LOCUS       NZ_CP020039            26808 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces sp. 3211 isolate 3 chromosome, complete genome.
ACCESSION   NZ_CP020039
VERSION     NZ_CP020039.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. 3211
  ORGANISM  Streptomyces sp. 3211
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8232231)
  AUTHORS   Heinsch,S.C., Hsu,S., Hansen,L., Kinkel,L. and Smanski,M.J.
  TITLE     Complete genomes of three Streptomyces isolated from disease
            suppressive soils
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8232231)
  AUTHORS   Heinsch,S.C., Hsu,S., Hansen,L., Kinkel,L. and Smanski,M.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-MAR-2017) Biotechnology Institute, University of
            Minnesota, 1479 Gortner Ave, Saint Paul, MN 55108, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 20-JAN-2017
            Assembly Method                   :: PacBio v. Jan-2016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: PacBio; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 03:18:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,254
            CDSs (total)                      :: 8,154
            Genes (coding)                    :: 7,815
            CDSs (with protein)               :: 7,815
            Genes (RNA)                       :: 100
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 340
            CDSs (without protein)            :: 339
            Pseudo Genes (ambiguous residues) :: 0 of 340
            Pseudo Genes (frameshifted)       :: 206 of 340
            Pseudo Genes (incomplete)         :: 257 of 340
            Pseudo Genes (internal stop)      :: 68 of 340
            Pseudo Genes (multiple problems)  :: 153 of 340
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:04:45
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7766397
            Orig. end                         :: 7793205
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP020039.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Michael Smanski.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26808
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="34"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..26808
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26808
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:21808]"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..21808
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     gene            725..1702
                     /locus_tag="B4U39_RS35315"
     CDS             725..1702
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0003960 - NADPH:quinone reductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_function="GO:0070402 - NADPH binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (14-315). E-value: 2.3e-49.
                     Score: 160.1. Matches aSDomain:
                     nrpspksdomains_B4U39_RS35315_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018546602.1"
                     /locus_tag="B4U39_RS35315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NADPH:quinone oxidoreductase family protein"
                     /protein_id="WP_079407261.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 4.3e-29, bitscore:
                     99.9, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQAWRVHTPGEPREALRLEEIPEPVPGEGEVRLQVLAANLNFPDA
                     LLVRGQYQIRPPLPFTPGVEICGLTDDGRRVIANPSLPHGGFAEYVVASERSLLPAPES
                     LNDAEAAALHIGYQTGWFGLHRRARLQPGETLLVHAAAGGVGSAAVQLGKAAGATVIGV
                     VGGKAKARTAEELGCDLVIDRTTEDVVARVKEFTGGRGADVVYDPVGGASYTASAKCVA
                     FEGRIVVVGFASGDIPAPALNHALVKNYAILGLHWGLYAAKDPGAIAACHAELTRLATE
                     GTIKPLISELIALPAVADAVQRLADGATTGRVVLAMPRQPGVSR"
     aSDomain        767..1669
                     /ASF="ER domain putatively catalyzing 2S-configuration
                     product formation"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B4U39_RS35315_PKS_ER.1"
                     /evalue="2.30E-49"
                     /label="B4U39_RS35315_PKS_ER.1"
                     /locus_tag="B4U39_RS35315"
                     /protein_end="315"
                     /protein_start="14"
                     /score="160.1"
                     /tool="antismash"
                     /translation="ALRLEEIPEPVPGEGEVRLQVLAANLNFPDALLVRGQYQIRPPLP
                     FTPGVEICGLTDDGRRVIANPSLPHGGFAEYVVASERSLLPAPESLNDAEAAALHIGYQ
                     TGWFGLHRRARLQPGETLLVHAAAGGVGSAAVQLGKAAGATVIGVVGGKAKARTAEELG
                     CDLVIDRTTEDVVARVKEFTGGRGADVVYDPVGGASYTASAKCVAFEGRIVVVGFASGD
                     IPAPALNHALVKNYAILGLHWGLYAAKDPGAIAACHAELTRLATEGTIKPLISELIALP
                     AVADAVQRLADGATTGRVVL"
     CDS_motif       1121..1180
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B4U39_RS35315_0001"
                     /evalue="7.10E-08"
                     /label="PKSI-ER_m5"
                     /locus_tag="B4U39_RS35315"
                     /protein_end="152"
                     /protein_start="132"
                     /score="24.8"
                     /tool="antismash"
                     /translation="GETLLVHAAAGGVGSAAVQL"
     gene            1699..2892
                     /locus_tag="B4U39_RS35320"
     CDS             1699..2892
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267930.1"
                     /locus_tag="B4U39_RS35320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_079407262.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 7.8e-11, bitscore:
                     41.4, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.4e-20, bitscore:
                     72.0, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 2.8e-19, bitscore:
                     68.6, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAITAEHLRTRVRGLLAAHPPADTDRADFLRARFDAGLAWVHYP
                     EGLGGLGAPRSLQAVVDAELEAAGAPDNDPRRIGIGLGMAAPTILAYGTVEQKQRFLRP
                     LWLGEEVWCQLFSEPGAGSDLAALGTRAVRETDSGDWIVDGQKVWTSSAHTARWAILIA
                     RTDPALPKHQGITYFLCDMHAPGVEVRPLRQITGEAEFNEVFLTGVRIPDTHRLGAVGE
                     GWAVARTTLMNERVSIGGMRIPREGGMIAPVAAAWRDRPELRSHALHQRLLELWVEAEV
                     ARLTGERLRQQLVAGQPGPEGSGMKLTFARLNQEISALEVELLSEEGLLYDDWTMRRPD
                     GVDFTGREAGYRYLRAKGNSIEGGTSEILLNIVAERVLGLPPEPRDDKDLAWKDLSR"
     gene            2889..4076
                     /locus_tag="B4U39_RS35325"
     CDS             2889..4076
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267931.1"
                     /locus_tag="B4U39_RS35325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_079407263.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 5.1e-12, bitscore:
                     45.2, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 2.9e-27, bitscore:
