LOCUS       NZ_CP017717            22496 bp    DNA     circular CON 03-MAR-2024
DEFINITION  [Actinomadura] parvosata subsp. kistnae strain ATCC 55076
            chromosome, complete genome.
ACCESSION   NZ_CP017717
VERSION     NZ_CP017717.1
KEYWORDS    RefSeq.
SOURCE      [Actinomadura] parvosata subsp. kistnae
  ORGANISM  [Actinomadura] parvosata subsp. kistnae
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Streptosporangiaceae; Nonomuraea.
REFERENCE   1  (bases 1 to 13047416)
  AUTHORS   Nazari,B., Forneris,C.C., Gibson,M.I., Moon,K., Schramma,K.R. and
            Setedsayamdost,M.R.
  TITLE     Nonomuraea sp. ATCC 55076 harbors the largest actinomycete
            chromosome to date and the kistamicin biosynthetic gene cluster
  JOURNAL   Medchemcomm (2017) In press
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 13047416)
  AUTHORS   Nazari,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2016) Chemistry, Princeton University, 20
            Washington Road, Princeton, NJ 08544, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 18-JUN-2015
            Assembly Method                   :: Celera Assembler v. Jun 2015
            Assembly Name                     :: SmrtPipe 1.87.139483
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 110.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/03/2024 13:15:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 12,000
            CDSs (total)                      :: 11,919
            Genes (coding)                    :: 11,783
            CDSs (with protein)               :: 11,783
            Genes (RNA)                       :: 81
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 136
            CDSs (without protein)            :: 136
            Pseudo Genes (ambiguous residues) :: 0 of 136
            Pseudo Genes (frameshifted)       :: 36 of 136
            Pseudo Genes (incomplete)         :: 98 of 136
            Pseudo Genes (internal stop)      :: 10 of 136
            Pseudo Genes (multiple problems)  :: 6 of 136
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:57:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3001810
            Orig. end                         :: 3024306
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP017717.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22496
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="13"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22496
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22496
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12496](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12496)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    1181..1195
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.18"
                     /tool="antismash"
     gene            1986..3584
                     /locus_tag="BKM31_RS13545"
                     /old_locus_tag="BKM31_13450"
     CDS             1986..3584
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024808.4"
                     /locus_tag="BKM31_RS13545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_13450"
                     /product="extracellular solute-binding protein"
                     /protein_id="WP_080038490.1"
                     /transl_table=11
                     /translation="MSDARHSRRQFLQLTGSTALLAASGGLLTACGPSSPQAGPQAGTR
                     KAVMPAYVPSSLVKPDLPATAEGVLAAYYSYPAEPVTAFTDKPGEGLGEVKVLTNMFNP
                     VPPGAGANRFWQELNTRLGATLNITMAPAADYVSKLSTVIASGDLPDILMLSATLANRS
                     QILTRLCADLSDLVSGDAVKTYPFLANIPRDSWLATAYQGGVYAIPIPRAIVGTIMFAR
                     SDLIAERGLSGEPKSYDDFLALAKGLTDPARNRWAFGSAKGVITYVGTMLGVPNTWREQ
                     GGTFTSEHEVEGRKEAIAKTAEMVKAGLFHPDAIGGKLNLRDLFGNGTIALNADGYAAW
                     DILADTYKVDVGAVVSPGPARAGQAYFAITAFKKAERDRLAKLLRICDWLSAPLGTSEY
                     MFRKFGIEGTHYTMKDGTPEPTSLGKAEVKLPLEYIADAPHVLGPRPRARVHAQRAYQE
                     RVVPTIVRNPAAALYSETAVNKNGTLAKIIDQAELDIVSGRKPVSHWDEVVRQWRAQGG
                     DQIRRDYETALAKGD"
     misc_feature    complement(1989..2004)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.93"
                     /tool="antismash"
     gene            3588..4553
                     /locus_tag="BKM31_RS13550"
                     /old_locus_tag="BKM31_13455"
     CDS             3588..4553
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020543732.1"
                     /locus_tag="BKM31_RS13550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_13455"
                     /product="ABC transporter permease subunit"
                     /protein_id="WP_080038491.1"
                     /transl_table=11
                     /translation="MALDVKSPPARPAAPPRRAAPKLSRLRRDGLLLLLGVPGLLVILL
                     FHYVPMLGNVIAFKDYQPFLGIWEAPWVGFENFRVIFNGDPAFLNALVNTLVISLVQIV
                     FVFPVPIALALLLNSLAGPRVKRLAQSILYLPHFMSWVVVVAIFQHMLGNAGLLNTFLR
                     GHDLATLPLLGNPDLFLALITSQVIWKDAGWGTIIFLAALSRVDPELYEASAMDGASKT
                     RQLWHVTLPGIRGVIVLMLILKLGDVLTVGFEQIILQQGMVGTEVSEVLDTYVYTYGVV
                     GGNWGVAAAVGLVKGLVGLVLVLGANKVAHLLGERGLYTK"
     gene            4550..5404
                     /locus_tag="BKM31_RS13555"
                     /old_locus_tag="BKM31_13460"
     CDS             4550..5404
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020543731.1"
                     /locus_tag="BKM31_RS13555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_13460"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_080038492.1"
                     /transl_table=11
                     /translation="MIVRAVKGVVVAACCALVILPFLAVLSTSLADQAQVTATGGYVLW
                     PDRPNLDAYRAILAGGVVTRALLVSIGVTVAGTLLSLTCVTLLAYSLSRPGSLLHRPIL
                     LTVLFTLLFAPGMIPMYLTIKQLGLLDSYWSLILPGLASGFQIIIMRAFFQEIPGELID
                     AARIDGAGELRILLRVVLPLSKAVIAVVGLFSAVAYWNAFFNAMLYLNDTEKWPLQLVL
                     RTYVIDNSALGVDAADLSGGFLPPPQSMQMAILVLSLIPIAIVYPFLQKHFAKGILIGA
                     VKG"
     gene            5408..7483
                     /locus_tag="BKM31_RS13560"
                     /old_locus_tag="BKM31_13465"
     CDS             5408..7483
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BKM31_RS13560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BKM31_13465"
                     /product="hypothetical protein"
                     /protein_id="WP_080038493.1"
                     /transl_table=11
                     /translation="MKINEDRRRILSALGAGGAAAMALSAAPAQAAERDVRQIAGVKDL
