LOCUS       NZ_CP017717            22436 bp    DNA     circular CON 03-MAR-2024
DEFINITION  [Actinomadura] parvosata subsp. kistnae strain ATCC 55076
            chromosome, complete genome.
ACCESSION   NZ_CP017717
VERSION     NZ_CP017717.1
KEYWORDS    RefSeq.
SOURCE      [Actinomadura] parvosata subsp. kistnae
  ORGANISM  [Actinomadura] parvosata subsp. kistnae
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Streptosporangiaceae; Nonomuraea.
REFERENCE   1  (bases 1 to 13047416)
  AUTHORS   Nazari,B., Forneris,C.C., Gibson,M.I., Moon,K., Schramma,K.R. and
            Setedsayamdost,M.R.
  TITLE     Nonomuraea sp. ATCC 55076 harbors the largest actinomycete
            chromosome to date and the kistamicin biosynthetic gene cluster
  JOURNAL   Medchemcomm (2017) In press
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 13047416)
  AUTHORS   Nazari,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2016) Chemistry, Princeton University, 20
            Washington Road, Princeton, NJ 08544, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 18-JUN-2015
            Assembly Method                   :: Celera Assembler v. Jun 2015
            Assembly Name                     :: SmrtPipe 1.87.139483
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 110.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/03/2024 13:15:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 12,000
            CDSs (total)                      :: 11,919
            Genes (coding)                    :: 11,783
            CDSs (with protein)               :: 11,783
            Genes (RNA)                       :: 81
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 136
            CDSs (without protein)            :: 136
            Pseudo Genes (ambiguous residues) :: 0 of 136
            Pseudo Genes (frameshifted)       :: 36 of 136
            Pseudo Genes (incomplete)         :: 98 of 136
            Pseudo Genes (internal stop)      :: 10 of 136
            Pseudo Genes (multiple problems)  :: 6 of 136
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:57:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1331415
            Orig. end                         :: 1353851
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP017717.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22436
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="6"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22436
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22436
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12436](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12436
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    complement(467..482)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 22.3"
                     /tool="antismash"
     misc_feature    1141..1156
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.92"
                     /tool="antismash"
     gene            complement(1282..3561)
                     /gene="yicI"
                     /locus_tag="BKM31_RS05995"
                     /old_locus_tag="BKM31_05975"
     CDS             complement(1282..3561)
                     /EC_number="3.2.1.177"
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="yicI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020547513.1"
                     /locus_tag="BKM31_RS05995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_05975"
                     /product="alpha-xylosidase"
                     /protein_id="WP_080037169.1"
                     /transl_table=11
                     /translation="MKFKDGYWRLRPGVRAGYATAAFDVTVRDGTLRVLAPTREIARRG
                     DTIDGPVLRVDLSSPMPDVIRVRTVHFAGSVPASPAFGVRDDRPDVKIAVDGEEAALTS
                     GDLTVRVRRDAPWEMTFSAGGRELTRSAGKSLGLMRDPDERHFMVEQLRLSAGELVYGL
                     GERFGPLVRNGQSVDIWNEDGGTSSEIAYKNVPFYLTNRGYGVFVNHPGRVSFEVGSET
                     VSRVQFSAEGHDLEYLIIHGPTPADILRRYTALTGRPALPPAWSFGLWLSTSFTTDYDE
                     ATVTSFVDGMAERDLPLSVFHFDCFWMRRFRWCDFVWDPEVFPDPEGMLRRLKERGLRV
                     CLWINPYIGQASELFEEGAAAGHLLRRPDGTVWQDDHWQAGRALVDFTSPAAREWYAGK
                     LRGLLDMGVDAFKTDFGERIPTDVVYADGSDPERMHNYYSLLYNQTVHDVLAQRRGPGE
                     AVLFARSATVGGQRLPVHWGGDCESTFEAMAESLRGGLSLGLGGFGFWSHDIGGFEGRP
                     DPAVFKRWVAFGLLSSHSRLHGSGSYRVPWLFDEESVDVLRAFTRLKARLMPYLYGAAV
                     QAAAEGLPMMRAMHLEFPHDRGCDHLDAQYLLGPDLLVAPVLSADGEVSYYVPEGVWTR
                     LLDGTTVSGPGWRRERHGFDSLPLLVRPGAVIATGARDDRPDYDYADGVTLDAYRFADG
                     DSRTVTVPALDGTPAAVFEVSRHGDRLRARRLSGAPAPWNLRHAAAHAAAAPEIDHIEI
                     TLSAKE"
     gene            complement(3558..5549)
                     /locus_tag="BKM31_RS06000"
                     /old_locus_tag="BKM31_05980"
     CDS             complement(3558..5549)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020547514.1"
                     /locus_tag="BKM31_RS06000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_05980"
                     /product="beta-galactosidase"
                     /protein_id="WP_230466018.1"
                     /transl_table=11
                     /translation="MRALTERRGLLFGGDYNPEQWPEQVWREDAELMRAAGVNLVTVGV
                     FSWARLEPEPGKHDFGWLDRVLDLMAGHDIAVDLAVPTASPPPWLGHRWPETLPVDEGG
                     HRLWYGSRNQFCPSSGPYRERSQSITTALAERYADHPALAMWHVGNEYGEVCHCDVSAE
                     AFRGWLRARYGDLATLNEAWGTTFWSQGYGDWAEVVPPRRAPYIINPTQRLDWWRFCSD
                     ELRAHFREQRDILRAHTPDIPVTTNFMGFFKRVDYWSWAADQDVISNDCYPEPGNPLTP
                     ARTALTHDLMRGLAGGRPWLLMEQATSAVNWRAHNLPKPPGQLRLESLQAVARGADGLC
                     YFQWRASRFGAERFHAAMVPHAGPDTRLHAEVRAHGQELRGLAEVAGEPVPARVAMVFG
                     WESWWALEDRGRPSDRLNAVDQLLDYYVPFFERGVSVDVVPPGADLSAYALVVVPNLFL
                     LGDRDAAALTAYVQGGGVLVVGPFSGVVDENSHVRTGRFPVPLREVLGASGEEWLPAGQ
                     PVRCRWSGGLDFEAHTWTELLRADGAEVVAEFAEGDLAGRPAILRHRSGAGVAWYVGTM
                     PEPAALASLAGRALADAGVRGPLPDLPAGVEAVRRGTVLFLLNHGATTVRVPIPKPGVD
                     LLTGARAEGHVTLTPRAVAALRQEVPAA"
     gene            complement(5558..6625)
                     /locus_tag="BKM31_RS06005"
                     /old_locus_tag="BKM31_05985"