                     94.5, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTQPTPTAPQAAPVPTAATAPTTPVAPAAPADLLYSGTEEELRA
                     AVRALLTDRCDAKSVLARVETDRPHDPELWRTLAVGIGAAGLLVPEKLGGQGASHREAA
                     VVLEELGRSVAPVPYLTSAVLATEILLGCDSAEATALLRELASGRTVCVPAVPLTLAPG
                     APLPTPVRDLGDGSLTGTVTSVADAVAADVLLVLADTGLYAVPAASARLTPQVPLDLTR
                     PLATVTLEAAAGTRLADPGTARAAVAGALLSGAGLLASEQLGIAEWCLTETVGHVRGRH
                     QFNRPIGSFQALKHRLARLWLDVASARAAARAAADALATAAPDAPLTVAVAQAYCSGVA
                     VRAAEECVQLHGGIGMTWEHPAHLYLKRAKADSLALGTAGHHRGLVADFAELPAP"
     gene            4238..4384
                     /locus_tag="B4U39_RS42890"
     CDS             4238..4384
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B4U39_RS42890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_159395717.1"
                     /transl_table=11
                     /translation="MLLVLIASVAASTMLCLRRRSLPHRTLALRMGAIFGDLHLPRLRR
                     TAG"
     gene            4401..4940
                     /locus_tag="B4U39_RS35330"
     CDS             4401..4940
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007453627.1"
                     /locus_tag="B4U39_RS35330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_079407265.1"
                     /transl_table=11
                     /translation="MTATITALSATGLRAHRDELASLLLAVVDGGSSLGFLAGLEHREA
                     AAWWDSLLPAVEDGSLALWISRTGDDGRIDGTVSWYRETKANGRHRAELRKLMVHPAAR
                     GRGTARALLAEAESAAARAGVVLLILDTETGSGAERIYRSAGWTEAGTIPDYASDPAGR
                     LHPTTLFYKQLRSAHG"
     misc_feature    complement(4994..5007)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.71"
                     /tool="antismash"
     gene            5001..5369
                     /locus_tag="B4U39_RS35335"
     CDS             5001..5369
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018487584.1"
                     /locus_tag="B4U39_RS35335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_079407266.1"
                     /sec_met_domain="melC (E-value: 5.4e-41, bitscore: 138.8,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAASPAAPLTRRALLRTAFTAAVLAGAGAALAPVLRARRPRQTL
                     TPAPLAEEETYRGRHIAVDVAGVRIDGRPLHVMRRADGSYLSGINHFQSYPTPLELARA
                     AVDELGTAQLALAAPHHG"
     gene            5399..6262
                     /locus_tag="B4U39_RS35340"
     CDS             5399..6262
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267933.1"
                     /locus_tag="B4U39_RS35340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase family protein"
                     /protein_id="WP_053702693.1"
                     /transl_table=11
                     /translation="MHTRQNQKNLTSAQKKRFTAAVLELKRSGAYDALVRTHDKYFVPD
                     RDRKLRVGHMSPSFFPWHRRYLLEFERQLQEIDPGVSVPYWDWTTDSSPASSLWADDFL
                     GGTGRTGDRKVMTGPFAYDKGNWTVTVGITESAFLTRNLGRPQNPITLPTAAELQWAID
                     DPTYDVAPWDSTATAGGFRNKLEGWAAPKSERWRNHNKVHQWIGGHMTGGTAPNDPAFW
                     LHHAFVDLIWDRWQQKHPGSGYLPAAPLAVGDLQRGRVIARDEPMPPWNITPREMSDHR
                     SLYRYE"
     gene            complement(6344..6631)
                     /locus_tag="B4U39_RS35345"
     CDS             complement(6344..6631)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018512958.1"
                     /locus_tag="B4U39_RS35345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="chaplin"
                     /protein_id="WP_030384797.1"
                     /transl_table=11
                     /translation="MSRIAKAFAITAVTGSAVVAGAGLAVADAGAHGAAVGSPGVLSGN
                     LLQVPVHVPVNVCGNTVNVIALLNPAFGNTCVNASGGGSDHHTEGGDYGH"
     misc_feature    complement(6679..6689)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(6729..7052)
                     /locus_tag="B4U39_RS35350"
     CDS             complement(6729..7052)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B4U39_RS35350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_079407268.1"
                     /transl_table=11
                     /translation="MRFLRIHHAVPVAVLLAGATLLSGPAVAVGPDFQYVGQDDRVHGL
                     TAPKGCVEAEGGGARAVTNGTRGSATLFEGPGCSGRVLRVLRPGEVGQVRPYFASVRFS
                     VTG"
     misc_feature    complement(7048..7061)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.21"
                     /tool="antismash"
     gene            7152..8618
                     /locus_tag="B4U39_RS35355"
     CDS             7152..8618
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010042510.1"
                     /locus_tag="B4U39_RS35355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="carboxylesterase family protein"
                     /protein_id="WP_079407269.1"
                     /transl_table=11
                     /translation="MSAEPYGHRPRVRTAGGVVEGRTGPGGTAVFLGIPYAAPPVGALR
                     FAAPAPPAAWDGVRDAAAYGPTAPKVPYPDTFAALLPDPVIPGDDCLNLNVWTPDPAPG
                     ARLPVMVWIHGGAHTRGSSAVPVYDGSAFARDGVVLVSFNFRLGVLGYGLFPDAPVNRG
                     LLDQIAALTWVRDNIGAFGGDPDRVTVFGESAGAISIGSLLAAPRAAGLFSRAVLQSGA
                     PEVLPRVRVRAMVRRMASLLKVDATAAAFTATPLPDLLAAQGAVLRRSGPLLGGPAFGL
                     VTDPDTVPTDPLDALCDRAASTGVPLLLGWTSDEYRLWLAPTGGMRLLDRLGPLSVALA
                     RAHAGKDRAAVRALRTALPAATPAELAGQLLTDRLLRDPLRRLAGARRAAPSFLYEFGW
                     PSGLPGLGACHALELGFVFDTLAAPEAAWLAGAQPPQALADEMHAAWVRFAVEGDPGWA
                     AWNGDGPPKMFGGPSLDPEQAPVITRPVLP"
     gene            complement(8596..9879)
                     /locus_tag="B4U39_RS35360"
     CDS             complement(8596..9879)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1104: putative esterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266297.1"
                     /locus_tag="B4U39_RS35360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase-fold protein"
                     /protein_id="WP_078938305.1"
                     /transl_table=11
                     /translation="MSYAPDGQQYQPYRPEGQIPQPPHGDPYAQPYGQQPHRQPQGQQD
                     RYGQQAQYAPQDPYEQTARYGPQDLYPEEPPRRRRGRRWLIAGAAVLALAGTAALVLNH
                     YEIPPFTDKGSAVSFGQTPAGGGKKDDAPPPANSKMLMPTGPAAEFKNSMTLPDGTHVA
                     VTTLDGKKSGFKGKVWVWAPKEYNDPKFAKSGFPVMIALPGGAGYPSNYWMGTDLGLQT
                     SISKWYTEGKSKPFILAMPVLNPAPDDKGIYWDGSDIPGQPKMGTWLTEDVPDLVKANF
                     RTVKSRDGWAFMGSSTGGFAGLKAVLKHPDKFKAVIASGPDIVPDSSLWKGHEKEKAEN
                     NPELLAKQLIDTKGPDVYLAFQVGDSENNKKTLPDVQKFIATYGNKGPVHTELRVIKGG
                     QHNAKTYVPNMGEGPIQYISKVMEGPVE"
     gene            10146..11174
                     /locus_tag="B4U39_RS35365"
     CDS             10146..11174
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014672332.1"
