LOCUS       NZ_CP017717            31614 bp    DNA     circular CON 03-MAR-2024
DEFINITION  [Actinomadura] parvosata subsp. kistnae strain ATCC 55076
            chromosome, complete genome.
ACCESSION   NZ_CP017717
VERSION     NZ_CP017717.1
KEYWORDS    RefSeq.
SOURCE      [Actinomadura] parvosata subsp. kistnae
  ORGANISM  [Actinomadura] parvosata subsp. kistnae
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Streptosporangiaceae; Nonomuraea.
REFERENCE   1  (bases 1 to 13047416)
  AUTHORS   Nazari,B., Forneris,C.C., Gibson,M.I., Moon,K., Schramma,K.R. and
            Setedsayamdost,M.R.
  TITLE     Nonomuraea sp. ATCC 55076 harbors the largest actinomycete
            chromosome to date and the kistamicin biosynthetic gene cluster
  JOURNAL   Medchemcomm (2017) In press
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 13047416)
  AUTHORS   Nazari,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2016) Chemistry, Princeton University, 20
            Washington Road, Princeton, NJ 08544, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 18-JUN-2015
            Assembly Method                   :: Celera Assembler v. Jun 2015
            Assembly Name                     :: SmrtPipe 1.87.139483
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 110.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/03/2024 13:15:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 12,000
            CDSs (total)                      :: 11,919
            Genes (coding)                    :: 11,783
            CDSs (with protein)               :: 11,783
            Genes (RNA)                       :: 81
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 136
            CDSs (without protein)            :: 136
            Pseudo Genes (ambiguous residues) :: 0 of 136
            Pseudo Genes (frameshifted)       :: 36 of 136
            Pseudo Genes (incomplete)         :: 98 of 136
            Pseudo Genes (internal stop)      :: 10 of 136
            Pseudo Genes (multiple problems)  :: 6 of 136
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:57:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1817712
            Orig. end                         :: 1849326
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP017717.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..31614
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /product="azole-containing-RiPP"
                     /region_number="7"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..31614
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="interleaved"
                     /product="RRE-containing"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..22094
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12094](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12094
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    884..898
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.35"
                     /tool="antismash"
     gene            complement(2055..3056)
                     /locus_tag="BKM31_RS64140"
                     /old_locus_tag="BKM31_08135"
     CDS             complement(2055..3056)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015431.4"
                     /locus_tag="BKM31_RS64140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08135"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_080037570.1"
                     /transl_table=11
                     /translation="MNDLEVRQLRYFVAVAEELHFGRAAERLGMAQPPLSRAIGRLERR
                     VGVRLLERTTRHVTLTPAGEVFLRDARIALDTIDAAVRRARHAGRPEPRLRLALKADHD
                     AGLLPRILSAYHSEDIAPVVELVHGARGEQAPALRDGRADVALVSGPFDDRGLDHEPLL
                     TEPRLVALAAGDPLAARPSLRLSDFAGRRLPSGALVEQSGLPSPHAGSGAGLDSDTGAG
                     AGLGAGTGAVAAATVPGQDAARRERVTTSRQGALDITQIFELVELGSIVWFLPASIARR
                     YPRPEIAYRAVEDLEPVTLSVAWPQEARSGAVACFVRKATEVAAAARSAPAS"
     protocluster    2087..31614
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[12086:21614](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      12087..21614
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="2"
     misc_feature    3211..3226
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.93"
                     /tool="antismash"
     gene            3286..4512
                     /locus_tag="BKM31_RS08175"
                     /old_locus_tag="BKM31_08140"
     CDS             3286..4512
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="BKM31_RS08175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08140"
                     /product="MFS transporter"
                     /protein_id="WP_230466053.1"
                     /transl_table=11
                     /translation="MKTDLSRGWRTHAAVLAFGTFAVGTDGFVVAGILPEIARSLDVSV
                     AAAGQLVTVFSIAYAVLAPVLATLTAGWSRRVVLPAGLALFAVGNVITALAPSYALVLV
                     SRAVAAGGASLYAATASATAAAIAGDERRGRAIAIVMLGLTSSLALGAPLGTAVGAALG
                     WRATMWLVTALALVVVPIIAVRLPDVGGGPAGGWRQRLAPLADRRVLGVLATTVVAFTG
                     IYVPYTYLSAVYEPATGGQGSRVAVLLLVFGVAGTVGNLLAGHFTDRTGPRRVVITGTL
                     LLTLVFLLVPALRGSYATAVAAIAVGGVFSFTVTTPQQHLIMSYAPPGTQPMAASLNQS
                     ALYLAVSLSGAAGGLALDAGGATLLPPLAAVFVAAAAVLTWLFGRADARRHDRADARRD
                     GRVTSEPRG"
     gene            4643..6697
                     /locus_tag="BKM31_RS08180"
                     /old_locus_tag="BKM31_08145"
     CDS             4643..6697
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017539.4"
                     /locus_tag="BKM31_RS08180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08145"
                     /product="NACHT domain-containing protein"
                     /protein_id="WP_080037571.1"
                     /transl_table=11
                     /translation="MGRIRLSTIVFGALALAASIIAAVLIVPLLRQAEVGDIDPLGATI
                     GLVSLAVSVPSLWLTWRGLRLQREEEAGAVADRLAGMVMTAESRTWSQLLGADESAMDV
                     AFELREAPARNAQGAGRTGTLDGVMDYFRGLRPRRLIITGAAGSGKTVLAVKLMIAMLR
                     ERRPGEAVPVRLSAASWDPRMSTDDFLTAHLVGNFHLSRPAAAKVVERRLVVPVIDGLD
                     EMDRSPSPEYASRAGHAIRALNDYRYADTKADVVVTCRSGHYEALAARDVRLRDAARVE
                     LRPLRPADIAAFLHDRADDPGRWRPVLDAVRAAPAGVLACGLRTPWRLTAAAVVYEQRD
                     PRGAYARDPAELLGPGLATEEAIRAHLVGWFVHAAVRSHPGHPGYTVRNVQRWLSALAG
                     HLDEAGGAAKSDLVLHELWPLAGPRSARIAGTAIAATIALAVVVASLAWMPEGFPFAAV
                     LAAVIPLITSSWSATQDAPSWVDVARLRTARGRREFAKGLLAGLLLALFGQSVNAVVHA
                     FWRHPDLALLEGWLLFGIPLGLVLGLMSVGTEQAPEPRGIVRSDLVIAPAGMLTIGLCA
                     FLLFLGSGLDGSTSFAFAFLTVSSVSFVATATGAPVGVVGLRYLGLLAATRRWNRRWLP
                     WRLGRFLAWCCGAGLMRQAGVSYQFRHRELQDHLADAGPTARERPSPSR"
     gene            complement(6663..7550)
                     /locus_tag="BKM31_RS08185"
                     /old_locus_tag="BKM31_08150"
     CDS             complement(6663..7550)
                     /GO_function="GO:0001216 - DNA-binding transcription
                     activator activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017626161.1"
                     /locus_tag="BKM31_RS08185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08150"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_230466054.1"
                     /transl_table=11
                     /translation="MMDLNTLRQFVVVARLEHLSRAADELRVAQPSLSRTISRLESELG
                     APLFERAGRLRLNETGRLFRDYVERSLGELDAGRRAVAEAVSEGVGGVRLASETFLTLT
                     GPLAAFKRAHPSIEVGLHWTPAEDMARRLRAQDVDLCVASQPIPVEGLESVRLFEDPVG
                     VGTPRDHRLAGRASVSVDELAGEPFITARKGHWIRRLLDRLFAARGLTPRIVCESDEPS
                     AIAQLISAGLGVGLVPGFARHSAAQTAGVWIPVDDPGCRRTVTLYWGADSHLSTAARLM
                     RATITGWDWAAPAP"
     gene            7660..8079
                     /locus_tag="BKM31_RS08190"
                     /old_locus_tag="BKM31_08155"
     CDS             7660..8079
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009082693.1"
                     /locus_tag="BKM31_RS08190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08155"
                     /product="hypothetical protein"
                     /protein_id="WP_080037572.1"
                     /transl_table=11
                     /translation="MATVADSLRSATSPAGWTLRAVVSAHAVAIAAQPVFAGVYLTGDY
                     DSLGRHALGADVVTSIGYVQVVVAIVIWVRLRRAWPFTGTLAIVAAETVQYFAGLDGAL
                     WLHLPLGVMTVAAVVVQFIAVWRRPLARRIEADHG"
     gene            8072..9847
                     /locus_tag="BKM31_RS08195"
                     /old_locus_tag="BKM31_08160"
     CDS             8072..9847
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012890851.1"
                     /locus_tag="BKM31_RS08195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08160"
                     /product="multicopper oxidase family protein"
                     /protein_id="WP_230466055.1"
                     /transl_table=11
                     /translation="MAERQEERGASTAGREEERGMSTARREEERGTSTAPRGMSRRRVL
                     GIGGALGLMAATALSTSAALARRPSVTGAELRSAVPLPPPYQVPLPIPATLEPVAPGRY
                     EIVQREASAEILPGVRTPLWTYGGTFPGPTIESRRGRQITVTHRNELPVPTVVHLHGGR