                     RNTPGQPGEQIHLLGYHQAEPGVTATPGRGGGDLYWDETSTEPDDDGTVFAVAGVATGR
                     WKRPVATTVDLAWYGWRGTGADDDSRRLQNAVNALPAGGTIEIGPGKVLIKKTISVKRV
                     PITFDGAGHTDSPDHGTQILLQTGTADGFLLTGVHGGGFRNLQIRGLDLKGGAMIRTER
                     AGAAKEDGNYMLAFTNARFRDGHNGLVLRACNTVRFQNCVWNTFTGDQVILLNGAADDQ
                     RADPVEFVQCGIAAGSGNKVTDNVVIDGLGGSIKFIATAILFGRHGLWMRNTTGSKALP
                     KFVYFEGGGFENGHGVPVLLEAGAQAQFANTYISADGEFDNVRVGPGFVGGVTFTGCVI
                     RGAGRNGIDVASARTTVSGCLIGNNGRMAHADFARRISAVTGNGSGGVRVTTSAPHGWE
                     SDDRVTVTGITGLDGAWTIQVVSDTAFDLKGAKPGTYTGSGQVYRHGAGINIRAQATRV
                     VVTGNAIGGFVGDGVNRQDYGIVSASPDVLISANDLNGNHAGPYALTGEQTAQTRATGN
                     KGIQQIDGWLTARIDGAVTDGPHDLSNLLYADGQRLRIVRVGRKLGAGTCQVRLDADGD
                     SAGGPAIAATTTFQSTTLTSPYVVDGTSAAKRLQVRVLGSSGAEGLVVQFGYQVIA"
     misc_feature    5447..5449
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7675..8136
                     /locus_tag="BKM31_RS13565"
                     /old_locus_tag="BKM31_13470"
     CDS             7675..8136
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012792.4"
                     /locus_tag="BKM31_RS13565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_13470"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_080038494.1"
                     /transl_table=11
                     /translation="MLITEVSPADDPLGAQLLALQHASYAVEAELIGDDRIPPLHESLD
                     DLRGQPLSWLVARIEGDRLAGAVAWEETPAEVDINRLIVHPDVLRRGIGRSLVKEVMAR
                     AGERRIVVSTGRDNVPARALYERLGFGARGEREVIPGLWITQYGFPAAL"
     gene            complement(8207..8740)
                     /locus_tag="BKM31_RS13570"
                     /old_locus_tag="BKM31_13475"
     CDS             complement(8207..8740)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024242.4"
                     /locus_tag="BKM31_RS13570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_13475"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_230466146.1"
                     /transl_table=11
                     /translation="MRPELLVVTDTGVTTAAFSAMYDFALNLIRRHSGAGVARTTARVA
                     LVDDARSSQAPYIDGRLLPRPGNAFSQQVMRRLDQNLAARYDLAALSAAFQVSTRTLLR
                     RFAEETGQSPLAYLQAARVRRARHLLETTDRTVAGISAAVGYADPGAFAALFARHTGRR
                     PRDYRAAFRRTSPG"
     gene            complement(9492..9749)
                     /locus_tag="BKM31_RS13580"
                     /old_locus_tag="BKM31_13480"
     CDS             complement(9492..9749)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BKM31_RS13580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BKM31_13480"
                     /product="hypothetical protein"
                     /protein_id="WP_155127039.1"
                     /transl_table=11
                     /translation="MPDGNPHTCRLRFHLNTTNAAATQYQLITPNGGGTQSANVSGGAI
                     TLDFTVSVDLTGTGWMYWSLKNSGGHQWVFTSCEIDEQTP"
     gene            complement(10001..10528)
                     /locus_tag="BKM31_RS13585"
                     /old_locus_tag="BKM31_13485"
     CDS             complement(10001..10528)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033537.1"
                     /locus_tag="BKM31_RS13585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_13485"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_080038498.1"
                     /sec_met_domain="PF13471 (E-value: 3.3e-10, bitscore: 39.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDRRLEWEFFLGDLDPSTLPPRTPPRLRGHAMARTAAALWTYNR
                     HGWPAAQRYLRELAPARGSARIARLPEATAVRLARREVLFCQMVTRVLAPDGQCLPRSF
                     ALAVHLNALGLPAQVIVARGRTVSVPRNAFHSWTELYGHVLNDNPDVQLGYAVLQRVRS
                     GRLGEARRPVRT"
     gene            complement(10525..10800)
                     /locus_tag="BKM31_RS13590"
                     /old_locus_tag="BKM31_13490"
     CDS             complement(10525..10800)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017239.4"
                     /locus_tag="BKM31_RS13590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_13490"
                     /product="PqqD family protein"
                     /protein_id="WP_080038499.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 2.2e-12,
                     bitscore: 46.2, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.3e-07, bitscore: 31.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPILRLAEHAVFDDTDDAGVILDNRQGVYLSLNGVATVMLRAALR
                     HETLDELIAELQGRIDAPETTLRAGYAKLVSQLGDQALLAGAEERR"
     aSDomain        complement(10549..10791)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BKM31_RS13590_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="5.30E-15"
                     /identifier="RREFam002.1"
                     /label="BKM31_RS13590"
                     /locus_tag="BKM31_RS13590"
                     /protein_end="84"
                     /protein_start="3"
                     /score="46.2"
                     /tool="antismash"
                     /translation="LRLAEHAVFDDTDDAGVILDNRQGVYLSLNGVATVMLRAALRHET
                     LDELIAELQGRIDAPETTLRAGYAKLVSQLGDQALL"
     gene            complement(10778..12496)
                     /locus_tag="BKM31_RS13595"
                     /old_locus_tag="BKM31_13495"
     CDS             complement(10778..12496)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="BKM31_RS13595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_13495"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_155127042.1"
                     /sec_met_domain="Asn_synthase (E-value: 7.2e-11, bitscore:
                     41.8, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVVLTGDYPGCYGDVRLGRPVTYECRPYGERLSRPGGVAVQWTR
                     AGASGVPAPPADGAGRHLTLSGVLHGPVTRSWSRRVIEALEGGHDTELAAVPGPLAGCL
                     VTADKVFLFRNAVAPEGLLYRREGSRVRWSTDPLDLLDGTPDDLDEQALWRCCRGDDVF
                     VYRHPQPVGPGELVVMDARSTTRRVFDRITPLELPRRTPMAEYADLAHRMLLDAVRPYA
                     GRGRIGIMLSGGLDSSAVLTALVEVGADVVAYHMHTDDPLADESAYARTVCDHLGVPFV
                     AVPTESGEGYLSRARPFPHPFVGFAYRWVEQLAERVHEDGITFLTWGADGDLCFGPYRY
                     GLHDVLFGDIAPHEKAALCRGLIASRWELSRVLRSVRRSSSLLDEYLPVGANARPTEFT
                     APAPGVPDDRYDSDYSAKEHTMDLMLWWPRGILRCSPLGDRQIKRLTARMPHAYRLLVH
                     QGRMIPKPVLRLLLSTRLPATVWRRYGRLWQDSPHKRYAIAHPHVFAGLIGTPQSQLVT
                     RGIVDRSRLAAVLAEPASLRRHSETLICAAMTELFLRDHAALTREGGTYADTATG"
