LOCUS       NZ_CP017717            21158 bp    DNA     circular CON 03-MAR-2024
DEFINITION  [Actinomadura] parvosata subsp. kistnae strain ATCC 55076
            chromosome, complete genome.
ACCESSION   NZ_CP017717
VERSION     NZ_CP017717.1
KEYWORDS    RefSeq.
SOURCE      [Actinomadura] parvosata subsp. kistnae
  ORGANISM  [Actinomadura] parvosata subsp. kistnae
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Streptosporangiaceae; Nonomuraea.
REFERENCE   1  (bases 1 to 13047416)
  AUTHORS   Nazari,B., Forneris,C.C., Gibson,M.I., Moon,K., Schramma,K.R. and
            Setedsayamdost,M.R.
  TITLE     Nonomuraea sp. ATCC 55076 harbors the largest actinomycete
            chromosome to date and the kistamicin biosynthetic gene cluster
  JOURNAL   Medchemcomm (2017) In press
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 13047416)
  AUTHORS   Nazari,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2016) Chemistry, Princeton University, 20
            Washington Road, Princeton, NJ 08544, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 18-JUN-2015
            Assembly Method                   :: Celera Assembler v. Jun 2015
            Assembly Name                     :: SmrtPipe 1.87.139483
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 110.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/03/2024 13:15:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 12,000
            CDSs (total)                      :: 11,919
            Genes (coding)                    :: 11,783
            CDSs (with protein)               :: 11,783
            Genes (RNA)                       :: 81
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 136
            CDSs (without protein)            :: 136
            Pseudo Genes (ambiguous residues) :: 0 of 136
            Pseudo Genes (frameshifted)       :: 36 of 136
            Pseudo Genes (incomplete)         :: 98 of 136
            Pseudo Genes (internal stop)      :: 10 of 136
            Pseudo Genes (multiple problems)  :: 6 of 136
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:57:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2100707
            Orig. end                         :: 2121865
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP017717.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21158
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="9"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..21158
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21158
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11158](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11158
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     gene            131..760
                     /locus_tag="BKM31_RS09445"
                     /old_locus_tag="BKM31_09405"
     CDS             131..760
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012887147.1"
                     /locus_tag="BKM31_RS09445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_09405"
                     /product="cysteine hydrolase"
                     /protein_id="WP_080037788.1"
                     /transl_table=11
                     /translation="MFQAYDPGRTAVLLVDPYNDFLSEGGKIWPRVRPVAEQVGLLDHL
                     RAVVAAARGAGLRVMIVPHRRWEPGDYETWDHPNPTQRGIMERHSFARGTWGGEFHPDF
                     RPRPGDVVAREHWAQSGFANTDLDFQLKQHGISHVVLIGLLANTCIESTGRFAMELGYH
                     VTLVRDATAAFLPEMMHAAHELNGPTFAHAITTTDELTAAFEQAST"
     misc_feature    875..890
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.94"
                     /tool="antismash"
     misc_feature    complement(877..891)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.93"
                     /tool="antismash"
     misc_feature    complement(878..893)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 20.22"
                     /tool="antismash"
     misc_feature    complement(887..900)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.44"
                     /tool="antismash"
     gene            909..1742
                     /gene="aztB"
                     /locus_tag="BKM31_RS09450"
                     /old_locus_tag="BKM31_09410"
     CDS             909..1742
                     /codon_start=1
                     /gene="aztB"
                     /gene_functions="other (smcogs) SMCOG1245: ABC transporter
                     protein, integral membrane"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014908196.1"
                     /locus_tag="BKM31_RS09450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_09410"
                     /product="zinc ABC transporter permease AztB"
                     /protein_id="WP_080037789.1"
                     /transl_table=11
                     /translation="MDWLFDPFQVSFVRQALWAGVLVSLLCALAGTWVVLRGMAFLGDA
                     MSHGMLLGVALASMAGVDILIGALLSAGGMAYGVSVLGRSARLSQDTGIGLLFAGMLSL
                     GVIVVSHSRSFAVDLTGFLFGDVLAVTGEDLAGLGVALAVTAVVAALGHRPFVALAFDP
                     RKAHTLGMRPGVAHVLLLGLVTLAIVASFHIVGTLLVFGLLIGPPAAAALWARRIPTIM
                     LGAALLGIVSTVAGLIVSWYAATAAGATIAAVAVGLFFLSALGDFLRRRPLAVAR"
     gene            1739..2887
                     /locus_tag="BKM31_RS09455"
                     /old_locus_tag="BKM31_09415"
     CDS             1739..2887
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017596643.1"
                     /locus_tag="BKM31_RS09455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_09415"
                     /product="hypothetical protein"
                     /protein_id="WP_080037790.1"
                     /transl_table=11
                     /translation="MSRAIAILTAGILLAGCAQKGGAAEPAQTPHGYVEGAEETAEPQL
                     RLVLSDGETGQAHVLDPVTGRTTKLPAAKVRAIEGTGRYAFLTTAQGTLQVIDSGGWTV
                     DHGDHVHYYRAPARDLGTIAGRPPYEVTGDAAITAVRSGDGTVTLLDRTRLDRGERAET
                     GRLTADAVVPYGERLLVAQDGAVQVRPRTGEPGSEVGTCADPAGTAVTRRGVVLGCADG
                     ALLVTERNGTFESEKIRYPRGTTEAGRARAFLHRPGSSTLAAKAGDQGVWVLDVTAATW
                     RLLRTGPVLAVNATGDDTPVLSLTRDGVLRAHDPRTGKQTARTKLLTAPAATAAIHVDT
                     ARAYVNDPAAKAVHEIDYNDGLRRARTLTTDLAPAHLTETGR"
     gene            2884..3792
                     /gene="aztC"
                     /locus_tag="BKM31_RS09460"
                     /old_locus_tag="BKM31_09420"
     CDS             2884..3792
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /gene="aztC"
