LOCUS       NZ_CP017717            21143 bp    DNA     circular CON 03-MAR-2024
DEFINITION  [Actinomadura] parvosata subsp. kistnae strain ATCC 55076
            chromosome, complete genome.
ACCESSION   NZ_CP017717
VERSION     NZ_CP017717.1
KEYWORDS    RefSeq.
SOURCE      [Actinomadura] parvosata subsp. kistnae
  ORGANISM  [Actinomadura] parvosata subsp. kistnae
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Streptosporangiaceae; Nonomuraea.
REFERENCE   1  (bases 1 to 13047416)
  AUTHORS   Nazari,B., Forneris,C.C., Gibson,M.I., Moon,K., Schramma,K.R. and
            Setedsayamdost,M.R.
  TITLE     Nonomuraea sp. ATCC 55076 harbors the largest actinomycete
            chromosome to date and the kistamicin biosynthetic gene cluster
  JOURNAL   Medchemcomm (2017) In press
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 13047416)
  AUTHORS   Nazari,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2016) Chemistry, Princeton University, 20
            Washington Road, Princeton, NJ 08544, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 18-JUN-2015
            Assembly Method                   :: Celera Assembler v. Jun 2015
            Assembly Name                     :: SmrtPipe 1.87.139483
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 110.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/03/2024 13:15:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 12,000
            CDSs (total)                      :: 11,919
            Genes (coding)                    :: 11,783
            CDSs (with protein)               :: 11,783
            Genes (RNA)                       :: 81
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 136
            CDSs (without protein)            :: 136
            Pseudo Genes (ambiguous residues) :: 0 of 136
            Pseudo Genes (frameshifted)       :: 36 of 136
            Pseudo Genes (incomplete)         :: 98 of 136
            Pseudo Genes (internal stop)      :: 10 of 136
            Pseudo Genes (multiple problems)  :: 6 of 136
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:57:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2390420
            Orig. end                         :: 2411563
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP017717.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21143
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="10"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21143
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21143
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11143](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11143)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(549..1508)
                     /locus_tag="BKM31_RS10720"
                     /old_locus_tag="BKM31_10680"
     CDS             complement(549..1508)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BKM31_RS10720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BKM31_10680"
                     /product="PD40 domain-containing protein"
                     /protein_id="WP_080038008.1"
                     /transl_table=11
                     /translation="MITNLAAALALTATLGAPPAQPAAGTRLPGTGARVVADLAGRPVR
                     LTSYSVLRPDSQRAWSPAKKAFVKADGPVTVSPGERWEATLVTRAPAAPTVRFLDRRTG
                     RKTEVELPVPEDLERGRGYLHTSWPTWSPDGRTLLLNVFEPGFEPRSEGIVLVEVPALK
                     ARFVRIENALITVGGFQWTRDSKGVVVRWGKNGRSAVRQYDLTGAVKRTWQVRGRPVGH
                     GLGTFSPSGRRFVTACTSLEKAACVWDTRTGKAVTRIKIAFSPVWGPVLGWYDERHLLA
                     PVRDGFGVVDLKGRVVETLVKADKKQRIYPWFDARAKS"
     misc_feature    complement(1494..1496)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(1502..1516)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.75"
                     /tool="antismash"
     gene            1619..2083
                     /locus_tag="BKM31_RS10725"
                     /old_locus_tag="BKM31_10685"
     CDS             1619..2083
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540158.1"
                     /locus_tag="BKM31_RS10725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_10685"
                     /product="VOC family protein"
                     /protein_id="WP_080038009.1"
                     /transl_table=11
                     /translation="MTTHPTSPNGPVRQLRLVVEAEDYEAALAFYRDVLGLPEQAAFSS
                     GDGARVAILDAGRATLEIANPAQKAMIDEVEVGRQVAPKIRVAFEVDDAAGTTERLVSA
                     GATEVAPPTVTPWESLNARLDAPAGLHITVFQELRTLEEREALDGFGKDA"
     gene            2162..4447
                     /locus_tag="BKM31_RS10730"
                     /old_locus_tag="BKM31_10690"
     CDS             2162..4447
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1134: flavodoxin"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853855.1"
                     /locus_tag="BKM31_RS10730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_10690"
                     /product="FdhF/YdeP family oxidoreductase"
                     /protein_id="WP_080038010.1"
                     /transl_table=11
                     /translation="MDKVEGQDGEHLSVGAPKTWAAGLPGVRHALSYALSQTSPRRTAL
                     TLLNLNQATGLDCPGCAWPEPGRRHVNEYCENGAKHVTDEATTRRVTREFFREHPVSEL
                     AGRSDQWLNQQGRLTEPMVKRPGADHYEPIGWDDALGLLAAELRGLDDPDRALFYTSGR
                     LGNEAAFLLQLFARAYGTNNLPDCSNMCHESSGVALIDTLGVGKGSVSLDDIHDADLVF
                     VVGQNPGTNHPRMLSALEQTKRSGGSVVAVNPLPEAGLLRFKNPQKARGIVGRGTPIAD
                     QFLQIRPGGDLALFQALNLLLLQSEDERPGTVLDHAFIERHTTGFAEFAEHVRQVEWAD
                     VLAATGLSREEIERVHARVLASEKIIVCWAMGLTQHKHGVATIKEIVNFLLLRGNVGKP
                     GAGVCPVRGHSNVQGDRTMGIWERPPRAFLDALEREFGFTPPHKHGLDTVGAIQAMLDG
                     RAQVFLGVGGNFVRATPDSEVTERAMRSCRLTAHISTKLNRSHTVCGQTALILPTLGRS
                     DRDVQAGGEQFVTVEDSMSQVHASRGRLHPASDLLLSEVAIISRLARLVLGDRPDIPWE
                     TFEADYGTVRDRISRVVPGFEDFNARVAEPGGFRLPNPVSERVFRTPSGRAVFTCNPFA
                     RLEAPPGHLILQTLRAHDQWNTIPYSGDDRYRGIRHGRRVVLVNPDDLAELGIAERSVV
                     DLVGVWHDGVERRAPAFTVVAYPTARGSAAAYYPETNVLVPLDSVADHSNTPTSKAVVI
                     RLEPAGQG"
     misc_feature    2163..2176
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.36"
                     /tool="antismash"
     misc_feature    2209..2223
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 19.97"
                     /tool="antismash"
     gene            complement(4454..5107)
                     /locus_tag="BKM31_RS10735"
                     /old_locus_tag="BKM31_10695"
     CDS             complement(4454..5107)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017592962.1"
                     /locus_tag="BKM31_RS10735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_10695"
                     /product="DNA starvation/stationary phase protection
                     protein"
                     /protein_id="WP_230466097.1"
                     /transl_table=11
