LOCUS       NZ_CP020555            10486 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces sp. Sge12 chromosome, complete genome.
ACCESSION   NZ_CP020555
VERSION     NZ_CP020555.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. Sge12
  ORGANISM  Streptomyces sp. Sge12
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7983613)
  AUTHORS   Tao,M., Xu,J., Xu,M., Liu,K., Zhao,Z. and Peng,Q.
  TITLE     Genome sequence of Streptomyces sp. Sge12, producing unknown
            compounds against rice blast disease
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7983613)
  AUTHORS   Tao,M., Xu,J., Xu,M., Liu,K., Zhao,Z. and Peng,Q.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2017) School of Life Sciences and Biotechnology,
            Shanghai Jiao Tong University, Huashan Road 1954, Shanghai 200030,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: RS_HGAP Assembly v. 3; BWA v. 0.7.10; Bowtie v. 2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 85.0x
            Sequencing Technology :: Illumina HiSeq 4000; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 03:12:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,312
            CDSs (total)                      :: 7,216
            Genes (coding)                    :: 7,106
            CDSs (with protein)               :: 7,106
            Genes (RNA)                       :: 96
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 111
            CDSs (without protein)            :: 110
            Pseudo Genes (ambiguous residues) :: 0 of 111
            Pseudo Genes (frameshifted)       :: 32 of 111
            Pseudo Genes (incomplete)         :: 91 of 111
            Pseudo Genes (internal stop)      :: 8 of 111
            Pseudo Genes (multiple problems)  :: 18 of 111
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:35:20
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7611424
            Orig. end                         :: 7621910
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP020555.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10486
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="39"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10486
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10486
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5486](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5486
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(729..738)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     misc_feature    1323..1341
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.07"
                     /tool="antismash"
     misc_feature    complement(1328..1337)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.85"
                     /tool="antismash"
     misc_feature    complement(1387..1400)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.18"
                     /tool="antismash"
     misc_feature    complement(1392..1406)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.78"
                     /tool="antismash"
     misc_feature    complement(1649..1664)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     gene            1684..1845
                     /locus_tag="B6R96_RS37460"
     CDS             1684..1845