                     TPAASDGYPTDLVLPAGWTGTTAHAGHAAEPGHGTQAGHGAQAGHGTHGGHGMQAGHGM
                     QAGHGMKDARAVVTELTRDYTFPLDQRPTLLWYHDHRMDFTAPAIWRGLAGLHIVRDDA
                     EEALGLPAGPRELPLMIADRAFAADGSFLYPSLDPTLRERPGVQEPYLAGVLGDVILVN
                     GAPWPVHEVDAARYRLRVLNASNARHYELEAVTDDGRRLDLVQIGADQGLLAAPVTHRL
                     LPIAPAERYDVVIDFSGVPVGSRVRLLNRLGTGRTRDVMAFRVARKAADDSRVPGVLST
                     DLPAWRRSDAVRVRDFAFRAGQMHGGRGWLVGGLPFDPARADVTTGLGDVEVWRLVADV
                     HHPVHLHLVGFRVLSRSGRPPLPHDVGLKDTVSLRPGEAVEIITRFDGYRGRFLFHCHN
                     AEHEDMAMMANLEIV"
     misc_feature    complement(9871..9885)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 15.9"
                     /tool="antismash"
     misc_feature    9879..9893
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.6"
                     /tool="antismash"
     misc_feature    9885..9898
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.5"
                     /tool="antismash"
     misc_feature    complement(9940..9951)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.54"
                     /tool="antismash"
     misc_feature    complement(9971..9985)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 30.11"
                     /tool="antismash"
     misc_feature    9972..9986
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.15"
                     /tool="antismash"
     aSDomain        10001..10243
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BKM31_RS08200_Thiopeptide_F_RRE.1"
                     /evalue="1.10E-26"
                     /identifier="RREFam004.1"
                     /label="BKM31_RS08200"
                     /locus_tag="BKM31_RS08200"
                     /protein_end="81"
                     /protein_start="0"
                     /score="83.6"
                     /tool="antismash"
                     /translation="MRPQLRDDVRFVECPDGAYVHSDYGACTLRGRQAYAWLTRLAPAL
                     TGHHTLAELTASLPADRKTMVERLVGQLAEQRFVVD"
     gene            10001..12094
                     /locus_tag="BKM31_RS08200"
                     /old_locus_tag="BKM31_08165"
     CDS             10001..12094
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Heterocycloanthracin_C_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.4"
                     /locus_tag="BKM31_RS08200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08165"
                     /product="YcaO-like family protein"
                     /protein_id="WP_080037574.1"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 4.8e-24,
                     bitscore: 83.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     2.5e-11, bitscore: 42.7, seeds: 5, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPQLRDDVRFVECPDGAYVHSDYGACTLRGRQAYAWLTRLAPAL
                     TGHHTLAELTASLPADRKTMVERLVGQLAEQRFVVDARHPRPHGLTEAELRAYAEEIAF
                     IGYALDSPEERFQRIRHARLALVGEGPLLEALAAACVGSGWRHVTVITPAADQAGSGRS
                     GDRGGSERVRRVADAARRDPAQEVRTLPFSRDLRTIAGNADIVLQVGADLDELVATARA
                     CEAAGIMLGQALVRPAEVWIGPVGRPSETAAESGWHRLAGLPAATPAPPDEDLLTGPVP
                     TVVAAILALACFSRVTGLDTGSERELVRVDLRTLDTLPHRFLPHPRATTTRPQRVALEP
                     IRELTEELTALRAAAPAHATAPATPAQAAAPHPATSAMPAQAAPAVAEKAMAAVEADGL
                     LALTAELVDSRLGVLGMLDEQALTQSPVAVCQAVVSDPFGVLPGWAPARQAFGWGPDQR
                     TARLRCLLAALATYGVPALDHPDGEGVVWGVNLPDGRPRTVPTTALHLPSPPAQPAAEG
                     LAPVGAGAGLSWVEALAAGLRAHCEDLLRDRLSNAPQAATPTAPIDLPHDEEAEALLRQ
                     VALAGETPDIHDLTAVLGVPAVALTVPGQEAQVSVAATLRDALRDGLERLLLRWQSRAP
                     GQHVYARPHPLWPPDGDPAEAVRVMAGALRRSGKVPVAVPSHADPEVSRLLPFVVRIVL
                     LDD"
     aSDomain        10016..10273
                     /aSDomain="Heterocycloanthracin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing C protein in a
                     heterocycloanthracin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BKM31_RS08200_Heterocycloanthracin_C_
                     RRE.1"
                     /evalue="5.90E-14"
                     /identifier="RREFam011.1"
                     /label="BKM31_RS08200"
                     /locus_tag="BKM31_RS08200"
                     /protein_end="91"
                     /protein_start="5"
                     /score="42.7"
                     /tool="antismash"
                     /translation="RDDVRFVECPDGAYVHSDYGACTLRGRQAYAWLTRLAPALTGHHT
                     LAELTASLPADRKTMVERLVGQLAEQRFVVDARHPRPHGLT"
     gene            12087..14039
                     /locus_tag="BKM31_RS08205"
                     /old_locus_tag="BKM31_08170"
     CDS             12087..14039
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03604.1"
                     /locus_tag="BKM31_RS08205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08170"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_080037575.1"
                     /sec_met_domain="YcaO (E-value: 8.3e-67, bitscore: 225.7,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 7.8e-93, bitscore:
                     310.7, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEVVVAPAADPGLVTVLGEGRLHAAIRQALAAEPAGGAIVVASD
                     ADDVRPYPAVARRAAERAVPWLPVRVEAGWALVGPAVRPGRPGCPTCVARRRAGNRPDA
                     QARDALRAKWAADLDSRPTTLLTPLVSRTVAALVADEVRRLRRDPGSARTDGALLKVRL
                     PTGAVRRHTFLPDPLCPDCGTRTDDGPHAGRYVPRPAPKPDPGTFRVGGITGRGAELER
                     LFVDAETGIVQAVVAQERGGGPMAVARLSPSRTEHESHHGYGRSDDFASARATAVAEAL
                     ERIAGIHPRSRRTTVRAAYSDIAGHALDPRTLGLYPDDWYDQPGFLFTRFDPERPTTWV
                     WAYSFGRDAPVLVPESYAFFGPRPRDDLGFAYECSNGCALGGHPAEAVLYGLLEVAERD
                     AALATWYARLPVPRVDLGSAADRRIPMLAQRVRDRLGYDVHAFAALMEQRVPVFWVMAV
                     DALGGPGRPYALCGSASHLDPERALRRALEDLSPMLASHLERYDPATSARFVADSDQVR
                     LLEHHPLTYAHPDAFGRLAFLPLDGPALPLSEVTARTAWPRHDDLCADVAELAGRYLAT
                     GLDVIAVDITSPEARVCGMYAAKVLVPGTVSMTFGHRYRRVHGLPRLLTLPRLLGHRER
                     DLRPEDLNPYPHPFP"
     gene            14075..15925
                     /locus_tag="BKM31_RS08210"
                     /old_locus_tag="BKM31_08175"
     CDS             14075..15925
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013077.4"
                     /locus_tag="BKM31_RS08210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08175"
                     /product="SagB/ThcOx family dehydrogenase"
                     /protein_id="WP_155126718.1"
                     /sec_met_domain="PF00881 (E-value: 9.7e-06, bitscore: 25.2,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHTTTATSTATSAAPGAATSRYLAAMRNRGPLTIDWAAAPTRHKR
                     YPAAERVRLPWTGSGRGLLGELLRDLLGLTRIVWSHHLGDGGEPLGRPPMLLAGRPAPS
                     GGGLYPIEAYVAAREPHLPAALYHYDPVHHVLERVRGGDHVPALTGLLAGGPRADVVIV
                     LSAVFWRSMFKYGDFGYRLICQETGVLIAQALAVGERLGLAGGAHLRFADGQVDRLLGL
                     DSTREATLAALTLTLPPTNPHPPAPAPPLASQEQPTASSQPTTFPQPTASSQPTASAPP
                     PASQEQPAVSPQPITSRAPGPLPPSPDELMSRPTAGESRPLPQAMPSDGLAAALHRACA
                     LAFPDPPAPANGASPHAPAAARSSDRPAPPRPPVQATHPLPALRPAPRLTGAVARRASP
                     IAGYRPVPLPAGALGAVLAAACAGYPSDLPGTSAGPAATAVCVLSLRVDGLPRGAYWYD
                     PAGHTLHASATSIDAVTTGPLLPNTRVALRGAAAVLIPVGDPVAGAPTFGDRWYRMQQM
                     ETGLITQRAALAAAALGLAARIHSDGANETTDDVLGLARTPLRSLSFLVMGTPPTGGPL
                     VTRPIPAPVHEEVMDAPTTQRDPFDGFVPKENTEGDAHVR"
     gene            15915..16094
                     /locus_tag="BKM31_RS08215"
                     /old_locus_tag="BKM31_08180"
     CDS             15915..16094
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BKM31_RS08215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BKM31_08180"
                     /product="hypothetical protein"
                     /protein_id="WP_080037577.1"
                     /transl_table=11
                     /translation="MSAENLKLDLRGLEIDSIDVVSADSIVAEGHGTIETGASSSPGYC
                     SSYLTAMSCWAPEL"
     gene            16214..19087
                     /locus_tag="BKM31_RS08220"
                     /old_locus_tag="BKM31_08185"
     CDS             16214..19087
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="BKM31_RS08220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08185"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_155126721.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 5.6e-21, bitscore:
                     73.7, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQVAHVVPVAGDGDPVRLADPDYALSPVLAVRVAGLPVAGLERM
                     RCTRTWRLVDELTNVTSRLRREGAELSDPLHEVIGGVAAGPLRAGLVALRRAVFAGRRP
                     SGRAASAEVLAALPADLAARIGAWTTLRRRADELRAALPDVLAEETREKTAVLRAAVSD
                     AGFRHGLAQGSAVLAGRLEAWLAGPADRPPDRQELLRLARYLARASVKTSPYATFTLSG
                     LGRWDTDGPAVRTGGEPSWQLMAELDRAVLRPLWAVLTRHRRVRERARLRVNPSAADDG
                     DRIWFLSPGPGEPLSSVPATPQVRQALHWVRRHPDATLAAAPGIEPLAEAGLLEYVPPY
                     DEQGPDPLGELASWLAADGPAPYTLAVTRAAAALHASNGADASAALHASNGADASEAMC
                     GPDGANAPEPQPSPNGANVLELLQMEPGDGGKTTEAAPDGMAAAPGGIAAEPCGIAGTS