                     /translation="MPAKTRSSTRTTTKKQSSSQPWLHVDGTEIQEFGTVRTWPLGLSD
                     EAREYSCERLNQILADTQILYALYKKHHWLMRGPTFYQLHLLLDKHADEQLKLVDLIAE
                     RVQTLGGIAVGDPRHVAEITVVPRPPNGAEEVPAMLSRLIEAHETILIASHDAASRAAE
                     LGDDGTNDLLVSDVIRTGELQTWFLVEHLVDTPLVETPHDGQGRAPRRTTRSGK"
     misc_feature    5200..5211
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.14"
                     /tool="antismash"
     gene            complement(5262..6410)
                     /locus_tag="BKM31_RS10740"
                     /old_locus_tag="BKM31_10700"
     CDS             complement(5262..6410)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF013646.4"
                     /locus_tag="BKM31_RS10740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_10700"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_080038012.1"
                     /transl_table=11
                     /translation="MNVLISGAGVGGPTLAYWLARHGFRVTVVERAADLRSSGNPVDVR
                     GPAVDVAARMGVLPRLHEAATGNTGLSFVDGDGRTVARMDLAAGQRAGEVELPRGALAS
                     ILYERARDHAEFVFGDSIATLTQDAGGVDVTFERGAPRRFDLVVGADGLHSVTRRLAFG
                     PGAAEVRHMGLYVATTPIGGQAGPGRDVLMHNTPGQAVAVSPTPSGDLAFFLYRAPQEP
                     GFDHRDTEQHKRLLAAAFAGVGWRAPELLERVRTAGDLYFDSVSRVRLPRWSSGRVVLL
                     GDAGSCVSLFGDGSTLAMAGAATLAGELAATPGDPEAAFQRYEQAHRRLVEPKQRGIAQ
                     AASLIVPATRAGIAARDLATRVAPLVTRLRHRLLRPPAALPS"
     misc_feature    6447..6463
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.95"
                     /tool="antismash"
     gene            6503..7141
                     /locus_tag="BKM31_RS10745"
                     /old_locus_tag="BKM31_10705"
     CDS             6503..7141
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF044515.1"
                     /locus_tag="BKM31_RS10745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_10705"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_080038013.1"
                     /transl_table=11
                     /translation="MAEAQGLRADARRNRELIVAAARELFLEQGVDVALEEVARRAGVG
                     IGTLYRRFPDRDALLHAVGEQTLTRLAGLAEAAWAEEPDAWHALRRFLRGCAELRLGEL
                     SSKLDPHLHQPLRAGDDLRELRQRSIDLLLRMTERAQADGHLRPDIGPGDLALLMTLHV
                     HTPPGLPAGEAVARVTEIVLDGLRAGPGATPLPGTALSGDDLVRHTQSG"
     gene            7188..8036
                     /locus_tag="BKM31_RS10750"
                     /old_locus_tag="BKM31_10710"
     CDS             7188..8036
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (21-265). E-value:
                     1.8e-31. Score: 101.5. Matches aSDomain:
                     nrpspksdomains_BKM31_RS10750_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017579973.1"
                     /locus_tag="BKM31_RS10750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_10710"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_080038014.1"
                     /sec_met_domain="PF00561 (E-value: 6.5e-26, bitscore: 90.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.1e-19, bitscore:
                     69.9, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPYYSAHDGTRLAYHTSGAGDPLICLPGGPMQDATYLGDLGGLAA
                     HRRLILADPRGTGDSDRPDDPATYRCDRLVDDVEALREHLGLDRVDLLGHSAGGNLAVL
                     YATRYPDRVARLLLIAPSTKAVGLEPTPQARLEAAKLRAGEPWFPEAFAALEQVQAGTA
                     TAATWEAVDPFMFGRWDDAARAFQELCDRHRNDEAAAVFGAEGAYDPEATRAALGCFAA
                     PVLVLAGELDLNTLPSAAAEYAALFPAAELVVQPGAGHSPWLDDADAFVAAVTAFLGRS
                     S"
     aSDomain        7251..7982
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BKM31_RS10750_Abhydrolase_1.1"
                     /evalue="1.80E-31"
                     /label="BKM31_RS10750_Abhydrolase_1.1"
                     /locus_tag="BKM31_RS10750"
                     /protein_end="265"
                     /protein_start="21"
                     /score="101.5"
                     /tool="antismash"
                     /translation="PLICLPGGPMQDATYLGDLGGLAAHRRLILADPRGTGDSDRPDDP
                     ATYRCDRLVDDVEALREHLGLDRVDLLGHSAGGNLAVLYATRYPDRVARLLLIAPSTKA
                     VGLEPTPQARLEAAKLRAGEPWFPEAFAALEQVQAGTATAATWEAVDPFMFGRWDDAAR
                     AFQELCDRHRNDEAAAVFGAEGAYDPEATRAALGCFAAPVLVLAGELDLNTLPSAAAEY
                     AALFPAAELVVQPGAGHSPWLD"
     CDS_motif       7458..7505
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BKM31_RS10750_0001"
                     /evalue="1.10E-04"
                     /label="NRPS-te1"
                     /locus_tag="BKM31_RS10750"
                     /protein_end="106"
                     /protein_start="90"
                     /score="14.8"
                     /tool="antismash"
                     /translation="DLLGHSAGGNLAVLYA"
     gene            complement(8029..8808)
                     /locus_tag="BKM31_RS10755"
                     /old_locus_tag="BKM31_10715"
     CDS             complement(8029..8808)
                     /NRPS_PKS="Domain: PKS_KR (19-140). E-value: 6.6e-07.
                     Score: 21.3. Matches aSDomain:
                     nrpspksdomains_BKM31_RS10755_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017586608.1"
                     /locus_tag="BKM31_RS10755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_10715"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_080038015.1"
                     /transl_table=11
                     /translation="MTPAHDTPRAPRPLALVTGVGRTVGIGAGIAQRLAADGWDVAFTF
                     WTPYDERMTWGVEAGATEAIAETLTARGAATAAIEADLSDPEAPAFVFDEAERRLGPVT
                     ALVMCHCESVDSGLLDTTVESFDRHFAVNARATWLLIREYGRRFAGAHGTGRIIALTSD
                     HTVGNLPYGASKGALDRITLAAARELAHLGVTANAVNPGPVDTGWMSDGTREELLRLTP
                     LGRLGTPRDTADLVSFLCSPQGGWINGQLLLSNGGLS"
     aSDomain        complement(8389..8751)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BKM31_RS10755_PKS_KR.1"
                     /evalue="6.60E-07"
                     /label="BKM31_RS10755_PKS_KR.1"
                     /locus_tag="BKM31_RS10755"
                     /protein_end="140"
                     /protein_start="19"
                     /score="21.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VGRTVGIGAGIAQRLAADGWDVAFTFWTPYDERMTWGVEAGATEA
                     IAETLTARGAATAAIEADLSDPEAPAFVFDEAERRLGPVTALVMCHCESVDSGLLDTTV
                     ESFDRHFAVNARATWLL"
     misc_feature    complement(8785..8801)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 19.95"
                     /tool="antismash"
     misc_feature    8842..8856
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.6"
                     /tool="antismash"
     misc_feature    8988..9003
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.58"
                     /tool="antismash"
     gene            complement(9109..9966)
                     /locus_tag="BKM31_RS10760"
                     /old_locus_tag="BKM31_10720"
     CDS             complement(9109..9966)
