LOCUS       NZ_CP017717            21068 bp    DNA     circular CON 03-MAR-2024
DEFINITION  [Actinomadura] parvosata subsp. kistnae strain ATCC 55076
            chromosome, complete genome.
ACCESSION   NZ_CP017717
VERSION     NZ_CP017717.1
KEYWORDS    RefSeq.
SOURCE      [Actinomadura] parvosata subsp. kistnae
  ORGANISM  [Actinomadura] parvosata subsp. kistnae
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Streptosporangiaceae; Nonomuraea.
REFERENCE   1  (bases 1 to 13047416)
  AUTHORS   Nazari,B., Forneris,C.C., Gibson,M.I., Moon,K., Schramma,K.R. and
            Setedsayamdost,M.R.
  TITLE     Nonomuraea sp. ATCC 55076 harbors the largest actinomycete
            chromosome to date and the kistamicin biosynthetic gene cluster
  JOURNAL   Medchemcomm (2017) In press
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 13047416)
  AUTHORS   Nazari,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2016) Chemistry, Princeton University, 20
            Washington Road, Princeton, NJ 08544, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 18-JUN-2015
            Assembly Method                   :: Celera Assembler v. Jun 2015
            Assembly Name                     :: SmrtPipe 1.87.139483
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 110.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/03/2024 13:15:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 12,000
            CDSs (total)                      :: 11,919
            Genes (coding)                    :: 11,783
            CDSs (with protein)               :: 11,783
            Genes (RNA)                       :: 81
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 136
            CDSs (without protein)            :: 136
            Pseudo Genes (ambiguous residues) :: 0 of 136
            Pseudo Genes (frameshifted)       :: 36 of 136
            Pseudo Genes (incomplete)         :: 98 of 136
            Pseudo Genes (internal stop)      :: 10 of 136
            Pseudo Genes (multiple problems)  :: 6 of 136
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:57:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6379936
            Orig. end                         :: 6401004
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP017717.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21068
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="24"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21068
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21068
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11068](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11068
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(692..707)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: medium, score: 25.32"
                     /tool="antismash"
     misc_feature    693..706
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.64"
                     /tool="antismash"
     misc_feature    697..710
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.91"
                     /tool="antismash"
     misc_feature    complement(732..747)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.11"
                     /tool="antismash"
     misc_feature    733..746
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.74"
                     /tool="antismash"
     gene            complement(867..1058)
                     /locus_tag="BKM31_RS28740"
                     /old_locus_tag="BKM31_28485"
     CDS             complement(867..1058)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1265: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009072605.1"
                     /locus_tag="BKM31_RS28740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_28485"
                     /product="ferredoxin"
                     /protein_id="WP_080047039.1"
                     /transl_table=11
                     /translation="MEIKADTTVCIGAGMCALTVPKVFDQSEDEGTVVVLQDKPPQELE
                     EAVRRAVTLCPSGAISVV"
     misc_feature    complement(1044..1060)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.98"
                     /tool="antismash"
     gene            complement(1065..2264)
                     /locus_tag="BKM31_RS28745"
                     /old_locus_tag="BKM31_28490"
     CDS             complement(1065..2264)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541682.1"
                     /locus_tag="BKM31_RS28745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_28490"
                     /product="cytochrome P450"
                     /protein_id="WP_080041110.1"
                     /sec_met_domain="p450 (E-value: 1.5e-21, bitscore: 76.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSELTLPTARQRPLDPPDEVTALRQQAPIHRMTYADGHQGWLVTG
                     YAAARAVLAGPHFSNRPENNVHPPIRSARMEAAMRPELMRVPPGFFLRMDAPEHTRYRK
                     LLTGQFTVRRMKMLEPRIQEITETCLDAMEAAGPPVDLVQEFALPIPSLVICELLGVPY
                     EDRDRFQADSKLLVNLETKVDDAVAALGRVSAYLHGLIQRKRKEPADDLLSGLLESGEL
                     ADDELTGVGVLLLIAGHETTANMLGLGTYALLTNPAQLAAMRDDPSVVENGVEELLRYL
                     TIIHLGPIRTALEDVEIEGVTIKAGESVTIHLPAANRDASRFPDAERLDVTRPAGGHLT
                     FGHGIHQCLGQQLARAEMRIAYPALLRRLPGLRLAVTPEEVPMRSDMTIYGVHRLPVTW
                     "
     misc_feature    complement(2306..2322)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.91"
                     /tool="antismash"
     misc_feature    complement(2326..2341)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.29"
                     /tool="antismash"
     gene            2361..2966
                     /locus_tag="BKM31_RS28750"
                     /old_locus_tag="BKM31_28495"
     CDS             2361..2966
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012892714.1"
                     /locus_tag="BKM31_RS28750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_28495"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_080041111.1"
                     /transl_table=11
                     /translation="MVEGLRERKKQRTRQALIEAALRLFEEKGFEETTLAEIAEQADVS
                     TRTFFSYFASKEDVVFYDTTARLEAAISAMESRRPDETVTGVLLRIIEESFEQATSYQD
                     LTPADAALRMRLILTEPALQARALLLLFDSQLRLAKGLRDAFPGLTLADAAAAVGALIG
                     AIKLTVMATLDDEQTLEDILATAHRAAEVAISGLRTLG"
     misc_feature    3009..3018
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.92"
                     /tool="antismash"
     gene            3056..3598