     misc_feature    12558..12569
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.58"
                     /tool="antismash"
     gene            complement(12772..13641)
                     /locus_tag="BKM31_RS13600"
     CDS             complement(12772..13641)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BKM31_RS13600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_230466147.1"
                     /transl_table=11
                     /translation="MVDRLLDAIGVTRYAISVHDYGAPVDFRLALRHPERSTGIVSRNG
                     NAYEKDLTAFWEPFKTAWADPPQANTDALLGYYTREATHWQYMHDVRDTTLVNPDKAAL
                     DQAVVDRPAATPSSWPSSSTTPPTRRSTRAGRSTCAPTSRRCWPSEAATTRPSDRTGRW
                     PSPATRRTPAFNSWTPATSPWRHVARRSRPWSATFSAACRIGPAKLGRAIGFGDNPVFP
                     ALTVMPPAPLWRAYSPDRSGCRPVIGMKPARRLPAHGVFVNGPCRFVVFGGGTEQGKGP
                     GREFGPAI"
     misc_feature    complement(13622..13637)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.0"
                     /tool="antismash"
     gene            13977..14177
                     /locus_tag="BKM31_RS13605"
     CDS             13977..14177
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024736.4"
                     /locus_tag="BKM31_RS13605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transposase"
                     /protein_id="WP_080038501.1"
                     /transl_table=11
                     /translation="MPADRYPSDLTDAQWELIEPLLPEPNTGGRPEKHQRREIVNAILY
                     VVRSGYPWRYLPTDLPPWQTV"
     misc_feature    14037..14039
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(14668..14683)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.27"
                     /tool="antismash"
     misc_feature    complement(14669..14682)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.81"
                     /tool="antismash"
     misc_feature    complement(14670..14679)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.36"
                     /tool="antismash"
     misc_feature    14670..14683
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.61"
                     /tool="antismash"
     misc_feature    15154..15167
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.8"
                     /tool="antismash"
     gene            15170..15427
                     /locus_tag="BKM31_RS13615"
                     /old_locus_tag="BKM31_13510"
     CDS             15170..15427
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BKM31_RS13615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BKM31_13510"
                     /product="hypothetical protein"
                     /protein_id="WP_155127045.1"
                     /transl_table=11
                     /translation="MSLPDEVYELVKEMAEKEGTTLSGYLAALAKERADADRASRERLA
                     RLTAQDRAPDPEGYDRRKAEMRERMHAAQRAAAEKKAATA"
     gene            15424..15822
                     /locus_tag="BKM31_RS13620"
                     /old_locus_tag="BKM31_13515"
     CDS             15424..15822
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BKM31_RS13620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BKM31_13515"
                     /product="hypothetical protein"
                     /protein_id="WP_080038504.1"
                     /transl_table=11
                     /translation="MIAGYVADLTAIVRLLADGEEGADARTALEVLTEDGHTLLLPVTA
                     LAQAAIIADPDPAQLMWLFGFRSCIVEDLTRQETFRVVRQARHAPHPLEVPLHHAHTAH
                     LALDRGWPVLTGDAAGWAGYGHLEFFQV"
     gene            <15903..16211
                     /locus_tag="BKM31_RS61215"
                     /pseudo=""
     CDS             <15903..16211
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF013752.4"
                     /locus_tag="BKM31_RS61215"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="PATSQGYDAGKKIAGRKRSIITGTLGLLLAVLVATAGLPLLRQVA
                     AAQPTLVTAWADSAYRATVIEGAAALGIDLEIVSRDPAARGFAPLPRRWVAERILAG"
     gene            16211..16345
                     /locus_tag="BKM31_RS64210"
     CDS             16211..16345
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BKM31_RS64210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_268966952.1"
                     /transl_table=11
                     /translation="MLHRRLTRDYEARPGHSAAMMHIAMTGLMTRRLTGENTPTWHGT"
     gene            complement(16856..17839)
                     /locus_tag="BKM31_RS13630"
                     /old_locus_tag="BKM31_13525"
     CDS             complement(16856..17839)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066: alpha/beta hydrolase domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019474.4"
                     /locus_tag="BKM31_RS13630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_13525"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_080038505.1"
                     /transl_table=11
                     /translation="MNTKNAHERLDPELAEALKAVPMTEAGVFDLSDLEGTRAGIRAFA
                     EAIAARIPDEPSVSVEEVALARPDGSTLPIRLLRPTEAAGPLPVLLWFHGGGQVLGYAA
                     QDDPTLKRLALEVGCVVASVDYRLAPEAPAPAAAEDGLLAYRRLRRQAAALGIDEDRVA
                     LAGQSGGGGIVAATALMIRDQGEPAPLFQALSYPMLDDRNTTASSHEITDIGIWDRATN
                     ILAWNLILGDRAGSDEVPAYSAPARATDLTGLPPTFVAAAELDVFRDEDLSYATRLQAS
                     GVPVELHLYPGAYHAWDLFAPDAAVSAAYVHAWYGYLRRQFTARQP"
     gene            complement(17963..18886)
                     /locus_tag="BKM31_RS13635"
                     /old_locus_tag="BKM31_13530"
     CDS             complement(17963..18886)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020547762.1"
                     /locus_tag="BKM31_RS13635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_13530"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_080038506.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 3.3e-06, bitscore:
                     25.8, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVFVTGASGHLGSAVVPELLEAGHQVVGLARSDTSSAALTAAGA
                     EVHRGDLDDLDGLAGAAAAADGVIHLAFKHDAMFAGDFDGAVTADLRAIEALGDALAGT
                     GKPLVTTSGTVLFAFAGRKDPLTEDCTLDAGPRIDAENAVVALAERGIRSSVVRLPPTV
                     HSSLDHNGFIPTFISIARSKGVSAHVGDGANRWPAVHTLDAARLYRLALESAPAGSRLH
                     AVDDEGVTFRQIAEGIGRGLNLPVVSIPPSQAEAHFGFLSAHAQADNPSLSTLTRDLLG
                     WKPVQPGLIDDLGQGHYFDAPATIPR"
     misc_feature    complement(18936..18952)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.03"
                     /tool="antismash"