                     GGDPETAEIVRAALREVLPPGPSLPDKNLLWHSAVIPGVAGRLNATAWRGVCDDLDALR
                     GLLGLFDPDLPVKIAAAAYFLDRFGPTSRLHAMALYRDIHSGTPGAGSALLRAMLRDPV
                     AGTRALPDTDPPPGLRRLTELRRGFWERLGAGPIPSDVSTSDPMPGTASRVAVVDLTAA
                     RLADLAEGWPSFVRPPGSICCYVQAVPDPSGVRAVVNSVSAGYGRGLSRLHRLVTLAGG
                     EAPPVADLRAAQGEVMVAECRGLVGGGLNVRPATADVALDHPFTAPDSHLPPVTPAELT
                     VAYDREHDRLTLLDRAGRPVRPVHLGMTAQYWLPPWLQFLVRVFGEPSTAMVPGWVFRT
                     RGEPPAEGAVERWPRMDIGRVTVARAAWRLRAGAFPVPAKGESEAAYLPRLAEWLSRHG
                     MPRRFFARVVDLGQGLLAGLLSKDRKPMYVDVTDPLLLTGFVRTLRDPAALLVLEEALP
                     DPSQAPLYGTDARVTEYVIQLSTRPTS"
     gene            19084..20424
                     /locus_tag="BKM31_RS08225"
                     /old_locus_tag="BKM31_08190"
     CDS             19084..20424
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF025394.4"
                     /locus_tag="BKM31_RS08225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08190"
                     /product="lantibiotic dehydratase C-terminal
                     domain-containing protein"
                     /protein_id="WP_080037579.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.8e-39, bitscore:
                     134.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATPTHPSDAEHHRPDAAAAKPDARPRRPDAASDGARPHRPDGA
                     PGAVPPLRSGGAPDVARLDAENRWVSAHLFHFGDLDPLITGVVDPVTRELVADGTIRRA
                     FFLRYWEGGQHVRLRLEVPDPARQQCVRDLVRERAAAHFAGHPSPEVDPAAYRAFAAAM
                     ARGERRADYDERLHPPGTVAFIGYRPEYEAYGDAACVAAAERHFAVSSRLALDVLGAGT
                     DMGRRTAIGLAALTMAIAACEPDLPSAAHRLATATRAFDPPPTTHPPATDARAPVTPPI
                     GAVPFGTPAEAAPPGPMPGIRSEVVSSGTGPRTLAEAAFSGVTAAMEEDWRRREKALLA
                     QTRRLWDAPESAGGLLAAWASSLRALRDDLDALHAEGRCAPRDSGSPHALLALAAPPER
                     RTVSLILMRCVHLFHNRLGLRAGAEQHTTFLAGRAVAGLADPRRWSP"
     gene            20412..21614
                     /locus_tag="BKM31_RS08230"
                     /old_locus_tag="BKM31_08195"
     CDS             20412..21614
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF045556.1"
                     /locus_tag="BKM31_RS08230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08195"
                     /product="thiopeptide maturation pyridine synthase"
                     /protein_id="WP_186404973.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.1e-62, bitscore:
                     209.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVPLTRSPASEAPACSPAPDTPAWHCVHVYYHAPDKDALLLDAVR
                     PLLDGLRGEVAAAYVLRHWRQGPHLRINVKAAPAVWERVVRPRVDEVVGGYLREHPSRA
                     ALDPDESLPRHRLLAMREQERGPLTPWPPDNSIRDAPYDSRRHVLGTDEEADLLAAFYV
                     DANPLLFDMLEHVRAGRDGKTGLALSLMLTIAHTSQRIDRSYLSFRMHAEGYLTWAADP
                     GAARASFERTFRERRAALTRRVRDVVACLDDAGAPPVPFVREWAALLERYRPEIAAMME
                     DGRLVQPTIEPGEAFAARPGEPRAPQREPSELQRLVFDNPAYHEAIFSSPAFRRYRVLL
                     NYTYLHLTRLGLTPLDRFRTCHLLADAVEEVYGLSGLDSLRRFASAGAGATADGGTQPV
                     T"
     gene            complement(21733..22380)
                     /locus_tag="BKM31_RS08235"
                     /old_locus_tag="BKM31_08200"
     CDS             complement(21733..22380)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019349.4"
                     /locus_tag="BKM31_RS08235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08200"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_155126724.1"
                     /transl_table=11
                     /translation="MTQMLSERVHARLQEAIMRGEYAPGAALKPQELAQQHQVSLAVVR
                     EALVRLVGEGIAVRLPNRGFAVPHFSDRRWQEIAEARRTIEPAMLRLAIERGDLDWEAR
                     VRATHHRLARTPAYVPEEGEYYSSAWSEAHRVFHRTLLDGCGNPVLLDTFDRLWTASEL
                     ARRWSAQRTPERDGLAEHRRLEEVALARDADTAAEVLARHLTLTAAGLIACP"
     misc_feature    complement(22396..22410)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.57"
                     /tool="antismash"
     misc_feature    22397..22410
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.7"
                     /tool="antismash"
     misc_feature    22397..22411
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.87"
                     /tool="antismash"
     misc_feature    22412..22425
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.31"
                     /tool="antismash"
     gene            22482..23063
                     /locus_tag="BKM31_RS08240"
                     /old_locus_tag="BKM31_08205"
     CDS             22482..23063
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017589061.1"
                     /locus_tag="BKM31_RS08240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08205"
                     /product="YbhB/YbcL family Raf kinase inhibitor-like
                     protein"
                     /protein_id="WP_080037581.1"
                     /transl_table=11
                     /translation="MSLNNPFARLPEVPSFTVTSATLADGEPWPAAQLSAALPGGGDVS
                     PHLSWSGAPEGTKSYAVTVYDPDAPTGSGFWHWAVADIPAGVTELPEGAGDDTGSGLPA
                     GAYQLPNDARLPRYIGAAPPAGHGPHRYFVVVHALDVEHIGVPADATPAYLGFTISGHV
                     LARAVLTATAETAPAETAPAEAATATAGAS"
     gene            23060..23464
                     /locus_tag="BKM31_RS08245"
                     /old_locus_tag="BKM31_08210"
     CDS             23060..23464
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020543090.1"
                     /locus_tag="BKM31_RS08245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08210"
                     /product="cupin"
                     /protein_id="WP_080037582.1"
                     /transl_table=11
                     /translation="MTVTPIELFDAGIHLRQGGRIHAGKAPMDPGRDGWQLTAFHAKTG
                     ADVHADHWQVNTEAEEVVSCIIGKIRLYLCPERPGGQEEEIRLTAGTAAIVPRGRWRRI
                     QLDIPSTIMTITLTGGARLEERAGRSAKDR"
     gene            23504..24238
                     /locus_tag="BKM31_RS08250"
                     /old_locus_tag="BKM31_08215"
     CDS             23504..24238
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017625503.1"
                     /locus_tag="BKM31_RS08250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08215"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_080037583.1"
                     /transl_table=11
                     /translation="MARRTKAGTPAPEGPAGGRELTRQRVIEAAADLLAREGREAVTTR
                     AVAAAAGVQPPAIYRHFDDMDGLLDAVAEHGYARFLEAKRAFPTPEDPVEDLRAGWDLA
                     VEFGLANPALYAMMYGEPRRGTSSAAFRTGMEILHGRIRRLAAAGRLRVDEQLAAALIH
                     ATARGAVLTWLSLPADRRDPALLSTMRESMVTAVTTERPAVREPGPAGAARALRAALPQ
                     QTVLSEAEQRLLGEWLDRLAAG"
     gene            complement(24343..25200)
                     /locus_tag="BKM31_RS08255"
                     /old_locus_tag="BKM31_08220"
     CDS             complement(24343..25200)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009078843.1"
                     /locus_tag="BKM31_RS08255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08220"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_080037584.1"
                     /transl_table=11
                     /translation="MIIVTGATGQLGRQIVERLLTRVPADRIGVSVRDPGKARAFADQG
                     VRVRRGDFADPATLAHAFEGATQVLVVSIDRFGADAVGQHRAAIDAAVAAGARRVLYTS
                     HMGASASSHFQACRDHAATEEALRGCGVPYTALRNGFYAASALRFFDQGRHGDQLALPA
                     DGPVSWTFHEDLAEAAAAVLADEGRFDGPTPPLTAGRAFTFDDLARVAGEVTGRAVTRV
                     AVPDDRFQEQLTEHGVPAEYARHLIDIFLAARAGEFAAVDPALGTLLGREPISLESALR
                     KHLT"
     misc_feature    complement(25260..25276)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.32"
                     /tool="antismash"
     gene            complement(25271..26077)
                     /locus_tag="BKM31_RS08260"
                     /old_locus_tag="BKM31_08225"
     CDS             complement(25271..26077)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /GO_process="GO:0055072 - obsolete iron ion homeostasis
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1200: vibriobactin
                     utilization protein ViuB"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017544465.1"
                     /locus_tag="BKM31_RS08260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08225"
                     /product="siderophore-interacting protein"
                     /protein_id="WP_080037585.1"
                     /transl_table=11
                     /translation="MLPKVRMPESRHMITLEVVRNTRLSPHFTTVTLGGPQLERLRPTG
                     FDQTVRLFFPRDGQPGLTMPTLSNEAWMAQVLLQPKSRRPWVRNYTIRRARPEANEVDI
                     EFALHGDESPASAWAQRARPGDPAGIFDMGISYLPPAGAAWHLLAGDESALPAILAILD
                     SAPASLVAEVFLEVPSSADIRTDVTAPEGVRIHWLARDGSGATPGALALETVKRASLPE
                     GRFYTWVAGESRLATGLRRHLVTERGAAKGDVAFFGYWRHGRAISM"
     gene            complement(26091..26999)
                     /locus_tag="BKM31_RS08265"
                     /old_locus_tag="BKM31_08230"
     CDS             complement(26091..26999)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1094: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF012339.4"