     CDS             complement(5558..6625)
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012742.4"
                     /locus_tag="BKM31_RS06005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_05985"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_080037171.1"
                     /transl_table=11
                     /translation="MTSLRDVAERAQVAVSTASAALNGTRPVAAATRRRVERAAAELGY
                     RPNLLARGLQSKRTRILALLFPAPRSGFGLTEMQFATGAAEAAKERGYHLLLSPESADP
                     IEELRHITGLGLVDGVLLMEVGLDDERPAVLAEAGVPFAMIGRTREPGGIDHVDIDFAA
                     TAEAAVAHVAGLGHRKLAFFNRAVDAHAAGYGPAVRAGREFERAAREAGLQYVGGYRPG
                     SAEEGGKAFEELLGAHPDVTALAVMDDHAAAGVIAAVARLGRRIPEDLTLLLVLSSARV
                     AGMFHPRLTTLEPPSAELGRIGARMLIDKLQGETQSRTQGEAKGETQGGPQRRLLPCRL
                     VVGDSSAPPREGGRW"
     misc_feature    6913..6928
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.24"
                     /tool="antismash"
     misc_feature    6913..6929
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.14"
                     /tool="antismash"
     misc_feature    complement(7018..7036)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.37"
                     /tool="antismash"
     gene            7084..8121
                     /locus_tag="BKM31_RS06010"
                     /old_locus_tag="BKM31_05990"
     CDS             7084..8121
                     /GO_function="GO:0004340 - glucokinase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0005536 - glucose binding [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /GO_process="GO:0051156 - glucose 6-phosphate metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014715.4"
                     /locus_tag="BKM31_RS06010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_05990"
                     /product="glucokinase"
                     /protein_id="WP_186403512.1"
                     /transl_table=11
                     /translation="MPGDQASYRPARLGFVGIDAGGTKVHVRYQLTPAHAAETFKIRSA
                     DYDSLDDLIEDCLKKIGYLPRALVAGVAGRPRPNGDVRVTNQPGWPVFQRDRFAAVRGV
                     RLEIVNDMIATVAGVRELTVAECRSLTPGIALSAPSRLVVAVGTGVGVGYADGEGRPHG
                     TEAGHIPWQPVGAREGDYLCWLQGRHPGVPISVEQSVAGLHGIEHLYDYLSTVRPPARR
                     LSERVGRARVEGQGIGALVMPEAVAGDPFCTELVRLLGVILGQFLRSMALVTLSQGGSI
                     WLAGSVLQSPGLAELLVADGCLLEAFRGGGAQHADLMEQIPMFLILDHEIAVKGALALS
                     KALAA"
     misc_feature    7120..7122
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(8129..8138)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.55"
                     /tool="antismash"
     misc_feature    complement(8196..8209)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.26"
                     /tool="antismash"
     gene            8305..9492
                     /locus_tag="BKM31_RS06015"
                     /old_locus_tag="BKM31_05995"
     CDS             8305..9492
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF012692.4"
                     /locus_tag="BKM31_RS06015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_05995"
                     /product="ROK family transcriptional regulator"
                     /protein_id="WP_186403511.1"
                     /transl_table=11
                     /translation="MLDLLSPPPAARDRTRLEIIKAIMAKPDTQQQLRRRTGYSAATIS
                     GVVRKLHEDGLVELVGASELNKEVRLLPLDGVAVGVEVGFSNIAVVARRAHQSHSDARW
                     GSSQVSAAPGEAAWLDSAVALIREVVEEVGQGPEDIGTVGMGIPRMIDPKTQRFAPPVL
                     APWQDGEDPAATLAGRLTRRAGKERAGMWKVRLDNDANLGAYAASVYQYPLKETLIYIK
                     ASTGIGAGIVIGGNVFRGARGCAGEIGHTPVQQNGRYCLCGGRGCLETVIGADAMLQNV
                     KTHLGGRPFEAPRSIRELIRSAKDGNPICSRVLREAAEQLGHSLGGLCNLLNPEVIVLG
                     GAFGRAGAIAREACESGIRRTAMAAVVDGLTVASSEMEHSSAHGALLMGIDGEGL"
     misc_feature    complement(9557..9572)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.38"
                     /tool="antismash"
     misc_feature    complement(9634..9647)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.19"
                     /tool="antismash"
     gene            10001..11722
                     /locus_tag="BKM31_RS06020"
                     /old_locus_tag="BKM31_06000"
     CDS             10001..11722
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="BKM31_RS06020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_06000"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_080037174.1"
                     /sec_met_domain="Asn_synthase (E-value: 3.3e-27, bitscore:
                     95.5, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRFYGTWPDGERVWAEHPEASLLLVGHCLARPADLRDGLAAALER
                     DEPRLLMDWPGAYAGLLLRHRGEVIAFTDLAGQFPLYYTSAPDELAIAAHPEVLTGPRQ
                     RALDRVMVAARIACPAVLPLWENRSPFETVARMPGGAVLRGRPGEVRLSPPLLRAADLD
                     EVDALRVALTEAVALRCADGPVSADFSGGLDSTSLAFLAARHTSVEAVVYHHPQVPAAD
                     LAEAVSFSHHDERIHLSTVQGSQDTLPYAALPQQAGRTSPGQRGAEPTRGSLAVRRAML
                     RLRHAKTAETRLHITGEGGDAIFGAAPSYLGELARHGHLRRLARHCAGQAALRHTSTLA
                     LAMRAGRLALTSPVAALARLSRRLLRPDQSELTWPDAIAWWPVDGAVLTWLTPLMRAEL
                     AEAVRDPGLAECLAPDGGPAQMAMRTELRLSAESQRHLRDLGALDGIRVHAPFLDNAVV
                     AAGLAVPSGRRGDPFTSKPLLAAALRGLVPQAVFRRRTKGDYSAEEYHGARVAARHLYA
                     LLDDSRLVAMGIIAAEPVRACLGRLLAGAPVPLGAMSQLFATENWLRCLENPFDWS"
     gene            11726..12436
                     /locus_tag="BKM31_RS06025"
                     /old_locus_tag="BKM31_06005"
     CDS             11726..12436
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033537.1"
                     /locus_tag="BKM31_RS06025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_06005"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_080037175.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.6e-08,
                     bitscore: 33.9, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.4e-07, bitscore: 29.9,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PF13471 (E-value: 4.3e-16, bitscore: 58.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLQLRIPDHVHHQTYGHGGVVLLNVSTGQWHALNDTAAHLWIGWA
                     GGAGFEESIAQVAGRYPATAPDIIRRDANLLLRDLVNRGLIETDLSDLRMAATMAGPEP