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B6R96_RS37460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_159396418.1"
                     /transl_table=11
                     /translation="MDQSSSTLRSMRAGPGPAVEPARAAGPYAFTSEERHMNPTSRATG
                     TVRAADAA"
     gene            1899..2603
                     /locus_tag="B6R96_RS34125"
                     /old_locus_tag="B6R96_34125"
     CDS             1899..2603
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006344589.1"
                     /locus_tag="B6R96_RS34125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B6R96_34125"
                     /product="DUF1345 domain-containing protein"
                     /protein_id="WP_081524667.1"
                     /transl_table=11
                     /translation="MTGREPAETDRTSAREPGPRLTVRTESRWPLAAAVVASAVLTLLL
                     PDDLRLGPRWALPVAEGLLLVALISGDPGRISRRSTVLRSVAIALVVVLVGSAIWSTVQ
                     LIDDLIHGGSETNSANALLLAGGSVWASTVLAFSLLYFELDSGGPAARAHHMPPTPALD
                     FPQQLSPELNAPHWRPHYIDYLYLGFTNSTALSPTDVMPLAPWAKSVMTLQSILSLMIL
                     GLVVARAVNVLA"
     gene            complement(2631..2867)
                     /locus_tag="B6R96_RS37465"
     CDS             complement(2631..2867)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B6R96_RS37465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_159396419.1"
                     /transl_table=11
                     /translation="MEGVRTGLAAWLVREAPARLRACGAPAELRDAVRLLGLAHADRWD
                     GPAGTAPPLRLTRPPRPTPPPTAHGPRPLLRQR"
     gene            complement(2978..3643)
                     /locus_tag="B6R96_RS34135"
                     /old_locus_tag="B6R96_34135"
     CDS             complement(2978..3643)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B6R96_RS34135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B6R96_34135"
                     /product="hypothetical protein"
                     /protein_id="WP_081524669.1"
                     /transl_table=11
                     /translation="MAGWHGGWVRGIRRTAVALAAPPLTAALAFGVARQSAYGSLGNWG
                     FFLGGVLLPLVLLGWHAAVAARREASLIALSALPAALGAILALASVGHSTLEDRGVEIS
                     CVVLKVTERTETETSMDAEGHWTSTTRTSYDHRLDCPAGGPEYLNTPSRLAKEGESLAV
                     VHDPQGKVSPRAAGDVHGRGMRTAAAVAVGTAVLLGLAGGIREAYEKRRRSPRRPTGR"
     gene            complement(3959..4534)
                     /locus_tag="B6R96_RS34140"
                     /old_locus_tag="B6R96_34140"
     CDS             complement(3959..4534)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B6R96_RS34140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B6R96_34140"
                     /product="hypothetical protein"
                     /protein_id="WP_159396420.1"
                     /transl_table=11
                     /translation="MNALLKRVWIGLAATLIVSLAAVVLPDQIQINDDGRIHLGAPAPS
                     PSTAAPAPESTSPPLTRDAVDEAIRTAVSAAGLDPAQGRPIGAAGADSNKTGWMAVREQ
                     TAAQSDMNAICADLERQGWTLNPNGDRPEASRSYKRGGWYLLVSTRGKTQAPSTTSALT
                     DSQTYLTVTGLQLNLSDLPLPEITVRIG"
     misc_feature    complement(4825..4839)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.61"
                     /tool="antismash"