                     /gene_functions="transport (smcogs) SMCOG1252: cation ABC
                     transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017586067.1"
                     /locus_tag="BKM31_RS09460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_09420"
                     /product="zinc ABC transporter substrate-binding protein
                     AztC"
                     /protein_id="WP_080037791.1"
                     /transl_table=11
                     /translation="MRALLGLLAALALAATGCAATGASPPRVVVTTDILGDVTKAVVGG
                     QAEVTVLMRPDSDPHSFGVSAREAARIETADLIVYNGLGLEEGVLRNVEAARRAGVPAL
                     AVAEGVDPIAFTADETAGQPDPHFWTDPARMAKAVDLIAGQVVAHVDGVDAAAVRASAA
                     AYRQQVERLDAWVGQQVATLPAGARRLVTNHHVFGYFARRYGFQVVGAVIPSGTTLASP
                     SASDLKSLSDAIRRTGVKAVFADSAQPDRLARVLASEAGVDVKVVPLFSESLSRRSPGA
                     ATYLEMVRSNTTAIVDGLDGR"
     gene            3820..5016
                     /gene="aztD"
                     /locus_tag="BKM31_RS09465"
                     /old_locus_tag="BKM31_09425"
     CDS             3820..5016
                     /codon_start=1
                     /gene="aztD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019045987.1"
                     /locus_tag="BKM31_RS09465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_09425"
                     /product="zinc metallochaperone AztD"
                     /protein_id="WP_080037792.1"
                     /transl_table=11
                     /translation="MTRTAAAPAALLAAALLLTACGSGQEPATRAAAPAAQSATPAPAA
                     QPSTTVTAPLVLTHDGGLYVLDGQSLELVKDLPLPGYNRVNPAGDDRHVLVSTATGFRV
                     LDAASATLKDDEFKGSKPGHVVRHAGTTALFADGTGEVTLFDPDELAAGLPKGEVYRAA
                     TAHHGVAIQLENGELVVTLGTEEKRTGILVLDKDRKEITRSEDCPGVHGEATAQDEAVV
                     LGCEDGVLLYRNGEITKIDSPDEYGRIGNQAGSDLSPIVLGDYKKDPDAELERPTRISL
                     IDTRTGTLKLVDLGTSYTFRSLARGPRGEALVLGTDGAVHVIDPAAAKVVRTIKVLDAW
                     KEPLDWQRPRPNIFVRDQVVYVSDPEGKKLHAVDFASGKVTRSTSLPQLPNELTGVTS"
     gene            complement(5023..7416)
                     /locus_tag="BKM31_RS09470"
                     /old_locus_tag="BKM31_09430"
     CDS             complement(5023..7416)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013124.4"
                     /locus_tag="BKM31_RS09470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_09430"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_080037793.1"
                     /transl_table=11
                     /translation="MSEGHGEDVRFEVLGPLRAWRARDTLTLGSGRQRVALAVLLLHAN
                     RPVSRDRLIDELWGGRVPAYAVNLLQKHMSSLRAGLEPGRRGRAPSGTLAWTEAGYVLR
                     VPSGGLDLEVFEQEVRRAREARCAGDLRLASHAFHEALRLWRGPVCDGLGSPFVDMMRD
                     QLDERRVGAIEDCMEVDLALAGPGTPLDTAVGSQADLVAELRWLVAHHPLRERLHGLLM
                     LALYRSGRQGEALAAFHDARRRLREELGVEPGALLQGLHQRILAADPDLMTLSAPPSQP
                     EVLPIVSPPRPAPAPHHPPDETRKPSAGRRRATARSTAANGTATSGSGTGGAEAGAAGR
                     GRRVARPWLTPAQLPHDVPRFVGREAELERLDALLADGHDHSGAVVLTGMAGVGKTALA
                     LHWAHRIRDRFPDGQLYVNLRGFGPTVTAMEAAEAIQGFLEAFAIKPDQVPAGLHARAA
                     LLRSLLAGRRMLIVLDNALDAEQVRPLLPGAPGCLAVVTSRDRLTGLVAVEGAHAFVVD
                     LLPKEAARLLLTRRSSAGRAATGPGEAALDEIVAYCGRLPLALSIAAARVATGPCLPFA
                     ALAAELRGARARLDPFDGGEQATDVRAVFSWSYRRLTPPAARLFRLLGLHPGPDFTPAA
                     AASLAGLPPPDARPLVAELARTSMLSERVPGRFACHGLLRAYACELSDAHDSRDERRTT
                     LHRLLDHYLHSAHQAGRILRPGRGTDDLPADLRPALPLVTPESPADRGAARTWFTAEHL
                     VLLAAARRAAEAGFVTHAGQLARTVASFLDPRGIWRVQVDPASP"
     misc_feature    7430..7447
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.22"
                     /tool="antismash"
     misc_feature    complement(7553..7567)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.74"
                     /tool="antismash"
     misc_feature    complement(7555..7571)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.77"
                     /tool="antismash"
     gene            7831..9882
                     /locus_tag="BKM31_RS09475"
                     /old_locus_tag="BKM31_09435"
     CDS             7831..9882
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014911688.1"
                     /locus_tag="BKM31_RS09475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_09435"
                     /product="prolyl oligopeptidase family serine peptidase"
                     /protein_id="WP_080037794.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 2.2e-46, bitscore:
                     157.4, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTSIVPARRDDVREVLGGREVADPYRWLEDPGTPETRDWLAAQA
                     DLFARARDGWPAGGWFRELRQLTSFERLSVPQWRGGRAFYTCLRPGAEHHALMVRDAGG
                     DRALFEPDSADPERRTVLGFWSASADGRLMAYQTAVGGSERFTLRVLDVDTGTNVDEPI
                     TGCRYSAVAWLPGRDAFYYTRHDEDERSGPRLCLHRVGKPADADAVVFGGGADRTAEVD
                     ALVGADGRLLVVQVASGLSAANDVWVADLREAPIERPALRRLPLPEDGWTSAWPAQDGR
                     LYLLTDAGAPRGRLLVTGLSQEPHTLIPEDPEAVLDGFAVLDGLLLVHWTTAGHATVTR
                     HDPATGRLLGEVELPGRGIVTELAPGGQGDEAWFEYSDRVTPETVYRYDAGTGASTAWR
                     RRPAPVTPPVTASETVCRAPDGTPVRILLLAPSWHRAGPLPTILEGYGAFGEPRVADYY
                     AAALAWAGRGGLFAVACVRGGGEGGEAWHQAGRREHKQRGIDDFIAAADHLVAAGHSTR
                     DALGAFGTSAGGLLVGAAMTQRPELFPAVACTAPLLDMARYELTGLGEYWREEFGSRED
                     PEELGWLLGYSPYHRVVPGTPYPAVLLSAFAEDTRVDPLHARKMTAALQFATTSPRPVL
                     LRHEAGAGHGERGRTGRLSYFSDVLAFFAHELGLASITPTEPRGGELP"
     misc_feature    complement(9891..9906)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.01"
                     /tool="antismash"
     aSDomain        10001..10270
                     /aSDomain="Pantocin_Microcin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing E1-like protein in a
                     pantocin/microcin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BKM31_RS09480_Pantocin_Microcin_RRE.1
                     "
                     /evalue="3.50E-11"
                     /identifier="RREFam017.1"
                     /label="BKM31_RS09480"
                     /locus_tag="BKM31_RS09480"
                     /protein_end="90"
                     /protein_start="0"
                     /score="34.0"
                     /tool="antismash"
                     /translation="MTHPVLKTSIPYFIADGSVHFRLGGELTSLEDADGRVSRLLSLLD
