LOCUS       NZ_CP017717            27765 bp    DNA     circular CON 03-MAR-2024
DEFINITION  [Actinomadura] parvosata subsp. kistnae strain ATCC 55076
            chromosome, complete genome.
ACCESSION   NZ_CP017717
VERSION     NZ_CP017717.1
KEYWORDS    RefSeq.
SOURCE      [Actinomadura] parvosata subsp. kistnae
  ORGANISM  [Actinomadura] parvosata subsp. kistnae
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Streptosporangiaceae; Nonomuraea.
REFERENCE   1  (bases 1 to 13047416)
  AUTHORS   Nazari,B., Forneris,C.C., Gibson,M.I., Moon,K., Schramma,K.R. and
            Setedsayamdost,M.R.
  TITLE     Nonomuraea sp. ATCC 55076 harbors the largest actinomycete
            chromosome to date and the kistamicin biosynthetic gene cluster
  JOURNAL   Medchemcomm (2017) In press
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 13047416)
  AUTHORS   Nazari,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2016) Chemistry, Princeton University, 20
            Washington Road, Princeton, NJ 08544, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 18-JUN-2015
            Assembly Method                   :: Celera Assembler v. Jun 2015
            Assembly Name                     :: SmrtPipe 1.87.139483
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 110.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/03/2024 13:15:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 12,000
            CDSs (total)                      :: 11,919
            Genes (coding)                    :: 11,783
            CDSs (with protein)               :: 11,783
            Genes (RNA)                       :: 81
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 136
            CDSs (without protein)            :: 136
            Pseudo Genes (ambiguous residues) :: 0 of 136
            Pseudo Genes (frameshifted)       :: 36 of 136
            Pseudo Genes (incomplete)         :: 98 of 136
            Pseudo Genes (internal stop)      :: 10 of 136
            Pseudo Genes (multiple problems)  :: 6 of 136
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:57:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7666017
            Orig. end                         :: 7693782
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP017717.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..27765
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="26"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..27765
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27765
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:17765](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..17765)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            436..1974
                     /locus_tag="BKM31_RS34485"
                     /old_locus_tag="BKM31_34195"
     CDS             436..1974
                     /NRPS_PKS="Domain: AMP-binding (14-417). E-value: 1.5e-96.
                     Score: 315.5. Matches aSDomain:
                     nrpspksdomains_BKM31_RS34485_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634046.1"
                     /locus_tag="BKM31_RS34485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_34195"
                     /product="AMP-binding protein"
                     /protein_id="WP_230465512.1"
                     /sec_met_domain="AMP-binding (E-value: 4.9e-101, bitscore:
                     337.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGSMPDWGTLPRMLRDQAERHPGDVVVADPTGPRLTPAGLRAYAA
                     GVARGLMALGVEPGDRVALWGVNSPYWVGHAFGIWDAGAVLVPLSPRFKGIEAAQLLAK
                     TGAKVLVTGAGPAPAPLPGPLPELRHVVTPDGPGLAALGARVPARAAEERALAVRPDDL
                     CEIMSTSGTTGTPKGVMIDHSQVLRGYWDWSEIVTLDEHDRYPVIAPFSHGFGLNAGLV
                     ACVLRRATMIPVPVFTPDALMSLISEERATVLAGPPTLFHRLLDELDRDPGRSWDVSSL
                     RVAICGAAAVPAAMITRLVERVGLERMINAYGLMEGTVVSMTRAGDPIDVIANTTGRPV
                     PGIEVKIVDDDGKEVAPGERGEILQRGYGVMRGYWGEPERTAEVVDGDGWLHTGDVGVL
                     DEAGNLAIVDRKKDLYIVNGFNVSPAEVESLLLREGSLAQAAVVGVPDPSSGESGLAYV
                     VPRPGAAADPEALLAWARANMSGYKVPRRIVVLDALPTNANGKVDKVALRQHQA"
     aSDomain        478..1686
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BKM31_RS34485_AMP-binding.1"
                     /evalue="1.50E-96"
                     /label="BKM31_RS34485_AMP-binding.1"
                     /locus_tag="BKM31_RS34485"
                     /protein_end="417"
                     /protein_start="14"
                     /score="315.5"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="RDQAERHPGDVVVADPTGPRLTPAGLRAYAAGVARGLMALGVEPG
                     DRVALWGVNSPYWVGHAFGIWDAGAVLVPLSPRFKGIEAAQLLAKTGAKVLVTGAGPAP
                     APLPGPLPELRHVVTPDGPGLAALGARVPARAAEERALAVRPDDLCEIMSTSGTTGTPK
                     GVMIDHSQVLRGYWDWSEIVTLDEHDRYPVIAPFSHGFGLNAGLVACVLRRATMIPVPV
                     FTPDALMSLISEERATVLAGPPTLFHRLLDELDRDPGRSWDVSSLRVAICGAAAVPAAM
                     ITRLVERVGLERMINAYGLMEGTVVSMTRAGDPIDVIANTTGRPVPGIEVKIVDDDGKE
                     VAPGERGEILQRGYGVMRGYWGEPERTAEVVDGDGWLHTGDVGVLDEAGNLAIVDRKKD
                     LYIV"
     CDS_motif       931..984
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BKM31_RS34485_0001"
                     /evalue="1.40E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="BKM31_RS34485"
                     /protein_end="183"
                     /protein_start="165"
                     /score="23.9"
                     /tool="antismash"
                     /translation="IMSTSGTTGTPKGVMIDH"
     CDS_motif       1504..1584
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BKM31_RS34485_0002"
                     /evalue="1.10E-07"
                     /label="NRPS-A_a6"
                     /locus_tag="BKM31_RS34485"
                     /protein_end="383"
                     /protein_start="356"
                     /score="24.2"
                     /tool="antismash"
                     /translation="PGERGEILQRGYGVMRGYWGEPERTAE"
     CDS_motif       1657..1719
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BKM31_RS34485_0003"
                     /evalue="1.10E-03"
                     /label="NRPS-A_a8"
                     /locus_tag="BKM31_RS34485"
                     /protein_end="428"
                     /protein_start="407"
                     /score="11.8"
                     /tool="antismash"
                     /translation="VDRKKDLYIVNGFNVSPAEVE"
     CDS_motif       1801..1839
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BKM31_RS34485_0004"
                     /evalue="8.10E+01"
                     /label="NRPS-A_a3"
                     /locus_tag="BKM31_RS34485"
                     /protein_end="468"
                     /protein_start="455"
                     /score="-2.7"
                     /tool="antismash"
                     /translation="AYVVPRPGAAADP"
     gene            2008..3189
                     /locus_tag="BKM31_RS34490"
                     /old_locus_tag="BKM31_34200"
     CDS             2008..3189
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (7-388). E-value: 4.8e-59.
                     Score: 191.9. Matches aSDomain:
                     nrpspksdomains_BKM31_RS34490_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.4"
                     /locus_tag="BKM31_RS34490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_34200"
                     /product="class I adenylate-forming enzyme family protein"
                     /protein_id="WP_080042111.1"
                     /sec_met_domain="AMP-binding (E-value: 1.5e-59, bitscore:
                     201.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRLLAGEAARRFGGRAAVVTGSASLSFADLDRFSDQVAAGLAHR
                     GTRIGDVVVLALPDGPEFVICYLAAAKIGAVTAGIGVERLGLLTGLDPAIVITAPSVLP
                     PLSGLDVVTLPIDRGRRSPHLYDPVRLTGLRRPEPPPPPFPPDPARPVVITFTSGRTGP
                     PKGVVFGNRQLEAIRAHGAGLRWGTGDARLVPHPLGQLGFATRLPVILQTGRTCHVVAE
                     WTPDAVLRVLREHKIGVLQGTPHQLSRILDLREELPELSLILSSGAPATPALIRTLRTR
                     YGVPVCNRYICTEAGLGLGTRPDDPDEDAEFSVGRPRGSVNVSIRDAEGRALPAGDHGE
                     VLLRSEAVMSGYVGRSTDHAVFAKDGFIRTGDRGYIDHTGRLHLVGRVTRKPA"
     aSDomain        2029..3171
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BKM31_RS34490_AMP-binding.1"
                     /evalue="4.80E-59"
                     /label="BKM31_RS34490_AMP-binding.1"
                     /locus_tag="BKM31_RS34490"
                     /protein_end="388"
                     /protein_start="7"
                     /score="191.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="EAARRFGGRAAVVTGSASLSFADLDRFSDQVAAGLAHRGTRIGDV
                     VVLALPDGPEFVICYLAAAKIGAVTAGIGVERLGLLTGLDPAIVITAPSVLPPLSGLDV
                     VTLPIDRGRRSPHLYDPVRLTGLRRPEPPPPPFPPDPARPVVITFTSGRTGPPKGVVFG
                     NRQLEAIRAHGAGLRWGTGDARLVPHPLGQLGFATRLPVILQTGRTCHVVAEWTPDAVL
                     RVLREHKIGVLQGTPHQLSRILDLREELPELSLILSSGAPATPALIRTLRTRYGVPVCN
                     RYICTEAGLGLGTRPDDPDEDAEFSVGRPRGSVNVSIRDAEGRALPAGDHGEVLLRSEA
                     VMSGYVGRSTDHAVFAKDGFIRTGDRGYIDHTGRLHLVGRV"
     CDS_motif       2467..2514
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BKM31_RS34490_0001"
                     /evalue="1.80E-05"
                     /label="NRPS-A_a3"
                     /locus_tag="BKM31_RS34490"
                     /protein_end="169"
                     /protein_start="153"
                     /score="17.5"
                     /tool="antismash"
                     /translation="ITFTSGRTGPPKGVVF"
     CDS_motif       2791..2826
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BKM31_RS34490_0002"
                     /evalue="5.30E+01"
                     /label="NRPS-A_a3"
                     /locus_tag="BKM31_RS34490"
                     /protein_end="273"
                     /protein_start="261"
                     /score="-2.1"
                     /tool="antismash"
                     /translation="LILSSGAPATPA"
     misc_feature    3151..3153
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(3199..3209)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            3199..4500
                     /locus_tag="BKM31_RS34495"
                     /old_locus_tag="BKM31_34205"
     CDS             3199..4500
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1285: ferredoxin fdxC"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012888830.1"
                     /locus_tag="BKM31_RS34495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_34205"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_230465513.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 5.9e-09, bitscore:
                     35.0, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLHVAVIGSGPAGIYTAEALVKQSSEPVAVDVIERLPTPYGLVR
                     YGVAPDHTSIKSIANYLRKVLELPEVRFLGGVTLGRDVSVEDLLGLYDAVVYCTGAMVD
                     RRLGIPGEDLPGSVAATDFVNWYCGHPDVDPGRFTLDTSEVAVIGVGNVAVDVVRMLAK
                     AADELRSTDVPHEALQRLGESEVKAIHMVGRRGPEHAKFTLKELRELGELANADVCVRP
                     DEAAVLGGDFPRQVQGNIKVVREWAAREPVGRPRRLDVRFWLRPVEILGTERVEGLKLE
                     RTRLAEDGRVVGTGQFETLPVGMVLRSVGYQSVPLPGVPFSEKTMTVPNEAGRVRDREY
                     VAGWLKRGPTGVIGTNKSDAAETVRTLLADLDGGARAGSGGIDTLLAERGVRPVSYDDW
                     LAIEAAEAELARSLDRGERVKLVGLEAMLRAFRP"
     gene            4484..5641
                     /locus_tag="BKM31_RS34500"
                     /old_locus_tag="BKM31_34210"
     CDS             4484..5641
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020544360.1"
                     /locus_tag="BKM31_RS34500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_34210"
                     /product="aldolase"
                     /protein_id="WP_080042112.1"
                     /transl_table=11
                     /translation="MPSVPEPSVPGGFAETYRLQQARYPEQGPGWQPVHTVYVPADRFS
                     ARTVAEWGERALSLLKAHLAGPDEVAEVFDVPSGLAGVVHEMVLRKLSTEPVEDLRVDF
                     EDGYGVRPGPVEDGHVAQAVEAVAALHAAGALPRRWGPRVKSFADGDPARSVRTLHLFL
                     AGVVERVGELPGGFTVTFPKVLMEGYLGQFAQVLGELEAELGVRLRFEMQVEAPQTLPF
                     LRGDLNESLGGRLAAAHFGVFDYTAALGLPPHEQRLDHPACDHARHVMQTAFAGTGVEL
                     SDGSLAAAPASDRAGDVHGLWRRHAELVRHSLRHGFYQGWDMHPSHLVSRFATVYAFHL
                     ARYDSYRERVLAWEERRSAGGGVMDEPATIRTLAAALRRADAALP"
     gene            complement(5649..6329)
                     /locus_tag="BKM31_RS34505"
                     /old_locus_tag="BKM31_34215"
     CDS             complement(5649..6329)
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0055070 - copper ion homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020544359.1"
                     /locus_tag="BKM31_RS34505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_34215"
                     /product="copper homeostasis protein CutC"
                     /protein_id="WP_080042113.1"
                     /transl_table=11
                     /translation="MTGSLLEVIALDVRDAVAAEQGGADRLEIVADMAADGLTPAPETV
                     AAIAAECPLPQMVMLRCDAGFAADPDVVERLSRDAKELKQAGAAGFVFGFLDGAGAVDL
                     TATEALIHAVSPLPWTFHRAVDHAADVQAAWRAVRLLPNLATVLTSGAPTGVGDGLPVL
                     KARADAGDGSIVLAGGGLRPAHVPALLDYGIRAFHVGSAVRASWSDPVEWRLVRQWRAL
                     VERD"
     misc_feature    6292..6307
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
     gene            complement(6429..7646)
                     /locus_tag="BKM31_RS34510"
                     /old_locus_tag="BKM31_34220"
     CDS             complement(6429..7646)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017598979.1"
                     /locus_tag="BKM31_RS34510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_34220"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_080042114.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 9.3e-35, bitscore:
                     119.7, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGERYSVLRDMSGVRTASPLESARAGGPVPPQAPAAGSEPHVEVA
                     ELSKHELRDVARDPEVRAVAPVMPTTLVQPIEDAADGRAEAEAAAAAATWGVKAVGADV
                     TTRTGADTIVAVLDTGIDSAHPAFTGVTLIQEDFSGSGVGDKQGHGTHCAGTIFGRAVE
                     GTRIGVAPGVTRALIGKVLADDGSGDTEALLRGLEWALHQGAQVISMSLGFDFPGMVQR
                     LTDMGRQPRFATSLALEAYRANLRLFDALMRMVAARSAVGPGTVVVAAAGNESERQNGP
                     DFEIAVSLPAAAEGVIAVGALAQSPTGNGLVVAPFSNTFPQISAPGVGVVSARNGGGLR
                     SLSGTSMATPHVAGVAALWWEEVMRSPLPASASTVVARLLAGAVVSPLASGVDVADRGV
                     GLVRAP"
     gene            complement(7745..9760)
                     /locus_tag="BKM31_RS34515"
                     /old_locus_tag="BKM31_34225"
     CDS             complement(7745..9760)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017539.4"
                     /locus_tag="BKM31_RS34515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_34225"
                     /product="NACHT domain-containing protein"
                     /protein_id="WP_196223937.1"
                     /transl_table=11
                     /translation="MVGFATFVATVTSVVTLGSGVRQLLSWWREHRAPARAPTSADIDT
                     AKDILAGLVSEQWREETVLRSLGDPEPMPLPWRSTERRELVDHPGIIAKGAVAFPGLPM
                     HIKDMACGFRALPCRRLVILGGPGTGKTTLAVQLLLELLRTREPGERVPVLVSAARWDE
                     RVHPRLQDWLAAFLAMDYPALRAEALGPGIPEALAARGELLPVIDGLDELPDHARTDML
                     RALNRSLCENDELILTCRTEQFAESVDELGDVLTASAVIEPQPMDAVAAADYLEACLPP
                     VPRPAWSQVLHALRTGAAPALAQVTSTSLGLWLVRVTYIATRADPAPLLEYGKGSAAEL
                     HDHLCDELIPALVSARPPADGPAQPFRPQHAWTPEQVDRWLTYLCRELSASEVDTRDLA
                     WWHLARHISTWPVRWGSGIAVGAVVALVCAVLGGVPVVGVGFGVLSMLLIVLTTGSWFR
                     EAPGHADFHLRGMILGLVKALPAGILVGVLGAVIGWLTGTLLRDPHMGMTAARQVGLLS
                     GIGFVVVLSLVQWVERPATDASARSPRSTWLADRNLTAIRIAGGLAVGVIGAFVVWGTG
                     LSFPVGLACGLVGVLIGLLVGRHHAWLAYNLTVPRLATRGSLPLRAMNFLDDAHRLGLL
                     RTEGPYYQFRHVELQEHLARQLAEKKHRHREPVPLA"
     misc_feature    9772..9791
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.64"
                     /tool="antismash"
     misc_feature    complement(9892..9906)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.29"
                     /tool="antismash"
     gene            complement(10001..11206)
                     /locus_tag="BKM31_RS34520"
                     /old_locus_tag="BKM31_34230"
     CDS             complement(10001..11206)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.4"
                     /locus_tag="BKM31_RS34520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_34230"
                     /product="YcaO-like family protein"
                     /protein_id="WP_186404861.1"
                     /sec_met_domain="YcaO (E-value: 3.4e-41, bitscore: 141.5,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLAEAGRRSVAALAALGLRARLVDVGGGRDPAAWWCGLLDGTGS
                     APVASGMGKGALDEARLGALFEAIEHHLTGPACFDPDAVEPAAPAALAAGPLRADACAP
                     LLAPMPGRRMACRRYRALDGGDDALVPLFLSAPWYLEAGAAPLRERAGDDSDYTHLMRY
                     SCNSGSAVGVTAAEAVLHALNETIERDALSLLLVRAFLCGRPFRPRLVDPGTLPGPAAR
                     AYAVAAELTGSPVHLLDITTDLGAPSMLAYTAPACGRPHRRGTGTSLSPAHAAWRALTE
                     LVQTTLGEELGGGSRGDQAAPAAYPALAACGRFELTEVLRRGRVVPLPDGGPVMAAPGA
                     QLRAVCAMLAARGLRVYARTVRAVPGCVVAVHVMVPGLERFMLITDGNLVVPGPRASRA
                     VR"
     gene            complement(11244..11366)
                     /locus_tag="BKM31_RS64560"
     CDS             complement(11244..11366)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BKM31_RS64560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_268966889.1"
                     /transl_table=11
                     /translation="MGNVVDYVSVASLDRCDQHLTEAELARLEELTAAAGDEEG"
     misc_feature    complement(11445..11461)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.4"
                     /tool="antismash"
     misc_feature    11450..11463
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.91"
                     /tool="antismash"
     gene            11572..13626
                     /locus_tag="BKM31_RS34525"
                     /old_locus_tag="BKM31_34235"
     CDS             11572..13626
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012891707.1"
                     /locus_tag="BKM31_RS34525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_34235"
                     /product="serine protease"
                     /protein_id="WP_230465514.1"
                     /transl_table=11
                     /translation="MMEISTEVGESRVRQTRAAAERYRWSGSERDEAWRRRERGEAFPD
                     SPEMLAARTARLIQRNGLPVEAALEATRTDALDQPQMYERILGVAKDLQSWSFLPRGAR
                     AARTVARICVAENGREIPIGTGFLVSPRLLLTNHHVLPDATAAASVIVEFDAQVTVDNT
                     PEVSRRFVLAPEVFFVADSALDFALVLVRPDADGRQAGDTFGWNRLSVQTGKLVIGEPV
                     NIIGHPSGRLKEISIRENRLEARLDEFLHYQTDTEPGNSGSPVYNDQWEVTALHHSGVP
                     RTDDQGRILRRDGQPWREGDGDDAVDWVSNEGVRISVILKHLAALPLDEARRACLTEMG
                     PESGLGAVTVPPPAPPMDERPAVEPGPLATTPRTGLPAAPGAFGGSRHVVFLHGRGQEE
                     GVPEVLRRNWAAGLNGGLTRAGLPTIEPADVCFPYYAHRLLQAMRPVEALPHPPHGAVE
                     AVAPAPGSTRRLYEQLIVEAAGRAGLPGAGPGSAEGLGDSVRRGLNWLADTTDLDRLFI
                     AAVFADVAAYLDDQGVREAVVDCVLGEMPQTGRLVLVSHSLGTVVAMDLLTRLDPAVEV
                     ELLVTAGSPLGLDGVHRRLLTGGPRRPGRVTRWFNAWCPIDPVALGCPLGDRWTDGPEE
                     VAVANPVGQAHDIDEYLAHPEVAQPIGAALHAAAPVAGAGSAAYGGATP"
     gene            13623..14666
                     /locus_tag="BKM31_RS34530"
                     /old_locus_tag="BKM31_34240"
     CDS             13623..14666
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BKM31_RS34530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BKM31_34240"
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_222107917.1"
                     /transl_table=11
                     /translation="MTNLKVATVNGEWMNDWFTADAETAAFVPTFSKDGEHGVTAQAAG
                     RLAGLISALDADIVALVEAPSRPAELKLFIDEYLSENGRPAYDFVLGDSGGSQKLALLF
                     KPGRVALSLTPSSEAGPFIDPWLADVDGDGTLNEYAFTRNPLCCGADVDGGRLGVVVAH
                     LKSNFINRGRQLWQDPARRLEFVRAALRNRRRIANEAMRIRRAMERRLATEPEAAIIVL
                     GDLNDGPGQDYFEEFYLAHNVTDILVGSPYQPERLFGHAQADVEEERRFSAVFDDFVTK
                     EPNRHVLLDHILLSPAMTHGGAPLTKVPGSGRVEHDAWAAQLDGDGSARDRRATDHRPV
                     SVLLTPA"
     gene            complement(14653..16380)
                     /locus_tag="BKM31_RS34535"
                     /old_locus_tag="BKM31_34245"
     CDS             complement(14653..16380)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014794.4"
                     /locus_tag="BKM31_RS34535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_34245"
                     /product="thiamine pyrophosphate-binding protein"
                     /protein_id="WP_080042117.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2.4e-40, bitscore:
                     137.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1e-31, bitscore:
                     109.2, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVYEAIVAGLEDVGVEAAFGGAGENAAGLMLALKHSRRIRPIIT
                     RHEQAASFMACGYAMFSGKLGFCFATAGPGAFNLFSGLAMAMSDSYPVLAVSGYAPRKW