     misc_feature    complement(18990..19006)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.24"
                     /tool="antismash"
     gene            19074..19643
                     /locus_tag="BKM31_RS13640"
                     /old_locus_tag="BKM31_13535"
     CDS             19074..19643
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020547763.1"
                     /locus_tag="BKM31_RS13640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_13535"
                     /product="TetR/AcrR family transcriptional regulator;
                     helix-turn-helix transcriptional regulator"
                     /protein_id="WP_230466148.1"
                     /transl_table=11
                     /translation="MELYNDKGFEATTVAEIAARAEVTERTFYRYFADKREVLFQANAL
                     ADVLARATATAADPLAPLEVITHALTEAAPVFEERAELVRQRQAVIAANPELQERELAK
                     LASLVSILAHALRERGLDPTTAALAAEIGIAAFKVAFDRWINDPGRHTLAQHIRETLDA
                     TRRLTAPAEQAAATDDGSLPGQENVT"
     gene            19959..20435
                     /locus_tag="BKM31_RS13645"
                     /old_locus_tag="BKM31_13540"
     CDS             19959..20435
                     /NRPS_PKS="Domain: Polyketide_cyc2 (16-126). E-value:
                     1.3e-11. Score: 37.1. Matches aSDomain:
                     nrpspksdomains_BKM31_RS13645_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019928.4"
                     /locus_tag="BKM31_RS13645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_13540"
                     /product="SRPBCC domain-containing protein"
                     /protein_id="WP_222107271.1"
                     /transl_table=11
                     /translation="MRNREATKEEHTMIGDRIEREIVIAAPPERVWPLVAEPGFWAAEA
                     GDATFRGTTVTQGQSMVIKNAEHGDFPMRVEKVDPPRYLACRWVSAFPGEELRENNSTL
                     VEFTLTPEGDGTRLRVVESGFAALATSEDNRRNIVDDHTAGWKQCFEALAARAG"
     aSDomain        20007..20336
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BKM31_RS13645_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="1.30E-11"
                     /label="BKM31_RS13645_Polyketide_cyc2.1"
                     /locus_tag="BKM31_RS13645"
                     /protein_end="126"
                     /protein_start="16"
                     /score="37.1"
                     /tool="antismash"
                     /translation="RIEREIVIAAPPERVWPLVAEPGFWAAEAGDATFRGTTVTQGQSM
                     VIKNAEHGDFPMRVEKVDPPRYLACRWVSAFPGEELRENNSTLVEFTLTPEGDGTRLRV
                     VESGFA"
     gene            20445..20801
                     /locus_tag="BKM31_RS13650"
                     /old_locus_tag="BKM31_13545"
     CDS             20445..20801
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009084337.1"
                     /locus_tag="BKM31_RS13650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_13545"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_080038509.1"
                     /transl_table=11
                     /translation="MAERAADVVNDVLAALADPTRRHLLDLLSASGQASATTLADGLPV
                     SRQAVAKHLAVLDAAGLVESVKVGREVRYAVRPEALETTARWMAALAADWDRRLARIKR
                     FAEAAEQDRHHPKE"
     gene            20807..21640
                     /locus_tag="BKM31_RS13655"
                     /old_locus_tag="BKM31_13550"
     CDS             20807..21640
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017771.4"
                     /locus_tag="BKM31_RS13655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_13550"
                     /product="DUF899 family protein"
                     /protein_id="WP_222107272.1"
                     /transl_table=11
                     /translation="MHNATAMPHVVERGSFQAELDRLRIREKAHTREGDAIAAARRRLP
                     MVEVDPTLELLGPNGPVSLLDTFEGRRQLIAYSFMWNPGRPAAEQCEGCTFYTTQVGEP
                     AHLHSRDITFAVFSQGRNVASSGGDIRASYEASLRYRAFMGWEHLPWYSAQPSLDALLA
                     GRQAGLFHLICYLRDGDRVFETYWTTRRGVEALDHSYALMDLTAYGRQEPWEDSPAGWP
                     QKCTNVRTDAGSPDWPPASSWPGGRPIAQWSRLDSGRSDDLGPVGPPNQQPHPCH"
ORIGIN
        1 ctgtgccgcc tgctggcccg ctacgaacgc cccgactacc tgccgcacga cctggcgatc
       61 atcggcaccc acgccgacaa cgaggacctc gccgacggcg acgccggctt cgccgcccgc
      121 tggaacgccg tctacgccca tccccgcatc gtcgtctcca cgatggccgg ctacctggac
      181 gcggtccgcc ccctggccga ccggctgccc gtgtggcgcg gcgacggcgg cagctactgg
      241 gaggacggcg tcggcaccgg cgccaccgtg gtcgccgagc accggcgggc acagagcgcg
      301 ctgcccgcca ccgaggggct ggccgccctg gtcgcgcgga ccgaaccggc ctaccgcccc
      361 caccgggagg cgctggacgc cgcatgggag ggcgcgctgt tcggcgccga gcacacctgg
      421 acctggtcac acgcgctcgc ccacccccac ggcgagcagg tcggcgacca gctcgactgg
      481 aagcgccacc aggtgcacac cgccctgcgc accgccgtgg acgagggccg cagggcgctg
      541 agccagctcg gcgagctggt caccacccgg ggcccggcgt tgctcgtcca caacccgctg
      601 agctggacgc gggacgtgga ggtcgagtac gagtccaccg cgccgccccc gctgcccgcc
      661 gaggtgttgt ccgactgcgc cggcctgcgc cgctaccgca tgacggtggc cggcgtgccc
      721 gccttcggct accgcacgat cccgctgccc gacccggccg cgctcgcgcc gggcgaggag
      781 gacggccgcc gcgccaccgg gctcgcccat gagcaggact ggcagccggt tccgccgcgc
      841 ctggtcaccc ccctctggga ggccgagctc gatcccgcga ccggcgcgct gctcgccctc
      901 acccaccggc ccaccggacg gccgctgctc gacggccccc tcggccaggt ccgctacgtc
      961 cgcaacggcc cttccacccg cgtcgtcacc gggcacgccg gcgagccgca ccaccacccg
     1021 cccgtgcccc gcacctccct ggacggccgc cgcccgcacg ccgtccctcc ggagctggac
     1081 gtcttcccgg cggccatgcg ccccgtcggg ctgcgccgca cgtacgacgg ctggcgcgtg
     1141 cgggcggtgg gcagcgcgcc cagcctgccg cacgtcgagg tggacatcct gctcagggac
     1201 gccgacgacc gcgtggacgt gctcgtgcgc ctggagaagg agcgcgagcc cgccaaggag
     1261 tcggtctacg tcaccttccc gttcgcgcac gaggagccgc gcttctgcta cgaccgccag
     1321 cagggctgga tcgaccccgc cgccgaccac gctccgggcg cgtgccagga gtggttcacc
     1381 acccagtacg gcgtcgtcgt cagctccccg tccggcgccg tggtgtgggc ctcggccgac
     1441 gcgccgctgt tcaccgccgg ggacatcgtg cgcggcgcct ggcccgagcg cttcgccccc
     1501 gcgagcggcg cactccactc gtgggtcatg aacaactact ggcccaccaa caccccgccg
     1561 gagcaggacg gcacgctgac cctccgctac gccttccgcc ccctgcgggc cttcgacccg
     1621 gtggccgccg gccggctggg ccgcgagctc cgtgccgcgc ccatggtgtc ggaggtgacc
     1681 aggctcgaca agttcgacac cgggccccgc ccgctcgatg cccccgcggc gagcctgctc
     1741 gatctcggcc tgccggactg ggccgccgcg accgtcgccg agccacgcga ccgcaccggg
     1801 ctgctcgtcc gcctccagga cctgtcgggc cggggcggtg aggcacacct gcgccacccc
     1861 ggccggatcg tggtgtgccg cgccgacgag acggagctcg gcgagctcga cggccccgtc
     1921 cacctcggcc cctgggccgt caccaccctc aagctcctct aggacccttc cagaaaggaa