                     /EC_number="2.1.1.255"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0042214 - terpene metabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (92-191). E-value: 3.1e-15. Score:
                     47.1. Matches aSDomain: nrpspksdomains_BKM31_RS10760_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013153643.1"
                     /locus_tag="BKM31_RS10760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_10720"
                     /product="geranyl diphosphate 2-C-methyltransferase"
                     /protein_id="WP_080038016.1"
                     /transl_table=11
                     /translation="MTVTTNAVPVLSSLYQQSVADYWNAEENPVNLRLGEVDGLYHHHY
                     GIGDVDWSVLDGPAETREQRVVKELHRLESTQAETLVAHLGPLRPEHRVLDAGSGRGGS
                     SFLANLRTGCQVDGVSISESQVAFANQQAKERGVDDRVRFHFRNMLDTGFPTGDFQAIW
                     NNESTMYVELSLLFAEHSRLLRRGGRYVCITGCYNDAYGLPSRAISQINAHYICDIHSR
                     STYFKELAAHRLVPVSVVDLTAATIPYWELRARTHLATGIEDAFLEAYKSGSFQYLLIA
                     ADRV"
     aSDomain        complement(9394..9690)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BKM31_RS10760_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="3.10E-15"
                     /label="BKM31_RS10760_oMT.1"
                     /locus_tag="BKM31_RS10760"
                     /protein_end="191"
                     /protein_start="92"
                     /score="47.1"
                     /tool="antismash"
                     /translation="RVLDAGSGRGGSSFLANLRTGCQVDGVSISESQVAFANQQAKERG
                     VDDRVRFHFRNMLDTGFPTGDFQAIWNNESTMYVELSLLFAEHSRLLRRGGRYV"
     gene            complement(10001..11143)
                     /locus_tag="BKM31_RS10765"
                     /old_locus_tag="BKM31_10725"
     CDS             complement(10001..11143)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF041167.1"
                     /locus_tag="BKM31_RS10765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_10725"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_222107197.1"
                     /sec_met_domain="T1TS (E-value: 7.1e-53, bitscore: 180.0,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPFDIPAGPTGLGSYTLSLPSALRPYRRPFEENDGHEPPSPSGSL
                     RGPVLTPLPYGERSWGDGTFPPLYCPATDRVDDALGAEVDRRLVAWAERIGLHEGRMAE
                     FASTGFGRLAMLTHSDSDDPDLLLISAQMNAAWWAADDYYADETDLGATPTELPPRLAL
                     VMSAMDPPPDAGGYTEQLEEAIRNDPVLVSLRSATSHAARHATSAQVMRLCNITSQMYV
                     SWDAYAAWRYLETPPPVWRYLAARQHDSFYTSMTLIDIVGGYELPPHLFAERRFHTALM
                     QAGTASVLVNDLHSAAKEAADELPDSNVVLLIAAEEGCSTEEAVERTVRLHNAFVRGFE
                     QSQRELSALPSPELKRFLRGAQAWMAGGLEWHGSTTRYQS"
     gene            complement(11177..12571)
                     /locus_tag="BKM31_RS10770"
                     /old_locus_tag="BKM31_10730"
     CDS             complement(11177..12571)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017601572.1"
                     /locus_tag="BKM31_RS10770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_10730"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_080038017.1"
                     /transl_table=11
                     /translation="MPTDPTETRLSLDTRAARNLATTTKTRPQMQAISSRWLLRMLPWV
                     DVRGGTYRVNRRLTHRPGRGRVGVVPGGAGDARIVPGTLTEIPALRGFGDDGVLAAIAG
                     EFTARELRPGDVVAEEGDPVTGAWVIAHGRVERVSTGRYGNPQFLGVIADGDQFGDEVL
                     TDDEARWPCTFRATTPCTALFAPRDGLRRVADRSAALREHLAGYLDKLSRPANRRGEAA
                     VHLSAGHTGEPVIDGTFVDYDLHPREYELSVAQTILRVHTRVADLFNDPMNQIEQQLRL
                     TIHELRERQESELLNHPEFGLLHNTDYDQRIYTWSGPPTPDDLDELISMRRKTRLLLAH
                     PKAIAAFFRECNKRGLVAGSTEVNGHEVPAWRGIPIFPCGKIPISEHRTTSILALRTGE
                     DDQGVVGLYQTGIPEEYEPGLNVRFMGINAQAVMSYLVSAYFSVAVLVPDAIGILEDVD
                     VAAPRS"
     misc_feature    complement(12605..12618)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 18.28"
                     /tool="antismash"
     gene            12718..13518
                     /locus_tag="BKM31_RS10775"
                     /old_locus_tag="BKM31_10735"
     CDS             12718..13518
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-161). E-value: 1.4e-08. Score:
                     26.8. Matches aSDomain:
                     nrpspksdomains_BKM31_RS10775_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017575002.1"
                     /locus_tag="BKM31_RS10775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_10735"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_080038018.1"
                     /sec_met_domain="adh_short (E-value: 3.3e-31, bitscore:
                     108.1, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDLYDRVAIVTGADSGIGKATAVALAEQGFDVGITYHSDRDGAE
                     ETARLVREPGQAAAIRQHDLTDPERAAAVVDELAGELGGLGVLVNNAGTGSHEPLLEMG
                     YERWRQILAVDLDGAFLCAQRAARRMVGTGRGGRIVNVTSVHEEYPKMGSGPYCAAKGG
                     LRMLSRVLALELADHGITVNTVAPGEIATPMTGQEDLPPQRGSRPGNPIPRPGDAREVA
                     AVVAFLAGPTASYVTGATVFVDGGMTLMGPQGASALGSGDWREL"
     aSDomain        12739..13200
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BKM31_RS10775_PKS_KR.1"
                     /evalue="1.40E-08"
                     /label="BKM31_RS10775_PKS_KR.1"
                     /locus_tag="BKM31_RS10775"
                     /protein_end="161"
                     /protein_start="7"
                     /score="26.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VAIVTGADSGIGKATAVALAEQGFDVGITYHSDRDGAEETARLVR
                     EPGQAAAIRQHDLTDPERAAAVVDELAGELGGLGVLVNNAGTGSHEPLLEMGYERWRQI
                     LAVDLDGAFLCAQRAARRMVGTGRGGRIVNVTSVHEEYPKMGSGPYCAAK"
     gene            complement(13559..14326)
                     /locus_tag="BKM31_RS10780"
                     /old_locus_tag="BKM31_10740"
     CDS             complement(13559..14326)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066: alpha/beta hydrolase domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF042769.2"
                     /locus_tag="BKM31_RS10780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_10740"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_080038019.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 3e-08, bitscore:
                     32.8, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEHPLWPATGEATITAFPVEGDGPAPAVVVCPGGAYQHLADHEG
                     APVARWLNALGVAAFVLRYRIAPHRHPLPLLDAARAVRWVRHHAADLGVDPGRVGVLGF
                     SAGGHLAGLLATEKGPVPAEGPHDAVDEADHRPDLAVLCYPVTALTGPAAHRGSSDNLL
                     GADAPDSLRAELSLASRVTADTPPMFLWHTADDEAVPVENTLMLSQALARHGVAQEVHV
                     YPSGRHGLGLADEDPVVADWTHRCAAFLRGRGS"
     gene            complement(14429..15025)
                     /locus_tag="BKM31_RS10785"
                     /old_locus_tag="BKM31_10745"
     CDS             complement(14429..15025)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019633285.1"
