LOCUS       NZ_CP017717            21002 bp    DNA     circular CON 03-MAR-2024
DEFINITION  [Actinomadura] parvosata subsp. kistnae strain ATCC 55076
            chromosome, complete genome.
ACCESSION   NZ_CP017717
VERSION     NZ_CP017717.1
KEYWORDS    RefSeq.
SOURCE      [Actinomadura] parvosata subsp. kistnae
  ORGANISM  [Actinomadura] parvosata subsp. kistnae
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Streptosporangiaceae; Nonomuraea.
REFERENCE   1  (bases 1 to 13047416)
  AUTHORS   Nazari,B., Forneris,C.C., Gibson,M.I., Moon,K., Schramma,K.R. and
            Setedsayamdost,M.R.
  TITLE     Nonomuraea sp. ATCC 55076 harbors the largest actinomycete
            chromosome to date and the kistamicin biosynthetic gene cluster
  JOURNAL   Medchemcomm (2017) In press
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 13047416)
  AUTHORS   Nazari,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2016) Chemistry, Princeton University, 20
            Washington Road, Princeton, NJ 08544, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 18-JUN-2015
            Assembly Method                   :: Celera Assembler v. Jun 2015
            Assembly Name                     :: SmrtPipe 1.87.139483
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 110.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/03/2024 13:15:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 12,000
            CDSs (total)                      :: 11,919
            Genes (coding)                    :: 11,783
            CDSs (with protein)               :: 11,783
            Genes (RNA)                       :: 81
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 136
            CDSs (without protein)            :: 136
            Pseudo Genes (ambiguous residues) :: 0 of 136
            Pseudo Genes (frameshifted)       :: 36 of 136
            Pseudo Genes (incomplete)         :: 98 of 136
            Pseudo Genes (internal stop)      :: 10 of 136
            Pseudo Genes (multiple problems)  :: 6 of 136
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:57:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6533251
            Orig. end                         :: 6554253
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP017717.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21002
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="25"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21002
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21002
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11002](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11002
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(944..3871)
                     /locus_tag="BKM31_RS29505"
                     /old_locus_tag="BKM31_29245"
     CDS             complement(944..3871)
                     /EC_number="2.7.7.42"
                     /EC_number="2.7.7.89"
                     /GO_function="GO:0008882 - [glutamate-ammonia-ligase]
                     adenylyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541544.1"
                     /locus_tag="BKM31_RS29505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_29245"
                     /product="bifunctional [glutamine synthetase]
                     adenylyltransferase/[glutamine
                     synthetase]-adenylyl-L-tyrosine phosphorylase"
                     /protein_id="WP_080041239.1"
                     /transl_table=11
                     /translation="MPRIESTAARLAKLGFADAVRAAQLVRQSEADLDDILESLVEVAD
                     PDQALVSLIRLIEREPAVLEAVRSDEVLRGRLLAVLGVSAALGEHLVRHPGQVARLAEQ
                     RLGEARAELLRAVGAEPGESEPRAAEGGTGALTALRVAYRGRLAHLAARDLTGQATLGE
                     VTAELSDLAGAALEAALAVARTEVEAGEVRFAVIGMGKCGARELNYISDVDVIFVAEPR
                     EGADEAKALRAATRLAQAMMRACSATTPEGSLWEVDAGLRPEGRSGPLVRTLASHLAYY
                     RRWAKTWEFQALLKARPVAGDLELGGAYVEAVNEMVWSAATREHFVEDVQAMRRRVEAH
                     VRAEGERQLKLGPGGLRDIEFAVQLLQLVHGRLDPLLRRRATLPALAALSRGGYVGRDD
                     SRGLAEAYTFLRQVEHLLQLHRLRRTHVVPTGDDDLRRLGRALGMQADPVGEFTARWRR
                     HAMEARRLHEKLFYRPLLQAVARLPESEARLSTAAAAARLEALGYVDPRGALRHIANLS
                     TGVSRRAAIQRTLLPVMLGWFADTPDPDAALLGFRQVSDKLGSTPWYLRLLRDETAVAA
                     RMARVLGTSRYATGLLMHAPDAVAMLGSDDELAVRPPESLLGEASAAVSRYAGDPEGAV
                     TAVRALRRKELFRTAVADISGLIDIETVGTALSRLNDVTLQAALDAALSKVPPVTSFAI
                     IAMGRLGGMECSYASDADVMFVHSPRPGADEREAGDAAFAVANELRRLLSLPAPDPPLL
                     IDPDLRPEGRQGPLVRTLASYRAYYSRWSAPWEAQALLRARFSAGDAELGAAFTAMIDE
                     LRYPQSGLRDDAIREIRRLKARMEAERLPRGADPALHTKLGPGGLSDVEWVAQLLQLCH
                     AGERPSLRTTRTLEALRAAVGEGLLDPDDEAVLAESWRFASRVRDAIMLMKGRPGDSVP
                     RDGGERRMLAQTLGYPPDGSEDFLDDYRRVTRRARKVMDRVFYGA"
     misc_feature    3895..3911
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.54"
                     /tool="antismash"
     misc_feature    3930..3939
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.11"
                     /tool="antismash"
     gene            3950..4483
                     /locus_tag="BKM31_RS29510"
                     /old_locus_tag="BKM31_29250"
     CDS             3950..4483
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541543.1"
                     /locus_tag="BKM31_RS29510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_29250"
                     /product="HXXEE domain-containing protein"
                     /protein_id="WP_186404781.1"
                     /transl_table=11
                     /translation="MAAGRVPAGVAWGLLAAWAVHDAEELATMARWTRAARPRLEERFP
                     RVPWERIEVSQAHASVAIGLMGGVMATASALGARTGGRSAMFQAALAGFGVHGVVHLAQ
                     AALFRGYTPGVVTAPVVVIPYAVWAWRRLRRAGVPATGPGAAVAAFPLVLAGVHVGAHA
                     LTSGRKKVRRDGRS"
     gene            complement(4538..5221)
                     /locus_tag="BKM31_RS29515"
                     /old_locus_tag="BKM31_29255"
     CDS             complement(4538..5221)
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1249: carbamoyl phosphate synthase small subunit"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541542.1"
                     /locus_tag="BKM31_RS29515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_29255"
                     /product="type 1 glutamine amidotransferase"
                     /protein_id="WP_080041241.1"
                     /transl_table=11
                     /translation="MRITVIEHEAEAGLGYLAQWLGVACEVVRPYLGEEVPERAADGLV