                     GTRTPEEVHRDLHAVHPDVTADDVREAIEELDALRLIQSADDAGD"
     gene            10001..11158
                     /locus_tag="BKM31_RS09480"
                     /old_locus_tag="BKM31_09440"
     CDS             10001..11158
                     /GO_function="GO:0008641 - ubiquitin-like modifier
                     activating enzyme activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013094.4"
                     /locus_tag="BKM31_RS09480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_09440"
                     /product="ThiF family adenylyltransferase"
                     /protein_id="WP_080037795.1"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 1.5e-08,
                     bitscore: 34.0, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="ThiF (E-value: 3.6e-41, bitscore: 140.6,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHPVLKTSIPYFIADGSVHFRLGGELTSLEDADGRVSRLLSLLD
                     GTRTPEEVHRDLHAVHPDVTADDVREAIEELDALRLIQSADDAGDDFDGPARERWSNNL
                     GFFETYASLHASKYDFQRRIRDARVAVLGVGGIGSHALIDLVAIGFEDIRIVDFDRIEL
                     SNFNRQILYGEPYVGRVKVEVAAERARALNSAVRIDPVQRKLMSGDDVYEVVRDRDIVI
                     AVVDRPKVHVAHWLNEGCVRAGTALIVGGVDTQRALHYTIVPGVSGCIECWYDQVRGTD
                     PTSLAVMNVLDEIDREGGTFGEDTAAFNGLVLFGAGFLVAEMVRIASRVCPPLSVGRML
                     EMTFHDPRLREAETWKRDPRCATCGDARPKPSLEWLAGDIGPLPL"
     misc_feature    11374..11384
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            11378..12628
                     /locus_tag="BKM31_RS09485"
                     /old_locus_tag="BKM31_09445"
     CDS             11378..12628
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF017760.4"
                     /locus_tag="BKM31_RS09485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_09445"
                     /product="MFS transporter"
                     /protein_id="WP_080037796.1"
                     /transl_table=11
                     /translation="MAQGGVRLRSAFLVSSIGDWIYRFAAPTLILQITGSALSAALAYV
                     LEFIPYIVVGLVAGVIADRWDRRRILITCDCLSFAIALVIAAVAAAERPSVALLYLCAF
                     LLAAVRPFAFPAFQGFIVDTVPQERLSRMNAWTQTVDSSLGFVGPVVGTAFIAALGVPL
                     ATLVNALTFAISALLIYRIAHVSSREKPAAGVRAELSGVGRDFVAGLRILRSIRPVWWG
                     TLLMAAANFAGFVVEGNLVYLILQVEGLPAVALGAVFAAQGLGAVLGAVVAPRLIDRYP
                     TGRLLTSGMALSALAMALPAALPAVGVIAAAWAVEGVATSVIVVSWFTARQTVVPADAI
                     GRVASVSRAAAYATIPVGALAGGAVVGGALAAWGGPVRTLFLCAALVQTAVAAATALSP
                     LRDIHEAVPAPTTPGDP"
     gene            12625..13713
                     /locus_tag="BKM31_RS09490"
                     /old_locus_tag="BKM31_09450"
     CDS             12625..13713
                     /GO_function="GO:0004517 - nitric-oxide synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006809 - nitric oxide biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014897.4"
                     /locus_tag="BKM31_RS09490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_09450"
                     /product="nitric oxide synthase oxygenase"
                     /protein_id="WP_080037797.1"
                     /transl_table=11
                     /translation="MSVSTATAAVVAQEAESFLGLCADGLGWDRERLARRRAAVLDELA
                     RTGTYRHTPAELVLGAKLAWRNHTRCIGKLYWKTLMVRDCRRLHHPDAIAAALTTHLVR
                     AHNGGAIRPIITVFPPDTPTGAGPRIVSPQLVRYAGYERPDGTRRGDPANTGLTRLAGE
                     LGWRGAGGDFDRLPVLIRDARGRLTGHDLPHDACPDVPITHPALPWFAELGLRWYSCPT
                     VSDMRLEIGGVTYPAAPFTGWYVGTEIGTRNFGDRDRYDLLPEVARRLGLDTRDDRTLW
                     KDRALTELNVAVLTSFARAGVRMLDHHTMADHFHRYVQARRRAGEDVHADWSWIIPPTA
                     ASATPVFHDSYDPAILSPNFYR"
     misc_feature    13718..13732
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.91"
                     /tool="antismash"
     gene            13727..14287
                     /locus_tag="BKM31_RS09495"
                     /old_locus_tag="BKM31_09455"
     CDS             13727..14287
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BKM31_RS09495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BKM31_09455"
                     /product="hypothetical protein"
                     /protein_id="WP_080037798.1"
                     /transl_table=11
                     /translation="MIGELFRENIHLSYHQIQIRPQDELGPACPRAFGNGLVALDDEEP
                     DGATILTGIAMGQVEMTVRLAEEAPPLDLDSWEEIVDISIESTFGSLIVCGLDGDLPRN
                     LPNLAWKGPGFYRLRVHAIGRDTDVDGTAFTPTERYAIVSWPAPCPAPDRVHKLTDVFG
                     AEVRDRAPQAGTTWPTRKNPSGS"
     misc_feature    13739..13741
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(14239..15540)
                     /locus_tag="BKM31_RS09500"
                     /old_locus_tag="BKM31_09460"
     CDS             complement(14239..15540)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138: FAD linked oxidase domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541012.1"
                     /locus_tag="BKM31_RS09500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_09460"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_080037799.1"
                     /transl_table=11
                     /translation="MSQPYSSIQEDLRLPGFTGTVHLPGEAGYDEARRSLNPAVDSRPA
                     LIAEAQSVADLRIALLAARAHGLPFAVQSTGHGTHAPCDGGILVKTSAMASVLVDPERR
                     IAHVGPGARWADVIAAAAPFGLAPLSGSAPSVGVTGYTLGGGLGWLARKHGFAADSVLR
                     AEVLLADGRHVTASPSSHPELFWALRGGGAGFGVVTSLEFRLHPVSEVFAGFVYFPIEV
                     AERTLEAYRTWIDDAPDEISTAVVLKRMPGDEQTPAAVRGRHVVMLKVLHAGTAEEGRR
                     LLAPLLAAAGPALLDETRTTTYAATSMGGTPNRHMDMFDTVPGEVVSALVRAAEQAQTI
                     EIRHWGGAMGRPGPDAGPVSHRATKLSVIVDTVVPGLAEELRPYANGGTFLNFLADPAR
                     TAAAFTEADYRRLREVKRVYDPDGFFRVGHVVPA"
     misc_feature    15750..15770
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 20.82"
                     /tool="antismash"
     misc_feature    complement(15754..15772)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 28.73"
                     /tool="antismash"
     misc_feature    15767..15781
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.12"
                     /tool="antismash"
     gene            15809..16843
                     /locus_tag="BKM31_RS09505"
                     /old_locus_tag="BKM31_09465"
     CDS             15809..16843
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1033: iron