                     /locus_tag="BKM31_RS08265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08230"
                     /product="PDR/VanB family oxidoreductase"
                     /protein_id="WP_080037586.1"
                     /transl_table=11
                     /translation="MQLTILDRIDRPAEDVVALTLRGAHGPLAPWEPGAHVDLALPNWL
                     TRQYSLCGDPRDRERYRIAVRHERLSRGGSDYIHRYLRPGRTLEVSLPRNTFPLVPAPS
                     YLFLAGGIGITAILPMLRAAADAGASCSLVYAGHTYASMPFAGELRAAYGDRVTVVATG
                     HDGRPDLAALAAGLAPETVVYCCGPTSLLDACEAVFPAERLHVERFRPRPRTFAPDTAF
                     DVVCARSGRTVPVPAGESLLNALTHAGLPVPAGCREGVCGSCEVTVLEGEPEHRDDVGA
                     APGRMYACVSRSRSARLVLDL"
     misc_feature    complement(26995..27008)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.87"
                     /tool="antismash"
     gene            complement(27015..27659)
                     /locus_tag="BKM31_RS08270"
                     /old_locus_tag="BKM31_08235"
     CDS             complement(27015..27659)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_process="GO:0008150 - biological_process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04025.1"
                     /locus_tag="BKM31_RS08270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08235"
                     /product="MSMEG_1061 family FMN-dependent PPOX-type
                     flavoprotein"
                     /protein_id="WP_080037587.1"
                     /transl_table=11
                     /translation="MTRQNAPLIERRPRRVSIEQVRDRLGEPDAMIKSKIQDHIDEHSR
                     RFIAHSPFLTMATADASGRADCSPRGDYPGFVKVLGEHLLAIPDRPGNRIADSFRNLAE
                     NDGIGLLFFVPGSRETLRVNGRAYATDEPDVLVRMQTEAREPELAIAVEVEEVYFHCGR
                     ALIRSRLWDPASQALADELPSLGEVAAAQFGMDIDPRLLEARLEEGYRQLY"
     gene            27730..28344
                     /locus_tag="BKM31_RS08275"
                     /old_locus_tag="BKM31_08240"
     CDS             27730..28344
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017544463.1"
                     /locus_tag="BKM31_RS08275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08240"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_080037588.1"
                     /transl_table=11
                     /translation="MSRDPRLHPRKQPRQVRAELTRRRILEAAAQVFTEYGYAAGTTNR
                     IAEYAGVSIGSLYQYYPNKDAILLELMLAHLDSGEEEATRRQTGELPGTAEGLMRLFVQ
                     AAIANHLEDPRLLRVMVEQAPRSPELLQRVYQFKNERNAHTRDLLRRYREVRVSDLETA
                     ARIINATIELVVHQVVAEHEPIDLQRLEDELVAMFTRYLTA"
     gene            complement(28355..29605)
                     /locus_tag="BKM31_RS08280"
                     /old_locus_tag="BKM31_08245"
     CDS             complement(28355..29605)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012892715.1"
                     /locus_tag="BKM31_RS08280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08245"
                     /product="cytochrome P450"
                     /protein_id="WP_230466056.1"
                     /sec_met_domain="p450 (E-value: 6e-26, bitscore: 90.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDDSLTEQPAGVSTATMRRILPADLVERGRDPFSPPPGLRGHGP
                     VREVELLNGARAWLVTGFDEARTVLADPRFSADKLRHRDATSLRPPQAPPEGERTDGAF
                     VFMDPPEHTRLRRVLTGQFTVRRMRELETRVRQIAVEHVEAMQAAGTRTADLVPAFALP
                     LPSLVICELLGVPYADRAEFQERTAVGLSASATMREQAAARAGLHAFMARLVAAKRANP
                     AGDLLSGLVHDADPPLTDAQLVDVALLLLTAGHETTANMLGLGTFALLEHPDQLAALRA
                     EPELIGDAVEELLRFLSIIQLGVSRVAKEPVTLGGVDLPAGATVVIATPEVNRDPRHWP
                     DPDMLDLRRPRTPHLAFGHGVHQCLGQQLARIELRIGLGELITRLPGLRLAVPAAQVPV
                     RDEMLIFGVHSLPVTWA"
     misc_feature    complement(29605..29623)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.18"
                     /tool="antismash"
     gene            complement(29688..30605)
                     /locus_tag="BKM31_RS08285"
                     /old_locus_tag="BKM31_08250"
     CDS             complement(29688..30605)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017583168.1"
                     /locus_tag="BKM31_RS08285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08250"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_080037589.1"
                     /transl_table=11
                     /translation="MDAVSELLAEVRARGAVFRRAVIRPPWALRMASGAPLTLATMLRG
                     HAWVVADGHEPVRLAAGDIAVVRGDAPYTVADDPATAPALEVTAADYCPGAGGVERAAT
                     LTCDAPGDEGAVLVSGTFERRGELSERLLRALPPVLVVPAEAGPFPSAGVVAEEIARDR
                     PGQQLVLDRLLDLMLVSALRAWFASRDASVPGWCRALDDPVAGAALRLLHDAPAHPWTV
                     AELAAKAGVSRAALARRFTALVGEPPMAYLAGWRVALAADLLRETDLTVAAIARRVGYA
                     NAFALSVAFKRLRGVRPTDHRRAV"
     misc_feature    complement(30652..30666)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.58"
                     /tool="antismash"
     gene            30688..31533
                     /locus_tag="BKM31_RS08290"
                     /old_locus_tag="BKM31_08255"
     CDS             30688..31533
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017622682.1"
                     /locus_tag="BKM31_RS08290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_08255"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_080037590.1"
                     /transl_table=11
                     /translation="MSEQPILVTGATGKTGRRVVRRLRAQGLPVRAAARGGEHAFDWAD
                     PGTWDAALRGVRAAYIVQVDGTKLVRPFVERAARHGVRRVVLASGRGIDLPGYANDRDG
                     VLEGLLDSEAAVRESGLEWTITRPGWFAQNFSEGFFADAVRAGELRLPAGDGAASFVDA
                     EDIAAVVAAALTGDGHAGQVYELSGPEAVTLTEAAATISEATGRKLRYVPISPREYVAE
                     LVQQGWPAADAAAFADVIEPLRNGTDAYVSDGVPRALGRPARTFAAFAKATAAEGGWPA
                     "
ORIGIN
        1 agcttggcgg cggtgacggt cagcggctcc tcgtccacct tcgggccgcc gtaggtggag
       61 gccgccacgt accgccactg gacggcctgg tagcgggagg ccagcgaggc ggccgtctcc
      121 gccgacagcg gctgggtgta ctccagctcg aagccgccct ccacggcgcg catcttgagg
      181 atgtcgaacg ccttgccgtc gcccggcgtc agcttctgca ggccgtaggt gagcttgccc
      241 ggctggcccc agttcccgcc ggcgcccagc ccgcccgcgt agatggcgcc gtcggggccg
      301 aggctgatcc ggttgacccc cgcctccagc ccctgcgtga agcggaagac cgcaccctgg
      361 tactcgccgc cgaccttctc caggtacgcg cgctggatcc cgccgtacgt gacgtcgccg
      421 aacagcacct gccccgcgaa cctgccccgc ttcagcacca ccgggttgct cggcgagttg
      481 gcgatctcgt tgtgcggcag ccacagcacc ggcgcgctca ccggctgctc ctcgaacggc
      541 ccgtcggggt tggtgtagtg gttgaagaag cggtccttct tgatgtggac gagcttcgag
      601 gccggcagcc agccgccctg gttgtcggtg acgaacagct caccctcggg gccccagccg
      661 atgccgttcg gcgtgcgcag gccgccggcc aggtactcga ccttgccggt ggccttgctg
      721 accttgatgg tggtgcccct gtcgcgcacg ggctgcgggt cggtggtggc gccgccgaag
      781 tcgatggcga cggacaggtt gatgtagaag tggccgtccc ggtagagcat gccgaacgcg
      841 aactcgtgga agttcccccc gaacggccag gtcgccacgg tacggaggtc gtcggccacc
      901 tcgtccccgt tggtgtcgtt cagctccacc aggcgggact tctccgagac gtacagcttg
      961 ccgtccacgt acttgatgcc catgggctcc tgcagcccgc tcgcgatccg cttggtcgtc
     1021 acccgctccg gcgacgtcgc gcccgtgacg ttgccgagca ggtagacctc gccgagccgg
     1081 ttctcggagc cgccccacgt cgcgatcgcc agccggccgt ccggcagcca gtccatcgcg
     1141 ctcacctgcg gctcgaaccc ggccgggcgc aggtcggtga gtgtcaggtc aggatgtacg
     1201 gactgcagcg gcagcccgtc gcccggcgag tcggcgccgc tctcgcactc cttgcggccg
     1261 ggggcggtga cccgcaccac gtccgcgtcc gtgctgagca ccgaggtcgg caccagggcg
     1321 aagtcggcgg cgccgggcgg cttccactcc agcttgagct gctggccgta caggtgctcg
     1381 aagtggtcga cgcgcagcgc gtggtagccc ggggtgagcg tgatcgtgcc gtcgatggcg
     1441 atcgggccgt gccggccgtc gttcgtgacc acgacggtgt cgtcgatgcg caggcgggag
     1501 ccgtcgtcgc tggtgaggcg gaactcgtac gtgccggccg ccgcgatgtt gatgttgccg
     1561 acgacctcgg tgacgaacat gtcggtcagg ccgaagtcgg cgtcggaggt ccagtcgatc
     1621 gtgggcatca gcttgtccac gttcggggtc tggccgggct tgagcgtgca gagcttggac
     1681 agctccacct ggacgtcgta cgtgcgcagg gtgacgccgg gctcctgcgg ggggacctcg
     1741 gcgtgcgcgg gggcggggac gaccaggcag gtgaggagga gcgctaagag ggataacagg
     1801 gggattttcc gcatgaccta tcccatctcg gaggggggtg ccgcgtttgc cggcgcgggc
     1861 ggccgtgtcg gcggatgctg gggggtcatc cgctgggagg tgaagggaat tacgctgctc
     1921 tgcgccgtaa tataagacga gatcttcgcc ttgcccatag gcttccgccg aaaatcgatg
     1981 aaagtcgtga tatgtcgggg cggaaggggc gcgcgggcgc gcgcaggggt gcgggggcgg
     2041 gcggcctacg caggctaaga ggcgggtgct gagcgggcgg cggccgcgac ttccgtggcc
     2101 ttgcggacga agcaggcgac ggctcccgaa cgggcctcct gcggccaggc gaccgacagc
     2161 gtgaccggct ccaggtcctc cacggcccgg taggcgatct cgggccgcgg gtagcggcgc
     2221 gcgatcgagg cgggcaggaa ccagacgatc gagcccagct ccaccagctc gaagatctgc
     2281 gtgatgtcca gggcgccctg ccgggaggtg gtgacgcgct cgcgccgggc cgcgtcctga
     2341 ccggggacgg tggcggcggc gaccgcgccc gtgccggcgc ccaagccggc gcccgcgccg
     2401 gtgtccgagt cgagcccggc gcccgagccg gcgtgcgggg acgggagccc cgactgctcg
     2461 acgagcgcgc cgctgggcag ccggcggccg gcgaagtcgg acagccgcag gctggggcgg
     2521 gcggcgagcg ggtcgccggc cgcgagcgcg acgaggcggg gctcggtcag cagcggctcg
     2581 tggtccaggc cgcggtcgtc gaacgggccg ctcacgagcg cgacgtcggc ccgcccgtcg