                     QGWGSLNETSGLGGTPDSRAMFAATTKKSFLLESAEDTFDVLEEAVNRAFEGRPGPVHI
                     HVPLDLTERGVEVRNRRPVRLDVAPVPPDPARVEEIASVLADALARRRRIVVLAGFGAV
                     RSGAGPQIKRLVERFQIPLLTTLDGKGIVSETHPLALGVFSDSGHASAWKAFREADVVL
                     CVGNSLNQHATFGYRQDLFDGKLLIHVNICENEFRKAYPPDHALLSDARPAVAALADAL
                     ERKVGDVPAADVTGKDYESRHITHLTGRIHPGELAQAIGRLLPAGAVLLADAGAHLAWL
                     GYYVEVEEGQNFRKAGSFGPMAGHVNGAIGVKVAHPDRTVVVGCGDGCYALSGFELMTA
                     VEHDIPVIWIIFDDQEFKLIKLYQLAAYRESGLVEFRNPDFAAYARACGADGHRVETIE
                     EFESAFRSALGSGRPTVIDARITRWAVPHYSPSPHGVIAGLVEAVEERLRGRDDVRRE"
     gene            complement(16377..17765)
                     /locus_tag="BKM31_RS34540"
                     /old_locus_tag="BKM31_34250"
     CDS             complement(16377..17765)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BKM31_RS34540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BKM31_34250"
                     /product="hypothetical protein"
                     /protein_id="WP_080042118.1"
                     /sec_met_domain="PF00881 (E-value: 0.0002, bitscore: 20.9,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVKPATRQEGLEALLARPLLETIWKRRTHRVSRGASVPAGSMSY
                     RSPHPPMPLTELEEALLIALTGCSGLTMPDRPFEDPRDGDPIMAKPNLTMAGRTAGSPD
                     NAQGTHFFMINDTGTYYLRKLPPAAALPFTAEALIERARQAKVRVLSHRLDVAEGRRDF
                     PAYLDANRFLSNLPGSTIFLPVVDLSHQYINCLMFLLTQPEGARPTFVDDRNLYRPAGV
                     AKWVKNGFLNPDVKVPLGAMGTMRVQIEADLLMQNLMLTADAMGLGAWIHGTIHPQIML
                     GDPKFSRAYGRMLGFDFVTPRFRLADVLRWHVPLPRYATLRSHPVGLRVNGEQLIRAAC
                     PPNFPSMEAAVDHVVRAKFGPGGIYTDEATFARIYKGDYGRRYLAEASAYEQEVIDCAR
                     DVCVYIHETHGRFPAHADAIHVPGIWLQTHHVETEYYERFFADGTTDAHRRHDARWHGD
                     GARQ"
     gene            complement(17779..20694)
                     /locus_tag="BKM31_RS34545"
                     /old_locus_tag="BKM31_34255"
     CDS             complement(17779..20694)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015083.4"
                     /locus_tag="BKM31_RS34545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_34255"
                     /product="peroxidase family protein"
                     /protein_id="WP_080042119.1"
                     /transl_table=11
                     /translation="MAKQQERVVRERPAARERPTSERYERYVGGSPEAERVILQRLADD
                     LMRVQLKIKERGGASGIDRTFHAKAILGVENATLRFHDSLPQELRTGFAQPGAEYPVII
                     RLSNASGARRPDPAPDLRGAALRIQAGDGEAHDLLMTNHPVSHAANAREFVVFARVMAG
                     ADTTVRRALALYVRLPWALGWATAARMRRNVLAGARREVRSLALETYWSRSAILWGEAG
                     PVRYRLRPAAVSPAVPAPPPWDADHLSHELAARLARQDIVFELCVQRYEDARLTPIENG
                     AADWPDADVPVVPVATLTIPRQDLGTAAARAAAARIDQLAFDPWNTTDAFRPLGNLNRA
                     RKAAYKASSAHRRGRRFVTPTPRRNVVAGALLRGAFGALNRFVPWHRLPTWIGLLNVAT
                     IRQVLRRENLFDTEVRQAPPRPHPVPPALDESLLVRRTYDGTYNDLSDPAMGALGATFG
                     RNLRPVHRPDLFDEPNPVVVSRELLHRDSFIPARSLNVIAAAWIQFQVHDWVDHKRCPA
                     GAGSVEVPLPYGMTWTNTPGGAPERVMRFADNEDLRPAGGTGPPILSANAASHWWDGSE
                     VYGGDESVAKSLREPDGDASLRLENGHLVPGPDGIPITGFRNNWWLGLSVMHTLFAREH
                     NAVCRALREEYPGMDEESVYHTARLVVSALIAKIHTVEWTPAILATELIDIGLKANWQG
                     PPKSWLTHLGLWLADAHALTGIPGTLPDHHGTPYSLTEDFVTVYRMHPLIPDDYELADH
                     RTGRRLESLGFHDLQGAATEPVMRRTGLANALYSLGIAHPGAITLRNFPRALQAFEREG
                     EIIDLSVVDLVRTRRRAVPRYNDFRAGLHRPRLRRFEDLTTNPDCLARLRDVYRSVDDI
                     DTMVGLFAENPPERFGFSDTAFRIFILMASRRLQSDRFLTVDFRPEIYTPLGMDWVARN
                     GMTSVILRHCPGLAAVLPRTTSAFAPWRPARPEANTGTTPD"
     misc_feature    20803..20814
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.7"
                     /tool="antismash"
     gene            complement(20905..21507)
                     /locus_tag="BKM31_RS34550"
                     /old_locus_tag="BKM31_34260"
     CDS             complement(20905..21507)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020544358.1"
                     /locus_tag="BKM31_RS34550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_34260"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_080042120.1"
                     /transl_table=11
                     /translation="MHTNTLLHPLSLRRAEPADLPGVLTLLADTAEWLHAQGVRQWPRG
                     GFGPERIEPLIEERVLFLLDDELRYLDPDEAAPPVATIALDDHADPEFWTPADDPGAAL
                     YIHKLAVARPWSGSGLGDALLDWACASAYSAGLPWLRLDCAKANPRLQGYYRDRGFRHV
                     RTVDLPHRSSGALFQRPSEDVPITVFRDLTVAELISA"
     misc_feature    complement(21543..21556)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.03"
                     /tool="antismash"
     misc_feature    complement(21599..21612)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.9"
                     /tool="antismash"
     gene            complement(21711..22448)
                     /locus_tag="BKM31_RS34555"
                     /old_locus_tag="BKM31_34265"
     CDS             complement(21711..22448)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020544357.1"
                     /locus_tag="BKM31_RS34555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_34265"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_080042121.1"
                     /transl_table=11
                     /translation="MLYQQVASELRRAIYSGVLGPGAQLPTEAQLMEDHGVSRNTVRLA
                     LGELVNEGLVTRTPRRGTVVRDRRPLLIYPQRELEPQPSGELREAFAYAVGQEGRAPSQ
                     YIEVLTVSPVEEIASRLELADGELAVVRRRLRFVDGQPYNTNDSYFPRDLVADSEIARP
                     GDIARGANRVLEELGHAQVRVVDDIWARMPNQEEAERLQLELGTPVMVYVRVGYDGADM
                     PVRVAVSVLPADKHLIRYELDRR"
     misc_feature    22470..22483
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.13"
                     /tool="antismash"
     misc_feature    complement(22471..22484)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.58"
                     /tool="antismash"
     misc_feature    22471..22485
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.51"
                     /tool="antismash"
     misc_feature    22887..22902
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.59"
                     /tool="antismash"
     gene            complement(23261..23695)
                     /locus_tag="BKM31_RS34560"
     CDS             complement(23261..23695)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020544356.1"
                     /locus_tag="BKM31_RS34560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="WP_080042122.1"
                     /transl_table=11
                     /translation="MPGYRPEPDRDSRAWWDRLARHEFAVQECDACGTLRFPPRAFCAA
                     CRQEGWHWRETVPEGTVESWIVSRQPFVPGHRDPYLVVMVRLTAVPGALVYGNWRAERQ
                     PEAGERVRGTFTQVDEELTVLDWAPESRIAIRSGENSPVR"
     gene            complement(23695..24858)
                     /locus_tag="BKM31_RS34565"
                     /old_locus_tag="BKM31_34270"
     CDS             complement(23695..24858)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020544355.1"
                     /locus_tag="BKM31_RS34565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_34270"
                     /product="acetyl-CoA acetyltransferase"
                     /protein_id="WP_230465515.1"
                     /transl_table=11
                     /translation="MPKRLLEFTDRTAIAGVGYTPFSKDSGVSTLTLACRAVLAALEDA
                     GLTPDEVDGLATHRVGDSAPPTLVGPALGLSDLSWHLDQFGGGSVSHAVVGQAALAVAA
                     GLAEVVVCYRAINARSEFRMGGTGRGLPASPEVQYQAPYGYVAPPQQFAMYARAHMLRY
                     GTTAEHFGALAVTQRANAAKNPRALMRTPITLDDYLASRWIAEPFRLLDCCLETDGACA
                     VVVTTAERARSLRRHPVLVSAAAWGGGTSHLSCDDPTVTAAAALAPRLYAQAGVGPADI
                     DVAELYDCFTYSVIVQLEDYGFCPKGEGGPYVASGATALDGALPVNTHGGFLSEGYVHG
                     VNHIAEAVSQLRGEAGDRQVPGAEVALSTAQPGYVLPATSALILRRA"
     misc_feature    complement(24840..24853)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.89"
                     /tool="antismash"
     misc_feature    24916..24931
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.96"
                     /tool="antismash"
     misc_feature    complement(24947..24960)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.89"
                     /tool="antismash"
     gene            25092..25613
                     /locus_tag="BKM31_RS34570"
                     /old_locus_tag="BKM31_34275"
     CDS             25092..25613
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160: flavin reductase domain protein FMN-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020544354.1"
                     /locus_tag="BKM31_RS34570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_34275"
                     /product="flavin reductase family protein"
                     /protein_id="WP_080042123.1"
                     /transl_table=11
                     /translation="MPTGHSQHSQNGQLDSRRFRQVLGRFATGVVAITAVDPMDGQPCG
                     LAANSFTSVSLDPPLIAFCVAYTSTSWPRLRGAKAMTVNVLAEHQQAVCAQLATKGGDK
                     FAGLAWTVSPGGNPVLEGALAWLDCAVEAEHPAGDHLIVVARVLQLDTYAEGGPLVFFR
                     GGYGGFVEPS"
     gene            25600..26727
                     /locus_tag="BKM31_RS34575"
                     /old_locus_tag="BKM31_34280"
     CDS             25600..26727
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012888821.1"
                     /locus_tag="BKM31_RS34575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_34280"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_080042124.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.1e-19, bitscore:
                     69.7, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 7.6e-23, bitscore:
                     80.0, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.2e-26, bitscore:
                     93.2, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLREEARAWLEESLSGEFAGARGLGGPGREHEAYELRRAWERHL
                     GAHGWTCLGWPRRYGGRAASIGDQVAFHEEYARAGAPARLGLIGEGLIGPTILDFGTAE
                     QKDRFLPPIQRGDELWCQGYSEPEAGSDLAGVRTRARLEGGEWVITGQKVWTSLAQWAD
                     WCFALCRTEEGSQRHRGLSYLLVPMRQPGVEVRPIVQLTGTSEFNEVFFDGARTAAGNI
                     LGAPGDGWRVAMATLGYERGVSTLGQQIGFRRELAEVIAAARRTGAIDDPVLRDRLVRS
                     WLELEIMRLNALRVLRPDPGPEASITKLYWSEWHRRLGELAQAVQGRAGLVAGDDGTLG
                     ELQRLYLFSRADTIYAGSSEIQRTVIAERTLGLPR"
     gene            26753..27526
                     /locus_tag="BKM31_RS34580"
                     /old_locus_tag="BKM31_34285"
     CDS             26753..27526
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (15-177). E-value: 7.5e-13.