                     /locus_tag="BKM31_RS10785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_10745"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_080038020.1"
                     /transl_table=11
                     /translation="MPTGVHLRDPREQLFTAAEEVLRQGGPDALTSRAVTAQAGCAKGV
                     LHRHFESFDAFLAEFVLDRIDLMRAQGDVLKDSAGTGTVVDNLTDALIKLFDPVAVSIV
                     ALVTFHNQVRARLREARPVGGLPVMTEIGMILSDYLTAERELGRIAPGADIGRLAPTLV
                     GTAHLMFAGTDGLPIWPEDVRDAVASVLGNALTAG"
     gene            complement(15104..16309)
                     /locus_tag="BKM31_RS10790"
                     /old_locus_tag="BKM31_10750"
     CDS             complement(15104..16309)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="BKM31_RS10790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_10750"
                     /product="MFS transporter"
                     /protein_id="WP_222107198.1"
                     /transl_table=11
                     /translation="MPVLERTERLPRTVWWLVLARAINRLGAFSLGFLTVLITTDFGVG
                     AVAAGAISAAFGLATIPSRLLGGVLADRFGRRRTIVAGLAGCALAQAGIALSSSVAMVA
                     VFAVLLGLVFELYEPPSQAMIADAVRPAQQARAFSLFNTALAVGGMGAGLIAAGLGRWD
                     LRWLFVADAVSCVLCAIVVRLVLPADHLPHHAETRPLPAHSGSVWRDRGLLLLLLSGTL
                     SAVIFMQAGMAMPLALARRGLEAADAGLLSAVAAVTMVACQPLVRWTAALSHHAAMAYG
                     YLLLAAGLAGYAVADGLAGHLAATVVWSAGDVLMFGRSYALVVDLAPEDARGRYLSVFG
                     ISWGFATVLAPLCGTQLLDRAGPAGLWGTLALTCLLLAVAQLAVIRPLLRRSLIARAAA
                     AL"
     gene            16371..16946
                     /locus_tag="BKM31_RS10795"
                     /old_locus_tag="BKM31_10755"
     CDS             16371..16946
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF023134.4"
                     /locus_tag="BKM31_RS10795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_10755"
                     /product="CGNR zinc finger domain-containing protein"
                     /protein_id="WP_230466098.1"
                     /transl_table=11
                     /translation="MTSQVLFDSHVAILLDTAVSLVNVLTDGGDRGKPYAAPKGDALPG
                     AIRAVLPGGVPVSPEEALYLAGTTLKVRRVFEAMDEGREDDAAAVVNALVISTGARPQL
                     DRAPGEPWQVHFHGADDSLAVGWSAGIASALTLAIGSDLGGRLGVCQARQCDRVYVDAS
                     RNGVRQFCSRSCQSRTKAAAFRARHAAR"
     gene            17174..18703
                     /locus_tag="BKM31_RS10800"
                     /old_locus_tag="BKM31_10760"
     CDS             17174..18703
                     /NRPS_PKS="Domain: AMP-binding (13-414). E-value: 1.3e-92.
                     Score: 302.5. Matches aSDomain:
                     nrpspksdomains_BKM31_RS10800_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540201.1"
                     /locus_tag="BKM31_RS10800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_10760"
                     /product="AMP-binding protein"
                     /protein_id="WP_080038022.1"
                     /sec_met_domain="AMP-binding (E-value: 2.6e-98, bitscore:
                     328.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSYEPLTPTSFLERSATVFGPRLAVVDGELELTYAELWQRVQRL
                     AGALATAGVRPGDRVAVLALNGHLLLESTFGVPAAGAVMVPLNIRLSAGELAYIIGHAE
                     VTLLLHDDALTGLARQAAEGTEVRLVSATACETLLAVAEPLLVRVEDELAPLSINYTSG
                     TTGRPKGVVYHHRGAYLQALAMALHTRLDAASSYLWTLPMFHCHGWCFPWAVTLAGARH
                     VCLPRMEPDEAWRLIRAHRVTHLCGAPTVLTSLLAHDDAPARASDPRLLACVGGAPPSP
                     ALLGRALRAGIDVIHLYGLTETYGPVAICQPQPEWSDLPVAESAALTARQGVGNVIAQR
                     LRVVGDDGRDVPADAATVGEIAVRGNDVMLGYHRDPAATDKAAPDGWFRTGDLGVLHPD
                     GYVRIVDRAKDVIISGGENIASVEVENVLVEHPGVREAAVVARPDPHWGEVPVAYVSLA
                     AGARATEAELIEHVRARLAHFKAPKAITFCELPKTSTGKIQKNVLRQRAAG"
     aSDomain        17213..18415
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BKM31_RS10800_AMP-binding.1"
                     /evalue="1.30E-92"
                     /label="BKM31_RS10800_AMP-binding.1"
                     /locus_tag="BKM31_RS10800"
                     /protein_end="414"
                     /protein_start="13"
                     /score="302.5"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ERSATVFGPRLAVVDGELELTYAELWQRVQRLAGALATAGVRPGD
                     RVAVLALNGHLLLESTFGVPAAGAVMVPLNIRLSAGELAYIIGHAEVTLLLHDDALTGL
                     ARQAAEGTEVRLVSATACETLLAVAEPLLVRVEDELAPLSINYTSGTTGRPKGVVYHHR
                     GAYLQALAMALHTRLDAASSYLWTLPMFHCHGWCFPWAVTLAGARHVCLPRMEPDEAWR
                     LIRAHRVTHLCGAPTVLTSLLAHDDAPARASDPRLLACVGGAPPSPALLGRALRAGIDV
                     IHLYGLTETYGPVAICQPQPEWSDLPVAESAALTARQGVGNVIAQRLRVVGDDGRDVPA
                     DAATVGEIAVRGNDVMLGYHRDPAATDKAAPDGWFRTGDLGVLHPDGYVRIVDRAKDVI
                     IS"
     CDS_motif       17648..17698
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BKM31_RS10800_0001"
                     /evalue="1.20E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="BKM31_RS10800"
                     /protein_end="175"
                     /protein_start="158"
                     /score="21.0"
                     /tool="antismash"
                     /translation="NYTSGTTGRPKGVVYHH"
     CDS_motif       18242..18316
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BKM31_RS10800_0002"
                     /evalue="3.20E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="BKM31_RS10800"
                     /protein_end="381"
                     /protein_start="356"
                     /score="16.3"
                     /tool="antismash"
                     /translation="TVGEIAVRGNDVMLGYHRDPAATDK"
     gene            18761..20149
                     /locus_tag="BKM31_RS10805"
                     /old_locus_tag="BKM31_10765"
     CDS             18761..20149
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019633499.1"
                     /locus_tag="BKM31_RS10805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_10765"
                     /product="amino acid permease"
                     /protein_id="WP_080038023.1"
                     /transl_table=11
                     /translation="MVSSRSVFRRKPVAQIATEHEGELSRSLGLWQLTAIGVGGIIGAG
                     IFALAGAVANESAGPAVLVSFLIAGIASAAAALSYAEFAGLIPKAGSAYTYGYAVLGEI
                     VGWFIGWDLLLEYTAIVAVVAIGISGYFGFLVQQLGLTLPAWSLGAPGTGPGHVVDLFA
                     AVLCLLIAALLNLGIRAAARFETFVVAIKVAVVLLVVVVGFFHINTANYTPFFPFGVGG
                     AITGAATVFFAVFGYDAMSTAAEESRDAQRHMPKAIIYSLLISMVLYVLACLVLTGMQN
                     YRDIDPESGFSSAFAAVGLSGLASVIAVGAIVGILTVMFTFMLGVTRVWFSMSRDGLLP
                     AWFARLHPVRRVPTRVTWIVGVASALIAGFLPIKEAAELTNIGILLAFVVVCVAVIVLR
                     YRQPDLPRTFRTPWMPVVPAVGVLFSVWLITFLSPVTWLRFAVWFLIGLVVYFAYSKRH
                     SVLE"
     misc_feature    complement(20160..20172)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.13"
                     /tool="antismash"
