattc attttttcaa
     7681 ttgcgtaata ccaaatagcc aatatcactt accagtttgc tctcagccgc ttttagcact
     7741 gaaacactta tttaagagta ttcaagattc cgccaaggat ggaagaggaa aagattgcag
     7801 aatcgcagtc gtaatttctt tagccataag cataactttg tgcagagaag ttgtttgcaa
     7861 aactgcatat tgccgcgggc cttcgctatt gacaatagct gcaatcgtaa aatccccaac
     7921 acacggcaaa tcctttccga gtgatttccc cggaaaaaga ggctggttgg aaacctgata
     7981 aagccccact gaagccgttc ttcccaggca agcatctata gctataacct tagagggata
     8041 aggaacctca ttaagccggt gatgaatgtt actggcatcg catggataag ccaaagtccc
     8101 gattacgaaa ggatatccgt gttcctccaa ataagtccct acaagcggtc ccaatgcatc
     8161 ccctgtggaa cggtctgtac caatacatac aaaaacagga agattgtccc caaagcttgg
     8221 tacgatttcg gataaatggg acgcaagttc ttcccctttt acttttttcc aatattcttt
     8281 agaagaaaca ggatgttccg cctgcatgag ctccctcctt tggtgttttt tcctattgtt
     8341 ccataagcac tccattctgt ctatagacaa aaacggatag gacaattctt ccagagcaaa
     8401 acaaaattta tgctaaaaac ggatcaggag gtctgctgtt ttacatggag tttacaaaaa
     8461 atttggctaa aatttaattc attggggtat aaaaacaata taggatatta attggatgat
     8521 tgggggtaga ctgatgacga gggaaaaggc aaaaccgttt atttatgcac ttggggcgat
     8581 ggttctcact ttttctttat tgtttgtcta taacttcatg gcaggtgcct aaactgaaaa
     8641 gaagagatta ttgcctctaa aaacggcagg tttccgttaa aatagcagcc agccggcttt
     8701 ttcagttaaa gaaaaagccg gctgttttat tatattcagg ctacgattgg gcagacaact
     8761 cgtccaaaat acgccggact ttgcttattt cttcagcgga aacaggagcg gatgaacctc
     8821 cggggcctct cacggcggaa ccgaagtgta cctgggtcac ccctgttccg gcaacaaaat
     8881 cagccaggcc ttcagctcta agtccgcttc ctgccaggat ggcaagatgc gtcttccggc
     8941 tcgcctgaac aagttccttt atccgatctg cagcatccat tacatttggc ttgcctcctg
     9001 atgtcagaat gcgtttgatt tggggatatt gggacagaat ctgcagtccg gagaactggt
     9061 cggacaattc atcaaaagca cggtggaagg tcacttccaa atccccggct gcatcaagca
     9121 ttctcttcaa agcttcctca tgaatatgcc cttcgggggt caaaactccc aggacgatac
     9181 ccgctttggg tgcaaagggc ttaagcttct gaatatccct gatcattgtt cgaatctcat
     9241 cctccccata cacgaaagac tggctgtggg gccggaccat aatttgtaca ggaatgtcta
     9301 ccgtttccaa aactccctca atcagaccaa gactgggtgt gagtcctcct tctttgatgc
     9361 ctgttattaa ttccagacgg tctgctccat gttgggctgc aattttggca tcagtaacac
     9421 ttatggcaat agcttcaaaa atcacgagtg ttctcctccc gtttgtttgt ctcataatga
     9481 tcatataccc attcagctct ccgggcaatt ccggtacatt cctttactaa attattctta
     9541 tttggaggtt aaaaatgatc catattcagg caaattcaca attctttcaa aactaattaa
     9601 tatccttggc agctcaagga ttaaacgatt atatttcatt tatactaaag caattatact
     9661 atacttacag tttacaagtg ttgacaatta atagattaat agatacattt ggttcgagga