                     /locus_tag="BKM31_RS28755"
                     /old_locus_tag="BKM31_28500"
     CDS             3056..3598
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BKM31_RS28755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BKM31_28500"
                     /product="hypothetical protein"
                     /protein_id="WP_080041112.1"
                     /transl_table=11
                     /translation="MATSQGRGGRVGLVLLALGPALVAAYAGAGYVAIKAAVRAQVTGP
                     EWAGRKAGAAGFTSLGVDTWRLTWWTALVVGLVAVLYLLFGVLLRRGSRGRTLILVVSG
                     LLIVPYALGFGVALFNPPAMLANLYDNPDFLAGLPAWQPFTAWLLLAAGLAQAVGMVLA
                     TTRIGRAPAQPRVGSPS"
     gene            complement(3654..4493)
                     /locus_tag="BKM31_RS28760"
                     /old_locus_tag="BKM31_28505"
     CDS             complement(3654..4493)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF017206.4"
                     /locus_tag="BKM31_RS28760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_28505"
                     /product="NmrA family NAD(P)-binding protein"
                     /protein_id="WP_230466411.1"
                     /transl_table=11
                     /translation="MIVVTGVSGALGGAILGGLRAAGGLEVVGASRSGDGTAVRHADFD
                     RPETLKEAFEGARVLVFVSAGYAEDDVVLARHGAVVRAAADAGVEHVIYTSLAASGERL
                     TIALAHRWTEARLAEAPFDVTVLRNGLYAEIPAGLALMGAAAAAESGVFAAPLGAGRVS
                     VAARDDLAAVAVRVAAEAWQDVVSGGERRHAGRTYELEGLSAVGGHDLAEVLSEVLGRP
                     VSYLPVPLGPRGRGWPGWRRTRRVTRCRPSPTSAPACWRPVKAICPRSWTRPVRPAT"
     misc_feature    4482..4497
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.22"
                     /tool="antismash"
     gene            4566..4985
                     /locus_tag="BKM31_RS28765"
                     /old_locus_tag="BKM31_28510"
     CDS             4566..4985
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017543363.1"
                     /locus_tag="BKM31_RS28765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_28510"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_080041113.1"
                     /transl_table=11
                     /translation="MSVAHTEVTPQVEGQVTGPCGDDDCGIRDVLDRIGDKWTVLVLVE
                     LSKGVRRFRELHRAVPGISQRMLTLTTRRLCRDGLVERTAYPTIPPQVEYRLTPMGRSL
                     AEAVRRLADWSREHKDAMDDARARWDAGHGLDSED"
     gene            complement(4993..6690)
                     /locus_tag="BKM31_RS28770"
                     /old_locus_tag="BKM31_28515"
     CDS             complement(4993..6690)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BKM31_RS28770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BKM31_28515"
                     /product="hypothetical protein"
                     /protein_id="WP_155128150.1"
                     /transl_table=11
                     /translation="MTTAFMVDTPAPPVRGRSGAAGARVWWLLAAGWLAQVALRLWLNR
                     YHTMPVANPDETGYLLAARWLAGGAGADLSGSTFYQAGYALLLVPIFWLTSDPALAYRL
                     AVGAGAMAAASAYPAAYVLLRRLRLDRRAALVAAFVAGLSPALLVFSGFALADAILPVV
                     VLAWLTALHDLVAGGAERRRVVAGVVAGGLGAYAMATHLRGTVIVAVCLLVAVALWRRL
                     PRAALIATLASAVAGAVAGDALNAALRAALYPGGPRDLSALLVERLTSVDGQAWALSGA
                     AGQLWYLVTGTWGLAGVGLAGAAALLARRSAPLAPRVLAGALLAATLGIAYASSAALPD
                     EHRVGNFAYGRYLSCVAVAWTLAGLLTLLRARRLAVARCALAAAGLLAVTGGVTAWYAG
                     DRLHRHAFIAFDFPEVIFLTRTFDALDLVTASLSALALLACLTAAALLARPATATPAGR
                     PATAVVGVLALIHLAFIAHLAPSPPAAGPDWLPAPAPPGRVAVEAGVRWNVWVPLSYRV
                     WWTGIERFHGTTPPEGICTAVVQEDAGPPPEGWTVTGARHGWATWSRC"
     gene            complement(6798..7616)
                     /locus_tag="BKM31_RS28775"
                     /old_locus_tag="BKM31_28520"
     CDS             complement(6798..7616)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131599.1"
                     /locus_tag="BKM31_RS28775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_28520"
                     /product="L,D-transpeptidase family protein"
                     /protein_id="WP_230466412.1"
                     /transl_table=11
                     /translation="MRVRRLPGVAALLTAGVVVVSGCGTQHMERPAQTPLPPVPSPAAA
                     QQGPAAAPEAAVTAPRKTLRLGAKGKAVTWMQKRLTELGYRPGKADGQYGGTTLAAVWA
                     FQKVNGIKPTSTIAKRTWEALEAPRAPKVLVPGGKATRAEVNLTKQIMVLYVRGQVKLI
                     THISSGSGIPYCETTTWQGKEQRFCGSARTPTGNYRTTWRVSGWHKSYLGELYNPIFFN
                     GGIAFHGALSVPLYPASHGCVRMPMNVAGELPGLLGKGVPVHVRGAYKRA"
     misc_feature    7627..7644
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.07"
                     /tool="antismash"
     gene            7709..8185
                     /locus_tag="BKM31_RS28780"
                     /old_locus_tag="BKM31_28525"
     CDS             7709..8185
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131598.1"
                     /locus_tag="BKM31_RS28780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_28525"
                     /product="YbaK/EbsC family protein"
                     /protein_id="WP_080041116.1"
                     /transl_table=11
                     /translation="MPEKLPANAVLVESALRALGAAGEIVVLPEKAPTAATAAAQLGCE
                     VGAIANSLIFDADGAPLLVLTSGAHRVDVELIARTAGVRKVRRATPEFVRQATGQPIGG
                     VAPVGHPAPVRTLVDNWLGKHEVVWAAGGHPHTVFPTTFDELVRITGGTPVDVE"
     gene            8196..8765
                     /locus_tag="BKM31_RS28785"
                     /old_locus_tag="BKM31_28530"
     CDS             8196..8765
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541677.1"
                     /locus_tag="BKM31_RS28785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_28530"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_080047040.1"
                     /transl_table=11
                     /translation="MIEFRGAGPAEFAERLDTVIDIYTAAMNPPEDQITGRKTIMRNHA
                     TYPHFQCYFAELRESSPDAPAPEPLTVGFAYGFRGAPGQWWHDVVLRGLEDRMGTEAAN
                     AWMGHAFELAEIHVHPDYQGKGIGRAMIRTLCAGRRERSAVLSTHDQPTAARHLYASMG
                     FTDLLTRFVFPGGSEEYAIAGRPLPL"
     gene            complement(8988..9908)
                     /gene="metF"
                     /locus_tag="BKM31_RS28790"
                     /old_locus_tag="BKM31_28535"
     CDS             complement(8988..9908)
                     /EC_number="1.5.1.20"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="metF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889491.1"