                     /locus_tag="B4U39_RS35365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_079407270.1"
                     /transl_table=11
                     /translation="MTLQRRILILATAVALLAAVCVLAVVRASSRADEKDHARAGGPQI
                     APGAVSLAPGDGGRRIVFRNMAWGPHRDELATVAAGAPGGTRTASGVSCLRFHAAGGTG
                     ICLQADRNGVQEGYRALVLDARLKEISAHPLGGVPTRARVSPGGHLAAWTVFVGGDSYA
                     GTDFSTRTSVLDLRTGRLEASLEEFTILKDGKPYRAADVNFWGVTFTADERTFYATLAT
                     GGRTHLVRGDLVERSVTTLRENVECPSLSPDGTRLVFKKRVPGLPAEVPWRLYALDLAS
                     GAETPLGEERSVDDQVVWIDERTVVYALPGDFGADLYALPADGSGAPARLMDSALAPAF
                     LG"
     gene            complement(11236..11922)
                     /locus_tag="B4U39_RS35370"
     CDS             complement(11236..11922)
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267942.1"
                     /locus_tag="B4U39_RS35370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family protein"
                     /protein_id="WP_030384802.1"
                     /transl_table=11
                     /translation="MPVPVHLAGRTVRLEPLAPHHTEALAVAGAEDRTTYAFTPVPHGV
                     QASHEYIDRALADQAAGRSLPFAVVRATDGRVVGSTRFLELDYWQGPLVWPAVPGVPFG
                     DPATAIPDAAEIGNTWLSPGAQGTGINTEAKLLMLRHAFETWGVRRISLRADARNGRSR
                     AAMERLGFTCEGVRRAHSRGLDGAVRSTAFYSILDEEWPAVRSIIELRLSAGAQRKRRR
                     KTLVPA"
     gene            12466..13161
                     /locus_tag="B4U39_RS35375"
     CDS             12466..13161
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267945.1"
                     /locus_tag="B4U39_RS35375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="WP_079407271.1"
                     /transl_table=11
                     /translation="MDDVLRRLAAVGPFFTVPYGTEPPGPGFRPLTALYGERLAPYVAE
                     VGRRIGSGPGRVAASTAQFGIVSRLWSLGLGSAALGGRVPDLSADRVWWRMPDAGSLQL
                     WLPEPGPGLPAEELGRNVLANLAALDAALRVRYGVSAQVLRGNAASGLVGALRVLIDRV
                     PGGAAVELAGALLADGGALAGTGTFIHEEGLGVAFERRSCCLYYQVPGGGLCGDCVLRA
                     RRRPDRRRA"
     gene            13268..14665
                     /locus_tag="B4U39_RS35380"
     CDS             13268..14665
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606826.1"
                     /locus_tag="B4U39_RS35380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_079407272.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3e-07, bitscore:
                     30.1, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTARTPHRPAALTRRAALAGLAAGAGALAAGGTARTATAAPGPSA
                     KAADPTPGAMQLFDDPGFNFAGLLALGAAGMRASEVGEVLTAVNAINAAGPSEHTFSDT
                     FRAWGDRLAAPPAAGRHGHEAPSQTRRFRSLRAAQYYAQALFYVLGTDHPGDEEAVYLA
                     GRKAWDTFNRLCSPAAVRAKVPYGRTHLPVWFFRPDGPARPRPTVILTNGSDGQNLDMW
                     TYGVSAALDRGWNALVYDGPGQGQLLFVEEIPFTTRWEKVVAPLVDWLEARQDVDSGRI
                     ALTGLSMGGNLVARAAAFEHRLAAVACQPGCVSPWLGFDAELRAIITPDKEETNRVWNE
                     EVVPELTPQLAFTVKKRFEIFDRQALRQAREGVVLTDVWTPAQVAMGLDITEVVGRIKA
                     PTLVLDYDFELFYPGQPQQMYDLLRTRREYVKMTEATGAQLHCSPMAPQQHCDVVFDWL
                     ADVLRRR"
     gene            complement(14683..16455)
                     /locus_tag="B4U39_RS35385"
     CDS             complement(14683..16455)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123169.1"
                     /locus_tag="B4U39_RS35385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S8 family serine peptidase"
                     /protein_id="WP_079407274.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 2.1e-42, bitscore:
                     144.2, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLAATLGAALAFGAPAALAGTAPVAPNGSSAPAPAAAPKAAAPTS
                     QSATWVAGTRAYLVITAPGDTTAVRSAVTANGGTVFNHYDAIGVIIAHSASGTFATTMR
                     GVSGVQQVGATRTSDVPADAYNPALPANPAQSTTPSGEPVRADMTQIKADQAWAVTTGS
                     ASVKVGILDTGVDDQHQDLAPNFNAADSASCAYGKPDTRSGAWRDVGTHGTHVAGTVAA
                     AKNGKGVIGVAPGVKISSVRIAEPTSSLFFAENTVCGFMWAGDHGFKVTNNSYYTDPWQ
                     FNCPDNADQAAIIEGVKRAQEYAEGKGSLQVAAAGNSNIDLANKTTDTESPNDSTPVTR
                     TITNACLDIPTELPGVVTVSAMGTTAKASYSNYGLNVVDVTAPGGDATGIYSTLPGGKY
                     GSMSGTSMASPHVAGVAALLASTNPGITPAQLRDKLATQANDVACPSDGRCKGTTAKNG
                     FFGEGQVDALKAVGSTPPPGKYFENAGDFAIGDNATVESPITVSGVTGNAPATLKVGVN
                     VVHTYIGDLKVDLIAPDGTVYTVHNRAGGSTDNINQVYTVNASSEVANGTWKLRVNDNA
                     GGDTGRIDSWNLTF"
     gene            complement(16721..18145)
                     /locus_tag="B4U39_RS35390"
     CDS             complement(16721..18145)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015293 - symporter activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1212:
                     sodium:dicarboxylate symporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267948.1"
                     /locus_tag="B4U39_RS35390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cation:dicarboxylase symporter family
                     transporter"
                     /protein_id="WP_079407275.1"
                     /transl_table=11
                     /translation="MAARRDRTHYLYIAVIGAVLLGIAVGFAAPGVAVELKPLGTGFVN
                     LIKMMISPVIFCTIVLGIGSVRKAAKVGAVGGLALGYFMVMSTVALAIGLLVGNLLEPG
                     SGLHLTEAARSAGEAQAKAGGAESTPEFLLGIIPTTMVSAFTGGEVLQTLLVALLCGFA
                     LQAMGAAGEPVLRGIGHIQKLVFRVLAMIMWAAPVGAFGAIAAVVGATGVDALKSLAVI
                     MIGFYTTCLLFVFVVLGTLLRVCTGVSVFALLRYLGREFLLILSTSSSESALPRLIAKM
                     EHLGVSRPVTGITVPTGYSFNLDGTAIYLTMSSLFVAEAMGKPLALGEQISLLLFMIIA
                     SKGAAGVTGAGLATLAGGLQSHRPELVDGVGLIVGIDRFMSEARALTNFAGNAVATVLI
                     GTWTKEFDHARASEVLAGRLPFDESTLVDDGHGAQQKGEPAQPTGPTGATGSDASDGTP
                     NSVPQPSINPKDGVPV"
     misc_feature    complement(18193..18208)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     gene            18251..19921
                     /locus_tag="B4U39_RS35395"
     CDS             18251..19921
                     /EC_number="2.7.13.3"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009714920.1"
                     /locus_tag="B4U39_RS35395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sensor histidine kinase"
                     /protein_id="WP_237296945.1"
                     /transl_table=11
                     /translation="MFRFPRPPRSLAGQLFAMQVLLVAVVVAGCAVFAYATARSQAEEA
                     ARRQAGAVALAVADSPSVREAVRAAVRGTDPSVALQPYAEQVRVDSGVNFVTIMSPEGR
                     RWTHPDPRRIGEPFMGNTARALRGETFSETYTGTLGPSIRVVTPLRDEGRIVGLVSAGI
                     TVRTISDRLATQLSALVWVAGGALALGGVGTYVVNARLRRHTHGMNAAELSRMYDYHQA
                     ALHGVREGLLMLDGQRRITLINDAGRELLALPGDVTGTGVADLGLPAPLTGALLADRPR
                     VDEVHLTADRVLVVNSSPVAGGGRRGTVVTLRDHTELQALTGELDHERGFTQALRSQAH