                     Score: 40.7. Matches aSDomain:
                     nrpspksdomains_BKM31_RS34580_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020544352.1"
                     /locus_tag="BKM31_RS34580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_34285"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_080042125.1"
                     /sec_met_domain="adh_short (E-value: 2.4e-33, bitscore:
                     115.0, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 1.2e-32, bitscore:
                     113.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPPYPKAHGLLDGKVTLVTAAAGAGIGYATARRCAEEGATVVLS
                     DRHERRLAAAAESLAELTGVKPLAVPCDVTAQAQVAELFEAVVRAHGRLDVLVNNAGLG
                     GTAELAGMTDEQWHAVVDVTLTGTMRCTRAALGHMIPQGGGAIVNNASVVGWRAQRGQA
                     HYAAAKAGVMALTRCVAMEAAEHGIRVNAVAPSLAVHPFLAKVTSEELLAELAAKEAFG
                     RSAEPWEVANVIVFLASDYASYMTGEVVSVSSQHP"
     aSDomain        26798..27283
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BKM31_RS34580_PKS_KR.1"
                     /evalue="7.50E-13"
                     /label="BKM31_RS34580_PKS_KR.1"
                     /locus_tag="BKM31_RS34580"
                     /protein_end="177"
                     /protein_start="15"
                     /score="40.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VTLVTAAAGAGIGYATARRCAEEGATVVLSDRHERRLAAAAESLA
                     ELTGVKPLAVPCDVTAQAQVAELFEAVVRAHGRLDVLVNNAGLGGTAELAGMTDEQWHA
                     VVDVTLTGTMRCTRAALGHMIPQGGGAIVNNASVVGWRAQRGQAHYAAAKAGVMALTR"
     misc_feature    27536..27552
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.58"
                     /tool="antismash"
     misc_feature    27641..27656
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.44"
                     /tool="antismash"
ORIGIN
        1 ccgggcactc gacgctcggt gacgccgtgc tcaggacggg cctggtggcc gcgccggcgg
       61 cggccggagc gatcccggcg cccgcgcaca cggtcggcga gcacgtgctc gtcaggggcg
      121 tgtggctggc gctgccgcgc atcgacaggg cgctggcccg cgtcgacggc gtggccgggt
      181 gggagctggc gatcagccgg caggggacgc tggacacggc ggtgctcacg gtggcgttcg
      241 cgcggcgcag cctgatcggc aaccccatgt ggaaggcgcg gatcgagcag gcggtgcggg
      301 cgctgacccc cgtgtcggtc gcggtggaga tcgcccagga cgtcgccgag accccctccc
      361 ccggcgtcgt gaacgacctg cgcggccacc acctcggaag ggaccgggcg ctcatcacct
      421 gagaaggggc tgccgatggg atcgatgccg gactggggga cgctcccccg catgctgcgt
      481 gaccaggccg agcgccatcc cggcgacgtc gtggtggccg atcccaccgg cccgcggctc
      541 acgccggccg ggctgcgcgc ctacgcggcc ggggtcgccc gcggtctcat ggcgctcggg
      601 gtggagcccg gtgaccgggt ggccctgtgg ggggtgaact cgccgtactg ggtggggcac
      661 gcgttcggga tctgggacgc gggcgcggtg ctcgtgccgc tgtcgccgcg cttcaagggg
      721 atcgaggcgg cgcagctcct cgcgaagacc ggcgcgaagg tgctggtcac cggcgcgggc
      781 ccggccccgg cgccccttcc cgggccgctg cccgagctgc ggcacgtcgt cacgccggac
      841 ggccccgggc tggccgcgct cggcgcgcgg gtccctgccc gcgcggccga ggagcgggcg
      901 ctcgccgtcc gtccggacga cctgtgcgag atcatgtcca cctccggcac caccggcacc
      961 cccaagggcg tgatgatcga ccactcgcag gtgctgcgcg gctactggga ctggtcggag
     1021 atcgtcaccc tggacgagca cgaccgctac ccggtgatcg cgccgttcag ccacgggttc
     1081 gggctgaacg cggggctggt ggcctgcgtg ctgcgccggg ccacgatgat cccggtcccg
     1141 gtcttcaccc cggacgcgct gatgtcgctc atctccgagg agcgggccac ggtgctggcc
     1201 gggccgccca cgctgttcca ccggctgctg gacgagctgg accgcgatcc cgggcgctcc
     1261 tgggacgtgt cgtcgctgcg ggtggccatc tgcggggccg ccgccgtccc tgccgccatg
     1321 atcacgcggc tggtcgagcg ggtcgggctg gagcgcatga tcaacgcgta cgggctcatg
     1381 gagggcacgg tcgtctccat gaccagggcg ggcgacccca tcgacgtgat cgcgaacacc
     1441 accggccggc ccgtcccggg catcgaggtg aagatcgtgg acgacgacgg caaggaggtc
     1501 gcgcccggcg agcgcggcga gatcctgcag cgcggctacg gcgtgatgcg cggctactgg
     1561 ggcgagcccg agcgcacggc cgaggtggtc gacggcgacg gctggctgca caccggcgac
     1621 gtcggcgtgc tggacgaggc gggcaacctg gccatcgtgg accgcaagaa ggacctctac
     1681 atcgtcaacg ggttcaacgt ctcccccgcc gaggtcgagt cgctgctgct gcgggagggc
     1741 tcgctggcgc aggccgcggt cgtgggcgtg ccggacccgt cgtccggcga gtcgggcctg
     1801 gcgtacgtcg tgccccggcc gggggcggcg gccgacccgg aggcgctgct ggcgtgggcg
     1861 cgcgccaaca tgtccggcta caaggtgccc cggcggatcg tcgtgctcga cgcgctgccg
     1921 accaacgcca acggcaaggt ggacaaggtc gccctgcggc agcaccaggc gtagcgtggg
     1981 aggcaggccc ttcgcccagg agccgccatg ctgcgcctgc tcgccggtga ggccgcacgc
     2041 aggttcgggg ggcgcgcggc cgtcgtcacc ggctccgcct cgctgtcctt cgccgacctc
     2101 gaccgcttct ccgaccaggt cgccgccggg ctcgcccatc gcggcacccg catcggcgac
     2161 gtcgtggtgc tggcgctgcc cgacgggccc gagttcgtga tctgctacct ggcggcggcg
     2221 aagatcggcg cggtcacggc gggcatcggc gtcgagcggc tgggcctgct gaccggcctc
     2281 gacccggcga tcgtgatcac cgcgccgagc gtgctgccgc cgctgtccgg gctggacgtg
     2341 gtgacgctgc ccatcgaccg tggccgccgc tcgccgcacc tgtacgaccc ggtccggctc
     2401 acgggcctgc gccggcccga gccgcccccg ccgccgttcc cgccggatcc cgcccggccg
     2461 gtcgtgatca cgttcacgtc gggcaggacg gggccgccga agggcgtggt gttcggcaac
     2521 cggcagctgg aggcgatccg cgcgcacggc gccgggctgc ggtggggcac gggcgacgcc
     2581 aggctggtgc cgcatccgct ggggcagctc gggttcgcca cccggctgcc cgtgatcctg
     2641 cagacggggc gtacctgcca cgtcgtggcc gagtggacgc ccgacgcggt gctgcgggtg
     2701 ctgcgcgagc acaagatcgg ggtgttgcag ggcaccccgc accagctctc ccgcatcctc
     2761 gacctgcgcg aggagctgcc ggagctgtcg ctcatcctgt ccagcggcgc ccccgccacg
     2821 ccggcgctga tcaggacgtt gcgcaccagg tacggcgtgc ctgtctgcaa ccgctacatc
     2881 tgcacggaag ccggtctggg gctcggcacg cgtcccgacg acccggacga ggacgcggag
     2941 ttcagcgtgg gcaggccgcg cggcagcgtg aacgtctcga tcagggacgc cgagggccgc
     3001 gccctgcctg ccggggatca cggtgaggtg ctgctccgct cggaagcggt catgagcggt
     3061 tacgttggca ggagcaccga tcatgcggtg ttcgccaagg acgggttcat ccgcaccggc
     3121 gaccggggat acatcgatca cactggccgg ttacatctgg tgggacgggt cactcgtaaa
     3181 ccggcgtagg gaggcggcgt gacgttgcac gtggcggtca tcgggtcggg ccctgccggg
     3241 atctacacgg ccgaggcact ggtcaagcag tcgtcggagc cggtcgcggt cgatgtgatc
     3301 gagcgactgc cgaccccgta cgggctggtc cggtacggcg tggcgcccga ccacacctcg
     3361 atcaagtcga tcgcgaacta tctgcgcaag gtgctggagc tgccggaggt gcgcttcctc
     3421 ggcggcgtca cgctcggccg ggacgtgtcg gtcgaagacc tgctcggcct ctacgacgcg
     3481 gtcgtctact gcacgggcgc gatggtcgac aggaggctcg gcatccccgg ggaggacctt
     3541 ccgggcagtg tggccgcgac cgacttcgtc aactggtact gcggccaccc cgacgtcgat
     3601 cctggccggt tcacgctcga cacctccgag gtggccgtga tcggggtcgg gaacgtcgcc
     3661 gtggacgtcg tccgcatgct ggccaaggcc gccgacgagc tgcgctccac cgacgtgccg
     3721 cacgaggcgc tgcagcggct cggcgagagc gaggtgaagg ccatccacat ggtggggcgg
     3781 cgcgggcccg agcatgccaa gttcaccctc aaggagctgc gcgagctggg cgagctggcc
     3841 aacgccgacg tgtgcgtgcg ccccgacgag gccgccgtcc tcggcggcga cttcccgcgc
     3901 caggtgcagg gcaacatcaa ggtcgtgcgg gagtgggcgg cccgcgagcc ggtcggccgg
     3961 ccgcgccgcc tcgacgtgcg cttctggctg cggcccgtcg agatcctcgg cacggagcgg
     4021 gtcgaggggc tgaagctcga acgcacccgc ctggcggagg acggccgcgt ggtcggcacc
     4081 ggccagttcg agacgctgcc ggtcggcatg gtgctgcgct cggtcggcta ccagagcgtc
     4141 ccgctgcccg gcgtgccctt ctccgagaag acgatgacgg tgccgaacga ggccgggcgc
     4201 gtgcgcgacc gcgagtacgt cgcgggctgg ctcaagcgcg ggccgaccgg ggtgatcggc
     4261 accaacaagt ccgacgcggc ggagaccgtc cgcaccctgc tcgccgacct cgacggcggc
     4321 gcgcgggccg gctcgggcgg catcgacacg ctgctggccg agcgcggggt ccggccggtg
