LOCUS       NZ_CP020555            11350 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces sp. Sge12 chromosome, complete genome.
ACCESSION   NZ_CP020555
VERSION     NZ_CP020555.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. Sge12
  ORGANISM  Streptomyces sp. Sge12
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7983613)
  AUTHORS   Tao,M., Xu,J., Xu,M., Liu,K., Zhao,Z. and Peng,Q.
  TITLE     Genome sequence of Streptomyces sp. Sge12, producing unknown
            compounds against rice blast disease
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7983613)
  AUTHORS   Tao,M., Xu,J., Xu,M., Liu,K., Zhao,Z. and Peng,Q.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2017) School of Life Sciences and Biotechnology,
            Shanghai Jiao Tong University, Huashan Road 1954, Shanghai 200030,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: RS_HGAP Assembly v. 3; BWA v. 0.7.10; Bowtie v. 2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 85.0x
            Sequencing Technology :: Illumina HiSeq 4000; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 03:12:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,312
            CDSs (total)                      :: 7,216
            Genes (coding)                    :: 7,106
            CDSs (with protein)               :: 7,106
            Genes (RNA)                       :: 96
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 111
            CDSs (without protein)            :: 110
            Pseudo Genes (ambiguous residues) :: 0 of 111
            Pseudo Genes (frameshifted)       :: 32 of 111
            Pseudo Genes (incomplete)         :: 91 of 111
            Pseudo Genes (internal stop)      :: 8 of 111
            Pseudo Genes (multiple problems)  :: 18 of 111
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:35:20
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1924917
            Orig. end                         :: 1936267
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP020555.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11350
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="22"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11350
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11350
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6350](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6350
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            913..1902
                     /locus_tag="B6R96_RS08545"
                     /old_locus_tag="B6R96_08550"
     CDS             913..1902
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016641835.1"
                     /locus_tag="B6R96_RS08545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B6R96_08550"
                     /product="hypothetical protein"
                     /protein_id="WP_203351606.1"
                     /transl_table=11
                     /translation="MNALSRRLRLALTLTAALLLAGGSLGYVLHARHREQPPGQRADAS
                     FRIEEPGLYFRDAAGGRVARQPDAGPPRVTGGPSCDRFHTAGDHALCLRKLPGVPARTE
                     ALVLDRGLREVRRVTVPGIPNRARVSASGRILSWTTFTTGDSYNTAAFSTRTAILDLRT
                     GYLIKSIEQIPLTLAGARHHDSDVNYWGVSFAADDNRFYATVSTRGATHLVEGDLRAWS
                     AKALRENAECPSLSPDGARVAFKKKVSDDPRAPWRLYVLDLATMREQPLAEPHGVDDQA
                     AWLDDSTLAYALPGQDGRASDIWSVPADGTGPPRLLVPGASSPAHVGQ"