                     VLGGAAAAWEDERSPWQPATRDLLRRAVDDATPTLAICLGAQLLTLACGGTVERGGNGL
                     EVGAREVVALPAAATDPLLSGITTAVAIQYHQDAMTRLPDGAVPLMTGAQYPNQAYRLG
                     EAAWAVQFHPEATPEIFASWTADSGLDTAEELNAGVKAAESALVATWRPVARAFADIVR
                     NGRPA"
     misc_feature    complement(5201..5215)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     misc_feature    complement(5207..5222)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.62"
                     /tool="antismash"
     misc_feature    complement(5215..5229)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.04"
                     /tool="antismash"
     misc_feature    complement(5228..5242)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.78"
                     /tool="antismash"
     gene            5243..6091
                     /locus_tag="BKM31_RS29520"
                     /old_locus_tag="BKM31_29260"
     CDS             5243..6091
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (19-268). E-value:
                     8.5e-18. Score: 56.8. Matches aSDomain:
                     nrpspksdomains_BKM31_RS29520_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541541.1"
                     /locus_tag="BKM31_RS29520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_29260"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_222107860.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.6e-14, bitscore:
                     53.8, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 5.3e-13, bitscore: 48.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIDEVGGLRIATFGTGPRTIIAVHGITASLMAWAGAGRRLPEGW
                     SLVAMDLRGRGHSAGLPGPYGLPRHAEDVLRVADHVGAGPDAVLTGHSMGAYVAALAGA
                     QREFARVVLVDGGIPLAPIPEGTDPDAALEAALGPALARLRQTFPSAEAYVDFFKAHPA
                     FAGRWNADVEAYVRYDLTGPEGALRSRAAGEAVLADGRWLHLEREAIGAALTAIKAPLF
                     LLRAPRGLLDQETGMLPDDLVRPWKERLPGLRDEVVPDCNHYTILFDERCVATVVDRLT
                     A"
     aSDomain        5300..6046
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BKM31_RS29520_Abhydrolase_1.1"
                     /evalue="8.50E-18"
                     /label="BKM31_RS29520_Abhydrolase_1.1"
                     /locus_tag="BKM31_RS29520"
                     /protein_end="268"
                     /protein_start="19"
                     /score="56.8"
                     /tool="antismash"
                     /translation="TIIAVHGITASLMAWAGAGRRLPEGWSLVAMDLRGRGHSAGLPGP
                     YGLPRHAEDVLRVADHVGAGPDAVLTGHSMGAYVAALAGAQREFARVVLVDGGIPLAPI
                     PEGTDPDAALEAALGPALARLRQTFPSAEAYVDFFKAHPAFAGRWNADVEAYVRYDLTG
                     PEGALRSRAAGEAVLADGRWLHLEREAIGAALTAIKAPLFLLRAPRGLLDQETGMLPDD
                     LVRPWKERLPGLRDEVVPDCNHYTILF"
     CDS_motif       5495..5548
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BKM31_RS29520_0001"
                     /evalue="6.50E-04"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="BKM31_RS29520"
                     /protein_end="102"
                     /protein_start="84"
                     /score="11.6"
                     /tool="antismash"
                     /translation="PDAVLTGHSMGAYVAALA"
     gene            complement(6175..6888)
                     /locus_tag="BKM31_RS29525"
                     /old_locus_tag="BKM31_29265"
     CDS             complement(6175..6888)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541540.1"
                     /locus_tag="BKM31_RS29525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_29265"
                     /product="hypothetical protein"
                     /protein_id="WP_080041243.1"
                     /transl_table=11
                     /translation="MTTAALQTVLTVPQRFRGPVGVANGGWIAGTMAEALNGGRSAVEV
                     TLHAPTPLETELRLEHVANTVSLSHGDKLLVEAIPVAEELEGPGFVPFNDAARAEAGFA
                     GLKAHPFAECFACGLREPGDGLRIFPGPVEGSDLVAAGWRVPFTVTGEDGVPASIVGAV
                     LDCITGWAHFGPGESALLGRLAVQIHRPVLPGGRYSVVARPTGRDGRKMFGQSAIYEVD
                     GTLVAAARATWIAPR"
     misc_feature    6927..6940
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.35"
                     /tool="antismash"
     misc_feature    complement(6930..6944)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.57"
                     /tool="antismash"
     misc_feature    7142..7155
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.42"
                     /tool="antismash"
     misc_feature    7198..7211
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 17.68"
                     /tool="antismash"
     misc_feature    7271..7287
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.88"
                     /tool="antismash"
     gene            7329..7937
                     /locus_tag="BKM31_RS29530"
                     /old_locus_tag="BKM31_29270"
     CDS             7329..7937
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889399.1"
                     /locus_tag="BKM31_RS29530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_29270"
                     /product="AAA family ATPase"
                     /protein_id="WP_230465422.1"
                     /transl_table=11
                     /translation="MEGARLRYPPGALVILTGLPGAGKTTLLRRLYGMHGAESLPVTSG
                     AVAVIDSAQSKRHWQGRLAWAPYPVRRAVVFVTHVTRIRQALTQGHAVVAHNRGCGPYV
                     LRGFAWLARRHGADFHLLLLDAPPDEALAGQRARGRVVAARTFARHQRRWDSLLARVKG
                     GDPAPAAGARIMDRAEAGLLEAIVFDSISGTGPRRPSRT"
     gene            complement(7939..9300)
                     /locus_tag="BKM31_RS29535"
                     /old_locus_tag="BKM31_29275"
     CDS             complement(7939..9300)
                     /EC_number="6.3.1.-"
                     /GO_function="GO:0004356 - glutamine synthetase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006542 - glutamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013151975.1"
                     /locus_tag="BKM31_RS29535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_29275"
                     /product="glutamine synthetase family protein"
                     /protein_id="WP_080041245.1"
                     /transl_table=11
                     /translation="MDRQQEFVLRTLEERDIRFIRLWFTDVLGFLKSVAIAPAELEGAF
                     AEGIGFDGSAIEGFARVYESDMLAKPDPATFQILPWRSETPGAARIFCDILMPDGTPSH
                     ADPRWVLKRTLAKCADMGFTFYTHPEIEFFLLKNRPEPGQRPEPIDSGGYFDHTPHSSG
                     HDFRRQAIMMLESMGISVEFSHHEGAPGQQEIDLRYADALTTADNIMTFRLVMKEVALE