     9721 atataattcc tacaattcta ataaacgggg tgtttacatt ggcaaatgat atctttgaac
     9781 tggatgtcca aattgagatg atgaacgagg aggagaactc caatcaagag gttggttaca
     9841 ccgggcactc taaaaactgg ttatctttct gtgtctcctg ctaagccgga agtaaattaa
     9901 atgtgaaccg aaacaccaaa ggaatgaatt cctttggtgt ttctctgcta tttatataga
     9961 ttgaatgatt aatgagcctg gacagaaggg atgataaaat ttgactttga ccagagaaat
    10021 tccagatcca catgcaaaac cgggtcaaga taaaaattta ttccaaccgc ttcctttttt
    10081 catggtacgg actccgctat tatctataga aaaatataaa caactaactg aatccgggaa
    10141 gccggggata cttggacccc tgattgacca gtcacacgat cctgttgtac gggaagcaat
    10201 tgccgtcgcc agcctgtctt tgcttgattc tttgcccaac ttaacaaata tggatcaacc
    10261 acggaaacag gatcaggcta ttaaagggtt tttacggtat atgttaagga tgacgacgag
    10321 accgacacct tatggtctat gttctgccgt aggttttgga aggtttggga ataaggcaaa
    10381 tgtggccatg ggagaagttt ctggccacca gaagcaatcc aggccggata tgagctggtt
    10441 aatgcaaatg gtacgaaaat tggaggccga tttagacctg gtattacaat tgcgggttcg
    10501 ttcaaattca atggtttatt tcactggttc acgagcaaag ctgccgtatg tgacccgata
    10561 tggacaacgg gaaattgaaa cgatgtcaca aatggaaagt gcctctatcc gattaacccc
    10621 tgtagttcaa ttcgtattac aggaggctga acgtcctgtt ctattctgtg aattggccga
    10681 ccgggttaag cagaaatatc cggatactcc tgatgagaaa attatcagat ttctatggca
    10741 gatgtttcag caggaatttt taataagcga actgcggccg ccattaatga ttgagtcacc
    10801 ttttgattat ctgcgggaac gtcttgcgaa tattaaagga atcgacgaag aaaaacaaag
    10861 tctgcaggct attgccgagc agctggatgc ttatgacagg ttggaaattg gagagggtga
    10921 ggctgtttac cggaaactgg tggcacaaat gagaagcttg gcagatgcga aaaatccgat
    10981 ccaggttgac ctctcgctta acaagcaggc tgccgagctt ccgcatggga tcggagaaga
    11041 agtcgccaag gcggctgaag tcctttggtt gctgagtgta aagacagtag acgaagcgaa
    11101 cctggaggcg tatcgggaag aatttacaga acgttacggc ctccagcggg aagtgcctct
    11161 actagaatta cttgacccgg atcttggact gggtgctcca gccggatatg agtatcctcc
    11221 aagcagacgc aggcaggaaa taatagcagc aaacagccag cttgatgctc ttttattact
    11281 ctggatgaca caggcgctgc atcgtggcga gatagaagta gaactgactg aagaccatat
    11341 tcagcagctt gtacatgtga ctccggataa tcccaaagag gcaccaatgt cattggagct
    11401 ttattttaca atagcatctc ctgacaagtc gtcgctagag caaggtaact atcgcctgat
    11461 actcggtcca aatccgggat cgcaaggagc gggcaaaacc tttggaagat tcgtccggtt
    11521 tatgaccgaa caagagcata cgtctctggc agaaattcag aaatatgaac agtcgctgca
    11581 tccagatgcg gtatttgcgg aagtggttta tcttccgaac gccggacgtg ccgcaaatgt
    11641 tgcactttca acgaatataa ggccttatga ggtagtaatg ggcaccaatc catctgaagg
    11701 ggaaaagatc tctttgcctc taactgattt aatggtaggc agtacgatgg atcattttta