     misc_feature    4870..4884
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.42"
                     /tool="antismash"
     gene            5001..5486
                     /locus_tag="B6R96_RS34145"
                     /old_locus_tag="B6R96_34145"
     CDS             5001..5486
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003950154.1"
                     /locus_tag="B6R96_RS34145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B6R96_34145"
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="WP_053703615.1"
                     /sec_met_domain="Lactococcin_972 (E-value: 8e-07, bitscore:
                     28.3, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIAGRSIAFAIAGAAIAAVGLATPATADASAAASASGATVTVHH
                     RGDGTQPPAELGNPSEWGVVTFKMDAAAASFGAQSQACISPSTGGNWCYGWYAREVSPG
                     VINKYCYSNYYQNTKGHSSTVKLAGSTRRVWAAAGNTSNANLTAGLAYTCSTYYSVD"
     gene            5686..6297
                     /locus_tag="B6R96_RS34150"
                     /old_locus_tag="B6R96_34150"
     CDS             5686..6297
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712128.1"
                     /locus_tag="B6R96_RS34150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B6R96_34150"
                     /product="hypothetical protein"
                     /protein_id="WP_237291600.1"
                     /transl_table=11
                     /translation="MLLGLVGPVAGKWDNPVCVATGIVFSSGWPWACYAFLVGYSRRPK
                     IESALLASVGLTIGVVTYYIFKDMNPIIPAGMESAPSVPAGMELESGASSGGQILVWGI
                     AAFVFGAPVGLMGNVARTPGIGGLLFRLLVPFIAFFEATQRLNVEADSQGPVFDMTWNA
                     TRVAACVVAVALVAHTVWNWRVRRGRADGRAEAVAPERRL"
     misc_feature    5712..5728
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.58"
                     /tool="antismash"
     gene            6678..6854
                     /locus_tag="B6R96_RS38865"
     CDS             6678..6854
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B6R96_RS38865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_335755561.1"
                     /transl_table=11
                     /translation="MLGGAVGDRFGARLVMITGDVVMLTVTLVLALVGPDSGASPWLLV
                     LVAVVIAQEAALV"
     gene            7056..8528
                     /locus_tag="B6R96_RS34155"
                     /old_locus_tag="B6R96_34155"
     CDS             7056..8528
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004931011.1"
                     /locus_tag="B6R96_RS34155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B6R96_34155"
                     /product="hypothetical protein"
                     /protein_id="WP_081524672.1"
                     /transl_table=11
                     /translation="MSDAIPPPVHLDGVVDGLAENPSLPSELVRRLLGHRTGFGEVAKR
                     PDLSDDVIAEIIAMDDHWLTHSLALNRRLPQAFRMMLAEHPDPAIRRALAVAADGAPRG
                     LFERLLGDADPQVREHLAESDHVPADLRARLAADENPKVRATLAQWWTTAPEPVRRTLL
                     TDPDDSVRAAACATYFRRIPHPVPPVDLVPELLADPVTRAGAVRHCTLDTAAARRLAED
                     PDDDVRAELAEHPDLSPELRDKLAEDPNQRVALRIFARQDTPEPTRAAIHARILSEVPP
                     LDWLEDHEALDDDALEREILGELARAELRTLRLPWVTTDPLPYVDSPYVCFRASAAMSE
                     QLPPPLVARLLDDEESSVRTAMALHARDRIDPDTAERIDRTFRPDKVVRWRPADDFPLP