                     QGIWASFMPKPFTEHPGSGMHTHMSLFEGDRNAFYEAGTDYRLSKIGRSFIAGLLRHAA
                     EITAVTNQWVNSYKRLWGGAEAIAGLGGEAPSYVCWGHNNRSALVRVPMYKPHKGGSTR
                     IEFRSLDSACNPYLAFALILAAGLKGIEESYDLPPAAEDNVWTLTSAERRALGIQPLPG
                     SLNDAIEVMERSELVAETLGEHVFDFFLRNKRSEWREYRRHVTEFELGRYLPVL"
     misc_feature    9355..9372
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.1"
                     /tool="antismash"
     gene            9456..10001
                     /locus_tag="BKM31_RS29540"
                     /old_locus_tag="BKM31_29280"
     CDS             9456..10001
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541536.1"
                     /locus_tag="BKM31_RS29540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_29280"
                     /product="EF-hand domain-containing protein"
                     /protein_id="WP_080047056.1"
                     /transl_table=11
                     /translation="MAIDLLNHKLDRAFDHIDASGNGVVEREDLLGLGARILVGFGESP
                     TSVTGASLVESFDRIWSTLSETLERDGDSGIARPDFRRGMTAAFVEGDRYDAVFRPATV
                     AVAELCDGDDDGQIGPGEFRTMLCAFGVAYDDVDEAFDRLDRAGRGALTVEELVVAAAD
                     YYRGDDPNAAGNWLFGPL"
     misc_feature    complement(9484..9499)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.71"
                     /tool="antismash"
     gene            10001..11002
                     /locus_tag="BKM31_RS29545"
                     /old_locus_tag="BKM31_29285"
     CDS             10001..11002
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541535.1"
                     /locus_tag="BKM31_RS29545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_29285"
                     /product="terpene synthase family protein"
                     /protein_id="WP_080047057.1"
                     /sec_met_domain="T1TS (E-value: 2.1e-47, bitscore: 162.0,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTTTGTTVFAAVRSTVRTALRSALTSLLPLPRRGGSAALALLP
                     LTERVPAMAAPCRMHPAVYAIEAAVIDWARRTGLRADPGVGYHRMAGRAFAEFDAAAAA
                     LFAQWLTWLFHLDDELDEHSGPLEIFHGMLKGSSRHPLEAAFADLWRVTSVRMSDRWRA
                     RFAVGLQRQYDACRAEAENRAAGRMPTLEEYPALRRGTVGPYLYDLVEPCLRVEVPVWL
                     HESDPWRQLVDACSDVTAWCNDVASRPKERGDVHNFVVLAMRQLGLGEREATAWVLDRI
                     AGRCLDMRKAARRLPLDDLEPKTARDVSKVACAYLAAPRAHLDWLLESQRYA"
     gene            complement(11044..12018)
                     /locus_tag="BKM31_RS29550"
                     /old_locus_tag="BKM31_29290"
     CDS             complement(11044..12018)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541534.1"
                     /locus_tag="BKM31_RS29550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_29290"
                     /product="DUF5937 family protein"
                     /protein_id="WP_080041246.1"
                     /transl_table=11
                     /translation="MSITWVLTPDDVARIRFAFSPLWELVASLRTLQQPARQSIHLPWI
                     KAVRPRLAGLDLSELFALVPPTGYLADFITPPPDTPLPDFAAELDRVRRTDPEQARREI
                     GRIQGTDPAALARFAADPAAGVSRVADALETYWEECFAEFWPRVYALLERDVLRRSRQL
                     ARGGARELFAGLDPAVVWTGERLLIDRPWCADGGLNGDGLILVPSAFYWPAVAVMTAPY
                     QPMLVYPVHGVGTLWEQGPPPAPGALSALIGRSRAAILLALAEPATTSALAARMALTPG
                     AVSQHLGVLSGGGLAVGMRIGKQVVYRRTLAGDMLAAGPAPHA"
     gene            12078..13289
                     /locus_tag="BKM31_RS29555"
                     /old_locus_tag="BKM31_29295"
     CDS             12078..13289
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889321.1"
                     /locus_tag="BKM31_RS29555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_29295"
                     /product="MFS transporter"
                     /protein_id="WP_080041247.1"
                     /transl_table=11
                     /translation="MSSSTVEKTSFLKAQVAGLPRPFWALWGGTLVNRLGTMVMPFTGV
                     YLTQSRGLSVAAAGLVMGLFGAGSLLSQLVAGVLTDRIGRRATLSGGMLATAVCMLALG
                     YSTSLPAILASMFALGLVVDVYRPASSALVADLVSPEERPRAYGLLFWAINLGYSVGMT
                     AGGWLAGLGFVWLFWIDALSSVVFAVLVWRAVPETRPETRQKTGGFGVVLRDRVMVGFT
                     LVVLGNALVYAQTMTMLPVAMTGVVKLSSQEFGLAMAMNGILIVIVQPLVSGRLGRMDP
                     ARTFALGVAVMAAGFAMTAFVTSTLGLAVTIAIWTAGEIITAGIPGAIVAALAPPELRG
                     RYSGLFGLAWSLAAVLAPLAGGPLLELGPRVLWFTIGGVGLAAAAGMLLLGPAVRRRDP
                     VSSL"
     gene            13382..13834
                     /locus_tag="BKM31_RS29560"
                     /old_locus_tag="BKM31_29300"
     CDS             13382..13834
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BKM31_RS29560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BKM31_29300"
                     /product="hypothetical protein"
                     /protein_id="WP_155128182.1"
                     /transl_table=11
                     /translation="MRRAGLARGVAIGMATLAVVFELTDIWVTAQLPQPSWTPLPLAPE
                     DMAGTAFSVFGAILVHSRPRLVIGWLLCAGGLSAAANILTANTFHLLHGDPAAGRPIIN
                     LTWHVLQLTLGVLLPSSTRRAGCCRGAGAGWSCWPWRAWPSTGPAC"
     gene            13783..15240
                     /locus_tag="BKM31_RS29565"
                     /old_locus_tag="BKM31_29305"
     CDS             13783..15240
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012887325.1"
                     /locus_tag="BKM31_RS29565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_29305"
                     /product="sensor histidine kinase"
                     /protein_id="WP_080041249.1"
                     /transl_table=11
                     /translation="MVVLAVAGMALDWAGVLSGQGALRHPAHWTVSAAMTLAFVSLVVR
                     FARGDATERRQLLWVMVTLPGLLVPWVLGDPFWWLATLFIPLIPAAIAVAVLRYRLFGI
                     DTLISRALIGTGLIIVTTGVYVAASAASSIFLAEVDRVAGVAAAVFAGAAFQPMRRGMQ
                     RGIDRLLYGSTGVPGTLARRLRHRLQHADPVHGLLATLDTLREGLSVTGVTVELDGAVT
                     TSGTVSAGAPARVIPLVWHGEPVGLLLVGPTDRRRFPAAHDERVLATLTPYIADAAHAV
                     RLTAALQRSRERILTAREEERRRLRRDLHDGLGQSLTGMAMSINAARLSVRTAPERADL
                     LLAELRAGMDAVSGDIRQLVYGLRPPALDELGLAGALAELAGAPVEVSGRLDGLPAAVE
                     VAAYRIVQEALTNARKHAGAATITVALRRGETLRITVTDDGSGIPADARPGVGLGSMRE
                     RAAELGGTCVVRDAAGGGTVVEAELPL"
     gene            15301..16749
                     /locus_tag="BKM31_RS29570"
                     /old_locus_tag="BKM31_29310"
     CDS             15301..16749
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889319.1"