    11761 tttaaaatcc aagtcattgg gccaagaagt cattccggtg actttacata tgctaaattt
    11821 tatgcacact cctaacgtct accgcttttt gcgagagttg tccatcatgc gtacatgcaa
    11881 ttggaaaccc tttacctggg gaacctcata ttcgcctacg ttttcacggt aattcggaac
    11941 atctgactgc tgaacttctt ccggaggtat accgatgggc gctttacctg cagcaggaag
    12001 gtctcctaac tcgtctagtg gtggatactt atgaaccgga gatcgaacgc tatggcggtc
    12061 ctgcgttgat agggcttgcc gaatcggttt ttgcaaccga tagccagacg accgcactgt
    12121 ggctcgggtt aaaaaggacc ggacaaatcg ggctgtcaat ggagatgatt ggaacaatca
    12181 gcgtaatcga cattatggaa caattcaacg tgccgttcgc cgatcaatta aagttacttg
    12241 acagcatggc gtttcgaaaa gaataccttg aggagttcag aaaagaacgc cgcctgtacc
    12301 tgagtctcgg ggattcgttt catgattggg agaatctctt gaaacaccgt gacggaaaaa
    12361 tactttatga ggggatgaaa gcccgccgcc atgctctgcg gcaataccag aaggcggtaa
    12421 gggaccaaga ggaagacgga ttgctttaca acagcttcta taatatcctg tccagtatga
    12481 tccacctgca cttgaaccgg ctgcttggca ttgaccgccg tcgtgaaaaa aaggttctta
    12541 cgttggcact tcatacacta tataatctgc agtacatacg cgggaatcgg aaagcgaagg
    12601 agaatgaaat acatgaataa tgcaaagtct tggcaaccaa ttcattcact cgagttacag
    12661 catgccattg aaagttgtgc acgggatgtt gccggaaggt tgtcggaacc ttcattggta
    12721 cgtgagttgt ccaagactgc acaggaaaga ttcggtcgtc ctggtcctgt atggtccgat
    12781 ttggatcttg cgactggtta tccgggtctg tgcatattat tcggtgagtt ggaccggtta
    12841 tttccgggtg aagattggga cgtgatcgga cactcccatt tggtagagtt acagtgtata
    12901 atacaagcac aaaaattgtc ttcgctctca ctatggggag gtttgtcagg catagccata
    12961 gcggttcggg cattatcccg cggcggtatc cgctatcagg gtttcataca aacgttgcag
    13021 ggagttttcc tgcgtcatta tcagcggaat ctcagtcaag ctatgcttca tttagagaac
    13081 ggtgtgcata tgggcgatta tgatgttttt gaagggttca ccggaattgg acgatactta
    13141 ttagcctttg ctgagcaacc ggaattaagg aaagtactgt gcgaggtttt aacatatttg
    13201 gtacgcttaa gtgaaaataa gaccgtagac ggacaatcag ttcccggttg gcacatcccg
    13261 gcctcgcatc tggttttgcc gcaggagaag atcgactttc cttccggtaa ctataattgt
    13321 ggagttgctc atggcattcc cggaccactg gccttacttt cgctatctct atccgcgggt
    13381 gtggaagttc ccggacagag ccaagctatc cgaaggattg ccgaatggtt attggagtgg
    13441 aaacaagaag acaggtatgg cccgttttgg ccgcaacggg ttgcctggga ggagcagcag
    13501 acgggacttg gcggatcggg ttggcagcgt gaagcctggt gctatgggag cccgggagtt
    13561 gcccgtacac tttggctggc aggtaaggca cttgatgaat ccggctggaa gcaaacctcc
    13621 cttgaaacat ttatcgcatt agcccaccgt cctgaagagg attggaactt acatgcacca
    13681 acactctgcc acggttttgg cggtctgctc cagatgacgc agcgcatgta tgcagaaagc
    13741 ggggatgatc aactaaatgt tgttcgggaa cgtttagcgt ggcgtatttt ggaatcgttt