                     ADVLRRLATDADPRMRQLAPRDPDLPVELARRLAADPDHMVRRTIAAHPRLPAEELTRL
                     LADPAESVAATAAANPNLPTTGMYQLIALAGL"
     gene            complement(8638..9051)
                     /locus_tag="B6R96_RS34160"
                     /old_locus_tag="B6R96_34160"
     CDS             complement(8638..9051)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B6R96_RS34160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B6R96_34160"
                     /product="hypothetical protein"
                     /protein_id="WP_159396421.1"
                     /transl_table=11
                     /translation="MSKKTRAAVWTSVALGLIAGGTWAGTAVAAPPGSAKVTAPYAQAA
                     AVVNANGSVNRSKGIEAVTKPAAGHYCVELEDKDLDIRKLVPNATLQYISFEYDIRISM
                     WPHPSCGTRTDTFLVITGKPGVYEDASFSIVVP"
     gene            9569..10111
                     /locus_tag="B6R96_RS34165"
                     /old_locus_tag="B6R96_34165"
     CDS             9569..10111
                     /NRPS_PKS="Domain: PKS_KR (14-128). E-value: 3e-15. Score:
                     48.5. Matches aSDomain:
                     nrpspksdomains_B6R96_RS34165_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012334.4"
                     /locus_tag="B6R96_RS34165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B6R96_34165"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_237291601.1"
                     /sec_met_domain="adh_short (E-value: 3.9e-31, bitscore:
                     107.1, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDNNIDVTDFRNRVVLITGGTSGMGLATARLLLEAGAEVVITGR
                     DDARLDRAAEQLAEVSDRGARLLTVRADSASLTDFDRLAALIRERHGRLDGVFANAGVG
                     VFQRSGEVTEQDFDRSVDVNFKGVFFTVQKVLPLLDAAGGGSIVINASWTLHRSLAVAP
                     VYAATKAAVHALARTGQ"
     CDS_motif       9611..9703
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B6R96_RS34165_0001"
                     /evalue="2.80E-08"
                     /label="PKSI-KR_m1"
                     /locus_tag="B6R96_RS34165"
                     /protein_end="45"
                     /protein_start="14"
                     /score="26.4"
                     /tool="antismash"
                     /translation="VVLITGGTSGMGLATARLLLEAGAEVVITGR"
     aSDomain        9611..9952
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B6R96_RS34165_PKS_KR.1"
                     /evalue="3.00E-15"
                     /label="B6R96_RS34165_PKS_KR.1"
                     /locus_tag="B6R96_RS34165"
                     /protein_end="128"
                     /protein_start="14"
                     /score="48.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VVLITGGTSGMGLATARLLLEAGAEVVITGRDDARLDRAAEQLAE
                     VSDRGARLLTVRADSASLTDFDRLAALIRERHGRLDGVFANAGVGVFQRSGEVTEQDFD
                     RSVDVNFKGV"
     misc_feature    complement(10153..10165)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.06"
                     /tool="antismash"
ORIGIN
        1 gttgcagtcc aggatgttct cggccgcctg gttggtgcag atgttgcgca tctgcgggta
       61 gtacggggtg tccgagtagc acatcacgtc gtactcgtcg gtgcagtgcg cgccacggct
      121 ggtgttcggg gcgctgttgt tgaccgcgcc caggttgtgg ccgagttcgt gcgcggcggt
      181 gtgaccgccc cagcagccgg agtccgtacg cccgtaggag gggccgaagt tgctctggtt