                     /locus_tag="BKM31_RS29570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_29310"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_080041250.1"
                     /transl_table=11
                     /translation="MLTFTALGPFQAWADGAPLDLGGQRQRAVLARLLVAGGRAVPVHT
                     LIDELWPGEPPAQALSTIQGYVSRLRRALEPGRAPREEAGVLVSAPPGYALRARTEQVD
                     AWHFESLAKSDGPPARVWEAMESALGLWRGPALAEFAELSWAATEAGRLEELRLIAVER
                     RADAGLALGRATALVADLEAHASAYPLREEAWRLLAVALYRMGRQGDALAALRRARAVW
                     RDELGLDLSAGLKRLEADMLAQRLEEPPVAVTDPVVESPVDGPVLRVLVADDQALVRTG
                     LKAMLDSEAGFALAGEAANGEEAIAGVRATRPDVVLLDIQMPRLDGLAAARRILAGERP
                     PKVVMMTTFGSDENLYAALRAGVSGFVLKTSPPEQILAALRAAAAGDALIDPAVTTRLI
                     SAFTGRPDPDSPPALAGLPDDRLDVLKLVARGLTNRQIGQTLALPEEEVGLVVKSLLEH
                     LGLFDRAQLVMAAYESGLVTPGGK"
     misc_feature    16755..16775
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: medium, score: 30.4"
                     /tool="antismash"
     misc_feature    16764..16777
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.71"
                     /tool="antismash"
     misc_feature    complement(16765..16778)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.63"
                     /tool="antismash"
     misc_feature    complement(16766..16779)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.01"
                     /tool="antismash"
     gene            16802..18577
                     /locus_tag="BKM31_RS29575"
                     /old_locus_tag="BKM31_29315"
     CDS             16802..18577
                     /EC_number="6.3.5.1"
                     /GO_function="GO:0003952 - NAD+ synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0009435 - NAD biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541531.1"
                     /locus_tag="BKM31_RS29575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_29315"
                     /product="NAD+ synthase"
                     /protein_id="WP_080041251.1"
                     /transl_table=11
                     /translation="MAQLRIALAQTNPTVGDLSANADKLIAWTRDAAEREAHLVVFTEM
                     FLTGYPVEDLVLRTSFVDASIRTLEEVARRLEREGLGDLPVVVGYVDRAGLAPRVGQPK
                     GAPLDAAALLHKGAVVTRTAKHHLPNYGVFDEYRYFVRGDRLPIFRLHGVDVAIAVCED
                     LWQEGGPVSVVGQAGAGLLVVPNASPYEKEKDDVRLELCVRRAREAGCGLVYVNQVGGQ
                     DELVFDGDSIVVDGAGELVARAGQFKEELLVVDLDDLPVSDAEPGTYPYDAGDGSTITV
                     ERLVLSSEPVAPYPPVPAAVPERLDLHAEVYSALVLAVRDYVAKNGFQSVILGLSGGID
                     SALTATIASDAIGPSRVNVVLMPSRYSSDHSLADAQELVRRQGVNAQVVPIADIVNAFE
                     KEIDLSGLAAENLQARVRGMILMGLSNEHGHLVLTTGNKSELATGYSTLYGDSAGGFAP
                     IKDVPKTMVWELSKWRNAHSDPDFLLQAERPIPENSIEKEPSAELRPDQRDTDSLPPYE
                     VLDRLLDDYVEKDMGSQELIAAGHDPALVTRVIRLVDLAEYKRRQYPPGPKITPKNFGR
                     DRRLPITNRWRETTG"
     gene            18621..19067
                     /locus_tag="BKM31_RS29580"
                     /old_locus_tag="BKM31_29320"
     CDS             18621..19067
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009082053.1"
                     /locus_tag="BKM31_RS29580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_29320"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_080041252.1"
                     /transl_table=11
                     /translation="MAAEACGDDACRDSARGVEAAGARLDEVAGAVADPVRRQILELLL
                     RGGPRPAGDVAERFAISRPAVSRHLRVLRRSGLVRDELVGRQRLYTLDPGPFEELVAWL
                     GPFVRPSGWEHRLDALETEVYRTRRERRTRGDAGQGVTGQESTA"
     gene            19064..19567
                     /locus_tag="BKM31_RS29585"
                     /old_locus_tag="BKM31_29325"
     CDS             19064..19567
                     /NRPS_PKS="Domain: Polyketide_cyc2 (19-112). E-value:
                     7.1e-08. Score: 24.9. Matches aSDomain:
                     nrpspksdomains_BKM31_RS29585_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017564070.1"
                     /locus_tag="BKM31_RS29585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_29325"
                     /product="SRPBCC family protein"
                     /protein_id="WP_080041253.1"
                     /transl_table=11
                     /translation="MSLTPTGRLFSTEHGTDLVLTRTFRAPAEDVWASLTEPERTARWF
                     GPWEGDAEPGGTVKVRLVFEDQQPWYDLRIDACEPPRRLAVSSLDEHGAWHLELVLEEA
                     GGVTELRFVQHLDTTDGVGEIGPGWEYYLDLLVASRDGSPAPGFDAYYPSMRAYYTELA
                     APGR"
     aSDomain        19121..19399
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BKM31_RS29585_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="7.10E-08"
                     /label="BKM31_RS29585_Polyketide_cyc2.1"
                     /locus_tag="BKM31_RS29585"
                     /protein_end="112"
                     /protein_start="19"
                     /score="24.9"
                     /tool="antismash"
                     /translation="LTRTFRAPAEDVWASLTEPERTARWFGPWEGDAEPGGTVKVRLVF
                     EDQQPWYDLRIDACEPPRRLAVSSLDEHGAWHLELVLEEAGGVTELRF"
     gene            19627..20694
                     /locus_tag="BKM31_RS29590"
                     /old_locus_tag="BKM31_29330"
     CDS             19627..20694
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BKM31_RS29590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BKM31_29330"
                     /product="hypothetical protein"
                     /protein_id="WP_080041254.1"
                     /transl_table=11
                     /translation="MAQPLKDLINERSVAVLADGLSAAWPAFPRARFTARALTGLDGLE
                     LKARVTHVAAALHDALPLPYPEAAALVRECAATLDMWSGWPATEHTATHGLGHLDDAMR
                     TLAALTPYATGEFAVRPYLERYRDDAIKIMLEWAESPDEHLRRLASEGSRPRLPWASRV
                     GWLMTPGPTLPLLDRLRDDPSEYVRRSVANHVNDLAKDHPQVALELLAKWRAGGGSHVE
                     RVLRHAVRGLLRAGHPEALALVGATPGSGAVDALSLDSATVAVGAKLAFTVTVTAETAG
                     PVLLKYAVRRAGSRRVFHLGQREASRPGQTFTVRKTHSFRPVTTRDEPPGARELDVIVN
                     GRVAATVPFTLTPAS"
ORIGIN
        1 acgctcgggt cgccctgcgc cgggatcgac acgctgacca tcgcctgccc catcagcttc
       61 accagggcgg gctcgctcag cagctccgtc acgcacggca ccgggtcgcc gcccgtgcac
      121 tgctgcttca gctcgttgta cgcgtcgggc cccgcctccg tcacggccgt caccgaggcg
      181 cggaaggcgt tgtcgcgcag cagcgtcttg gcgtactcga agccgtccat ggagaacagc
      241 agcgtcacca cgacgcccag cagggccacc gcccacttga cgtagcggcg gtagagcatg
      301 gacagccgct gcatctcgcc gtcgaaccag gtctccaccc ccttcctgaa ccggtcgagg