                     EAANRLHTVVSLIELGRADEAVDFATAELELAQALTDEVVTAVGEPVLVALLLGKAAQA
                     HERGVELVVTADSRSLAEGGGLPPARDLVTVLGNLIDNAVDALTAVPGARIAVTLRPEP
                     QGLLLRVADNGPGLPEGVDVFRRGWSGKGEGRGLGLALVRQVAERYGGAVVAAPGPGGG
                     AEFTVRLPMAPAAGTDPRDPGDVADPADLADPADAAGPR"
     gene            19918..20622
                     /locus_tag="B4U39_RS35400"
     CDS             19918..20622
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004925330.1"
                     /locus_tag="B4U39_RS35400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator"
                     /protein_id="WP_030384808.1"
                     /transl_table=11
                     /translation="MSAGEVRVLVVEDDPVAADAHALYVGRVPGFTAVGAVHSLAEATR
                     FLERTRVDLLLLDLGLPDGHGLRFARGLRAAGHPVDVIVVTSARDLAVVRESVSLGVVQ
                     YVLKPFAFPTLRERLLRYAEFRQAAGEAAGQDDVDRAMAALRAPRPAELPKGLSAPTLD
                     RVAALLRAAPEGLTSAGTAEAAGISRITARRYLEHLVDTGRADRTPRYGQVGRPELHYR
                     WLAAATGSVSKV"
     gene            complement(20577..21425)
                     /locus_tag="B4U39_RS35405"
     CDS             complement(20577..21425)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267950.1"
                     /locus_tag="B4U39_RS35405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase family protein"
                     /protein_id="WP_079407276.1"
                     /transl_table=11
                     /translation="MTVRKNQATLTPAEKRAFTSALQELKRNGSYDRFVTTHNGFIMSD
                     TDSGDRVGHRSPSFLPWHRRFLLEFEEALQKVDASLALPYWDWTADRTSRSSLWAPDFL
                     GGTGRARDGQVMDGPFAYATGKWNINVRVDGRAYLRRDLGTSVAQLPTRAEVDAVLAMP
                     VYDMAPWNSSSNGFRNNLEGWRGANLHNRVHVWVGGQMSTGVSPNDPVFWMHHAFIDKL
                     WAEWQAKHPESTYLPGAGTQNVVDLNDTMRPWNNVTPADMLDHRKFYTFDTEPVAAASQ
                     R"
     gene            complement(21422..21808)
                     /locus_tag="B4U39_RS35410"
     CDS             complement(21422..21808)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514978.1"
                     /locus_tag="B4U39_RS35410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase cofactor"
                     /protein_id="WP_030384810.1"
                     /sec_met_domain="melC (E-value: 1.7e-44, bitscore: 150.1,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKITRRQALGTTAGALTALGLTAAAAGATSAAATPAEPTTPGTV
                     DEVYQGRRIQITPGGGGHHGGHHSPGQPTVRIDGRELHIMRNADGTWISVINHYETFAE
                     PKLLARAAVRDLQGAALVPFGGAA"
     misc_feature    22050..22060
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 17.67"
                     /tool="antismash"
     gene            complement(22060..23280)
                     /locus_tag="B4U39_RS35415"
     CDS             complement(22060..23280)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007269044.1"
                     /locus_tag="B4U39_RS35415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="erythromycin esterase family protein"
                     /protein_id="WP_079407278.1"
                     /transl_table=11
                     /translation="MPIDIKDTARALDAAALRGPFAARPRLLALGEPTHGEDTLLEVRN
                     ELFRQLVAQGGYRTIAIESDCLAALLVDAYVTSGAGSLDEVMERGFSHGFGASAANREL
                     VRWMRAFNEGRPAPEQLRFAGIDGPLEMAGAASPRRALTALHDHLARHLDAGLLPCTAP
                     ALDRLLGADDRWTEPAAMMDPARSTGGSAEARELRLLADDLVALLEEHTPHLLAATSRE
                     DLDRARLYGRTATDLLRYHRWMADTSPARMTRLVGLRGRMMADNLLALAARGPVLVHAH
                     NAHLQREKSSMRMGGRLLEWWSAGALVSARLGTEYAFVATALGTIRHRSVDAPPPDTVE
                     GLLYALPDDPCVVDARQLATVLGGAPPAPRVSPWFGYAPLDPAHLASMDGVVFIKDLPD
                     VPAPSTP"
     misc_feature    complement(23310..23321)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.65"
                     /tool="antismash"
     gene            23339..24079
                     /locus_tag="B4U39_RS35420"
     CDS             23339..24079
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005317230.1"
                     /locus_tag="B4U39_RS35420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TioE family transcriptional regulator"
                     /protein_id="WP_079408201.1"
                     /transl_table=11
                     /translation="MSQNLQSGRRLRPVDLARGHGLSTQAIRNYEEAGILPAADRTPHG
                     YRTYTLLHARALAAFLALVQGHGHRTAASIMRAVNEGAADEAFRLIDGTHAQLLADRRT
                     LEAVEKALRALEPADGAFELDAVSAAPSGGTFIGPLARELGLRPATLRAWERAGLIRPR
                     RDPLTKYRVYDAADVRDARLAHQLRRGGHLLEEIAPLLAQVRAAGGLAPLESALTAWRA
                     RLSARGRALLAGAAELDTYLRARD"
     gene            24337..25359
                     /locus_tag="B4U39_RS35425"
     CDS             24337..25359
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006603843.1"
                     /locus_tag="B4U39_RS35425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_079407280.1"
                     /transl_table=11
                     /translation="MTTRRLSAVFGVLLATALAHTGLAPVAAAAPSGSGSGHGARPAAP
                     AQYLYSSIGDFDSEVKPLADRPDIAGVQVVVPWKALEPQKDQYDFSAVEEALGYLQARH
                     KKLFVQVQDRFFSAPTRLPNYLLTDPVYAGGAAATTNESGLGPGEPGAVAAQWNPEVRG
                     RFQRLLQALADRFDGRLAGVNLPETATQVDLGKDRSGYTDESYFRAELDNMAFGAKVFK
                     RTQFIQYVNFWPGEWNNDHGYMEKTFRFAEAHGVGLGGPDVLPNRQAQMENSYPFFERY
                     RGRLPMVAMAVQEPDFEYINPATGKPYTKEEFVDFGGRRLGADVMFWATAAPWLHRPGS
                     "
     gene            complement(25403..26473)
                     /locus_tag="B4U39_RS35430"
     CDS             complement(25403..26473)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B4U39_RS35430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_079407281.1"
                     /transl_table=11
                     /translation="MSPSPASGRQLDELAAFALAHAGDAPGKGEGAGADAVFLFADDIE
                     DRYLYTFADLAGAREHLADPTHGYLRCAVAWRPGPDVLSVRAQEIGSSTSFVLTRRCAP
                     DGPAEDVVRAEGAPALLPPPGAAAGTNAEPGYCAKPADLADLTALADLEDGLERAVDSG
                     EGLVEAEDRLRRWVGRADEGDWAATERWLRSRFPTGDEPDASDGALPDGAPAGARPPGR
                     YTIDFHGSDAPTGPVAALATWDRIARQAREILGPTAAPVDGTAVGHPGSGVRLALDRAS
                     GRYELSAPLPEDGAAPATQVLEQLYRLALTVQLETGRRAADPQIGRYVDQLGGATWARR
                     IGLVARAVRSFRPGRP"
     misc_feature    26512..26529
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.58"
                     /tool="antismash"
     misc_feature    26607..26616
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.41"
                     /tool="antismash"
ORIGIN
        1 ggccgtcctt ccagacggca ccgggcccgc tgtccgagcg ggccaccacg tacccggcgt
       61 cattgacgtc ggcctcgtcg tcgtaggcgt agctgtccgg cagcagcgtg atcgccgcag
      121 cgcccgcctg gtaggtgaac agggagtgga cgccggagcc gtggaggacg cccaccatca