     gene            complement(1903..2547)
                     /locus_tag="B6R96_RS08550"
                     /old_locus_tag="B6R96_08555"
     CDS             complement(1903..2547)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004956394.1"
                     /locus_tag="B6R96_RS08550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B6R96_08555"
                     /product="ABC transporter"
                     /protein_id="WP_081522152.1"
                     /transl_table=11
                     /translation="MTALLRYQGALLLRSQRWLAPLITYAAFVAAGIRPGDPALDSLGF
                     AAAGLVPVTAWLVRICVTGEPDAARDCTAAAAGPVRVHTAALLTALAGALLAGAAAAAA
                     ALLIGDRAGAGTGGAALAGALAVAACALTGAAVGALCSRPLVRRRGYGVLAGTLGSLAA
                     WLLAPSPAHGAVSALVSAAHSGTAPLPLLPLAGALLLAAGAGTAAALAAAR"
     gene            complement(2544..3359)
                     /locus_tag="B6R96_RS08555"
                     /old_locus_tag="B6R96_08560"
     CDS             complement(2544..3359)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267204.1"
                     /locus_tag="B6R96_RS08555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B6R96_08560"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_053703493.1"
                     /transl_table=11
                     /translation="MNLTGVGRRYGRRRPWVLRGITLELPRGALVRIEGGNGGGKSTLL
                     RLLAGIDAPTEGRITGRPPRTGYVPERFPAALPLTAASYLTHLGRVHGLPRAEAARRAA
                     DRLERFGAAAYARTPMAELSKGSSQKVAVAQALLAEPGLLVLDEAWTGLDAPARAELDR
                     AVAERTAAGGTVVFVDHDPRRLAGVADAHHRVEGGTLVPGTGAQGPRVRIHAVGAPGSP
                     LPPYAGPGAVPAPGGGVLLTVDGERSDAVLRELLTARPPWHIRTVEELP"
     gene            complement(3356..4030)
                     /locus_tag="B6R96_RS08560"
                     /old_locus_tag="B6R96_08565"
     CDS             complement(3356..4030)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153329.1"
                     /locus_tag="B6R96_RS08560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B6R96_08565"
                     /product="AIM24 family protein"
                     /protein_id="WP_081522153.1"
                     /transl_table=11
                     /translation="MKSDLFASENLARTAVAPGMSLQNAKSVKYNVYGEMLARQGSMVA
                     FRGNLQFERKGQGIGGMLKRAVTGEGLALMSVRGQGEAWFAHQAGNCFIIDFEPGDALT
                     INGRNVLCFDPTLSYEIKMVKGAGMTGGGLFNSLFTGTGKLAVVCDGHPIIIPVTPQAP
                     VHVDTDAVVGWSAQLETGLHRSQSVGSMIRGGSGEAVQLKLSGEGFVIVRPSEVTETAA
                     GH"
     gene            4102..4854
                     /locus_tag="B6R96_RS08565"
                     /old_locus_tag="B6R96_08570"
     CDS             4102..4854
                     /EC_number="3.1.1.29"
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267202.1"
                     /locus_tag="B6R96_RS08565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B6R96_08570"
                     /product="aminoacyl-tRNA hydrolase"
                     /protein_id="WP_079406441.1"
                     /transl_table=11
                     /translation="MSSQHTNDISDVPAVGEDSPFRQEHVRRDEAPQFVLPLVVRIEKA
                     EPPARTDALETAARAVLVLLTDERAQGDGEWAGAVRDWQDARIRKVVRRARGAEWRKAE
                     TLPGVTVDGDGAQVRVFPPVPLDGWPKELAKLQVSGTDLDDPEPVAAVTEPGLPVLWLN
                     PGLDMSAGKAMAQAGHAAQLAWWELTGAERAAWQESGFRLAVRTAPRERWAELGGSGLP