                     GCAARVPWRERLFALGSLLLAVVLLKLPFRATAGLLTRMRGRWCRSELPADRAETAAAA
                     VRHVADWYPGRTACLEISLATVLSAALRRRRLDWCLGAITDPYRFHAWVEIDSRPVAAV
                     HEPADPGYLRVLTL"
     aSDomain        11774..11989
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BKM31_RS06025_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="3.70E-11"
                     /identifier="RREFam002.1"
                     /label="BKM31_RS06025"
                     /locus_tag="BKM31_RS06025"
                     /protein_end="88"
                     /protein_start="16"
                     /score="33.9"
                     /tool="antismash"
                     /translation="HGGVVLLNVSTGQWHALNDTAAHLWIGWAGGAGFEESIAQVAGRY
                     PATAPDIIRRDANLLLRDLVNRGLIET"
     misc_feature    complement(12570..12585)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.02"
                     /tool="antismash"
     gene            12699..12848
                     /locus_tag="BKM31_RS59375"
     CDS             12699..12848
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BKM31_RS59375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_155126597.1"
                     /transl_table=11
                     /translation="MRRSDSRVEFEIKGRLRAPDWRWLLLLLLAVLIVVLRTDGDGVVI
                     QLLP"
     gene            complement(13100..14059)
                     /locus_tag="BKM31_RS06030"
                     /old_locus_tag="BKM31_06010"
     CDS             complement(13100..14059)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853142.1"
                     /locus_tag="BKM31_RS06030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_06010"
                     /product="arabinan endo-1,5-alpha-L-arabinosidase"
                     /protein_id="WP_080037176.1"
                     /transl_table=11
                     /translation="MRRLPRIVAAAASVLALTAAALAYPNPGRVTGDVVVHDPTMIRTS
                     SNYVLYSTHGYLEARTSTDRITFTRAGSAFRTPPSWWRTYSSANDPWAPDISQQGGRYL
                     MYYAVSSFGSNNSAIGLATSSTGQPGTWSDQGVVYATTTSNDHNAIDPNLLVDASGRWW
                     LSFGSYWTGIRMIRLDPATGKRHSSDRTLYHLATRPDAPYAVEAPDIIRHGTYYYLFAS
                     YDRCCAGTSSTYKIKVGRSTSPTGPYTDRAGTPMLNGGGTTVLETHGAIIGPGGQSVMS
                     DVDGDLLVYHYYDGNAGGTPKLGVNLIGWDSAGWPYVY"
     gene            complement(14344..14883)
                     /locus_tag="BKM31_RS06035"
                     /old_locus_tag="BKM31_06015"
     CDS             complement(14344..14883)
                     /GO_function="GO:0008703 -
                     5-amino-6-(5-phosphoribosylamino)uracil reductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013989.4"
                     /locus_tag="BKM31_RS06035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_06015"
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_080037177.1"
                     /transl_table=11
                     /translation="MSKLLYSVTMSADGFIARPGGDMSWLTPHLGPNPLVDDLVGEIGA
                     LLVGRRTYAGDDPNKGTDKEGAFEGAWQGPQVVLTHHVPGDPVPGVTFAGDLPSAVAAA
                     KRAAGGKYVNVLGADVARQCLEAGVLDEVLTIVAPVLLGDGVRLFEHPGGTNVRLERLR
                     AGHVPHAVNIWYRVVS"
     gene            complement(15016..16920)
                     /locus_tag="BKM31_RS06040"
                     /old_locus_tag="BKM31_06020"
     CDS             complement(15016..16920)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016625 - oxidoreductase activity, acting
                     on the aldehyde or oxo group of donors, iron-sulfur protein
                     as acceptor [Evidence IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013481.4"
                     /locus_tag="BKM31_RS06040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_06020"
                     /product="aldehyde ferredoxin oxidoreductase C-terminal
                     domain-containing protein"
                     /protein_id="WP_186403510.1"
                     /transl_table=11
                     /translation="MPFIVDLTSGNVTKEDRSAEKGHYGGSILGLRLMAERTAAGLDPY
                     DPETLLYVAAGMLGGTAAPGLAKAVFLAKSPLTGVAGEAHALGPFAAGMRGAGAEALAV
                     VGRAERLSYLLVAGGEVSVHGAEDLRGLGTAATTDALRARHGAGAHVAAIGPAGEHLVR
                     YASVVTDHAFAAGRYGLGAVFGAKNLKAIVCAGPAPAGVALAERADPVAVADLAALGEP
                     AGQTAAARAGLGDPAPVADPEAIAALTAYYREAMVTNKLAAWQAGLPGFAAWAGDPIDP
                     GYASVRNFSVTGAPGLRAPSAGDYDGRAVATTGSCPGCPNDCLKVYAPPGVERRTGGLG
                     QEAFVSLGWNLGIDDLDTILAANARCNDLGLDVVSLGGTLAFAMECAERGLLPGGPAFG
                     DAAALPGLIEDVAARSDALGDLLAEGSARAARRIGRGAAAYAMTVKDAEVPCIDPRPQP
                     GIGLGYALAPGGPRYDALEHDLDFDPVVGLAYCFPEAARVGALPAPAGELDEERGRRTA
                     RLLRLWSGLDALNVCLFASSPTRPLTIDHLTALVRAVLGVEFTLEDLLAVGQERLDAMR
                     AYALRESGGHLDETLPARLHEEAITEGPHRGAVLERAAFERARAAFYDELGWDPRVTA"
     gene            17073..18701
                     /locus_tag="BKM31_RS06045"
                     /old_locus_tag="BKM31_06025"
     CDS             17073..18701
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066: alpha/beta hydrolase domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012363.4"
                     /locus_tag="BKM31_RS06045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_06025"
                     /product="carboxylesterase family protein"
                     /protein_id="WP_080037179.1"
                     /transl_table=11
                     /translation="MATVIALATAALLLTTTPAIPPATSASGERPAASASGARPAASTT
                     GDRLVARTESGLVRGARADGVERFLALPYAAPPVGDLRWRAPQPPPSWKGVRAADAWGN
                     RCPAAASSNGPRSETEDCLYLNVFRPEGTRAGQRLPVLFWIHGGGLVNGSANQHDGTLI
                     AQLENVVVVSVNYRLGVLGYLVHPALAAESGQAGNYGLLDQQAALRWVRRNIAAFGGDP
                     RRVTIDGESAGGFSVCAHLTAPGSAGLFARGIMQSGSCVSRPLEDGERTGTQIATTLGC
                     PDPATAAACLRALPPGRLIDGPQYTSFTHGTPALPESPDTAVRAGRFQRVPLMIGYNRD
                     EGRTFLQGNRGWTRERYEEWVRTVFGDRAAAVLERYPWPARSDTFTSAYLTGAIATDAG
                     LLAGIGGCPALRLARDLSAYTTVYGYRFDHRTGPGLTPEPAGYVWGAGHAAELAYLWPS
                     FDNGTPIAPTFDAGERRLARDMVHYWGGFTRTGQPYAKGSARWPRLGDAVMSLRAAGRS
                     TPVPEATMAAEHQCDLWQPGSAGSS"
     misc_feature    17109..17111