                     compound ABC transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131871.1"
                     /locus_tag="BKM31_RS09505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_09465"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_080037800.1"
                     /transl_table=11
                     /translation="MADVPRRALVALGAAALLGVSACGGTAAPPASSAPPASSVQGGSW
                     TWQDDRGKKITLPRRPQRVVAQSAAAAALWDFGVRPVGVFGPHKLKDGGRDPEVGEVDI
                     TKVESIGNVWGEFNVEKYAALRPDLLVAGMYVKDTLWYVPEQSVAAVDQIAPTVGVQLS
                     GKPLVQIIERYGRLAEALGADLTAAPVAEAKKRFEDASAALKRLAADRPGLSVMVVTGT
                     PDSLYVAYLPDHPDLKYWGEDLGLKIVHPERPTESEGGFWEVLSWENADKYQADVILVD
                     ARTQSMKIEEMAEKPTWAKLPAVKAGQLYPWHAAERYSYLGYAKVMEELTTNLDKARDD
                     VVKE"
     gene            complement(16833..17318)
                     /locus_tag="BKM31_RS09510"
                     /old_locus_tag="BKM31_09470"
     CDS             complement(16833..17318)
                     /GO_function="GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541014.1"
                     /locus_tag="BKM31_RS09510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_09470"
                     /product="metallophosphoesterase family protein"
                     /protein_id="WP_080037801.1"
                     /sec_met_domain="Metallophos_2 (E-value: 9e-32, bitscore:
                     109.8, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVVAISDTHAPRRWRACPPRVAEHLRGADVILHAGDVCVPFVLD
                     ELAAYAPVHVVKGNNDGPDVVAPETLELTLGGLRVGMIHDSGPAKGRLARMRRRFPEAE
                     LVVFGHSHIPLDEEGGGLRIFNPGSPTDRRRQPRGTLGLLTIEEGVLVRAEIVPVTP"
     gene            complement(17482..18195)
                     /locus_tag="BKM31_RS09515"
                     /old_locus_tag="BKM31_09475"
     CDS             complement(17482..18195)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012890695.1"
                     /locus_tag="BKM31_RS09515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_09475"
                     /product="SRPBCC domain-containing protein"
                     /protein_id="WP_080037802.1"
                     /transl_table=11
                     /translation="MGRDFELPMEATVGATPEEVWEAISTGPGIDSWFMGRTEVAGGVV
                     RTAFGGFDLPPSRVTDAEPGRHLAHSSDKGDDGRFVAYEFMIEGRERGSTLVRMVTSGF
                     LPGDDWHDEFEAMSKGLEMYFATLVEYLGHFAGRAATPVTEFGPPVADWAAAWERLYAA
                     IGGVPEVGDRVAVNGVEGVVYHRNSQTVGLRSGTAMYRFLQGFGGSMIASHLLFEGGEE
                     QGARWRAWLEQLYAG"
     gene            complement(18198..18782)
                     /locus_tag="BKM31_RS09520"
                     /old_locus_tag="BKM31_09480"
     CDS             complement(18198..18782)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024248.4"
                     /locus_tag="BKM31_RS09520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_09480"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_186403535.1"
                     /transl_table=11
                     /translation="MDEVAVIEDAAAAEASLDPMRSRLLAELVEPGSATSLAAKVGLAR
                     QKVNYHLRTLERHGLVELVEERKKGNVTERVMRATAASFVISPTALSAVQPDPARSPDR
                     LSARWLLALAAQLVRDVGTLITGSAKAQKRVATFAIDGEVRFASAADRAAFAEELAQCV
                     TSLVSKYHDESAEGGRDHRLVVAVHPSVKER"
     gene            complement(18814..20049)
                     /locus_tag="BKM31_RS09525"
                     /old_locus_tag="BKM31_09485"
     CDS             complement(18814..20049)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012891953.1"
                     /locus_tag="BKM31_RS09525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_09485"
                     /product="DUF6596 domain-containing protein"
                     /protein_id="WP_080037803.1"
                     /transl_table=11
                     /translation="MPVSVEGLLRELAPQVLGTLVRRYEQFDMCEDAVQEALLDASVQW
                     PRDGVPDNPRGWLVTVAARRVIDHVRSEHARRRREESVAVSAAADELVVPAPGEDRAGD
                     RDDTLTLLFLCCHPSLSEASQLALTLRAVGGLTTAQIASAFLVPEATMGQRISRAKQRI
                     KASGAEFRLPPEGEREDRLRVVLHVLYLIFNEGYTATSGPELHRAELTGEAIRLTRAVS
                     RLLPDDGEIMGLLALMLLTEARRPARTDGEGRLIPLAEQDRGLWDRRLIEEGVELVTKA
                     LSTTAVGPYQLQAAIAAVHDEAPTAAETDWPQILALYGVLAGVEDNPVVRLNQAVATAM
                     VHGPRAGLSLLDELAADDRMAGHHRLAAVRAHLLEMDGDAKGAVAAYREAARLTTSLPE
                     RRYLEDRASRLS"
     gene            20261..21079
                     /locus_tag="BKM31_RS09530"
                     /old_locus_tag="BKM31_09490"
     CDS             20261..21079
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012893832.1"
                     /locus_tag="BKM31_RS09530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_09490"
                     /product="nucleotidyltransferase domain-containing protein"
                     /protein_id="WP_230466075.1"
                     /transl_table=11
                     /translation="MRTPDLHAIAARLAAVPGVVAVALGGSRARGTHRPDSDIDLGLYY
                     RGDLDVAGLRALAREVTGEETDVTEPGGWGPWVDGGGWLTIDGWRVDWIYRDLDRVHRV
                     WHDCRAGRYEIGVQAGHPLGFYSHAYAGEVALCQVLADPAGELTALREATAQYPPALRD
                     ALVAGLWESDFALTTARYGAAGNDPVYVAGALFRAIGVACHALHAADGAWLINEKGMVA
                     AAGRLPSAPETFGERAQALLAGVGSAPEEITRTIDTAAELLAEVRTACGA"
ORIGIN
        1 gtcgagcacc tggagcagaa cgtggccgcc gcggggctgg agctgaccga ggaggacttc
       61 gacgagctga ccgcggccgg cgcctcgacg agctgacccc gcctttccct acctgcgagg
      121 agcacccgtg atgttccagg cgtacgaccc cggccgtacg gccgtgctgc tggtcgatcc
      181 gtacaacgac ttcctgtccg agggcggcaa gatatggccg cgcgtgcggc ccgtggccga
      241 gcaggtcggg ctgctcgacc acctgcgtgc cgtggtcgcc gccgcgcgcg gggcgggcct
      301 gcgggtgatg atcgtgccgc accgccgctg ggagccgggc gactacgaga catgggacca
      361 ccccaatccc acccagcgcg gcatcatgga gcggcacagc ttcgcccgcg gcacctgggg
      421 cggcgagttc caccccgact tccggccgcg gccgggcgac gtggtggccc gcgagcactg
      481 ggcgcagagc ggcttcgcca acaccgacct ggacttccag ctcaagcagc acggcatcag
      541 ccacgtcgtg ctcatcggct tgctggccaa cacctgcatc gagtccaccg gccggttcgc
      601 catggagctc ggctaccacg tcacgctcgt gcgggacgcc accgccgcgt tcctgcccga
      661 gatgatgcac gccgcccacg agctgaacgg ccccaccttc gcccacgcca tcaccacgac
      721 ggacgagctc accgccgcgt ttgagcaggc gtccacctga gcgggaggcg cgccatggac
      781 gagaaactcg gcgtgcccgt gaccgcctcc ggccggcggc tccgtgcgtc tccacgcgct