                     VVRDAGFTEIAPGSATVVADHPALRARL"
     misc_feature    complement(4996..5010)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 15.61"
                     /tool="antismash"
     gene            5001..6350
                     /locus_tag="B6R96_RS08570"
                     /old_locus_tag="B6R96_08575"
     CDS             5001..6350
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018888544.1"
                     /locus_tag="B6R96_RS08570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B6R96_08575"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_081522154.1"
                     /sec_met_domain="DUF692 (E-value: 3.5e-89, bitscore: 297.3,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPMAHLGVGIGWRPEIADAVERLPGLDWVEVVAENVCPGHLPES
                     LLRLRERGTRVVPHGVSLGLGGADRPEPAKLAALGERAVALGAPLVTEHIAFVRTSSPV
                     LEAGHLLPVPRTRDALDVLCENVRIAQDSLPVPLALENIAALFSWPGEELTEAQFLTEL
                     VERTGVRLLIDVANLHTNRVNRGEDPAAVLDAIPLEALAYVHVAGGIERDGVWHDTHAH
                     PVPPVVLDLLAALRSRVDPPGVLLERDDDFPAEAELAGELAAIRAVVTAGPPAPGRPAV
                     AGSGPAAAEPRPDAEPDPAAERDAADEPLPVEESARTRVALGQAALLSALVAGTPVPEG
                     FDRRRIRVQARALAAKRADVVARLAPELPEILGGPDPYREAFLSYAKGRPMTAGYRRDA
                     LDFAEDLLIRDLPADPVARRRLTAWWRDRTGARPPRRIVRWARALAGRAA"
     gene            6347..7393
                     /locus_tag="B6R96_RS08575"
                     /old_locus_tag="B6R96_08580"
     CDS             6347..7393
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049031.1"
                     /locus_tag="B6R96_RS08575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B6R96_08580"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_107475685.1"
                     /transl_table=11
                     /translation="MNLLAVAIWIAVLVSSALLITGLRRARSAPAGPAPALHDLSEAAF
                     VVGGPGTVVDVALVSMLGDGRLVAGGPGIVQVRPGARAADPAERAVLQAHRGAPSGWLY
                     QVRYTAMCDPAVQEIGDALAARGLITPPGSGLRRFRRWGLIQALVCALLFPVSMVLTFV
                     ALAVDSGSAVPFIVKVIFALVGGIVVGLVCAAGAKSRVTGAGARALRAVRSAHLNDRAP
                     HVQTALFGLRGLRDPYLRQQLVPAARGTRLAAAQSRTGSHGTGGSAHWSGAEVLPIVWC
                     AGSDGGSGGGSSCGSGSGCGGSTGCGSSGGGCGSSGGGSSCSSSSSSCGSSSSCGSSSS
                     SSCGSSSS"
     gene            7566..9233
                     /locus_tag="B6R96_RS08580"
                     /old_locus_tag="B6R96_08585"
     CDS             7566..9233
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (118-328). E-value:
                     2.3e-18. Score: 58.6. Matches aSDomain:
                     nrpspksdomains_B6R96_RS08580_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006380016.1"
                     /locus_tag="B6R96_RS08580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B6R96_08585"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_081522156.1"
                     /sec_met_domain="PF00561 (E-value: 4.3e-23, bitscore: 80.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTGLAGRTAPVAALALLLCAPAHLPAHALEGTPPGSPGGTAAEA
                     AEAAGAALVARRAAARGGGLDFGRCPDVEGLSGPVRCATLRVPLDYARPDGPQISLTVS
                     RTTATGARGAARQGALIHNPGGPGASGMHFPLVADLPGWESIAAAYDLVGYAPRGVGRS
                     APLSCQDPATRAAGPTQVPAEPSPAYKRQRLAAARAYARGCSRRAGAALPYYTTLDNAR