    13801 gaccggaata ctccctttgg ctttagcgaa gtaattaaga cagagcatga aacatctgta
    13861 ttgcatagtc ccgggttatt acaaggggct gcaggaacgg ttctcgcact tcttggactt
    13921 tgcagtacac aagaaccgga gtgggatcaa gttttactga tcacgtaatt ttctatcaaa
    13981 gtgtttatag cccggactct tcagatcaag aaattttgac tggtaagctt ttgttttaaa
    14041 tgaaggattt ggtatggcgt ataagaccag ttatataatc ggtctatggt tcaatcctgc
    14101 ttcttcttat tctggctgag accgtcatcc gaacgattta aaaaaacccg gagatgagtt
    14161 cggaaaccgg taaaccccca acccgaaact ccggcacatt ctccatggaa aaaaaccaga
    14221 gccgaatagc tctggttttt aaatgcggat ttgatcagga agggttcaat tgaagcgtat
    14281 catcttcccg gttaaacgcc tcgcggtcaa attctccttc gctctcccct acaataaggg
    14341 ccgcaacggt tgtaccggtg acgttgacgg ctgtccgggc catatccacg attgcatcaa
    14401 tccccataac aagggcaatt cctgcaacgg gaagaccagc actcgacaag acaacagtag
    14461 ccataatgga ggctgttccc ggaactcctg ctgtacctac cgaagccagg acagaggtaa
    14521 gaacaataag caggtaactc gtaaacgtaa gatcaatacc atatagttta gcaatgaaaa
    14581 tacagacaat tgcagggtac aagccaccgc atccattcat attgatggtg gcaccaagcg
    14641 gagccacgaa gctgacaatc ctttcggaga ttttaaccct ttccgttaaa gtcttcatcg
    14701 taaccggcag agtgccgtag ctgcttcttg ttgtaaaacc gaccaccata accggaaaaa
    14761 tcttgcggaa gaatctcagc gggttcactt tagcggccag gccgacaaaa ccggtatacg
    14821 taatgaccgt atgaagaatg caggccacgt agaccgccaa aataaacttc ccaagctcta
    14881 acagggttcc aagtccgtat tttgaggcca tagccgtcag aaggccgaaa acgccgtaag
    14941 gtgtcagctt cagtaccatt tttgtcacac ggaacatgac ttgcgtaaag gaattaacta
    15001 cgtcctttac aggcttcata gtttccggtt tacgttcact ttcaatggta atcgctaccc
    15061 cgatgatcat ggcaaaaata atgactggaa taatcttacc tgcggacatc tcggccacag
    15121 ggtttttcgg tatcatatcc aaaaggaacg cggtgaaatt aacttcacgc actttgtatc
    15181 cggaagtatc cgctatgctg atgcctgaac ccggatcaaa taccaaaccg accagaatgc
    15241 cgattacact ggcgatagcc gtaagaagca ggaataaacc aattgttttt actcctacgg
    15301 tttttagctg ttttatatcc gtcagagaag tcatacttga aataatagag gaaataacta
    15361 aaggaataac cagcatcatg atcagattaa tataaatgct tccgagtacc ccaatgcttt
    15421 gtgcctggtt tccaaagatt ataccaaccg caacccccag tgccatggca ataaggacac
    15481 ggataccaaa gctgattttt ttctttttca aaaagtacaa gaatcctata agaatggctg
    15541 ttacaatcca gcttgtataa gtcaaattca ttgtacctcc acctcccaaa tctaatgata
    15601 tattttattc tttctataaa ctcttaattc ccattggttt aatcggtatt tagattactc
    15661 cctttcacta ccgttgtcaa caaaagattt tagaaaatga tcttcctgtt ttccccataa
    15721 actaacaaaa gcactcccct gtctttatac agaagagcgc ttaagctata gacaaagtct
    15781 ttgtttatta ccattagatt ccgaaggctg tatccgtgct ttcttcatct tcatagtcgt