     2641 cgcagcgccg gagcctgctc gccccgcgcc ccgtgcacca gctccaccac gggcgcgatg
     2701 tcctcgctgt ggtaggcgga caggatgcgg ggcagcagcc cggcgtcgtg gtcggccttg
     2761 agcgcgagcc gaaggcgagg ctcgggccgg cccgcgtgcc gggcgcgccg gacggcggcg
     2821 tcgatcgtgt cgagggcgat gcgggcgtcg cgcaggaaga cctctcccgc cggggtgagc
     2881 gtgacgtgac gggtggtgcg ttccagcagc cgcacgccga cgcggcgctc cagccggccg
     2941 atcgcgcgcg acagcggggg ctgcgccatg cccagccgct cggccgcccg cccgaagtgc
     3001 agctcctccg cgaccgccac gaagtatctg agctgccgca cctccagatc attcatctcc
     3061 gcaaggctat caatactgat ccgatcgatc cttcaggtcc tccccggtga gcggttgact
     3121 ggaccccgcg gccccatcgc cgggccgccg acccccgtga tcccgcaccg gggtccttcc
     3181 tgtcttgaat ccgtccgtca tggagacatt catgatcgtc aatatcgtgc ccgcctgccc
     3241 gggcgccccc gtacgcaccc ctcagtccgg cgggcgggag ggcaggtgaa gaccgacctc
     3301 agccggggct ggcgcacgca cgcggcggtc ctcgcgttcg ggacgttcgc cgtcggtacg
     3361 gacggcttcg tcgtcgccgg catcctgccc gagatcgccc ggtccctcga cgtcagcgtg
     3421 gccgcggcgg gccagctcgt caccgtcttt tccatcgcct acgccgtgct ggccccggtg
     3481 ctcgccaccc tgaccgccgg ctggtcgcgg cgcgtcgtgc tgcccgccgg gctggcgctg
     3541 ttcgccgtgg gcaacgtgat cacggcgctg gcgccctcgt acgcgctggt gctggtgtcg
     3601 cgggcggtcg ccgcgggcgg ggcgtcgctc tacgcggcga cggccagcgc cacggcggcg
     3661 gcgatcgccg gggacgagcg ccgcggccgg gccatcgcga tcgtcatgct cggcctcacg
     3721 tcgtcgctcg cgctgggcgc cccgctcggt acggcggtgg gggcggcgct cggctggcgg
     3781 gccacgatgt ggctggtcac ggccctggcc ctggtcgtgg tgccgatcat cgcggtccgc
     3841 ctgcccgacg tgggcggcgg cccggccggc ggctggcggc agcggctcgc cccgctcgcc
     3901 gaccggcggg tgctcggcgt gctcgccacc acggtcgtcg cgttcaccgg catctacgtg
     3961 ccgtacacgt acctgagcgc cgtgtacgag cccgccaccg gcggccaggg cagccgcgtg
     4021 gcggtgctgc tgctggtgtt cggggtggcc ggcaccgtgg ggaacctgct ggcggggcac
     4081 ttcaccgacc gcaccggccc gcgccgcgtc gtgatcaccg gcacgctgct cctcaccctc
     4141 gtcttcctgc tggtgccggc gctgcgcggc tcgtacgcga cggcggtggc ggccatcgcg
     4201 gtcggcggtg tgttctcctt caccgtcacc acgccgcagc agcacctgat catgagctac
     4261 gccccgccgg gcacgcagcc catggccgcc tccctgaacc agtccgccct ctacctggcg
     4321 gtctcgctgt cgggcgcggc cggcgggctc gccctcgacg ccggcggagc cacgctcctc
     4381 ccgccccttg cggccgtgtt cgtcgccgcc gcggccgtcc tcacgtggct gttcggccgg
     4441 gcggacgcac ggaggcacga ccgggcggac gcccggaggg acggccgggt gacctcggag
     4501 ccgcgagggt gacctccgcc gtcgcctccg ccggcagcgg acgatgaggc ggccgggcta
     4561 gggacatccc cggcccacca cctgaggcgc cgcccgcgcc cgggggtcta cggtgcgggg
     4621 acccgtacag gcaggggagc gcatgggccg gatcaggctg tccacgatcg tcttcggcgc
     4681 gctcgccctg gccgcctcga tcatcgcggc ggtcctgatc gtcccgctgc tgcgtcaggc
     4741 ggaggtcggc gacatcgatc cgctcggcgc gacgatcggg ctggtgtcgc tggcggtgag
     4801 cgtcccgtcc ctgtggctga cctggcgcgg cctgcgcctg caacgggagg aggaggcggg
     4861 cgcggtcgcg gaccggctgg cgggcatggt gatgacggcc gagtccagga cgtggagcca
     4921 gctgctcggg gcggacgaga gcgcgatgga cgtcgcgttc gagctgcggg aggcgcccgc
     4981 gcgcaacgcc cagggcgccg gccgcacagg cacgctggac ggggtgatgg actacttccg
     5041 gggcctgcgc ccccggcggc tgatcatcac cggcgccgcc ggctcgggca agacggtgct
     5101 ggcggtgaag ctgatgatcg ccatgctcag ggagcgccgc ccgggcgagg cggtgcccgt
     5161 acggctgtcc gccgcctcct gggacccccg gatgagcacg gacgacttcc tgaccgccca
     5221 cctcgtcggg aacttccacc tgtcccgccc cgccgccgcc aaggtcgtcg agcgccgact
     5281 ggtcgtgccg gtgatcgacg gcctggacga gatggaccgg agcccgtccc ccgagtacgc
     5341 ctcccgcgcc ggccacgcca tccgcgcact gaacgactac cgctacgccg acacgaaggc
     5401 cgacgtcgtc gtgacctgcc gctccggcca ctacgaggcg ctggcggcgc gcgacgtgcg
     5461 gctcagggac gcggcccggg tggagctgcg cccgctgcga ccggcggaca tcgccgcgtt
     5521 cctgcacgac cgggcggacg atcccggccg ctggcgtccc gtcctggacg ccgtgcgcgc
     5581 cgcgcccgcc ggcgtcctgg cgtgcggcct gcgcacgccg tggcggctca ccgcggccgc
     5641 ggtcgtgtac gagcagcgcg acccgcgcgg cgcctacgcc cgcgaccccg ccgaactgct
     5701 cggccccgga ctcgcgacgg aggaggcgat ccgcgcgcac ctggtcggct ggttcgtgca
     5761 cgcggccgtg cgctcgcatc ccgggcatcc cgggtacacg gtgcgcaacg tccaaaggtg
     5821 gctctcggcc ctggccggtc acctggacga ggccggggga gcggcgaagt cggacctcgt
     5881 cctgcacgag ctgtggccgc tggcgggacc gcgcagcgcg cggatcgccg gcacggccat
     5941 cgcggccacg atcgcgctgg ccgtggtcgt ggcgtcgctg gcctggatgc cggagggctt
     6001 tccgttcgcg gccgtgctgg cggcggtgat ccccttgatc acctccagct ggagcgcgac
     6061 ccaggacgcc ccgagctggg tcgacgtggc gcggctgcgc acggcgcgag ggcggcgcga
     6121 gttcgccaag gggctgctcg ccggcctgct gctcgcgttg ttcgggcagt cggtgaacgc
     6181 cgtcgtccac gccttctggc ggcaccccga cctggccctg ctggaggggt ggctgctctt
     6241 cgggatcccc ctgggcctgg tgctggggct catgtccgtc gggacggagc aggcgccgga
     6301 gccgcgcggc atcgtccgct ctgacctcgt gatcgccccc gcgggcatgc tcaccatcgg
     6361 gctctgcgcc ttcctgctct tcctcggatc gggcctggac gggagcacca gtttcgcgtt
     6421 cgcgttcctg accgtgtcgt ccgtgtcgtt cgtcgccacc gccaccggcg cgcccgtcgg
     6481 cgtcgtcggg ctgcgttacc tggggctgct cgccgccacc cggcgctgga acaggcggtg
     6541 gctgccgtgg cggctcggcc ggttcctggc gtggtgctgc ggcgccgggc tgatgcggca
     6601 ggcgggcgtc tcctaccagt tccgccaccg cgagcttcag gaccacctgg cggacgccgg
     6661 gcctacggcg cgggagcggc ccagtcccag ccggtgatgg tggcgcgcat cagccgggcc
     6721 gccgtggaca ggtggctgtc ggccccccag tacagggtca ccgtgcggcg gcagccggga
     6781 tcgtcgacgg ggatccagac gccggcggtc tgcgcggcac tgtggcgggc gaacccgggc
     6841 accaggccga ccccgagccc cgcgctgatc agctgcgcga tcgcgctggg ctcgtcgctc
     6901 tcgcacacga tccgcggcgt gagcccgcgc gcggcgaaga ggcggtcgag cagccgccgg
     6961 atccagtgcc ctttgcgggc ggtgatgaac ggctcgccgg ccagctcgtc gacgctcacg
     7021 gacgcccggc ccgccagccg gtgatcgcgc ggcgtgccca cccccacggg atcctcgaac
     7081 agccgcaccg actccaggcc ctccacgggg atcggctgcg aggccacgca caggtcgacg
     7141 tcctgggcgc gcaggcggcg cgccatgtcc tcggccgggg tccagtgcag gccgacctcg
     7201 atgctggggt gcgcgcgctt gaaggccgcc agcggccccg tgagcgtgag gaacgtctcc
     7261 gacgccagcc gcaccccgcc caccccctcg ctgacggcct ccgccaccgc cctccgcccg
     7321 gcgtcgagct cgccgagcga acgctcgacg tagtcgcgga agagccggcc cgtctcgttc
     7381 agccggagcc ggcccgcccg ctcgaacagc ggcgcgccca gctcgctctc caaccggctg
     7441 atggtgcggc tcagcgacgg ctgggcgacg cgcagctcgt cggcggcgcg gctcaggtgc
     7501 tcaagccgcg cgacgaccac gaactgccgg agcgtgttca ggtccatcat gcctcccgcg
     7561 acataacgtc atagcgatat tgatcttaga caggataact ccgggatcat atcgtcgagc
     7621 gtgctcgaca agcgagacca gagtttgagg aggctcctga tggccaccgt ggccgacagc
     7681 ctgagatccg ccacgtcccc cgcgggatgg acactgcggg ccgtcgtcag cgcgcacgcc
     7741 gtcgcgatcg ccgcgcagcc ggtgttcgcc ggcgtgtacc tgacgggtga ctacgacagc
     7801 ctgggccggc acgcgctcgg cgccgacgtc gtcacctcca tcggctacgt acaggtcgtc
     7861 gtggcgattg tgatctgggt acggctgcgc cgcgcgtggc cgttcaccgg caccctcgcg
     7921 atcgtggcgg ccgagaccgt gcagtacttc gccgggctgg acggggcgct gtggctgcac
     7981 ctcccgctcg gcgtgatgac cgtcgcggcg gtggtcgtgc agttcatcgc cgtctggcgc
     8041 cggcccctcg cgcgccggat cgaggccgat catggctgag cgccaggagg agcgcggggc
     8101 gagcacggcg ggacgcgagg aggagcgcgg gatgagcacg gcgcggcgcg aggaggaacg
     8161 cgggacgagc acggccccgc gtggaatgag ccggcggcgg gtgctgggga tcggcggggc
     8221 gctcgggctg atggcggcca ccgccctgtc cacctcggcg gcgctggccc ggcggccgtc
     8281 ggtcaccggc gccgagctgc gcagcgccgt cccgctgccg cctccgtacc aggtgccgct
     8341 gccgatcccg gccacgctgg agccggtcgc ccccgggcgt tacgagatcg tccagcggga
     8401 ggcgagcgcg gagatcctgc ccggcgtcag gaccccgcta tggacgtacg gaggcacgtt
     8461 ccccggaccc acgatcgagt cgcgccgcgg tcggcagatc accgtcacgc accgcaacga
     8521 gctgcccgtc ccgacggtcg tgcacctgca cgggggacgc acgccggcgg cctccgacgg
     8581 ctaccccacc gacctcgtcc tgcccgcggg ctggacggga accaccgcac acgccggcca
     8641 cgccgccgag ccggggcacg gcacgcaagc gggtcacggt gcccaggcgg gtcacggcac
     8701 gcacggcggg cacggcatgc aggcgggtca cggtatgcag gcgggtcacg gcatgaagga
     8761 cgcgcgggcg gtggtgaccg agctgacccg cgactacacc ttccccctgg accagcggcc
     8821 caccctcctc tggtaccacg accaccggat ggacttcacc gcgcccgcga tctggcgcgg
     8881 cctggccggg ctgcacatcg tccgtgacga cgccgaggag gcgctcggcc tgcccgccgg
     8941 gccgcgcgag ctccccctca tgatcgccga ccgggccttc gccgccgacg gcagcttcct
     9001 gtacccgtcc ctcgacccga cgctgcggga acggccgggc gtgcaggagc cgtacctcgc
     9061 cggcgtcctg ggtgacgtga tcctggtgaa cggcgcgccg tggccggtgc acgaggtcga
     9121 cgcggcccgc taccggctgc gcgtcctgaa cgcctcgaac gcccgccact acgagctgga
     9181 agcggtcacc gacgacgggc gccggctgga cctcgtccag atcggcgccg accaggggct
     9241 gctcgccgcg ccggtcacgc accggctcct gccgatcgcg cccgccgagc gctacgacgt
     9301 ggtcatcgac ttctcgggcg ttccggtcgg gagccgggtc aggctgctca accggctggg
     9361 caccggccgc acccgtgacg tgatggcgtt ccgggtcgcg cgcaaggccg ccgacgacag
     9421 ccgcgtcccg ggcgtcctgt ccaccgatct gccggcatgg cggcggtccg acgccgtcag
     9481 ggtgcgggac ttcgccttcc gtgccgggca gatgcacggg gggcgtggct ggctggtggg
     9541 cgggctgccg ttcgacccgg cgcgggccga cgtcaccacc ggtctgggcg atgtggaggt
     9601 gtggcggctg gtcgccgacg tccaccatcc cgtgcacctg cacctggtcg gcttccgcgt
     9661 actctcgcgc agcggccggc cgccccttcc gcacgacgtc ggtctcaagg acacggtctc
     9721 cctgcgcccg ggcgaggctg tggagatcat cacgcgcttc gacggttacc ggggacgctt
     9781 cctcttccac tgccacaacg ccgagcacga ggacatggcc atgatggcca atctcgagat
     9841 cgtgtgactt tccggtaagt gacattccgt aatcgaaaat gagaaatggc gattataact