      841 cctccagcat gaccctcgca tggctctagt tggaaacgac aacggttttc attgtagagt
      901 cctggcgcat ggactggttg ttcgatccct ttcaggtgtc atttgtccgg caagcgctct
      961 gggccggcgt cctcgtgtcg ctgctctgcg cgctcgccgg cacgtgggtg gtgctgcgcg
     1021 gcatggcctt cctgggcgac gcgatgtcgc acgggatgct cctcggcgtg gcgctcgcct
     1081 ccatggcggg ggtcgacatc ctgatcggcg cgctgctcag cgcgggcggc atggcgtacg
     1141 gggtgagcgt cctgggccgc tccgcccgcc tgtcgcagga caccgggatc gggctgctgt
     1201 tcgcggggat gttgtccctg ggcgtcatcg tggtctcgca ctcccggtcg ttcgcggtgg
     1261 acctgaccgg gttcctgttc ggcgacgtgc tggcggtcac gggggaggac ctggcggggc
     1321 tcggcgtggc gctcgcggtc acggccgtgg tcgcggcgct cgggcaccgg ccgttcgtgg
     1381 cgctcgcctt cgacccgcgc aaggcgcaca cgctggggat gcggccgggg gtggcgcacg
     1441 tcctgctgct ggggctggtc acgctggcga tcgtggcgtc gttccacatc gtcgggacgc
     1501 tgctggtgtt cggcctgctg atcgggccgc cggccgccgc cgcgctgtgg gcgcggcgca
     1561 tcccgacgat catgctgggg gcggcgctgc tcggcatcgt ctcgaccgtg gccgggctga
     1621 tcgtgtcctg gtacgcggcc accgccgccg gcgccaccat cgccgccgtg gccgtggggc
     1681 tgttcttcct gtcggcgctc ggcgacttcc tgcgccgccg tcccctggcg gtggcccggt
     1741 gagcagggcg atcgcgatcc tcacggcggg gatcctgctg gcgggctgcg cgcagaaagg
     1801 cggcgcggcc gagccggcgc agaccccgca cgggtacgtc gagggggccg aggagacggc
     1861 cgagccgcag ctccgcctcg tcctgtccga cggcgagacg ggccaggccc acgtgctcga
     1921 cccggtgacc ggccggacca ccaagctccc tgccgcgaag gtgcgggcga tcgaggggac
     1981 cggccgctac gccttcctca ccacggccca gggcacgctc caagtgatcg acagcggcgg
     2041 ctggaccgtc gaccacggcg accacgtgca ctactaccgg gcccccgccc gcgacctcgg
     2101 cacgatcgcc ggccgcccgc cgtacgaggt gaccggtgac gcggcgatca ccgccgtccg
     2161 ctccggcgac ggcacggtca cgctgctcga ccgcacccgc ctggaccggg gcgaacgggc
     2221 cgagacgggc cggttgacgg ccgacgccgt cgtcccgtac ggggagcggc tgctggtcgc
     2281 gcaggacggc gccgtccagg tcaggcccag gaccggcgag cccggcagcg aggtcgggac
     2341 gtgcgcggac ccggccggaa cggcggtcac ccggcgcggc gtggtcctcg gctgcgccga
     2401 cggcgccctc ctggtcaccg agcggaacgg caccttcgag agcgagaaga tccgctaccc
     2461 gcgcgggacc acggaggccg ggcgcgcgcg ggcgttcctg caccgccccg gcagctccac
     2521 gctggcggcg aaggccggcg accagggcgt ctgggtgctc gacgtgaccg ccgcgacgtg
     2581 gcggctgctg cgcacgggcc ccgtcctcgc ggtgaacgcc accggcgacg acaccccggt
     2641 cctgtccctc accagggacg gcgtcctgcg cgcgcacgac ccgcgcaccg gcaagcagac
     2701 ggccaggacg aaactgctca ccgcaccggc ggccacggcg gccatccacg tggacaccgc
     2761 ccgcgcctac gtcaacgacc cggcggccaa ggccgtccac gagatcgact acaacgacgg
     2821 cctgcgccgc gccagaacgc tcaccacgga cctcgcaccc gcccacctga cggagaccgg
     2881 ccgatgaggg cgctgctcgg cctgctggcg gcgctcgccc tggcggccac cggctgcgcg
     2941 gccaccggcg cgtccccgcc ccgggtggtg gtcaccaccg acatcctcgg cgacgtcacc
     3001 aaggccgtgg tcggcggcca ggccgaggtg accgtgctga tgcggcccga ctccgacccc
     3061 cactccttcg gcgtctccgc gcgggaggcc gcccggatcg agaccgccga cctgatcgtc
     3121 tacaacgggc tcggcctgga ggaaggcgtg ctacgcaacg tcgaggccgc ccggcgggcc
     3181 ggcgtgcccg cgctggccgt ggcggagggc gtcgacccga tcgcgttcac cgccgacgag
     3241 acggccgggc agcccgaccc gcacttctgg accgacccgg cccgcatggc caaggccgtg
     3301 gacctcatcg ccggccaggt cgtcgcgcac gtggacggcg tggacgccgc cgccgtacgg
     3361 gcctccgcgg ccgcgtaccg gcagcaggtc gagcggctcg acgcctgggt cgggcagcag
     3421 gtcgccaccc tcccggccgg ggcccgccgc ctggtcacca accatcacgt cttcggctac
     3481 ttcgcccgcc gctacggctt ccaggtggtc ggcgccgtga tccccagcgg caccacgctg
     3541 gcctcgccca gcgcgtcgga cctgaagtcg ctcagcgacg cgatccggcg caccggcgtc
     3601 aaggccgtct tcgccgactc cgcccagccc gaccggctcg cccgggtgct cgcctcggag
     3661 gcgggggtgg acgtcaaggt cgtccccctg ttctcggagt cgctgagccg caggtcgccg
     3721 ggcgcggcca cgtacctgga gatggtccgc agcaacacca cagccatcgt cgacggcctc
     3781 gacggccgct gaaaccgcta cagaaaggcg caccacacca tgacccggac cgccgccgcc
     3841 cccgcggcgc tgctcgccgc cgccctcctg ctcaccgcct gcgggagcgg gcaggagccc
     3901 gcgacgcggg cggccgcacc cgccgcccag tctgccacgc cggcgcccgc cgcccagccc
     3961 tcgacgacgg tgacggcccc cctcgtgctg acccacgacg gcggcctgta cgtcctcgac
     4021 gggcagagcc tggagctggt caaggacctc cccctgccgg gatacaaccg cgtcaacccg
     4081 gcgggggacg accggcacgt gctcgtctcc accgcgaccg gcttccgcgt cctcgacgcc
     4141 gcctccgcca cgctcaagga cgacgagttc aagggctcga agccgggcca cgtggtgcgg
     4201 cacgccggca ccaccgccct gttcgccgac ggcaccggcg aggtcaccct gttcgacccc
     4261 gacgagctgg ccgccggcct gcccaagggc gaggtgtacc gggccgccac ggcgcaccac
     4321 ggcgtcgcca tccagctgga gaacggcgag ctcgtcgtca ccctcggcac cgaggagaag
     4381 cgcaccggca tcctcgtcct ggacaaggac cgcaaggaga tcacccgcag cgaggactgc
     4441 cccggcgtgc acggcgaggc caccgcccag gacgaggccg tcgtgctcgg ctgcgaggac
     4501 ggcgtcctgc tctacaggaa cggcgagatc accaagatcg acagccctga cgagtacggc
     4561 cgcatcggca accaggccgg ctccgacctg tccccgatcg tcctcggcga ctacaagaag
     4621 gacccggacg ccgagctgga acgccccacc cggatctccc tcatcgacac caggaccggc
     4681 accctcaaac tggtcgacct gggcaccagc tacacgttcc gctccctggc ccgcggcccg
     4741 cgcggcgaag ccctcgtcct cggcaccgac ggcgccgtcc acgtcatcga cccggccgcg
     4801 gccaaggtcg tcaggaccat caaggtgctg gacgcctgga aggagcccct ggactggcag
     4861 cggccccgcc cgaacatctt cgtccgcgac caggtcgtct acgtcagcga cccggagggc
     4921 aagaagctgc acgcggtcga cttcgcctcc ggcaaggtca ccaggagcac gtccctgccg
     4981 cagcttccga acgagctcac cggcgtcacg agctgacccg cctcaggggg aggccgggtc
     5041 cacctgcacc cgccagatcc cgcgcgggtc gaggaacgac gccaccgtcc gggccagctg
     5101 cccggcgtgc gtgacgaagc ccgcctccgc cgcccggcgg gccgccgcca gcagcaccag
     5161 gtgctcggcg gtgaaccacg tccgcgccgc gccccggtcg gccggcgact ccggcgtcac
     5221 cagcggcagg gcggggcgca ggtccgcggg caggtcgtcg gtgccccgcc ccggccgcag
     5281 gatccggccc gcctggtggg cgctgtgcag gtagtggtcg agcaggcggt gcagggtcgt
     5341 ccgccgctcg tcccggctgt cgtgcgcgtc gctcagctcg cacgcgtacg cgcggagcag
     5401 cccgtggcag gcgaaccggc cgggaacccg ctcgctgagc atgctcgtcc tggccagctc
     5461 cgccaccagc gggcgggcgt cgggcggcgg cagccccgcc aggctcgcgg cggcggccgg
     5521 ggtgaagtcg gggcccggat gcagcccgag cagccggaac aggcgcgccg ccggcggggt
     5581 gagccgccgg taggaccagg agaacaccgc ccgcacgtcc gtcgcctgct cgcctccgtc
     5641 gaacggatcc agccgcgcgc gggccccgcg cagctcggcg gccagggcgg cgaacggcag
     5701 gcacgggccg gtggcgacgc gggcggcggc gatggacagg gcgagcggca gccgcccgca
     5761 gtacgcgacg atctcgtcca gcgccgcctc gccagggccg gtcgccgcgc ggccggcgga
     5821 cgagcgccgg gtgagcagca ggcgggccgc ctccttcggc agcaggtcga cgacgaacgc
     5881 gtgcgcgccc tcgaccgcca ccaggcccgt gagccgatcc cggctggtca ccacggcgag