                     DLDVLRAALGERKLSFMGASYGTYLGAVYATLYPGRVRRMVLDSAVDPDPRRIWYRNNL
                     DQSAGFERRWYDFRAWAARHHDTYGLGATPAAVQASYERVRDAVARTPAGGVVGTGELR
                     AAYLQAAYYDDVWPERAAALAAHLRGDPAPLTAQAGPAADPAAAAEAENATAVYTAVLC
                     NDAPWPADWETWDRDHTELARRAPFETWANAFLNLPCASWPVRERQRPVAVGDGPQRLP
                     ATLVVAAERDGATPYPGALELQRRLGAGASLVTEAGAGSHGVVGGRNDCVDRHVERYLL
                     TGATPGWRVTCAPHPEPAPVSLDDRAAGARRALLPPVV"
     aSDomain        7920..8549
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B6R96_RS08580_Abhydrolase_1.1"
                     /evalue="2.30E-18"
                     /label="B6R96_RS08580_Abhydrolase_1.1"
                     /locus_tag="B6R96_RS08580"
                     /protein_end="328"
                     /protein_start="118"
                     /score="58.6"
                     /tool="antismash"
                     /translation="ALIHNPGGPGASGMHFPLVADLPGWESIAAAYDLVGYAPRGVGRS
                     APLSCQDPATRAAGPTQVPAEPSPAYKRQRLAAARAYARGCSRRAGAALPYYTTLDNAR
                     DLDVLRAALGERKLSFMGASYGTYLGAVYATLYPGRVRRMVLDSAVDPDPRRIWYRNNL
                     DQSAGFERRWYDFRAWAARHHDTYGLGATPAAVQASYERVRDAVART"
     gene            complement(9364..10077)
                     /gene="hemQ"
                     /locus_tag="B6R96_RS08585"
                     /old_locus_tag="B6R96_08590"
     CDS             complement(9364..10077)
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018888541.1"
                     /locus_tag="B6R96_RS08585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B6R96_08590"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_030386076.1"
                     /transl_table=11
                     /translation="MTAPEKIPNAGKKAKDLNEVIRYTLWSVFKLKDVLPEDRTGYADE
                     VQELFDQLGAKDITVRGTYDVSGLRADADVMIWWHAETADELQTAYNLFRRTRLGRALE
                     PVWSNMALHRPAEFNKSHIPAFLADEVARDYVSVYPFVRSYDWYLLPDEDRRRMLADHG
                     KMARGYPDVRANTVASFSLGDYEWMLAFEADELYRIVDLMRHLRASEARMHVREEVPFY
                     TGRRKSVADLVAGLA"
     misc_feature    10608..10622
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     misc_feature    complement(11043..11058)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.12"
                     /tool="antismash"
     misc_feature    complement(11043..11058)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.33"
                     /tool="antismash"
ORIGIN
        1 cgcggcgctc gccgccgacc ggctcggcaa gggcatccgt accgcaccgc gcgacgccct
       61 gatctcgctc agcgggccca cggagaccct cggccggtcc ttcggcgtgc accgcgccat
      121 ggacaccacg ggggccctgc tcgggccgct cgccgcgttc gccgtgctgt gggccaccgc
      181 cgacgcctat gacgcggtgt tcgccgtcag tttctgcacc ggcctgctcg gcgtgctcct
      241 gctcgtggtg tacgtcccgg ccgcgcccgg tccggccacc gcacccccca cgcccatcgc
      301 gccccgggcc gccccaccgc ggccctcggc cctgcgcgat ccggccttcc gccgcgtgct
      361 gtacgcctcg gccgtgctcg gcgccaccac catcggcgac tccttcctct acctgctgct
      421 cctgcgcgga ctcgacctgc cgcccgccct gttcacgctg cttccgctgg ggcccgccgc
      481 cgtctacctc ctgctcgccg tccccgcggg caggatcgcc gaccgcaccg gccgccggac
      541 ggccttcctg accgggcacg ccgccctgct cggcgcgtac ctgctgctgc tcgcccccgt
      601 ctccccaccg accgtcgtgg gggtgctcgc cctgctgggc gtcttctacg ccgccaccga
      661 cggggtcctg atggcgctcg ccgcgccagc gctgcccgcg gccggccggg cgggcgggtt