      181 ggccgtgcgc gttgacggcg accacccggc ccgacgcgtt cgggtcggtc agcggcaccc
      241 ggtgcaccgt ggtgccggtc cagtaggcgg gcttgtagcc ggagacgccg acggcgaggt
      301 tgcccgcacc gaggtcgaag acgccctggc tgcgctgcat gtcgcggacg tacgactcgt
      361 ccccgagcgt gccgagcacc tggatcttcg gcgtgcactt cgcctcgacg gccgcgacgg
      421 cctcgaccgc ttcggccgcc acggccgggc cggccgcggt gatcaggccg gccagaacga
      481 ttgcggctgc ggccgcggac atgcttcttc tcatggagtg gtcccccctg gacaggtgct
      541 gttccccgtt gagtcatgac acgtgcacgc cacatattgc ctgatcttga aacggatgtg
      601 gcctgaatgg cgcgtgttga tgcgctgcgg ggccccggca cccggcggat ggttcccagg
      661 gaggcaagcg actgcttagt atgcccgcgg agcgtggttc cccgacggcg gctggaggcc
      721 ccggatgcag gcatggcgag tacatacccc cggcgaaccc cgagaggccc tgcgcctcga
      781 agagattccc gaaccggtcc cgggtgaggg cgaggtgcgg ctgcaggtgc tcgcggcgaa
      841 cctcaacttc cccgacgcgc tgctcgtccg cggccagtac cagatccgcc caccgctgcc
      901 cttcaccccc ggcgtcgaga tctgcggcct caccgacgac ggccgccgcg tcatcgccaa
      961 cccgagcctg ccccacggcg gcttcgccga gtacgtggtc gcgtccgagc gatccctgct
     1021 cccggccccc gagagcctga acgacgccga ggccgcggcc ctgcacatcg gctaccagac
     1081 cggctggttc ggcctgcacc gccgggcacg cctccagccg ggcgagaccc tcctcgtgca
     1141 cgccgccgcc ggtggggtcg gcagcgccgc cgtccagctc ggcaaggccg ccggggccac
     1201 cgtcatcggg gtggtcgggg gcaaggccaa ggcgcgcacc gccgaggaac tcggatgcga
     1261 cctggtgatc gaccgtacga ccgaggacgt cgtcgcccgg gtcaaggagt tcacgggcgg
     1321 gcgcggggcc gacgtggtct acgaccccgt cggcggcgcg tcgtacaccg cctccgccaa
     1381 gtgcgtggcc ttcgagggcc ggatcgtcgt cgtcggcttc gcgagcggcg acatcccggc
     1441 ccccgccctc aaccacgccc tcgtcaagaa ctacgcgatc ctcggcctcc actggggcct
     1501 ctacgcggcc aaggacccgg gggcgatcgc cgcctgccac gccgaactga cccgcctcgc
     1561 caccgaaggc accatcaagc ccctgatcag cgaactcatc gcactccccg ccgtcgccga
     1621 cgccgtgcag cgcctcgccg acggcgccac caccggccgc gtcgtcctgg ccatgccccg
     1681 gcagccgggt gtgtcccgat gaccgcgatc accgccgagc acctacgcac acgggtccgg
     1741 ggcctgctcg ccgcccaccc gcccgccgac accgaccgcg ccgacttcct gcgcgcccgc
     1801 ttcgacgccg gactcgcctg ggtccactac cccgagggcc tcggcggcct cggcgcaccc
     1861 cgctccctcc aggccgtcgt cgacgccgaa ctggaagccg cgggcgcgcc cgacaacgac
     1921 ccgcgccgca tcggcatcgg cctcggcatg gccgcgccca cgatcctcgc ctacggcacc
     1981 gtggagcaga agcagcgctt cctgcgcccc ctgtggctcg gcgaggaggt ctggtgccag
     2041 ctcttcagcg agcccggcgc cggttccgac ctcgccgcgc tcggcacccg cgcggtccgc
     2101 gagacggact ccggcgactg gatcgtggac ggccagaagg tatggacctc cagcgcccac
     2161 accgcccgct gggccatcct gatcgcacgc accgaccccg cgcttcccaa gcaccagggc
     2221 atcacctact tcctctgcga catgcacgcc cccggcgtcg aggtccggcc gctgcgccag
     2281 atcaccggcg aggccgagtt caacgaggtc ttcctcaccg gcgtccgcat ccccgacacc
     2341 caccggctgg gtgccgtcgg cgagggctgg gccgtggccc gcaccaccct gatgaacgag
     2401 cgggtctcca tcggcggcat gcgcatcccg cgcgagggcg gcatgatcgc ccccgtcgcc
     2461 gcagcctggc gcgaccgccc cgagctgcgc tcccacgccc tccaccagcg gctgctggaa
     2521 ctgtgggtcg aggccgaggt cgcccgactc accggcgaac ggctgcgcca gcagctggtc
     2581 gccggacagc ccggccccga gggatcgggc atgaagctca ccttcgcccg gctcaaccag
     2641 gagatcagcg ctctggaggt cgaactcctc tccgaggaag gcctcctgta cgacgactgg
     2701 accatgcgcc ggcccgacgg cgtcgacttc accggccgcg aggccggcta ccgctacctg
     2761 cgcgccaagg gcaacagcat cgagggcggc accagcgaaa tcctcctcaa catcgtcgcc
     2821 gaacgcgtcc tcggcctgcc ccccgagccc cgcgacgaca aggacctcgc ctggaaggac
     2881 ctgtcccgat gacaacgcag ccgacaccga cggcaccgca ggcggcgccc gtgccgacgg
     2941 cagcaaccgc tccgacgacg ccggtggccc ccgcggcgcc ggccgacctg ctctactccg
     3001 ggaccgagga agagctccgc gccgccgtgc gcgcgctcct gaccgaccgc tgcgacgcga
     3061 agagcgtcct cgcccgggtc gagaccgacc ggccgcacga ccccgaactc tggcgcaccc
     3121 tcgccgtcgg gatcggcgcc gccggcctcc tcgtacccga gaagctcggc gggcagggcg
     3181 cgagccaccg ggaggcggcc gtggtcctgg aggagctggg ccgctccgtg gcgcccgtcc
     3241 cgtacctgac gagcgccgtg ctcgccacgg agatcctgct cggctgcgac agcgccgaag
     3301 ccaccgcgct gctgcgggaa ctggcctccg gccgcacggt gtgcgtaccg gccgtgcccc
     3361 tgaccctcgc cccgggcgcc cccctgccga cccccgtccg ggacctcggc gacgggagcc
     3421 tgaccggcac ggtcacctcc gtggcggacg ccgtggccgc cgacgtcctg ctggtcctgg
     3481 ccgacaccgg gctctacgcc gtcccggccg cctcggcgcg gctgaccccg caggtcccgc
     3541 tcgacctgac ccgccccctc gccaccgtca cgctggaggc ggccgcgggc acccgcctcg
     3601 ccgatccggg aacggcccgg gccgcggtcg ccggagccct gctctccggg gccggactgc
     3661 tcgcttccga gcagctcggg atcgccgagt ggtgcctgac ggagaccgtc ggccacgtcc
     3721 gcggccgcca ccagttcaac cgccccatcg gttccttcca ggccctcaag caccgcctcg
     3781 cccggctctg gctcgacgtg gcctcggcgc gcgcggcggc cagggccgcg gccgacgccc
     3841 tggccaccgc ggcccccgac gccccgctga ccgtcgccgt ggcccaggcc tactgctcgg
     3901 gcgtggccgt ccgcgcagcc gaggagtgcg tacaactgca cggcggcatc ggcatgacct
     3961 gggaacaccc ggcccacctg tacctcaagc gggccaaggc cgactccctg gccctcggca
     4021 cggcgggcca ccaccgcggc ctggtcgcgg acttcgcgga actccccgca ccgtagcccc
     4081 ggctcgcccc cgcccccgcc ccgcgcccgc cccgggcggg gcggggagat ggccgaacgg
     4141 ccgatacggg cgcggccccc ggtgcggcac cctcgacggg tccccgtacg ccccgcgaag
     4201 gaggcgtacg ccccgcccgt cccctgaagg aggcgccgtg ctgctcgtcc tcatcgcctc
     4261 cgtcgcggcc tcgaccatgc tctgcctgcg ccgccgcagc ctcccgcacc gcaccctcgc
     4321 gctccggatg ggcgcgatct tcggcgacct gcacctcccc cgcctgcggc ggaccgccgg
     4381 ctgatcccta tcctcgcccc atgacggcca ccatcaccgc gctctcggcg accggactgc
     4441 gcgcccaccg cgacgaactc gcctccctcc tgctggccgt cgtcgacggc ggctcgtccc
     4501 tcggcttcct cgccggcctc gagcaccggg aggccgccgc ctggtgggac tcgctgctgc
     4561 ccgcggtcga ggacggctcc ctggccctgt ggatctcccg caccggtgac gacggccgca
     4621 tcgacggcac cgtcagctgg taccgggaga ccaaggcgaa cggccggcac cgcgccgagc
     4681 tgcgcaagct gatggtgcac ccggcggccc gcggccgcgg caccgcccgc gccctgctcg
     4741 ccgaggccga gtcggccgcg gcccgcgccg gggtggtgct gctgatcctg gacaccgaga
     4801 ccgggagcgg cgccgagcgc atctaccgct ccgccggctg gaccgaggcc ggcaccatcc
     4861 ccgactacgc cagcgacccg gcgggccggc tgcaccccac caccctgttc tacaagcagc
     4921 tccgcagcgc ccacgggtga cctcgtccgc cgcgcggcgt tagaccccgt agccgccggc
     4981 caccgagtga gggagaccgt atgtccgccg catcgcccgc cgcacccctg acccgccgcg
     5041 cgcttctccg tacggcgttc accgcggccg tgctcgccgg tgcgggtgcg gccctggccc
     5101 ccgtgctgcg cgcccggcgc ccccggcaga ccctcacccc ggcgccgctc gccgaggagg
     5161 agacgtaccg cggccgccac atcgccgtcg acgtcgccgg ggtccgtatc gacgggcggc
     5221 cgctgcacgt catgcgccgg gccgacggca gttacctcag cgggatcaac cacttccagt
     5281 cgtatccgac cccactggaa ctggccaggg ccgccgtgga cgagctgggc acggcccaac
     5341 tcgccctcgc ggcaccgcac cacggctgac aggcacacgg gaacgggagg accccgcatt
     5401 gcacacccgg cagaaccaga agaacctcac cagcgcccag aagaagcgct tcacggcggc
     5461 ggtgctggag ctcaagcgca gcggcgccta cgacgcgctg gtgcgtaccc acgacaagta