      241 ggcctggccg ggccgctcgt cgcccgcgaa cgtgccgatg ccgcagtaga cctgggtgtc
      301 ggcgaagatc atgtacttgc ggtcgcgacg gtcgaggccc ttgccggcga gcgcgttgtt
      361 ggtcgcgctg aactcggcca gcgccgaggc cgggagctcg atgttgagca ccgtcggggt
      421 gcagtcggcg gccgtcacat agcggatgtg acgtactccg ccggtctcct tggcactcgc
      481 cgagtagatg aggtccgcgt cggcggccca cttgcggaac gaggcgacgt actcggagta
      541 gcggtccttg ccgggcgcgt ggacgtagac gacctgtacg cggttgccgg tgctgccgtc
      601 gccgtcgcac tggacggtct ggcccgcggg gccggcggcg acgttctggc tgccggccgc
      661 ggccgccggt tcgggcgcgg aggccttggc ggccgaggcg tcggccgcgg gcgcgtcctg
      721 aggacgcccg ccgccttcct tgctggccgg gtcggcggcc gcggggctgg ccggatcggc
      781 cgccggagca gtctccttga cggccggctc gatgtccttc gtgatgtcga cgcccttggg
      841 cggggcgtcg gggccgtgcg tgcacagccc ggcggtggtg cggtagacac ccacgcactt
      901 gtcgcccttg ggcgcggcct ccagcccgtc gaagatcatg ccgcgcgcgg tctcgttgga
      961 gggcgcggcc gcgatcggct cgggctcctg gtcgcgcgcg ggcgcggcgg ccggtgcctc
     1021 ggcggcggcc tgtacgggcg ccgccgcctg ggcgccgtcg ccgattccgg aataggcgat
     1081 gcctgcggct atcagccccg ccgctgcggt ggcggcggtg acgagtatca accgccgggg
     1141 tttgcggcgg tggtcggcgg cggcaggccg tctgcgacgt cctgtcatgg gcacctcaaa
     1201 tcgttgtcgg aagactgggt gcgcggaagc ctgccagacg aatgcggagg agaattcgga
     1261 caaacggggg cgcgccccga gaaatcattc cgttacctat cggcctgatt tgacgaacaa
     1321 tcaactctca ataaatacag gccagttacg cgcgtcgctc cgcaatggtc cagtccttcg
     1381 agggtgggtt gttatcaaat cgagatatga agcggaggct tattgacggg aattcagtca
     1441 ggaattcacc taattgctac cagccgaatt ccttcggtca cgacccgtga ggtgcgaggg
     1501 ccacgtattg ctccgaccgg ccgtcgaagc ccgcgcgagg cgcaggagtt cacccgagga
     1561 acacggcaca gcgcccgatc gcgctgtccc gcccccgtcc tcacgtattc gtcgacaggg
     1621 cgccatgcgg cttggagttg tggcggggtg tgaggtggat caccctgaag gtggggatcg
     1681 gtcgtggatc agtcatcgag cacgctcagg tcgatgcgcg ccggtccggg cccggccgtc
     1741 gagcccgccc gggcagccgg cccgtacgcc ttcaccagcg aggagcggca catgaacccg
     1801 acatcaaggg cgaccggcac cgtccgcgcc gccgacgcgg catgagcccg acggcacatg
     1861 cgatctgacc tgccgccgga ccggggaagc gatcggccgt gaccggacgg gaacccgccg
     1921 aaacggaccg tacgagcgcg cgcgagccgg ggccgagact tactgtccgc accgagagcc
     1981 gctggccgct ggccgcagcg gtcgtcgcct cggcggtact caccctgctg ctccccgacg
     2041 acctgcgcct cggaccccgc tgggcgcttc ccgtcgccga gggcctcctg ctggtggccc
     2101 tgatctcggg agaccccggc cggatcagcc gccgctccac cgtcctgcgc tcagtggcga
     2161 tcgccctggt cgtcgtactc gtgggcagcg ccatctggtc gacggtccag ctgatcgacg
     2221 atctcatcca cggcgggagc gagaccaact cggccaatgc cctcctgctg gccggcggca
     2281 gcgtctgggc ctccaccgtc ctcgccttct ccctcctgta cttcgaactc gacagcggcg
     2341 ggccggccgc ccgggcccac cacatgcccc ccacgccggc gctcgacttt ccgcaacagc
     2401 tcagccccga actgaacgcc ccgcactggc gcccccacta catcgactac ctctacctcg
     2461 ggttcaccaa ttccaccgcg ctgagcccca ccgacgtcat gccactcgcc ccctgggcca
     2521 agagcgtcat gactctccag tccatccttt ccctcatgat cctgggactc gtcgttgccc
     2581 gggccgtgaa cgtcctggcc tgaaacggcc cggcggcggc cgcctcacgg tcaccgttgc
     2641 cgcagcaggg gccgtgggcc gtgggcggtg ggcggtgggg tgggccgggg cggccgcgtc
     2701 aggcgtagcg gtggcgcggt gcctgcgggt ccgtcccagc ggtcggcgtg ggcgaggccg