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    18767..18780
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.27"
                     /tool="antismash"
     misc_feature    complement(18767..18784)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.08"
                     /tool="antismash"
     gene            18817..20073
                     /locus_tag="BKM31_RS06050"
                     /old_locus_tag="BKM31_06030"
     CDS             18817..20073
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889189.1"
                     /locus_tag="BKM31_RS06050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_06030"
                     /product="ROK family transcriptional regulator"
                     /protein_id="WP_080037180.1"
                     /transl_table=11
                     /translation="MPTNGRHAVGAGALLAILRDGQPRTRGELARLTGLSRSTVSQRLD
                     ALIGSRWVVEDEGAISSGGRPASMFTFNGGARVVLAADLGATRARLAVLDLGLDVLAEQ
                     VTGLPVDLGPEPVLGAVATSLRHLLATAGRDPAQVCGVGIGLPGPVEHRTGRPVNPPIM
                     PGWDGFPVPERLRELLGERPKERPGDQPRDRPGEWPGAPVLVDNDVNVMALGEHWAARP
                     AVDHLIYIKIGTGIGCGIISGGRLHRGARGAAGDVGHIRVPASGAPCRCGNTGCLEAVA
                     GGASMAAALREAGADARGSKDVVALMRAGDPLATRLVRQAGREVGTVMAAIVNFFNPSV
                     IVLGGDVAEAGEQLLAGVRETIYSRSLPLATQHLGIRTGELGDRAGVVGAAVMVVEHVL
                     DPATIDEATGERPACIAAR"
     gene            20141..21394
                     /locus_tag="BKM31_RS06055"
                     /old_locus_tag="BKM31_06035"
     CDS             20141..21394
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015297 - antiporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020544833.1"
                     /locus_tag="BKM31_RS06055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKM31_06035"
                     /product="cation:proton antiporter"
                     /protein_id="WP_080037181.1"
                     /transl_table=11
                     /translation="MSTLDLILALGGAAALLAAILPEFLARRALSLPLVYLLAGILLFT
                     LPLGLPDPDPIAHRVALEHITELCVVISLMGAGLAINRRIGPRGWSTTWRLLALAMPLT
                     VAGVAAAAVALPGWPIAAALLLGAVLAPTDPVLASDVHVGEPVDAQNADDEVRFALTSE
                     AGLNDGLAFPIVYAAIAVAAGTAGWAGEWALTDVLYRTAAGALLGLLIGGLLGRLFFRA
                     RSDGLRLAERRDGFVALACTFLAYGVTELAHGYGFVAVFVTACAIRSAEHGHGYNNVLH
                     GFVEQIERLLTAWLLLLLGGFVATGGLAALTWRGAAVGLLLLLVIRPLAGWLVQWRGRA
                     GPRERLAISFFGIRGIGSLFYLAYALGQADFGVPAEELWAVTGFTVLASVVLHGVTATP
                     VMNHVDALRKAHLGRGGR"
     misc_feature    20282..20284
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    21750..21764
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.75"
                     /tool="antismash"
ORIGIN
        1 tagccgtgcg cccactcgaa gttgtccatc agcgaccaca cgaagtaccc gcgcacgtcc
       61 gcgccgcccg cgatggcctc gctgacggcc gtcaggtggc ggtgcaggta gtcgatgcgg
      121 tcggcgtcgt gcacgacgcc gtcctcgccg accgggtcgg ggaacgcggc gccgttctcc
      181 gtgatcatca gcggcaggtc cgggtagtcg cggtgcaggc gcagcagcag ctccgtcagg
      241 ccggtctcgt cgatgttcca gcccatctcc gtgtacgggc ccggctgctt gacgaactcg
      301 atgtcctcgc aggcgatcca cggcgaggcg gcgccgtcct ggtgcccgtc ggccgtctcc
      361 ttcgccgagg cgccgtccca ctggcggacc agggtcgggt tgtagtagtt gacgccgagc
      421 acgtccagcg gctggcaggc ggcggcctcg tcgccgtcgc gcacgaacga ccagtcggtc
      481 accgacgcgg tgtcggcgat gaggtcctgc gggtaggcgg cctccagcat cgggccgagg
      541 aaggcccggt tggccagcgc gtccgcgcgc cgcaccgcgt ccgcgtcgcg ctcggacacg
      601 ccgcgcacgt ggtgcaggtt gagcgtgacc gacatctgcg cgtccttggc ggcggtcgag
      661 cgcagcgcct gcaccgcaag gccgtggccc aggttgaggt ggtgcagggc ggccagcgcg
      721 gcggcggcgt cggtacgggc gggcgcgtgc acgccggagg cgtagcccag gtaggccgag
      781 caccacggct cgttcagggt gatccaggtg cggacgcggt cgcccagggt ctcgcccatg
      841 agccgggcgt actcggcgaa acgcagcgcc gtctcccgcg ccggccagcc gcccgcgtcc
      901 tccagctcct gcggcaggtc ccagtggtag agcgtggcga ccggggcgat gtccctggcc
      961 agcagcccgt ccacgagccg gttgtagaag tcgacccccg gccggttgag ctcgccgcgc
     1021 ccgcccggct gcacgcgcgg ccaggagatg gagaagcggt aggcgccgac gcccaggtcg
     1081 cgcaggaggt cgaggtcctg ctccaggcgg tggtagtggt cgcaggccac gtctccggtg
     1141 tcgccgttgg cgaccaggcc gggcgtgtgg gagaaggtgt cccagatcga cgggccgcgg
     1201 ccgtcctcgt tccaggcccc ttcgacctgg taggcggcgg tggcggtgcc ccacaggaag
     1261 ttctcgggga aggcaggcat gtcactcctt ggcactgagc gtgatctcga tgtggtcgat
     1321 ctcgggagcc gcggcggcgt gcgccgcggc gtgtcggagg ttccaggggg cgggcgcgcc
     1381 gctcaggcgg cgggcccgca gccggtcgcc gtggcgggac acctcgaaga cggccgcggg
     1441 cgtgccgtcg agggcgggga cggtgacggt acggctgtcg ccgtcggcga accggtaggc
     1501 gtcgagggtg acgccgtcgg cgtagtcgta gtcgggccgg tcgtcgcggg caccggtcgc
     1561 gatcaccgcg cccggccgca ccagcagcgg caggctgtcg aacccgtgcc gctcgcggcg
     1621 ccacccgggc ccgctcacgg tcgtgccgtc gagcagccgg gtccacacgc cctcgggcac
     1681 gtagtacgaa acctccccgt ccgcggacag cacgggagcc accagcagat cggggcccag
     1741 caggtactgg gcgtccaggt ggtcgcagcc ccggtcgtgc gggaactcca ggtgcatggc
     1801 ccgcatcatc ggcagcccct cggccgcggc ctgcacggcg gcgccgtaca gatagggcat
     1861 cagccgcgcc ttgagccgcg tgaacgcgcg cagcacgtcc accgactcct cgtcgaacag
     1921 ccacggcacc cggtacgacc cgctgccgtg cagccggctg tgcgacgaca gcagcccgaa
     1981 cgccacccac cgcttgaaca cggccggatc ggggcgcccc tcgaagccgc cgatgtcgtg
     2041 gctccagaac ccgaacccgc ccagccccag cgacagcccg ccgcgcagcg actcggccat
     2101 ggcctcgaac gtcgactcgc agtcgccgcc ccagtgcacc ggcagccgct gcccgcccac
     2161 cgtggccgag cgcgcgaaca gcaccgcctc gcccggcccg cgccgctgcg ccagcacgtc
     2221 gtggacggtc tggttgtaga gcaggctgta gtagttgtgc atccgctcgg ggtcggagcc
     2281 gtcggcgtag acgacgtcgg tggggatgcg ctcgccgaag tcggtcttga acgcgtccac
     2341 ccccatgtcg agcagccccc gcagcttgcc cgcgtaccac tcgcgggcgg cgggcgaggt
     2401 gaagtccacc agcgcgcgcc cggcctgcca gtggtcatcc tgccagaccg tcccgtccgg
     2461 acggcgcagc aggtgcccgg ccgcggcccc ctcctcgaac agctccgacg cctgcccgat
     2521 gtacgggttg atccacaggc acacccgcag gccgcgctcc ttcagccggc gcagcatgcc
     2581 ctccgggtcg gggaacacct ccgggtccca cacgaagtcg caccagcgga agcgccgcat
     2641 ccagaagcag tcgaagtgga agacgctcag cggcaggtcc cgctcggcca tcccgtccac