     5521 cttcgtgccg gaccgcgacc gcaagctgcg cgtcgggcac atgtccccgt ccttcttccc
     5581 gtggcaccgg cgctatctgc tggagttcga gcggcagttg caggagatcg acccgggcgt
     5641 cagcgtcccg tactgggact ggaccaccga cagcagcccg gcctcctccc tgtgggccga
     5701 cgacttcctg ggcggtacgg gccggacggg cgaccgcaag gtgatgaccg ggccgttcgc
     5761 ctacgacaag ggcaactgga cggtgacggt gggcatcacg gagtccgcct tcctcacccg
     5821 caacctcggc cggccgcaga accccatcac cctgcccacc gcggccgagc tccagtgggc
     5881 gatcgacgat ccgacctacg acgtcgcgcc ctgggactcc acggccaccg cgggcggttt
     5941 ccgcaacaag ctggagggct gggcggcccc caagagcgag cgctggcgca accacaacaa
     6001 ggtccaccag tggatcggcg gccacatgac gggcggcacg gcgcccaacg acccggcgtt
     6061 ctggctgcac cacgccttcg tcgacctgat ctgggaccgc tggcagcaga agcaccccgg
     6121 ctccggctac ctgcccgccg cccccctggc cgtcggcgac ctccagcgcg gccgggtgat
     6181 cgcccgcgac gagccgatgc cgccgtggaa catcaccccg cgcgagatgt ccgaccaccg
     6241 gagcctgtac cgctacgaat gaccgtggcg gcgggcacgg gaaagggccc ccgccatccg
     6301 gcgggggccc ttccgtggat cagccgatca cccgatcagg ggatcagtgg ccgtagtcgc
     6361 caccctcggt gtggtggtcg ctgccgccgc cggaggcgtt gacgcaggtg ttgccgaacg
     6421 ccgggttcag cagagcgatc acgttcacgg tgttgccgca gacgttgacc gggacgtgca
     6481 ccggaacctg gagcaggttg cccgagagga caccggggga gccgaccgcc gcaccgtgcg
     6541 ctccggcatc ggcgacagcc agacccgcac cggcgaccac ggcgctgccg gtgacagcgg
     6601 tgatggcgaa tgccttcgcg atacgcgaca tcaagatctc ctcatgagat atgtggggcg
     6661 ccacagaatc tgtggcattt gacatggcat acaacgcggg ggcggccgag gggtcacggc
     6721 cgctgcgcct acccggtgac agaaaaccgg acggaggcga agtacggccg cacctggccg
     6781 acctccccgg gccgcagaac ccgcagcacc cggcccgaac acccggggcc ctcgaagagc
     6841 gtcgccgagc cccgggtccc gttggtgacg gcccgggcgc cgccgccctc ggcctcgaca
     6901 caccccttcg gcgcggtgag gccgtggacc cggtcgtcct ggccgacgta ctggaagtcc
     6961 gggccgacgg ccacggccgg gccggacagg agggtggcgc ccgcgagcag cacggcgacg
     7021 ggcacggcat ggtggatacg caggaatcgc atgcccgtcc aaccgggcgt gaccgggacc
     7081 cggtcacgcc ttgtcacccc ttggacggct gtgcgaccgt gcgaccggcc ccggcaccgc
     7141 aggaggacca gatgagcgca gagccctacg gccaccgccc gcgcgtcagg accgcgggcg
     7201 gtgtcgtgga gggccggacc ggccccggcg ggaccgccgt cttcctgggc atcccgtacg
     7261 ccgccccgcc cgtcggcgcc ctgcggttcg cggcgcccgc gcccccggcc gcctgggacg
     7321 gtgtacgcga cgccgcggcc tacgggccga ccgcccccaa agtgccgtac ccggacacgt
     7381 tcgccgcgct gctccccgac cccgtgatcc ccggggacga ctgcctgaac ctgaacgtgt
     7441 ggacccccga cccggccccc ggcgcccggc tgcccgtcat ggtgtggatc cacggcgggg
     7501 cgcacacccg gggctcctcg gcggtccccg tgtacgacgg ctccgccttc gcccgcgacg
     7561 gggtcgtcct cgtctccttc aacttccgcc tcggcgtcct cggctacggg ctcttccccg
     7621 acgcccccgt caaccgcggc ctgctggacc agatcgccgc cctcacctgg gtccgcgaca
     7681 acatcggggc cttcggcggc gaccccgacc gcgtcaccgt cttcggggag tccgccggcg
     7741 ccatcagcat cggctccctc ctcgccgccc cgcgcgcggc cgggctcttc tcccgcgccg
     7801 tgctgcagag cggagccccc gaggtcctgc cgcgcgtcag ggtccgcgcc atggtccgcc
     7861 ggatggcctc gctgctcaag gtggacgcca ccgccgcggc cttcacggcc accccactgc
     7921 ccgacctgct cgccgcccag ggggccgtcc tgcgccgctc gggcccgctc ctcggcggac
     7981 ccgccttcgg cctggtcacc gacccggaca cggtccccac cgaccccctc gacgccctct
     8041 gcgaccgcgc cgcctccacc ggggtgccgc tgctcctggg ctggacgagc gacgagtacc
     8101 ggctgtggct cgcccccacc ggcgggatgc gcctgctgga ccggctgggc ccgctctcgg
     8161 tcgcgctggc ccgggcccac gcgggcaagg accgggcggc cgtacgggcg ctgcgcaccg
     8221 ccctgcccgc cgcgaccccc gccgagctgg ccgggcagct gctcaccgac cggctgctgc
     8281 gcgacccgct gcgcaggctc gccggggcac ggcgggcggc gccgagcttc ctgtacgagt
     8341 tcggctggcc ctccggcctg ccggggctcg gcgcctgcca cgccctggag ctgggcttcg
     8401 tgttcgacac cctcgcggca ccggaggcgg cctggctggc cggggcgcag cccccgcagg
     8461 cgctggccga cgagatgcac gcggcctggg tgcggttcgc ggtggagggc gatccggggt
     8521 gggcggcctg gaacggcgac ggcccgccga agatgttcgg cgggccgtcg ctcgatccgg
     8581 agcaggcgcc ggtgattact cgaccggtcc ttccatgacc ttgctgatgt actggatcgg
     8641 cccctcgccc atgttcggga cgtaggtctt cgcgttgtgc tggccgccct tgatgaccct
     8701 caactcggtg tggaccggac ccttgttgcc gtaggtcgcg atgaacttct gcacgtccgg
     8761 cagggtcttc ttgttgttct cgctgtcacc gacctggaag gccaggtaca cgtccggccc
     8821 cttggtgtcg atgagctgct tggccagcag ctccgggttg ttctccgcct tctccttctc
     8881 gtggcccttc cacagggagg agtccgggac gatgtccgga ccggaggcga tcacggcctt
     8941 gaacttgtcc gggtgcttca gcacggcctt caggcccgcg aacccgccgg tggaggagcc
     9001 catgaaggcc cagccgtcac gggacttgac ggtccggaag ttcgccttca ccaggtccgg
     9061 tacgtcctcg gtcagccagg tgcccatctt gggctggccg gggatgtcgg agccgtccca
     9121 gtagatgccc ttgtcgtccg gcgccgggtt gaggaccggc atggccagga tgaagggctt
     9181 gctcttgccc tccgtgtacc acttgctgat gctggtctgg aggccgaggt cggtgcccat
     9241 ccagtagttg ctggggtaac cggcgccgcc cggcagggcg atcatgaccg ggaagccgct
     9301 cttggcgaac ttcgggtcgt tgtactcctt gggggcccag acccagacct tgcccttgaa
     9361 gccggacttc ttgccgtcga gcgtggtgac ggccacgtgc gtgccgtcgg ggagcgtcat
     9421 cgagttcttg aactcggcgg ccggccccgt cggcatgagc atcttggagt tggccggcgg
     9481 cggagcgtcg tccttcttgc cgccgcccgc gggcgtctgc ccgaacgaca ccgcggagcc
     9541 cttgtcggtg aaggggggta tctcgtagtg gttcagcacg agcgcggccg taccggcgag
     9601 cgcgaggacg gcggcgccgg ctatgagcca gcggcgtccc ctgcggcggc gcggcggctc
     9661 ctcggggtag aggtcctgcg gtccgtaccg cgccgtctgc tcgtacgggt cctgcggtgc
     9721 gtactgcgcc tgctgcccgt accggtcctg ttgcccctgg ggctgccggt gcggctgctg
     9781 tccgtacggc tgggcgtacg ggtcgccgtg gggcggctgc ggtatctgtc cttccggccg
     9841 gtacggctgg tactgctgcc cgtcgggtgc gtacgacatg tgcggtggct ctccggctgg
     9901 tgctgcccca gaggggcggg gtggtctgac tgctgggtcc ttccgttcga aggatgaacg
     9961 aaagcatgtc agggttccgc acttttcctt ctcttggggt gccctggggg aggccattgc
    10021 ccggcgcccg cagggtcggt ggagttcacg gtcccgcccc cgtccatgcc tggcccttgt
    10081 ggatcccgct gggtatggtg cccccgcgcc gcccccggaa tcccaccccg ccccggagtc
    10141 ctcccatgac gctccagcgc cggatcctga tcctggccac cgccgtggcc ctgctcgcgg
    10201 cggtctgcgt actggccgtc gtacgggcct cctcgcgcgc cgacgagaag gaccatgccc
    10261 gggccggcgg cccgcagatc gctccgggtg cggtctcgct ggcaccgggc gacggcggcc
    10321 ggcggatcgt gttccgcaac atggcgtggg ggccgcaccg ggacgagctc gccaccgtcg
    10381 cggccggcgc gcccgggggg acccgtaccg cgtccggggt gagctgcctg cgcttccacg
    10441 cggccggggg caccgggatc tgcctccagg cggaccggaa cggcgtccag gagggctatc
    10501 gggcgctcgt cctcgacgcc cggctgaaag agatctccgc acacccgctg ggcggggtcc
    10561 ccacccgggc gcgggtctca cccggcgggc acctggccgc ctggaccgtc ttcgtcggcg
    10621 gggactcgta cgcgggtacg gacttctcca cgcggacctc ggtgctcgac ctgcgcacgg
    10681 gccgcctgga ggcctcgctg gaggagttca cgatcctcaa ggacggcaag ccgtaccgcg
    10741 ccgccgacgt caacttctgg ggggtcacct tcaccgccga cgagcggacc ttctacgcga
    10801 cgctcgccac cggcggccgc acccacctgg tccgcggcga cctggtcgaa cgcagcgtga
    10861 ccaccctgcg cgagaacgtc gagtgcccgt cgctgtcgcc cgacgggacc cggctggtct