      361 tcgccctgcg cgctctccca cacgcccttc aggtggccgt agagcgggct gtcgatgcgc
      421 tgcagcttgt tgaggaactc ggggatgttc ccgttctcgg tcgcggccag ctccatcacg
      481 gccaccgcga accgctccgg cgggatgttc gcgatgctcg tcctgccgcg cttgcggtgg
      541 tcgatctccc gtacccgcgc gtacaggagg ttcatcatgg agtcgctggt cttcgtcgcg
      601 ggcatctcgc cggggtcggc gggcgccggc tggttgctgt gcttcggacg ggggtcgggg
      661 ccgaacggca gcgcgaccag cacgtcacgg aggctgccgg gcagccacga cggcgccttg
      721 tccccgactc cgtccagggt gtccctgagg taggcccaca ggaacttgct gcggatggac
      781 agcacccgca cgaacgcctc gttgaggccg ctcaccagca gcgacagcag caggaacgcc
      841 accaccaggc cgagggccag atccacgtat acggataaca ccgcgccttg atacacccac
      901 gccgtgtatc agcgcaatga cgcacggcat tgcgcggaag gggtcaggcg ccgtagaaga
      961 cccggtccat gactttgcgg gcgcggcggg tgacgcgccg gtagtcgtcg aggaagtcct
     1021 cggagccgtc gggcgggtag ccgagggtct gcgcgagcat ccggcgctct cccccgtcgc
     1081 gcgggacgct gtcgccggga cggcccttca tcagcatgat cgcgtcgcgg acccgcgagg
     1141 cgaaccgcca ggactccgcc agcaccgcct cgtcgtccgg atccagcagc ccctccccca
     1201 cggcggcccg cagcgcctcc agcgtgcggg tggtgcgcag ggacgggcgc tcgccggcgt
     1261 ggcagagttg gaggagctgg gccacccact ccacgtccga cagcccgccg ggcccgagct
     1321 tggtgtgcag ggcggggtcg gcgccgcgcg gcagccgctc ggcctccatg cgggccttga
     1381 gccgccggat ctccctgatc gcgtcgtcgc gcaggccgct ctgcgggtag cgcagctcgt
     1441 cgatcatggc ggtgaacgcc gcccccagct cggcgtcgcc ggccgagaag cgggcccgca
     1501 gcagggcctg cgcctcccac ggcgccgacc agcgggagta gtaggcgcgg taggaggcca
     1561 gcgtgcgcac cagcgggccc tggcggccct ccgggcgcag gtcggggtcg atgagcaggg
     1621 gcgggtcggg ggcgggcagc gacagcaggc ggcgcagctc gttggcgacg gcgaaggcgg
     1681 cgtcgccggc ctcccgctca tcggccccgg gccgcggcga gtgcacgaac atgacgtcgg
     1741 cgtcgctggc gtaggagcac tccatgccgc ccagccggcc catcgcgatg atcgcgaagg
     1801 aggtgacggg cgggaccttg ctgagcgcgg cgtcgagcgc ggcctggagg gtcacgtcgt
     1861 tgagccgcga cagggcggtg ccgacggtct cgatgtcgat caggccggag atgtcggcca
     1921 cggcggtgcg gaacagctct ttgcggcgca gcgcccgcac cgccgtgacg gcgccctcgg
     1981 ggtcgccggc gtagcgggac acggcggcgg acgcctcgcc gagcagcgac tccggcgggc
     2041 gcacggccag ctcgtcgtcg gagcccagca tcgccaccgc gtcgggggcg tgcatgagca
     2101 ggccggtggc gtagcggctg gtgccgagca cgcgcgccat cctggccgct acggcggtct
     2161 cgtcgcgcag cagccgcagg taccacggcg tgctgcccag cttgtcgctg acctggcgga
     2221 acccgagcag cgcggcgtcg gggtcgggcg tgtcggcgaa ccagccgagc atgaccggca
     2281 gcagcgtgcg ctggatggcg gcccgccggg acacgccggt ggacaggttc gcgatgtgcc
     2341 gcagcgcgcc gcgcggatcg acgtagccga gcgcctccag ccgggccgcc gccgcggcgg
     2401 tggacagccg cgcctccgac tcgggcagcc gcgccacggc ctgcagcagc ggccggtaga
     2461 acagcttctc gtgcagccgc cgcgcctcca tcgcgtgccg ccgccaccgc gccgtgaact
     2521 cgccgacggg gtcggcctgc atgcccagcg cccgccccag cctgcgcaga tcgtcgtcgc
     2581 cggtgggcac gacgtgggtg cggcgcaacc ggtgcagctg cagcaggtgc tcgacctgtc
     2641 gcaggaacgt gtacgcctcc gccagcccgc gcgagtcgtc gcggccgacg tagccgcccc
     2701 gcgacagggc cgccagcgcc gggagcgtgg ccctgcggcg cagcaaaggg tcgagccggc
     2761 cgtgcacgag ctgcaggagc tgcacggcga actcgatgtc gcgcagcccg cccggcccca
     2821 gcttgagctg ccgctcgccc tcggcccgca cgtgggcctc gacgcggcgg cgcatggcct
     2881 gcacgtcctc gacgaagtgc tcgcgggtgg cggccgacca caccatctcg ttgaccgcct
     2941 cgacgtaggc gccgcccagc tccaggtcgc cggccacggg ccgggccttg agcagcgcct
     3001 ggaactccca cgtcttggcc cagcggcggt agtaggcgag gtggctggcc agcgtgcgca
     3061 ccagcggccc cgagcggccc tccgggcgca gcccggcgtc gacctcccac agcgagccct
     3121 cgggggtggt ggcggagcag gcccgcatca tggcctgggc cagccgggtg gcggcgcgca
     3181 gcgccttggc ctcgtcggcg ccctccctcg gctccgccac gaagatcacg tcgacgtcgc
     3241 tgatgtagtt gagctctctg gcgccgcact tgcccatgcc gatgaccgcg aagcgcacct
     3301 cgccggcctc gacctcggtg cgggcgacgg cgagcgcggc ctccagcgcg gcgccggcca
     3361 ggtcggacag ctcggcggtg acctcgccga gcgtggcctg gccggtcagg tcgcgggcgg
     3421 ccaggtgcgc caggcggccc cggtaggcga cgcgcagcgc cgtcagcgcg ccggtgccgc
     3481 cctcggccgc gcgcggctcg ctctcgcccg gctcggcgcc gaccgcccgc agcagctcgg
     3541 ccctggcctc gccgagccgc tgctcggcca ggcgggccac ctggccgggg tggcggacca
     3601 ggtgctcgcc gagcgcggcg ctgacgccga gcacggccag gagcctgccg cgcaggacct
     3661 cgtcggagcg gacggcctcg agcacggccg gctcgcgctc gatcaggcgg atcagcgaga
     3721 ccagcgcctg atcgggatcg gccacctcga ccagggactc caggatgtcg tccaggtcgg
     3781 cctccgactg gcggacgagc tgcgccgccc tgacggcgtc ggcgaagccg agcttcgcga
     3841 ggcgcgcggc ggtggattcg atcctgggca cccctccatc ttgacagctc ttgcgtgttt
     3901 cgccgtaaca tgcgaacgca acgttgcgtt gtgttttgag ggggtcgaga tggcggcagg
     3961 acgggttccg gcaggagtgg cgtgggggtt gctggccgcc tgggcggtgc acgacgccga
     4021 ggagctggcg acgatggcgc ggtggacgcg ggcggcgcgg ccccgcctgg aggagcgctt
     4081 cccgcgggtg ccgtgggagc ggatcgaggt gtcgcaggcg cacgcgagcg tggccatcgg
     4141 gctgatgggc ggggtcatgg ccacggcctc ggcgctgggg gcgcgcacgg gcgggcggag
     4201 cgcgatgttc caggcggcgc tggccgggtt cggggtgcac ggggtggtgc atctcgccca
     4261 ggccgcgctc tttcgcgggt acacgccggg cgtggtgacg gcgccggtcg tcgtgatccc
     4321 gtacgcggtg tgggcgtggc ggcggctgcg gcgggccgga gtgccggcga ccgggcccgg
     4381 ggcggccgtg gcggcgttcc cgctggtcct ggcgggcgtg cacgtcggcg cgcacgccct
     4441 cacctcaggg aggaagaagg tcaggcggga cggccgttcc tgaccgcacg cgaggtggcg
     4501 ctcaggcggg cgtttcggcc cgcacgcgag gtgacgctca ggcggggcgg ccgttcctga
     4561 cgatgtcggc gaacgcgcgc gccaccgggc gccaggtggc caccagcgcg ctctcggcgg
     4621 ccttcacccc ggcgttgagc tcctcggccg tatccaggcc ggagtccgcc gtccacgagg
     4681 cgaagatctc cggcgtggcc tcggggtgga actgcacggc ccaggccgcc tcgccgagcc
     4741 ggtaggcctg gttcgggtac tgggcgccgg tcatcagcgg cacggccccg tcgggcagcc
     4801 gcgtcatggc gtcctggtgg tactggatcg ccacggcggt ggtgatgccc gacagcaggg
     4861 ggtcggtggc ggcggcgggc agcgcgacga cctcgcgggc gcccacctcc agcccgttgc
     4921 cgccgcgctc caccgtcccg ccgcacgcca gggtgagcag ctgcgcgcct aggcagatgg
     4981 ccagcgtggg ggttgcgtcg tcgacggcgc ggcgcagcag gtcgcgggtg gcgggctgcc
     5041 aggggctgcg ctcgtcctcc caggccgccg ccgcgccgcc gagcacgacg agcccgtccg
     5101 ccgcccgctc ggggacctcc tcccccaggt acggccgcac gacctcgcag gcgacgccga
     5161 gccactgcgc gaggtaaccg agcccggcct cggcctcatg ttcgatgacg gtgattcgca
     5221 tatgaggaat tatgtggaga ttatgaggat tgacgaggtc ggcggtctgc ggatcgccac
     5281 gttcggaacg ggaccgcgca cgatcatcgc cgtccacggc atcaccgcct cgctcatggc
     5341 ctgggccggg gccgggcggc ggctgccgga gggctggtcg ctggtggcca tggacctgcg
     5401 cgggcgcggg cacagcgcgg gcctgcccgg cccgtacggg ctgcccaggc acgccgagga
     5461 cgtgctgcgc gtggccgacc acgtcggagc cggcccggac gcggtgctga cgggccattc