      721 cgccgtgctg cagaccggcc aggcgttggc ccggctgctg ggcgccgccg gattcggggc
      781 ggcctggacc ctctggggcg cgcggcccgc cctctgggcc gcggccctcg cgctggccgg
      841 ggcgctcgcg gccgcctcgc gcctcatgcc cgccgacgcg cccgccccat ccccgaccgc
      901 accggaggcc ccgtgaacgc gctgtcccgt cggctccgcc tcgccctcac cctcaccgcg
      961 gccctgctgc tggcgggcgg ctcgctgggc tacgtactcc acgcccggca ccgcgaacag
     1021 ccgcccgggc agcgggccga cgcctccttc cgcatcgagg aaccgggcct ctacttccgg
     1081 gacgcggccg gcgggcgggt cgcgcgccaa cccgacgcgg gcccgccccg cgtgaccggc
     1141 ggcccgtcct gcgaccgctt ccacaccgcc ggggaccacg ccctgtgcct gcgcaagctg
     1201 cccggggtcc cggcccgtac cgaggcgctc gtactcgacc gggggctgcg ggaggtccgc
     1261 agggtgaccg ttcccgggat cccgaaccgg gcccgcgtct cggcctcggg ccggatcctg
     1321 tcctggacca ccttcacgac cggcgactcc tacaacaccg ccgcgttctc cacccggacg
     1381 gcgatcctgg acctgcgcac cggctacctg atcaagtcga tcgagcagat cccgctgacc
     1441 ctcgccgggg cccgccacca cgactccgac gtcaactact ggggcgtgag cttcgccgcc
     1501 gacgacaacc gcttctacgc caccgtctcc actcggggcg ccacccacct cgtcgagggc
     1561 gacctgcgcg cctggtcggc gaaggcgctg cgggagaacg ccgaatgccc ctcgctgtcc
     1621 ccggacggcg cccgcgtcgc cttcaagaag aaggtctccg acgacccccg ggcaccctgg
     1681 cggctgtacg tcctggacct ggcgacgatg cgcgagcagc cgctggccga accccacggc
     1741 gtcgacgacc aggccgcctg gctcgacgac tcgaccctcg cctacgccct gcccggacag
     1801 gacggccgcg cgagcgacat ctggtcggtc ccggcggacg gcacgggccc accccgtctc
     1861 ctcgtcccgg gcgcctcctc ccccgcccac gtcggccagt agctagcgcg cggcggccag
     1921 ggcggccgcc gtccccgccc cggcggccag cagcagcgca ccggccaggg gcaggagcgg
     1981 cagcggcgcc gtccccgagt gcgcggccga gaccagcgcg gacaccgcgc cgtgggccgg
     2041 ggaaggtgcg agcagccagg ccgccaggga gccgagggtc ccggccagga cgccgtagcc
     2101 ccggcgccgg accagcggcc ggctgcacag ggcacccacg gccgcgccgg tcagggcgca
     2161 ggccgccacc gcgagggctc cggcgagggc ggccccgccc gtgccggccc cggcccggtc
     2221 gccgatgagc agggccgcgg cggccgccgc ggctccggcg agcagtgccc cggccagggc
     2281 ggtgaggagg gccgccgtgt ggacccgtac gggaccggcc gccgcggccg tgcagtcgcg
     2341 ggccgcgtcg ggttcgccgg tcacgcagat ccggaccagc caggcggtca ccgggaccag
     2401 gccggcggcc gcgaacccga gggagtccag cgccgggtcg cccgggcgga tcccggcggc
     2461 cacgaaggcg gcgtacgtga tcaggggcgc gagccatcgc tgggagcgca ggagcagggc
     2521 gccctggtaa cggagcaggg cggtcacggg agttcctcca cggtgcggat gtgccagggc
     2581 ggccgggccg tgagcagttc gcgcaggacc gcgtcggagc gttcgccgtc gacggtgagc
     2641 agtactcccc cgcccggggc gggcactgcg cccgggcccg catacggggg cagcgggctg
     2701 ccgggcgctc cgacggcgtg gatccgcacg cggggtccct gcgccccggt cccggggacg
     2761 agggtcccgc cctcgacccg gtggtgggcg tcggccacgc ccgcgagccg tcgcggatcg
     2821 tggtcgacga acacgacggt gcctccggcc gcggtgcgct cggcgacggc gcggtccagc
     2881 tcggcccggg cgggagcgtc caggccggtc cacgcctcgt cgaggacgag cagccccggt
     2941 tcggcgagca gggcctgggc gacggccacc ttctggctgc tccccttgga cagttcggcc
     3001 atcggggtgc gggcgtacgc ggcggcgccg aaccgctcca gccggtcggc cgcccggcgg
     3061 gccgcctcgg cgcgcggcag tccgtgcacc cggcccaggt gggtcaggta ggaggcggcc
     3121 gtgagcggga gcgccgccgg gaagcgttcg ggtacgtagc cggtgcgggg cgggcggccc
     3181 gtgatgcgtc cctcggtcgg ggcgtcgatc ccggcgagga gccgcagcag ggtggacttg
     3241 ccgccgccgt tgccgccctc gatccgtacg agggcgcccc gcgggagctc cagcgtgatg
     3301 ccgcgcagca cccagggccg gcgccgtccg tagcggcggc ccacaccggt caggttcagt
     3361 gcccggccgc cgtctcggtg acctcgctcg ggcggacgat gacgaagccc tcgccgctca