                     /locus_tag="BKM31_RS28790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_28535"
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="WP_080041117.1"
                     /transl_table=11
                     /translation="MALGRSSIRPDRVPTVREMLASGGRSFSFEFFPPKTDEGARQLWR
                     AIRELESLRPTFVSVTYGAGGSTRDRTVDIVERIAHDTTLTPVAHFTAVNHSVRELRHL
                     VGRFADAGVRNILAVRGDPPGDPMGEWVQHPEGVLYAEELVRLIRQAGDFCVGVAAFPY
                     KHPRSPSVESDVEYFVRKCRAGADYAITQMFFQADDYLRLRDRVAAKGCDTPIIPCIMP
                     VTQMSTIARSEQLSGAPFPPDVAARFEAVKDDPAAVRQLGIEHGAELCQRLLDEGAPGI
                     HFITFNRSSASREVFQRLERVPAAT"
     gene            10001..11068
                     /locus_tag="BKM31_RS28795"
                     /old_locus_tag="BKM31_28540"
     CDS             10001..11068
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889490.1"
                     /locus_tag="BKM31_RS28795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_28540"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_080041118.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 7.5e-47, bitscore:
                     159.2, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTHAAGMETLRAQVERALAEFVERKLPSGGDPEFAPLRTAADEL
                     LSGGKRLRPAFCYWGWRGAGGTDEPGVFTAAASLELLQASALVHDDVMDKSDLRRGMPS
                     AHRRFQAMHEKSGWHGSAEQFGEGAAILLGNLLLIWSGEMWRTSGLPREALDAAQPVHD
                     HMRSELMCGQYLDLLEQAHGENTFESALRVALFKSGKYSVEQPLRLGLALAARELTPWM
                     DELCTGYGRRVGIAFQLRDDILGVFGDPAQTGKPAGDDLREGKRTMLVARTLAAASPAD
                     ADTVRLLLGDPGLDEAGVATLRRIIEGTGALQECEDLIGDYLSQALSALESSPVTPEAR
                     KALTELAIAATSRKT"
     gene            complement(11708..12346)
                     /gene="thiE"
                     /locus_tag="BKM31_RS28800"
                     /old_locus_tag="BKM31_28545"
     CDS             complement(11708..12346)
                     /EC_number="2.5.1.3"
                     /GO_function="GO:0004789 - thiamine-phosphate
                     diphosphorylase activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1280: thiamine-phosphate pyrophosphorylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541674.1"
                     /locus_tag="BKM31_RS28800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_28545"
                     /product="thiamine phosphate synthase"
                     /protein_id="WP_080041119.1"
                     /transl_table=11
                     /translation="MPKPSLSEARLYLCTDGRRDRGDLAEFLDSVLAGGVDIIQLREKG
                     LEAREELALLEVFRDACDRHGKLLAVNDRADIAYAARPDVLHLGQDDLPVTVAREILGD
                     DIVIGRSTHSTAEASAAAVEEGVDYFCCGPIWPTPTKPGRPAPGPPLLRHAASLDTPRP
                     WFGIGGIDLANLDEVLSLGVRRVVVVRAITEADDPGAAAAEFAKRLATA"
     gene            complement(12324..12698)
                     /locus_tag="BKM31_RS28805"
                     /old_locus_tag="BKM31_28550"
     CDS             complement(12324..12698)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541673.1"
                     /locus_tag="BKM31_RS28805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_28550"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_080041120.1"
                     /transl_table=11
                     /translation="MTLSVAQIDRETDQLVDEWLTLPEVASRLDLPIGRAKQLLRDHKL
                     LGVRRGSGGPQVPAVFLDGKDVMKGLPGTLTVLQDAGYDDVEALRWLFTPDESLPGSPI
                     EAIKAGRHTEVKRRAQALAF"
     gene            complement(12729..13898)
                     /locus_tag="BKM31_RS28810"
                     /old_locus_tag="BKM31_28555"
     CDS             complement(12729..13898)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541672.1"
                     /locus_tag="BKM31_RS28810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_28555"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_329607755.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1e-43, bitscore:
                     149.1, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVNHVVVVGAGLAGVRTVEALRGRGFTGRITLIGEERHRPYDRP
                     PLSKAVLKGDADTSYVDTDLDALGVEFWAGVAAKSLRPGVVETTEGEVPYDGLVISTGA
                     DPIRLPGDGPQHVLRTIDDAHELRAVLVPGARVAIIGAGWIGAEVATAARRADCEVTVI
                     ESAATPLSTAVGTEIGGRTLPWYDGIDLRLGVMVDSVDEGGVRLVGGEFVDAHVVVTGI
                     GVRPAVEWLADADIDLHNGVVTDEHLRASLPGVVAVGDCAAWWSRRWRTRLRVEHWDTA
                     LNAPEVAAATLLGEEAVYDPVPYFWSEQFGHMLQYAGHHPAGDRLIYRGEPEDKWSAVW
                     LTADDTLAAVLAVDRPRDLVQGRRIIDAGSRLDAERLVDPQVPLRDCVV"
     regulatory      13951..14068
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(14025..14038)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     gene            14058..15278
                     /locus_tag="BKM31_RS28815"
                     /old_locus_tag="BKM31_28560"
     CDS             14058..15278
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541671.1"
                     /locus_tag="BKM31_RS28815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_28560"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_329607756.1"
                     /sec_met_domain="DAO (E-value: 9.5e-64, bitscore: 215.6,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVIVGGGVVGLSVAWRMAREGRPVTVVDPAPGKGASYAAAGMLA
                     PVSEVTYTEGPLLRLGVASLRRWPAFAAELAADAGFTGEGDATGLVTGPGAGTGSGAGA
                     APAEVRALDLRADGTLDVAFGADDMAALGELAAYMEKLDLPVERLTGRECRRLEPMLAP
                     SVRGGLLAPGDAWVDPRRVTAALLAALERLDVPVVRARATGLLYEGGRVAGVRLAPPSS
                     EPEHEHEHGRGEVPGEVRGERVVVAAGAWSSELAEVPVRPVKGQIMRLRSPQPLLRRCV
                     RGTVHGSSVYLVPRGDGELVVGATQEEMGFDTKVTAGGLYELLRDARELVPGVTELEVA
                     DVVAGLRPGTPDNLPLIGPSGTPGLAFATGHHRGGVLLAPLTTAILLGEESELAALCAP
                     GRFREIS"
     gene            15275..15475
                     /gene="thiS"
                     /locus_tag="BKM31_RS28820"
                     /old_locus_tag="BKM31_28565"
     CDS             15275..15475
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541670.1"
                     /locus_tag="BKM31_RS28820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_28565"
                     /product="sulfur carrier protein ThiS"
                     /protein_id="WP_185106778.1"
                     /transl_table=11
                     /translation="MIVVINGSTHEVADGMTVAQAVHTLTSATTGVAVAVNDEVVTRGA