     5941 acagccgggc gcgccgggca gcagcgggcg gacctgctcg gcgtcgaggg cgttgtcgag
     6001 cacgatcagc atccggcggc ccgccagcag gctccggagc agcgcggccc gcgcgtgcag
     6061 gccggcgggg acctggtccg gcttgatcgc gaacgcctcc aggaacccct ggatcgcctc
     6121 cgccgcctcc atcgccgtca ccgtcgggcc gaagccgcgc aggttcacgt acagctgacc
     6181 gtcggggaac cggtcgcgaa tgcggtgcgc ccagtgcagc gccagcgcgg tcttcccgac
     6241 gcccgccatg ccggtgagca ccacggcgcc gctgtggtcg tggccgtcgg cgagcaacgc
     6301 gtccagccgc tccagctccg cctccctgcc gacgaaccgc ggcacgtcgt gcggaagctg
     6361 cgcgggcgtc agccacggac gcgccacccg ccgccccctc cccgccgcac cggcctccgc
     6421 gccgccggtt cctgagccgc tggtcgcggt gccgttcgcc gccgtgctgc gcgcagtggc
     6481 gcggcggcgg cctgccgagg gcttccgtgt ctcgtcgggc gggtggtgcg gtgccggggc
     6541 gggacgcggc ggcgagacga tggggaggac ctccggctgg gacgggggag cggagagggt
     6601 catgaggtcg gggtcggcgg cgaggatgcg ctggtggagg ccctggagca gggcgcccgg
     6661 ctcgacgccc agctcctcgc ggagccgccg ccgcgcgtca tggaaggccg ccagcgcctc
     6721 accctggcgc ccggaccggt acagggccag catgagcagg ccgtgcagcc gctcgcgcaa
     6781 cggatggtgg gccacgagcc agcgcagctc ggcgacgagg tcggcctgac tgcccaccgc
     6841 cgtgtcgagc ggggtgccgg gccccgcgag cgccaggtcc acctccatgc agtcctcgat
     6901 cgcgccgacc cgccgctcgt cgagctggtc ccgcatcatg tcgacgaacg ggctgcccag
     6961 cccgtcgcac accggccccc gccacagccg cagcgcctcg tggaaggcgt gtgaggcgag
     7021 ccgcaggtca ccggcgcagc gcgcctccct ggcgcggcgg acctcctgct cgaacacctc
     7081 caggtccagc ccgcccgagg gcacgcgcag cacgtacccg gcctcggtcc aggccagcgt
     7141 cccggacggc gcccgcccgc gccggcccgg ctccagcccg gcgcgcaggc tcgacatgtg
     7201 cttctgcagc aggttcacgg cgtacgcggg gacgcggccg ccccacagct cgtcgatgag
     7261 cctgtcgcgg ctcaccggcc ggttggcgtg cagcagcagg acggccaagg cgacccgctg
     7321 ccggccggac cccagggtca gggtgtcgcg cgcccgccac gcgcgcagcg gccccagcac
     7381 ctcgaatcgg acatcctctc catgtccttc ggacatcccg cctcctcaga agtaacacga
     7441 gtgttgctgt ccgcgaggtg tggccggacc gtcccggtct tgatccgccg ggaacgcccc
     7501 ctcattcgtc gtgcggcggg acggggatga cgcccgacgg tccgaattca tgacatgtcg
     7561 gaaatttcca gccccgagcc cctttccagc gctttgacca gcgccctttc ctgcgatgcc
     7621 ccagaaagtc ctccagcgac aggtccagga cgcattccag gacgcgctcc aggatgccgg
     7681 ccggtgcggc gaccagcggc gggtccagcg gcgggtccag cgaccgttcc agaccccgcg
     7741 gcgaagcttc ggtggcagcg ggacgcaccc agccggcacg gcgacggagg gagccggaca
     7801 gtgtccgagg tcacgaggtc ttcgggagtc atggacacga gcatcgtgcc ggcgcggcgg
     7861 gacgacgttc gggaggtgct cggcggccgt gaggtggccg acccgtaccg gtggctggag
     7921 gaccccggca cgccggagac ccgcgactgg ctggcggcgc aggccgacct cttcgccagg
     7981 gcgcgggacg gctggccggc cggcggctgg ttccgcgagc tgcggcagct cacctcgttc
     8041 gagcggctgt cggtgcccca gtggcggggc gggcgggcct tctacacgtg cctgcgtccc
     8101 ggcgcggagc atcacgcgct catggtcagg gacgccggag gcgaccgcgc gctgttcgag
     8161 ccggacagcg cggacccgga gcggcgcacg gtgctggggt tctggtccgc ctccgccgac
     8221 ggccggttga tggcctacca gacggcggtg ggcgggtccg agcggttcac gctgcgggtc
     8281 ctggacgtgg acaccgggac gaacgttgac gaacccatca cgggctgccg gtactcggcg
     8341 gtcgcgtggc tgccgggcag ggacgcgttc tactacacgc gccacgacga ggacgaacgc
     8401 tccggccccc ggctctgcct gcaccgcgtg gggaagccgg ccgacgcgga cgcggtggtc
     8461 ttcggcggcg gcgccgaccg cacggctgag gtggacgcgc tggtgggggc ggacgggcgg
     8521 ctgctggtcg tccaggtggc ctccggcctg tcggcggcca acgacgtctg ggtggccgac
     8581 ctgcgcgagg ccccgatcga gcggcccgcc ctgcgccggc tgccgctgcc cgaggacggc
     8641 tggacctcgg cctggccggc ccaggacggc cgcctgtacc tgctgaccga cgccggcgcc
     8701 ccccgaggcc gcctcctcgt gaccggcctc tcacaggagc cgcacacgct gatacccgag
     8761 gacccggagg cggtgctgga cgggttcgcg gtgctcgacg gcctgctgct ggtccactgg
     8821 acgaccgccg gccacgccac cgtgacccgc cacgacccgg ccaccggccg cctcctcggc
     8881 gaggtcgagc tgcccggccg cggcatcgtc accgagctgg cgcccggcgg ccagggtgac
     8941 gaggcgtggt tcgagtactc cgaccgcgtc acgcccgaga ccgtctaccg ctacgacgcc
     9001 ggcaccggcg cgagcacggc gtggcgccgc cgccccgccc cggtcacccc gccggtgacc
     9061 gcgtccgaga cggtctgccg cgcaccggac ggcacccccg tacggatcct cctgctcgcc
     9121 ccttcctggc accgggcggg cccgctgccc acgatccttg aggggtacgg cgccttcggg
     9181 gagccgcgcg tcgccgacta ctacgccgcg gccctggcgt gggccgggcg gggcggcctg
     9241 ttcgcggtgg cgtgcgtgcg cggcgggggc gagggcggcg aggcgtggca ccaggccggc
     9301 cgccgcgagc acaagcagcg cggcatcgac gacttcatcg ccgccgccga ccacctggtg
     9361 gccgccgggc acagcacccg cgacgcgctg ggagcgttcg ggaccagcgc gggcggcctg
     9421 ctcgtgggcg cggcgatgac gcagcgcccg gagctcttcc cggcggtcgc gtgcacggcg
     9481 ccgctcctcg acatggcccg ctacgagctg acggggctcg gcgagtactg gcgcgaggag
     9541 ttcggcagcc gggaggaccc cgaggagctg ggctggctgc tcggctactc gccgtatcac
     9601 cgggtcgtgc ccggcacccc gtacccggcc gtcctgctgt cggcgttcgc ggaggacacc
     9661 cgcgtcgatc ccctgcacgc gcggaagatg accgccgcgc tgcagttcgc caccacctcg
     9721 ccgcgcccgg tgctgctgcg ccacgaggcg ggcgcggggc acggcgagcg gggacgcacg
     9781 ggccggttgt cctacttctc cgacgtgctc gcgttcttcg cccacgagct gggcctcgcg
     9841 agcatcaccc cgacggaacc gagaggaggt gaacttccat gatcaagaag tcgaccaagc
     9901 ggtacagcgt cgccggtggt gcccagaagg gctgatcccg ttgcgggtgg ggcgttctca
     9961 cggggcgccc caccccccgc ccagtcccgg aaggaaagcc atgactcatc ccgtgctcaa
    10021 gacgagcatc ccctacttca tcgccgacgg gtcggtgcac ttccggctgg gcggcgagct
    10081 gacctcgctg gaggacgcgg acggccgcgt cagccggctg ctgtccctgc tggacggcac
    10141 gcgcaccccg gaggaggtcc accgcgacct gcacgccgtg caccccgacg tgacggcgga
    10201 cgacgtccgc gaggccatcg aggagctgga cgcgctgcgg ctgatccaga gcgccgacga
    10261 cgccggcgac gacttcgacg gcccggcccg cgaacgctgg tcgaacaatc tgggcttctt
    10321 cgagacgtac gcctcgctgc acgcctccaa gtacgacttc cagcgccgca tccgcgacgc
    10381 ccgcgtggcc gtgctcggcg tcggcggcat cggcagccac gcgctgatcg acctggtcgc
    10441 catcggtttc gaggacatca ggatcgtcga cttcgaccgc atcgagctgt cgaacttcaa
    10501 ccgccagatc ctctacggcg agccgtacgt gggccgggtc aaggtggagg tggccgctga
    10561 gcgggcgcgc gcgctcaaca gcgccgtgcg catcgacccg gtgcagcgca agctgatgtc
    10621 cggcgacgac gtgtacgagg tggtgcgcga ccgcgacatc gtcatcgccg tggtggaccg
    10681 ccccaaggtg cacgtcgccc actggctgaa cgagggctgc gtccgcgcgg gcacggccct
    10741 catcgtgggc ggcgtcgaca cccagcgcgc cctgcactac acgatcgtgc ccggcgtgtc
    10801 cggctgcatc gagtgctggt acgaccaggt gcgcggcacc gaccccacgt ccctggccgt
    10861 gatgaacgtg ctggacgaga tcgaccggga gggcggcacg ttcggcgagg acaccgccgc
    10921 cttcaacggc ctggtgctgt tcggcgcggg tttcctggtc gcggagatgg tccggatcgc