     2761 agcaggcgta cggcgtcccg gagttcggcg ggtgcgccgc aggcgcggag gcgtgcgggg
     2821 gcctcgcgca cgagccaggc ggccagtccg gtccgtacgc cctccacctc cgtctccgag
     2881 ctcctccggg ctgccccagt ggcactcgga ccggacctcg tcagctcggg cggtcatgcc
     2941 gcggaaggtg acggccagcc ggtccgcggg cgggccttca ccgccctgtc ggccgccgag
     3001 ggctgcggcg ccgcttctcg tacgcctccc ggatcccgcc ggccagcccc agaagcaccg
     3061 ccgtcccgac cgccaccgcg gctgcggtgc gcatgccccg gccgtgtacg tccccggcgg
     3121 cccgcgggga gaccttgccc tgcgggtcgt gcaccaccgc cagggactcg ccctccttcg
     3181 cgagccgcga gggggtgttg aggtactccg ggccgcccgc ggggcagtcc aggcggtggt
     3241 cgtacgaggt ccgggtcgtg gaggtccagt ggccctcggc gtccatggag gtttccgtct
     3301 cggtgcgctc ggtgaccttc agcacgacgc agctgatctc gacgccccgg tcctccagcg
     3361 tgctgtgccc cacggaggcg agtgccagga tggcgccgag ggcggcaggg agggcggaca
     3421 gcgcgatcag cgaggcctcg cgccgcgcgg cgacggcggc gtgccagccg agcaggacca
     3481 gcgggaggag caccccgccg aggaagaacc cccagttgcc cagcgacccg tacgccgact
     3541 gccgggccac cccgaacgcc agggccgcgg tcagcggcgg cgcggccaac gccaccgcgg
     3601 tccgccggat cccgcgtacc caccccccgt gccagcccgc catgcccgcc cccgtggctc
     3661 gtacctgtgc cctccaggta accgcgacgg cacgggcacg taaagagcac ggccgaggag
     3721 ggcggcacct ggtgacgctg aggctcccgg tcgggccccc gcaggccgcg gagacgctcg
     3781 ccgaactttc cgacccggcc ggggcgatgg gccggccgcg acgtcccgga catcgcggtg
     3841 cgctccccac ggggccggcc ccagtggaac gcagcggcga cctccggggc gaggacgtcc
     3901 gcgccgcgcc cagcggacag ctgtccgccg tggacatcgt ccggcccgga gtgaggggtc
     3961 agccgatgcg gacggtgatc tcggggaggg ggaggtcgga aaggttcagc tggagcccgg
     4021 tcacggtcag gtaggtctga gagtcggtca aggcggaggt ggtggacggc gcctgggtct
     4081 tcccgcgcgt gctcaccagc aggtaccagc ccccgcgctt gtagctgcgg gaggcttccg
     4141 ggcggtcgcc gttcgggttc agcgtccagc cctggcgctc caggtcggcg cagatcgcgt
     4201 tcatgtccga ctgcgcggcg gtctgctcgc ggacggccat ccagcccgtc ttgttcgagt
     4261 cggcaccggc cgcgccgatc gggcggccct gcgccgggtc gagccccgcc gcgctgaccg
     4321 cggtccggat cgcctcgtcc acggcgtccc gtgtgagggg cggtgacgtg gactccggtg
     4381 cgggcgccgc cgttgacggc gacggcgcgg gcgcgcccag gtggatgcgc ccgtcgtcgt
     4441 ttatctggat ctggtcaggc aggaccacgg cggccagact cacgatcaag gtcgcggcca
     4501 gcccgatcca caccctcttc aacagcgcgt tcaacgcgaa actccccccg agtgatcatt
     4561 cagagggagt ctcacacata ctgcccggcg gccgttgagc cgacccgtcc gggcacggtg
     4621 ggggaggggc cattccttga cggggtgtcg gcggcgcctt cgggcggtct cttcacggcg
     4681 ggctcttcgc ggcggtcgtt tgcggccggg atcgcgcgaa cgcgacaggt gcgcacaccg
     4741 gcgccatggg ccaggagaag cggtaggtat cagccatcga tcaacactga aggcgatgga
     4801 tgtctgaagt gtcggactgg gcaacttttt ccgactaatc atcttaggtc aggcgatagg
     4861 cgatctagaa atatccagac gatgccacat gattcgggca cggcggtttt cagtcaacgg
     4921 cgccatattc ctttgccggc aagtgcggac ccgtgaagga tctctctcgt tcccaacagg
     4981 gggaatcagg gagggaattc atgaagattg ccggtaggtc catcgctttc gccatcgcgg
     5041 gcgcagccat tgcggctgtc ggcctcgcga cgccggccac cgcggatgcg tctgcagccg
     5101 ccagcgcctc cggagccacc gtcaccgtcc accatcgcgg ggacggcact cagccgcctg
     5161 cagagctggg caacccctcc gaatggggtg tggtgacatt caagatggat gctgctgcag
     5221 cctctttcgg cgcgcagtcg caggcgtgca tcagcccgtc caccggtggc aactggtgtt
     5281 acggctggta cgcgcgagag gtcagccccg gggtgatcaa caagtattgc tactcgaatt