    15841 aagcttcctt atcaaaacct tacagtccgt gtttcatgct gccaaaatat ttatccagtt
    15901 catcgctttt gatgatatcg gctttgcttg gatcgatcgt tattttgact tcttgattca
    15961 tcttggaata agcagaattt aaagccagct caataccgaa agtttcaccg tctgctttag
    16021 cttcaatacc aacgtttaga tccattgtaa caaaattatc gtctttatcc agacccgcta
    16081 ccagagaagt gtttttaaaa gtagcttcat tcatggactt tttcaattca tccagatctt
    16141 tttgggaagc ttcctggcca agtcccttgg aggtgctggt cagaatgtta gtgatcagtt
    16201 ctttcaggcc ggcatcatca acttccgcct tatatttgtt cttgatattt ttgtctttgt
    16261 cttctttggt tacttcctgt tccgtcaatt tgattttttt gtctttgacg gctttcagca
    16321 gttcctcttg ggccgctttt tggattttgg cgacttcctc cggtttcaag ttctggctgc
    16381 tcgaatcttt tgtatcgatt tcaagcaatt tgcccttgat ttgaggaggc aggaacatgc
    16441 tgaagttttc gtacagatta tctgtctgca catacacttt ctcattttgt tcatctacca
    16501 ggactggcag cttgatatcg aagctgacag gcggaacttt tatacttgca ctgattgtgg
    16561 actcgctctg tttcttttta ttatctacaa cagaagccac ttggatttta gcatcattaa
    16621 gtgctttaac agccgcttca gtctgaggat cttctttagc tttgtcagga gcattaattt
    16681 tcagttttac ggttgattca gattcgtaac tgcttactgc cttcagttga tcgaacgcct
    16741 ttaccagatg atcgttcgga tcctctttcc ccccacatgc tgccaacatc aggacccaag
    16801 ccccacatac aagggaaagg aataacttat tccagccttt catgttgtca ctcctttttc
    16861 tatatattta ataaaaataa aaaacagcaa aaatgaactt aacatggaaa aaagaaacag
    16921 tcaattgttc ccagatgttc agaaaacgct ttcttccatt gcatgaagga atgttcacaa
    16981 aatagacaca aaattcacag gaatgcaata agaaggaaaa atcaattaaa agggtgcctt
    17041 taccattaag tcataaagca aaccggctaa aattgcaata aacagaatat tacgtaccca
    17101 atcaagtatc tgattatgag ggaaaataat gggcagtaca aggaaaacaa tggcgaagat
    17161 caaaacaacg gcaaggttca accttgacct ttatttgata ttgattttat ttaaccatct
    17221 gtaaattgtt gtgtttctat tgggatccag tgaataccat tcgatggtgt ccacattttg
    17281 aatgagttca gcatgctcat aactattgat taggtgctcc tcgtggtagg ctgaaataac
    17341 ttctcgctct atagcaaatc cttccaataa ctggttcatg tattttagct gaatcccaac
    17401 caattgtgag ctgagaaaac gacctttcat caattgttta ttaatatcta tcctctcttc
    17461 cagcaaatta cgaaagacaa aatattcgtt ggcacttaat gaatcattat cttccatttt
    17521 ctttattttt tttgtgttgt aactaaaaat aaattttatt tctttaaaca aatcctcgct
    17581 ggtctgagtc aactgttccc cccttcccaa ccatttcttt aatataataa aaattagttt
    17641 gcctgaatac tttatcttaa cccacttgtc tttgtataaa aatgtgttaa tgatatttaa
    17701 gatcttttga tacctagaaa aagctgggta gctgattttg tttgccttat agagtttcat
    17761 tagtccttcc atttcaattt tcatcatttg tttgcggact tttcggagaa ttttgggaaa
    17821 tttccctaaa gcatattctt ctataacttc ttctttacgt tttctgtatt tactaattac