     1981 aggccatgtc tgacgcgcgt cacagcaggc gccagttcct ccagctcacc gggagcaccg
     2041 ctctgctggc cgcctcgggc ggcctgctga cggcctgcgg cccgtcctca ccccaggcgg
     2101 gcccgcaggc cgggacgcgc aaggcggtca tgcccgcgta cgtcccgtcc agcctcgtca
     2161 aacccgacct gccggccacc gccgagggcg tgctggccgc ctactactcc taccccgccg
     2221 agcccgtcac cgcgttcacc gacaagcccg gcgaagggct gggcgaggtc aaggtgctga
     2281 ccaacatgtt caacccggtg ccacccggcg cgggcgccaa ccgattctgg caggagctga
     2341 acacccggct cggcgccacg ctgaacatca ccatggcgcc cgccgccgac tacgtgagca
     2401 agctgtccac cgtcatcgcc agtggcgacc tgcccgacat cctcatgttg tcggccaccc
     2461 tggccaaccg ctcgcagatc ctcacccgcc tgtgcgccga tctcagcgac ctggtctccg
     2521 gcgacgccgt caagacctac ccgttcctcg ccaacatccc gcgcgactcg tggctggcca
     2581 ccgcctacca gggcggcgtg tacgccatcc ccatcccgcg cgccatcgtc ggcacgatca
     2641 tgttcgcccg ctccgacctc atcgccgaac ggggcctgag cggcgagccc aagagctacg
     2701 acgacttcct cgccctggcc aagggcctga ccgacccggc caggaaccgg tgggcgttcg
     2761 gcagcgccaa gggcgtcatc acctacgtcg gcaccatgct cggcgtgccg aacacgtggc
     2821 gcgagcaggg cggcacgttc acctcggaac acgaggtcga gggccgcaag gaggccatcg
     2881 ccaagaccgc cgagatggtc aaggccggcc tgttccaccc cgacgccatc ggcggcaagc
     2941 tcaacctgcg cgacctgttc ggcaacggca ccatcgcact caacgccgac ggctacgccg
     3001 cctgggacat cctggccgac acctacaagg tggacgtcgg cgccgtggtc tcgccgggcc
     3061 ctgcccgcgc gggccaggca tatttcgcca tcaccgcgtt caagaaggca gaacgcgacc
     3121 ggctggccaa gctgctgcgc atctgcgact ggctgagcgc gccgctcggc acgagcgagt
     3181 acatgttccg caagttcggc atcgagggca cccactacac gatgaaggac ggcacacccg
     3241 agccgaccag cctcggcaag gccgaggtca agctccccct ggagtacatc gccgacgccc
     3301 cccacgtgct cggcccccgg ccccgcgcac gggtgcacgc gcagcgcgcc taccaggagc
     3361 gggtcgtgcc cacgatcgtc cgcaacccgg ccgccgccct ctactccgag accgccgtca
     3421 acaagaacgg caccctcgcc aagatcatcg atcaggccga gctggacatc gtctccggcc
     3481 gcaagcccgt cagtcactgg gacgaggtcg tcagacagtg gcgcgcccag ggcggcgacc
     3541 agatccgccg cgactacgag accgcgctgg ccaagggcga ctgagcgatg gcactcgacg
     3601 tgaaatcccc gcccgcgcgc ccggccgccc cgccgcggcg cgccgcaccg aagctctccc
     3661 ggctgcgcag ggacgggctg ctgctcctgc tcggcgtgcc gggcctgctc gtgatcctgc
     3721 tgttccacta cgtgccgatg ctcggcaacg tgatcgcctt caaggactac cagcccttcc
     3781 tcggcatctg ggaggcgcca tgggtcggct tcgagaactt ccgggtgatc ttcaacggtg
     3841 acccggcgtt cctcaacgcg ctggtcaaca cgctcgtcat ctcgctcgtg cagatcgtct
     3901 tcgtcttccc cgtgccgatc gcgctggcgc tgctgctcaa ctcgctggcc gggccgcggg
     3961 tcaagcggct ggcccagtcg atcctctacc tgccgcactt catgtcgtgg gtggtcgtcg
     4021 tcgcgatctt ccagcacatg ctgggcaacg ccggcctgct gaacacgttc ctgcgcgggc
     4081 acgacctggc cacgctgccg ctcctcggca accccgacct gttcctggcc ctgatcacct
     4141 cgcaggtcat ctggaaggac gccggctggg gcacgatcat cttcctggcc gcgctctccc
     4201 gcgtcgaccc cgagctgtac gaggccagcg ccatggacgg cgcctccaag acccgccagc
     4261 tctggcacgt gacgctgccc ggcatccgcg gcgtgatcgt gctgatgctc atcctcaagc
     4321 tcggcgacgt gctcaccgtc gggttcgagc agatcatcct gcaacagggc atggtcggca
     4381 cggaggtgtc ggaagtgctg gacacctacg tctacaccta cggcgtcgtc ggcggcaact
     4441 ggggcgtggc cgccgcggtc ggcctggtca agggcctggt cgggctggtg ctcgtgctcg
     4501 gcgccaacaa ggtcgcgcac ctgctgggcg agagagggct ctacaccaaa tgatcgttcg
     4561 tgccgtcaag ggcgtggtcg tggccgcctg ctgcgccctg gtgatcctgc cgttcctcgc
     4621 cgtcctgtcc accagcctgg ccgaccaggc acaggtcacc gccaccggcg gctacgtcct
     4681 gtggcccgat cggcccaacc tcgacgccta ccgggccatc ctggccggcg gggtcgtcac
     4741 ccgggcgctg ctcgtctcca tcggcgtcac cgtggcgggc acgctgctct cactgacctg
     4801 cgtcacgctg ctggcgtact cgctgagccg gccgggctcg ctgctgcacc gcccgatcct
     4861 gctcaccgtg ctgttcacgc tgctgttcgc gcccggcatg atcccgatgt acctgacgat
     4921 caagcagctc ggcctgctgg actcctactg gtcgctcatc ctgccggggc tggccagcgg
     4981 gttccagatc atcatcatgc gcgccttctt ccaggagatc ccgggcgagc tgatcgacgc
     5041 ggcccgcatc gacggcgccg gcgagctgcg catcctgctg cgcgtcgtgc tgccgctgtc
     5101 caaggccgtc atcgccgtcg tcgggctctt cagcgcggtc gcgtactgga acgcgttctt
     5161 caacgccatg ctctacctca acgacaccga gaagtggccg ttgcagctcg tcctgcgcac
     5221 gtacgtcatc gacaacagcg cgctcggcgt cgacgcggcg gacctgtcgg gcggcttcct
     5281 gccccctccc cagtccatgc agatggcgat cctggtgctg agcctgatcc ccatcgcgat
     5341 cgtctacccg ttcctccaaa agcactttgc caagggcatc ctcatcggcg cggtgaaagg
     5401 ctgacacatg aagatcaacg aagaccgccg tcgcatcctg tcggcgttag gcgcgggcgg
     5461 cgcggccgcc atggcgctga gcgccgcacc cgcgcaggcc gccgaacgcg acgtccggca
     5521 gatcgccggg gtcaaggacc tgcgcaacac ccctggccag ccgggcgagc agatccacct
     5581 gctcggctac caccaggccg agcccggcgt gacggccacg cccggacgcg gcggcggcga
     5641 cctgtactgg gacgagacca gcaccgagcc cgacgacgac ggcaccgtct tcgccgtcgc
     5701 cggcgtggcc accggccggt ggaagcggcc cgtcgccacc accgtggacc tggcctggta
     5761 cggatggcgc ggcaccggcg ccgacgacga cagccggcgc ctccagaacg ccgtcaacgc
     5821 cctgcccgcc ggcggcacga tcgagatcgg ccccggcaag gtgctcatca agaagacgat
     5881 ctcggtcaag cgcgtgccca tcaccttcga cggcgccggc cacaccgaca gccctgacca
     5941 cggcacccag atcctgctcc agaccggaac cgccgacggc ttcctgctga ccggcgtgca
     6001 cggcggcggc ttccgcaacc tgcagatccg cggcctcgac ctgaagggcg gcgcgatgat
     6061 ccgcaccgag cgggccgggg cggccaagga ggacggcaac tacatgctgg ccttcaccaa
     6121 cgcccgcttc cgcgacggcc acaacgggct cgtgctgcgc gcctgcaaca cggtcaggtt
     6181 ccagaactgc gtctggaaca ccttcaccgg cgaccaggtc atcctgctca acggcgccgc
     6241 cgacgaccag cgcgccgacc ccgtcgagtt cgtgcagtgc ggcatcgccg cgggcagcgg
     6301 caacaaggtc accgacaacg tggtcatcga cgggctcggc ggatcgatca agttcatcgc
     6361 gaccgccatc ctgttcgggc ggcacgggct ctggatgcgc aacaccaccg gcagcaaggc
     6421 gctgccgaag ttcgtctact tcgagggcgg cggcttcgag aacggccacg gcgtgcccgt
     6481 cctgctggaa gccggggcgc aggcccagtt cgccaacacc tacatctccg ccgacggcga
     6541 gttcgacaac gtccgcgtcg ggcccggctt cgtcggcgga gtcaccttca ccggctgcgt
     6601 catccgcggc gccggccgca acggcatcga cgtcgcctcc gccaggacca ccgtgagcgg
     6661 ctgcctcatc ggcaacaacg gccggatggc ccacgccgac ttcgcccgcc ggatcagcgc
     6721 cgtgaccggc aacggctcgg gcggcgtccg cgtcaccacc tccgccccgc acggctggga
     6781 gagcgacgac cgcgtcaccg tcaccgggat caccggcctg gacggcgcct ggacgatcca
     6841 ggtggtcagc gacacggcct tcgacctgaa gggcgcgaaa cccggcacct acacgggcag
     6901 cggccaggtc taccggcacg gcgccggcat caacatccgc gcgcaggcga cccgcgtggt
     6961 cgtcaccggc aacgccatcg gcggcttcgt cggcgacggc gtcaaccggc aggactacgg
     7021 catcgtcagc gcctcacccg acgtcctcat cagcgccaac gacctcaacg gcaaccacgc