     5521 catgggcgcg tacgtggcgg cgctcgccgg cgcccagcgc gagttcgcca gggtcgtgct
     5581 ggtggacggc gggatcccgc tggcgccgat ccccgagggc acggaccccg acgcggcact
     5641 ggaggcggcg ctcggcccgg cgctggcccg gctgcggcag acgttcccgt cggcggaggc
     5701 gtacgtggac ttcttcaagg cgcacccggc cttcgccggc cgctggaacg ccgacgtcga
     5761 ggcgtacgtg cgctacgacc tgacgggccc cgaaggcgcg ctgcgctccc gcgcggcggg
     5821 cgaggcggtg ctggccgacg gccggtggct gcacctggag cgggaggcca tcggggcggc
     5881 gctgacggcg atcaaggcgc cgctgttcct gctcagggcg ccgcgcgggc tgctcgacca
     5941 ggagacgggg atgctgcccg acgacctggt gcggccctgg aaggagcggc tgccggggct
     6001 gcgcgacgag gtggtgcccg actgcaacca ctacacgatc ctgttcgacg agcgctgcgt
     6061 ggccaccgtc gtggaccggc tgaccgccta gaacggcgaa ggcccccgag agcggctcgg
     6121 gggccttggt ccgttcgtca aagggagccc agaaagagag ctcaaaaagg aagctcagcg
     6181 tggagcgatc cacgtggcgc gggcggcggc gaccagcgtg ccgtccacct cgtagatggc
     6241 gctctggccg aacatcttgc ggccgtcgcg cccggtcggg cgggccacca ccgagtagcg
     6301 gccacccggc agcaccgggc ggtggatctg cacggccagg cggccgagca gggcgctctc
     6361 accggggccg aagtgcgccc agccggtgat gcagtcgagc accgcgccga cgatggaggc
     6421 gggcacgccg tcctcgccgg tcacggtgaa cggcacccgc cagccggccg ccacgaggtc
     6481 gctgccctcc accgggccgg ggaagatccg caggccgtca ccgggctcgc gcaggccgca
     6541 ggcgaagcac tccgcgaacg ggtgcgcctt gagccccgcg aacccggcct cggcgcgggc
     6601 cgcgtcgttg aacggcacga acccggggcc ctccagctcc tcggccacgg ggatcgcctc
     6661 gacgagcagc ttgtcgccgt gcgagaggga caccgtgttg gccacgtgct ccagccgcag
     6721 ctcggtctcc agcggcgtgg gggcgtgcaa cgtgacctcg acggctgatc ggccaccgtt
     6781 cagcgcctcc gccatggtgc ccgcgatcca gccgccgttg gcgacgccca cgggaccacg
     6841 gaagcgctgg ggaacggtca acacggtctg cagggcagcc gtcgtcatgc cacaccctcc
     6901 tatatcgcca cacaaggcga gaagtccgga aatatcataa agagcaggcc gattttactg
     6961 gactcccggt ttacctagga tgcgggggtc cggtggctgc tcggtacgtc tccataacgc
     7021 cttgaagggg cccgaaactt cccccaccgg gtaacgagac gctaggcgcc gcggatcacg
     7081 cggatgtgac tcgggggtca gaagcaacga aaatcggccc cactcggaaa ccgctccggg
     7141 agtgaggccg atcaaggcgt tggcagtacc ttaacgaggt ttcccggccg ccgcgaccaa
     7201 acggcggatt ctcgccgatc acggagcggg gtgcgcgtct cggcccatcc tcggagaggc
     7261 tggtaccacg cgccctatgc tggcgcggca ggggtaggta cggcggatcg ggcggaaggg
     7321 tgttgcgtgt ggagggggcg aggcttcggt acccgccggg ggccctggtc atcctgacgg
     7381 ggctgccggg agcgggcaag accacgctgc tgcggcgcct gtacggcatg cacggcgccg
     7441 agagcctgcc cgtgacctcc ggcgcggtgg cggtgatcga ctcggcgcag tcgaagcggc
     7501 actggcaggg ccggctcgcg tgggcgccct acccggtgcg ccgcgcggtg gtgttcgtca
     7561 cccatgtgac gcgcatccgg caggccctga cgcaggggca cgcggtggtg gcgcacaacc
     7621 ggggctgcgg cccgtacgtg ctgcggggtt tcgcctggct ggcgcgccgg cacggcgcgg
     7681 acttccacct gctcctgctc gacgccccgc cggacgaggc gctggcgggg cagcgggcca
     7741 ggggccgggt ggtggcggcc cgcacgttcg cccggcatca gcgcaggtgg gacagcctgc
     7801 tcgcgcgggt gaagggcggc gacccggctc cggcggccgg ggcgcgcatc atggaccggg
     7861 cggaggccgg gctgctggag gcgatcgtgt tcgactcgat cagcggcacc ggcccgcgcc
     7921 ggccgtcgcg gacgtaggtc agagcacggg caggtagcgg ccgagctcga actcggtgac
     7981 gtggcggcgg tactcgcgcc actcgctgcg cttgttgcgc aggaagaagt cgaagacgtg
     8041 ctcgcccagc gtctcggcca ccagctcgct gcgctccatg acctcgatcg cgtcgttgag
     8101 cgagccgggc agcggctgga tgccgagggc gcgccgctcg gcgctggtca gggtccagac
     8161 gttgtcctcg gcggcgggcg gcaggtcgta gctctcctcg atgcccttca gcccggcggc
     8221 caggatcagc gcgaaggcca ggtaggggtt gcaggcggag tcgagcgagc ggaactcgat
     8281 gcgggtcgag ccgcccttgt gcggcttgta catgggcacc cggaccaggg ccgagcggtt
     8341 gttgtggccc cagcacacgt aggagggggc ctcgccgccc agcccggcga tggcctcggc
     8401 gccgccccac agccgcttgt aggagttgac ccactggttg gtgacggcgg tgatctcggc
     8461 ggcgtgccgc agcagccccg cgatgaacga gcggccgatc ttggacagcc ggtagtcggt
     8521 gcccgcctcg tagaaggcgt tgcggtcgcc ctcgaacagc gacatgtgcg tgtgcatgcc
     8581 ggagccgggg tgctcggtga acggcttggg catgaacgag gcccagatgc cctgctccag
     8641 cgcgacctcc ttcatgacca ggcggaaggt catgatgttg tcggccgtgg tgagcgcgtc
     8701 ggcgtagcgc aggtcgatct cctgctggcc gggcgcgccc tcgtggtggc tgaactcgac
     8761 ggagatgccc atcgactcga gcatcatgat cgcctggcgc cggaagtcgt ggccggagct
     8821 gtggggcgtg tggtcgaagt agccgccgga gtcgatcggc tcgggccgct ggccgggctc
     8881 gggacggttc ttcagcagga agaactcgat ctcggggtgg gtgtagaagg tgaagcccat
     8941 gtcggcgcac ttggcgagcg tgcgcttgag cacccagcgc gggtcggcgt gcgacggcgt
     9001 gccgtcgggc atgaggatgt cgcagaagat gcgcgccgcg cccggcgtct cgctgcgcca
     9061 cggcaggatc tggaacgtgg ccgggtcggg cttggccagc atgtcggact cgtagacgcg
     9121 ggcgaagccc tcgatggccg acccgtcgaa cccgatgccc tcggcgaagg ccccttccag
     9181 ctcggcaggc gcgatcgcga cggacttgag gaagccgagc acgtcggtga accacagccg
     9241 gatgaaccgg atgtcgcgtt cctcgagtgt gcggagcacg aactcctgct ggcggtccac
     9301 agcatcccct cgttcgacgg acggtatcgg gtcacacacc agcatgccgt gtccgtgttt
     9361 cgcacacgtt acggggggtg ccggtgcgag cctcgctgac aaagggcccg ccccgactta
     9421 ctgtgatcac gcagtcagtc tcgggggagg cattggtggc catcgacctg ctcaatcaca
     9481 agctcgatcg ggcgttcgac cacatcgacg cgagcggcaa cggcgtcgtc gagcgcgagg
     9541 acctgctggg gctgggcgcc cgcatcctgg tgggcttcgg ggagtccccc acgtcggtca
     9601 ccggggcgag tctcgtggaa agcttcgacc gcatctggtc caccctgtcg gagacgctgg
     9661 agcgcgacgg cgactccggc atcgcgcgcc ccgacttccg caggggcatg acggcggcgt
     9721 tcgtcgaggg cgaccgctac gacgcggtgt tccggccggc cacggtcgcg gtggcggagc
     9781 tgtgcgacgg cgatgacgac gggcagatcg ggccgggcga gttccggacc atgctgtgcg
     9841 cgttcggggt ggcctacgac gacgtggacg aggcgttcga ccggctcgac cgggcgggca
     9901 ggggcgcgct gaccgtggag gagctggtcg tggccgccgc cgactactac cgcggcgacg
     9961 accccaacgc cgccggcaac tggctgttcg ggcccctgtg atgaccacca cgacgaccgg
    10021 caccaccgtg ttcgccgccg tgcgcagcac ggtgcgcacc gcgctgcgct ccgcgctgac
    10081 gtcgctgctg ccgctgccgc gcaggggcgg ctcggccgcg ctggcgctgc tgccgctgac
    10141 cgagcgggtg cccgcgatgg cggcgccgtg ccggatgcac cccgccgtgt acgcgatcga
    10201 ggccgcggtc atcgactggg ccaggcgcac cggcctgcgc gcagacccgg gggtcggcta
    10261 ccaccggatg gcgggccggg cgttcgccga gttcgacgcg gccgcggcgg cgctgttcgc
    10321 gcagtggctc acctggctgt tccacctgga cgacgagctg gatgagcact cgggcccgct
    10381 cgagatcttc cacggcatgc tcaagggcag ctcgcgccac ccgctggagg cggccttcgc
    10441 cgacctgtgg cgggtgacga gcgtgcggat gagcgaccgc tggcgggcca ggttcgcggt
    10501 ggggttgcag cgccagtacg acgcctgccg cgccgaggcg gagaaccgcg cggcgggccg
    10561 gatgccgacc ctggaggagt acccggcgct gcgcaggggc accgtggggc cgtacctgta
    10621 cgacctggtg gagccgtgcc tgcgggtgga ggtgccggtg tggctgcacg agtcggaccc