     3421 gcttcagctg gaccgcctcg ccggagccgc cgcggatcat cgagccgacc gactgggagc
     3481 ggtgcaggcc ggtctccagc tgggcgctcc agccgaccac cgcgtccgtg tccacgtgga
     3541 ccggcgcctg aggggtgacc gggatgatga tcgggtggcc gtcgcagacg acggcgagct
     3601 tgccggtgcc ggtgaagagg ctgttgaaga gaccgcctcc ggtcatgccg gcgcccttca
     3661 ccatcttgat ctcgtaggac agcgtggggt cgaagcagag cacgttgcgg ccgttgatgg
     3721 tgagggcgtc acccggctcg aagtcgatga tgaagcagtt gccggcctgg tgcgcgaacc
     3781 aggcctcgcc ctgcccgcgt acggacatga gcgcgaggcc ctcgcccgtc acggcgcgct
     3841 tgagcattcc gcctatgccc tgtcccttgc gctcgaactg gaggttgccg cggaaggcga
     3901 ccatcgagcc ctggcgggcc agcatttcac cgtagacgtt gtacttcacc gacttggcgt
     3961 tctgcaggct catgccgggg gcgacggccg tccgggccag gttctcggac gcgaaaaggt
     4021 cactcttcat ggctgcgatc ctcacccggg ccgcccaccc ggggcatcat cctgaaggtg
     4081 gaggctggca tccttggcgg gatgagcagc cagcacacca acgacatctc cgacgtcccc
     4141 gcggtcgggg aggacagccc cttccggcag gaacacgtac ggcgcgacga ggccccgcag
     4201 ttcgtgctgc cgctggtggt gcggatcgag aaggccgagc cgcccgcccg taccgacgcc
     4261 ctggagacgg cggcccgcgc ggtgctggtc ctgctcaccg acgagcgggc gcagggcgac
     4321 ggcgagtggg ccggggcggt ccgcgactgg caggacgcac ggatccgcaa ggtggtccgg
     4381 cgcgcccgcg gggcggagtg gcgcaaggcg gagaccctgc cgggcgtcac ggtcgacggg
     4441 gacggcgcgc aggtacgggt cttcccgccg gtgcccctcg acggctggcc caaggaactg
     4501 gccaagctcc aggtgtcggg caccgatctg gacgacccgg agcccgtcgc cgccgtcacg
     4561 gaaccgggcc tgccggtgct gtggctcaac ccgggcctcg acatgtcggc cggcaaggcc
     4621 atggcccagg ccgggcacgc ggcccagctg gcgtggtggg agctgacggg ggcggagcgg
     4681 gccgcctggc aggagtccgg tttccggctg gcggtacgga cggccccgcg cgagcggtgg
     4741 gcggagctgg gcgggagcgg actgccggtg gtccgggacg ccgggttcac cgagatcgcg
     4801 ccgggcagcg cgacggtggt cgccgaccat ccggcactgc gggcccggct gtgacggacc
     4861 ggctctgacg ggccggctcc gacggggccc cggtcggcgg gaacctcaaa tgttcctctg
     4921 aacgtccccc tctgcggttg gcgcgactcc gtcggggcca tgacaccggc acacggtgcg
     4981 acgagagggg gcgaggggac atgaaaccca tggcacacct gggggtgggc atcggctggc
     5041 ggccggagat cgcggacgcc gtcgaacggc ttcccggcct ggactgggtc gaggtggtgg
     5101 ccgagaacgt atgcccgggc cacctgcccg agtccctgct gcggctgcgc gagcggggca
     5161 cgcgcgtggt gccgcacggg gtctcgctcg gcctcggcgg ggcggaccgc cccgagccgg
     5221 cgaagctcgc ggcgctcggc gaacgggcgg tggcgctggg ggcgccgctc gtcaccgagc
     5281 acatcgcctt cgtacggacc tcctcgccgg tgctggaggc cgggcacctg ctgccggtgc
     5341 cgcgcacccg cgacgcgctg gacgtgctgt gcgagaacgt gcggatcgcg caggactccc
     5401 tgcccgtgcc gctggccctg gagaacatcg ccgcgctgtt ctcctggccg ggcgaggagc
     5461 tgacggaagc gcagttcctc acggaactgg tcgagcggac cggtgtccgg ctgctgatcg
     5521 acgtggccaa cctgcacacc aaccgggtca accggggcga ggacccggcc gccgtgctgg
     5581 acgcgatccc gctggaggcg ctcgcgtacg tgcacgtggc gggcgggatc gaacgggacg
     5641 gcgtctggca cgacacccac gcgcacccgg tcccgccggt cgtcctcgac ctgctggccg
     5701 cgctgcgctc ccgggtggac ccgccgggcg tcctgctgga gcgcgacgac gacttccccg
     5761 cggaggcgga gctcgcgggc gaactggccg cgatccgcgc ggtggtgacg gcggggccgc
     5821 ccgcccccgg ccggccggcc gtcgccgggt ccggcccggc ggccgccgag ccgcgcccgg
     5881 acgcggagcc ggatcccgcc gcagagcggg atgccgccga cgagccgctt ccggtcgagg
     5941 agtcggcccg gacccgggtg gcgctcgggc aggccgcgct gctgtcggcg ctggtggccg
     6001 ggacccccgt gcccgagggc ttcgaccgcc ggcggatccg ggtgcaggcc cgggcgctgg