     9901 gccatcgggc gcacttaaaa ggggtgatat ggggtttaca taaacgcttt ccattcgtaa
     9961 tatcccactc atgggagcgc tcccaaaagc cgattcggcg atgagaccgc agcttaggga
    10021 cgacgtacgg ttcgtcgaat gccccgacgg cgcctacgtc cacagcgatt acggtgcgtg
    10081 caccctgcgg ggccggcagg cgtacgcctg gctcacccgg ctggcccccg ccctgaccgg
    10141 ccaccacacc ctcgccgagc tcaccgcgag cctccccgcc gaccgaaaga ccatggtcga
    10201 gcgcctggtg ggacagctcg ccgaacagcg cttcgtggtc gacgcccgcc acccccggcc
    10261 ccacgggctg acggaggcgg agctgcgcgc gtacgcggag gagatcgcct tcatcggcta
    10321 cgccctcgac tcgcccgagg aacgcttcca acgcatccgg cacgcccggc tggcgctggt
    10381 gggggagggg ccgctgctgg aggcgctggc ggcggcctgc gtcggctcag gctggcgcca
    10441 cgtcaccgtg atcacccccg ccgccgacca ggccggctcc gggcggtccg gtgatcgggg
    10501 cggctccgag cgggtccgcc gggtcgcgga tgcggcccgg cgcgatcccg cccaggaggt
    10561 ccggacactg cccttctccc gcgacctgcg gacgatcgcc gggaacgccg acatcgtgct
    10621 ccaggtgggc gcggacctcg acgagctggt ggcgacggcc cgagcctgcg aggccgccgg
    10681 gatcatgctg gggcaggcac tcgtccgccc ggcggaggtc tggatcggcc cggtggggcg
    10741 cccctcggag acggcggccg agtcgggctg gcaccggctc gccgggctgc ccgccgcgac
    10801 ccctgccccg cccgacgagg acctgctgac cgggccggtg cccacggtgg tcgccgccat
    10861 cctggcgctc gcctgcttca gccgcgtgac cggcctcgac accggctcgg aacgcgagct
    10921 cgtccgggtg gacctgcgca cgctcgacac cctcccgcac cgcttcctgc cccacccgcg
    10981 cgccaccacc acccgtcctc agcgggtcgc ccttgagccg atcagagagc tgacagagga
    11041 actgacagcc ctgcgcgcag cggcgcccgc ccacgcgaca gcgcccgcga cgcccgccca
    11101 ggcagcggcg cctcacccag cgacgtctgc gatgcccgcc caggcggcac ccgctgtggc
    11161 ggagaaggcg atggctgccg tcgaggcgga tgggctgctc gccctcaccg ccgagctggt
    11221 cgactcccgg ctgggcgtgc tcggaatgct cgacgagcaa gccctgacgc agtcgccggt
    11281 cgcggtgtgc caggcggtcg tctccgaccc gttcggtgtg ctgcccggct gggcgccggc
    11341 gcggcaggcg ttcggctggg gccccgatca acggacggcc cggctgcggt gcctgctcgc
    11401 cgccctcgcc acgtacggtg tgccggccct ggaccacccc gacggggagg gggtggtctg
    11461 gggcgtgaac ctgccggacg gccggccacg caccgtgccc accaccgccc tccacctccc
    11521 cagtcctcca gcccaaccgg ccgcggaggg gctggcgccg gtcggggccg gggccgggtt
    11581 gagctgggtg gaggcgttgg ccgctgggct gcgggcccac tgcgaggacc ttctgcgcga
    11641 tcgcctctcg aacgcacctc aggcggcgac gcccaccgcg ccgatcgacc tcccgcacga
    11701 cgaggaggcc gaggcgttgc tgcggcaggt ggccctggca ggcgagacgc cggacatcca
    11761 cgatctcacc gccgtcctcg gcgtccccgc cgtcgccctg acggtccccg gccaggaggc
    11821 gcaggtgtcc gtagccgcca ccctccgcga cgcgctgcgc gacggcttgg aacggctgct
    11881 gctccgctgg cagtccaggg ctcccggcca gcacgtttac gcacgacccc accccctgtg
    11941 gcctccggat ggcgacccgg ccgaggccgt ccgggtgatg gcaggggcgt tgcgccggtc
    12001 ggggaaggtg ccggtggcgg tgccgtcgca cgcggatccg gaggtgtccc ggttgctgcc
    12061 gttcgtcgtc cgaatcgtgc tgctcgatga ctgaggtcgt cgtcgcgccc gccgcggacc
    12121 ccggcctggt gaccgtcctg ggggaaggac gcctgcacgc ggcgatcagg caggcactgg
    12181 ccgccgagcc ggccggcggc gcgatcgtgg tggcgagcga cgccgacgac gtgcggccgt
    12241 acccggcggt ggccaggcgg gcggcggagc gggccgtgcc gtggctgccg gtgcgggtcg
    12301 aggcgggctg ggcgctggtc ggcccggccg tccgccccgg taggccgggc tgccccacgt
    12361 gcgtggcgcg caggcgggcc ggcaaccgcc cggacgcgca ggcccgcgac gccctgcgcg
    12421 cgaaatgggc cgccgacctc gactcccggc cgaccacgct gctcaccccg ctcgtgtcgc
    12481 gcacggtcgc cgcgctggtc gccgacgagg tgcgccggct gcgccgcgac cccggctccg
    12541 cgcgtaccga cggcgcgctg ctgaaggtcc gcctgccgac cggcgcggtg cgccggcaca
    12601 cgttcctgcc cgacccgctg tgccccgact gcggcacgcg aacggacgac gggccgcacg
    12661 ccggacggta cgtcccgcgc ccggcgccca agccggaccc cgggacgttc agggtcggcg
    12721 ggatcaccgg caggggagcg gagctggagc ggctcttcgt ggacgcggag accggcatcg
    12781 tccaggcggt cgtggcgcag gagcgcggcg gcggccccat ggcggtggcg cggctcagcc
    12841 cgtcccgcac ggagcacgag agccaccacg gctacggccg cagcgacgac ttcgcctccg
    12901 cccgcgccac cgccgtcgcc gaggcgctgg agcgcatcgc cggcatccat ccgcgcagcc
    12961 ggcggaccac cgtccgcgcc gcgtacagcg acatcgccgg ccacgcgctc gacccgcgca
    13021 cgctcggcct ctacccggac gactggtacg accagcccgg cttcctgttc acccggttcg
    13081 acccggaacg cccgacgacg tgggtgtggg cgtactcgtt cggccgggac gcgcccgtgc
    13141 tggtgccgga gagctacgcc ttcttcggcc cccgcccccg cgacgacctc ggcttcgcct
    13201 acgagtgctc caacggctgc gccctgggcg gccacccggc cgaggccgtc ctgtacgggc
    13261 tgctggaggt ggccgagcgg gacgcggccc tggccacctg gtacgcccgg ctgcccgtcc
    13321 cgcgcgtgga cctcggctcg gcggccgacc gccgcatccc gatgctcgcc cagcgggtac
    13381 gcgaccggct gggctacgac gtgcacgcgt tcgcggcgct gatggagcag cgggtgccgg
    13441 tgttctgggt gatggccgtg gacgcgctcg gcgggcccgg ccgcccgtac gcgctgtgcg
    13501 gctccgcctc gcacctcgac ccggagcggg cgctgcgccg cgcccttgag gacctgagcc
    13561 cgatgctggc cagccacctc gaacgctacg accccgccac gtccgcgcgg ttcgtggccg
    13621 actccgacca ggtgcggctg ctggagcacc accccctcac ctacgcgcat ccggacgcgt
    13681 tcggccggct ggccttcctg ccgctggacg ggcccgcgct gcccctgtcc gaagtgacgg
    13741 cccgcaccgc ctggccccgc cacgacgacc tctgcgcgga cgtggccgag ctggccggcc
    13801 gctacctggc caccggcctc gacgtgatcg ccgtcgacat cacctcgccc gaggcgcggg
    13861 tgtgcggcat gtacgcggcg aaggtcctcg tgccggggac ggtctccatg acgttcgggc
    13921 accgctaccg gcgcgtgcac ggcctgcccc ggctgctgac cctgccccgg ctcctcggcc
    13981 accgcgaacg cgacctgcgc cccgaggacc tgaacccgta cccgcacccg ttcccctgac
    14041 cggcccccac cgaaggaagc gaggcagagc ccgcgtgcac acgaccacgg ctacgagcac
    14101 ggctacgagt gcggcgcccg gcgcggcgac gagccgctac ctggccgcca tgcggaaccg
    14161 gggcccgctg accatcgact gggccgccgc cccgacccgc cacaagcgct acccggccgc
    14221 cgaacgcgtc cgcctcccct ggacagggtc cgggcgcggg ctgctgggcg agctgctgcg
    14281 ggacctgctc gggctgacgc ggatcgtctg gtcccatcac ctcggcgacg gtggcgagcc
    14341 tctgggacgt cccccgatgc tgctcgccgg ccggcccgca ccgtcgggcg gcggtctcta
    14401 cccgatcgag gcgtacgtgg ccgcgcgcga gccgcacctg cccgccgccc tgtaccacta
    14461 cgacccggtg caccacgtgc tggagcgcgt ccgcggcggc gaccacgtcc cggcgctgac
    14521 cggcctgctc gcgggcggcc ctcgggcgga cgtggtgatc gtgctgtccg cggtgttctg
    14581 gcggtcgatg ttcaagtacg gcgacttcgg ctaccgcctg atctgccagg agaccggggt
    14641 gctcattgcg caggcgctgg ccgtggggga gcggctgggg ctggccggcg gggcgcacct
    14701 gcggttcgcg gacggccagg tggaccggct gctcggcctc gacagcaccc gcgaagcgac
    14761 cctcgccgcc ctcaccctca ccctcccgcc cacgaacccc caccccccgg cccccgcacc
    14821 gccccttgcc tcacaggagc agccgaccgc ctcctcgcag ccgaccacct tcccgcagcc
    14881 gaccgcctcc tcgcagccga ctgcctccgc gccgcccccc gcctcgcagg agcagccggc
    14941 cgtctccccg cagccgatca cctcccgcgc ccctgggccg ctgccgccgt cgcctgatga
    15001 gctgatgtcg cggccgacgg cgggcgagag cagacccctt ccccaggcca tgccttccga
    15061 cggcctcgcc gcggccctgc accgagcctg cgcgctcgcc ttccccgacc cgcccgcccc
    15121 cgcgaacggg gcctccccgc acgctcccgc agccgcccgc tcatcggacc ggcccgcccc
    15181 gccacgtccg cccgtgcaag cgacccaccc ccttcccgcc ctccggcccg cgccccgcct
    15241 gacgggagcc gtcgcacgcc gcgcctcgcc catcgccggc taccgcccgg tccccctccc
    15301 ggcaggagcg ctcggggcgg tgctggcggc ggcctgcgcc ggctacccgt ccgacctgcc
    15361 cggcaccagc gcggggccgg ccgcgacggc cgtgtgcgtg ctgtccctgc gcgtggacgg
    15421 cctgccgcgc ggcgcctact ggtacgaccc ggccggccac acgctgcacg cgtcggccac
    15481 ctcgatcgac gccgtgacca ccggccccct gctgcccaac acccgggtgg cgctgcgcgg
    15541 ggccgccgcc gtgctgatcc ccgtggggga cccggtcgcc ggcgcgccca cgttcggcga
    15601 ccgctggtac cgcatgcagc agatggagac gggcctgatc acccaaaggg ccgcgctggc
    15661 cgccgccgcg ctgggcctgg ccgcccgcat ccactccgac ggcgcgaacg agaccaccga
    15721 cgacgtgctc ggcctcgccc gaacgccctt gaggagcctg tccttcctgg tgatgggcac
    15781 cccaccgacc ggcgggcccc tggtgacccg cccgatcccc gcccccgtcc acgaggaggt
    15841 gatggacgct ccgacgacac agcgtgaccc gttcgacggc ttcgtaccga aagaaaacac
    15901 agaaggagat gcacatgtcc gctgagaacc tgaagctcga cctgcgcggc ctggagatcg
    15961 actcgatcga cgtcgtgtcg gccgactcca tcgtggcgga gggccacggc accatcgaga
    16021 ccggcgcttc gtcctccccg ggctactgct cgtcgtacct gacggccatg agctgctggg
    16081 ctccggagct gtagagccgg cgtcggccct ccggtgagcc cgtcgcggcc accgggatga
    16141 cgagcagggt cgagggcgcc cgtgccgtgg gcgccctcgg cccctgacga acccttccga
    16201 ggagcgcgtt ccattgaccc aggtagcgca cgtcgtcccc gtcgcggggg acggtgaccc
    16261 tgtaaggctc gctgatcccg attatgcact gtcgcccgtc ctggccgttc gcgtcgcggg
    16321 gctgcccgtg gccgggctcg aacggatgcg gtgcacccgc acgtggcggc tcgtggacga
    16381 gctgacgaac gtcacgtccc ggctgcggcg ggagggcgcg gagctgtcgg atccgctgca
    16441 cgaggtgatc ggcggcgtgg cggccggacc gctgcgggcc gggctggtgg cgctgcggcg
    16501 cgcggtgttc gcggggcggc ggcccagcgg gcgggccgcg tccgccgagg tgctggccgc
    16561 cctgcccgcg gacctggccg ccaggatcgg cgcgtggacc accctgaggc ggcgcgccga
    16621 cgagctgcgc gcggcgctcc cggacgtact ggcggaggag acgcgcgaga agacggcggt
    16681 gctgcgcgcg gcggtgtccg acgccgggtt ccggcacggg ctcgcccagg gcagcgccgt
    16741 gctggccggc cgcctcgaag cctggctcgc cgggcccgcc gaccggccgc ccgaccgtca
    16801 ggagctgctg cggctggccc gctacctggc cagggccagc gtcaagacca gcccgtacgc
    16861 cacgttcacc ctcagcgggc tcggccggtg ggacacggac gggccggccg tgcgcacggg
    16921 cggcgagccg tcctggcagc tcatggccga gctcgaccgg gcggtcctgc gcccgctgtg
    16981 ggccgtgctg acccggcacc ggcgggtacg ggagcgggcc cggctccggg tcaacccgtc
    17041 cgccgccgac gacggcgacc gcatctggtt cctcagcccc gggcctggcg agcccctttc
    17101 ctcggttccc gctaccccgc aggtccggca ggccctccac tgggtacgcc ggcaccccga