     5341 actatcagaa caccaagggg cactcgtcca cggtgaagct cgcgggcagt acgcgtcggg
     5401 tgtgggccgc ggccgggaac acctctaacg cgaacctcac tgcgggtctc gcctacacct
     5461 gctccaccta ctacagcgtc gactaggttc tggtcgcccg caccaatcag taactcctcc
     5521 tagggtgcgg taggttggtg agtcactccg gggctgctcg gtcgcccgtg cagcctcgga
     5581 gtggtgccac ctccaactcg gactcaccca ctgaacgggg gtagaacaat cacacgcttc
     5641 acacgtgccc acatggtgcc ggtcgctttg tctctcggag cgggtttgct gctcggcctg
     5701 gtgggccccg ttgccggaaa atgggacaat cccgtttgcg tcgccacggg cattgtcttt
     5761 tcgagtggtt ggccgtgggc ctgctacgca tttctggtgg gctattcccg ccgacccaaa
     5821 attgagtcgg cattgctggc gtctgtggga ttgaccatcg gcgtggtcac ctactacatt
     5881 ttcaaggata tgaatcccat cattccggca ggaatggaat ccgccccctc tgttccggct
     5941 ggaatggagt tggaatccgg cgcctccagc ggggggcaga ttctcgtatg gggaatagcc
     6001 gcttttgtgt tcggtgcgcc tgtgggactc atggggaacg tagcgcgcac gcccggaatc
     6061 ggtggccttc tgttccgtct gctcgtcccg ttcatcgcct tcttcgaggc gacccagcga
     6121 ttgaacgtag aggcggactc gcaggggccg gttttcgaca tgacctggaa cgcgactcgc
     6181 gtcgcagcat gcgtcgtcgc cgtggccctc gtggcacaca ccgtgtggaa ctggcgtgtt
     6241 cggcgtggcc gggccgacgg gcgagcggaa gctgtcgcgc ccgaacgtcg tctctgacct
     6301 ctgttccgcc ggggcggctg gaccgcaaca atgcaaagcg ccgtcccccg aagaggcccg
     6361 gtcgaccggc tgagcttcgg cttcgacacc gccgacaaag cacggcgccg cggaccggcc
     6421 cggctcaggc ggacgcttgc cctcgacctg ctcgagggcc ttggcgtcag cgcccatggc
     6481 atccctcgac accgcccggc ccgtctcagc gcccggccct tcctcgcgtc tttctcgtct
     6541 ggctcgtcgg cacccgtgcc tcgctgttcg gtgatgccgt cctgtacttc gcgctcggct
     6601 gggcggccag tgcccacggt ggtgggacgg gtgctctggt cctgaccgcc atcacgcttc
     6661 cacgcaccct gctgctgttg ctgggtggtg ccgtcggtga ccggttcggc gcgcgcctgg
     6721 tgatgatcac cggcgacgtc gtgatgctca cggtcactct cgtactggcc ctggtgggac
     6781 ccgactcggg agcatcgccc tggctcctcg tcctggtcgc cgtcgtcatt gcacaagagg
     6841 ccgccctggt gtgagccatg gggtcacgag cgatccggcg tacggcgtgg aagcacatcg
     6901 tgagggtgtt gccgccggac gcctggtcct gcacgacgtt ccttccggtg agtgtgggga
     6961 aggcgcctgc cggaaccatc tgatcgcccg gttccccaac gaaaccgcgt gagaaactcg
     7021 gtggtcggat cactgaggca gaagggtcgc ttgccatgtc ggacgccata ccgccgccgg
     7081 tgcatctcga cggggtggtg gacgggctgg cggagaaccc gtccctgccg tccgaactcg
     7141 tgcgccgcct cctcggtcat cgcacgggct tcggcgaggt ggccaagcgg ccggacctga
     7201 gcgatgacgt gatcgccgag atcattgcca tggacgatca ctggctcaca cactcgctcg
     7261 ccctcaaccg ccgcctccca caggccttcc ggatgatgct cgccgagcac ccggatcccg
     7321 caattcgcag ggctctggcc gttgctgcgg acggcgcacc gcgagggctg ttcgaacggc
     7381 tgctcggcga cgccgacccg caggttcgcg agcacttggc ggagagcgat cacgtgccgg
     7441 cagacctgcg ggcccggctc gcggcggacg agaacccgaa agtccgggcg acgcttgccc
     7501 agtggtggac gacggccccg gaaccggtgc gtcgaacgct gctgacagat cccgacgact
     7561 ccgtacgggc agcggcctgc gcgacctact tccgccggat tccccatccc gttccgccgg
     7621 tagacctcgt tccggagctg ctggccgacc cggtcacgcg cgccggggcg gtacgccact
     7681 gcacgctgga caccgccgcc gcccgccggc tggccgagga cccggacgat gacgtacgcg
     7741 cggaactcgc ggaacacccg gacctgtcac cggagttgcg cgacaagctc gccgaggatc
     7801 ccaaccagcg cgttgcgctc cgtatcttcg cccgtcagga caccccggag ccgactcgag
     7861 ccgcgatcca tgcacggatc ctgtccgaag tccccccact ggactggctc gaggaccacg