                     WETTALRDRDRVEVLTAVQGG"
     gene            15516..16223
                     /locus_tag="BKM31_RS28825"
                     /old_locus_tag="BKM31_28570"
     CDS             15516..16223
                     /EC_number="2.8.1.10"
                     /GO_function="GO:1990107 - thiazole synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889484.1"
                     /locus_tag="BKM31_RS28825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_28570"
                     /product="thiazole synthase"
                     /protein_id="WP_230466537.1"
                     /transl_table=11
                     /translation="MGTGGAPSLEVLDQALVASGTELTTVAMRRLDPGARGSVLDVLRE
                     RDIKVLPNTAGCFTAGEAVLTARLAREALGTDWVKLEVIADERTLLPDPIETFDAAERL
                     VADGFVVLPYIGDDPALARRLEQAGCAAVMPLGAPIGSGLGIRNPHNIELIVEAASVPV
                     ILDAGIGTASDAALAMELGCDAVLLATAVTRAQRPDLMAAAMKAAVTAGRLARQAGRIP
                     RRRYAEASSPMTP"
     gene            16350..18344
                     /gene="pknB"
                     /locus_tag="BKM31_RS28830"
                     /old_locus_tag="BKM31_28575"
     CDS             16350..18344
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630843.1"
                     /locus_tag="BKM31_RS28830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_28575"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_080041123.1"
                     /sec_met_domain="Pkinase (E-value: 2.9e-51, bitscore:
                     173.8, seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 3.5e-05, bitscore: 23.3,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTTTADPLVGRLLDGRYRIESRIARGGMATVYLALDIRLDRTVA
                     LKVMHRSLAEDPAFVRRFIGEAKSVASLSHPNVVHVFDQGTDNDVVYLSMEYVPGRTLR
                     DILRERGRLPAREALEIMIPVLAALGAAHQAGMVHRDVKPENVLMTDDGRVKVVDFGLA
                     KAIEATNQTRTGVMIGTVGYMAPEQVITGAADVRSDVYAAGIMLFELVTGQQPYDGETP
                     MSVAYRHVHDTVPAPSSVAPEVPPLVDTLVASATAREPEHRPADATAMLVAAVDAHRML
                     PRTTIPPGTGPVMSHSQPLAAPHATMALPQGAYPGPGPGPGPGMAAPPHGAHSGAASMP
                     QPAPAHTLVQPRAEAPERRRGFRPNWFLVALAVVMVAAVGLTGWYFAQPEYVKVPDLIG
                     QNLAVAEKNLAGAGLLVRKADGQYDEKVAEGLVLSTDPAANVELEKGSTITVVLSLGPK
                     RIVVPNVEGKTANEARAEIAKAGLNVGGVKRLANPDVERDKVIRTSPQAGEKLKEGTKV
                     VIYVSAGLTMPDVGGMPKDQAAEFLTRQGFGVQVNEVDDDAEPCTVIAQAPKAKAEVDK
                     GAQVMVTVSRCQSDIWDFFRRHGEARDDEQFALVPGVIGKNVNDAKAELEALGFQVRVQ
                     RLGGGGVVQYQRPLPNSERPAGSLVYLWQ"
     gene            complement(18349..19293)
                     /gene="alc"
                     /locus_tag="BKM31_RS28835"
                     /old_locus_tag="BKM31_28580"
     CDS             complement(18349..19293)
                     /EC_number="3.5.3.4"
                     /GO_function="GO:0004037 - allantoicase activity [Evidence
                     IEA]"
                     /GO_process="GO:0000256 - allantoin catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="alc"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889482.1"
                     /locus_tag="BKM31_RS28835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_28580"
                     /product="allantoicase"
                     /protein_id="WP_080041124.1"
                     /transl_table=11
                     /translation="MSPFTRLPDLALRTLGGSVLAASDESFAEKESLIRPGRPGFRPQT
                     FGSKGQVYDGWETRRRRAPGHDWALVRLGIPGVIRGVVIDTAWFKGNYPTHASVEAACV
                     EGHPSPAEVLAAAWTEVVPLSKLTGDAEHAFDVHDEGRYTHVRLNIHPDGGVARLRVHG
                     EARPDLSVHDGLGLDLAALANGGLVTACSDEFYSAPNNVLAPGLARHQAEGWETARRRD
                     GGNDWLVIRLAGRGVVRLAEIDTTNLLFNAPAAVTLTGLDGDREIELLPRTRLQPDTPH
                     RFRLGREEPVTHVRVDIHPDGGLARVRLHGHLA"
     gene            complement(19290..20603)
                     /gene="allB"
                     /locus_tag="BKM31_RS28840"
                     /old_locus_tag="BKM31_28585"
     CDS             complement(19290..20603)
                     /EC_number="3.5.2.5"
                     /GO_function="GO:0004038 - allantoinase activity [Evidence
                     IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0050897 - cobalt ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0000256 - allantoin catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="allB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541666.1"
                     /locus_tag="BKM31_RS28840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_28585"
                     /product="allantoinase AllB"
                     /protein_id="WP_080041125.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 2.2e-22, bitscore:
                     79.2, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPFDLVVRSRRTVTPEGERAAAVAVRGERIAALYDYAAPLPAAE
                     DVDLRDLALLPGLVDTHVHVNEPGRTHWEGFDSATRAAAAGGVTTIVDMPLNSLPPAVS
                     CDALDAKLRAAEGQCHVDVAFWGGAVPGNVKDLAPLHGRGVRGFKCFMSPSGVEEFPPL
                     ADGELRLALEEVAGFGGLVIVHAEDPELLAEPEGPGYAAFLASRPGASERSAVARLVRL
                     AEETGCRVHVLHVSSAECLDVLEAAQARGVPVSAETCPHYLTLAAEQVPEGGTAYKCCP
                     PIRSESNRDLLWDGLRRGVLSCVVSDHSPSTADLKVPDFAAAWGGISSLQLGLTAVWTE
                     AARRGHGLADVVRWMSAAPAALAGIAGKGGIMAGNDADLVAFDPAADTLVDAARLHHRN
                     PVTPYHGRTLKGAVLTTWLRGRPVDGRPHGRPILEARA"
     misc_feature    complement(20919..20934)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.6"
                     /tool="antismash"
ORIGIN
        1 ccggcagctg gggctgggac gggacgccca ggatgctttc gacggtcgtc acgaacgtct
       61 ccgcctcggc gaggatctcg tcggcgtcgg cggcgctgac gcggcggacc atgcccgcct
      121 cggcggcggc ccgcttggcg gcggtggtgg agaagtagcc ggcccactcc gccaggtcgg
      181 gctcggcctc gggcaggagg tcccaggcgc tgcgcagccg gcggcggcgg ccttcggtgg
      241 ggcgggggtg ggcggccagg atcgccgctg cggctcggag tgccgccagg tgggcggcca
      301 catatcggga tgccggggtg cgagcggcgc tcgcctccgc caggcaggaa cgtgaatcgg
      361 tcaggtgtgc ccgaaccgca ggcgacagcc ggggcccggg cgtttctcta ggccgtggtg
      421 ccatcttgcg cgcctccttt ggagtcgtgg gcggcggccg gcttctgcgc cgatggagcc
      481 aacaatcgca gacgccaccg acatttccgc cgggcaggcc ggacgaggag cttcccctct
      541 ccccgtccgg ccaggacacg cccactcgtc tccgccgacg acgaggacgc gcccttcgcc
      601 cgagaacctg gccgcgggaa tcgcttgggg aagcgaacgg cccgcgacca ggctcttgtg
      661 acgttgagcc gcgagcctca ccgtcactag gtcgaacata atttcgatca cgccccgttg