     4381 agctacgacg actggctggc catcgaggcg gccgaggcgg agctcgcccg ctcgctcgac
     4441 cgcggcgaac gcgtcaagct cgtcggtctg gaggccatgc tccgtgcctt ccgtccctga
     4501 gccctccgtt cctgggggct tcgcggagac gtaccggctg cagcaggccc gctaccccga
     4561 gcaggggccg ggctggcagc cggtccacac cgtgtacgtg ccggccgacc gcttctccgc
     4621 ccgcacggtc gccgagtggg gcgagcgggc gctgtcgctg ctcaaggcgc acctggcggg
     4681 ccccgacgag gtggccgagg tgttcgacgt gccgtccggg ctggccggcg tggtgcacga
     4741 gatggtcctg cgcaagctgt cgaccgagcc ggtggaggac ctgcgcgtcg acttcgagga
     4801 cggctacggc gtgcggccgg gccccgtcga ggacggccac gtggcgcagg ccgtcgaggc
     4861 ggtcgccgcg ctgcacgccg ccggggcgct gccgcgccgc tgggggccgc gggtgaagtc
     4921 gttcgccgac ggggacccgg cgcggtcggt gcgcacgctc cacctgttcc tggcgggggt
     4981 ggtggagcgg gtgggcgagt tgcccggcgg gttcacggtg accttcccca aggtgctcat
     5041 ggagggctat ctcgggcagt tcgcgcaggt gctgggcgag ctggaggcgg agctcggggt
     5101 ccggctgcgg ttcgagatgc aggtggaggc gccgcagacg ctgccgttcc tgcgcggcga
     5161 cctgaacgag tcgctgggcg ggcggctggc ggcggcgcac ttcggcgtct tcgactacac
     5221 ggccgcgctg gggctgccgc cgcacgagca gcggctcgac catccggcct gcgaccacgc
     5281 gcggcacgtc atgcagacgg cgttcgcggg cacgggggtg gagctgtcgg acgggtcgct
     5341 ggccgccgcg cccgcctccg atcgcgcggg cgacgtgcac gggctgtggc ggcggcacgc
     5401 cgagctggtc cgccactcgt tgcggcacgg cttctaccag ggctgggaca tgcatccgtc
     5461 gcacctggtg agccggttcg ccaccgtcta cgccttccac ctggcgcgct acgactccta
     5521 ccgggagcgg gtgctggcct gggaggagcg gcgctcggcc gggggcggcg tgatggacga
     5581 gccggccacg atccgcaccc tggccgcggc cctgcgccgc gcggacgccg ccctgccgtg
     5641 acgcgcgctc agtcgcgttc gacgagggcg cgccactggc ggaccaggcg ccactcgacc
     5701 gggtccgacc agctcgcccg caccgccgag ccgacgtgga aggcgcggat gccgtagtcg
     5761 agcagggccg gcacgtgcgc gggccgcagg ccgccgccgg cgagcacgat ggagccgtcg
     5821 ccggcgtcgg cgcgcgcctt cagcacgggc aggccgtcgc cgacgccggt gggcgcgccg
     5881 gaggtgagca cggtggcgag gttcggcagc agccgcacgg cccgccaggc ggcctggacg
     5941 tcggcggcgt ggtccacggc gcggtggaac gtccacggca gcggcgagac cgcgtggatg
     6001 agcgcctccg tggcggtcag gtccaccgcc cccgcaccat cgaggaagcc gaagacgaac
     6061 ccggccgcac ccgcctgctt cagctccttg gcgtcgcggc tgagccgctc gacgacgtcg
     6121 gggtcggcgg cgaagccggc gtcgcagcgc agcatcacca tctggggcag ggggcactcg
     6181 gcggcgatgg cggcgaccgt ctccggtgcg ggcgtcagcc cgtcggccgc catgtctgcc
     6241 acgatctcca ggcggtcggc tccgccctgt tcggcggcca cggcgtcgcg cacgtcgagc
     6301 gcgatcacct cgagcaggga tccggtcatg caggagaggt tatatggcgc tttgcgcact
     6361 tgtgccagag agttgacctc agcacgcacc ccggacgggg aacgaccggc ccgcggaacg
     6421 cccggcgatc acggggcgcg caccagcccg acgccccggt cggccacgtc cacgccggag
     6481 gccagggggc tgaccaccgc accggccagc aggcgcgcga cgacggtgga cgcgctcgcc
     6541 ggcagcggcg acctcatcac ctcctcccac cacagcgccg ccacgcccgc gacgtgcggc
     6601 gtggccatgc tcgtgccgct cagcgaacgc aggccgcccc cgttccgcgc cgagaccacg
     6661 cccacgccgg gcgcgctgat ctgcgggaag gtgttggaga acggcgccac gaccagcccg
     6721 ttgcccgtgg gcgactgcgc cagcgcgccc accgcgatga cgccctccgc cgcggccggc
     6781 agcgacacgg cgatctcgaa gtccggcccg ttctgccgct cgctctcgtt ccccgccgcc
     6841 gccacgacca cggtgccggg cccgaccgcc gagcgcgccg ccaccatccg catgagcgcg
     6901 tcgaagagcc gcaggttcgc ccggtacgcc tccagcgcca gcgacgtggc gaacctgggc
     6961 tgccgcccca tgtcggtcag ccgctgcacc atgccgggga agtcgaaccc cagggacatc
     7021 gagatcacct gggcgccctg gtgcagcgcc cactccaggc cgcgcagcag cgcttcggtg
     7081 tcgccgctcc cgtcgtcggc gagcaccttg ccgatcagcg cccgggtcac gcccggggcg
     7141 acgccgatgc gcgtgccctc gaccgcccgg ccgaagatcg tgcccgcgca gtgcgtgccg
     7201 tgcccctgct tgtcgcccac gcccgagccg ctgaagtcct cctggatgag ggttaccccg
     7261 gtgaaggcgg ggtgggcgga gtcgatgccg gtgtcgagga cggccacgat cgtgtccgct
     7321 cccgtcctcg tcgtgacgtc ggcgcccacg gccttgacac cccacgtcgc cgcggcggcg
     7381 gccgcttcgg cctccgcccg cccgtcggcc gcgtcctcga tcggctggac gagcgtggtg
     7441 ggcatgaccg gcgccaccgc ccgtacctcc ggatcgcgtg cgacgtcgcg cagctcgtgc
     7501 ttgctgagct cggccacctc cacgtgcggc tcgctgccgg cggccggcgc ctgcggcggc
     7561 acggggccgc ccgcccgcgc cgactccagc ggactcgccg tgcgcacgcc gctcatgtcg
     7621 cgcagcacgc tgtatctctc acccatggcc ttctcctccc ctcggtcctc cggccccctc
     7681 gggaacagtg ccctggccgg ttccaccggc ggccaagccg cggtgaaatg ccccccaaca
     7741 gggctcaggc gagcggtacc ggctcccggt gccgatgctt cttctccgcg agctggcggg
     7801 ccaggtgctc ctgcagctcg acgtgccgga actggtagta cggcccctcc gtacgcagca
     7861 ggccgaggcg gtgcgcgtcg tccaggaagt tcatcgcccg cagcggcagg ctgcccctgg
     7921 tggccaggcg cggcacggtg aggttgtagg ccagccaggc gtggtggcgg cccaccagca
     7981 gcccgatcag cacgcccacc aggccgcacg cgaggcccac agggaagctg agccccgtcc
     8041 cccacacgac gaacgccccg atgacgccga ccgcgagccc gccggcgatc ctgatggccg
     8101 tcaggttgcg gtcggccagc caggtcgagc gcggagagcg cgcgctggcg tccgtggccg
     8161 gccgctcgac ccactggacc aggctgagca cgacgacgaa cccgatgccc gacagcagcc
     8221 cgacctgtct cgcggccgtc atgcccatgt gcgggtcccg cagcagcgtg cccgtcagcc
     8281 acccgatgac cgcgcccagg acgccgacga ggatccccgc gggcagcgcc ttgaccaggc
     8341 cgaggatcat gccacgcaga tggaagtccg cgtgccccgg cgcctccctg aaccaggagc
     8401 cggtcgtgag cacgatcagc agcatcgaca gcacgccgaa ccccacgccg acgaccggga
     8461 cgccgcccag gacggcgcag accagggcca ccacggcccc gaccgcgatg ccgctgcccc
     8521 accgcaccgg ccaggtggag atgtggcggg ccaggtgcca ccacgccagg tcccgcgtgt
     8581 ccacctcgct cgcggacagc tcgcggcaca ggtacgtcag ccagcggtcc acctgctccg
     8641 gcgtccacgc gtgctgcggg cggaagggct gcgcggggcc gtcggccggt gggcgggcgc
     8701 tgaccagggc ggggatgagc tcgtcgcaca ggtggtcgtg cagctcggcg gcgctgccct
     8761 tcccgtactc cagcagcggc gccggatcgg cgcgggtggc gatgtaggtc acgcggacca
     8821 gccacagccc cagggacgtc gaggtcacct gggccagggc gggggcggcg cccgtgcgca
     8881 gcgcgtgcag cacctgcgac caggcgggac gcggcaccgg gggcaggcac gcctccaggt
     8941 agtcggccgc ggcgacggcg tccatgggtt gcggctcgat gaccgccgac gccgtcagga
     9001 cgtcgccgag ctcgtcgacc gactcggcga actgctccgt gcggcaggtg aggatgagct
     9061 cgtcgttctc gcacagggaa cggttcagcg cgcgcagcat gtcggtacgg gcgtggtcgg
     9121 gcaactcgtc caggccgtcg atgacgggca gcagctcgcc gcgggccgcc agcgcctcgg
     9181 ggatgccggg gccgagcgcc tccgcgcgca acgcgggata gtccatcgcc aggaacgcgg
     9241 ccagccagtc ctgcagccgc gggtggaccc gctcgtccca gcgggcggcc gagacgagca
     9301 ccgggacgcg ctcgcccggc tcccgggtgc gcagcagttc gaggagcagt tgcacggcca
     9361 gggtcgtctt cccggtgccc ggcccgccca ggatgaccag ccgccggcag ggcagggccc
     9421 ggaacccgca cgccatgtcc ttgatgtgca tcggcaggcc ggggaaggcg acggcgccct
     9481 tggcgatgat ccccggatgg tcgacgagct cgcgccgttc cgtggaccgc cagggcagcg
     9541 gcatcggttc cgggtcgccc agcgagcgca ggaccgtctc ctcgcgccac tgctcggaca
     9601 ccaggccggc gagaatgtcc ttcgcggtgt cgatgtcggc ggaggtggga gcgcgggccg
     9661 gcgcgcggtg ctcgcgccac caggacagga gctggcgcac gccgctgccg agcgtgacca
     9721 cgctggtgac cgtcgccacg aacgtggcga atcccaccac tagcccgttc tgagcggaca
     9781 agcgtcccga gacggcgaga agtccgacgc ccatggcgag aagcaggaga ccccagaaga
     9841 gcaccccgac cgcgcgcgac ttccggtgcg catattgtcc agacataatt ccagtatgtg
     9901 aagaatggcc ccccagaaag ggtcggcaca tgcacgcctg cggcaaaacc ggtccccgtc
     9961 gtccagtgga acgccaagcg tgcgacagcg atccggaaac tcaccggacc gcccgggacg
    10021 ccctcggccc gggaacgacg agatttccgt cggtaatgag catgaaacgc tccaggcccg
    10081 gcaccatgac gtgcacggcg accacgcacc ccggcacggc ccgcaccgtc cgcgcgtaga
    10141 cccgcaaccc ccgcgccgcc agcatcgcgc acaccgcccg tagctgcgcc ccgggcgccg
    10201 ccatcaccgg cccgccgtcg gggaggggca ccacgcgccc ccggcgcagc acctcggtga