     7921 aagccctgga cgacgacgct ctcgaacggg aaatcctggg cgagctagcc cgcgcggagc
     7981 tccggacact gcgcctgcca tgggtgacga ccgaccccct gccgtacgtg gactcgccat
     8041 acgtctgctt ccgcgcctcg gcagcgatgt ccgagcagct cccgccgccg ctcgttgccc
     8101 gactgctcga cgacgaggag agcagcgtcc gtaccgcgat ggccctccac gcccgggacc
     8161 ggatcgatcc cgacaccgcc gagcgcatcg accggacctt ccgcccggac aaggtggtcc
     8221 gatggcgtcc ggccgacgac ttcccccttc cggcagacgt gcttcgacgc ctggccacgg
     8281 atgctgaccc gagaatgagg cagctggccc cgcgcgaccc cgacctgccc gtggaactcg
     8341 cgcgccgcct ggcagccgac cccgaccaca tggtgcgccg caccatcgcg gcccatccca
     8401 ggcttccggc cgaggagctg acgcggctgc tggccgatcc ggcggaatct gtggcggcca
     8461 ccgcagccgc aaaccccaac ctgccgacca caggcatgta ccagctgatc gccctcgcag
     8521 gcttgtgacg ctcgattgcg cgtcgccggt accggatcag gtcgggatgg ccggccgcgg
     8581 ccgccggctg agcggccgcg gaacggttgg ggccggcggc agccctgggg gagggggtca
     8641 ggggacgacg atggagaagg aggcgtcttc gtagacgccg ggctttccgg tgatgacgag
     8701 gaaggtgtcg gtgcgcgtcc cgcacgaggg gtgcggccac atcgagatcc ggatgtcgta
     8761 ttcgaagctg atgtactgca gggtggcgtt ggggacgagc ttgcggatgt cgaggtcctt
     8821 gtcctccagc tcgacgcagt agtggcccgc cgctggcttg gtgacggctt cgatgccctt
     8881 ggaccggttg acgctgccgt tggcgttgac cacggccgcg gcctgcgcgt agggggcggt
     8941 caccttcgcg gagccggggg gtgcggccac cgctgttccc gcccatgttc cgccggcgat
     9001 gagcccgagg gcgacgctgg tccacacggc tgcgcgggtc ttcttgctca tgggcatgtg
     9061 cagttttccc ctctgtggtg gtgccggtgg cctccccggg ccgtcggcac acccgaagct
     9121 aggggtgccg ccccggcctt cgtggtcctc acgcggtgaa accaccggtt gagggggcgc
     9181 gggaggtgct cgacccggac cgcggcgcgc cttcggcgcg tgtggcgtgg gcttccccgg
     9241 gcggggtctg ttccgggctt ggggacggac cgcgggtgtg cagtggcgtt tcgccggtga
     9301 atcgggcgct ccgggagggt gaacctgcct ctgcagatcc cgtcgatgaa ggacacgccc
     9361 agtccgggtt cccaagggcg gaccgagtgg agattggaca gcgagatcac cccatcgggc
     9421 ttccactgcc cctcgcgcag ccacacgtcc agttcccacg ggccgggcag caggtcctcc
     9481 ttgccggacg gccgaggctg cgtgccccca ggagacccag gttgatctgg gcctggttgg
     9541 cctgggggct ggtggcgagg ctgtggtcat gaccgacaac aacattgatg tgaccgactt
     9601 ccgtaaccgt gtcgtcctga tcaccggcgg aaccagtggg atgggcctgg ccaccgcgcg
     9661 tctgctcctg gaggccggcg ccgaggtcgt catcaccggc cgtgacgacg cccgcctcga
     9721 ccgcgcggcc gaacaactgg ccgaggtgtc cgaccggggt gcccggctgc tcaccgtccg
     9781 ggccgactcc gccagcctca ccgatttcga ccgcttggcc gccctgatcc gtgaacgcca
     9841 cggacggctg gacggggtgt tcgccaatgc cggggtcgga gtgttccagc gcagtggcga
     9901 ggtcacggag caggacttcg atcgcagcgt cgacgtcaac ttcaaggggg tgttcttcac
     9961 ggtccagaag gttctgccgc tccttgacgc ggcgggcggc ggttccatcg tgatcaacgc
    10021 ctcgtggact ctgcaccgaa gcctggccgt cgcacccgtg tacgcggcca ccaaggccgc
    10081 cgtccacgct ctggcccgca cggggcagtg atctcgccga gcgcggcatc cgggtcaact
    10141 cggtcagccc gggttacatc gtcaccgaga tgttcgatgc cgccaacccg gatcccgccg
    10201 cgcactcctg caccctgaag acgtcgccct gccggacttc ggaggccggc gccgggtcgc
    10261 gggcctgcgc cgcgaggaga tcgcgcagct cgccggagtg agcgtcgact acaacacgcg
    10321 gatggaacag ggccgcgtgc ccaacccctc gggcgcggta ctcgacgccc tcgcccgcgc
    10381 actgcggctg gacggggatg cgacacggca cctgcaccgc ctcgcccgac cgcagtcctc
    10441 cgcccggaac gttccccggc gccaggccca gccgcaacgc gtgcgc
//