     gene            20237..21121
                     /gene="sigJ"
                     /locus_tag="BKM31_RS10810"
                     /old_locus_tag="BKM31_10770"
     CDS             20237..21121
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="sigJ"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017567921.1"
                     /locus_tag="BKM31_RS10810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_10770"
                     /product="RNA polymerase sigma factor SigJ"
                     /protein_id="WP_080038024.1"
                     /transl_table=11
                     /translation="MNDREFLADRFEAHRGHLKAVAYRMLGSLTEAEDAVQEAWLRLSR
                     SEPDDVRNLGGWLTTVVGRVCLDMLRARTSRREEPLEARMPDPVVSPATGPDPEQAALL
                     ADSVGLALLVVLESLAPAERLAFVLHDMFAVPFEEIAPLVGRSPATARQLASRARRRVR
                     GAAPVPDPDLARQREIVEAFLAAAHRGDFAGLVSVLDPEVVLRADAGALSGGLREVRGA
                     DNVAGQALAFRRHAPSTAHAALVNGLAGVVNTVNGEPSAVMSFTIAGGRIVEIDILADP
                     ARLARLDLAVLGD"
ORIGIN
        1 ctggtcacgg ccgcgcaccg ggacaaggtg gcctcctacc tggacctcgg cgtggaggag
       61 ggcgccaagc tggtcgtgga cggccgccgg agcacgctcg tcagcggcga gcaggcggac
      121 caggcggccg ggttctggct cggcccgacc gtgctcgacc acgtgccggt cgggtcgcgg
      181 gtgcacaccg aggagatctt cggcccggtg ttgtcgatcg tgcgggtccg ctcttatgag
      241 gagggcctgg aggtgatcaa cggcggcgcg tacggcaacg gcaccgccgt gttcaccaac
      301 gacggcggcg cggcccggcg cttccagaac gaggtcgagg tcggcatggt gggcatcaac
      361 gtgccgatcc cggtgccgat ggcgttctac agcttcggcg gctggaagtc ctcgctgttc
      421 ggcgacacgc acgtgcacgg caccgagggc gtgcacttct acacccgcgg caaggtcgtc
      481 acctcccgct ggctcgaccc ctcccacggc ggcgtgaacc tgggcttccc cacgaacggg
      541 tagccccgtc agctcttggc gcgggcgtcg aaccaggggt agatgcgctg cttcttgtcg
      601 gccttcacca gcgtctcgac gacccggccc ttgaggtcga cgacgccgaa gccgtcgcgg
      661 accggcgcga gcaggtgccg ctcgtcgtac cagccgagca cgggccccca gacggggctg
      721 aaggcgatct tgatccgcgt gacggcctta ccggtgcggg tgtcccagac gcacgcggcc
      781 ttctccagcg aggtgcacgc cgtcacgaag cggcggcccg acggggagaa cgtgccgagg
      841 ccgtggccga cgggccggcc gcgtacctgc caggtgcgct tgacggcgcc ggtgaggtcg
      901 tactggcgga cggcggacct gccgttcttg ccccagcgca ccacgacgcc cttgctgtcg
      961 cgggtccact ggaagccgcc gaccgtgatc agcgcgttct cgatgcggac gaagcgggcc
     1021 ttcagcgcgg gcacctcgac cagcacgatg ccttccgagc gcggctcgaa gcccggctcg
     1081 aagacgttga ggagcagggt ccgcccatca ggggaccagg tgggccagga cgtgtgcagg
     1141 tagccgcgcc cgcgctcgag gtcctccggc acgggcagct ccacctcggt cttcctgccg
     1201 gtccgccggt cgaggaagcg cacggtgggc gcggctgggg cgcgggtgac gagcgtggcc
     1261 tcccagcgct cgccggggga gaccgtgacc gggccgtccg ccttgacgaa cgccttcttg
     1321 gccgggctcc acgcccgctg cgagtcgggc ctgagcaccg agtaggaggt gagccgcacc
     1381 ggccgccccg ccaggtcggc tacgacgcgc gcgccggtgc ccggcagcct cgtgccggcg
     1441 gccggctggg cgggcggggc gccgagcgtg gcggtcaggg cgagcgcggc cgctaagttc
     1501 gtgatcatga tgtcctcccg gaaacggatc cgaagatcat agccgcgggg gatgaagcgg
     1561 cgggcccgcc cggttgcacc ggaggaacgc gaccagaaac gtgaggagag accggcccat
     1621 gaccacgcac cccacctccc ccaacggccc cgtccgccag ctcaggctgg tcgtcgaggc
     1681 ggaggactac gaggccgcgc tggccttcta ccgcgacgtg ctgggcctgc cggagcaggc
     1741 cgcgttctcc agcggcgacg gcgcgcgggt ggcgatcctc gacgcgggcc gcgccaccct
     1801 ggagatcgcc aacccggcgc agaaggcgat gatcgacgag gtcgaggtgg ggcggcaggt
     1861 ggcgcccaag atccgggtgg cgttcgaggt ggacgacgcg gcgggcacca ccgagcggct
     1921 ggtctcggcg ggcgcgacgg aggtggcgcc gcccaccgtg acgccgtggg agtcgctcaa
     1981 cgcccgcctc gacgcgcccg ccgggctgca catcacggtc ttccaggagc tgcgcaccct
     2041 ggaggagcgc gaggcgctcg acgggttcgg caaggacgcg tagccccggt cggatccggt
     2101 ccgcgggaaa agtagagttt ttgaggggtc gtttcagcat cgagcagcga agacgtgaga
     2161 catggacaag gtcgaaggtc aggacggtga gcacctgtcg gtcggggcgc ccaagacgtg
     2221 ggcggccggg ctgcccggcg tgcggcacgc gttgtcgtac gcgttgtcgc agacgtcgcc
     2281 ccgccgcacc gcgctgacgc tgctcaacct caaccaggcc accggcctcg actgccccgg
     2341 ctgcgcctgg ccggagccgg ggcgccggca cgtcaacgag tactgcgaga acggcgccaa
     2401 gcacgtcacc gacgaggcca ccacccgccg cgtcacccgc gagttcttcc gcgagcaccc
     2461 ggtctccgag ctggccgggc gctccgacca gtggctcaac cagcagggca ggctcaccga
     2521 gcccatggtc aagcggcccg gcgccgacca ctacgagccc atcggctggg acgacgcgct
     2581 cggcctgctc gccgccgagc tgcgcggcct cgacgacccc gaccgcgcgc tgttctacac
     2641 ctcgggccgg ctcggcaacg aggccgcgtt cctgctgcag ctcttcgccc gcgcgtacgg
     2701 caccaacaac ctgcccgact gctccaacat gtgccacgag tccagcggcg tcgccctgat
     2761 cgacaccctc ggcgtcggca agggcagcgt cagcctcgac gacatccacg acgccgacct
     2821 ggtgttcgtc gtcggccaga accccggcac caaccatccc cgcatgctgt cggcgctgga
     2881 gcagaccaag cgctcgggcg gcagcgtcgt cgcggtcaac ccgctgcctg aggccgggct
     2941 gctgcgcttc aagaacccgc agaaggcgcg cggcatcgtc gggcgcggca cgccgatcgc
     3001 cgaccagttc ctgcagatcc gccccggcgg cgacctcgcc ctgttccagg cgctcaacct
     3061 gctgctgctc cagtccgagg acgagcgccc cggcaccgtg ctcgaccacg ccttcatcga
     3121 gcggcacacc accggcttcg ccgagttcgc cgagcacgtc cgccaggtgg agtgggcgga
     3181 tgtcctggcc gccaccggcc tgtcgcggga ggagatcgag cgcgtccacg cccgcgtcct
     3241 ggccagcgag aagatcatcg tgtgctgggc gatggggctg acccagcaca agcacggcgt
     3301 ggccaccatc aaggagatcg tcaacttcct gctgctgcgc ggcaacgtcg gcaagccggg
     3361 cgccggcgtc tgcccggtgc gcgggcacag caacgtgcag ggcgaccgca cgatgggcat
     3421 ctgggagcgg cccccgaggg ccttcctcga cgcgctggag cgcgagttcg gcttcacccc
     3481 gccgcacaag cacggcctcg acaccgtggg cgccatccag gccatgctcg acggccgggc
     3541 ccaggtcttc ctcggcgtcg gcggcaactt cgtgcgcgcc acccccgaca gcgaggtcac
     3601 cgagcgcgcc atgcgctcgt gccggctgac cgcgcacatc tccacgaagc tgaaccgctc
     3661 ccacaccgtc tgcggccaga ccgcgctgat cctgccgacg ctcggccgca gcgaccgcga
     3721 cgtccaggcg ggcggcgagc agttcgtgac cgtcgaagac tcgatgagcc aggtccacgc
     3781 ctcgcggggc cgcctccacc ccgcctccga cctgctgctc agcgaggtgg ccatcatcag
     3841 ccggctggcc cggctcgtgc tcggcgaccg gcccgacatc ccctgggaga cgttcgaggc
     3901 cgactacggc accgtccgcg accgcatctc ccgcgtcgtg cccggcttcg aggacttcaa
     3961 cgcccgcgtg gccgagcccg gcggcttccg cctgcccaac ccggtcagcg agcgcgtctt
     4021 ccgcaccccg agcggccggg ccgtcttcac gtgcaacccg ttcgcgcggc tggaggcccc
     4081 gcccggccac ctgatcctgc agacgctgcg cgcccacgac cagtggaaca cgatcccgta
     4141 ctccggcgac gaccgctacc ggggcatccg gcacggccgc cgggtcgtcc tcgtcaaccc
     4201 cgacgacctg gccgagctgg gcatcgccga gcgcagcgtg gtggacctgg tcggcgtctg
     4261 gcacgacggc gtggagcggc gcgcccccgc gttcacggtg gtggcctacc cgaccgcgcg
     4321 cggctcggcc gcggcctact acccggagac gaacgtgctg gtgccgctgg acagcgtggc
     4381 cgaccacagc aacacgccca cctcgaaggc cgtggtcatc cggctggagc ccgccgggca
     4441 gggctgatgc cggctacttg ccggaacggg tggtgcggcg cggcgcccgg ccctgcccgt
     4501 cgtgcggcgt ctccacgagc ggcgtgtcca ccaggtgctc gaccaggaac caggtctgca
     4561 gctcgccggt cctgatcacg tcggacacca gcaggtcgtt ggtgccgtcg tcgcccagct
     4621 ccgccgccct ggacgcggcg tcgtgcgagg cgatgaggat cgtctcgtgc gcctcgatca