    17161 cgccaccctc gccgccgccc ccggcatcga acccctggcc gaggcggggc tcctggaata
    17221 cgtgccgccg tacgacgagc aagggcccga tcccttgggg gagctggcgt cgtggctggc
    17281 ggccgacggc ccggccccgt acacgctggc cgtgacccgc gccgccgcag ccctgcacgc
    17341 ctcgaacggc gcggacgcgt ccgcagccct gcacgcctcg aacggcgcgg acgcgtccga
    17401 agccatgtgc ggcccggacg gggcgaacgc gcccgaaccc cagcccagcc cgaacggcgc
    17461 gaatgtgctc gaactcctgc agatggagcc tggcgacggc gggaagacga ccgaggcggc
    17521 gcccgacggc atggctgcgg cacctggcgg cattgccgcg gaaccctgcg ggatcgctgg
    17581 gacgtcgggc ggcgacccgg agaccgccga gatcgtccgg gcggcgctgc gggaggtgct
    17641 gccgcctggg ccgtccctgc ccgacaagaa cctgctctgg cacagcgccg tcatccccgg
    17701 cgtcgccgga cggctgaacg ccaccgcctg gcgcggcgtc tgcgacgacc tcgacgcgtt
    17761 gcgcgggctg ctcggcctgt tcgaccccga cctgcccgtc aagatcgccg ccgccgcgta
    17821 cttcctggac cggttcggcc ccaccagccg cctccacgcc atggccctgt accgcgacat
    17881 ccacagcggc acaccgggcg cgggcagcgc gctgctgcgc gccatgctgc gcgacccggt
    17941 cgcgggcacc cgcgcccttc cggacaccga cccgcccccc ggcctgagac gcctcaccga
    18001 gctgcggcgc ggcttctggg aacgcctcgg cgcaggcccc atcccgagcg acgtgagcac
    18061 gagcgacccg atgcccggca cagccagccg cgtggccgtg gtggatctca cggccgcccg
    18121 gctggccgac ctggcggagg gctggccgag cttcgtccgt ccgcccggct ccatctgctg
    18181 ctacgtccag gccgtgccgg accccagcgg cgtgcgcgcc gtcgtcaact ccgtctccgc
    18241 cgggtacggt cgcggcctgt cgcggctgca ccggctggtc acgctggccg gcggcgaggc
    18301 gccgcccgtc gcggacctgc gggcggcgca gggcgaggtc atggtggccg agtgccgggg
    18361 tctcgtcggc ggcgggctca acgtccggcc cgccacggcc gacgtcgccc tcgaccaccc
    18421 cttcaccgcc cccgactcgc acctcccacc ggtcaccccg gcggagctca ccgtcgccta
    18481 cgaccgggaa cacgaccgcc tgaccctgct cgaccgcgcg ggccgcccgg tacggcccgt
    18541 gcacctgggc atgaccgccc agtactggtt gccgccgtgg ctgcagttcc tggtgcgggt
    18601 gttcggggag ccgtccacgg cgatggtgcc cggctgggtg ttccgcaccc gcggcgagcc
    18661 gcccgccgag ggcgcggtgg agcgctggcc ccgcatggac atcggacggg tgacggtcgc
    18721 acgggcggcc tggcggctgc gggccggggc gttcccggtg ccggccaagg gggagagcga
    18781 ggccgcctac ctgccccggc tggccgaatg gctgtcccgg cacgggatgc cgcgccgctt
    18841 cttcgcccgg gtcgtggacc tgggacaggg cctgctggcg ggcctgctga gcaaggaccg
    18901 caagcccatg tacgtggacg tcaccgaccc cctgctgctg accggcttcg tacgcacgct
    18961 ccgcgacccg gccgccctgc tggtcctcga ggaggccctg cccgacccct cccaggcccc
    19021 cctgtacggc accgacgccc gcgtcaccga gtacgtcatc cagctctcca ccaggccgac
    19081 atcatgacgg cgacccccac gcacccgagc gacgccgagc accaccgccc cgacgcagcc
    19141 gccgccaagc ccgacgcccg gcctcgccgg ccggatgccg catctgacgg tgcccggccc
    19201 caccggccgg acggcgcgcc cggcgccgtc ccgcctctcc ggtcgggtgg cgctcctgac
    19261 gttgcccggc tggacgctga gaaccggtgg gtcagcgcgc acctgttcca cttcggcgac
    19321 ctcgacccgc tgatcaccgg cgtggtggac ccggtgacgc gggagctggt ggccgacggc
    19381 acgatccgcc gcgccttctt cctgcgctac tgggagggcg gccagcacgt acgcctgcgc
    19441 ctggaagtgc ccgaccccgc acggcagcag tgcgtccgcg acctggtacg cgagcgggcg
    19501 gcggcccact tcgccggcca cccgtccccg gaggtggacc cggcggccta ccgggccttc
    19561 gccgccgcca tggcccgggg cgagcgccgc gccgactacg acgagcggct gcacccgccc
    19621 ggcacggtgg cgttcatcgg ctaccggccc gagtacgagg cgtacggcga cgccgcctgc
    19681 gtggccgccg ccgaacgcca cttcgccgtg tcgagccgcc tcgccctcga cgtgctgggc
    19741 gccggcacgg acatgggccg ccgcacggcg atcgggctgg ccgcgctcac catggcgatc
    19801 gccgcctgcg agcccgacct cccctccgcc gcccaccgcc tcgccaccgc cacccgcgcc
    19861 ttcgaccccc ctcccaccac ccaccctccg gccacggatg ctcgtgcccc cgtcacaccg
    19921 ccgatcgggg cagtgccttt cgggaccccg gctgaggcgg cgcctcccgg gccgatgccc
    19981 ggcatccgtt cggaagtggt gtcttccggc accggccccc gcaccctggc tgaggcggcg
    20041 ttttccgggg tgaccgctgc catggaggag gactggcggc ggcgtgagaa ggcgttgctc
    20101 gcgcagacca gaaggctgtg ggacgcgccg gagtccgccg gcgggttgct ggccgcgtgg
    20161 gcgtcgtcgc tccgtgccct gcgcgacgac ctcgacgccc tgcacgccga gggccgctgt
    20221 gctcctcgcg actcgggctc gccgcacgcg ctgctcgcgc tggccgcgcc gcccgagcgg
    20281 cgcaccgtgt cgctgatcct gatgcggtgc gtccacctgt tccacaaccg gctggggctg
    20341 cgtgccggag ccgagcagca cacgacgttc ctggcgggcc gcgccgtcgc cggcctcgcc
    20401 gaccccagga ggtggtcccc ctgacccgct cgcccgcgtc cgaggccccg gcgtgctcgc
    20461 ccgcgcccga cacccctgcc tggcactgcg tgcacgtcta ctaccacgcg cccgacaagg
    20521 acgccctgct gctggacgcc gtgcggccgc tgctcgacgg tctgcggggc gaggtcgcgg
    20581 cggcgtacgt gctgcggcac tggaggcagg gcccgcacct gcggatcaac gtcaaggcgg
    20641 cgccggccgt gtgggagcgg gtggtgcgcc cgcgggtgga cgaggtcgtc ggcgggtacc
    20701 tgcgtgagca tccctcgagg gccgcgctcg acccggacga gagcctgccc cggcatcgcc
    20761 tgctcgccat gcgggagcag gagcgcgggc cgctcacgcc gtggccgccg gacaactcca
    20821 tccgcgacgc gccgtacgac tcccgccggc acgtcctcgg caccgacgag gaggcggacc
    20881 tgctggccgc gttctacgtg gacgccaatc cgctgctgtt cgacatgctg gagcacgtgc
    20941 gggcggggcg cgacggcaag accgggctgg cgctgagtct catgctgacc atcgcgcaca
    21001 cctcgcagcg catcgaccgc agctacctgt cgttccggat gcacgcggag gggtacctca
    21061 cgtgggcggc cgacccgggc gccgcccggg cgtccttcga gcgcacgttc cgcgagcggc
    21121 gcgcggcgct gacgcggcgg gtccgggacg tcgtcgcctg cctcgacgac gccggtgccc
    21181 cgcctgtgcc gttcgtacgg gagtgggcgg cgctgctgga gcggtaccgg ccggagatcg
    21241 cggcgatgat ggaggacggg cggctggtcc agccgacgat cgagccgggt gaggcgttcg
    21301 cggcccggcc cggggagccg cgcgcgccgc agcgtgagcc gagcgagttg caacgcctcg
    21361 tcttcgacaa ccccgcctac cacgaggcga tcttcagcag cccggccttc cggcggtacc
    21421 gggtgctgct caactacacg tatctgcatc tgacgcggct cgggctgacc ccgctcgacc
    21481 ggttcaggac gtgccacctg ctggcggacg cggtggagga ggtctacggc ctgtcggggc
    21541 tggactcgct gcgccgcttc gcctcggccg gggccggagc gacggccgat gggggcaccc
    21601 agcccgtgac gtgatccccg cgagggcatg agccgcgccg ccgggcgtct cagggcagac
    21661 ggtcatgccg acggcgggca gtgtcagggg cgggtcgtca ggggtgggtg gtcgggggtc
    21721 gggggtcggt ggtcaggggc aggcgatcag gccggcggcg gtgagggtca ggtgccgggc
    21781 caggacctcg gcggcggtgt cggcgtcgcg ggccagggcc acctcctcca ggcggcggtg
    21841 ctccgccagc ccgtcccgct ccggcgtgcg ctgggccgac cagcggcggg cgagctcgct
    21901 ggccgtccac aagcggtcga acgtgtccag caggacgggg ttgccgcatc cgtccagcag
    21961 ggtgcggtgg aagacgcggt gtgcctccga ccaggcgctg ctgtagtact cgccttcctc
    22021 cggcacgtac gcgggggtgc gggcgaggcg gtggtgggtg gcgcggacgc gggcctccca
    22081 gtcgaggtcg ccacgctcaa tggccaggcg cagcatggcg ggctcgatcg tgcggcgggc
    22141 ctcggcgatc tcctgccagc gccggtcgga gaagtggggg acggcgaagc cgcggttcgg
    22201 cagccggacc gcgatgccct cgccgaccag ccgcaccagg gcttcgcgta cgacggcgag
    22261 gctgacctgg tgctgctggg ccagctcctg gggcttgagc gcggcgccgg gggcgtactc
    22321 gcctctcatg atcgcctctt ggaggcgggc gtggacacgc tcggagagca tctgcgtcat
    22381 gccaccatca tagacgattt gccaaataat cgattatttg tgttatcgtc gatcgtgccg
    22441 cgatcgaggc ggcatcccca cttccgtaga ggaacgacac gatgagcttg aacaacccct
    22501 tcgcccgcct ccccgaggtg ccctccttca ccgtcaccag cgccacgctg gccgacggcg
    22561 agccctggcc cgccgcgcag ctgtccgccg ctctcccggg cggcggggac gtctccccgc
    22621 acctgtcctg gagcggcgcg cccgagggca cgaagagcta cgccgtgacg gtgtacgacc
    22681 cggacgcgcc gacgggctcc gggttctggc actgggccgt ggccgacatc ccggccggcg
    22741 tcaccgagct gcccgagggc gccggcgacg acacggggtc cggcctcccc gccggcgcct
    22801 accaactgcc gaacgacgcc cgcctgcccc gctacatcgg cgccgccccg ccggccgggc
    22861 acggcccgca ccgctacttc gtcgtggtgc acgccctcga cgtcgagcac atcggcgtcc
    22921 cggccgacgc cacccccgcc tatctcggct tcaccatctc cggccacgtc ctggcccgag
    22981 cggtcctgac ggccaccgcg gaaaccgccc ccgcggagac cgcccccgca gaagccgcga
    23041 ccgccaccgc tggagcctca tgacggtcac cccgatcgag ctgttcgacg ccggcatcca
    23101 cctgcgccaa ggcggccgca tccacgccgg caaggccccc atggatccgg gccgtgacgg
    23161 ctggcagctg acggcgttcc acgccaagac cggtgccgac gtgcacgccg accactggca
    23221 ggtgaacacc gaggccgagg aggtcgtctc ctgcatcatc ggcaagatcc gcctctacct
    23281 gtgccccgaa cgtccgggag gccaggagga ggagatcagg ctgacggccg gcaccgccgc
    23341 gatcgtcccg cgcggccggt ggcgccggat ccagctcgac atccccagca cgatcatgac
    23401 gatcaccctc acgggcggcg cacggctgga ggaacgcgcc ggccgctccg cgaaggatcg
    23461 gtgatactca catcgatacg accaggccgg tatcatcgcc ctcatggcca ggagaacgaa
    23521 ggcgggcacc cccgccccgg aggggcccgc cggcgggcgg gagctgaccc gtcagcgggt
    23581 gatcgaggcc gcggccgacc tcctggcgcg cgaggggcgc gaggcggtca ccacccgcgc
    23641 ggtcgcggcg gcggccgggg tgcagccccc cgcgatctac cgccacttcg acgacatgga
    23701 cgggctgctc gacgccgtgg ccgagcacgg ctacgccagg ttcctggagg ccaagcgcgc
    23761 cttccccacc cccgaagacc cggtggagga cctgcgggcg gggtgggacc tcgcggtcga
    23821 gttcgggctg gccaacccgg cgctctacgc gatgatgtac ggcgagcccc ggcgcggcac
    23881 gagctcggcc gcgttcagga ccggcatgga gatcctccac gggcggatcc gccgcctggc
    23941 cgccgccggc cggctgcgcg tggacgagca gctggccgcc gccctgatcc acgccacggc
    24001 ccgcggcgcg gtgctcactt ggctgtcgct gcccgcggac cgccgcgacc cggccctgct
    24061 gagcaccatg cgcgagtcca tggtcaccgc cgtcacgacc gaacgccccg ccgtccggga
    24121 gccgggcccg gcgggtgccg cccgggccct gcgggcggcg ctgccccagc agaccgtgct
    24181 cagcgaggcc gagcagcggc tcctcggcga atggctcgac cgcctggccg ccggctgacg
    24241 gccgggcccg ccgccccctg aggccggatg ctcgcgcagg ccgctgccgc cgggccggcg
    24301 gtctcgcgca cgtccgcata agcccccgca aagcacccgt cgtcacgtca ggtgcttgcg