    17881 catatcgtac tcagattttt tatcactgtt tctacgcagc ttatacagtt gttttatcac
    17941 cttatcatat atttcgataa ctaaaggagt aaggtccttt tgattaattt taggcgatat
    18001 tattggaatc atgatacttc cgataaccat ggaaagtaga attacacaca tagtaataaa
    18061 aataatcaga tctctttgtt cgaagtaatt tccagagttt aaataaacgg gtaatgataa
    18121 aattgctgct aaactcacgg ttccttttac tccagcaaat gtaatgatta aatgattctt
    18181 gagggaatag ctattattat cttttattac tttcggcatc agtacaccaa taaatacaaa
    18241 acgaatcaaa aaaattaaaa tcgtaatgga aataactacg attgccaaca aagtcaactg
    18301 agtctcaagg atttccctta tatttttaat cgctgaagga agttgtgcac ctaaaaaaag
    18361 aaatacaaat gcattaagta ttgtaagtat tacttcccaa attgattggg agatagtact
    18421 tctttctgcc tcagcttggg aaattcgttt aaattcaaat gcaaacataa tcccagcaga
    18481 tactgcagcg ataatccctg aaaaatgaaa taactcagct actatataac tgataatggg
    18541 aagaattaat tcaaatatga gatgtatttg aatatctgct cttcgatgca acttaaaaac
    18601 agaaataata cgatttttaa caaaaacgat accgacgccg actatgatcc ccctagagtt
    18661 gatatgatta actgtgaaat aagtccggta gcagagtaac tcccgtaaag caatgccatc
    18721 acagctgttt gaagcagaat aagccctgaa gcatcattaa aaagcccttc attttctagt
    18781 aaatgcaatg tttttccagg aattttcact gttttggaaa tggaaacgac agaaaccgca
    18841 tctgtaggac caagtgctgc cgccatagca aaacaagcgg caagcggtat agctgggagc
    18901 agccagtgta tatatggacc taatacaagg acacttagaa taactaaaat aaatgataac
    18961 aggagaatgt tagttttgct tttccatatg gattccagat ctacattttt cccttcatta
    19021 aaaagaagtg gagcaacaat aaggattaaa aatatttccg gctcaaattg gaatttatca
    19081 aagcttggaa aaaggcctat taaaatgcct agaccaactt gtaagatggg cattggaaat
    19141 aaaggaaaat atcttttaca aataagtgag cagatagttg caagaaaaaa aacaaaaaaa
    19201 aacgaaatca tttccatata gccccaaacc tttctttata ataattgtta gactagttac
    19261 cttacgattc tgggagccgt tgtaattctg ttcaccctgg atgttcccat gactttggtt
    19321 ctgctgattt ccgttcctat tattctctta attatggtcc cgataggaag gaaactatat
    19381 aaaatttcag taatcagccc taacggcatc agcacggatt caattttcgc tttttgaata
    19441 ccgaatgagt acagcgaatc aatttccttt ttcccggtgg agaattcact tttctctgtt
    19501 gtataggctt tggtcagccg gatttccatg agcatttgga taaaaatgcg gtcagctgcg
    19561 acattttttt ctgctggtgg gctccattgg cagatttatg accagcatcc agtcggccaa
    19621 aggggcaacc gaacccttat gcagattctg gacgagcctg aggagaaata tgagagcgga
    19681 aaaccaaaac cggatggaga tactttatct tttcatcaag tcagttttgg ctacggtcaa
    19741 gacaaacccg ttttgtcgga tatctcgttc acggcacaac cgggtacggt taccgctttt
    19801 gtcgggccga gcggggccgg caaaacaacc atcttctccc tgattgagag gttttataaa
    19861 ccggactccg gcacaatttc gctgggggca aaccagcgga ttgccattgc ccgggccttg