     4681 gccgcgacaa catcgccggc acctcctcgg cgccgttcgg gggccgcggc accaccgtaa
     4741 tctccgcgac gtgccggggg tcgccgaccg cgatgccgcc cagcgtctgc acccgctcgg
     4801 cgatcaggtc caccagcttg agctgctcgt cggcgtgctt gtccagcagc aggtgcagct
     4861 ggtagaacgt cgggccgcgc atcagccagt ggtgcttctt gtacagcgcg tagaggatct
     4921 gcgtgtcggc caggatctgg ttcagccgct cgcaggagta ctcgcgggcc tcgtccgaca
     4981 ggcccagcgg ccacgtcctg acggtgccga actcctggat ctcggtgccg tcgacgtgca
     5041 gccacggctg gctgctcgac tgcttcttcg tcgtcgtcct ggtgctgctt ctggtcttgg
     5101 cgggcacgat catctccagg tccggtgagg tgtgagccga tccgacctcg aaccttcccg
     5161 tacgtccgga gaacgagctt tagcccaggc cagcgcatgg caaaagttgt ccggctcacg
     5221 gctggcgcac ggctcagggc gctcggctca gggctcgcgg ctcaggaggg gagggcggcc
     5281 ggtggcctga gcagccggtg ccgcagccgc gtgacgagcg gcgccacgcg ggtggccagg
     5341 tcgcgggccg cgatgccggc cctggtggcg ggcacgatga gcgacgcggc ctgcgcgatg
     5401 ccgcgctgct tcggctcgac caggcggcgg tgcgcctgct cgtaccgctg gaaggcggcc
     5461 tccgggtcgc ccggcgtggc ggccagctcg ccggcgagcg tggccgcgcc cgccatggcc
     5521 agcgtcgagc cgtcgccgaa cagcgacacg cacgacccgg cgtcgcccag cagcacgacc
     5581 cgcccgctgg accagcgcgg caggcggacc cggctcaccg agtcgaagta gaggtcgccg
     5641 gcggtgcgca cccgctccag cagctccggc gcgcgccagc ccacgcccgc gaacgccgcg
     5701 gccagcagcc gcttgtgctg ctcggtgtcg cggtggtcga agccgggctc ctgcggcgcg
     5761 cggtagagga agaaggccag gtcgccggac ggcgtggggc tgacggcgac ggcctggccg
     5821 ggggtgttgt gcatcagcac gtcccggccg ggacccgcct ggccgccgat cggggtggtg
     5881 gccacgtaca ggcccatgtg gcgcacctcg gccgcgccgg ggccgaacgc cagccgccgg
     5941 gtcaccgagt gcagcccgtc ggcgcccacc accaggtcga agcggcgggg cgcgccgcgc
     6001 tcgaaggtga cgtccacgcc gccggcatcc tgggtgaggg tggcgatcga gtcgccgaag
     6061 acgaactcgg cgtggtcgcg ggcgcgctcg tacaggatcg aggcgagcgc gcctcgcggc
     6121 agctcgacct cgcccgcgcg ctgcccggcg gccaggtcca tccgggcgac ggtccggccg
     6181 tcgccgtcga cgaagctgag cccggtgttg ccggtggcgg cctcgtgcag ccgcggcagg
     6241 acgcccatgc gggcggccac gtccacggcc ggcccccgca cgtccaccgg gttgccgctg
     6301 gagcgcaggt ccgcggcgcg ctcgacgacg gtgacgcgga aaccgtgccg ggccagccag
     6361 tacgcgagcg tcggcccgcc cacgccggcg ccggagatca gcacgttcat gacccgcctc
     6421 ccaatatctg gaggaatttc ctccacttgt ttgacggtag cataagcgga ggacaaacct
     6481 ccagtcgtgg aagagggaga caatggccga ggcgcaggga ctgcgggcgg acgcgcgccg
     6541 caaccgcgag ctgatcgtgg cggcggcccg cgagctgttc ctggagcagg gcgtggacgt
     6601 ggcactggag gaggtcgcgc gccgggccgg cgtcggcatc ggcaccctct accgccgctt
     6661 ccccgaccgc gacgcgctgc tgcacgccgt cggcgagcag accctcaccc gcctggccgg
     6721 cctggccgag gccgcctggg ccgaggagcc cgacgcctgg cacgcgctgc gccgcttcct
     6781 gcgcggctgc gccgagctgc gcctgggcga gctgtcgtcc aagctggacc cgcacctgca
     6841 ccagccgctg cgcgccggcg acgacctgcg cgagctgcgg cagcgctcga tcgacctgct
     6901 gctgcggatg accgagcggg cgcaggccga cggccacctc cgccccgaca tcggccccgg
     6961 cgacctcgcc ctgctgatga ccctgcacgt ccacaccccg cccgggctgc ccgccggcga
     7021 ggccgtcgcc cgcgtcacgg agatcgtcct ggacggcctg cgcgccggcc ccggcgccac
     7081 ccccctgccc ggcaccgcgc tgagcggcga cgatctcgtc cgccacacgc agtccggctg
     7141 aaatacccga ttgcccggcg gtggcccccg gcgggaggat ctccgccatg ccctactact
     7201 cagcccacga cgggacccgc ctcgcctacc acacctcggg cgccggcgac ccgctgatct
     7261 gcctgcccgg cggccccatg caggacgcca cctacctcgg cgacctcggc ggcctggccg
     7321 cgcaccggcg gctcatcctg gcggacccgc gcggcaccgg cgactccgac cggcccgacg
     7381 accccgccac ctaccgctgc gaccggctcg tggacgacgt cgaagccctg cgcgaacatc
     7441 tcggcctcga ccgcgtcgac ctgctcggcc actccgccgg cgggaacctc gccgtcctgt
     7501 acgccacccg gtaccccgac cgcgtcgccc ggctcctcct gatcgcgccc agcaccaagg
     7561 ccgtcggcct ggagcccacc ccgcaggccc gcctggaggc ggcgaagctg cgcgccggcg
     7621 agccctggtt ccccgaggcg ttcgccgcat tggagcaggt ccaggccggc accgccaccg
     7681 ccgcgacgtg ggaggccgtc gatcccttca tgttcggccg gtgggacgac gcggcgcgcg
     7741 ccttccagga gctctgcgac cggcaccgga acgacgaggc cgccgccgtg ttcggcgcgg
     7801 agggcgccta cgacccggag gcgacccgcg cggctctggg ctgcttcgcc gcgccggtgc
     7861 tggtgctggc cggcgagctc gacctcaaca cgctcccgtc cgccgccgcc gagtacgccg
     7921 cgctgttccc cgccgccgag ctcgtcgtgc agcccggcgc gggccactcg ccgtggctcg
     7981 acgacgccga cgcgttcgtg gcggcggtga cggctttcct cggccgttct agctgaggcc
     8041 gccgttgctc agcaggagct gcccgttgat ccacccgccc tgcggcgagc acaggaagga
     8101 caccaggtca gcggtgtcgc gcggggtgcc gagccggccc agcggcgtca ggcgcagcag
     8161 ctcctcgcgc gtcccgtccg acatccagcc ggtgtccacc gggcccgggt tgacggcgtt
     8221 ggcggtgacg ccgagatggg ccagctcgcg cgcggcggcc agcgtgatgc ggtcgagggc
     8281 gcccttgctg gcgccgtagg gcaggttgcc caccgtgtgg tcgctggtca gggcgatgat
     8341 ccggccggtg ccgtgggcgc cggcgaagcg ccggccgtac tcgcggatca gcagccacgt
     8401 ggcgcgcgcg ttgaccgcga agtgccggtc gaagctctcc acggtggtgt cgagcaggcc
     8461 ggagtcgacc gactcgcagt ggcacatcac cagcgccgtc accgggccga ggcggcgctc
     8521 ggcctcgtcg aagacgaacg ccggggcttc ggggtccgac aggtcggcct cgatcgcggc
     8581 ggtggcggcg ccgcgggcgg tcagggtctc ggcgatggcc tcggtcgccc cggcctcgac
     8641 gccccaggtc atgcgctcgt cgtacggcgt ccagaaggtg aaggcgacgt cccagccgtc
     8701 ggcggcgagc cgctgcgcga tgcccgcgcc gatcccgacc gtgcggccga cgccggtcac
     8761 cagtgccagc ggacggggag cgcggggcgt gtcatgtgca ggtgtcacac gacatgatcc
     8821 tcaagggcgc gacacccgcc cggcaactca tttccagggg aagagacggt gatccaccgc
     8881 ttcacgaccg gagacctgcc acgagccgct ccggctcgcc caccagcggt ggcgcacccc
     8941 gtgggaccgg gacgcggccc gccgccggct ccgggcgtgg gcggcggacg aacgcctgct
     9001 cgtccacgcc tgccacccgc ccttcgacga gacgccggcg gcccggcagg gaggcgtcgc
     9061 cgcgaggagg gctgccgggc ggagggggag gggccaggga gaggggcgtc agacgcggtc
     9121 ggccgcgatc agcaggtact ggaagctgcc gctcttgtac gcctccagga aggcgtcctc
     9181 gatcccggtg gccaggtgcg tcctggcccg cagctcccag taggggatgg tggcggccgt
     9241 gaggtccacc acgctgaccg gcacgaggcg gtgcgcggcc agctccttga agtaggtgct
     9301 gcgcgagtgg atgtcgcaga tgtagtgggc gttgatctgg ctgatggccc gggagggcag
     9361 gccgtaggcg tcgttgtagc agccggtgat gcagacgtag cggccgccgc ggcgcagcag
     9421 cctggagtgc tcggcgaaca gcagcgacag ctcgacgtac atggtgctct cgttgttcca
     9481 gatggcctgg aagtcgccgg tggggaagcc ggtgtcgagc atgttgcgga agtggaagcg
     9541 caccctgtcg tccacgccgc gctccttggc ctgctggttg gcgaaggcca cctgcgactc
     9601 ggagatggac acgccgtcga cctggcagcc ggtgcgcagg ttggccagga agctggagcc
     9661 gccgcggccc gacccggcgt cgaggacgcg gtgctcgggg cgcagcgggc cgagatgcgc
     9721 gaccagcgtc tcggcctgcg tgctctccag ccggtgcagc tccttgacga cgcgctgctc
     9781 cctggtctcg gccgggccgt cgaggacgga ccagtccacg tcgccgatgc cgtagtggtg
     9841 gtggtagagg ccgtccacct cccccaggcg caggttgacg gggttctcct ccgcgttcca
     9901 gtagtcggcg acggactgct ggtagagact gctcagaacg gggactgcat tcgtggtgac
     9961 ggtcacctcg tgctccttcc tatcgcggtc gatgacggga tcaggactgg tatcgggtgg
    10021 tgctgccgtg ccattcgagc ccgccggcca tccacgcctg cgcgccgcgc aggaaccgct
    10081 tcagctcggg ggagggcagg gccgacagct cccgctggct ctgctcgaac ccgcggacga