     2701 gaacgaggtc acagtggcct cgtcgtagtc cgtggtgaac gaggtggaca gccacagccc
     2761 gaacgaccac gcgggcggca gcgccgggcg gccggtcagc gccgtgtagc ggcgcaggat
     2821 gtcggccggg gtcggcccgt ggatgatcag gtactccagg tcgtggccct cggcgctgaa
     2881 ctgcacccgc gacaccgtct ccgagccgac ctcgaacgac acccggcccg gatggttcac
     2941 gaacaccccg tagccccggt tggtgaggta gaaggggacg ttcttgtagg cgatctcgct
     3001 gctggtgccg ccgtcctcgt tccagatgtc gaccgactgg ccgttgcgga cgagggggcc
     3061 gaagcgctcg ccgagcccgt acaccagctc gccggcgctc aggcggagct gctcgaccat
     3121 gaagtgccgc tcgtccgggt cgcgcatgag gcccaggctc ttgcccgcgc tgcgggtcag
     3181 ctcccgcccg cccgcgctga acgtcatctc ccagggcgcg tccctgcgca cccggaccgt
     3241 gaggtcgccg ctggtcagcg ccgcctcctc gccgtccacg gcgatcttca cgtcgggccg
     3301 gtcgtcccgt acgccgaagg cgggggaggc gggcaccgac ccggcgaagt gcaccgtgcg
     3361 gacccggatc acgtccggca tcggcgagga caggtccacc cgcaggaccg gcccgtcgat
     3421 ggtgtcgccg cggcgggcga tctcccgcgt cggggccagg acgcgcagcg tgccgtcccg
     3481 tacggtgacg tcgaaggccg cggtcgcgta gccggcgcgc acgccggggc gcaggcgcca
     3541 gtagccgtcc ttgaacttca tgccgcggga acctcctggc gcagcgcggc gaccgcgcgg
     3601 ggcgtcagcg tgacgtgacc ctcggcgcgc gcgccggtca gcaggtcgac gcccggcttg
     3661 gggatcggca cgcggaccgt cgtcgcgccg tggttgagca ggaacagcac cgtgccgcgg
     3721 cgcaccgcct ccacgcccgc cggcaggtcg ggcagcgggc cgcgcacgcc cgcgtcggcc
     3781 agcgcccgcc cggccaggct cgccagcgcg gccggctccg gcatcgtgcc gacgtaccag
     3841 gcgacgcccg cgcccgagcg gtgccgcagg atcgccggcc gccccgccag gtcaccctcg
     3901 gcgaactcgg ccaccacctc ggcgccgtcg gcccgcagca gctcggtcca ggtgtgcgcc
     3961 tcgaagtcca ggccgccgct ccaccggcag cgcaccggct gcccggcggg cagccactcc
     4021 tcgccggagg cgcccagcac ctcgcgcagc ggcaccggga accgcccggt ccgcacgtgg
     4081 gagttctcgt ccaccacgcc ggagaacggc ccgaccacca gcacgccgcc gccctgcacg
     4141 tacgcggtca gcgcggccgc gtcccggtcg ccgagcagga acaggttcgg caccacgacc
     4201 agcgcgtacg ccgacaggtc ggcgcccggc ggcaccacgt ccacgctcac gccgcgctcg
     4261 aagaacggca cgtagtagtc caggagctgg tcgaccgcgt tgagccggtc gctgggccgg
     4321 ccgcggtcct ccagcgccca ccagctctcc cagccgaaca ccatcgccac ccgcgccggc
     4381 accggctcgc ccgccacctc ggccagcccg cgcagctcct gcccgtgcgc gcgcacctcg
     4441 gcgtgcagcc gcgtgtccgg gcccgcgtgc ggcaccatcg cggcgtggaa gcgctcggcg
     4501 ccgaaccggg aggcccgcca ctggaagtag cacagcccgt ccgcgccgcg cgccaccgcc
     4561 tgcagcgact ccaggcggag ctggccgggc ggcttgggca ggttgtgcgc gcgccagttg
     4621 accgcgctcg tcgcctgctc catcagcagc cacggccgcc cgccggccag gccgcgcatg
     4681 aggtcgtggg tgagcgccgt ccgcgccggg gtgagcgggt tccccggctc cgggtagcag
     4741 tcgttggaga tcacgtcctg gtcggcggcc cacgaccagt agtccacgcg cttgaagaag
     4801 cccatgaagt tcgtggtcac cgggatgtcc ggggtgtggg cgcgcaggat gtcgcgctgc
     4861 tcgcggaagt gcgcgcgcag ctcgtcggag cagaagcgcc accagtcgag ccgctgggtg
     4921 gggttgatga tgtacggggc gcggcgcggc ggcaccacct cggcccagtc gccgtacccc
     4981 tggctccaga acgtggtgcc ccacgcctcg ttgagcgtgg ccaggtcgcc gtagcgggcg
     5041 cgcagccagc cgcggaacgc ctccgctgac acgtcgcagt ggcagacctc gccgtactcg
     5101 ttgcccacgt gccacatggc cagcgccgga tggtccgcgt accgctcggc cagcgccgtc
     5161 gtgatcgact gggagcgctc ccgatatggg cccgaagaag ggcagaactg gttgcgggag
     5221 ccgtaccaga gccggtgccc gccctcgtcc accggcagcg tctccggcca ccggtgcccc
     5281 agccagggcg gcggcgacgc cgtcgggacc gccaggtcca ccgcgatgtc gtgcccggcc
     5341 atcaggtcga gcacccggtc gagccagccg aagtcgtgct tgcccggctc cggctccagc
     5401 cgcgcccagc tgaacacgcc caccgtgacc aggttgaccc cggcggcccg catcagctcg
     5461 gcatcctccc gccacacctg ctccggccac tgctccgggt tgtagtcccc gccgaacagc
     5521 agcccgcggc gctcggtcag cgcacgcatc cccggcctca ccatcttccc ccttcacgag
     5581 gtggcgcgga gctgtccccc accaccagcc ggcagggcag cagccgccgc tgcggcccgc
     5641 cctgtgtctc gccttttgct tcgccctgtg ttcggctctg tgtctcgccc tgcagcttgt
     5701 cgatcaacat gcgggcgccg atccggccca gctcggcgct gggcggctcc agcgtcgtca
     5761 gccggggatg gaacatcccg gccacccgcg ccgacgacag caccagcagc agcgtcagat
     5821 cctccgggat gcggcgcccg agccgcgcca cggccgcgat caccccggcc gccgcgtggt
     5881 cgtccatcac ggccagcgcc gtcacgtccg gatgcgcgcc gagcagctcc tcgaacgcct
     5941 tcccgccctc ctcggccgac cccggccggt acccaccgac gtactgcagg cccgcctcgc
     6001 gcgccgcccg ctcgaactcc cgcccggcgc gcaccgcggg cccgtacccg gcggcgtgcg
     6061 cgtccacggc ccggttgaag aaggccagct tgcgatgccc cagccccgcg acgtgcgcca
     6121 ccgccgcctc ggcggtggcg gcgaagtcga tgtccacgtg atcgatcccg cccggctcgc
     6181 gggtccgccc gatcatcgcg aacggcaccc ccgcctccgc cagcaccgcc ggccgctcgt
     6241 cgtccagccc cacctccatc agcagcaccc cgtccaccag ccccaggccg gtgatgtgcc
     6301 gcaactcctc gatggggtcg gcgctctcgg gcgacagcag caggtgatag ccccgctcct
     6361 tggccgcctc ggccgccccg gtcgcgaact gcatctcggt cagcccgaaa ccgctgcgcg
     6421 gagcggggaa cagcagcgcc aggatccgcg tccgcttgct ctgcaacccc cgggccagca
     6481 gattgggccg ataccccagc tcggctgcgg cccgctcgac ccgccgccgg gtggccgccg
     6541 ccacggggcg ggtgccgttg agcgcggcgg acgcggtact gacggccacc tgggcacgct
     6601 cggccacgtc acgcagagag gtcatgaggc tccgggggcc gttatggcgg gtcgaaacgt
     6661 ttcgcaccac gctaaagtcc ggtttgtggg gatgtcaatg gggtgattac gggcagccgg
     6721 aaccagcgta cgggtgtggg tcgtgccccc gtccggcgtc ctgcccggac gaggggcttg
     6781 cgcgcgcctg gagaacgtgg agcggctcac gcggaggtgg cgattgtccg gcatgcacca
     6841 ctcaaagaga ggcgcaatgc ggacaaatct gcaatgactt gacagacccc acttttagga
     6901 cgacccatgt atataaccct ggagggcatg gattccggag caattatctc cgaggtttct
     6961 tgtgttggta tgccacactc tctcgaaact gccgcgagat ctcccggaaa ctgccacgat
     7021 gggacgcgct cgcatcccgg cgagagtcgg tgaccttgtc cgatacccga acggagacca
     7081 gccttgccag gtgatcaggc ctcttatcga ccggctcgat taggtttcgt cgggatcgat
     7141 gccggaggca ccaaagtgca cgttcggtat cagctcacac ccgcccacgc cgccgagacg
     7201 ttcaagatac gttcggccga ttacgactcg ctcgacgatc tcatcgaaga ctgcctgaaa
     7261 aagatcggat accttccccg cgctctggtc gcgggggtcg cagggcggcc acggcccaat
     7321 ggagacgtcc gggtcacgaa tcaaccgggc tggcccgtat tccagcgtga tcggttcgcc
     7381 gccgttcgcg gcgtgcgcct ggagatcgtc aacgacatga tcgccacggt ggccggagtt
     7441 cgcgagctca cggtggcgga atgccgctcc ctcacccccg gcatcgccct cagtgccccc
     7501 tcgcgactcg tggtggcggt ggggaccggt gtgggcgtgg gctacgcgga cggagagggc
     7561 cgccctcacg gtacggaggc cggtcacatc ccctggcagc ccgtcggtgc cagggagggc
     7621 gactatctgt gctggttgca ggggcgccac cccggcgtac ctatctcggt cgagcagtcc