    10681 gtggcggcag ctcgtggacg cctgcagcga cgtcaccgcc tggtgcaacg acgtggcgtc
    10741 gcggccgaag gagcgcggcg acgtgcacaa cttcgtggtg ctggcgatgc ggcagctcgg
    10801 gctcggcgag cgggaggcga cggcctgggt gctcgaccgg atcgcggggc gctgcctcga
    10861 catgcgcaag gcggcccggc ggctgccgct ggacgacctg gagccaaaga cggccaggga
    10921 cgtcagcaag gtggcgtgcg cgtacctggc ggcgccgcgc gcccacctgg actggctgct
    10981 ggagtcccag cgctacgcgt aggggactcc cgggcgtagg gggctctcag gcgtgggggg
    11041 ctctcaggcg tggggggcgg ggccggcggc gagcatgtcg ccggccaggg tgcggcggta
    11101 gacgacctgc ttgccgatgc gcatgccgac cgcgagcccg ccgccgctga gcacgccgag
    11161 gtgctggctg accgcgccgg gcgtgagcgc catgcgggcg gccagcgcgg aggtggtggc
    11221 gggctcggcg agcgcgagca ggatcgcggc ccggctcctg ccgatcagcg cggacagcgc
    11281 gccgggcgcg ggcggcgggc cctgctccca gagcgtgccg acgccgtgca cggggtagac
    11341 gagcatcggc tggtacggcg ccgtcatcac ggccacggcg ggccagtaga acgcgctggg
    11401 cacgaggatg agcccgtcgc cgttgagccc gccgtcggcg caccagggcc ggtcgatgag
    11461 cagccgctcc cccgtccaca ccacggccgg gtcgagcccg gcgaacagct cgcgggcccc
    11521 gccccgggcg agctgccgcg agcggcgcag cacgtcccgc tccagcagcg cgtacacgcg
    11581 gggccagaac tcggcgaagc actcctccca gtacgtctcc agcgcgtccg cgaccctgga
    11641 cacgccggcg gcggggtcgg cggcgaagcg ggccagcgcg gccgggtccg tgccctggat
    11701 ccggccgatc tcccggcgcg cctgctcggg gtcggtgcgc ctgacccggt cgagctcggc
    11761 ggcgaagtcg ggcagcggcg tgtcgggcgg cggggtgatg aagtcggcga ggtagccggt
    11821 ggggggcacg agcgcgaaca gctccgacag gtcgagcccg gccagccggg gccgcacggc
    11881 cttgatccag ggcaggtgga tcgactgcct ggcgggctgc tggagggtgc gcaggctcgc
    11941 caccagctcc cacagcgggg agaacgcgaa ccggatgcgc gcgacgtcgt cgggcgtcag
    12001 cacccacgtg atggacatgc ttttagtctg cgctaaatcg ttcgccggac aaagccggaa
    12061 atctcactct ttgaggcgtg tcgagctcta ccgtcgagaa gacctctttc ctcaaggcgc
    12121 aggtcgccgg gctgccccgc ccgttctggg ctctttgggg cggcacgctg gtgaaccgcc
    12181 tggggaccat ggtgatgccc ttcacgggcg tctacctcac ccagagccgc ggcctgtccg
    12241 tggccgccgc gggcctggtg atgggcctgt tcggggcggg ctcgctgctg tcgcagctcg
    12301 tggcgggcgt gctgacggac cgcatcgggc ggcgggccac gctgtcgggc ggcatgctgg
    12361 ccaccgccgt ctgcatgctg gcgctgggct acagcacctc gctgcccgcg atcctggcct
    12421 cgatgttcgc gctcggcctg gtggtggacg tctaccggcc ggcttcgagc gcgctggtcg
    12481 ccgacctcgt ctcccccgag gagcggcccc gggcgtacgg gctgctgttc tgggcgatca
    12541 acctcggtta ctcggtgggc atgacggccg gcggctggct ggcggggctc gggttcgtct
    12601 ggctgttctg gatcgacgcg ctgtccagcg tggtcttcgc cgtgctggtg tggcgggcgg
    12661 tgccggagac ccggccggag acgaggcaga agaccggcgg gttcggggtg gtgctgcgcg
    12721 accgggtgat ggtcgggttc acgctggtgg tgctgggcaa cgcgctggtc tacgcgcaga
    12781 cgatgaccat gctgccggtg gcgatgaccg gcgtcgtgaa gctgtcgtcc caggagttcg
    12841 ggctggccat ggccatgaac gggatcctca tcgtcatcgt gcagccgctg gtgtccggcc
    12901 ggctggggcg gatggacccg gcgcgcacgt tcgcgctggg ggtggcggtg atggccgcgg
    12961 ggttcgcgat gaccgcgttc gtgaccagca cgctcgggct ggcggtgacg atcgccatct
    13021 ggacggccgg cgagatcatc acggccggca tcccgggcgc catcgtggcc gcgctggcgc
    13081 cccccgagct gcgcgggcgc tactcggggc tgttcgggct cgcgtggtcg ctggcggcgg
    13141 tgctggcgcc gctggccggc gggccgctgc tggagctggg gccgcgggtg ctgtggttca
    13201 cgatcggcgg ggtcggcctg gcggccgccg ccgggatgct gctgctgggg cctgccgtgc
    13261 gccgccgtga cccggtatcg tcgctctgac caggtgcgga gcgcgttgag aaaattttga
    13321 tcggacgttg gcagcccacc gataattttc acccggtcac ggggtgggaa gggcggatgg
    13381 gatgcgccgc gcaggtctgg cgcgaggcgt ggcgatcggg atggccacgc tcgccgtggt
    13441 gttcgagctc accgacatct gggtgacggc acagctgccc cagccgtcgt ggacgccgct
    13501 gccgctcgcg cccgaggaca tggcgggcac ggcgttctcc gtcttcggcg cgatcctcgt
    13561 gcacagcagg ccgcggctgg tgatcggctg gctgctgtgc gcgggcgggc tgagcgccgc
    13621 ggccaacatc ctgacggcca acaccttcca cctgctccac ggcgaccccg ccgcgggccg
    13681 cccgatcatc aacctcacgt ggcacgtgct gcagctcacg ctcggcgtgc tgctcccctc
    13741 ctctacccgg cgggcaggct gctgtcgcgg cgctggcgct gggtggtcgt gctggccgtg
    13801 gcgggcatgg ccctcgactg ggccggcgtg ctgagcgggc agggcgcgct cagacacccc
    13861 gcccactgga cggtgtcggc ggccatgacg ctggcgttcg tctcgctcgt ggtgcggttc
    13921 gcgcgcggcg acgcgaccga gcggcgccag ctcctctggg tgatggtgac gctgccgggg
    13981 ctgctggtgc cgtgggtgct gggcgacccc ttctggtggc tggccacgct cttcatcccg
    14041 ctcatcccgg cggccatcgc ggtggcggtg ctgcgctacc ggttgttcgg catcgacacg
    14101 ctgatcagcc gcgcgctgat cggcaccggg ctgatcatcg tgaccaccgg cgtgtacgtc
    14161 gccgccagcg ccgcgagcag catcttcctc gccgaagtgg accgggtggc gggcgtcgcg
    14221 gcggcggtgt tcgccggggc cgcgttccag ccgatgcggc gcggcatgca gcgcggcatc
    14281 gaccggctcc tgtacggcag caccggcgtg cccggcacgc tggccaggcg gctgcggcac
    14341 cggctgcagc acgccgaccc agtgcacggc ctgctcgcca ccctcgacac gctgcgcgag
    14401 ggcctgtcgg tcacgggcgt gacggtcgag ctggacggcg ccgtcaccac gtccggcacc
    14461 gtctccgccg gcgcgcccgc gcgggtgatc ccgctggtgt ggcacgggga gccggtcggg
    14521 ctgctgctgg tcgggccgac cgaccggcgc aggttccccg ccgcgcacga cgagcgggtg
    14581 ctcgccacgc tcaccccgta catcgccgac gcggcgcacg cggtgcggct gacggccgcg
    14641 ttgcagcgct cgcgcgagcg catcctgacc gcgcgcgagg aggagcggcg gcggctgcgg
    14701 cgcgacctgc acgacgggct cggccagtcg ctgaccggca tggccatgtc gatcaacgcc
    14761 gcgcggctgt ccgtgcgcac cgcgccggag cgcgccgacc tgctgctggc cgagctgcgg
    14821 gccggcatgg acgccgtcag cggcgacatc aggcagctcg tgtacggcct gcgcccgccg
    14881 gcgctcgacg agctgggcct ggccggggcg ctggcggagc tggccggcgc cccggtcgag
    14941 gtctccggcc gcctcgacgg gctgcccgcg gcggtcgagg tggccgcgta ccggatcgtg
    15001 caggaagcgc tcaccaacgc gcgcaagcac gccggcgccg ccacgatcac ggtcgcgctg
    15061 cggcgcggcg agacgctgcg gatcaccgtc accgacgacg ggagcgggat cccggcggac
    15121 gcccggccgg gggtcgggct gggctcgatg cgcgagcggg ccgccgagct gggaggcacg
    15181 tgcgtcgttc gcgacgcggc cggaggaggc acggtggtgg aggccgagct accgctctga
    15241 gcacgatgcg atatctcccc atatacccag gcccgttctc cctctacagt tacgcctgac
    15301 atgctgactt tcaccgctct cggaccgttc caggcctggg ccgacggagc ccccctcgac
    15361 ctcggcggcc agcggcagcg ggcggtgctc gcgcgcctgc tcgtcgccgg tggccgcgcc
    15421 gtgcccgtgc acaccctcat cgacgagctc tggccgggcg agcccccggc gcaggccctg
    15481 tccaccatcc agggctacgt ctcgcggctg cgccgcgcgc tggagcccgg ccgcgcgccg
    15541 cgcgaggagg cgggggtgct ggtgtccgcg ccgcccgggt acgcgctgcg cgcccgtacc
    15601 gagcaggtgg acgcctggca cttcgagagc ctggccaagt ccgacggccc gcccgcgcgg
    15661 gtctgggagg ccatggagag cgcgctcggg ttgtggcggg ggccggcgct ggccgagttc
    15721 gccgagctga gctgggccgc gaccgaggcc gggcggctgg aggagctgcg gctgatcgcc
    15781 gtcgagcggc gcgccgacgc cgggctcgcg ctggggcggg cgacggcgct ggtggcggac