    10261 gctcgaaccg cccgcaggcc gccagggcgg ggtaggcggc cggcgccgcc tgatcgccgc
    10321 gtgagccccc tcctagctcc tcgcccaggg tggtctggac gagctcggtg agggcgcgcc
    10381 aggcggcatg ggcggggctc agggaggtgc cggtgccgcg ccggtgcggg cggccgcagg
    10441 cgggggccgt gtacgccagc atgctcggcg ccccgaggtc ggtggtgatg tccagcaggt
    10501 gcaccgggga tccggtcagt tccgccgcca ccgcgtacgc cctggcggcg ggccccggca
    10561 gcgtcccggg gtcgacgagc ctgggccgga acgggcgccc gcacaggaag gcccggacca
    10621 gcagcaggga cagggcgtcg cgctcgatcg tctcgttgag tgcgtgcagc accgcctcgg
    10681 cggcggtgac gccgacggcc gagccgctgt tgcagctgta ccgcatgagg tgggtgtagt
    10741 cgctgtcgtc gccggcccgc tcgcgcagcg gcgcggcccc ggcctccagg taccagggcg
    10801 cggacaggaa cagcggcacg agagcgtcgt ccccgccgtc gagggcgcgg tatcgccggc
    10861 aggccatccg ccgtccgggc atgggggcca gcagcggggc gcaggcgtcc gcgcgcagcg
    10921 gaccggcggc gagcgcggcc ggagcggcgg gctccacggc gtccgggtcg aagcaggcgg
    10981 ggccggtcag gtggtgctcg atggcctcga acagcgcgcc gaggcgggcc tcgtcgaggg
    11041 cgcccttgcc catcccggac gcgaccggcg ccgagcccgt cccgtcgagc agcccgcacc
    11101 accaggcggc cggatcacgg ccgccgccca cgtccacgag ccgcgcccgc aggcccagcg
    11161 cggcgagtgc cgccaccgag cgccggccgg cctcggcgag cggcacctcc cgctccaccg
    11221 ggcagcgcgc gcggcgggct ggtctacccc tcctcatccc cggccgcggc cgtcagctcc
    11281 tccaggcggg cgagctcggc ctcggtgagg tgctgatcgc accggtcgag ggaggcgacg
    11341 gagacgtagt cgacgacgtt tcccatgagg ctcccctttc tcctcgcttc tcacggtagc
    11401 caggccgggc cggaggacca gaaaggaatg aataagccat tcccacgata tttttaacca
    11461 ccgaaaaatg cggcaacaag cggtcaatta cctgccggac aactggacgg cgacggaaag
    11521 cgacgcacac attcgaaagg agaggcctgc ttcggaagag aacggctggc gatgatggaa
    11581 atatcgacgg aagtcggcga gagcagggtg cggcagacca gggccgccgc cgagcggtac
    11641 cgctggagcg gctccgaacg cgacgaggcg tggcgcaggc gcgagcgggg cgaggcgttc
    11701 cccgactccc cggagatgct ggccgcccgc accgcccgcc tcatccagcg caacgggctg
    11761 cccgtcgagg cggcgctgga ggcgaccaga actgacgccc tcgaccagcc ccagatgtac
    11821 gagcgcatcc tcggggtggc caaggacctg cagtcgtgga gcttcctgcc ccgaggcgcg
    11881 cgggccgcgc ggacggtcgc ccggatctgc gtcgccgaga acggccgcga gatcccgatc
    11941 ggcaccggtt tcctggtctc gcccaggctg ctgctcacca accatcacgt gctgcccgac
    12001 gccacggcgg cggcttcggt gatcgtggag ttcgacgccc aggtcaccgt ggacaacact
    12061 cctgaggtct cgcggcggtt cgtcctggct cccgaggtgt tcttcgtggc cgacagcgcc
    12121 ctcgacttcg ccctcgtgct cgtccgcccc gacgccgacg gccgccaggc cggcgacacg
    12181 ttcggctgga accggctcag cgtccaaacc ggcaagctgg tcatcggcga gccggtcaac
    12241 atcatcgggc atcccagcgg ccggctgaag gagatctcca tccgggagaa ccggctggag
    12301 gcgcgcctgg acgagttcct ccactaccag accgacaccg agccggggaa ctccggctcc
    12361 ccggtctaca acgaccagtg ggaggtcacg gccctgcacc acagcggcgt gccgaggacg
    12421 gacgaccagg gacgcatcct gcgccgcgac ggccagccct ggcgcgaggg ggacggtgac
    12481 gacgccgtcg actgggtctc caacgagggc gtgcggatca gcgtcatcct caagcacctg
    12541 gccgccctgc ccctcgacga ggcccggcgc gcctgtctga cggagatggg gccggagtcc
    12601 gggctcgggg ccgtcaccgt cccgccgccc gcccctccga tggacgagcg gccggccgtc
    12661 gagccgggcc cgctcgccac gaccccgcgc acgggcctgc ccgccgcccc cggcgcgttc
    12721 ggcgggtcca ggcatgtggt cttcctgcac ggccgcggcc aggaggaggg cgtccccgag
    12781 gtgttgcgcc ggaactgggc cgccgggctg aacggcgggc tcacccgggc ggggctgccc
    12841 acgatcgagc cggccgacgt ctgcttcccc tactacgcgc accggctgct ccaggccatg
    12901 cggccggtgg aggccctgcc tcacccgccg cacggggccg tcgaggcggt ggcgccggct
    12961 cccggctcca cccggcggct gtacgagcag ctgatcgtcg aggcggcggg gcgggccggc
    13021 ctgccggggg cgggcccggg cagcgccgaa gggctgggcg actccgtgcg gcgcggcctg
    13081 aactggctgg ccgacaccac cgacctcgat cgcctgttca tcgccgccgt cttcgcggac
    13141 gtcgccgcct acctcgacga ccagggggtg cgcgaggccg tcgtggactg cgtgctcggg
    13201 gagatgccgc agaccggccg gctggtgctg gtcagccaca gcctcggcac cgtggtggcc
    13261 atggacctgc tcacccggct ggacccggcg gtggaggtgg agctgctcgt caccgccggc
    13321 agcccgctcg gtctcgacgg cgtgcaccgg cgcctgctca ccggcgggcc ccgccggccc
    13381 ggccgggtga cgcgctggtt caacgcctgg tgccccatcg acccggtcgc cctcggctgc
    13441 ccgctcggcg accgctggac ggacggcccc gaagaggtcg ccgtcgccaa cccggtgggc
    13501 caggcccacg acatcgacga atatctcgcc caccccgagg tggcccagcc gatcggggcc
    13561 gcgctgcacg cggcggctcc ggtggcgggc gccgggtcgg cggcgtacgg aggcgcgacg
    13621 ccatgacgaa tctcaaggta gcgacggtca acggcgagtg gatgaacgac tggttcaccg
    13681 ccgacgccga gacggcggcc ttcgtgccga cgttctccaa ggacggtgag cacggggtca
    13741 ccgcgcaggc cgccggccgc ctggcggggc tgatctcggc gctcgacgcc gacatcgtcg
    13801 cgctggtcga ggcaccgagc cgcccggccg agctgaagct gttcatcgac gagtacctgt
    13861 ccgagaacgg ccgcccggcc tacgacttcg tgctcggcga ctccggcggg agccagaagc
    13921 tcgccctgct gttcaaaccc ggccgggtcg cgctgtccct gacgccctcg tcggaggcgg
    13981 ggccgttcat cgacccgtgg ctggccgacg tggacggtga cgggacgctc aacgagtacg
    14041 ccttcaccag gaacccgctg tgctgcgggg ccgacgtgga cggcggccgg ctgggagtgg
    14101 tggtcgcgca cctgaagtcc aacttcatca accgggggcg ccagctgtgg caggatccgg
    14161 cgcggcgcct ggagttcgtc cgggccgcgc tgcgcaaccg gcggcggatc gccaacgagg
    14221 ccatgcgcat ccgccgggcc atggagcggc gcctggcgac cgagccggag gcggcgatca
    14281 tcgtgctggg cgacctgaac gacggccccg gccaggacta cttcgaggag ttctacctcg
    14341 cgcacaacgt caccgacatc ctggtcggct cgccgtacca gccggagcgg ctgttcggcc
    14401 acgcgcaggc cgacgtcgag gaggagcggc gcttcagcgc cgtgttcgac gacttcgtca
    14461 ccaaggagcc gaaccggcac gtgctgctcg atcacatcct cctgtcgccc gccatgacgc
    14521 acggcggcgc gccgctgacg aaggtgccgg ggtcggggcg cgtcgagcac gacgcgtggg
    14581 cggcccagct cgacggcgac ggctccgccc gggaccggcg cgccaccgac caccgcccgg
    14641 tcagcgtgct gctcactccc gcctgacgtc gtcccggccg cgcaggcgct cctcgacggc
    14701 ctccaccagg ccggcgatca ccccgtgcgg cgaggggctg tagtgcggga ccgcccatcg
    14761 cgtgatcctg gcgtcgatca ccgtggggcg gcccgagccg agcgccgagc ggaaggcgct
    14821 ctcgaactcc tcgatcgtct ccacccggtg cccgtcggcc ccgcaggccc gcgcgtaggc
    14881 ggcgaagtcg gggttgcgga actccaccag gccgctctcc cggtacgccg cgagctggta
    14941 gagcttgatc agcttgaact cctggtcgtc gaagatgatc cagatgaccg ggatgtcgtg
    15001 ctcgacggcg gtcatcagct cgaagccgga cagcgcgtag cagccgtcgc cgcagccgac
    15061 cacgaccgtc cggtccgggt gggcgacctt caccccgatc gcgccgttga cgtgcccggc
    15121 catcggcccg aacgagccgg ccttgcggaa gttctggccc tcctcgacct ccacgtagta
    15181 gccgagccac gccaggtggg cgcccgcgtc ggccaggagg acggcgcccg ccggcaggag
    15241 ccggccgatc gcctgcgcga gctcgcccgg atggatccgg ccggtcaggt gggtgatgtg
    15301 cctgctctcg tagtccttgc cggtcacgtc ggcggccggt acgtcgccga ccttccgctc
    15361 cagcgcgtcg gccagcgcgg cgaccgccgg gcgcgcgtcg gacagcagcg cgtggtcggg
    15421 cgggtacgcc ttgcggaact cgttctcgca gatgttgacg tggatgagca gcttgccgtc
    15481 gaacaggtcc tggcggtagc cgaaggtggc gtgctggttc agcgagttcc cgacgcacag
    15541 gacgacgtcg gcctccctga acgccttcca ggcgctcgcg tgcccgctgt cggagaagac
    15601 tcccagcgcg agcgggtgcg tctccgacac gatgcccttg ccgtcgagcg tggtcagcag
    15661 cgggatctga aaccgttcga ccagccgctt gatctgcggg ccggcgccgc tgcggacggc
    15721 gccgaacccg gcgagcacga cgatccgccg gcgccgcgcg agagcgtccg cgagcaccga
    15781 cgcgatctcc tcgacgcggg ccgggtcggg cgggacgggc gcgacgtcga gccggacggg
    15841 ccgcctgttc cggacctcga cgccgcgctc ggtcaggtcc agggggacgt ggatgtgcac
    15901 ggggcccggc cgcccctcga aggcgcggtt gacggcctct tcgagcacgt cgaaggtgtc
    15961 ctcggcggat tccagcagga aggacttctt ggtcgtggcg gcgaacatgg cccgggagtc
    16021 gggtgtcccg ccgaggcccg aggtctcgtt cagcgagccc cagccctgcc acttcctggg