     7681 gtcgccggcc tgcacgggat cgagcacctg tacgactacc tgtccacggt gcgcccgcct
     7741 gctcggcggc tgagcgaacg cgtcggccgg gcacgtgtgg aagggcaggg catcggcgcg
     7801 ctggtcatgc ccgaggcggt ggcgggcgac ccgttctgta ccgagctggt ccggttgctc
     7861 ggcgtgatcc ttgggcagtt cctgcgctcc atggcgctcg tgacgttgag ccagggcggc
     7921 tcgatctggc tggccggcag cgtgctgcag tcgccggggc tggccgagct cctggtcgcc
     7981 gacgggtgcc tgctcgaagc gttccgcggc gggggtgcgc agcacgccga cctcatggag
     8041 cagataccga tgttcctcat tctcgatcac gagatcgcgg tcaaaggcgc cttggcgctg
     8101 agcaaggcgc tggcggcatg aagcgagatc agaaaatgcc cttgagttcc ttttcttcca
     8161 accagtcacc gtggtgaagt gtgccccagc ccgtcagata aaaattccag gccgtgcgat
     8221 atgaagcgat attgccgctc tcgcggcagg acggatacaa ttcgaacctt ccccctcttg
     8281 gtcggggagg tcctgttgac ccacatgctc gacctgctgt cgccgccacc cgctgccagg
     8341 gatcgcaccc gcctggagat catcaaggcg atcatggcga agcccgacac gcagcagcag
     8401 ctcaggcggc gcacgggtta ttcggcggcc accatctcgg gcgtggtgcg caagctgcac
     8461 gaggacggac tcgtcgaact cgtaggcgcc agcgagctca acaaggaggt caggctcctg
     8521 ccgctcgacg gtgtcgccgt gggcgtcgag gtcggattct cgaacatcgc ggtggtcgcc
     8581 cggcgcgcgc accagagcca cagcgacgcc cgctgggggt cgagccaggt cagtgcggct
     8641 cccggcgagg ccgcgtggct ggacagcgcg gtcgcgctga ttcgcgaggt ggtggaggaa
     8701 gtgggccagg ggcccgagga catcgggacg gtcggcatgg gcatccccag gatgatcgat
     8761 cccaagaccc agcggttcgc cccgcccgtc ctcgcgccct ggcaggacgg agaggacccg
     8821 gccgcgacgc tggccggccg tctcacccgg cgcgcaggga aagagcgcgc gggcatgtgg
     8881 aaggtgcgtc tggacaacga cgccaacctg ggcgcctacg cggcgagcgt ctaccagtat
     8941 ccgctcaagg aaacgctgat ctacatcaag gcgtcgaccg gcatcggcgc cggcatcgtg
     9001 atcggcggta acgtcttccg cggcgccagg ggctgtgccg gggagatcgg gcacacaccg
     9061 gttcagcaga acgggcgata ctgcctgtgc ggtgggcgcg gctgcctgga gacggtgatc
     9121 ggcgccgacg cgatgctcca gaacgtcaag acccacctcg gcggccggcc gttcgaggcg
     9181 cccaggagca tccgcgagct cattcgctcg gccaaggacg ggaaccccat ctgctcgcga
     9241 gtcctgcgcg aggccgccga gcaactcggc cacagtctcg gcggcctgtg caatctgctc
     9301 aatcctgaag tgatcgtgct gggtggcgcg ttcggccggg ccggagcgat cgcccgcgag
     9361 gcctgtgagt cggggatcag gaggacggcc atggccgccg tcgtggacgg tctgaccgtg
     9421 gccagcagcg agatggagca cagcagcgcg cacggcgcac tcctgatggg catcgacggg
     9481 gaaggtctct agagaaccac ccttcaattt gaagtggcct tgtcgtgatt tgaaagtcat
     9541 atggtgacgt caatgtgagg atctttgtca attagcatga cgtccgtgtg cgtgacattc
     9601 acaaaaccgc ttccaatgac ggctgccgga gggttatcat gcctatacat ccgggtggtc
     9661 gtgtgcagac gaaggggatg agttcattaa cgtctggaga ccttatgaat aagccggaat
     9721 ctgcgcccac ccattcttcc gagtcggtca cggagctgtg cgaggcggca ggcctcgagg
     9781 cttctgggcc ttcttgctac acgacgcctc gcgtcattga tctggggcct gtgaagaggc
     9841 agaccaaagg gagttcgtcg aacggcacgg ccgacgcgaa ctcccagtac tactggggtt
     9901 gaaagtggag gggccaggcg atgacggccg gcgtcaggag ccggtcgcgg cgccacccgg
     9961 gttcatcgtc actctcacac aggggcgaga acgggccagc gtgcggttct acggcacctg
    10021 gccggacggc gagcgggtgt gggccgagca tcccgaggcg agcctgctgc tcgtcgggca
    10081 ctgcctggcc cgcccggccg acctccggga cggcctggcc gccgcattgg aacgtgacga
    10141 gccgcgcctg ctcatggact ggccgggagc ctacgccggg ctgctcctgc ggcaccgcgg
    10201 ggaggtcatc gccttcaccg acctggcggg ccagttcccg ctctattaca ccagcgcccc
    10261 cgacgagctc gcgatcgccg cacaccccga ggtgctgacc gggccacgac agcgggcact
    10321 ggaccgcgtc atggttgctg ccaggatcgc ctgccccgcc gtgctgccgc tctgggagaa
    10381 ccgctcgccg ttcgagaccg tcgcccggat gcccggcggc gcggtgctgc gcgggcggcc
    10441 aggggaggtg cggctcagcc cgccgctcct acgggccgcc gacctcgatg aggtagacgc
    10501 actgcgtgtg gcgctcaccg aagcggtggc tctccgctgc gccgacggcc cggtctccgc
    10561 cgacttcagc ggcggcctcg actccacctc actcgctttc ctggccgcgc gccacacgtc
    10621 tgtcgaggcg gtcgtctacc accacccgca ggtgccggcc gccgacctcg ccgaggccgt
    10681 cagcttctcc caccacgacg agcgcatcca cctgagcacc gtgcagggca gccaagacac
    10741 ccttccctac gcagcactgc cgcagcaggc gggccggacg tcgcctgggc agcgaggtgc
    10801 cgagcccacc agggggagcc tggcggtgag gcgcgcgatg ctccgcctgc ggcacgcgaa
    10861 gacggcagag acccggctgc acatcaccgg cgaaggcggg gacgcgatct tcggcgcggc
    10921 gccgtcgtac ctgggcgagc tggcccggca cgggcacctg cgccgcctcg cccgccactg
    10981 cgccggtcag gccgcactgc gccacacctc cacgctggcc ctggccatgc gggccgggcg
    11041 gctggcgctc accagcccgg tcgccgcgct cgcccggctg agcagacggc tgctgcggcc
    11101 cgaccagagc gagctcacct ggcccgacgc catcgcctgg tggccggtcg acggtgccgt
    11161 cctgacctgg ctgacccccc tgatgcgcgc cgaactggcc gaagccgtgc gtgatcccgg
    11221 cctggccgag tgcttggcgc ccgacggtgg ccccgcgcag atggccatgc gtaccgagtt
    11281 gaggctgtcg gccgagtcgc agcgccatct ccgcgatctt ggcgcgctcg acgggatccg
    11341 cgtgcacgcg cccttcctgg acaacgccgt ggtcgcagcc ggcctcgccg tgccctccgg
    11401 ccgccgcggg gaccccttca ccagcaagcc gctgctggcc gccgcgctgc gcgggctggt
    11461 gccgcaggca gtgttccgtc gtcgcacgaa aggcgactac agcgccgagg agtaccacgg
    11521 cgcccgggtg gccgcacgcc acctgtacgc cctgctcgac gactcccgcc tggtggccat
    11581 ggggatcatc gccgccgaac ccgtccgcgc ctgtctgggc cgcctgctcg ccggagcgcc
    11641 ggtgccgctc ggcgcgatga gccagctgtt cgccacggag aactggctcc ggtgcctgga
    11701 aaaccccttc gattggtcgt gacgcatgct gcagcttcgc atcccggacc atgtccacca
    11761 ccagacgtac gggcacggcg gagtcgtcct gctcaacgtg tccaccgggc agtggcacgc
    11821 gctgaacgac acggccgcgc acctgtggat cggctgggcc ggcggcgccg ggttcgagga
    11881 gagcatcgcg caggtcgccg gtcgctatcc cgcgaccgcg cccgacatca tcaggcgcga
    11941 cgccaacctg ctcctgcgcg acctggtcaa tcgtggcctg atcgaaaccg atctgtccga
    12001 cctgcggatg gcggccacca tggcggggcc ggagcccggc tgcgcggctc gcgtgccctg
    12061 gcgtgagcgg cttttcgccc tcggcagcct gctgcttgcc gtcgtcctgc tcaaactgcc
    12121 cttccgcgcg accgccgggc tccttacccg gatgcgcggc aggtggtgca ggagcgagct
    12181 gcccgccgat cgcgcggaga ccgcggcggc ggccgtccgc catgtggccg actggtaccc
    12241 gggccggacc gcctgcctgg agatctccct ggccacggtg ctctccgcgg cgttgcggcg
    12301 ccggcggctg gactggtgcc tcggcgcgat caccgacccc taccgcttcc acgcctgggt
    12361 ggagatcgac agccggccgg tcgccgccgt gcacgagccg gcagatcccg gctatctccg
    12421 tgtgctcaca ttgtgagcct gaggcgtgca aatcgaacgg gtcagcgccg ttatccatgg
    12481 gcgacggccg ccatttgata agttccccgg gaaattccga aacgctgatg cagcgaatag
    12541 ccggcgcccg aagaatggtc catcgttacg cgaaagaatc gttggattcc gggatgcgga