    10981 cagccgggtc tgcccgccgc tgtcggtggg ccggatgctg gagatgacct tccacgatcc
    11041 gcgcctgcgc gaggccgaga cgtggaagcg cgacccgcgc tgcgcgacgt gcggcgacgc
    11101 ccggccgaag ccgagcctcg agtggctggc cggcgacatc gggccgctgc ccctctgacc
    11161 gtcaccccga cacgcacgcc cagcgagagc agggaggagg tgaaacgcca tgatcaagaa
    11221 gtcgaccaag cgctacagca tcgccggtgg cacgcagaag gcgtagcctc cgccggccgg
    11281 gtggggcgtt tccgggcgcc ccaccccctc gccgccggcg ccacgcacgg ttagtgtccc
    11341 ggtgaacccc tcgtcagtcc gttgggagga ccctgccatg gcacagggag gcgtccggct
    11401 gcgcagcgcg ttcctcgtct cgtcgatcgg cgactggatc taccggttcg ccgcgcccac
    11461 cctgatcctg cagatcacgg gctcggcgtt gtcggcggcg ctggcgtacg tgctggagtt
    11521 catcccgtac atcgtcgtcg ggctggtcgc gggcgtcatc gccgaccggt gggaccgccg
    11581 caggatcctc atcacctgcg actgcctgtc cttcgcgatc gcgctggtca tcgcggccgt
    11641 ggcggcggcg gagcggccgt cggtggcgct gctctacctg tgcgcgttcc tgctggccgc
    11701 ggtgcggccg ttcgccttcc ccgccttcca ggggttcatc gtggacacgg tgccgcagga
    11761 gcggctgtcc cggatgaacg cctggacgca gaccgtcgac agctcgctcg gcttcgtcgg
    11821 gccggtcgtc ggcaccgcgt tcatcgcggc gctgggcgtg ccgctggcga cgctggtcaa
    11881 cgcgctgacg ttcgcgatct cggcgctgct catctaccgg atcgcccacg tgtcttcgcg
    11941 tgagaagccc gcggcgggcg tgcgcgccga gctgtccggc gtgggccggg acttcgtggc
    12001 cgggctgcgc atcctgcgct cgatcaggcc cgtctggtgg ggcaccctgc tcatggccgc
    12061 cgccaacttc gccggcttcg tcgtcgaagg caacctcgtc tacctcatcc tccaggtgga
    12121 gggcctgccg gcggtggcgc tgggcgccgt gttcgccgcg caggggctgg gcgcggtgct
    12181 cggcgcggtg gtggcgcccc ggctcatcga caggtatccg acgggccggc tgctcacgtc
    12241 cgggatggcg ctgtcggcgc tggccatggc gctgcccgcg gcgttgcccg ccgtcggggt
    12301 gatcgcggcg gcctgggccg tggagggcgt ggccacgtcg gtgatcgtgg tgtcctggtt
    12361 caccgcccgg cagaccgtcg tgcccgccga cgccatcggc cgcgtcgcct ccgtgagcag
    12421 ggcggcggcg tacgcgacca tcccggtcgg cgccctggcc ggcggcgcgg tcgtgggcgg
    12481 cgcgctggcc gcgtggggcg ggcccgtccg gacgttgttc ctgtgcgcgg ccctcgtgca
    12541 gacggccgtc gccgccgcca ccgccctgtc accgctgcgg gacatccacg aggccgtgcc
    12601 cgcgcccacc accccggggg atccatgagc gtcagcaccg cgacggccgc cgtcgtcgcc
    12661 caggaggcgg agtcgttcct cggcctgtgc gccgacgggc tcggctggga ccgggagcgg
    12721 ctggcccgcc gccgcgcggc cgtcctggac gagctggccc gcaccggcac ctaccggcac
    12781 acgcccgccg agctggtgct cggcgcgaag ctcgcctggc gcaaccacac ccggtgcatc
    12841 ggcaagctgt actggaagac gctcatggtg cgcgactgcc gcaggctgca ccaccccgac
    12901 gccatcgccg ccgccctcac cacccacctc gtacgcgccc acaacggcgg cgccatccgg
    12961 ccgatcatca cggtgttccc gcccgacacg cccaccggcg ccggcccccg gatcgtcagc
    13021 ccccagctcg tccggtacgc cggctacgag cgcccggacg gcacccgccg cggcgacccc
    13081 gccaacaccg ggctcacccg gctggccggc gagctgggct ggcgcggcgc gggcggcgac
    13141 ttcgaccgcc tgccggtgct gatccgcgac gcgcgcggcc gcctgaccgg gcacgacctg
    13201 ccccacgacg cctgccccga cgtgcccatc acccatcccg cgcttccgtg gttcgccgag
    13261 ctggggctgc gctggtactc ctgccccacg gtgtcggaca tgcggctcga gatcggcggc
    13321 gtcacctatc ccgccgcgcc gttcaccggc tggtacgtcg gcaccgagat cggcaccagg
    13381 aacttcggcg accgcgaccg ctacgacctg ctcccggagg tcgcccgccg gctgggcctc
    13441 gacacgcgcg acgaccgcac gctgtggaag gaccgcgcgc tgacggagct gaacgtggcg
    13501 gtgctgacct cgttcgcacg ggccggggtg cggatgctcg accaccacac gatggccgac
    13561 cacttccacc gctacgtcca ggcgcggcgg cgggcggggg aggacgtgca cgccgactgg
    13621 agctggatca tcccacccac ggcggcctcg gccacgccgg tcttccacga ctcctacgat
    13681 cccgcgatcc tgtcaccgaa tttctaccgg tagtaccatt tttcggatga tcggcgagtt
    13741 attccgggag aacattcacc tgtcgtacca ccagatccag attcgcccgc aggacgagct
    13801 gggccccgcc tgtccgcgag cgttcggcaa cggcctcgtc gccctcgacg acgaggagcc
    13861 cgacggcgcg accatcctca ccggcatcgc gatgggccag gtggagatga ccgtgcggct
    13921 cgccgaggag gccccgcccc tcgacctgga ctcctgggag gagatcgtcg acatctcgat
    13981 cgagtcgacc ttcggctcgc tcatcgtgtg cggcctcgac ggggacctgc cgaggaacct
    14041 gccgaacctg gcgtggaaag gccccggctt ctaccgcctg cgcgtgcacg cgatcggccg
    14101 tgacacggac gtcgacggaa cggccttcac ccccaccgaa cgctatgcga ttgtctcctg
    14161 gcccgccccc tgccccgcgc ccgaccgggt gcacaagctg accgacgtgt tcggcgcgga
    14221 ggtacgcgac cgggcacctc aggccggcac gacgtggccg acgcggaaga acccgtccgg
    14281 gtcgtagacg cgcttgacct cgcgcagccg ccggtagtcc gcctcggtga acgccgccgc
    14341 cgtccgcgcc gggtcggcca ggaagttcag gaacgtcccg ccgttggcgt acgggcgcag
    14401 ctcctccgcc agccccggca ccacggtgtc cacgatcacc gacagcttgg tggcgcggtg
    14461 gctcaccggc ccggcgtccg gcccaggacg gcccatggcg ccgccccagt gccggatctc
    14521 gatcgtctgc gcctgctccg cggcccgcac cagcgcggag acgacctcgc cgggcacggt
    14581 gtcgaacatg tccatgtgcc ggttcggcgt cccgcccatc gacgtggccg cgtacgtggt
    14641 ggtccgcgtc tcgtccagca gcgccggccc ggccgccgcg agcagcggcg cgagcagccg
    14701 tcggccctcc tcggccgtcc cggcgtgcag gaccttgagc atgaccacgt gccgcccgcg
    14761 caccgccgcc ggcgtctgct cgtcgccggg catgcgcttg agcacgaccg cggtgctgat
    14821 ctcgtcgggg gcgtcgtcga tccacgtccg gtacgcctcc agcgtccgct ccgccacctc
    14881 gatcgggaag tagacgaacc cggcgaacac ctcggagacc gggtggagcc ggaactccag
    14941 cgaggtcacc acgccgaacc cggcaccgcc gccgcgcagc gcccagaaca gctcggggtg
    15001 gctgctcggg ctcgcggtca cgtgccggcc gtcggcgagc agcacctcgg cccgcagcac
    15061 gctgtcggcc gcgaacccgt gcttgcgggc cagccacccg agcccgccgc cgagggtgta
    15121 gccggtgacg ccgaccgacg gcgccgagcc ggacagcggc gccagcccga acggcgcggc
    15181 ggcggcgatc acgtcggccc agcgcgcgcc cggcccgacg tgggcgatcc ggcgctccgg
    15241 gtccaccagc accgacgcca tcgcggaggt cttgacgagg atgccgccgt cgcacggggc
    15301 gtgcgtgccg tggccggtgg actgcaccgc gaacggcagc ccgtgtgccc gcgccgccag
    15361 cagcgcgatc cgcaggtcgg cgacgctctg cgcctcggcg atcagcgccg ggcgggagtc
    15421 gacggccggg ttcagtgagc ggcgggcctc gtcgtagccg gcctcgcccg gcaggtgcac
    15481 ggtcccggtg aagccgggga ggcggaggtc ttcctggatg ctgctgtacg gctggctcat
    15541 cggtctggcc cttctggtct gctctgttcc tcgatctggg atcagagtgc tggagggcgc
    15601 ttacggtcgc gttcccgtcg ccttaccgcc gcccttaagg tctccaggat cttgccgccg
    15661 ggcctgcggc acatcggccg ccggtcgccg ctgcggctac gccgcccgtc gtacggggga
    15721 tgggcgcgta ctcccccgag aggaccttca aagttaggta aggctaatct aatatctcga
    15781 tcaccagctt ggctcagaag gagaccccat ggccgatgtc ccgcgacgcg ccctcgtcgc
    15841 cctcggtgcc gccgccctgc tcggcgtcag cgcctgcggc gggacggccg cgccgcccgc
    15901 gtcgtccgcg ccgcccgcgt cgtccgtcca gggcggctct tggacctggc aggacgaccg
    15961 cggaaagaag atcaccctgc cgcggcgccc ccagcgggtg gtggcccagt cggccgccgc
    16021 cgccgcgctg tgggacttcg gcgtgcggcc ggtcggcgta ttcggcccgc acaagctcaa