    19921 ctgaggaacc cgcagttcct tctgctcgat gaggccacag ccagcctgga ctctgagtcc
    19981 gagcggattg tacaggaagc tttggatacc cttcttgaag gaaggacttc tttcgtcatc
    20041 gcccacagac tttcaacggt tgtacacgcc gaccagattc tggttgtaca ggatgggcgg
    20101 ataacaggaa ccgggaccca tcaagaattg atggatagcc atcctttcta ccacaaactc
    20161 gtggaacagc agttccagag ccagagcctt cccctgttag agaaatatta aaaatgaaaa
    20221 gaaaagtccg tcaagattgg gtcagacttt cctttttcag tttcactcat ccctcagaca
    20281 aataatccgt cgtaggccca ggtaggtttt ccggtcactt tcctagactc aggcatctat
    20341 ataagtaata gcctggctgc ccatctgtat ccatgaatca aggaaatctt tacggtctaa
    20401 ttttttggag gccgtaccat cgagaggatc attgacgtac acgttatcct cgtcatatcc
    20461 aaccagcaat accgcgtgct cggagaaggt cgctttgacc gggctgtttt tactgttcca
    20521 ggttacccaa ttcccaacgg aggcaaaggt tacattggtc cagaccacta caggctgccc
    20581 ttcggatata gactgcagaa cacgatcaaa cgattccccc gtcaaatcta ctgcccttcc
    20641 cggaagaata gattctacca gatcgtaaac cggcccatga taaacactga atcctatacg
    20701 ttcacctgta acatctccca caaatccctc gtttgggtcc cccatgagag aatgtttcca
    20761 ttttcatccc tgcggatcgg ggaggaatcc ttggcaacct gcttggccag cgtcatttta
    20821 tcaaccgggt gcccggccgc cttcagcatc atcgcgacac tagtaatctc gcaaccgtta
    20881 taaagctccg gattttgaga aataatagga acggccagca gtttttcggc cggaagaggt
    20941 tccggcgtct gcataggttc cggggtagag gaaggaatgg aagtttcctc tacagacagg
    21001 ttcttttcca ttgctgcttc cttacgcgcc tttattgctt ttcccagagc gttattgaaa
    21061 ccaggccaaa tcataatgat ccctattaag gctataagga catacatcca actcttcttt
    21121 ttcatagagt gctcctttat aaggtaggaa tattccaaaa atacttaagt actaaataat
    21181 attttagcac aaaaataagt gcttttcgag catatttccc ctattaccgg actatgaaac
    21241 cgtttgatct gcaaaggttc atttcctaat ttggtgaaat ctgttttgag atgctccgcc
    21301 ttgtggtaga ctgatggtag aacttgaaaa gaggataagg ttatgtacat catcaacttc
    21361 tttgtttctt cattgccttt tgtcacctta ttaaatatac tgcttgccat caccatcatt
    21421 ttcctggaac ggaggaatgc ggccaccacc tgggcctggc tgctcatttt atttttcatt
    21481 ccggttttgg gatttatttt gtatatcttt tttggacaaa atctgagcag gcgcaggatc
    21541 tttaacctga acaccgaact gacggcgcaa ttgcgcaaag agatcaaggg acagaaggaa
    21601 ctcctggata gaaattcatt tcagtttaac catcctaccc ttcaagagta ccggtccacc
    21661 atctatctga atttgattaa cggctacggt gtattaaccc aggataacgg agtagagatt
    21721 tatacggatg gagccgctaa attcaaagct ctctttgaga aaatccggga agcgaaagac
    21781 cacatccata tgcagtattt tatttttaaa aatgacgttc tggggaaaaa ggtagttcag
    21841 gcgctggccg aaaaagcgcg ggaaggtgtg gaagtaaggc ttctctacga cgcaatgggc
    21901 tcctcccgtg tacccgggcg gttcttcaag ccattgaggg aagcgggcgg gaaagtagca