    15841 ctggaggcgc acgcgtcggc gtacccgctg cgggaggagg cgtggcggct gctggccgtg
    15901 gcgctctacc ggatggggcg ccagggcgac gcgctggcgg cgctgcgcag ggcgcgcgcc
    15961 gtgtggcggg acgagctggg gctggacctg tcggcggggc tgaagcggct ggaggccgac
    16021 atgctggccc agcgcctgga ggagccgccc gtcgccgtca ccgatcccgt ggtggagagc
    16081 cccgtggacg ggccggtgct gcgggtgctg gtggccgacg accaggcgct ggtgcgtacc
    16141 gggctgaagg ccatgctgga cagcgaggcc gggttcgcgc tggcgggcga ggcggccaac
    16201 ggcgaggagg cgatcgcggg cgtccgcgcg acgcggcccg acgtggtgct gctcgacatc
    16261 cagatgccgc gcctcgacgg cctggccgcc gcccgccgga tcctggccgg cgagcgcccg
    16321 ccgaaggtcg tgatgatgac cacgttcggc agcgacgaga acctgtacgc ggcgctgcgg
    16381 gcgggcgtga gcgggttcgt gctgaagacg tcaccgcccg agcagatcct cgccgcgctc
    16441 cgggcggccg cggccgggga cgcgctcatc gacccggccg tgaccacgcg gctgatctcg
    16501 gcgttcaccg ggcgcccgga cccggactcc cctccggcgc tggccgggct gcccgacgac
    16561 cggctggacg tgctcaaact cgtcgcgcgg gggctgacca accggcagat cggccagacg
    16621 ctggcgttgc cggaggagga ggtgggcctg gtggtgaagt cgctgctgga gcacctcggg
    16681 ctgttcgacc gggcgcagct cgtgatggcc gcgtacgagt cgggcctggt cacccctggc
    16741 ggtaaatgac cggcttttcg tcgctttgac gataaaaatc ggggcgtact aggctggtca
    16801 cgtggcacaa ctccgcattg ccctggcaca gacgaacccg accgtcggcg acctgagcgc
    16861 caacgccgac aaactgatcg cgtggacccg cgacgcggcg gagcgcgagg cccatctcgt
    16921 ggtcttcacc gagatgttcc tcaccggcta ccccgtggag gacctcgtgc tgcgcacgtc
    16981 cttcgtggac gccagcatcc gcacgctgga ggaggtggca cgcaggctgg agcgcgaggg
    17041 cctcggcgac ctgcccgtcg tcgtcggcta cgtcgaccgc gccggcctcg ccccccgcgt
    17101 cggacagccg aagggcgccc cgctcgacgc cgccgccctg ctccacaagg gcgcggtcgt
    17161 cacccgcacc gccaagcacc acctgccgaa ctacggcgtc ttcgacgagt accgctactt
    17221 cgtgcgcggc gaccggctgc ccatcttccg gctgcacggg gtggacgtcg ccatcgcggt
    17281 gtgcgaggac ctctggcagg agggcggccc cgtgtccgtc gtcgggcagg cgggggccgg
    17341 gctgctcgtg gtgccgaacg cctcgccgta cgagaaggag aaggacgacg tacgactgga
    17401 gctgtgcgtg cggcgcgccc gcgaggccgg ctgcggcctc gtctacgtca accaggtcgg
    17461 cgggcaggac gagctggtct tcgacggcga ctccatcgtg gtcgacgggg cgggcgagct
    17521 ggtggcgcgg gccgggcagt tcaaggagga gctgctggtc gtggacctcg acgacctgcc
    17581 cgtctccgac gccgagcccg gcacctaccc ctacgacgcc ggcgacggct ccaccatcac
    17641 cgtcgagcgg ctcgtgctgt cctccgagcc cgtcgccccg tacccgcccg tccccgccgc
    17701 cgtccccgag cggctcgacc tgcacgccga ggtctactcg gcgctcgtcc tcgcggtccg
    17761 cgactacgtg gccaagaacg gcttccagtc cgtcatcctc ggcctgtccg gcggcatcga
    17821 ctccgcgctg accgccacca tcgcctccga cgccatcggc ccctcgcggg tcaacgtggt
    17881 gctcatgccc tcccgctact cctccgacca ctcgctggcc gacgcccagg agctcgtccg
    17941 caggcagggc gtcaacgcgc aggtcgtgcc gatcgccgac atcgtcaacg ccttcgagaa
    18001 ggagatcgac ctgtcgggcc tggccgccga gaacctccag gccagggtgc gcggcatgat
    18061 cctcatgggc ctgtcgaacg agcacggcca cctcgtgctc accaccggca acaagagcga
    18121 gctggccacc ggctactcca ccctctacgg cgactccgcc ggcggcttcg cgcccatcaa
    18181 ggacgtgccc aagacgatgg tgtgggagct gtccaagtgg cgcaacgccc actccgaccc
    18241 cgacttcctc ctccaggccg agcggccgat ccccgagaac tcgatcgaga aggagccgag
    18301 cgcggagctg cggcccgacc agcgcgacac cgactcgctg ccgccgtacg aggtgctgga
    18361 ccggctgctc gacgactacg tcgagaagga catgggctcg caggagctca tcgcggccgg
    18421 gcacgacccg gcgctggtga cgcgggtgat ccggctggtg gacctggccg agtacaagcg
    18481 gcggcagtat ccgcccggcc ccaagatcac gcccaagaac ttcgggcgtg accgccgcct
    18541 gcccatcacc aaccggtggc gcgagaccac cggctgaggc cccttgagga agcgtaacct
    18601 gtaggttacg cttccttggc atggcggccg aggcatgtgg agacgacgca tgtagagaca
    18661 gcgcacgtgg cgttgaggcg gccggggcgc gccttgacga ggtggcgggc gccgtggccg
    18721 acccggtgcg gcggcagatc ctcgagctgc tgctgcgggg cgggccgcgg ccggccggtg
    18781 acgtggccga acgcttcgcg atcagccgcc ccgccgtcag ccgccacctg cgggtgctcc
    18841 ggcgcagcgg cctcgtccgc gacgaactgg tcggccggca acgcctctac acgctcgacc
    18901 ccgggccgtt cgaggagctg gtcgcgtggc tcggcccctt cgtgcgcccg tccggatggg
    18961 agcaccgcct cgacgcgctg gagaccgagg tgtaccgcac gcgccgcgaa cgccgtacca
    19021 gaggggacgc cgggcagggc gtcaccggac aggagagcac cgcatgagcc tcacccccac
    19081 cggccggctg ttcagcaccg agcacggcac cgacctcgtc ctcacccgca ccttccgcgc
    19141 ccccgccgag gacgtctggg cgagcctcac cgagcccgag cgcaccgccc gctggttcgg
    19201 gccgtgggag ggcgacgccg agcccggcgg cacggtcaag gtgcggctcg tcttcgagga
    19261 ccagcagccc tggtacgacc tgcgcatcga cgcctgcgag ccgccccgcc gcctggccgt
    19321 ctcgtccctc gacgagcacg gggcctggca cctggagctg gtgctggagg aggcgggcgg
    19381 ggtgacggag ctgcggttcg tccagcacct cgacacgacg gacggcgtcg gggagatcgg
    19441 gcccggctgg gagtactacc tggacctgct cgtcgcgtca cgtgacgggt cgccggcgcc
    19501 cggcttcgac gcgtactacc cgtcgatgcg cgcgtactac acggaactcg ccgcccccgg
    19561 ccgctgaccg acgccgctcc accatcgcac cctggaattg tcggtggctc ctggcacagt
    19621 ggcccggtgg ctcaacccct gaaagacctg atcaacgagc gctcggtggc ggtgctggcc
    19681 gacgggctga gcgcggcctg gccggcgttc ccgcgcgccc gcttcaccgc gcgggccctg
    19741 accggcctcg acggcctgga gctcaaggcc cgcgtgacgc acgtggccgc ggccctgcac
    19801 gacgcgctgc ccctgcccta tccggaggcc gccgcgctcg tgcgcgagtg cgccgccacg
    19861 ctcgacatgt ggagcggctg gccggccacc gagcacaccg ccacccacgg cctcggccac
    19921 ctcgacgacg cgatgcggac gctggccgcg ctcaccccct acgcgacggg cgagttcgcc
    19981 gtccgcccct acctggagcg ttaccgcgac gacgccatca agatcatgct cgagtgggcc
    20041 gagtcacccg acgagcacct gcgccggctg gcctcggagg gctcccgccc gcgcctgccg
    20101 tgggcgagcc gggtcggctg gctgatgacg ccgggcccca ccctgcccct gctcgaccgg
    20161 ctgcgcgacg acccgagcga gtacgtccgc cgctcggtcg ccaaccacgt caacgacctc
    20221 gccaaagacc acccgcaggt ggccctggag ctgctggcga agtggcgcgc cggcggcggc
    20281 tcccacgtgg agcgggtgct gcggcacgcg gtgcgcggcc tgctgcgggc cggccacccc
    20341 gaagcgctcg ccctggtggg cgccacgccg ggcagcggcg ccgtcgacgc cctgtccctc
    20401 gactccgcca ccgtcgccgt gggcgccaag ctggccttca cggtcaccgt cacggccgag
    20461 acggcggggc cggtgctcct gaagtacgcg gtgcggcggg ccggctcgcg gcgcgtgttc
    20521 cacctggggc agcgggaggc gagccggccc ggccagacgt tcacggtccg caagacccac
    20581 tccttccgcc cggtcaccac ccgcgacgag ccgcccggcg cgcgggagct cgacgtgatc
    20641 gtcaacggca gggtggccgc gaccgtcccg ttcacgctga ccccggcctc gtgacgtacc
    20701 agggagggct tccatgacgg acgcggcacg cgacgtggac ctgctccgga tcgagctggg
    20761 cgtcatctgg cgcctggacg aacgcggccg cctgcccggc ccggagaccc tggtgatcgg
    20821 cgcggccccc gacggcctga ccgccgccgt cgccggccac gtccccgacg acctggccac
    20881 tcacctgctc tccctcatca ccggagccgc cctcccgccc cctggtgtgc ctccgggggt
    20941 cctggccgac tgccgggagc tgctgggtgg cgagcgggtg aaggtgaccg gaggcccgag
    21001 ct
//