    16081 cgcgtagccc gagaccgcca ggaccgggta ggagtcggac atcgccatgg ccagccccga
    16141 gaacaggttg aacgcgccgg gcccggccgt ggcgaagcag aagcccagct tcccgctgaa
    16201 catcgcgtat ccgcacgcca tgaacgacgc cgcctgctcg tggcgggtga tgatcggccg
    16261 gatccgccgc gagtgcttca gcgccagcat caggcccgcg gcgttctccc ctgctccccc
    16321 gaaggcggcc tcgacgccga cgtcctccag cccggcgacg atggcctcgt agaccttcac
    16381 tgacgtgctc cgtccccgtg ccagcgtgcg tcatgccgcc gatgggcgtc ggtcgtcccg
    16441 tcggcgaaga aacgctcgta gtactcggtc tcgacgtgat gggtctgcag ccagatgccg
    16501 ggcacgtgga tggcgtcggc gtgggcgggg aagcggccgt gcgtctcgtg gatgtagacg
    16561 cagacgtccc gcgcgcagtc gatcacctcc tgctcgtacg cgctcgcctc ggccaggtaa
    16621 cgccgcccgt agtcgccctt gtagatgcgg gcgaacgtcg cctcgtcggt gtagatgccg
    16681 ccggggccga acttggcccg tacgacgtgg tccacggccg cctccatcga cgggaagttg
    16741 ggcgggcagg cggccctgat gagctgctcc ccgttcaccc gcaggcccac ggggtgggag
    16801 cgcagcgtgg cgtacctggg cagcggcacg tgccagcgca ggacgtcggc gaggcggaag
    16861 cgcggcgtga cgaagtcgaa gccgagcatc cggccgtagg cgcgggagaa cttcgggtcg
    16921 cccagcatga tctgcggatg gatggtgccg tggatccagg cgccgagccc catcgcgtcg
    16981 gcggtcagca tcaggttctg catgagcagg tccgcctcga tctggacgcg catcgtgccc
    17041 atggcgccga gcggcacctt gacgtccggg ttgaggaacc cgttcttgac ccatttggcg
    17101 acgcccgccg gccggtagag gttgcggtcg tcgacgaacg tcggcctggc cccctccggc
    17161 tgggtgagca ggaacatcag gcagttgatg tactggtggg agaggtccac cacgggcagg
    17221 aagatcgtgc tgccggggag gttcgacagg aaccggttcg cgtcgaggta ggcggggaag
    17281 tcccgccgcc cctcggccac gtcgagccgg tggctgagca cccgcacctt ggcctggcgg
    17341 gcccgctcga tcagcgcttc ggcggtgaag ggcagggcgg cggcgggcgg gagcttcctc
    17401 aggtagtacg tgccggtgtc gttgatcatg aagaagtggg tgccctgggc gttgtcgggg
    17461 ctgcccgccg tccggccggc catcgtgagg ttgggcttgg ccatgatcgg gtcgccgtcc
    17521 cgcggatcct cgaacggccg gtccggcatg gtcaggccgg agcagccggt gagcgcgatg
    17581 agcagcgcct cctccagctc cgtcagcggc atcggcggat gcggcgaccg gtagctcatc
    17641 gagccggccg gcacggacgc gccgcggctg acgcggtgcg tccggcgttt ccagatggtc
    17701 tccagcagcg gccgggccag gagcgcttcc agcccttcct gcctggtggc cggcttgacg
    17761 tccatgatcg gctcgctttc agtcgggcgt ggtgccggtg ttcgcctccg gcctggccgg
    17821 gcgccacggc gcgaaggcgc tggtggtcct gggcagcacc gccgccagcc cggggcagtg
    17881 ccgcaggatg acgctcgtca tgccgttgcg ggcgacccag tccatcccca gcggggtgta
    17941 gatctcggga cggaagtcga cggtgaggaa gcggtcgctc tgcaaccggc ggctggccat
    18001 gaggatgaag atgcggaacg ccgtgtcgct gaagccgaag cgctcgggcg ggttctccgc
    18061 gaagagcccg accatcgtgt cgatgtcgtc gaccgagcgg tagacgtccc gcagccgcgc
    18121 caggcagtcg gggttggtgg tgaggtcctc gaagcggcgc aggcggggcc ggtgcaggcc
    18181 ggcgcggaag tcgttgtagc gcggcacggc gcggcggcgc gtgcgcacca ggtcgaccac
    18241 ggacaggtcg atgatctcgc cctcccgctc gaacgcctgc agcgcgcgcg ggaagttgcg
    18301 cagcgtgatc gctccgggat gggcgatgcc gagcgagtac agcgcgttgg ccaggccggt
    18361 gcggcgcatg accggctcgg tggcggcgcc ctggaggtcg tggaagccga ggctctccag
    18421 ccgccgcccg gtccggtggt cggccagctc gtagtcgtcc gggatcagcg ggtgcatgcg
    18481 gtagacggtg acgaagtcct cggtgagcga gtagggcgtg ccgtggtggt cgggcaacgt
    18541 ccccgggatg ccggtgagcg cgtgcgcgtc ggccagccac agcccgagat gggtcagcca
    18601 gctcttcggc ggcccctgcc agttggcctt caggccgatg tcgatcagct cggtggcgag
    18661 gatggcgggg gtccactcca cggtgtggat cttcgcgatg agggcggaga ccacgagcct
    18721 ggccgtgtgg tacacggact cctcgtccat gccgggatac tcctcgcgca gggcgcggca
    18781 cacggcgttg tgctcgcggg cgaagagcgt gtgcatgacg ctgagcccga gccaccagtt
    18841 gttgcggaac ccggtgatcg ggatgccgtc gggccccggc accaggtgcc cgttctccag
    18901 gcgcagcgac gcgtcgccgt ccggctcgcg cagggacttc gcgacgctct cgtccccgcc
    18961 gtagacctcc gagccgtccc accagtggga ggccgcgttg gccgacagga tgggcggccc
    19021 cgtcccgccg gccgggcgca ggtcctcgtt gtcggcgaag cgcatcacgc gctccggcgc
    19081 gcctcccggg gtgttggtcc acgtcatgcc gtacgggagc ggcacctcga cgctgccggc
    19141 cccggccggg cagcgcttgt ggtccaccca gtcgtgcacc tggaactgga tccaggcggc
    19201 ggcgatcacg ttgagcgacc gcgccgggat gaagctgtcg cggtggagca gctccctgct
    19261 gacgacgacc gggttcggct cgtcgaacag gtccggccgg tggacgggcc gcaggttgcg
    19321 gccgaaggtc gcgccgagcg cgcccatggc ggggtcggac aggtcgttgt aggtgccgtc
    19381 gtaggtgcgc ctgacgagca ggctctcgtc gagggccggg ggcacgggat ggggccgggg
    19441 cggcgcctgc cgcacctcgg tgtcgaacag gttctcgcgg cgcagcacct gccggatggt
    19501 cgcgacgttg agcaggccga tccaggtcgg cagccggtgc caggggacga accggttgag
    19561 ggcgccgaac gcgccgcgca gcagggcgcc cgcgacgacg ttgcgtctcg gcgtcggcgt
    19621 gacgaagcgg cgcccccggc gatgggcgct gctcgccttg taggcggcct tgcgggcgcg
    19681 gttcaggttg ccgaggggcc ggaaggcgtc ggtggtgttc cacgggtcga aggcgagctg
    19741 gtcgatgcgg gccgcggcgg cgcgggcggc cgcggtgccg aggtcctggc gcgggatcgt
    19801 cagcgtggcc acggggacga cgggcacgtc ggcgtcgggc cagtcggcgg cgccgttctc
    19861 gatgggcgtg agccgggcgt cctcgtaacg ctgcacgcac agctcgaaga cgatgtcctg
    19921 cctggccagc cgggccgcca gctcgtgcga gaggtggtcg gcgtcccagg gcggcggagc
    19981 gggcaccgcc ggcgacaccg cggccggcct gagacggtag cggaccgggc cggcctcgcc
    20041 ccagaggatg gcgctgcggc tccagtacgt ctccagggcg aggctgcgta cctcgcggcg
    20101 ggctccggca agcacgttgc gccgcatgcg ggcggcggtg gcccagccca gggcccacgg
    20161 cagcctgacg tacagcgcca gggcccggcg cacggtggtg tccgcgccgg ccatgacccg
    20221 cgcgaacacc acgaactcgc gggcgttcgc ggcgtgggag accggatggt tggtcatgag
    20281 gaggtcgtgc gcctccccgt ccccggcctg gatccgcagg gccgcgcccc tcaggtccgg
    20341 ggcggggtcg ggccggcggg caccgctcgc gttcgacagc cggatgatga ccgggtattc
    20401 ggcgccgggc tgcgcgaacc cggtgcgcag ctcctgaggc agggagtcat ggaatctcag
    20461 cgtggcgttc tcgaccccca ggatcgcctt cgcgtggaag gtccggtcga tcccggacgc
    20521 gccgccgcgc tccttgatct tcaactggac gcgcatgagg tcgtcggcga gccgctggag
    20581 gatcacccgc tccgcctcgg gcgaaccccc gacgtagcgc tcgtaccgct cggacgtggg
    20641 gcgttcgcgc gccgccggcc gctcgcggac gacacgctcc tgctgcttgg ccatgtgact
    20701 tcccccgaga gtgcggccac cgcgctgggc gggatctccg tgcgctattc ccccgctcgt
    20761 cggggcgacg cgccccttcc cccagcgctg cccattcttg gggaaatggc tatcttccct
    20821 gatcattcgc ggcatcgcgg cccggcggcc ttctccacgc cacgcgggcg gcgggcccgg
    20881 ccggaaggcc gggcccccac caggtcacgc gctgatcagc tcggcgaccg tgaggtcgcg
    20941 gaagaccgtg atcggcacgt cctccgacgg acgctggaag agcgcccccg acgaccggtg
    21001 cggcaggtcc accgtgcgta cgtggcggaa gccgcggtca cggtagtagc cctgcagccg
    21061 cgggttggcc ttggcgcagt cgaggcgcag ccagggcagg cccgccgagt aggccgacgc
    21121 gcaggcccag tcgagcagcg cgtccccgag gccggagccc gaccaggggc gggcgacggc
    21181 cagcttgtgg atgtagagcg ccgcccccgg gtcgtcggcg ggggtccaga actcggggtc
    21241 cgcgtggtcg tccagggcga tggtggccac cggcggggcc gcctcgtccg ggtcgaggta
    21301 cctgagctcg tcgtccagca ggaacagcac ccgctcctcg atgagcggct cgatccgctc
    21361 ggggccgaag ccgccgcggg gccattgccg cactccctgc gcgtgcagcc actcggcggt
    21421 gtcggcgagc agcgtgagga cgccgggaag gtccgcgggt tccgctctgc ggagggagag
    21481 cgggtgaagc agggtgtttg tgtgcatagt agtacccttc gttgcgttgg gtgttcgcgc
    21541 ctgcgcgcag cgtgatgacg caatgtcgcg taggggcgaa atggggcctc aacccgatat
    21601 atatggataa atggcgattt aggggagtat gcacgactcc cctaggccag cgaggcggct
    21661 atttctcgct gcgcccggcc ggcgggatca ccccttcacc cacgagctcg tcagcggcga
    21721 tcgagctcgt atctgatcag atgtttgtcg gctggcaaaa ccgacacggc gacacgcaca
    21781 ggcatgtctg ccccgtcgta ccccactcgc acgtacacca tgactggcgt accgagctcg
    21841 agttggaggc gttcggcctc ctcctggttg ggcatgcgcg cccagatgtc gtccacgacg