    12601 acggctaggc tcggaaaaga gagagcccgg cgaggcccat cggctccaca ccacgggccc
    12661 cgccgagccg ccacccaacc ccgaagggag ggcagtccat gcggagatcg gacagccgtg
    12721 tggagtttga gatcaagggg aggttgcgag cacctgactg gcgctggctc ctgctcctcc
    12781 tcctcgccgt gctgatcgtc gtcctcagga cggacggcga cggcgtggtg atccaactgc
    12841 ttccgtgaac gactatcccg ggccgctcac cgatccggtg ggcggcctga cccatgtcgt
    12901 tcgcgtacac gagcctccag ccttccccga cttgttgctg ccatcatacc gcagtcttta
    12961 aaatatgaaa gcccagtcgt tcagttaatg cgttcccgcc gcgcccgtaa cgacaaggac
    13021 atgaaaacaa atcctcgtcg acgtcagcgc gtacgggtat ctcagcattc ccgcgaacgg
    13081 ctttcacgca tgagggcact cagtacacgt acggccagcc ggccgagtcc cagccgatga
    13141 ggttgacgcc gagcttcggc gtgccgcccg cgttgccgtc gtagtagtgg tagacgagca
    13201 ggtcgccgtc cacgtccgac atgacgctct gcccgccggg gccgatgatg gcgccgtggg
    13261 tctccaggac cgtcgtgccg ccgccgttca gcatcggggt gcccgcgcgg tccgtgtacg
    13321 ggccggtcgg gctggtcgag cggccgacct tgatcttgta cgtgctggac gtgccggcgc
    13381 agcaccggtc gtaggaggcg aacaggtagt agtaggtgcc gtggcggatg atgtcggggg
    13441 cctcgaccgc gtagggggcg tcggggcggg tggccaggtg gtagagggtg cggtcggagg
    13501 agtggcgctt gccggtcgcg gggtcgaggc ggatcatgcg gatgcccgtc cagtacgagc
    13561 cgaagctcag ccaccaccgg cccgaggcgt cgaccaggag gttggggtcg atcgcgttgt
    13621 ggtcgttgct ggtcgtggtg gcgtagacga cgccctggtc ggaccaggtg ccgggctggc
    13681 cggtggagct ggtggccagg ccgatggcgg agttgttgga gccgaagctg gagacggcgt
    13741 agtacatgag gtatctgccg ccctgctggg agatgtcggg cgcccagggg tcgttggcgg
    13801 aggagtacgt ccgccaccac gacggcggcg tgcggaaggc ggagccggcc cgggtgaagg
    13861 tgatgcggtc ggtggaggtg cgggcctcca ggtagccgtg ggtcgagtag agcacgtagt
    13921 tcgacgaggt gcggatcatc gtggggtcgt gcacgacgac gtcgccggtg acccggccgg
    13981 ggttggggta ggcgagcgcg gcggccgtga gcgcgagcac gctcgcggcg gcggcgacga
    14041 tgcggggcag gcggcgcaag ggtcctcctt gagggggtgg gacgctgcgc cggtgcgtcg
    14101 caggcaatgt aggtgcggtt ttcggagatc gtcaacccgg tcgtgaaact tacacggggg
    14161 tggtggggtg agctgcgggg atgtggcggg ccggcggtcc gggtcttgac aggactggtc
    14221 agggttcgta cggtcgggcc gctttcgatc ggcgatgtta acgctaacaa tcggaggctg
    14281 cgccgcgtca ccctttccgg ccgggccgtt cggggcccgg ccggttcccc ggcccgagga
    14341 ggttcaggac acgacgcgat accagatgtt cacggcgtgc ggcacgtggc cggcgcgcag
    14401 gcgttcgagc ctgacgttcg tgccgcccgg gtgctcgaac aggcgcaccc cgtccccgag
    14461 cagcaccggc gccacgatcg tcagcacctc gtccagcacg ccggcctcca ggcactggcg
    14521 ggcgacgtcc gcgccgagca cgttgacgta cttgccgccc gcggcccgct tggcggcggc
    14581 cacggcggac ggcaggtcgc cggcgaacgt gacgcccggg accgggtcgc cggggacgtg
    14641 gtgggtgagg acgacctgcg gcccctgcca ggcgccctcg aacgcgccct ccttgtccgt
    14701 gcccttgttc gggtcgtcgc cggcgtaggt gcgcctgccc accagcagcg cgccgatctc
    14761 gccgacgagg tcgtcgacca gcgggttcgg gccgaggtgg ggggtcagcc aggacatgtc
    14821 gccgcccggg cgcgcgatga agccgtccgc cgacatggtc accgagtaca gcagtttgct
    14881 catgaccggt agaccgccag gtgcccccga agtcatcggc tcgggggagc ggcgcggaag
    14941 gacgcctcgc cgtcgccggc gcggttctcg tgcgtggcgg gcaccaattc gcccctgacg
    15001 cgcggggatg cagggtcacg ccgtgacgcg cgggtcccag ccgagctcgt cgtagaaggc
    15061 ggcgcgcgcc cgctcgaacg cggcccgctc caggacggcg ccccggtgcg gcccctccgt
    15121 gatcgcctcc tcgtgcaggc gcgccggcag cgtctcgtcg aggtgcccgc cgctctcgcg
    15181 cagcgcgtac gcccgcatcg cgtccagacg ctcctgaccc accgccagca ggtcctccag
    15241 cgtgaactcc acgcccagca cggccctgac cagcgccgtc aggtggtcga tcgtgagagg
    15301 acgggtcggg ctggaggcga acaggcacac gttcagcgcg tccaggccgc tccacaaccg
    15361 cagcagccgg gctgtgcgcc ggccccgctc ctcgtccagc tcgcccgccg gggccggcag
    15421 cgccccgacg cgcgccgcct cgggaaagca gtaagccagc cccacgaccg ggtcgaagtc
    15481 gaggtcgtgc tccagcgcgt cgtaacgcgg gccgcccgga gccagcgcgt agccgaggcc
    15541 gatgcccggc tgcgggcgcg ggtcgatgca cggcacctcc gcgtccttca ccgtcatcgc
    15601 gtacgccgcc gcgccccgcc cgatccgccg cgccgcccgc gccgaaccct ccgccagcag
    15661 gtcgcccagc gcgtccgacc gcgcggccac gtcctcgatc aggcccggca gcgccgccgc
    15721 gtccccgaac gccgggccac ccggcagcag gccacgctcc gcgcactcca tcgcgaacgc
    15781 gagcgtgccg cccagcgaca ccacgtccag gccgagatcg ttgcagcggg cgttggcggc
    15841 caggatggtg tcgaggtcgt cgatgccgag attccagccc agcgacacga acgcctcctg
    15901 cccgagcccg cccgtccgcc gctccacccc gggcggggcg tacaccttga ggcagtcgtt
    15961 cgggcagccg gggcacgagc cggtcgtcgc gaccgcgcgg ccgtcgtagt cgcccgccga
    16021 cggcgcccgc aggccgggcg cccccgtcac ggagaagttg cggaccgagg cgtaacccgg
    16081 gtcgatgggg tcaccggccc acgccgcgaa acccggcaga cccgcctgcc aggcggccag
    16141 tttgtttgtg accatcgcct cccggtagta ggcggtcagc gcggcgatcg cctccggatc
    16201 ggccaccggc gccgggtcgc ccagtccggc gcgcgccgcc gccgtctggc cggccggttc
    16261 gccgagtgcc gccaggtcgg ccaccgccac cgggtcggcc cgttcggcga gcgccacccc
    16321 ggccggggcg gggccggcgc agacgatcgc cttgaggttc ttggcgccga agaccgcgcc
    16381 gagcccgtac cggccggcgg cgaacgcgtg atcggtcacc acgctcgcgt accgcaccag
    16441 atgctccccg gccggcccga tcgccgcgac gtgcgccccc gcgccgtgcc gggcgcgcaa
    16501 cgcgtcggtc gtcgcggccg tgcccagccc gcgcaggtcc tccgcgccgt gcacgctcac
    16561 ctccccgccc gccaccagca ggtacgacaa ccgctccgcc cgccccacca cggccagcgc
    16621 ctcagccccc gccccgcgca tccccgccgc gaacgggccc agcgcgtgcg cctccccggc
    16681 cacccccgtc agcggcgact tcgccaggaa caccgccttg gccagccccg gggccgccgt
    16741 cccgcccagc atcccggccg cgacgtacag cagcgtctcc ggatcgtacg gatccagccc
    16801 cgccgccgtc cgctcggcca tcagccgcaa ccccaggatg gagccgccgt agtgcccctt
    16861 ctccgcggac cggtcttcct tcgtcacgtt tccgctggtc agatccacga tgaacggcat
    16921 gagacagcct cctagggcca ggaaggggac caggagcggc acaccatcac acatctcccc
    16981 gcacccgcaa ccctcgcccc tggacgggcg gctcccttca caacatcatg agacgggggg
    17041 ttaacggatc agtcagaagg agctgtccga ccatggccac cgtcatcgca ctcgccaccg
    17101 ccgccctgtt actcaccacc acacccgcga tcccgcccgc cacctcggcg tccggtgagc
    17161 gacctgccgc ctcggcgtcc ggtgcgcgac ccgccgcctc cacgaccggt gatcggctcg
    17221 tcgcccgcac cgagtccggc ctggtgcgcg gggcgcgcgc cgacggcgtg gagcgcttcc
    17281 tcgccctccc gtacgccgcg ccgcccgtcg gcgacctgcg ctggcgcgcc ccgcagcccc
    17341 cgccctcgtg gaagggggtg cgcgcggcgg acgcctgggg caaccgctgc ccggccgccg
    17401 cgagcagcaa cggcccccgc tccgagaccg aggactgcct gtacctcaac gtgttccgcc
    17461 ccgagggcac ccgggccggg cagcggctgc cggtgctgtt ctggatccac ggcggcggcc