    16081 ggacggcggg cgcgatcccg aggtgggcga ggtcgacatc accaaggtgg agtcgatcgg
    16141 caacgtgtgg ggcgagttca acgtcgagaa gtacgccgcg ctccggcccg acctgctggt
    16201 ggccggcatg tacgtgaagg acacgctctg gtacgtcccc gagcagtccg tcgcggccgt
    16261 cgaccagatc gcccccaccg tcggcgtgca gctcagcggc aagcccctgg tgcagatcat
    16321 cgagaggtac ggccggctcg ccgaggcgct cggcgccgac ctcaccgcgg cgcccgtggc
    16381 tgaggccaag aagcgcttcg aggacgcgag cgccgccctc aagcggctcg ccgccgaccg
    16441 gcccggcctc agcgtcatgg tcgtcaccgg cacgcccgac tccctgtacg tggcctacct
    16501 gccggaccac cccgacctca agtactgggg cgaggacctc ggcctgaaga tcgtccaccc
    16561 ggaaaggccg accgagagcg agggcggctt ctgggaggtg ctgagctggg agaacgccga
    16621 caagtaccag gccgacgtga tcctcgtgga cgcccgcacc cagtccatga agatcgagga
    16681 gatggccgag aaacccacct gggccaagct gcccgccgtc aaggccggcc agctctaccc
    16741 gtggcacgcc gccgagcgct acagctacct cggctacgcc aaggtcatgg aggaactcac
    16801 gaccaacctg gacaaggcgc gcgacgacgt cgtcaaggag tgacgggcac gatctcggcc
    16861 ctgaccagca cgccctcctc gatcgtgagc agccccagcg tgccgcgcgg ctgacggcgc
    16921 cggtcggtgg gggagcccgg gttgaagatc cgcaggccgc cgccctcctc gtcgagcggg
    16981 atgtgcgagt gcccgaacac caccagctcc gcctccggga accggcgccg catccgcgcc
    17041 agccgcccct tggccgggcc gctgtcgtgg atcatgccga cccgcagccc gccgagcgtc
    17101 agctccagcg tctccggcgc caccacgtcc gggccgtcgt tgttgccctt cacgacgtgc
    17161 acgggcgcgt acgcggccag ctcgtccagc acgaagggca cgcagacgtc acccgcgtgc
    17221 aggatgacat cggcgccccg caggtgctcg gccacccggg gcgggcacgc gcgccagcgg
    17281 cggggcgcgt gcgtgtcgga gatcgcgacg acgttcaccc gaccctcatg ccccctcccg
    17341 cgctgccctc acatgatcag gacgggccga cgcgctgctc ggaggtggcg atgaccgctc
    17401 aggcgaccac cgccccgagg ctgctcttgg cggtggtgga cgagcgaccc ggcggccgat
    17461 ccccgtgcag ggagcctgcg gttatccggc gtacagctgc tccagccacg cccgccaccg
    17521 cgccccctgc tcctccccgc cctcgaacag caggtgcgag gcgatcatgg agccgccgaa
    17581 cccctggagg aaccggtaca tggccgtgcc ggagcgcagc ccgaccgtct gggagttgcg
    17641 gtggtagacg acgccctcga cgccgttgac cgcgacccgg tcgcccacct cgggcacccc
    17701 gccgatggcc gcgtacagac gctcccaagc cgccgcccag tccgcgaccg gcggcccgaa
    17761 ctccgtgacc ggcgtcgcgg cccgccccgc gaagtggccg aggtactcca cgagcgtcgc
    17821 gaagtacatc tccaggccct tggacatggc ctcgaactcg tcgtgccagt cgtcgcccgg
    17881 caggaacccg ctggtcacca tgcggacgag cgtgctgccc cgctcccggc cctcgatcat
    17941 gaactcgtag gcgacgaagc gcccgtcgtc gcccttgtcg ctggagtggg ccaggtgccg
    18001 gccgggctcg gcgtcggtga ccctggacgg cggcaggtcg aacccgccga acgcggtgcg
    18061 gacgaccccg ccggccacct cggtgcggcc catgaaccac gagtcgatgc ccggccccgt
    18121 cgagatggcc tcccagacct cctcgggggt ggctccgacg gtggcctcca tcggcagctc
    18181 gaagtcgcgg cccactgcta gcgctccttc actgaaggat ggaccgccac gaccagccgg
    18241 tggtcgcgcc caccctcggc ggactcgtca tgatatttgc tgaccagcga ggtgacgcac
    18301 tgtgccagct cctcggcgaa cgccgcccgg tccgccgccg acgcgaagcg cacctcgccg
    18361 tcgatggcga acgtcgccac ccgcttctgc gccttcgcgg agccggtgat gagggtgccg
    18421 acatcccgta cgagctgcgc ggccagcgcc agcagccacc gggcggacag gcggtcgggg
    18481 gagcgggccg ggtcgggctg cacggcggac agcgcggtgg gggagatgac gaacgaggcc
    18541 gccgtggccc gcatcacgcg ctcggtgacg ttgcccttct tgcgctcctc gaccagctcg
    18601 accaggccgt gccgctccag cgtgcgcagg tggtagttga ccttctgccg ggccaggccg
    18661 accttcgccg ccagcgaggt cgccgagccc ggctccacca gctcggccag gagcctcgac
    18721 cgcatggggt cgagcgacgc ctcggcggcc gcggcgtcct cgatcaccgc cacttcgtcc
    18781 atgggggaac gatggcaccg aaaaaaatcc ttgtcaagac aggcgggatg cccggtcctc
    18841 caggtaacgc cgctccggca ggctcgtcgt cagccgcgcc gcctcccggt aggccgccac
    18901 cgcgcccttc gcgtccccgt ccatctccag caggtgcgcc cgaaccgccg ccagccggtg
    18961 atgccccgcc atccggtcat cggcggccag ctcgtcgagc agactcagcc cggcacgcgg
    19021 cccgtgcacc atcgccgtgg ccaccgcctg attcagccgg acgaccggat tgtcctccac
    19081 gcccgcgagc accccgtaca acgccaggat ctgcggccag tccgtctccg cggcggtcgg
    19141 cgcctcgtcg tgcaccgccg cgatcgccgc ctgcaactgg tacggcccga ccgccgtcgt
    19201 ggacagcgcc ttcgtcacca gctccacgcc ctcctcgatc agccgccggt cccacagccc
    19261 gcgatcctgc tccgccagcg ggatcagccg cccctcgccg tcggtacggg cgggccggcg
    19321 cgcctcggtg agcagcatga gcgccagcag ccccatgatc tccccgtcgt cgggcagcag
    19381 ccgcgacacc gccctggtca gccggatcgc ctcccccgtc agctccgccc ggtgcagctc
    19441 gggccccgag gtggcggtgt acccctcgtt gaagatcaga tacagcacgt gcagcacgac
    19501 ccgcagccga tcctcccgct cgccctccgg cggcagcctg aactccgccc cgctggcctt
    19561 gatccgctgc ttggcccggc tgatccgctg ccccatcgtc gcctcgggca ccaggaacgc
    19621 gctcgcgatc tgcgccgtcg tcagcccgcc cacggcccgc aacgtcagcg cgagctgcga
    19681 cgcctccgac aacgacggat ggcagcacag gaacagcaac gtcagcgtgt catcccgatc
    19741 cccggcccga tcctcacccg gcgccggaac caccagctcg tcggccgccg cgctcaccgc
    19801 cacgctctcc tcgcggcgcc ggcgcgcgtg ctcactgcgt acatgatcga tgacccgccg
    19861 cgccgccacg gtcaccagcc agccgcgcgg gttgtccggc acgccgtccc gcggccactg
    19921 cacggaggcg tcgagcagcg cctcctgcac ggcgtcctcg cacatgtcga actgctcgta
    19981 acgccgtacg agcgtgccga gcacctgcgg cgccagctcc cgcaacagcc cctccacgct
    20041 gaccggcatc agcccgccac ctcgtcgagg accgtcgtgg ggatggcgcg gatcagcagc
    20101 atgtacgtca cgccccacat cctaggggtg caccgatccg gatatgaggg aaataccagc
    20161 tcagcggccc agtccgaggg ataacggggc agggcgggtc gaggcggggg ccggcggtgc
    20221 cgggagggtc gggcgtgcgc gcggtcgtag gcttcgtacc gtgcgaactc ccgatcttca
    20281 cgccatcgcc gcccggctgg ccgccgtgcc cggggtggtg gccgtcgccc tcggcggcag
    20341 ccgggcccgc ggcacccacc gtcccgacag cgacatcgac ctcggcctct actaccgggg
    20401 cgacctcgac gtcgccgggc tgcgcgcgct cgcccgggag gtgacgggcg aggaaacgga
    20461 cgtcaccgag cccggcggct ggggcccgtg ggtggacggt ggcggctggc tcacgatcga
    20521 cggatggcgg gtggactgga tctaccgcga cctcgaccgc gtgcaccgcg tctggcacga
    20581 ctgccgggcc ggccgctacg agatcggcgt ccaggccggc cacccgctgg gcttctactc
    20641 ccacgcctac gccggggagg tggcgttgtg ccaggtgctc gccgacccgg cgggcgagct
    20701 caccgcgttg cgcgaggcga ccgcccagta cccgccggcg ctgcgggacg cgctggtcgc
    20761 gggcttgtgg gagtccgact tcgccctgac gacggcccgg tacggcgccg ccgggaacga
    20821 tccggtgtac gtggccgggg cgctgttccg ggcgatcggc gtggcctgcc acgcgctgca
    20881 cgccgccgac ggggcctggc tgatcaacga gaagggcatg gtggccgccg ccggccggtt
    20941 gccgtcggcg ccggagacgt tcggggagcg ggcgcaggcg ctgctggcgg gcgtcgggag
    21001 cgcgcccgag gagatcaccc gcaccatcga caccgccgcc gagctgctcg ccgaggtacg
    21061 caccgcctgc ggtgcctgag cccgtcgcct cggaggcgct tccttgccgg ggagacatca
    21121 gatgtctgag gacctgataa gttgggcgca tgaccgtt
//