      721 tcaaccgatc cacgaacaca ggttcgatga ccatgaacga aagtgccggt gaaagacgga
      781 aagccgccgc cgcgggttcg ggtgcggcga cggcgaagcg gtgctgtcag ggcggtgtca
      841 aggcgcggcc cccgccgggg ggcggctcag acgaccgaga tggccccgga cgggcagagg
      901 gtcacggccc ggcggacggc ctcttccagc tcctgtggcg gcttgtcctg aaggacgacg
      961 accgtgcctt cgtcctcgct ctggtcgaac accttcggca ccgtcagcgc gcacatgccc
     1021 gcgccgatgc acaccgtcgt atctgccttg atttccatca tgacctacca agtgacaggg
     1081 aggcggtgca ccccgtagat ggtcatgtcg gagcgcatcg gcacctcctc gggtgttacc
     1141 gccaagcgta ggccaggcag gcgccgcagc agtgccgggt aggcgatgcg catttcggcg
     1201 cgggcgagct gctggccgag gcactggtgg atgccgtggc cgaaggtcag gtgcccgccg
     1261 gcgggccggg tgacgtcgag ccgttcggcg tcggggaagc gggaggcgtc gcggttggcg
     1321 gcgggcaggt ggatggtgac ggactcgccg gccttgatgg tgacgccctc gatctcgacg
     1381 tcctccagcg cggtccggat ggggccgagg tggatgatcg tgaggtagcg cagcagctcc
     1441 tcgacgccgt tctcgacgac ggaggggtcg tcacgcatgg cggcgagctg ggcggggttc
     1501 gtgagcagcg cgtacgtgcc gaggccgagc atgttggcgg tcgtctcgtg cccggcgatg
     1561 agcaggagca ccccgacgcc ggtgagctcg tcgtcggcca gctcgccgct ctcgaggagc
     1621 ccgctgagca ggtcgtcggc cggctccttg cgcttgcgct ggatcagccc gtgcaggtac
     1681 gccgagacgc gcccgagcgc cgcgacggcg tcgtcgacct tggtctccag gttgaccagc
     1741 agcttgctgt ccgcctggaa ccggtcgcgg tcctcgtacg gcaccccgag cagctcgcag
     1801 atcaccagcg acgggatcgg cagcgcgaac tcctgcacga ggtccacggg cggccccgcg
     1861 gcctccatgg cgtcgaggca ggtctcggtg atctcctgga tgcgcggctc cagcatcttc
     1921 atccgccgca cggtgaactg gccggtgagc agtttgcggt agcgcgtgtg ctcgggggcg
     1981 tccatgcgca ggaagaagcc gggcggcacg cgcatcagct cgggccgcat ggcggcctcc
     2041 atcctggcgg agcggatggg cgggtgcacg ttgttctcgg gccggttgct gaagtgcggg
     2101 ccggccagca cggcgcgggc ggcggcgtag ccggtgacga gccagccctg gtggccgtcg
     2161 gcgtacgtca tgcggtggat cggcgcctgt tgtcgcagcg cggtgacttc gtcgggcggg
     2221 tcgagcgggc gctggcgggc ggtgggcagg gtgagttctg acatgttccg ctcccttccg
     2281 agctctccct cccagaaaac atcatcgggt gcaaagtttc aatgggtgaa aacaataagg
     2341 acgtgcagta tagttccggc atggtggaag gactccgtga gcgcaagaaa cagcgcacgc
     2401 ggcaggcgct gatcgaggcg gcgctgcggc tgttcgagga gaagggcttc gaggagacca
     2461 cgctcgcgga gatcgccgag caggccgacg tgtcgacccg cacgttcttc agctacttcg
     2521 ccagtaagga ggacgtggtc ttctacgaca ccacggcccg gctggaggcg gcgatcagcg
     2581 ccatggagag caggcggccc gacgagacgg tgaccggcgt gctgctgcgg atcatcgagg
     2641 agagcttcga gcaggcgacc tcgtaccagg acctcacgcc cgccgacgcg gcgctgcgca
     2701 tgcggctgat cctcaccgag cccgcgctgc aggcgcgggc cctgctcctg ctgttcgaca
     2761 gccagctcag gctcgccaag gggctgcgcg acgcgttccc cggcctgacg ctggccgacg
     2821 cggcggcggc cgtcggcgcg ctcatcgggg cgatcaagct gaccgtgatg gcgacgctcg
     2881 acgacgagca gacgctggag gacatcctgg ccaccgcgca ccgcgccgcc gaggtcgcga
     2941 tctccggcct gcgcaccctc gggtagggaa tgccctcccc cgtacgctct cgcgtggaaa
     3001 gcgcccggca ctttttgaga agctgtcccg cggaacctcg ggggaaggag agcggatggc
     3061 gacctcccag gggcgcggcg gccgcgtggg cctcgtgctg ctggctctgg ggccggccct
     3121 ggtggcggcc tacgcgggcg ccggttacgt ggccatcaag gcggccgtgc gggcgcaggt
     3181 caccggccct gaatgggccg gtcgcaaggc cggcgcggcc gggttcacct cgctgggcgt
     3241 cgacacctgg cggctgacct ggtggaccgc cctggtggtg gggctcgtgg cggtcctcta
     3301 cctgctcttc ggggtgctgc tgcgccgcgg gagcaggggt cgcacgctga tcctcgtggt
     3361 gtcggggctg ctgatcgtgc cgtacgcgct ggggttcggg gtcgcgctgt tcaacccgcc
     3421 cgccatgctg gcgaacctct acgacaatcc cgacttcctc gccggcctgc ccgcgtggca
     3481 gccgttcacc gcctggctgc tgctggccgc cgggctggcg caggccgtgg ggatggtgct
     3541 ggccaccacg cggatcgggc gcgcccccgc tcagcctcgg gtcggcagcc cgagctgacg
     3601 cccgccccca ggtcagtggc tcgcgccgac acccgcccgt acgactgccg cgatcaggtc
     3661 gcgggccgga cggggcgcgt ccacgaacgc gggcagatcg cttttacggg cctccagcag
     3721 gccggcgccg atgttggcga aggtcgacat cgtgtgaccc gcctggtacg cctccatccc
     3781 ggccagcccc gcccgcgcgg ccccagcggc accggaaggt agctgacggg ccgccccagc
     3841 acctccgaca gcacctcggc cagatcgtgc ccgccgaccg cgctcaggcc ctccagctcg
     3901 tacgtccggc ccgcgtgccg ccgctcgccc cccgacacga cgtcctgcca cgcctcggcc
     3961 gccacgcgca cggccacggc cgccaggtcg tcccgcgccg ccaccgacac ccgtcccgcg
     4021 ccgagcggcg ccgcgaacac cccgctctcc gccgccgccg cggcacccat gagcgccagc
     4081 ccggccggga tctcggcgta cagcccgttg cgcagcaccg tgacgtcgaa cggcgcctcc
     4141 gccagccgcg cctcggtcca ccggtgggcc agcgcgatcg tcagccgctc ccccgaggcc
     4201 gccaggctgg tgtagatcac gtgctccacg cccgcgtcgg ccgcggcccg gacgaccgcg
     4261 ccgtggcggg cgagcacgac gtcgtcctcg gcgtacccgg ccgacacgaa caccagcacc
     4321 cgcgccccct cgaacgcctc cttcagcgtc tcggggcggt cgaagtcggc gtgccgcacc
     4381 gccgtaccgt cgcccgacct gctggccccc accacctcca gcccgccggc ggcccgcagc
     4441 ccgccgagga tcgccccgcc cagtgccccg gacacgcccg taacgacaat catgagtccc
     4501 cctagtgtga gtgcgaggaa cccaggatgg gcgaggccgc gcgcccgccg taaggaggca
     4561 ctttcatgtc agtcgcgcac accgaggtaa cccctcaggt cgaggggcag gtcacggggc
     4621 cctgcgggga cgacgactgc ggcatcaggg acgtgctcga ccgcatcggc gacaagtgga
     4681 cggtgctggt gctggtggag ctgtccaagg gggtgcggcg cttcagggag ctgcaccggg
     4741 cggtgcccgg catctcgcag cgcatgctga cgttgacgac ccggcggctg tgccgggacg
     4801 ggctcgtcga gcggacggcg tacccgacga tcccgccgca ggtcgaatac cggctcacgc
     4861 ccatgggccg cagcctcgcc gaggccgtgc ggcggctggc cgactggtcg cgcgagcaca
     4921 aggacgccat ggacgacgcc cgcgcccgct gggacgccgg ccacggcctt gacagcgagg
     4981 actgagtgag ggctagcagc gggaccaggt cgcccagccg tggcgggcgc cggtgacggt
     5041 ccagccctcg ggcggcggcc cggcgtcctc ttggacgacg gcggtgcaga ttccttcggg
     5101 aggcgtcgtg ccgtggaagc gctcgatccc ggtccaccac acccggtacg acagcgggac
     5161 ccacacgttc caccgcaccc cggcctccac cgccacccgc ccgggcggcg cgggcgcggg
     5221 cagccagtcg gggccggcgg cgggcgggct gggcgccagg tgcgcgatga acgcgaggtg
     5281 gatcagcgcc agcacgccca cgaccgccgt cgcgggccgg cctgccggag tcgccgtcgc
     5341 cggccgtgcg agcagggccg cggccgtcag gcaggccagc agggccaggg ccgaaaggga
     5401 ggcggtgacc aggtcgagcg cgtcgaacgt ccgggtgagg aagatcactt cggggaagtc
     5461 gaaggcgatg aacgcgtgcc ggtgcagccg gtcccccgcg taccaggccg tcacgccgcc
     5521 ggtcacggcg agcagcccgg cggcggcgag cgcgcaccgc gccaccgcga gccgccgggc
     5581 gcgcaggagg gtgagcaggc ccgcgagggt ccaggccacg gcgacgcacg acaggtagcg
     5641 gccgtaggcg aagttgccga cccggtgctc gtctggcaag gcggccgagg aggcgtacgc
     5701 gatgcccagg gtcgccgcca gcagcgctcc cgcgaggacg cgcggcgcga gcggggccga
     5761 acggcgggcg agcagggccg ccgcgcccgc gagcccgacg ccggccaggc cccacgtgcc