     7081 cggcccgtac gccctgaccg gcgagcagac cgcccagacc cgcgccaccg gcaacaaggg
     7141 catccagcag atcgacggct ggctgaccgc gcgcatcgac ggcgccgtca ccgacggccc
     7201 gcacgacctg tccaacctgc tgtacgccga cggccagcgg ctccgcatcg tccgcgtcgg
     7261 cagaaaactc ggcgcgggaa cctgccaggt gcggctggac gccgacggcg acagcgccgg
     7321 aggaccggcg atcgccgcca ccaccacctt ccagagcacg accctcacct cgccgtacgt
     7381 ggtggatggc acctcggccg ccaaacgcct ccaggtacgc gtcctcggca gctccggcgc
     7441 cgaggggctg gtcgtgcagt tcgggtacca ggtgatcgca tgacgtaggg aaccctcagc
     7501 cgccggcgcc tgtccgaggc gcgtcccgcg gcgcaggcgg agcaggagcc tcgaacgaag
     7561 cttccagtaa caccgggccg acgaccctca gcggttcccg gccagtcgcc ggcgctacca
     7621 gggtcgcgag actaccggcc cgcttggggg cggaggcggc gtcatactga tgcgatgctc
     7681 atcaccgaag tgtccccggc cgacgatccg cttggcgcgc agttgctcgc cctgcaacat
     7741 gcctcctacg ccgtcgaggc cgagctcatc ggcgacgacc ggattccgcc cctgcacgag
     7801 agcctggacg acctgcgcgg ccagcccctc tcgtggctgg tcgcgaggat cgagggcgac
     7861 cggctggcgg gtgcggtggc gtgggaggag acgcccgccg aggtggacat caaccgcctg
     7921 atcgtccatc ccgacgtgct gcggcgaggg atcggccgga gcctggtcaa ggaggtcatg
     7981 gccagggcgg gggagcgccg gatcgtggtg tccacggggc gggacaacgt accggctcgg
     8041 gcgctgtacg aacggctggg gttcggtgcg cgcggtgagc gcgaggtgat ccccggcctg
     8101 tggatcacgc agtacgggtt cccggcggct ctctgaagtc acggcaaaga ccctttcaag
     8161 gaaggttccg cctgggcggc aggagctgtg gccgtgacgt gacgcgtcag ccagggctgg
     8221 tgcggcggaa ggccgcgcgg taatccctgg ggcggcgccc ggtgtgcctg gcgaacagcg
     8281 cggcgaacgc gccgggatcg gcgtatccga cggcggccga gatgccggcc acggtgcggt
     8341 cagtggtctc cagaaggtgg cgggcacggc ggacccgcgc cgcctgcagg tacgccagcg
     8401 ggctctgccc ggtctcctcg gcgaagcggc gcagcagcgt acgggtgctg acctggaacg
     8461 cggccgacag cgcggcgagg tcgtagcggg cggcgaggtt ctggtcgagt cggcgcatga
     8521 cctgctggga gaaggcgttg ccgggccggg gcagcaggcg cccgtcgatg tagggggcct
     8581 gggaggagcg cgcgtcgtcg acgagcgcca cgcgcgcggt cgtacgggcc acgccggcgc
     8641 cgctgtgccg gcggatgaga ttcagcgcga agtcgtacat ggcgctgaag gccgccgtcg
     8701 tcaccccggt gtcggtgacg accaggagct cgggacgcac gtcgatgccc gggtagcggc
     8761 gggccagctc gccggcgagg agccaggctg tcgtggcgcg gcgcccgtcg agcaggccgg
     8821 cctcggcgcg tccgcgagtg cgagcccggc ccggccgccg aggcgctgcg ccgacgggag
     8881 gccgacatcg ccatcgtcca cgcctacagc ctgctgccga gcgagccgcc gccccggatg
     8941 ccggcagcac cacctcatgg acgagcccgt gctgctcgcc atgcccgccg ccctggccgc
     9001 ttgtcgcggg ctgagccagg gacagcgtcc acctggccga cttcgcgcac gaacgctggc
     9061 tgatgcccgg tgccgacacc tcctgccacg agatgacccg ccgggcctgc ggcgccgccg
     9121 gtttcatgcc gcgcccgatc gtgaccgcca acgactgctc cgtgctgagc gccctggtgg
     9181 ccgcggaggc cgggacggtg ctcatcccct cgcatggccc tgccccgcga caccgagggg
     9241 atcagcctgc acccgctggc ggaacgcgtc ggccgcacgg tggcggccct acacccgcac
     9301 cggcgacgcc cgcctgccac gagtcgggct cgtgctggag gcactccgcg acgccgccgc
     9361 ggacgtgacg ggcgcgggtg agcggtgaac gccgccgtga tcagcgcccg gcggccggcg
     9421 gatcgccgcc gtacgagccc gtcgtcggcc gcgtggcgag cggtcgatcg cgtacgaggc
     9481 cgtccgccgg ctcagggcgt ctgctcgtcg atctcgcacg aggtgaagac ccactggtgg
     9541 ccgccgctgt tcttcagcga ccagtacatc cacccggtcc cggtcaggtc gacgctgacg
     9601 gtgaagtcga gcgtgatggc gcccccggag acgttcgcgc tctgcgtgcc gccgccgttc
     9661 ggggtgatga gctggtactg cgtggcggcg gcgttggtgg tgttgaggtg gaagcgcagt
     9721 cggcaggtgt gcgggttacc gtcgggcacc cgcactgcgg gtccacggtg ccgaccggag
     9781 ttcagccgta cgccgcgccg ctctgcgcac ccgcaccgga cgggagcacc gcccagagca
     9841 gcacggccgc caggcccgcc agagccgatc ttctcgaggt gatgctcatg ggcgctccct
     9901 tgcgatcgtc gtcgggtcga gtgccgcgcc caccgatgct gctcccggag caggcgcgag
     9961 gtaactgccc gccgtaggac acttacgggt gcgtccgcct tcacgtacgg accggccggc
    10021 gcgcctcgcc gaggcggccg gaccgcaccc gttgcaacac ggcgtacccg agctgcacgt
    10081 ccgggttgtc gttgagcacg tggccgtaca actcggtcca ggagtggaag gcgttgcgag
    10141 gaacggagac ggtgcgcccc ctggccacga tgacctgggc gggcagcccg agcgcgttga
    10201 ggtggacggc cagggcgaag gagcggggca ggcactgccc gtcgggggcg agcacgcgcg
    10261 tcaccatctg gcagaacagg acctcgcggc gggccagtcg gaccgcggtg gcttcgggaa
    10321 gccgggcgat gcgggccgag ccgcgggcgg gggccagctc gcgcaggtac cgctgggccg
    10381 ccggccagcc gtggcggtta taggtccaca gggccgcggc ggtccgggcc atggcgtggc
    10441 cgcgcagccg cggcggggtg cgcggaggca gcgtggacgg gtcgaggtcg ccgaggaaga
    10501 actcccattc cagccggcgg tccttcatcg ccgttcctcc gctccggcca gcagggcttg
    10561 gtcgccgagc tgggagacca gcttggcgta cccggccctg agggtggtct cgggcgcgtc
    10621 gatccggccc tgcagctcag cgatcagctc gtcgagcgtc tcgtggcgca gggcggccct
    10681 gagcatgacc gtggcgacgc cgttcaggct caggtacacc ccctgccggt tgtcgaggat
    10741 gacgcccgcg tcgtcggtgt cgtcgaagac cgcgtgctca gccagtcgca gtatcggcat
    10801 atgtcccacc ttctctggtc agggcggcgt gatcgcgcag gaacaactcg gtcatggcgg
    10861 cgcagatcag ggtctcgctg tggcggcgca gcgaggcggg ctcggccaga accgcggcca
    10921 gccggctccg atcgacgatg cccctggtca cgagctgaga ctgcggggtg ccgatcaggc
    10981 cggcgaacac gtgggggtgg gcgatggcgt accgcttgtg cggcgagtcc tgccagagcc
    11041 gcccgtacct gcgccacacg gtggccggca ggcgggtgga cagcaggagt cgcagcacgg
    11101 gcttggggat catccgtccc tggtgcacca gcagccggta ggcgtgcggc atgcgcgcgg
    11161 tgagccgctt gatctgccgg tcgcccaggg gcgagcagcg caggatgccc cgtggccacc
    11221 acagcatgag gtccatggtg tgttccttgg ccgagtagtc gctgtcgtac ctgtcgtccg
    11281 gcaccccggg cgccggggcc gtgaactcgg tcgggcgggc gttggcgccg accggaagat
    11341 actcgtccag cagcgatgac gacctgcgca cgctcctgag cacccgcgac agctcccatc
    11401 gggaggcgat caggccgcgg cacagcgccg ccttctcgtg cggcgcgatg tcgccgaaga
    11461 gcacgtcgtg caggccgtag cggtacggcc cgaaacacag gtcgccgtcg gcgccccagg
    11521 tgaggaaggt gatgccgtcc tcgtggacgc gttcggcgag ctgctcgacc cagcggtagg
    11581 cgaagccgac gaaaggatgg gggaacggcc gagcccgcga caggtaaccc tcgcccgact
    11641 ccgtgggcac cgccacgaaa ggcacgccca ggtggtcgca gacggtacgg gcgtacgcgg
    11701 actcgtcggc gagcgggtcg tccgtgtgca tgtggtaggc gacgacgtcg gcgcccacct
    11761 cgaccagtgc ggtgaggacg gcggaggagt cgaggccgcc gctgagcatg atgccgatcc
    11821 tgccgcgccc ggcgtagggg cggaccgcgt ccagaagcat gcggtgggcc aggtcggcgt
    11881 actccgccat gggcgtgcgc cgcggcagct ccagcggggt gatgcggtcg aagacgcggc
    11941 gggtggtgct gcgggcgtcc atgacgacca gctcgccggg gcctacgggc tgcggatgcc
    12001 ggtagacgaa gacgtcgtcg ccccggcagc agcgccacag tgcctgctcg tccaggtcat
    12061 ccggcgttcc gtcgagcagg tccagcggat cggtcgacca gcgcacgcgt gagccttccc
    12121 gccggtacag cagcccttcg ggggccaccg cgttgcggaa caggaagacc ttgtccgcag
    12181 tgaccaggca gccggcgagc ggcccgggga cggcggccag ctcggtgtcg tggccgcctt