    10141 acgcgttgtg caggcggacc gtgcgctcga cggcctcctc ggtggagcag ccctcctcgg
    10201 cggcgatgag cagcaccacg ttggagtcgg gcagctcgtc ggcggcctcc ttggcggccg
    10261 agtgcaggtc gttgaccagc acggaggcgg tgcccgcctg catgagcgcg gtgtggaagc
    10321 gccgctccgc gaacaggtgc gggggcagct cgtaaccgcc gacgatgtcg atgagcgtca
    10381 tggaggtgta gaagctgtcg tgctggcggg ccgcgaggta gcgccacacg ggcggcggcg
    10441 tctccaggta gcgccaggcg gcgtaggcgt cccagctcac gtacatctgg ctcgtgatgt
    10501 tgcacagccg catgacctgc gcggacgtgg cgtggcgggc ggcgtggctg gtggccgagc
    10561 gcagcgagac cagcaccggg tcgttcctga tcgcctcttc gagctgctcg gtgtagccgc
    10621 cggcgtccgg cggcgggtcc atcgccgaca tgaccagggc cagccggggc ggcagctcgg
    10681 tcggcgtggc gccgaggtcg gtctcgtcgg cgtagtagtc gtcggcggcc caccaggcgg
    10741 cgttcatctg cgccgagatc agcagcaggt cggggtcgtc gctgtcgctg tgggtgagca
    10801 tggccagccg cccgaacccg gtcgaggcga actccgccat ccgcccctcg tgcagcccga
    10861 tccgctcggc ccacgcgacc agccgccggt ccacctccgc gccgagcgcg tcgtccacgc
    10921 ggtcggtcgc ggggcagtag agcggcggga acgtgccgtc gccccagctc cgctccccgt
    10981 agggcagcgg cgtcaggacc ggccccctga gggagccgct gggggagggc ggctcgtgcc
    11041 cgtcgttctc ctcgaacggg cgccggtacg gccgcagcgc ggagggcagg ctgagcgtgt
    11101 acgagccgag acccgtcggc ccggcgggga tgtcaaacgg catgacgcgc ctcctgctct
    11161 tcgtggggcg gccgggtcac gagcgcgggg cggcgacgtc gacgtcctcg aggatcccga
    11221 tcgcgtcggg caccaggacc gccaccgaga agtaggcgct gaccaggtac gacatgacgg
    11281 cctgggcgtt gatgcccatg aagcgcacgt tcagccccgg ctcgtactcc tcggggatgc
    11341 ccgtctggta gagcccgacg acgccctggt cgtcctcgcc ggtgcgcagg gccaggatcg
    11401 acgtggtgcg gtgctcggag atcgggatct tgccgcaggg gaagatcggg atgccgcgcc
    11461 aggccggcac ctcgtgcccg ttgacctcgg tgctgcccgc gaccagcccg cgcttgttgc
    11521 actcgcggaa gaacgcggcg atcgccttgg ggtgggccag cagcagccgg gtcttgcggc
    11581 gcatgctgat cagctcgtcg aggtcgtcgg gggtcggcgg gcccgaccag gtgtagatgc
    11641 gctggtcgta gtcggtgttg tggagcagcc cgaactcggg gtggttgagc agctccgact
    11701 cctgccgctc gcgcagctcg tggatggtca ggcggagctg ctgctcgatc tggttcatgg
    11761 ggtcgttgaa caggtcggcg acccgggtgt gcacgcgcag gatggtctgg gcgacgctca
    11821 gctcgtactc gcgggggtgc aggtcgtagt ccacgaacgt gccgtcgatg accggctcgc
    11881 cggtgtggcc cgccgacagg tgcacggccg cctcgccgcg gcggttggcc ggcctgctca
    11941 gcttgtcgag gtagccggcc aggtgctcgc gcagcgccgc cgagcggtcg gcgacgcggc
    12001 gcagcccgtc gcgtggcgcg aacagcgccg tgcacggcgt cgtggccctg aatgtgcacg
    12061 gccagcgggc ctcgtcgtcg gtcagcacct cgtcgccgaa ctggtcgccg tcggcgatga
    12121 cgccgaggaa ctgggggttg ccgtaccggc cggtggacac gcgctcgacg cggccgtgcg
    12181 cgatcaccca ggcgccggtg accgggtcgc cttcttcggc gacgacgtcg ccgggccgca
    12241 gctcgcgcgc cgtgaactcg ccggcgatgg ccgccagcac gccgtcgtcg ccgaacccgc
    12301 gcagcgccgg gatctccgtc agcgtccccg gcacgatccg cgcgtcgccg gcgccgcccg
    12361 gcaccacgcc gacgcgcccg cgcccgggcc ggtgcgtcag gcggcggttg acccggtagg
    12421 tgccgccgcg cacgtcgacc cagggcagca tgcgcagcag ccagcgggag ctgatggcct
    12481 gcatctgcgg gcgggtcttg gtcgtcgtgg ccaggttgcg cgcggcccgg gtgtccaggc
    12541 tgagccgggt ttccgtcggg tccgtgggca ttgttcctcc ggggggtcgg ctgccagtcg
    12601 ctactaaaag tagttatatg gccactgagc gtagagtctc ttgatcgata ggaaagctgt
    12661 cgggcaggtg accccgatgt ggccgatcag ttactgtccg tgacagcagg aggaagcatg
    12721 aacgacctgt acgaccgcgt cgccatcgtg accggagccg actccggcat cgggaaggcc
    12781 accgccgtgg cgctggccga gcaggggttc gacgtcggca tcacctacca ctccgaccgc
    12841 gacggcgcgg aggagaccgc ccgcctcgtc cgcgagccgg gccaggcggc cgcgatccgg
    12901 cagcacgacc tcaccgaccc cgaacgggcc gccgccgtcg tggacgagct ggccggcgag
    12961 ctgggcgggc tcggcgtcct ggtgaacaac gccggcaccg gcagtcacga gccgctgctg
    13021 gagatgggct acgagcgctg gcgccagatc ctggccgtcg acctcgacgg cgccttcctg
    13081 tgcgcccagc gggccgcccg ccgcatggtc ggcaccgggc gcggcgggcg gatcgtcaac
    13141 gtcaccagcg tgcacgagga gtacccgaag atgggttcgg gcccctactg cgccgccaag
    13201 ggcgggctgc gcatgctcag ccgcgtgctc gcgctggagc tggccgacca cggcatcacg
    13261 gtcaacaccg tcgcgcccgg cgagatcgcc acccccatga ccgggcagga ggacctgccg
    13321 ccgcagcggg gcagccggcc cggcaacccg atccccaggc cgggcgacgc ccgcgaggtc
    13381 gccgccgtcg tggccttcct ggcggggccg acggcgtcct acgtgaccgg ggcgacggtg
    13441 ttcgtggacg gcggcatgac gctcatgggc ccgcagggcg cctcggcgct cggctcgggc
    13501 gactggcgcg agctgtaggc gcccggggcg ggcatcgtct accagtcgct accagccgct
    13561 acgagccgcg gccgcgcagg aacgcggcgc agcggtgcgt ccagtcggcg acgaccggat
    13621 cctcatcggc cagcccgagg ccgtgcctgc cgctcgggta cacgtgcacc tcctgcgcca
    13681 cgccgtgccg ggccagcgcc tgcgagagca tcagcgtgtt ctcgacgggc acggcctcgt
    13741 cgtcggccgt gtgccacagg aacatcggcg gcgtgtccgc ggtcacccgg ctcgccagcg
    13801 acagctccgc gcgcagggag tcgggggcgt ccgcgccgag caggttgtcg gaggagcccc
    13861 ggtgcgcggc cgggccggtc agcgcggtga cggggtagca cagcacggcc aggtcaggac
    13921 ggtggtcggc ctcgtccacg gcgtcgtgcg ggccctccgc cggcacgggc cccttctcgg
    13981 tggccagcag cccggccagg tgcccgcccg ccgagaaccc cagcaccccc acccggcccg
    14041 gatccacccc caggtccgcg gcgtggtgcc ggacccagcg caccgcccgg gcggcgtcca
    14101 ggagggggag cgggtggcgg tgcggcgcga tccggtaccg caggacgaac gccgccaccc
    14161 cgagcgcgtt cagccaccgg gcgaccggcg cgccctcgtg gtcggccagg tgctggtagg
    14221 ctccgccggg gcacaccacg accgccggcg ccgggccgtc accctcgacg ggaaaggcgg
    14281 tgatggtggc ctcgccggtc gccggccaca gggggtgctc gctcatgctg gtgcctctcg
    14341 gtgttgcgcg ttgctggtag aaggacgttc agtagccggg gaggacgcgg cgcggcaggc
    14401 cgaggccggg cgctcggcgt cccgggggtc agccggcggt cagggcgttc ccgagcaccg
    14461 aggcgaccgc gtcgcggacg tcctcgggcc agatcggcag gccgtccgtg ccggcgaaca
    14521 tgaggtgcgc ggtgcccacc agcgtcgggg cgagccggcc gatgtcggcg ccgggcgcga
    14581 tgcggcccag ctcccgctcg gcggtgaggt agtcggacag gatcatcccg atctccgtca
    14641 tgaccgggag cccgccgacc ggcctggcct cgcgcagccg ggcgcgcacc tggttgtgga
    14701 aggtgaccag ggcgacgatg gagacggcca ccgggtcgaa gagcttgatc agggcgtcgg
    14761 tgaggttgtc gacgacggtg ccggtgccgg cggagtcctt cagcacgtcg ccctgggccc
    14821 gcatcaggtc gatgcggtcg agcacgaact ccgcgaggaa ggcgtcgaac gactcgaagt
    14881 gccggtgcag cacccccttg gcgcagccgg cctgcgcggt gaccgcccgg ctggtcagcg
    14941 cgtcggggcc gccctgccgc agcacctcct cggccgcggt gaagagctgc tcccgcgggt
    15001 cgcgcaggtg tacgccggtc ggcatcgtcg atcctcttcc gcctgggacc acgccgttcg
    15061 attgactaac gggcgcctgc ccactagggt gagccgacgt tcactatagc gcagcggccg
    15121 ccctggcgat cagcgacctg cgcagcagcg gcctgatcac cgcgagctgg gccaccgcca
    15181 gcaggaggca ggtgagggcc agcgtgcccc acaatcccgc cggccccgcg cgatcgagga
    15241 gctgcgtgcc gcacaggggc gccagcacgg tggcgaagcc ccacgagatg ccgaagaccg
    15301 acaggtagcg cccgcgcgcg tcctccgggg cgaggtccac gaccagcgcg tagctgcggc
    15361 cgaacatcag cacgtcgccc gcgctccaca ccactgtcgc ggccaggtgg cccgccagcc
    15421 cgtccgccac cgcgtagccc gcgaggccgg cggcgaggag caggtagccg tacgccatcg
    15481 ccgcgtggtg ggacagcgcc gccgtccacc gcaccagagg ctggcaggcc accatggtga
    15541 cggccgcgac ggccgacagc agcccggcgt cggccgcctc caggccgcgc cgcgcgagcg
    15601 ccagcggcat cgccatcccg gcctgcatga agatcacggc ggagagggtg ccggacagga