     5821 ggtgacgagg taccagagct ggccggccgc gccggacaga gcccacgcct ggccgtccac
     5881 gctggtgagg cgctcgacca gcagcgccga caggtcccgg gggccgccgg ggtagagcgc
     5941 ggcccgcagc gccgcgttga gcgcgtcccc cgccaccgcg cccgcgacgg cgctcgccag
     6001 cgtcgcgatc agggcggcgc gcggcagcct gcgccagagc gcgacggcca cgagcaggca
     6061 caccgccacg atcacggtgc cgcgcaggtg cgtcgccatc gcgtacgccc ccagcccgcc
     6121 cgccacgacc ccggccacca cccgccgccg ctcagccccg cccgcgacca ggtcgtgcag
     6181 ggcggtcaac caggcgagca cgaccacggg caggatcgcg tcggccagcg cgaaccccga
     6241 gaacaccagc agcgcgggcg acagacccgc cacgaacgcg gcgaccaggg ccgcccgccg
     6301 gtccagccgc agccgccgca gcagcacgta cgccgccggg tacgcgctcg ccgccgccat
     6361 cgcccctgcc ccgacggcca gccggtacgc cagtgccggg tccgaggtga gccagaagat
     6421 ggggacgagc agcagcgcgt acccggcctg gtagaaggtg gagccggaca ggtcggcccc
     6481 ggcgccgccg gccagccatc gggcggccag gaggtagccg gtctcgtccg ggttcgccac
     6541 gggcatggtg tggtagcggt tcagccacag ccgcagcgcg acctgcgcga gccagccggc
     6601 ggcgagcagc caccacaccc gcgccccggc cgcgccgctc cgtccgcgga cgggcggagc
     6661 gggcgtgtcc accatgaaag ccgtcgtcat gagatccccc caatgtccgg gggaagctca
     6721 ccagagggcg gataaccggc ctgtcaccgt ttccggttat gcggaggtta tgcggggacg
     6781 ggcaggctcg tacgggttca ggcgcgcttg tacgcccccc tgacgtgcac cgggacgccc
     6841 ttgccgagca ggccgggcag ctccccggcc acgttcatgg gcatgcgcac gcacccgtgg
     6901 gaggccgggt agagcggcac cgacagcgcg ccgtggaagg cgatgccgcc gttgaagaag
     6961 atcgggttgt acagctcgcc caggtacgac ttgtgccagc cgctcacccg ccacgtggtg
     7021 cggtagttgc ccgtgggcgt gcgggccgag ccgcagaagc gctgctcctt gccctgccag
     7081 gtggtggtct cgcagtaggg gatgccgctg ccggaggaga tgtgggtgat gagcttcacc
     7141 tggccgcgca cgtacaggac catgatctgc ttggtgaggt tgacctcggc gcgggtcgcc
     7201 ttgccgccgg ggaccaggac cttgggggcg cgcggcgctt ccagcgcctc ccaggtgcgc
     7261 ttggcgatcg tgctggtcgg cttgatgccg ttgaccttct ggaacgccca cacggcggcc
     7321 agcgtggtgc cgccgtactg gccgtcggcc ttgccggggc ggtagccgag ctcggtcagc
     7381 cgcttctgca tccaggtgac ggccttgccc ttggcgccca gcctgagcgt cttgcgcggc
     7441 gcggtgacgg cggcttcagg cgcggcggcc gggccttgtt gggcggccgc gggagagggg
     7501 acgggtggga ggggtgtttg tgccggacgt tccatgtgct gcgtgccgca gcccgagacg
     7561 acgaccacac cggccgtcag aagagcagcc accccgggca gccgtcgaac ccgcacccgt
     7621 accacctctc ctaaagatcg gatcagggga ccatacacca ctcccccgga atgggtaata
     7681 gaggcgtcaa cctgtttaga gtgtctccat gcctgagaag ttgcccgcga acgccgtcct
     7741 cgtcgagtcc gccctgcgcg cactgggggc cgccggtgag atcgtggtcc tgccggagaa
     7801 ggcgcccacg gccgcgaccg cggcggcgca gctcggctgc gaggtgggcg cgatcgccaa
     7861 cagcctcatc ttcgacgccg acggcgcgcc gctgctcgtg ctgaccagcg gcgcgcaccg
     7921 cgtcgacgtc gagctgatcg cccgcacggc gggtgtgcgg aaggtacgcc gggcgacgcc
     7981 ggagttcgtc cggcaggcca ccgggcagcc catcggcggg gtggccccgg tcgggcatcc
     8041 ggcgcccgtg cgcaccctgg tcgacaactg gctgggcaag cacgaggtgg tgtgggccgc
     8101 gggcgggcat ccgcacacgg tgttcccgac gacgttcgac gagctcgtgc gcatcaccgg
     8161 gggcacgcct gtggacgtcg agtagtgtgc gacgggtgat cgagtttcgc ggggccggtc
     8221 cggccgagtt cgccgagcgg ctggatacgg tgatcgacat ttacacggcg gccatgaatc
     8281 cgccggagga tcagatcacc ggccgcaaga ccatcatgcg aaatcacgcg acatatcccc
     8341 attttcagtg ctatttcgcg gaattgcgtg aatcatcccc agatgcgccc gccccggaac
     8401 ctctgaccgt cggcttcgcg tacggatttc gcggcgcacc cgggcaatgg tggcacgacg
     8461 tcgtcctccg gggcctggag gaccggatgg gcacggaggc cgccaacgcc tggatggggc
     8521 acgcgttcga gctggccgag atccacgtcc accccgacta ccagggcaag ggcatcgggc
     8581 gcgccatgat ccggaccctc tgcgccggcc gccgcgaacg ctccgccgtg ctgtccaccc
     8641 acgaccagcc caccgccgcc cgccacctgt acgccagcat gggcttcacc gacctgctga
     8701 ccaggttcgt cttccccggc ggctccgagg agtacgccat cgcgggcagg ccgctgcctt
     8761 tgtaaagcca tgacctgcgg gtttgccgtc gcatgacgca gggcatgctc gatgacagca
     8821 cgtgaccggc cctttacccg ccggccgacg gcccttgccc gtcacccgcc cggtccccct
     8881 gcggacgggt ggcgggcgct cacgcttcat gggcgctcac ctcttacggg cgctcacccc
     8941 tctcgggcgc tcacccctcg cgggcgctca cctttggtga gcgtcgctca tgtggcggcc
     9001 ggcacccgct ccagccgctg gaacacctcg cgcgacgcgc tcgaccggtt gaacgtgatg
     9061 aagtggatcc ccggcgcacc ctcgtcgagc agccgctggc acagctcggc gccgtgctcg
     9121 atgccgagct gccgcaccgc cgccggatcg tccttgaccg cctcgaaccg cgccgccacg
     9181 tcgggcggga acggcgcccc cgaaagctgc tcggagcggg cgatcgtgct catctgcgtg
     9241 accggcatga tgcacgggat gatcggcgtg tcacacccct tggccgccac ccggtcacgc
     9301 agccgcaggt agtcgtcggc ctggaagaac atctgggtga tcgcgtagtc ggccccggcc
     9361 cggcacttgc gtacgaagta ttcgacgtcg gactcgacgg acggcgagcg cggatgcttg
     9421 taagggaagg cggccacgcc gacacagaag tcgcccgcct gccggatcag ccgcaccagc
     9481 tcctcggcgt acaggacgcc ctccgggtgc tggacccact cgcccatcgg gtcgcccggc
     9541 gggtcgccgc gcacggccag gatgttgcgc accccggcgt cggcgaagcg gcccacgagg
     9601 tgacgcagct cgcggaccga gtggttgacg gcggtgaagt gcgccacagg agtgagagtg
     9661 gtgtcgtggg cgatgcgctc cacgatgtcg acggtacggt cacgggtgga gccgccggcg
     9721 ccgtacgtga ccgacacgaa ggtcggacgc aacgactcca gctccctgat cgcccgccag
     9781 agctgccgcg cgccctcgtc ggtcttcggg gggaagaact cgaacgagaa cgaccggcca
     9841 ccggaggcga gcatctcgcg gacggtggga acacgatcgg gccggatgga ggatcgacca
     9901 agcgccatga gccaaggtta ccgtcacatg tgcgaaccag cgggtgagag cagccacctg
     9961 gagatcctga cctgtccccg cggccactag tctcaggggc atgaccactc acgccgccgg
    10021 catggagacc ctgcgcgcgc aggtggagcg cgccctcgcg gagttcgtcg agcggaaact
    10081 gccctcgggc ggcgaccccg agttcgcgcc gctgcgcacg gccgccgacg agctgctgtc
    10141 cggcggcaag cggctgcgcc cggcgttctg ctactggggc tggcgcggcg ccggcggcac
    10201 cgacgagccc ggcgtcttca ccgccgccgc ctccctggag ctgctccagg ccagcgcgct
    10261 cgtgcacgac gacgtgatgg ataagagcga cctgcgccgg ggcatgccgt ccgcgcaccg
    10321 ccgcttccag gccatgcacg agaagtccgg ctggcacggc tcggccgagc agttcggcga
    10381 aggcgccgcc atcctgctcg gcaacctgct cctcatctgg tccggcgaga tgtggcgcac
    10441 cagcggcctg ccccgcgaag ccctcgacgc cgcccagccc gtccacgacc acatgcgcag
    10501 cgagctcatg tgcggccagt acctcgacct gctggagcag gcccacggcg agaacacctt
    10561 cgagtccgcg ctgcgggtgg cgctgttcaa gagcggcaag tactcggtgg agcagccgct
    10621 caggctcggc ctcgccctcg ccgcccgcga gctcacgccc tggatggacg agctgtgcac
    10681 cggctacggg cggcgcgtcg ggatcgcctt ccagctccgc gacgacatcc tcggcgtctt
    10741 cggcgacccc gcccagaccg gcaaacccgc cggcgacgac ctgcgggaag gcaagcgcac
    10801 catgctcgtc gcccgcaccc tcgccgccgc ctcccccgcc gacgccgaca ccgtccgcct