    17521 tggtcaacgg ctcggccaac cagcacgacg gcaccctcat cgcccagctc gagaacgtgg
    17581 tcgtggtgag cgtcaactac cgcctcggcg tgctcggcta cctcgtccac ccggccctgg
    17641 ccgccgagtc cggccaggcg ggcaactacg gcctgctcga ccagcaggcc gcgctgcgct
    17701 gggtgcggcg caacatcgcc gcgttcggcg gcgacccgcg gcgcgtcacc atcgacggcg
    17761 agtcggcggg cggcttctcc gtctgcgccc acctcaccgc ccccggctcg gccgggctgt
    17821 tcgcgcgcgg catcatgcag agcggctcct gcgtcagccg tcccctcgag gacggcgagc
    17881 ggacgggcac ccagatcgcc accacgctcg gctgccccga cccggccacc gccgccgcct
    17941 gcctgcgggc gctcccgccc ggccgcctca tcgacggccc gcagtacacc tccttcacgc
    18001 acggcacgcc cgccctcccg gagagccccg acacggccgt gcgggcgggc cgcttccagc
    18061 gggtgccgct gatgatcggc tacaaccggg acgagggccg cacgttcctc cagggcaacc
    18121 ggggctggac gcgggagcgg tacgaggagt gggtgcgcac cgtgttcggc gaccgcgccg
    18181 ccgccgtcct ggagcgctac ccgtggccgg cccgctccga cacgttcacc tcggcgtacc
    18241 tgacgggcgc gatcgccacc gacgccggcc ttctcgcggg catcggcggc tgccccgccc
    18301 tgcgcctggc gcgcgacctg tcggcgtaca ccaccgtcta cggctaccgc ttcgaccacc
    18361 gcaccggccc cggcctcacc cccgagcccg ccgggtacgt ctggggcgcc gggcacgcgg
    18421 cggagctggc gtacctgtgg ccgagcttcg acaacggcac cccgatcgcg cccacgttcg
    18481 acgcgggcga gcgccggctg gcccgcgaca tggtgcacta ctggggcggg ttcacccgca
    18541 ccgggcagcc gtacgccaag gggtcggccc gctggccgcg gctcggcgac gcggtcatgt
    18601 cgctgcgcgc ggccggccgc tccacgccgg tcccggaggc gacgatggcg gccgagcacc
    18661 agtgcgacct gtggcagccc ggcagcgcgg gaagttcgta ggaggccgca cgtcctcggg
    18721 aagcggcgca tatgtccccc gacattcgcg gacgaccaca ccgactttta cttctcatca
    18781 acataagtcg gccgatattc gaagtaaggt agatccatgc caaccaacgg ccggcacgcg
    18841 gtgggggcgg gggcactgtt ggcgatcctg cgcgacgggc agccccgcac caggggcgag
    18901 ctggcccggc tcaccggcct gtccaggtcc accgtctccc agcggctgga cgcgctgatc
    18961 ggctcccgct gggtcgtcga ggacgaaggc gcgatctcct ccgggggcag gcccgcctcg
    19021 atgttcacgt tcaacggcgg cgcccgggtc gtgctcgccg ccgacctggg cgccacccgc
    19081 gcccgcctgg ccgtcctcga cctcggcctg gacgtgctgg ccgagcaggt caccggcctc
    19141 cccgtcgacc tcggccccga gccggtgctc ggcgccgtcg ccacgtccct gcgccacctc
    19201 ctggccacgg ccgggcgcga ccccgcgcag gtgtgcgggg tggggatcgg cctgcccggc
    19261 ccggtcgagc accgcaccgg ccgcccggtg aacccgccga tcatgcccgg ctgggacggc
    19321 ttcccggtcc ctgagcgcct gcgcgaactc ctgggagagc ggccgaagga acgcccaggc
    19381 gatcaacccc gtgatcggcc gggggagtgg ccgggagcgc ccgtcctggt ggacaacgac
    19441 gtgaacgtga tggcgctggg cgagcactgg gccgcccgcc ccgccgtcga ccacctcatc
    19501 tacatcaaga tcggcaccgg catcggctgc ggcatcatct ccggcggccg gctgcaccgg
    19561 ggcgcgcgcg gcgccgccgg ggacgtcggc cacatccggg tgcccgcctc cggcgccccg
    19621 tgccggtgcg gcaacaccgg ctgcctggag gcggtcgccg gcggcgcctc gatggccgcc
    19681 gccctgcgcg aggccggcgc cgacgcgcgc ggcagcaagg acgtggtcgc cctcatgcgc
    19741 gccggcgacc ccctggccac ccgcctggtc cggcaggcgg gccgcgaggt gggcacggtg
    19801 atggccgcca tcgtgaactt cttcaacccg tccgtcatcg tgctcggcgg cgacgtcgcc
    19861 gaggccggcg agcaactgct ggccggcgtg cgggagacca tctacagcag gtcgctgccg
    19921 ctggccacgc agcacctcgg catcaggacc ggcgagctgg gcgaccgggc cggcgtcgtc
    19981 ggcgccgccg tcatggtcgt cgagcacgtc ctcgatccgg ccaccatcga cgaggccacc
    20041 ggagaacgtc cggcctgcat cgccgcgagg taggagacac cgccgccgcc gatcagccac
    20101 aaaggggata ttttgcgatc ttccgggcag ggggctcgcg atgtccaccc tcgacctcat
    20161 cctggccctc ggcggcgccg ccgcgttgct ggccgcgatc ctccccgagt tcctcgcccg
    20221 ccgggccctc tccctccccc tcgtctacct gctcgccggc atcctcctgt tcaccctgcc
    20281 cttagggctg cccgaccccg accccatcgc ccaccgcgtc gcgctggagc acatcaccga
    20341 gctgtgcgtc gtcatctccc tcatgggcgc cggcctggcg atcaaccgcc gcatcggccc
    20401 gcgcggctgg tccaccacgt ggcggctgct cgccctggcc atgccgctca ccgtggccgg
    20461 ggtggccgcc gcggccgtcg ccctgccggg ctggccgatc gccgccgcgc tgctgctcgg
    20521 cgccgtgctc gcccccaccg acccggtgct cgcctccgac gtgcacgtgg gcgagcccgt
    20581 ggacgcccag aacgccgacg acgaggtccg cttcgccctg acctcggagg cgggcctcaa
    20641 cgacgggctg gccttcccca tcgtgtacgc cgccatcgcc gtggcggccg gaaccgccgg
    20701 ttgggcgggg gagtgggcgc tgacggacgt cctctaccgc accgccgccg gcgccctgct
    20761 cggcctgctc atcggcggcc tgctcggccg cctgttcttc cgcgccaggt ccgacggcct
    20821 gcgcctggcc gagcgccgcg acggcttcgt cgccctggcc tgcacgttcc tcgcgtacgg
    20881 ggtgacggag ctggcccacg ggtacggctt cgtcgccgtg ttcgtcaccg cgtgcgccat
    20941 caggagcgcc gagcacggcc acggctacaa caacgtgctg cacggcttcg tcgagcagat
    21001 cgagcggctg ctcacggcct ggctgctgct cctgctcggc ggcttcgtcg cgaccggcgg
    21061 cctggcggcg ctcacctggc gcggcgccgc cgtcggcctc ctgctgctgc tcgtcatccg
    21121 cccgctggcc ggctggctgg tgcagtggcg cggccgggcg gggccgaggg aacggctggc
    21181 gatctcgttc ttcggcatcc gggggatcgg gtcgctgttc tacctggcgt acgcgctggg
    21241 gcaggccgac ttcggcgtgc cggcggagga gctgtgggcg gtcaccgggt tcaccgtcct
    21301 cgcctcggtc gtcctgcacg gcgtcaccgc caccccggtc atgaaccacg tggacgctct
    21361 gcgcaaggcg cacctgggcc gcggcggccg gtgagatgtt cttccggccg aaggcgggag
    21421 ttatcgctgc gggaaccgcc gggccacgta cgacgatcaa ggtgctgcgc ggcaccctga
    21481 aacggagtac gaccccatgg cacaccccac cctcggccgc cgcgcgctgc tcacggcggc
    21541 cgtcgccgcg cccgccgccg gcgccctcgc cggccccgcc gcctccccgg cgcacgcgtc
    21601 cgggaacggc ggccggttcg accgcgagag cccccgcttc acgatcggcg tcctgcccga
    21661 cacgcagtac ctcttcgacg aggaccgctc cgaccccgac cccgtgcgcc agacgttccg
    21721 cttcctgacc ggcggcgagc gcgagagcag gaacatcgcg ttcatgacgc acttggggga
    21781 cgtcaccgag cacggcaccc aagaggagct ggcgctcgcc tccgacacgt tccggcagct
    21841 cgacggccgc ctgccgtaca gcgtcctggc aggcaaccac gacgtgagcg gcgccgacga
    21901 ccagcgcggc gacagcgcgt acctgaaggc gttcggcccc tcccggtacg ccaggatgtc
    21961 caccttccgc ggcgcgtcgc ccgacggcta caacagccac cacgtcatcg aggcgggcgg
    22021 ccggcggtgg ctcgtgctcg cgctcgactg gcgcgtctcc gaccagggcc tgcgctgggc
    22081 gcagagcgtc atcgacgcga accggacgct gcccgccatc ctcaccaccc acgacctggc
    22141 ctgggcggac gacaccggcg ccgcggcgct gtcgcagcac gggcagcgcc tctgggacgc
    22201 cttcatcaag cgcaacgacc agatcttcct gacgctcaac ggccactact ggccgagcgg
    22261 ccgtaccgtg ctcaagaacg acgccggcca cgacgtgcac gtgcacatca ccaactacca
    22321 ggaccgctac tacggcggcg cgggcatggt ccggctctac gccttcgacc tcgtccgcaa
    22381 cgtgatcgac gtggagacga tctcgccctg gctgctggag cgcgacccgg acgagc
//