     6061 ccgccaagcg ggccgacgtg gtggcccggc tggctcccga gctgccggag atcctgggcg
     6121 gcccggaccc gtaccgcgag gccttcctct cctacgccaa gggccgcccg atgacggccg
     6181 ggtaccgccg ggacgcgctg gacttcgccg aggacctgct gatccgggac ctgccggccg
     6241 accccgtcgc ccggcgccgg ctcaccgcct ggtggcggga ccgcaccggg gccaggccgc
     6301 cgcgccggat cgtgcgctgg gcccgggcgc tcgcggggag agcggcatga acctcctcgc
     6361 cgtggcgatc tggatcgccg tcctcgtctc ctccgccctg ctgatcaccg ggctccgccg
     6421 agcgcgctcc gcgcccgccg gacccgcccc cgccctgcac gacctgtccg aggccgcctt
     6481 cgtggtgggc ggccccggca ccgtcgtgga cgtcgcgctc gtctccatgc tcggggacgg
     6541 ccggctggtg gccggcggtc cgggcatcgt ccaggtacgc cccggggcgc gggccgccga
     6601 ccccgccgag cgggccgtcc tccaggccca ccggggggcg ccctcgggat ggctctacca
     6661 ggtgcgctac accgccatgt gcgacccggc cgtccaggag atcggggacg cgctggccgc
     6721 ccgcgggctg atcaccccgc ccgggtccgg actgcggcgc ttccgccgct ggggtctgat
     6781 ccaggccctg gtgtgcgcac tgctgttccc ggtgtcgatg gtgctgacct tcgtcgcgct
     6841 cgccgtcgac tccggctcgg cggtgccgtt catcgtgaag gtgatcttcg ccctggtggg
     6901 cggcatcgtc gtgggcctgg tctgtgcggc cggggccaag agccgcgtca ccggggccgg
     6961 ggcgcgtgcg ctgcgcgcgg tccgctccgc ccacctgaac gaccgggccc cgcacgtgca
     7021 gaccgcgctg ttcgggctgc gcggtctgcg ggacccgtac ctgcgccagc agttggtgcc
     7081 cgccgcccgc gggacccggc tggccgcggc gcagtcgcgc acgggctccc acggcacggg
     7141 cggctccgcg cactggtccg gggccgaggt gctgccgatc gtctggtgcg ccgggagcga
     7201 cggcggcagc ggtggcgggt cgagctgcgg cagtggctcg ggctgcggcg gcagtacggg
     7261 ctgcggctcc tcgggcggcg gctgcggctc gtccggcggc ggctccagct gttcgagcag
     7321 cagctcgagc tgcggcagtt cgtcgagctg cggcagctcc tcgagctcca gctgcggcag
     7381 cagcagctcc tgacggccgg aggcacggcc accgggcgcg gctggcggac acgattggct
     7441 ggtacggcaa ccgggggcgg aatccgcggc aacgggagca tcggcgccga cacccgccgg
     7501 tgatccttta caacggcagc gcccgggcct ctcatcggtt catcggatga gaggaaggag
     7561 ccgccatgcg gacgggactc gcaggtcgca cggcccccgt ggcggcgctc gccctcctcc
     7621 tgtgcgcccc ggcccacctg cccgcccacg ccctggaggg caccccgccc ggctcccccg
     7681 gcgggacggc ggccgaggcg gccgaggcgg ccggcgccgc cctcgtcgcc cgccgcgccg
     7741 cggcccgggg cggcggcctc gacttcggcc gctgccccga cgtcgagggc ctctccggcc
     7801 cggtccggtg cgccaccctg cgcgtaccgc tcgactacgc ccgcccggac ggcccgcaga
     7861 tctccctcac cgtcagccgg accaccgcca ccggtgcccg gggcgccgcc cgccagggcg
     7921 cgctgatcca caatccgggc ggcccggggg cctccggcat gcacttcccg ctcgtcgccg
     7981 acctgccggg ctgggagtcc atcgccgccg cctacgacct cgtcggctac gccccgcgcg
     8041 gcgtcggccg ctccgccccg ctgtcctgcc aggaccccgc cacccgggcc gcgggcccca
     8101 cccaggtacc ggccgagccc tcccccgcgt acaagaggca gcgcctcgcg gccgcccggg
     8161 cgtacgcccg cggctgctcg cggcgggccg gcgcggccct gccgtactac acgacgctcg
     8221 acaacgcccg cgatctggac gtgctgcggg ccgcactcgg cgagcggaag ctgagcttca
     8281 tgggcgcctc gtacggcacc tacctcgggg ccgtctacgc caccctgtac ccgggccggg
     8341 tccgccggat ggtcctcgac tcggcggtcg atcccgaccc gcgccgcatc tggtaccgca
     8401 acaacctcga ccagtcggcc ggcttcgagc gccgctggta cgacttccgc gcctgggcgg
     8461 cccgccacca cgacacgtac ggcctcggcg ccacgcccgc ggccgtgcag gcgagctacg
     8521 aacgggtccg ggacgcggtg gcccgtacgc cggcgggcgg ggtcgtgggg accggcgagc
     8581 tccgggccgc ctacctccag gccgcgtact acgacgacgt gtggcccgaa cgggcggcgg
     8641 ccctcgcggc ccacctgcgc ggcgatccgg ccccgctgac cgcccaggcc ggccccgcag