    10921 tcaagaagcg ggtgccgggc ctgccggccg aggtgccctg gcggctgtac gcgctggacc
    10981 tggcctccgg cgccgagacc ccgctcggcg aggagcggag cgtggacgac caggtggtgt
    11041 ggatcgacga acggaccgtc gtctacgccc tgccggggga cttcggcgcc gacctgtacg
    11101 ccctgccggc cgacgggagc ggcgcccccg cccggctcat ggactcggcc ctcgccccgg
    11161 ccttcctcgg gtgaggaggc cgtggcgagg gccggggcag gaccgttttt ccgctcgtgc
    11221 ggccgacccg ccgccctacg cggggacgag ggtcttgcgg cggcgcttgc gctgcgcgcc
    11281 cgccgacagc ctcagctcga tgatcgaccg tacggccggc cactcctcgt cgaggatcga
    11341 gtagaaggca gtactgcgga ccgcgccgtc gagcccgcgc gaatgggccc ggcggacccc
    11401 ctcgcaggtg aagcccagac gttccatcgc ggcccgtgac cggccgttgc gcgcatcggc
    11461 acgcagcgag atgcgccgca ccccccaggt ctcgaaggca tggcggagca tgagcagctt
    11521 cgcctcggtg ttgatgccgg tgccctgggc gcccggggac agccaggtat tgccgatctc
    11581 ggcggcatcg gggatcgccg tcgccggatc gccgaacggg acgccgggca cggcgggcca
    11641 gaccagcggc ccttgccagt agtcgagttc caggaaccgg gtcgaaccga cgacccgccc
    11701 gtcggtggct ctgaccaccg cgaacgggag cgatcgaccc gcagcctgat cggcgagggc
    11761 acggtcgatg tactcgtggg acgcctgcac cccgtggggt acgggagtga aggcgtaagt
    11821 cgtacgatcc tcggccccgg ccacggccag agcctcggtg tggtgggggg cgaggggctc
    11881 gagccgcacg gtgcggcccg cgaggtgtac gggtacgggc acggagcctt cggtccttct
    11941 gggcggtggg gtggttgcac agtctgcgtc catgacgtcg ccccccgtgc aaaacacgag
    12001 tgaaaggcaa ccggctgtca ggtgaacgcg agtggctcaa tgtagcccct aaaagtcctc
    12061 tcatgaaccc ccaatttggc aatggcgtga caccgatttc cgatgacttc ggtccccgct
    12121 tccgagcgcc cgtaatcctg atcaacggac atcccttccc ccgcacgacg cgggcccccc
    12181 ggacggccgc gccgaccacc gccgggtacc gtgcgagcac gtctgacctg cggagatgca
    12241 aggaaagccc gaggggcccg ggcagggcgc ggcgggcgga tcccacggac ggtcccgccg
    12301 ccccgccgac cggtccgggc atcgaacacg tggtcgtcgg tggtgtgtcc gtggacggtc
    12361 ggatcgccgg gcaggtacga ctgcgccacc cgggtctgct acgggcccgg cgcgctgcga
    12421 caccccgccc gatccgggcc ccgagccact gggatcattg cggccatgga cgacgtactg
    12481 cggcgactgg ccgccgtggg gcccttcttc accgtcccgt acgggacgga gccgcccggc
    12541 cccggcttcc ggccgctcac ggcgctctac ggggagcggc tcgcgccgta cgtggccgag
    12601 gtggggcggc ggatcggcag cggtcccggc cgggtggcgg cctcgaccgc gcagttcggg
    12661 atcgtctccc ggctctggtc gctcgggctc gggtccgcgg cgctgggggg ccgggtaccc
    12721 gacctgtccg ccgaccgggt gtggtggcgg atgccggacg ccgggtcgct ccagctgtgg
    12781 ctgcccgagc cgggtcccgg cctgccggcc gaggagctcg ggcggaacgt cctggccaat
    12841 ctggccgcgc tggacgcggc cctgcgcgtg cgctacgggg tctccgcgca ggtcctgcgc
    12901 ggcaacgcgg cgtccgggct ggtcggggcg ctgcgggtgc tgatcgaccg ggtgccgggc
    12961 ggcgcggccg tggagctggc gggcgccctg ctggccgacg gcggggcgct ggcgggcacc
    13021 ggcaccttca tccacgagga ggggctcggg gtggccttcg aacggcgcag ttgctgcctc
    13081 tactaccagg tgcccggcgg cgggctctgc ggggactgcg tgctgcgcgc ccggcggcgg
    13141 ccggaccggc ggcgggcctg accgcacggg ccaccgcagc acgcgtcacc gccgcacgcg
    13201 gccgttcgga gcaagggagc gcgcgccgca ccccgacccg ccacgggccc ggcgtacggt
    13261 ccgctgcatg accgctcgca ccccccaccg gcccgccgcg ctcacccgcc gtgcggccct
    13321 cgccgggctc gccgcgggcg ccggggcgct cgccgccggc ggcaccgccc gcaccgcgac
    13381 cgccgccccc gggccgtccg cgaaggccgc cgatcccacg cccggggcga tgcagctctt
    13441 cgacgacccc ggcttcaact tcgcgggcct gctcgcactc ggcgccgccg ggatgcgcgc
    13501 ctccgaggtg ggcgaggtac tgaccgcggt gaacgcgatc aacgcggccg gcccgtccga
    13561 gcacaccttc agcgacacct tccgcgcctg gggcgaccgg ctcgccgcgc ccccggccgc
    13621 cggccgccac ggtcacgagg ccccctccca gacccgccgc ttccgctccc tgcgggccgc
    13681 ccagtactac gcgcaggcgc tgttctacgt gctcggcacc gaccaccccg gtgacgagga
    13741 ggccgtctac ctggccgggc gcaaggcctg ggacaccttc aaccggctgt gctcaccggc
    13801 cgccgtccgc gcgaaggtcc cgtacggccg gacgcacctg ccggtctggt tcttccgccc
    13861 ggacggtccg gcccggccgc gccccaccgt gatcctcacc aacggcagcg acggccagaa
    13921 cctggacatg tggacctacg gcgtgtccgc cgccctcgac cggggatgga acgccctcgt
    13981 ctacgacgga cccggccagg gccagctgct gttcgtggag gagatcccct tcaccacccg
    14041 ctgggagaag gtggtcgccc cgctcgtcga ctggctggag gcccgacagg acgtggacag
    14101 cggccggatc gcgctcacgg gcctgagcat gggcggaaac ctcgtcgccc gcgccgccgc
    14161 cttcgagcac cggctcgcgg ccgtcgcctg ccagccggga tgcgtcagcc cctggctggg
    14221 cttcgacgcg gagctgcgcg cgatcatcac ccccgacaag gaggagacca accgggtctg
    14281 gaacgaggag gtcgtcccgg aactgacccc gcagctcgcc ttcaccgtca agaagcgctt
    14341 cgagatcttc gaccggcagg cactgcgcca ggcccgcgag ggcgtcgtgc tcacggacgt
    14401 ctggaccccg gcgcaggtgg ccatggggct cgacatcacc gaggtggtgg gcaggatcaa
    14461 ggccccgacg ctcgtcctgg actacgactt cgaactgttc tacccgggcc agccgcagca
    14521 gatgtacgac ctgctgcgca cgcggcgcga gtacgtgaaa atgacggagg ccaccggggc
    14581 gcagttgcac tgctccccga tggccccgca acagcactgc gacgtcgtct tcgactggct
    14641 cgccgacgtc ctccgacgca ggtagtactc ccgccggaac ctctagaagg tcaggttcca
    14701 ggagtcgatc ctgccggtgt cgccgccggc gttgtcgttg acccgcagct tccaggtgcc
    14761 gttcgcgacc tcggaggagg cgttcacggt gtagacctgg ttgatgttgt cggtgctgcc
    14821 gccggcacgg ttgtgcacgg tgtagacggt gccgtccggc gcgatcaggt cgaccttgag
    14881 gtcaccgatg taggtgtgca cgacgttcac gcccaccttg agggtggccg gggcgttgcc
    14941 cgtgacaccg ctgacggtga tggggctctc cacggtggcg ttgtcgccga tggcgaagtc
    15001 gccggcgttc tcgaagtact tgccgggcgg cggggtgctg ccgacggcct tcagcgcgtc
    15061 gacctggccc tcgccgaaga agccgttctt cgccgtggtg cccttgcagc ggccgtccga
    15121 cgggcaggcg acgtcgttgg cctgggtggc cagcttgtcg cgcagctgcg ccggggtgat
    15181 gcccgggttg gtgctggcca gcagggccgc cacaccggcg acgtgcgggg acgccatcga
    15241 cgtaccgctc atggagccgt acttgccgcc cggcagggtg ctgtagatgc cggtggcgtc
    15301 gccgccgggc gccgtcacgt cgacgacgtt caggccgtag ttggagtacg aggccttcgc
    15361 ggtggtgccc atcgccgaga ccgtgaccac gcccgggagc tcggtcggga tgtccaggca
    15421 ggcgttggtg atggtgcggg tgaccggcgt cgagtcgttc gggctctcgg tgtcggtcgt
    15481 cttgttggcc aggtcgatgt tggagttgcc ggccgccgcg acctgcagcg agcccttgcc
    15541 ctccgcgtac tcctgggcgc gcttgacgcc ctcgatgatc gcggcctggt cggcgttgtc
    15601 cgggcagttg aactgccacg ggtccgtgta gtagctgttg ttggtgacct tgaagccgtg
    15661 gtcaccggcc cacatgaagc cgcagaccgt gttctcggcg aagaagagcg aggaggtcgg
    15721 ctcggcgatg cgcaccgagg agatcttcac gcccggcgcg acgccgatga cgcccttgcc
    15781 gttcttggcg gcggcgaccg tgccggccac gtgcgtgccg tgcgtgccga cgtcccgcca
    15841 ggcgccggaa cgggtgtccg gcttgccgta ggcgcaggac gcggagtccg ccgcgttgaa
    15901 gttcggggcc aggtcctggt gctggtcgtc cacaccggtg tccaggatgc cgaccttgac
    15961 ggaggcggaa ccggtggtca cggcccaggc ctggtcggcc ttgatctggg tcatgtccgc
    16021 gcggaccggc tcgcccgaag gcgtcgtgga ctgcgccggg ttggcgggca gcgccgggtt
    16081 gtaggcgtcc gccggcacgt ccgaggtgcg ggtcgcgccg acctgctgga ccccgctcac
    16141 accgcgcatg gtggtggcga aggtgccgga cgcggagtgg gcgatgatca cgccgatcgc
    16201 gtcgtagtgg ttgaacaccg tgccgccgtt ggcggtgacg gcgctgcgca ccgccgtggt
    16261 gtcaccgggg gcggtgatga cgaggtaggc acgggtaccg gcaacccagg tcgcactctg