    12241 ccagcgcctc gatgacgcgc cgcgaccacg accgggtcac cggcccgtgc aggacaccgg
    12301 acagcgtgag atggcggccg gcgccgtccg ccggtggcgc cggcacgccg ctcgcgccgg
    12361 ccctggtcca ctggacggcg acgcctccgg ggcgggaaag gcgttccccg taggggcggc
    12421 actcgtacgt gacgggccgg cccagccgca cgtcgccgta acaccccgga taatctcctg
    12481 tcagcaccac agccactgcc gcgacctctc ctcttcagtt ttccggaatg cgccgagccg
    12541 tttcgatcct cttcccggaa atcggttttc cgggaagagg atcgagaagg aatcagatca
    12601 gcagtgtgcg gtgggccgga ttgtcactga gcaggatgaa gcccaggtgc gtcagctcct
    12661 caaccgcccc caggacctca actttcggct ctgtgtacgc cagcatggcg actcccttac
    12721 tgctcggata tcccgacagt catggaactg taatgtcgcc ggggagggtg atcaaatggc
    12781 cggtccgaat tcgcggcccg gtccttttcc ctgctcagtg ccgccgccga aaacgacgaa
    12841 gcggcatggc ccattcacaa aaacgccgtg agcagggagg cgtcgggcgg gtttcatccc
    12901 tattaccgga cggcagccgg acctgtccgg tgagtaagcc ctccacaacg gcgccggagg
    12961 catcaccgtc agcgccggga aaaccgggtt atcgccgaat ccgatcgccc tgccaagctt
    13021 ggcgggacca atccggcagg cggcggagaa agtcgcggac cagggccgcg atctgcgggc
    13081 cacgtgtctc cagggcgaag tggccggtgt ccaggagttg aacgcgggcg ttcttcgcgt
    13141 cgcgggtgaa ggccagcgcc ccgtccggtc cgaaggtctc gtcgtggcgg cctcagacgg
    13201 ccagcagcgg cggctggtgg gtgcgcaggt actcctgccg gcgcgggtac tacggcgggt
    13261 tggtggcgta gtggaggaag agggccagct ggatggcgtg gctgccggcc ggtcgaccac
    13321 ggcctgatcc agggccgcct tgtccgggtt gacgagcgtg gtgtcgcgca cgtcgtgcat
    13381 gtactgccaa tgggtggcct cccgggtgta gtaaccgagc agggcgtcgg tgttggcctg
    13441 cggtgggtcg gcccatgccg tcttgaacgg ctcccagaac gcggtcaggt ccttttcgta
    13501 ggcgttgccg ttccggctga cgatgccggt gctccgttca gggtggcgca gtgcgaggcg
    13561 gaagtcgacc ggtgcgccgt agtcgtgcac ggagatcgcg tacctggtga cgccgatggc
    13621 gtcgagcagt cggtccacca cgtcggcgcg ctggtcgaag gtgtactccc acgcgtcggc
    13681 gtcggggcgg agctgtgacc gaagctcggg tagccgggcg cggcgaggtg gaactcgccg
    13741 gacagcgcgg ccatcagctc ctggtaggcc gccggcgagg tggggaagcc gtgcaggagc
    13801 acgagggtgg gggcggacgg gtcgccggcc tcgcggtaga agacgtcgag tccgtcgatc
    13861 ggcacggtgc ggtggggcat gctcatgacc actttctaag tgcgtgtttg agaagatcgt
    13921 tcatgttcgg cgtggcggtg tgacgacgag cgctgaagcg tcgtcagggt aggcggatgc
    13981 ccgctgatcg ctacccttca gatctgaccg acgcgcagtg ggagctgatc gagcccttac
    14041 tgcccgagcc gaacaccggc gggcgtcccg agaagcatca gcgtagggag atcgtcaacg
    14101 ccatcttgta cgtggtgcgc tcgggctacc cgtggcggta tctgcccacc gacctgccgc
    14161 cctggcagac cgtgtagtgg tacttccagc agtggggaac aggccagcgt caccgaggcg
    14221 cctctgaccg agctgcgcat caaggcctgc cgccaggtcg gacgcgagga cgagccgggc
    14281 ggcgggcatc atcgactccc agagtttcaa aagcgccgac accgtgggcc gcgacagtcg
    14341 cggctacgac gcgggcaaga aggtcaacgg ccgcaagcgg ttcatcatca ccgacaccac
    14401 cggcctgctt gtcacagtcg ccgtcatggc cgcgagttgg caagaccacg acggcgccaa
    14461 gaccgccctg ctgtcggcct acctgaccac cccgatccgg cacgtttcgc cgaccagggc
    14521 ttctcgggac ggctcgtgga ctggccccgc gacacgctgc gcaccactct ggagattgcg
    14581 cgcaagcccg ccggccagcg cggcttcagc gtcatcgccc gcggaatagc gaatctcccg
    14641 aaatgacagg attgaaagcg tcgtatgagg aaaaaaatga taactccgtc ggcccggctg
    14701 cgaatctgtc acgttgactg gtatcgctgg tccgatgatt cgtggccagg tgaactcgtc
    14761 cgcttggagc ggtatcaccc tcaccctcct catcgggcag attcgcgcca gaccgcgcga
    14821 gcaacaagct gaccgtccga tcggctggtc caagccgggc agaaagacct tcgagcccgc
    14881 cgtcaccggg cgcaaggcca ccgatcccgc agcccggatc gggtcgctga tggtcaaccc
    14941 gggcggtccc ggggtcgagt tcgcctacgg cgctccggct tcttcagtga ggagatccag
    15001 cggcgctccg gcatcgtgtc ggcaggactg cctctccgct ggacagagca tgtcagcgca
    15061 tctcgcaggc cccgcctcgg ggtctgtgcg atggggcgga cggctcctgc ttttgcggga
    15121 cagattgttt cctaccaggt agggtgccgg tatggcacaa aagttctcca tgagcctgcc
    15181 tgacgaggtg tacgagctcg tcaaagagat ggccgaaaag gaaggcacca ccctttccgg
    15241 ctatctcgcc gccctggcca aggaacgcgc cgatgccgac cgggcctccc gcgagcggct
    15301 cgcccgcctc accgctcagg accgcgcacc cgaccccgaa ggctacgacc ggcgcaaggc
    15361 ggagatgcgc gagcgcatgc acgccgccca gcgggccgcg gcggagaaga aggccgctac
    15421 cgcatgatcg cgggctacgt ggccgacctc accgccatcg tgcggctctt ggccgacggc
    15481 gaggaaggcg ccgacgcccg gaccgctctg gaggtcttga ccgaggacgg gcacaccctg
    15541 ctcctgccgg tcaccgcgct cgcccaggcg gccatcatcg ccgacccgga ccccgcgcag
    15601 ctcatgtggc tgttcggctt ccgctcctgc atcgtcgaag acttgacccg gcaggagacc
    15661 ttccgcgtcg tgcgccaggc ccggcacgcg ccacaccccc tggaggtgcc cctgcaccat
    15721 gcccacacgg cccacctcgc gctggaccgc ggctggcccg tactcacggg agacgcggcg
    15781 ggctgggcgg gatacgggca tctggagttt ttccaggtat agggcagccc gggacgcggt
    15841 cgacgctcat ggttcggtcc cgcgggcctt agtgggcgtt tagggcgacc tccaccaacg
    15901 tccccgccac cagccagggc tacgacgccg gcaagaagat cgccggccgc aaacgcagca
    15961 tcatcaccgg caccctcggc ctcctgctcg ccgtgctggt cgccaccgcc ggcctgcccc
    16021 tgttgagaca ggtcgccgca gcccagccca ccctggtcac ggcctgggcc gacagcgcct
    16081 accgcgccac cgtcatcgag ggcgccgccg ccctcggcat cgacctcgag atcgtcagcc
    16141 gcgaccctgc cgccaggggc ttcgccccgc tgccacgtcg ctgggtggcc gagcgcatcc
    16201 tggccggctg atgctgcacc gccgcctgac ccgcgactac gaagcccgcc ccggccattc
    16261 cgcagccatg atgcacatcg ccatgaccgg cctcatgacc cgccgcctca ccggcgagaa
    16321 cacccccacc tggcacggca cctgaacccg ggaccagaca ggactaaacg cccactaagc
    16381 agcgacgtgc cggccgcccc atggacgcgc agcggccggg ccaggagcag agcgcctaac
    16441 caacgctgtt gcctgcgttc gagcccacct tggccgatct tggctggcag cccccgtgtg
    16501 ccggctggtc ccgcagcgga gcaggtgggg cgcgggcgcg gttcgcatgg gggcgagagc
    16561 ggagacggaa tcggaactgc cggtgccggg ccgcgcgggg ccggggttca ggaggcgggg
    16621 ggaggtctcg aagtagccct ggtcgaggtc gccgatgagg tcggacctgg tggcgtcacg
    16681 gttcgtgatg gccgggttcg ggtgctcgat gtcgggttgt ggggccagag cagggggccg
    16741 atgccgagga tgccgaagtg ggtaccggct tcctcggcgg gtcaccggct gtcagcacgc
    16801 ccgtgtggcg gcccgccggc cgtcaccgcg cggccgggcc gtccgaaccg ggcgctcagg
    16861 gctggcgggc cgtgaactgg cggcgcaggt atccgtacca ggcgtggacg tacgcggcac
    16921 tgaccgcggc gtcgggggcg aagaggtccc aggcgtgata agcgccgggg tacaggtgca
    16981 gttcgacggg cacgccgctg gcctggagcc gcgtcgcgta gctcaggtcc tcgtcgcgga
    17041 agacgtcgag ttcggcggcc gcgacgaagg tcggcggcag gccggtgagg tccgtcgcgc
    17101 gcgcgggcgc gctgtacgca ggcacctcgt cggagccggc gcggtccccg aggatcaggt
    17161 tccaggccag gatgttggtc gcgcggtccc agatgccgat gtcggtgatc tcgtgactgg
    17221 acgcggtggt gttgcggtca tcgagcatcg ggtagctcag cgcctggaac agcggcgcgg
    17281 gctcgccctg gtcgcggatc atgagcgcgg tggccgcgac gatacccccg ccgccgcttt