    24361 cagggcgctc tccagggaga tgggctcgcg gccgagcaac gtgcccagcg ccggatcgac
    24421 ggcggcgaac tccccggcgc gtgcggccag gaagatgtcg atcaggtgcc gcgcgtactc
    24481 ggcgggcacc ccgtgctccg tcagctgctc ctggaaccgg tcgtcgggta cggcgacccg
    24541 ggtgacggcc cgcccggtca cctcgccggc gacccgggcg aggtcgtcga aggtgaacgc
    24601 ccgccccgcc gtgagcgggg gagtgggccc gtcgaagcgc ccctcgtcgg ccaggacggc
    24661 ggcggccgcc tcggcgaggt cctcgtggaa ggtccagctc accggcccgt cggcgggcag
    24721 cgcgagctgg tcgccgtgcc tgccctggtc gaagaaccgc agcgcgctgg ccgcgtagaa
    24781 cccgttgcgc agcgcggtgt acggcacgcc gcacccgcgc agcgcctcct cggtggcggc
    24841 gtggtcccgg cacgcctgga agtgcgagga ggcgctcgcg cccatgtggc tggtgtagag
    24901 gacgcggcgg gcgcccgccg ccacggccgc gtcgatcgcg gcgcggtgct gccccacggc
    24961 gtcggcgccg aaccggtcga tcgagacgac cagcacctgg gtggcgccct cgaaggcgtg
    25021 ggcgagcgtg gcggggtcgg cgaagtcgcc gcgccgcacg cgcacgccct ggtcggcgaa
    25081 cgcccgcgcc ttgccggggt cgcgcacgct gacgccgatc cggtcagcgg gaacgcgggt
    25141 gagcagccgc tcgacgatct ggcgcccgag ctgtccggtg gcgccggtca cgatgatcat
    25201 gtacgtactc ccatgcgttg gaaacgcacc aagagtatca ctggaaatat caatggaaac
    25261 agcaagagag ttacattgat atcgccctgc cgtgccgcca gtagccgaag aacgcgacgt
    25321 cccccttggc cgcgccccgc tcggtcacca gatgccggcg cagcccggtc gccaggcggg
    25381 actcaccggc gacccacgtg tagaaccgcc cctcgggcag agaggcccgc ttgacggtct
    25441 ccagggccag cgcgcccggg gtggcgccgg agccgtcccg ggccaaccag tggatccgca
    25501 ccccctccgg cgcggtcacg tccgtgcgga tgtccgcgct cgacggcacc tccaggaaga
    25561 cctcggcgac gagcgaggcc ggcgcgctgt cgaggatcgc caggatggcg ggcagcgcgc
    25621 tctcgtcccc ggcgagcagg tgccaggcgg cgccggccgg cggcaggtag gagatgccca
    25681 tgtcgaagat gcccgccggg tcgccgggac gggcccgctg cgcccacgcc gaggccgggc
    25741 tctcgtcgcc gtgcagggcg aactcgatgt ccacctcgtt cgcctccggc cgggcccgcc
    25801 ggatcgtgta gttgcgcacc cacgggcggc gcgacttcgg ctgcaggagc acctgcgcca
    25861 tccacgcctc gttcgacagg gtcggcatcg tgagccccgg ttgcccgtcg cgggggaaga
    25921 acagccgtac ggtctggtcg aagcccgtcg ggcgcagccg ctccagctgg gggccgccga
    25981 gggtgacggt ggtgaagtgg gggctcagtc gggtgttcct gacgacctcc aaagtgatca
    26041 tgtgccggga ttcgggcatg cgtaccttcg gcagcaccgg aaaacgctcc ttagaggtcg
    26101 aggacgaggc gggccgagcg cgagcgggac acgcacgcgt acatgcggcc cggcgcggcg
    26161 cccacgtcgt cgcggtgctc gggttcgccc tccaggacgg tcacctcgca actgccgcag
    26221 accccctccc ggcacccggc gggcacgggc aggccggcgt gggtcagggc gttcagcagc
    26281 gactcgccgg cgggcaccgg cacggtccgt cccgaccggg cgcacacgac gtcgaacgcg
    26341 gtgtccgggg cgaacgtcct gggccgcggg cggaaccgct cgacgtgcag ccgttcggcg
    26401 gggaagaccg cctcgcaggc gtccagcagg gaagtggggc cgcagcagta cacgacggtc
    26461 tccggcgcca gcccggcggc gagcgcggcg aggtcggggc ggccgtcgtg cccggtggcc
    26521 acgaccgtca cccggtcgcc gtaggcggcg cgcagctcgc cggcgaacgg catggacgcg
    26581 tacgtgtgcc ccgcgtacac cagcgagcag gacgcgcccg cgtcggcggc ggcccgcagc
    26641 atcggcagga tggcggtgat gccgatcccg cccgcgagga agaggtagga gggggcgggg
    26701 acgagcggga aggtgttgcg cggcagcgac acctccagcg tgcggcccgg ccgcaggtag
    26761 cggtggatgt agtcggagcc gccccggctg agccgttcgt ggcgcaccgc gatccggtag
    26821 cgctcgcggt cgcgcggatc gccgcacagg gagtactgcc tggtcagcca gttgggcagg
    26881 gcgaggtcga cgtgcgcgcc cggctcccag ggggccagcg ggccgtgcgc gccgcgcagg
    26941 gtgagggcga cgacgtcctc ggcgggacgg tcgatgcggt cgaggatggt gagctgcatg
    27001 gtcgtccgtc cctgtcagta cagctgccgg tagccctctt cgaggcgtgc ctcgaggagc
    27061 cgcggatcga tgtccatccc gaactgcgcg gccgccacct cgccgagcga cggcagctcg
    27121 tcggcgagcg cctggctggc cgggtcccac aggcgggagc ggatgagcgc ccggccgcag
    27181 tggaagtaga cctcctcgac ctccacggcg atggccagct ccggctcccg cgcctcggtc
    27241 tgcatgcgaa cgagcacgtc gggctcgtcg gtggcgtacg cgcggccgtt gacgcgcagg
    27301 gtctcccgcg agccggggac gaagaacagc agcccgatcc cgtcgttctc ggcgaggttg
    27361 cggaaggagt cggcgatccg gttgccgggc cggtcgggga tggcgagcag gtgctctccg
    27421 agaaccttca cgaagccggg gtagtcgccg cggggcgagc agtcggcccg gccggacgcg
    27481 tcggcggtcg ccatcgtcag gaagggtgag tgggcgatga agcggcggga gtgctcgtcg
    27541 atgtggtcct ggatcttgct cttgatcatc gcgtcgggct cgccgagccg gtcgcggacc
    27601 tgttcgatgg acacccggcg cggccgccgc tcgatgagtg gcgcattttg cctggtcatg
    27661 gcaccattat gagcaatcat tcagttcttg cgctactcgc tttcggcgct cttccgcagg
    27721 aggtcagcgg tgtcgaggga cccacggctt cacccgcgca aacagccgcg ccaggtccgc
    27781 gccgagctca cgcgccggcg catcctggag gcggctgctc aggttttcac cgagtacggc
    27841 tacgccgccg gcaccaccaa ccgcatcgcc gagtacgcgg gcgtgtcgat cggatcgctg
    27901 taccagtact acccgaacaa ggacgcgatc ctgctggagc tgatgctcgc ccacctcgac
    27961 agcggcgagg aagaggccac ccgccgccag acgggggagc tgccgggcac ggccgagggc
    28021 ctcatgcgcc tgttcgtgca ggccgccatc gccaaccacc tggaggaccc gcggctgctg
    28081 cgcgtcatgg tcgagcaggc gccgcgctcc ccggagctgc tgcagcgcgt ctaccagttc
    28141 aagaacgagc gcaacgccca cacccgcgac ctgctgcgcc gctaccggga ggtgcgggtg
    28201 tcggacctcg agacggccgc ccggatcatc aacgccacga tcgagctggt cgtccaccag
    28261 gtcgtggccg agcacgagcc catcgacctg caacgcctgg aggacgagct cgtcgcgatg
    28321 ttcacccgct acctgacggc ctgaacggcg gggctcacgc ccaggtgacc ggcagcgagt
    28381 gcaccccgaa gatcagcatc tcgtcgcgca ccggcacctg cgcggccggc accgccaggc
    28441 gcaggcccgg caggcgggtg atcagctcgc ccagcccgat gcgcagctcg atccgggcga
    28501 gctgctgccc gaggcactgg tgcacgccgt gcccgaaggc caggtgcggc gtgcgcgggc
    28561 ggcgcaggtc gagcatgtcg gggtcgggcc agtggcgcgg gtccctgttg acctcgggcg
    28621 tggcgatcac cacggtcgcg ccggccggca ggtccacgcc gcccagcgtc accggctcct
    28681 tggcgacccg gctgaccccg agctggatga tcgacaggaa ccgcagcagc tcttccaccg
    28741 cgtcgccgat cagctccggc tccgcgcgca gggccgcgag ctggtcgggg tgctccagca
    28801 gcgcgaacgt cccgaggccc agcatgttcg ccgtggtctc gtggccggcg gtgagcagga
    28861 gcagggcgac gtccacgagc tgcgcgtccg tcagcggcgg gtcggcgtcg tggacgagcc
    28921 cggacaacag gtcgccggcc gggttcgcgc gcttggccgc cacgagccgc gccatgaacg
    28981 cgtgcagccc ggcgcgggcc gccgcctgct cccgcatggt cgcgctcgcg ctcagcccga
    29041 ccgccgtccg ctcctggaac tccgcgcggt cggcgtaggg gacgcccagc agctcgcaga
    29101 tgaccagcga cggcagcggc agcgcgaacg ccggcaccag gtcggccgtc cgggtgccgg
    29161 ccgcctgcat cgcctcgacg tgctcgaccg cgatctgcct gacccgcgtc tccagctccc
    29221 gcatccgccg caccgtgaac tgccccgtca gcacccgccg cagccgggtg tgctcgggcg
    29281 ggtccatgaa gacgaaggcc ccgtcggtgc gctccccctc gggcggggcc tgcggcggcc
    29341 ggagcgaggt ggcgtcccgg tgccgcagct tgtcggcgct gaaccgggga tcggccagca
    29401 ccgtacgggc ctcatcgaac cccgtcacca gccaggcccg cgcgccgttc agcagctcca
    29461 cctcccggac cgggccgtgc ccccgcaggc cgggcggcgg ggagaacggg tcgcgcccgc
    29521 gctccaccag gtccgccggc aggatccgcc gcatcgtggc ggtgctcacg cccgcgggct
    29581 gctcggtcag gctgtcgtcg gtcatcggcg tcccgttctc aatagggtac gttcgcgtat
    29641 ctaacggagg acaccgtaga tcaccgaaat aagatacgca agcggatcta aacggcgcgg
    29701 cggtgatcag tggggcggac gccgcgcagc cgcttgaacg ccacgctcag cgcgaacgcg
    29761 ttcgcgtacc cgaccctgcg cgcgatcgcg gccaccgtga ggtcggtctc ccgcagcagg
    29821 tccgcggcca gggcgacgcg ccagcccgcc aggtacgcca tgggcggctc gccgacgagc
    29881 gcggtgaacc gccgggccag cgccgcccgc gacaccccgg ccttggccgc cagctccgcc
    29941 accgtccacg gatgggcggg cgcgtcgtgc agcagccgca gcgcggcgcc cgcgaccggg
    30001 tcgtccagcg cccggcacca gccggggacg ctcgcgtccc ggctggcgaa ccaggcacgc
    30061 agcgcggaga ccagcatcag gtccagcagg cggtccagca cgagctgctg ccccggccgg
    30121 tcgcgggcga tctcctccgc gacgaccccc gccgagggga acgggcccgc ctcggccggc
    30181 accaccagca ccggcggaag ggcgcgcagc agccgctcgc tgagctcgcc ccggcgctcg
    30241 aacgtcccgc tgaccagcac ggcaccctcg tcgcccgggg cgtcgcaggt gagggtggcg
    30301 gcgcgctcga cgcctcccgc gcccgggcag tagtcggcgg cggtcacctc cagggcgggc
    30361 gcggtcgccg ggtcgtcggc caccgtgtag ggcgcgtcgc cccggacgac cgcgatgtca
    30421 ccggccgcga ggcgtaccgg ctcgtggccg tcggcgacca cccacgcgtg gccgcgcagc
    30481 atcgtggcca gcgtcagcgg ggcgccgctc gccatccgca gcgcccacgg cgggcggatg
    30541 accgcccgcc ggaagacggc gccgcgcgcc cgcacctccg ccagcagctc cgacacggca
    30601 tccacgaccg ccagcctaga cgctgagaca tcgacatgag gcttccagcc atggaacgtc
    30661 tcagccccgg ccggttgact gggcgccatg tctgagcaac cgattctcgt caccggagcg
    30721 accggcaaga ccggccgccg cgtcgtacgc cgcctgcgcg cccaaggact gccggtccgg
    30781 gcggccgccc gcggcggcga gcacgccttc gactgggccg accccggcac ctgggacgcc
    30841 gccctgcgcg gcgtgcgggc cgcctacatc gtgcaggtgg acggcacgaa gctggtgcgc
    30901 ccgttcgtcg agcgggccgc ccggcacggg gtgcggcgcg tcgtcctggc ctcgggacgc
    30961 ggcatcgacc tgcccggcta cgccaacgac cgcgacggcg tcctggaggg cctgctcgac
    31021 agcgaggccg ccgtgcggga gagcggcctg gagtggacga tcaccaggcc gggctggttc
    31081 gcgcagaact tcagcgaggg cttcttcgcc gacgccgtcc gcgccggcga gctgcggctc
    31141 ccggccggcg acggggccgc cagcttcgtc gacgccgagg acatcgccgc cgtcgtcgcc
    31201 gccgcgctga ccggggacgg gcacgcgggc caggtctacg agctgtccgg ccccgaggcg
    31261 gtgaccctga ccgaggcggc cgccaccatc tccgaggcca ccggccgaaa gctccggtac
    31321 gtgccgatct ccccccggga gtacgtcgcg gagctcgtcc agcagggctg gccggccgcg
    31381 gacgcggcgg cgttcgcgga cgtcatcgag ccgctcagga acggcacgga cgcctacgtc
    31441 tccgacgggg tgccgcgcgc gctcggccgc cccgcgagga cgttcgccgc gttcgccaag
    31501 gccaccgcgg ccgagggcgg ctggcccgcc taggccgccg gggcaggccg gaacgcatgg
    31561 aacgggatgg aacgcccctt ggtccgaggc gccgtcgtcc gaggacggcg ctcg
//