    15661 gcagcaacag gagcccgcga tcccgccaga ccgaccctga gtgtgcgggg aggggccggg
    15721 tttcggcgtg gtgcggaagg tggtcggcgg gcaggacgag gcggacgacg atcgcgcaga
    15781 gcacgcagct caccgcgtcc gccacgaaca gccagcgcag gtcccaccgg ccgagaccgg
    15841 cggcgatcag gcccgcgccc atgccgccca ccgccagcgc cgtgttgaac aggctgaacg
    15901 cccgcgcctg ctgggccggc cgcacggcgt ccgcgatcat cgcctgggac ggcggctcgt
    15961 agagctcgaa gaccagcccg agcaggacgg cgaacacggc gaccatcgcc acggacgacg
    16021 acaacgcgat gcccgcctgc gccagcgcgc acccggccag cccggccacg atcgtgcggc
    16081 ggcggccgaa ccggtcggcc agcacgccgc ccagcagccg cgaggggatc gtggccaggc
    16141 cgaacgcggc cgagatcgcg cccgcggcga ccgcgcccac cccgaagtcg gtggtgatca
    16201 ggacggtgag gaagccgagg gagaaggcgc ccagccggtt gatcgcgcgc gccagcacga
    16261 gccaccacac cgtacgcggc aggcgctccg tacgctcgag aaccggcatg aacgcctccc
    16321 gcgtgaccga ccaagctgct aacgtcggtc acgaccctag agcgcgaaag gtgaccagtc
    16381 aagtgctgtt cgatagtcac gtggcgatcc tgctcgacac cgcggtctcg ctcgtgaacg
    16441 tcctcaccga cggcggcgac cgcggcaagc cgtacgcggc ccccaagggc gacgcgctgc
    16501 ccggcgcgat ccgcgccgtg ctgccgggcg gcgtgccggt gtcgcccgag gaggccctct
    16561 acctggccgg caccacgctg aaggtgcggc gcgtgttcga ggccatggac gagggacgcg
    16621 aggacgacgc cgcggccgtc gtcaacgcgc tcgtcatcag caccggcgcc cggccccagc
    16681 tcgaccgggc gccgggggag ccgtggcagg tgcacttcca cggcgccgac gacagcctcg
    16741 ccgtcggctg gagcgccggc atcgcctccg ccctgaccct ggccatcggc agcgacctcg
    16801 gcggccggct cggcgtctgc caggcccggc agtgcgaccg cgtgtacgtg gacgcctccc
    16861 gcaacggggt gcggcagttc tgctcccgct cgtgccagag ccgcacgaag gcggccgcct
    16921 tccgcgcccg ccacgccgcc cgctgagcgt tcccgggacg tcggcgcgtg gttctggcgg
    16981 gcgccggagt cccagggggc gcggcaggag gggcggcggg cgcgcgggcg caggcgcaac
    17041 gtcagcgtca ccgtggtgct cgcgggcagc tccaccgcca ggcacgcccc gcccccggcg
    17101 cctgaggggg ttccccgggc ggggccgcgt gcgtcagcat gcttgggtgc ggacccggcg
    17161 gagggatgag cgcatgctgt cgtacgagcc cctgaccccc accagcttcc tcgaacgatc
    17221 cgccaccgtc ttcggcccgc ggctcgcggt cgtggacggc gagctggagc tcacctacgc
    17281 cgagctgtgg cagcgcgtcc agcgcctggc gggcgcgctg gccacggccg gggtgcggcc
    17341 cggcgaccgg gtggcggtgc tcgcgctcaa cgggcacctg ctgctggagt ccacgttcgg
    17401 cgtgccggcg gcgggcgccg tcatggtgcc gctgaacatc cgcctgtccg ccggcgagct
    17461 ggcctacatc atcggccacg ccgaggtgac gctgctcctg cacgacgacg ccctcaccgg
    17521 cctggccagg caggcggccg aggggaccga ggtgcggctg gtgtcggcca ccgcctgtga
    17581 gacgctgctg gccgtggccg agccgctgct ggtcagggtg gaggacgagc tggcgccgct
    17641 gtccatcaac tacaccagcg gcaccaccgg ccgcccgaaa ggcgtcgtct accaccaccg
    17701 cggcgcctac ctccaggcgc tggccatggc cctgcacacc cggctcgacg ccgcctcctc
    17761 ctacctgtgg acgctgccga tgttccactg ccacggctgg tgcttcccgt gggcggtcac
    17821 gctggccggc gcccggcacg tctgcctgcc gaggatggag ccggacgagg cgtggcggct
    17881 gatccgcgcc caccgcgtca cccacctgtg cggcgcgccg accgttctca cctcgctgct
    17941 cgcgcacgac gacgctccgg cgcgggcgtc ggacccgcgc ctgctcgcct gcgtcggcgg
    18001 cgcgcccccg agccccgccc tgctcggccg ggcgctgcgg gccggcatcg acgtcatcca
    18061 tctgtacggg ctcaccgaga cgtacgggcc cgtcgccatc tgccagcccc agcccgaatg
    18121 gtctgacctg ccggtggcgg agtcggccgc gctgaccgcc cgccagggcg tgggcaacgt
    18181 gatcgcccag cgcctgcgcg tcgtcggcga cgacggccgc gacgtgcccg ccgacgccgc
    18241 caccgtcggc gagatcgcgg tgcgcggcaa cgacgtcatg ctcggctacc accgcgaccc
    18301 ggccgccacg gacaaggccg cgcccgacgg ctggttccgc accggcgacc tcggcgtgct
    18361 gcaccccgac gggtacgtgc ggatcgtgga ccgggccaag gacgtcatca tctccggcgg
    18421 cgagaacatc gcctccgtcg aggtcgagaa cgtgctggtg gagcatcccg gcgtgcggga
    18481 ggccgccgtc gtggcccggc ccgacccgca ctggggcgag gtcccggtcg cgtacgtgag
    18541 cctggccgcc ggggcgcgcg ccaccgaggc cgagctgatc gagcacgtcc gcgcccgcct
    18601 ggcgcacttc aaggcgccca aggcgatcac cttctgcgag ctgcccaaga cctccaccgg
    18661 caagatccaa aagaacgtcc tgaggcagcg cgccgcaggt tagccgccgc ccaggaggga
    18721 agggcccacc cacagagcac ggacgggtca agggggcgtc atggtctctt cgcgcagcgt
    18781 cttccggcgc aagcccgtgg cacagatcgc cacggagcac gagggggagc tgtccaggtc
    18841 gctcgggctg tggcagctca ccgccatcgg cgtgggcggc atcatcggcg cgggcatctt
    18901 cgcgctggcc ggcgcggtcg ccaacgagag cgccggcccg gcggtgctcg tctcgttcct
    18961 catcgcgggc atcgccagcg ccgccgccgc gctctcctac gccgagttcg ccggcctcat
    19021 cccgaaggcc ggctccgcct acacctacgg ctacgccgtc ctcggcgaga tcgtcggctg
    19081 gttcatcggc tgggacctgc tgctggagta caccgcgatc gtcgccgtcg tggcgatcgg
    19141 catctccggc tacttcggct tcctcgtcca gcagctcggc ctcacgctgc ccgcgtggtc
    19201 gctcggcgcg cccggcaccg ggccaggcca cgtggtcgac ctgttcgcgg cggtgctgtg
    19261 cctgctcatc gcggccctgc tgaacctcgg gatccgcgcc gcggccaggt tcgagacgtt
    19321 cgtggtggcg atcaaggtgg cggtcgtgct gctggtcgtc gtggtcggct tcttccacat
    19381 caacaccgcc aactacaccc cgttcttccc gttcggggtc ggcggcgcca tcaccggcgc
    19441 ggccaccgtg ttcttcgcgg tgttcggcta cgacgcgatg agcaccgccg ccgaggagtc
    19501 gcgcgacgcc cagcggcaca tgccgaaggc gatcatctac tcgctgctca tctccatggt
    19561 cctgtacgtg ctggcctgcc tcgtcctgac cggcatgcag aactaccgcg acatcgaccc
    19621 ggagagcggc ttctcctccg ccttcgccgc cgtcggcctg tcggggctgg cgtcggtgat
    19681 cgcggtcggg gccatcgtcg gcatcctcac cgtcatgttc acgttcatgc tcggcgtcac
    19741 ccgcgtctgg ttctccatga gcagggacgg cctgctgccc gcctggttcg cccggctgca
    19801 cccggtccgc agggtgccca cgcgcgtcac ctggatcgtg ggcgtcgcct cggccctcat
    19861 cgccgggttc ctgcccatca aggaggccgc cgagctgacc aacatcggga tcctgctggc
    19921 gttcgtcgtc gtgtgcgtgg cggtgatcgt gctgcgttac cggcagccgg acctgccgcg
    19981 cacgttccgc acgccgtgga tgcccgtcgt gcccgccgtg ggcgtgctgt tctcggtctg
    20041 gctgatcacg ttcctgtcgc cggtgacgtg gctgcgcttc gccgtctggt tcctcatcgg
    20101 gctggtcgtc tacttcgcct acagcaagcg gcactccgtc ctggagtgac cgctccgaag
    20161 tgaccgcgtc acatcggctc gctcccggac gtcagtgtgg tgaccgacgc gagacagcga
    20221 gacgaggcgt ggcccgatga acgatcgtga attcctggct gaccggttcg aggcgcaccg
    20281 ggggcacctg aaggcggtgg cgtaccgcat gctgggctcg ctcaccgagg ccgaggacgc
    20341 cgtgcaggag gcgtggctgc ggctgagccg cagcgagccc gacgacgtgc gcaacctcgg
    20401 cggctggctg accaccgtcg tcggccgcgt ctgcctcgac atgctgcgcg cccgcacctc
    20461 gcgccgcgag gagccgctgg aggcgcgcat gcccgacccc gtcgtcagcc ccgccaccgg
    20521 gcccgacccc gagcaggcgg cgctgctggc cgactccgtc gggctggcgc tgctcgtcgt
    20581 gctggagtcg ctggccccgg ccgagcggct ggcgttcgtg ctgcacgaca tgttcgcggt
    20641 gccgttcgag gagatcgcgc cgctcgtcgg ccgctccccg gccacggccc ggcagctcgc
    20701 cagccgggcc aggcggcggg tccgcggcgc cgcgccggtg cccgaccccg acctcgcccg
    20761 gcagcgcgag atcgtcgagg cgttcctcgc cgccgcccac cggggcgact tcgccgggct
    20821 ggtgtccgtg ctcgaccccg aagtggtgct gcgcgccgac gccggcgcgc tgtccggcgg
    20881 cctgcgcgag gtgcgcggcg cggacaacgt ggccggccag gcgctcgcct tccgccgcca
    20941 cgcgccgtcc accgcgcacg ccgcgctggt caacggcctg gccggggtgg tcaacaccgt
    21001 gaacggggag ccgtcggcgg tcatgagctt cacgatcgcg ggcggccgca tcgtcgagat
    21061 cgacatcctc gccgacccgg cccggctggc ccggctcgac ctggccgtcc tgggggactg
    21121 aggccctctt acttggcggc ggg
//