    10861 cctcctgggg gatccgggcc tggacgaggc cggcgtcgcc acgctccggc ggatcatcga
    10921 gggcacgggg gccttgcagg agtgcgagga cctgatcggc gactacctga gccaggccct
    10981 ctcggccctg gagtcgtccc cggtcacccc cgaggcccgc aaggcactca ccgagctcgc
    11041 catcgccgcc acctcccgca aaacctgacc acccttcacc ggcggtgacg ggccggagtg
    11101 gcgggcacac gtgcggcgca gcacaggccc acgcaggcga ccaccgtgat gcgagcgatc
    11161 cgcagggcga gagtgacggg cgggagtggc gggcgcacgt ggcggcgcag cacaggccca
    11221 cgcaggctac cgccgcgatg cgggcgccgc gcagggcgac ggcgacgggc ggggtggcgc
    11281 ggtgccccga gcgaagcgcg ccggagcacg tagccgccac ggcaaccgcc gcgccacgtg
    11341 ccgcgtgagg cgcgccgcct gccgcgtcag gcgcaccgcg tgccgcgtca ggcgcaccgc
    11401 gtgccgcgtg ccgcgtgccg tgtgaggcgt gccgcgtgcg gcgtgaggcg cgctgcgtgc
    11461 ggcgccgctg cgtgaggcga ggaccgggcc ggcgaccgtg cgcagcgcga gggtcacgga
    11521 cgggatcgcg cagcgccaca ccccgcagcg cggagcggcg cggcggacgg cagcgcgatg
    11581 acgcacaccc gcccgccgag gggggcgcgc gtgtgagggc ggcgccggga tacgagcggc
    11641 gccttctgac gcgttcaggg cgcggcgggt cggtgggcgc ccgcggtgcg ggcgggcgcc
    11701 cgagtggtca ggcggtggcc aggcgcttgg cgaactccgc ggccgccgcc cccgggtcgt
    11761 cggcctcggt gatcgcgcgg acgaccacca cgcgccgcac ccccagcgac aggacctcgt
    11821 cgaggttggc gaggtcgatg ccgccgatgc cgaaccacgg ccgcggggtg tccagcgacg
    11881 ccgcgtgccg gagcagcggc gggccggggg ccgggcggcc gggcttggtc ggggtgggcc
    11941 agatggggcc gcagcagaag tagtcgacgc cctcctccac ggccgcggcg gatgcctcgg
    12001 cggtggagtg ggtggaccgt ccgatgacga tgtcgtcgcc gagtatctct cgcgcgaccg
    12061 tcacaggaag gtcgtcctgc cccaggtgga gcacgtcggg ccgggcggcg taggcgatgt
    12121 ccgcccggtc gttgacggcc agcagcttgc cgtgccggtc gcaggcgtcg cggaagactt
    12181 cgaggagggc gagttcttcg cgggcctcca ggcccttctc ccgcagctgg atgatgtcca
    12241 cgccgccggc cagcaccgag tcgaggaact ctgccagatc gccgcggtcg cggcggccgt
    12301 ctgtgcagag atagaggcgg gcctcagaaa gcgagggctt gggcacgccg cttgacctca
    12361 gtgtgacggc cggccttgat cgcctcgatg ggcgaccccg gcagggactc gtctggggtg
    12421 aagagccagc gcagcgcctc gacgtcgtcg tagccggcgt cctgcaacac ggtgagcgtg
    12481 cctggcaggc ccttcatcac gtcctttccg tcgaggaaca ccgcgggcac ctgcggcccg
    12541 ccgctgcccc ggcgtacgcc gaggagcttg tggtcccgga ggagttgctt ggcccgcccg
    12601 atcgggagat cgaggcgcga ggccacttcg gggagggtga gccactcgtc tacgagctgg
    12661 tcggtctccc ggtcgatctg tgcaacagaa agcgtcacga aaccacaact accacatggc
    12721 gtgcttgctc aaacaacaca atcccgtagg ggtacttgtg gatctaccag gcgttccgcg
    12781 tcgagacggg acccggcgtc gatgatacgg cgtccttgga cgagatcgcg cggccggtcc
    12841 acggcgagga cggcggcgag ggtgtcgtcg gcggtgagcc agacggccga ccatttgtcc
    12901 tcgggttcgc cgcgatagat gagccggtcg cccgcggggt ggtggccggc gtactggagc
    12961 atgtgcccga actgctcgga ccagaagtac ggcaccgggt cgtacaccgc ctcctcgccc
    13021 agcagcgtgg cggcggcgac ctcgggggcg ttgagggcgg tgtcccagtg ctcgacccgc
    13081 aggcgggtgc gccagcggcg cgaccaccag gcggcgcagt cgccgacggc gacgacgccg
    13141 ggcagcgagg cgcgcaggtg ctcgtcggtg acgacgccgt tgtgcaggtc gatgtcggcg
    13201 tcggcgagcc attcgacggc ggggcggacg ccgatgccgg tgacgacgac gtgcgcgtcg
    13261 acgaactcgc cgccgaccag ccgtacgccg ccctcgtcga cggagtcgac catgacgccg
    13321 agccgcaggt cgatgccgtc gtaccagggc agggtgcgcc cgccgatctc ggtgccgacg
    13381 gcggtcgaca gcggcgtggc ggcgctctcg atgaccgtga cctcgcagtc ggcgcggcgg
    13441 gcggcggtgg cgacctcggc gccgatccag ccggcgccga tgatcgcgac gcgggcgccg
    13501 gggacgagca cggcgcgcag ctcgtgggcg tcgtcgatgg tgcgcaggac gtgctgcggg
    13561 ccgtcgccgg gcagccggat cgggtcggcg ccggtggaga tcacgaggcc gtcgtagggg
    13621 acctcgccct cggtggtctc cacgacgccg ggacgcagcg acttggcggc gacgcccgcc
    13681 cagaactcga cgccgagcgc gtcgaggtcg gtgtcgacgt agctggtgtc ggcgtcgccc
    13741 ttcagcaccg ccttggacag cggcggacgg tcatagggcc gatggcgctc ctcgccgatc
    13801 agcgtgatcc ggccggtgaa gccgcgcccg cgcagggcct ccaccgtacg cactccggcc
    13861 aggccggctc ccaccaccac gacatggttc acgctcatga ccataacggg gggcgtgccc
    13921 gggcgtcgca ccgaggccgt aggctgttcg ggtaagacgc gcgggagtcc ggccgttcac
    13981 cgggctgaga ggaaggcttt cacgggcctt cgaccgcaag acacctgatc cggatcatgc
    14041 cggcgaaggg agcgcaggtg gatgtgatcg tgggtggcgg ggtcgtcggg ctctcggtgg
    14101 cctggcggat ggcgcgcgag gggcggcccg tcaccgtggt ggatccggct cccggcaagg
    14161 gggcctcgta cgcggcggcg gggatgctcg cgccggtcag cgaggtgacc tacaccgagg
    14221 ggccgttgct gcggctgggg gtggcctcgc tgcggcgctg gccggccttc gccgccgagc
    14281 tggccgccga cgcgggcttc accggcgagg gcgacgcgac gggcctggtc acggggccgg
    14341 gtgccgggac gggttcgggt gccggggcgg cgccggccga ggtgcgggcg ctggacctgc
    14401 gggccgacgg aaccctcgat gtcgcgttcg gggccgacga catggccgcg ctgggcgagc
    14461 tggccgcgta catggagaag ctggacctgc cggtcgagcg gctcacgggc cgtgagtgcc
    14521 gccgcctgga gcccatgctg gccccgtccg tgcgcggcgg cctgctcgcg ccgggcgacg
    14581 cgtgggtgga cccgcggcgc gtgacggcgg ccctgctggc cgcgctggag cggctggacg
    14641 tccccgtggt gcgggcgcgc gcgaccgggc tcctgtacga gggcggcagg gtcgcggggg
    14701 tacgcctcgc cccgccgtcc tcggagcccg agcacgagca tgagcacggc cggggagagg
    14761 tgcccggcga ggtgcggggt gagcgggtcg tggtggcggc cggggcgtgg agctcggagc
    14821 tggccgaggt gccggtgcgg ccggtcaagg ggcagatcat gcggttgcgc tcgccgcagc
    14881 cgctgctgcg ccggtgtgta cgcggcaccg tgcacggctc gtccgtctac ctggtccccc
    14941 ggggcgacgg cgagctcgtg gtcggggcca cgcaggagga gatgggcttc gacacgaagg
    15001 tgacggcggg cgggctctac gagctgctgc gcgacgccag ggagctggtg ccgggcgtca
    15061 ccgagctgga ggtcgccgac gtggtggcgg ggctgcgtcc gggcactccg gacaaccttc
    15121 cgctgatcgg cccgagcggg acgccggggc tggcgttcgc gacggggcat caccggggcg
    15181 gcgtcctgct ggccccgctc acgaccgcga tcctgctggg cgaggagagc gagctggcgg
    15241 cgctgtgcgc accagggaga tttcgggaaa tttcatgatt gttgtgatca acggctctac
    15301 ccacgaggtg gccgacggca tgaccgtggc ccaggccgta cacacgctga cctcggccac
    15361 caccggagtg gccgtggccg tgaacgacga ggtggtcacg cgcggcgcct gggagacgac
    15421 ggcgctgcgc gaccgtgacc gcgtggaggt gctgacggcg gtgcaaggtg gatgatctga
    15481 tcatcgccgg ggagaagttc tcctcccggc tcatcatggg caccggcggc gcgccctcgc
    15541 tggaggtgct cgaccaggcg ctggtggcgt cgggcaccga gctgaccacg gtggcgatgc
    15601 gccggctcga ccccggcgcc cgcggctccg tcctcgacgt gctgcgcgag cgcgacatca
    15661 aggtcctgcc gaatacggcg ggctgcttca ccgcgggcga ggccgtgctg acggcccggc
    15721 tggccaggga ggcgctgggc accgactggg tcaagctgga ggtcatcgcc gacgagcgga
    15781 cgctgctgcc cgacccgatc gagacgttcg acgcggccga gcggctggtg gccgacgggt
    15841 tcgtggtgct gccgtacatc ggcgacgacc cggcgctggc gcggcggctg gagcaggccg
    15901 gctgcgccgc cgtgatgccc ctgggggcgc cgatcggctc ggggctcggc atccgcaacc