     8701 ccgaccccgc ggcggcggcc gaggccgaga acgcgacggc ggtgtacacg gcggtgctgt
     8761 gcaacgacgc cccgtggccc gcggactggg agacctggga ccgtgaccac accgaactgg
     8821 cccgcagggc ccccttcgag acctgggcca acgccttcct gaacctgccg tgcgcctcct
     8881 ggccggtgcg cgagcggcag cggccggtgg cggtcgggga cgggccgcag cggctgccgg
     8941 cgaccctggt ggtggcggcg gagcgggacg gggcgacccc gtacccgggc gcgctcgaac
     9001 tccagcggcg gctcggcgcc ggggcttcgc tggtgacgga ggcgggagcc ggctcccacg
     9061 gagtggtcgg cggacgcaat gactgcgtgg accgtcacgt ggagcggtat ctgctgacgg
     9121 gcgccacccc ggggtggcgc gtcacgtgcg cgccgcatcc ggagcccgca ccggtgtcgc
     9181 tggacgaccg ggcagcgggc gcccgcaggg cgctgctgcc gccagtcgtc tgaacttccg
     9241 ggcgggatct ccggctgcgt cgtttcgggg gcaggggccg tctttcggac cagcctcccg
     9301 atccaccgga ggaactcacc tgacggtgtg gtcgtcctcc ggtccttccc cccaggggag
     9361 gtctcaggcg agtccggcca ccaggtcggc gacggacttg cggcgcccgg tgtagaaggg
     9421 cacttcttca cggacgtgca tacgggcctc ggaggcacgc aggtgacgca tcaggtcgac
     9481 gatgcggtac agctcgtccg cctcgaaggc cagcatccac tcgtagtcgc ccagggagaa
     9541 ggaggcgacg gtgttggcgc gcacgtcggg gtagccgcgc gccatcttgc cgtggtcggc
     9601 gagcatacga cggcggtcct cgtcgggcag caggtaccag tcgtaactgc gcacgaaggg
     9661 gtacacgctg acgtagtcgc gcgcgacctc gtcggccagg aaggccggga tgtgcgactt
     9721 gttgaactcg gccgggcggt gcagggccat gttcgaccac accggctcca gcgcgcggcc
     9781 cagtcgggtg cggcggaaca ggttgtaggc ggtctgcagc tcgtccgccg tctcggcgtg
     9841 ccaccagatc atgacgtcgg cgtcggcgcg caggccggag acgtcgtagg tgccgcggac
     9901 ggtgatgtcc ttggcgccca gctggtcgaa gagctcctgg acctcgtcgg cgtagccggt
     9961 ccggtcctcg ggaagaacgt ccttcagctt gaagacggac cacagggtgt agcgaatgac
    10021 ctcattgagg tccttcgcct tcttccccgc gttgggaatc ttctctggtg cagtcatgtg
    10081 cctattgtcc cgtgcgctga tcagtggtcg gtgccagggg tgccgtacgc gcgcccagcg
    10141 cggcgatcac cgtgtccgcg gccctgccgg cgctcgcgat gcaggccgga atgcccacgc
    10201 cgtcgtagac ggcgccgcac accgcgaggc ccggcagggc cgcgacggcg ccgcggatcc
    10261 gggcgacgcg gtcgaggtgg ccgaccgagt actggggcag tccgccgtcc cagcgggtga
    10321 cggtggaggc gaccggccgg gccgccaggc cgacggcctc gccgaggtcg gcgagggaga
    10381 cgtcgacgag ctcgccgtcc tcgcgcagca ggatgctctc gtcggcgtag cggcccaccg
    10441 aggtgcgcag caggaagagt tccggatccg ctgccgccca ggcccacttg ttgctggaga
    10501 aggtggaggc cttgatggtg cggccgtcga cgggcggtac gaggaatccg ctggcgccgc
    10561 cgccggagac ggccgccggc aggtcgcggc ggcggaaggc catcgtgatc agggccatcg
    10621 aggcgtactc gaccccgcgc agctcggcgg ccgcggtcgg cgcgagcccg tccagcaggc
    10681 gcgcggcggc cccggccggg gtggccagga tcacggcgtc ggcctcgatg gcctcggcgc
    10741 cggcgaccac ccgccagccg tcggccgtac ggaggacctc gcggacgggg gcgccggtga
    10801 cgagccgcgc gccggctgcc cggcaggcct cggccacggc gagcgggagc cgtccgatgc
    10861 cgccgtcgat tccggcgaag accgggccgg gcggctgggg tgcggcctcg gcccggcgct
    10921 ggagttcgcg tactccgtcg ccgaggaggg cgtgggtgcg ggcggcctcg aagagctggg
    10981 gcacggcggc ccgcatggag atccgatagg cgtcgcccgc gtagacaccg ccgagcagcg
    11041 gttcgaccag ccggtcgacg acctcgcggc ccaggcgggc cgcgacgtac tcgccgacgg
    11101 cgacgtcctc gccgatctcg gtgggcgcca gcgtgcgctc ggcctcgatg cgggccaggc
    11161 cctcggcgga gagcaccccg gaggcggcga gcggtcccag gtcgccgggg acgcccatga
    11221 cgtggccgcg cggcatcggc cgcagtgcgc cgcgggtcca caggtgggcg gtggcggtgg
    11281 cgggcgcctg cacggatgcg ccgaggccga cggcctcggc gagcgccacg gcctcggggc
    11341 ggcgggcgag
//