    17341 ggccggccag ggcgacgcgg tcctcgtcga tgccgagcgc ggccgcctga cggcgaagcc
    17401 ggcgataggc gagcaggccg tcctcggcgg cggccggggc gggagcctcc ggcgcgagcc
    17461 ggtagtcgac ggaggcgacg acgcagccga cctccagggc caggcgcttg agggtggggt
    17521 cgtcctgggc cgcgtacccg aggacctgcc cgccgccgtg gaaccagagc agcaccggaa
    17581 gcggcccggc tgcctcggtg ggccgcagta gccggatggg gagggtggat ccgtccgggc
    17641 gggccagggc gacctcttcg accgacacgg acggctcgtc cggtatccgg gccgcgatcg
    17701 cctcggcgaa ggcgcggatg ccggcgcgcg tgccctccag gtcgctgagg tcgaacaccc
    17761 cggcctccgt catcggcacc gccttcaggg cctcggcgag ttcggggtcg agccgctcgt
    17821 gcgcgttctt ggtgttcatg tcgttcgttt cctctcggct gcgcggcagc cggtcgtaca
    17881 ggaggatggc gggtcgttcg gaccgattcc gccgggccgt ccggacgggc gcgatgaccg
    17941 ggccgggatg gagaagaggg cctcagcgcg ggatggtcgc gggggcgtcg aagtagtggc
    18001 cctggccgag gtcgtcgatg aggccgggct ggacgggctt ccagcccagg agatcgcggg
    18061 tcagcgtgct caaggacggg ttgtcggcct gggcgtgggc gctcaggaag ccgaagtggg
    18121 cctcggcctg gctcggcggg atgctgacca cgggcaggtt cagcccgcgg ccgatgccct
    18181 cggcgatctg ccggaaggtg accccctcgt catcgacggc gtgcagccgt gaccccgccg
    18241 gcgcggattc cagcgccagc cggtacaggc gggccgcatc cagcgtgtgc acggcgggcc
    18301 accggttggc cccgtcgccg acgtgggcgg agacgccctt ggaacgggcg atggagatga
    18361 acgtcgggat gaagccgttg tggtcgagcg agctgtgcac ggtcggcggg agccggacga
    18421 cggacgagcg gatgccgcgc tcggcgaggg cgaccaccgc gttctcggcg tcgatccgcg
    18481 gtcccgcgtc gagcgtgcag tcctcggtga gggggtcctt ccgtcccgcg aaggcgaaca
    18541 gcacggttcc cgacgtggtc accaaaggct tgccggtgcc ggcgagcgcg tccccgagcg
    18601 cctcgatggc gcgcaggtcc gccgtgaccg cgccgtcgaa gtcgccggcg aacatggcgt
    18661 cgtgcttgaa ggccaggtga atgacaccgt cggccgcggc ggcggccccg gcgagaccgt
    18721 cgagatcgtc gagatcgcct cggtgcacct cggcgccggc agccgtcagc gcggcggagg
    18781 acgtgtccga gcgagccagc ccgacgacct ggtgtcccgc ttcgaggagt tcggggacga
    18841 cggcggagcc gagatgtccg gaggctccgg tgacgaagac gcgcatggtg tgtgccttcc
    18901 tgctgcgagc tcccgaccag gggcggagag ccgtgatgtc agttagtgac atcactgtag
    18961 cgcccatgtc agtctctgtc atcactttga tgtcagattc tgtcatcggt gtgtagggtc
    19021 ggtgcatgag ccgatggaaa cccgacgcgc gcggccgcct ggagaaggcg gcgatggagc
    19081 tctacaacga caagggcttc gaggccacca ccgtggcgga gatcgccgct cgggccgagg
    19141 tcaccgaacg caccttctac cggtacttcg ccgacaaacg ggaagtcctc ttccaggcca
    19201 acgccctcgc tgacgtcctc gcgcgcgcca cggccaccgc cgccgaccct ctggcgccac
    19261 tggaggtgat cacacacgca ctcacagaag ccgctccggt cttcgaggaa cgcgcagaac
    19321 tggtacggca gcgccaagcc gtcatcgccg ccaatcccga gctgcaggaa cgtgaactgg
    19381 ccaaactggc ctcactcgtc tccatcctcg cccacgcgct tcgggaacgc ggtctggatc
    19441 ccaccaccgc ggcactcgcg gccgaaatcg ggatcgccgc gttcaaggtc gccttcgacc
    19501 gctggatcaa cgaccccggc cggcataccc tcgcccagca cattcgggaa accctcgacg
    19561 ccaccaggcg cctcaccgcg cccgccgaac aggccgccgc gaccgacgac gggagcctcc
    19621 caggccagga gaacgtgaca tgaatgcggc gggcaccccg agcaagggac cctccggcgc
    19681 aggggagtgg tgcgggtgct ccaggacgca gaacgagcag gcggccttgt cggccaggcc
    19741 gggtggcagg ttggggcggc aaggctttga gcttggcgcc gacgccttcg aggacagccc
    19801 gtagcgggcc tcttgctcgg caggcaggtg ctcaacaggc atgccggggc acaacacgat
    19861 cgcggtcccg acctgcctcc cgcgtttccg tcaggcgaca tgaatgtgca accccaaggt
    19921 tgcgcgacgc tcccgcatgt gcaaccctgg agttgcacat gagaaacagg gaagcgacga
    19981 aagaggagca caccatgatc ggtgaccgca ttgaacgcga gatcgtcatc gccgccccgc
    20041 cggagcgggt ctggccgctg gtggccgagc ccgggttctg ggcggcggag gcgggcgacg
    20101 cgaccttccg cggcacgacc gtcacgcaag gccagtccat ggtgatcaag aacgccgagc
    20161 acggtgactt cccgatgcgc gtggagaagg tcgatccgcc gaggtacctg gcctgccggt
    20221 gggtgagcgc gttccccggc gaggagttgc gcgagaacaa ctccacgctc gtggagttca
    20281 ccctgacgcc cgagggcgac ggcacgcggc tgcgcgtggt ggagagcggg ttcgccgcgc
    20341 tggccacgtc cgaggacaac cgccgcaaca tcgtcgacga ccacaccgcc ggctggaagc
    20401 agtgcttcga ggcgctggcg gcccgcgccg ggtgagccgc cgtcatggct gaacgcgccg
    20461 ccgacgtcgt gaacgacgtc ctcgccgcgc tggccgaccc gacccgccgg cacctgctgg
    20521 acctgctctc cgccagcggc caggcctccg cgacgacgct ggccgacgga ctgccggtct
    20581 cccgccaggc cgtggccaag cacctcgccg tcctggacgc ggccgggctg gtcgagagcg
    20641 tgaaggtcgg ccgcgaggtc cgctacgcgg tacgcccgga ggcgctggag acgacggccc
    20701 gctggatggc cgcgctcgcc gccgactggg accgccgcct cgccaggatc aaacgcttcg
    20761 cggaggcggc cgagcaggac cggcaccatc ccaaggagtg atcatcatgc acaacgccac
    20821 cgccatgccg cacgtcgtcg agcgcggcag cttccaggcc gagctcgacc gcctgcgcat
    20881 ccgggagaag gcccacaccc gggagggcga cgccatcgcc gcggcccggc ggcgcctgcc
    20941 catggtcgag gtcgacccca ccctcgaact gctcggcccg aacgggccgg tcagcctcct
    21001 cgacaccttc gagggacgcc gccagctcat cgcctactcc ttcatgtgga accccggccg
    21061 gcccgcggcc gagcagtgcg agggctgcac gttctacacc acgcaggtcg gcgagccggc
    21121 ccacctgcac tcccgcgaca tcaccttcgc ggtcttctcc caggggcgca acgtcgcctc
    21181 cagcggggga gacatccggg cctcctacga ggcgagcctg cgctaccgcg cgttcatggg
    21241 ctgggaacac ctgccgtggt actcggcgca gccatcactc gacgcgctgc tcgccggccg
    21301 ccaggccggc ctgttccacc tgatctgcta cctgcgcgac ggcgatcgcg tcttcgagac
    21361 gtactggacg acgcggcgcg gcgtggaggc gctggaccac agttacgccc tcatggacct
    21421 gaccgcgtac ggccgccagg agccctggga ggactcgccg gccggatggc cgcagaagtg
    21481 cacgaacgtg cgcaccgacg ccggctcacc cgactggccg ccggcgtcgt cgtggccggg
    21541 cggacggccc atcgcgcagt ggtctcggct cgactccggg cgttccgacg acctcggccc
    21601 cgtgggaccc ccgaaccagc agccccatcc ctgccactag ggcggtgggg tgatcgcgga
    21661 tcccgcgcgt cgcaggtggc aggctctcac ctcgtgcccc gccgctggcc ggcaggtgga
    21721 tccacgggtg cgggccgcct gccgggtggc gggccggggc ggggctcagg tggccgtccc
    21781 gatcagccgt tgcagggcgt ggtcgcgggc caggacggcg gcgcccgtca cggtggccgt
    21841 ggtgcccagg ccgctctgac gtacctcgac cgggatgtgc aggttgtgca gcgtctcgcg
    21901 gaccgtgccg aggagcagcg gattggagcc gatgccgccg cccagcacca ccagccccgg
    21961 atccaccagg gcgacgaccg ccacgatcag ccggccgagc tgcgcggcgt gctcggcgac
    22021 cgcgcgctgg gccggcgcgt gcccctcggc ggcgcgctgg aagagctcct cggcgctgga
    22081 cggtcgcggc tgctcgctcc cgggccaggc ggcgacggct cggcgcagca gctgctcggc
    22141 gccgaggaag tgttcgaggc cgtccggggc gggctgccgg tcgggggccc aggggaacgg
    22201 caggtgggcg acctccccgg cccagccgga cgcgccgcgc agcagccgtc cgtcgatgac
    22261 gatggcggcg ccgatgcgta cgccggcctg gacgtaggcg aactgtgaga acccctgcgc
    22321 caccccgacg ccccgctcag ccagggcggc gcagttgacg ttgttctcca gcaggagcgg
    22381 gacctcgggc agggagaacg ccttcagcat ggcgcgcgct tccggccggt gggacggcgc
    22441 gccggggtcg cggtcggtca cgatcgtcgg cagcgcgatc acgatctggc gcaacg
//