    15961 cgcacaacat cgagctcatc gtggaggccg cctcggtgcc ggtcatcctc gacgcgggca
    16021 tcggcacggc cagcgacgcc gcgctggcga tggagctggg ctgcgacgcc gtcctgctgg
    16081 ccacggcggt cacccgggcg cagcggcccg acctcatggc ggcggccatg aaggcggccg
    16141 tgacggccgg gcggctggcc cgtcaggcgg gccgcatccc gcgccgccgc tacgccgagg
    16201 cgtcgtcccc gatgacccct tgacggcggc gcgccttcag ggccgatgcc gctgcgcgac
    16261 cgggcgggga cgttccgtgg agaacgtctc cgcatcggtt tcgggcgcca gggccatgcc
    16321 ggtggcaaaa cgcccgtaaa ctcggcgggg tggatacgac gactgcggac cccctggtcg
    16381 ggcggctcct cgatgggcgc taccgcatcg agagccggat cgcccggggc ggtatggcga
    16441 ccgtctacct ggcgctcgac atccggctcg accggacggt ggcgctgaag gtcatgcacc
    16501 gctcgctcgc cgaggaccct gcgttcgtca gaaggttcat cggcgaggcc aagtcggttg
    16561 ccagcctctc gcaccccaac gtggtgcacg tcttcgacca gggcaccgac aacgacgtcg
    16621 tctacctgtc gatggagtac gtcccgggcc ggaccctgcg cgacatcctg cgggagcgcg
    16681 gcaggctgcc cgcccgcgag gcgctcgaga tcatgatccc ggtgctcgcc gcgctcggcg
    16741 ccgcccacca ggccgggatg gtccaccgcg acgtcaagcc cgagaacgtc ctgatgaccg
    16801 acgacggccg ggtcaaggtc gtcgacttcg gcctggccaa ggcgatcgag gcgacgaacc
    16861 agacccgtac cggcgtgatg atcggcacgg tcggctacat ggcgccggag caggtcatca
    16921 ccggcgccgc cgacgtgcgc agcgacgtct acgccgcggg catcatgctg ttcgagctgg
    16981 tgacggggca gcagccgtac gacggggaga ccccgatgtc ggtggcctac cggcacgtcc
    17041 acgacacggt gccggcgccg tcgtcggtgg cgccggaggt gccgccgctg gtcgacacgc
    17101 tggtggcgag cgcgaccgcg cgcgagcccg agcaccggcc cgccgacgcg acggcgatgc
    17161 tggtggccgc ggtcgacgcg caccgcatgc tgccgcgcac gacgatcccg ccgggcaccg
    17221 gcccggtgat gtcgcactcg cagccgctcg ccgcgcccca cgcgacgatg gcgctgccgc
    17281 agggcgccta tcccggcccc ggccccggcc ccggacccgg catggccgcg ccgccgcacg
    17341 gcgcgcactc cggcgcggcg tcgatgccgc agccggcgcc cgcgcacacg ctggtccagc
    17401 cccgggcgga ggctccggag cggcggcgcg ggttccgccc caactggttc ctggtggcgc
    17461 tggccgtcgt gatggtcgcg gcggtcgggc tgacggggtg gtacttcgcc cagcccgagt
    17521 acgtcaaggt gcccgacctg atcggccaga acctcgccgt ggcggagaag aacctcgcgg
    17581 gcgccgggct gctggtgcgc aaggccgacg gccagtacga cgagaaggtg gccgagggcc
    17641 tggtcctgag caccgacccg gcggcgaacg tcgagctgga gaagggctcc acgatcaccg
    17701 tggtgctctc gctcggcccc aagcgcatcg tggtgcccaa cgtcgagggc aagaccgcca
    17761 acgaggcccg cgccgagatc gccaaggcgg ggctgaacgt cggcggcgtc aagcggctgg
    17821 ccaaccccga cgtcgagcgc gacaaggtga tccgcacctc gccgcaggcg ggcgagaagc
    17881 tcaaggaggg caccaaggtc gtcatatacg tcagcgccgg gctcaccatg cccgacgtgg
    17941 gcgggatgcc gaaggaccag gcggccgagt tcctgacccg tcagggcttc ggggtgcagg
    18001 tcaacgaggt cgacgacgac gccgagccgt gcacggtcat cgcgcaggcg cccaaggcca
    18061 aggccgaggt cgacaagggc gcgcaggtca tggtgacggt gtcgcgctgc cagagcgaca
    18121 tctgggactt cttccgcagg cacggcgagg cgcgcgacga cgagcagttc gccctggtgc
    18181 ccggggtgat cggcaagaac gtcaacgacg cgaaggccga gctggaggcc ctggggttcc
    18241 aggtgcgggt gcagcggctg ggcggcggcg gcgtggtgca gtaccagcgg ccgctgccca
    18301 acagcgagcg gcccgcgggc agcctcgtct acctctggca gtaggagttc aggccaggtg
    18361 tccgtggagg cggaccctgg ccaggccgcc gtccgggtgg atgtccacgc ggacgtgcgt
    18421 gaccggctcc tcgcgcccga gccggaagcg gtgcggcgtg tcgggctgca ggcgggtcct
    18481 gggcaggagc tcgatctcgc ggtccccgtc gaggcccgtc agcgtgaccg cggcgggcgc
    18541 gttgaacagc aggttcgtgg tgtcgatctc ggcgagccgg acgacgccgc gcccggcgag
    18601 ccggatgacg agccagtcgt tgccgccgtc gcgccgccgc gcggtctccc agccctccgc
    18661 ctggtgccgg gccaggccgg gcgcgagcac gttgttgggc gcggagtaga actcgtcgga
    18721 gcaggcggtg acgagcccgc cgttggcgag cgcggccagg tcgagcccga ggccgtcgtg
    18781 gacgctgagg tcgggacggg cctcgccgtg cacgcggagc cgggcgacgc ctccgtcggg
    18841 gtggatgttc agccgtacgt gggtgtagcg gccctcgtcg tggacgtcga aggcgtgctc
    18901 ggcgtcgccg gtgagcttcg acagcggcac gacctccgtc caggccgccg ccagcacctc
    18961 cgcaggcgac gggtgcccct cgacgcaggc ggcctccacg gaggcgtggg tggggtagtt
    19021 gcccttgaac caggccgtgt cgatcacgac cccgcggatc acgccgggga tgccgagccg
    19081 caccagcgcc cagtcgtgcc ccggcgcgcg ccggcgccgg gtctcccagc cgtcgtagac
    19141 ctgccccttg ctgccgaacg tctggggccg gaagccgggc ctgccgggcc tgatgaggct
    19201 ctccttctcg gcgaacgact cgtcgctggc ggccaggacc gagccgccga gcgtgcgcag
    19261 ggccaggtcg ggcagccggg tgaaaggact catgcgcggg cctccaggat cggtcgtccg
    19321 tgcggccggc cgtccaccgg acggccgcgc agccaggtgg tcaggacggc ccccttgagc
    19381 gtgcggccgt ggtagggggt gacggggttc ctgtggtgga ggcgggcggc gtccacgagg
    19441 gtgtcggcgg cggggtcgaa cgccacgagg tcggcgtcgt tcccggccat gatgccgccc
    19501 ttgccggcga tgcccgccag ggcggcgggg gcggccgaca tccagcggac cacgtccgcc
    19561 agcccgtgcc cgcggcgggc ggcctccgtc cagaccgccg tcagcccgag ctggagcgag
    19621 gagatgccgc cccaggcggc ggcgaagtcg ggcaccttga ggtcggccgt ggagggcgag
    19681 tggtcggaga cgacgcagct cagcacgccg cgccgcagcc cgtcccacag caggtcgcgg
    19741 ttggactccg agcggatcgg cgggcagcat ttgtacgcgg tgccgccctc gggcacctgc
    19801 tcggccgcca gcgtcaggta gtgggggcac gtctcggcgg agaccggcac gccgcgcgcc
    19861 tgcgccgcct ccagcacgtc gaggcattcg gcgctggaga cgtgcaggac gtgcacccgg
    19921 cagccggtct cctccgccag ccgcacgagc cgggcgacgg cgctgcgctc ggaggcgccg
    19981 ggccgcgagg ccaggaacgc ggcgtagccg ggcccctcgg gctcggccag cagctccggg
    20041 tcctccgcgt gcacgatcac cagcccgccg aacccggcga cctcctccag cgcgagccgc
    20101 agctcaccgt cggccagcgg cgggaactcc tccaccccgg acggcgacat gaagcacttg
    20161 aacccgcgca ccccgcgccc gtgcagcggc gccaggtcct tgacgttgcc ggggacggcc
    20221 ccgccccaga acgcgacgtc cacgtgacac tgcccctccg cggcccgcag cttggcgtcg
    20281 agcgcgtcgc aggagacggc gggcggcagg gagttgagcg gcatgtccac gatcgtggtg
    20341 acgccgccgg ccgccgccgc cctggtggcg gagtcgaagc cctcccagtg cgtacggccg
    20401 ggctcgttga cgtggacgtg cgtgtcgacc aggcccggca ggagcgccag gtcgcgcagg
    20461 tccacgtcct cggccgcggg caagggggcg gcgtagtcgt acagggcggc gatcctctcg
    20521 ccgcgcacgg cgacggcggc ggcgcgctcc ccctcgggcg tgacggtcct gcgcgacctg
    20581 acgacgagat cgaacggggt catccatcgc cctccagccg gcggtcggcg gcgatccggg
    20641 ccgcgaggcg ttcgagcagc ggcccggcct ccgccatgca gcgggccggg tcgggctcca
    20701 ggtcggtcag ggcgtaggcg gcctcgatgc cggcggcctt cagctcggcg tcggcgagcg
    20761 tgcggcgccc gcagacggcc accaccggca cgccggccct ggccgcggcc tgggcgacgc
    20821 cgacgggggc cttgccgcgc agcgactgct catccagcga cccctcgccg gtgatcacca
    20881 ggcgcgcccc cttgaccagc tcgccgaacc cgagcaggtc gagcaggtag tcgatgccgg
    20941 gcctgatctc ggcgtgcagg aacgccagcg ccgcgaaccc gaccccgccg gccgcgcccg
    21001 cgcccggcgc ccccgcgacc cccatggcgc gcacgacgtc gtcgtgctcg accgcgccca
    21061 tcagcccg
//