    21961 gccttctttc cttcgctttt ttttccgttt atcaattacc gtatcaacta ccgtaaccac
    22021 cggaagattg ttgtcatcga tggagaatat ggttttgtag gaggatataa tgtcgggaaa
    22081 gaatatatcg gactcaagaa gaagttcggt ttttggcggg atacccatct gctgattcac
    22141 ggaagtgcag tcgaatcatt acagtcacgt tttttccttg attggaacaa tgcttcttcc
    22201 gataaactgg agtttgatct ccgttatttc ccggaaaaaa cctataccgg aaatataccg
    22261 atacagattg tttccagcgg tccggattcc gaatgggagc agattaagaa cgggatcatc
    22321 aagatgattt attccgcaga aaaaagcgtc tacatccaga ccccctactt tgtcccggac
    22381 gaaagcctga tgcacgccct gcggatcgcc gcgttatccg gaattgatgt gcgcatcatg
    22441 attcccaatc agcctgatca catctttgtc tactgggctt ctttctcctt tattggcgaa
    22501 ctattggata tcggggtcaa atgctttatt tacgaaaatg gcttcatcca tgccaaaatg
    22561 ctggttgtgg acggcaaagt ggcttctgtc ggcacaacca acttcgacat ccgcagtttc
    22621 aagctgaact ttgaagtcaa tgcgttcatt tatgatacca atgtggcagg acagctttac
    22681 tccatctatg agcgggacct tctgaaaagc agggaaatga cctatgaaat gtaccgcaac
    22741 cgttctctca ttattaaatt caaggagtcg atttcccgtc tgctggcgcc aatactataa
    22801 aaggtgcagc gaaaccggtg ataaatttgt accggaagtg aaccggtccg ttatatgaaa
    22861 tcaaaaaaga ccttcctttc atctatgaac tgtgacccgc aagagggtca cttttttcaa
    22921 aatgtccttt ttacgggtca cagttcagtg tatggaaggt tgggttctat tattatgcag
    22981 tatccctaat ttttggattt gcggtaaccg gctgcctggg cttccttctc agaacagaac
    23041 atgaccacgt ttttcttcgt tttattataa tgcgctcctc caggtacgtg gtaaatcatg
    23101 gagttccggt tccctttaat agtagggttg gaacaggatg cactcccttc ggaagtagaa
    23161 ggagagggtt taggcgcaga ctgtgatgcc tcctttttgg gggaagtctg cccggacggt
    23221 tttgtttctg gcttggcctg ctctttcttc gccggttgtt cctttaccgc ctggggttcc
    23281 ggttcttttg ccgcagttag aatttcataa ttatacccgc ttgccgtcac aaaattcgca
    23341 attccccaga ttccgtgtga actgcttttt gctgtttcct cagtcctttt taaatcttct
    23401 atatacttgg catcggacgg ataatccgtc attcgggcca acccttggtc gagcagcatt
    23461 tgattaaaga gattttcgcc aagatgtata aaagcgagcc tacgtccctg actatccttt
    23521 tgatcgttaa cgaattcaat ctgtacatcc tgatccagca gcttttgtct tgcaaaatcc
    23581 agtgcctcag ttgccagcgg agtatctgac agcccttcct tctgctcagg tgtttccaca
    23641 aggtaaagtc ttactttctc ctcttttcca tctatttgaa ccaccggaga gtttacatcg
    23701 gaaacattta ctactttcgc agccagccgt tcgggaatag gcgtcggctg aacggataca
    23761 gtcggggatg gactcggctc tggtgccgag ggagttggaa cgggtgcagc ctgtctgggc
    23821 tgttcaggag cgtttatcat tcctccccat atgattagaa caaatacagc aaatcctaaa
    23881 ggaacataat gcctttttgt tttatccgct tcccctttat atttccggta cagactaaaa
    23941 ctccaatagc ctagcgcaca agcaagaa
//