    21901 cggacctgcg catggcccag ctcttccagc acccggttcg cccctcgcgc gatgtctccg
    21961 ggcctggcga tctcggagtc ggcaaccaga tcgcggggga agtaggaatc gttggtgttg
    22021 tacggctgtc cgtccacgaa acgcagacgg cgtctcacca ccgccaattc cccgtcggcc
    22081 agctccagcc tgctggcgat ctcctcgacg ggagacaccg tcagcacctc gatgtactgg
    22141 ctgggggccc ggccttcctg cccgacggcg taggcgaacg cctcgcgcag ttccccgctg
    22201 ggttgcggct ccagctcccg ctgcgggtag atcagcagcg gtctgcggtc tctgaccacg
    22261 gtgccgcgcc gcggcgtgcg cgtgaccaga ccctcattga cgagttcgcc gagggccagc
    22321 cgcaccgtgt tcctgctcac cccatggtct tccatgagct gcgcctcggt cggcagctgc
    22381 gccccggggc cgaggacacc cgagtagatg gctcgtcgca actccgaagc cacctgctga
    22441 tacagcaccg accttgccac tttcacccct tttgttccaa caatttagac gatctggttc
    22501 tagcaggcca caaccccttg accgaaccgc ctccaccggc ccatcatcca ttcgttggta
    22561 caaatccatc taaaggccgg tgagggggtg aaggccagtg ttgccggtcc gcacgggtac
    22621 gccatacctg ccctggcatg acccccgcga agcaacacgt ttactgcgtt acgcgttgac
    22681 tcgccagggg ttcacccaca cctgccggag cgacggcgtg cccgagccat cgatgcccat
    22741 cgagctgacc gtgcggtgcg acgacggatc ctttgtcggg aacaaggagg gtggcgcccc
    22801 cgtcacgcat cgctttgatg acccggtcgg tgcagctcat cgcatcgccg cacgtcgccg
    22861 gcgaccggag ccttcgcgct cccccatcga ctccgtgtgc gagtcaacgg cctaggactc
    22921 catccctcgc cggagtcctg gcgccgtcgc acgcggggca ggaagcgcgt cctggcgggt
    22981 cccccacgcc cgccaggacg cgctctcctc cgaggaccgg cctcgcgcct ccatcgctcc
    23041 cgatgggggc tttttctttg cctgccggcg gatcccgcga cctgccggtc acgtccgccc
    23101 tcgtctgcgt accgctcacg tctgccgcca agtccgcgcc gtccatcccg acaacgcctt
    23161 ctgccacaca tcatcgaccc tcggaggccg gcctgggggc tgcttcgtga tggtgggact
    23221 ggtgggattt tccggtacca atccaattcc gggcccaagg tcaacgaacg ggagaatttt
    23281 caccggaccg gatggcgatg cggctttccg gcgcccaatc cagaaccgtc agctcctcgt
    23341 ccacctgcgt gaacgtgccg cgcacccgct cccccgcctc cggctgacgc tccgcccgcc
    23401 agtttccata caccagagcc cccggtacgg ccgtcaaacg aaccattacc actaggtatg
    23461 gatcgcgatg ccccggaacg aacggttgac ggctgacgat ccagctctca accgtcccct
    23521 cggggaccgt ctcgcgccag tgccagccct cttggcggca ggcggcacag aacgcccgcg
    23581 gagggaagcg aagagtgccg caggcgtcac attcctgtac cgcgaactcg tgccgggcga
    23641 gccgatccca ccaggcacgg gagtcacggt ccggctcggg acggtagccg ggcatcacgc
    23701 cctcctcagg atcagggcgg aggtggcggg caggacgtag ccgggctgcg ccgtggacag
    23761 cgccacctcg gcgcccggca cctggcggtc cccggcctcg cccctgagct gggagaccgc
    23821 ctccgcgatg tggttgacgc cgtggacgta gccctccgac aggaagccgc cgtgcgtgtt
    23881 gacgggcagc gcgccgtcca gggcggtggc gcccgaggcc acgtacgggc cgccctcacc
    23941 cttcgggcag aacccgtagt cctccagctg cacgatcacc gagtaggtga agcagtcgta
    24001 cagctcggcc acgtcgatgt cggccggccc gaccccggcc tgcgcgtaca ggcggggcgc
    24061 cagggcggcg gcggccgtca ccgtggggtc gtcgcacgac aggtgggagg tgccgccgcc
    24121 ccaggccgcg gccgagacga gcaccgggtg gcggcgcagc gagcgggccc gctcggccgt
    24181 ggtgacgacg acggcgcagg ccccgtcggt ctccaggcag cagtccagga ggcggaaggg
    24241 ctcggcgatc cagcggctgg ccaggtagtc gtcgagggtg atgggggtgc gcatgagggc
    24301 gcgcgggttc ttggcggcgt tggcgcgctg ggtgacggcc agggcgccga agtgctcggc
    24361 cgtggtgccg tagcggagca tgtgggcgcg ggcgtacatg gcgaactgct ggggcggcgc
    24421 cacgtacccg tacggggcct ggtactgcac ctcggggctc gcgggcaggc cgcggccggt
    24481 gccgcccatg cggaactccg agcgcgcgtt gatggcgcgg tagcagacga cgacctcggc
    24541 caggcccgcc gcgacggcga gcgcggcctg gccgacgacg gcgtgggaga cgctgccgcc
    24601 gccgaactgg tcgaggtgcc aggacagatc gctcaggccc agggcggggc cgacgagggt
    24661 gggcggggcc gagtcgccga cgcggtgggt ggccaggccg tccacctcgt cgggggtcag
    24721 gccggcgtcc tccagcgcgg cgagcacggc gcggcaggcc agggtcaggg tgctgacgcc
    24781 ggagtccttg gagaagggcg tgtagccgac gccggcgatg gcggtccggt cggtgaattc
    24841 aagcaagcgc ttgggcacat gcgtcacggt aggcaggctc tttccggcct gtcaacgcag
    24901 gtccgggagt gcgacttgac accttttccg cgttccccct accgtccaag caagcgcttg
    24961 gtaagatggg ctcattcggc ggatcgagga ggcggaccat gagcacacac gctgcccggc
    25021 tgatcgcgcc ggacggctgc cgcagccttc cgacgcccca tcagcgcagc aggattcgca
    25081 acggagccac catgccgacg gggcactcgc agcacagcca gaacggccag ctcgacagcc
    25141 gccgtttccg gcaggtgctc ggccggttcg cgaccggcgt ggtggcgatc acggccgtcg
    25201 accccatgga cgggcagccg tgcggcctgg ccgccaactc cttcacctcc gtctcgctcg
    25261 acccgcccct catcgcgttc tgcgtggcct acaccagcac gagctggccc aggctgcgcg
    25321 gcgccaaggc catgaccgtg aacgtgctgg ccgagcacca gcaggccgtg tgcgcgcaac
    25381 tggcgaccaa gggcggcgac aagttcgccg gcctcgcctg gacggtctcc cccggcggca
    25441 accccgtgct cgaaggcgcg ctggcctggc tcgactgcgc cgtcgaggcc gagcacccgg
    25501 cgggcgacca cctgatcgtg gtggcccggg tgctgcagct cgacacgtac gccgaaggcg
    25561 ggccgctggt gttcttccgc ggcggctacg gaggctttgt tgagccttcg tgaggaggcg
    25621 cgggcctggc tggaggagag tctgagcggc gagttcgccg gggccagggg gctgggcggg
    25681 ccggggcgcg agcacgaggc gtacgagctg cgccgggcgt gggagcgcca cctcggcgcg
    25741 cacggctgga cctgcctggg ctggccgcgc cgctacggcg gccgcgccgc ctccatcggc
    25801 gaccaggtcg ccttccacga ggagtacgcc agggccggcg cccccgcccg cctcggcctc
    25861 atcggcgaag gactcatcgg cccgaccatc ctcgacttcg gcaccgccga gcagaaggac
    25921 cgcttcctgc cgcccatcca gcgtggcgac gagctgtggt gccagggcta ctccgagccg
    25981 gaggccggct ccgacctggc cggcgtccgc accagggccc ggctcgaagg cggcgaatgg
    26041 gtgatcaccg gccagaaggt gtggacgtcg ctggcgcagt gggccgactg gtgcttcgcc
    26101 ctgtgccgca ccgaggaggg ctcgcagcgg caccgcggcc tgtcgtacct gctcgtgccc
    26161 atgcggcagc cgggcgtcga ggtccgcccg atcgtgcagc tcaccgggac ctccgagttc
    26221 aacgaggtgt tcttcgacgg cgcccgcacg gcggccggca acatcctcgg cgcgcccggc
    26281 gacgggtggc gggtcgccat ggccacgctc gggtacgagc gcggcgtgtc cacgctcggg
    26341 cagcagatcg gattcaggcg ggagctggcc gaggtgatcg cggccgcgcg gcgcacgggc
    26401 gcgatcgacg acccggtgct gcgcgaccgg ctcgtacggt cgtggctgga actggagatc
    26461 atgcggctga acgcgctgcg cgtgctgcgc cccgaccccg gccccgaggc gtcgatcacc
    26521 aagctgtact ggtcggagtg gcaccgcagg ctgggcgagc tggcgcaggc cgtgcagggc
    26581 cgggccgggc tggtcgcggg cgacgacggc acgctcggcg agctgcagcg gctctacctg
    26641 ttcagccggg ccgacaccat ctacgccggc tccagcgaga tccagcgcac cgtcatcgcc
    26701 gaacgcaccc tcggtctccc ccgctgatcg ggcccactga acggagccgc cgatgtcacc
    26761 gccgtacccg aaggcccacg ggctgctcga cggaaaggtc acgctggtca cggccgccgc
    26821 cggggcgggc atcggctacg ccacggccag gcggtgcgcc gaggagggcg ccacggtcgt
    26881 gctctccgac cggcacgagc gccgcctggc cgccgccgcg gagtcgctgg ccgagctcac
    26941 cggcgtcaag ccgctcgccg tcccgtgcga cgtgaccgcg caggcgcagg tggccgagct
    27001 gttcgaggcg gtcgtgcggg cgcacggccg gctggacgtg ctggtcaaca acgccggcct
    27061 cggcggtacg gcggagctgg ccggcatgac ggacgagcag tggcacgccg tcgtcgacgt
    27121 caccctgacc ggcaccatgc gctgcaccag ggcggcgctg gggcacatga tcccgcaggg
    27181 cggcggcgcc atcgtcaaca acgcctccgt ggtcggctgg cgggcccagc ggggccaggc
    27241 gcactacgcg gcggccaagg ccggcgtgat ggcgctgacc aggtgcgtgg cgatggaggc
    27301 ggccgagcac gggatccggg tgaacgcggt ggcgccgtcg ctggccgtgc atccgttcct
    27361 ggcgaaggtg accagcgagg agctgctggc ggagctggcg gccaaggagg cgttcgggcg
    27421 gtcggcggag ccgtgggagg tggcgaacgt gatcgtcttc ctggccagcg actacgcgtc
    27481 gtacatgacc ggggaagtgg tgtcggtttc ctcgcagcac ccctgacgat atcttgcgag
    27541 acaagatatc gtgggcgcat gaatatgacg gagcccatgg tcctggcgct gaccgcgctg
    27601 gtggacgagc cgcggcacgg ctacgggatc gtccaggagg tcgatcggct gtccgaaggg
    27661 cgcgtccagc tcaagatcgg cacgctctac ggggtgctcg accggctctc cggcgccggg
    27721 ctggtcgcgc tcgaccgcga ggaggcgcag caggggcggc tgcgg
//