    16321 ggaagtcggg gccgcagcct tgggggccgc cgcgggggcg ggggccgagg agccgttcgg
    16381 cgcgacgggg gcggtgccgg cgagtgcggc gggggccccg aaggcgagtg ccgcgccgag
    16441 tgtggcggcc agcacgaggg tacgtcgagg tcggctggat atgtggggta tcaatgcgtc
    16501 ctccgaagac ccggtggtca ggccgggtcg aacgaaacaa gtggtggacg caagatgtca
    16561 tgcacacagc ctgttacgga agtacctttt acagcctggg ggttcggtta tcggtggccg
    16621 aataccgact atgggtgcaa gtggggagaa tgcggcgggc cgaccgggct gggcaccgtg
    16681 ggggcgagcc ctgcccggtc ggcccgcggg ggcgcaccgg ctagaccggt accccgtcct
    16741 tggggttgat cgagggctgc ggtacggaat tcggggttcc gtcggatgcg tcgctcccgg
    16801 tggctccggt gggcccggtg ggctgcgcgg gttcgccctt ctgctgtgcc ccgtgcccgt
    16861 cgtcgacgag cgtgctctcg tcgaagggca gccgtcccgc gaggacttcg gaggcccgtg
    16921 cgtggtcgaa ctccttcgtc caggtcccga tgagcaccgt cgcgaccgcg ttgcccgcga
    16981 agttcgtcag ggcccgggcc tcgctcatga accggtcgat gcccacgatc aggccgacgc
    17041 cgtccaccag ttccggccgg tgcgactgca gcccgccggc gagggtggcc aggcccgcac
    17101 cggtcacccc ggccgcgccc ttcgaagcga tgatcatgaa cagcaggagc gagatctgct
    17161 cgcccagcgc gagcggcttg cccatcgcct cggcgacgaa cagcgaggac atcgtcaggt
    17221 agatcgcggt cccgtccagg ttgaaggagt agcccgtcgg cacggtgatc ccggtgaccg
    17281 gccgcgagac ccccaggtgc tccatcttcg cgatcagccg cggcagcgcc gactccgagg
    17341 aggaggtcga gaggatcagc aggaactccc ggccgagata gcgcagcagg gcgaagacgc
    17401 tgaccccggt gcacaccctc agcagcgtgc cgaggaccac gaacacgaac agcagacagg
    17461 tcgtgtagaa gccgatcatg atgacggcga gggacttcag cgcgtcgacg ccggtggccc
    17521 cgaccaccgc cgcgatcgcc ccgaaggcgc ccaccggcgc cgcccacatg atcatcgcga
    17581 gtacccggaa caccagcttc tggatgtgcc cgataccccg cagcaccggc tcgcccgccg
    17641 cgcccatggc ctggagggcg aacccgcaga gcagtgccac cagcagcgtc tggagcacct
    17701 cgcccccggt gaacgccgac accatcgtgg tcgggatgat cccgagcagg aactccggcg
    17761 tgctctccgc cccgcccgcc ttggcctgtg cctcacccgc actgcgcgcc gcctcggtca
    17821 ggtgcagccc gctgcccggc tccagcaggt tgcccaccag cagaccgatg gccagggcca
    17881 ccgtggacat gaccatgaag tagccgaggg cgagcccgcc cacggcgccc accttggcgg
    17941 ccttgcgcac ggatccgatg cccagcacga tcgtgcagaa gatcaccggc gagatcatca
    18001 tcttgatcag gttgacgaag ccggtgccca gcggtttgag ctccacggcc acgccggggg
    18061 cggcgaagcc gacggcgatg ccgagcagca ccgcgccgat caccgcgatg tagagatagt
    18121 gcgttctgtc gcgtctggcg gccacgatgc ctcccggtgg tgattgcgtt cggggagacc
    18181 atcgcccagg gctgtgaccc cggtcaccct tgcgttcatt gagttcacga cccggtgcac
    18241 actgagcgcc atgttccgct tccctcgacc cccgcgcagc ctcgccggcc agctcttcgc
    18301 catgcaggtg ctgctggtcg ccgtggtcgt cgcgggctgc gccgtcttcg cttatgcgac
    18361 cgcccggagc caggccgagg aggccgcccg ccgccaggcc ggggcggtgg ccctcgcggt
    18421 cgccgactcc ccgtccgtgc gcgaggccgt acgggcggcc gtgcgcggga ccgacccgtc
    18481 cgtcgcgctc cagccctacg ccgagcaggt ccgcgtggac tccggcgtga acttcgtgac
    18541 gatcatgtct cccgaggggc ggcgctggac ccaccccgac ccccgccgga tcggcgagcc
    18601 cttcatgggc aacaccgccc gggcgctgcg cggcgagacc ttcagcgaga cgtacaccgg
    18661 caccctcggc ccgtccatcc gcgtggtgac cccgctgcgg gacgagggcc gcatcgtcgg
    18721 cctggtcagt gcggggatca ccgtccgcac catcagcgac cggctcgcca cccagctctc
    18781 cgccctcgtc tgggtcgcgg gcggcgccct cgccctcggc ggggtgggca cgtacgtcgt
    18841 caacgcgcgg ctgcgccgcc acactcacgg tatgaacgcg gccgagctca gccggatgta
    18901 cgactaccac caggcggccc tgcacggagt ccgcgagggg ctgctcatgc tcgacgggca
    18961 gcgccggatc accctgatca acgacgccgg acgcgagctg ctggccctgc cgggcgacgt
    19021 caccggtacc ggggtcgccg acctgggtct gccggccccg ctcaccggcg ccctgctcgc
    19081 cgaccggccc cgcgtggacg aggtgcacct gaccgccgac cgggtgctgg tggtcaacag
    19141 ctcaccggtc gcgggcggcg gccgccgggg caccgtcgtc accctgcgcg accacaccga
    19201 actccaggcg ctgaccggcg agctggacca cgaacgggga ttcacccagg cgctgcgctc
    19261 ccaggcccac gaggccgcga accggctgca caccgtggtc tcgctcatcg aactcggccg
    19321 cgcggacgag gcggtggact tcgccaccgc cgagctcgaa ctcgcccagg cgctcaccga
    19381 cgaggtggtc acggcggtgg gcgagccggt gctggtggcg ctgctgctgg gcaaggccgc
    19441 ccaggcgcac gagcggggcg tcgagctggt ggtcaccgcc gacagccgca gcctcgccga
    19501 agggggcggg ctgccgccgg cccgggacct ggtcaccgtg ctgggcaacc tcatcgacaa
    19561 cgcggtcgac gcgctcaccg ccgtaccggg cgcgcggatc gcggtgacgc tgcggccgga
    19621 gccgcagggg ctgctgctgc gggtcgcgga caacggaccc gggctgcccg agggcgtgga
    19681 cgtcttccga cggggctggt ccggcaaggg ggagggccgc ggcctcggtc tcgcactggt
    19741 ccggcaggtc gcggagcgct acggcggagc cgtggtcgcc gcgccgggcc cgggcggcgg
    19801 ggcggagttc accgtccgcc tgccgatggc gcccgcagcc gggacggacc cgcgggaccc
    19861 gggcgacgtg gccgatccgg cggacctggc cgacccggcg gacgcggcgg gcccgcggtg
    19921 agcgcgggcg aggtgcgcgt gctggtcgtc gaggacgatc cggtggcggc cgacgcgcac
    19981 gcgctgtacg tcggccgggt gcccggcttc acggccgtcg gcgcggtcca ctcgctcgcc
    20041 gaggccaccc gcttcctgga gcggacccgc gtcgacctgc tcctgctcga cctcggcctg
    20101 cccgacgggc acggcctgcg cttcgcgcgc gggctgcggg ccgccggtca tcccgtcgac
    20161 gtgatcgtgg tgacctccgc gcgggatctg gccgtggtcc gcgagagcgt ctcgctcggc
    20221 gtggtccagt acgtactgaa gccgttcgcc ttccccaccc tgcgcgaacg gctgctgcgc
    20281 tacgccgagt tccgccaggc ggcgggcgag gcagccggcc aggacgacgt ggaccgggcg
    20341 atggccgccc tgcgcgcacc ccgcccggcc gagctcccca aggggttgag cgcgcccacc
    20401 ctggaccggg tcgccgccct gctgcgggcg gcgcccgagg gactgacgtc ggcggggacg
    20461 gccgaggcgg cggggatctc ccggatcacc gcgcgccggt acctggagca cctggtggac
    20521 accggccgcg cggaccggac tcccaggtac ggccaggtcg gccgccccga actgcactac
    20581 cgctggctgg ccgcggccac cggctcggtg tcgaaggtgt agaacttccg gtggtccagc
    20641 atgtccgccg gggtcacgtt gttccagggc cgcatggtgt cgttcaggtc gacgacgttc
    20701 tgcgtgcccg cgcccgggag gtacgtggac tcggggtgct tggcctgcca ttcggcccac
    20761 agcttgtcga tgaaggcgtg gtgcatccag aacaccgggt cgttggggga gaccccggtg
    20821 gacatctgcc cgccgaccca cacgtgcacc cggttgtgca ggttggcgcc gcgccagccc
    20881 tccaggttgt tgcggaagcc gttggaggag ctgttccagg gcgccatgtc gtagaccggc
    20941 atggcgagga cggcgtccac ctcggccctg gtcggcagct gggcgacgga ggtgcccaga
    21001 tcgcggcgca ggtaggcgcg cccgtccacc cgtacgttta tgttccactt gcccgtcgcg
    21061 tacgcgaacg ggccgtccat gacctggccg tcacgggccc ggccggtgcc gccgaggaag
    21121 tcgggggccc agagggagga gcgggaggtg cggtccgccg tccagtccca gtagggcagc
    21181 gcgaggctcg cgtccacttt ctgcagcgcc tcctcgaact ccaggaggaa gcgccggtgc
    21241 cacggcagga aggaggggga gcggtggccg acccggtcgc ccgagtcggt gtcgctcatg
    21301 atgaagccgt tgtgggtggt gacgaaacgg tcgtagctgc cgttgcgctt gagctcctgc
    21361 agggccgagg tgaaggcgcg cttctccgcg ggcgtcagcg tggcctggtt cttgcgtacg
    21421 gtcatgccgc acctccgaag ggaacgaggg cggcgccctg gagatcgcgg accgcggcac
    21481 gggcgaggag cttcggctcg gcgaaggtct cgtagtggtt gatcacgctg atccatgtgc
    21541 cgtcggcgtt gcgcatgatg tgcagttctc tgccgtctat tcggacggtg ggttggcccg
    21601 gggagtggtg gccaccgtga tggccgccac cgcccggggt gatctggata cgacggccct
    21661 ggtagacctc gtcgaccgtg cccggggtgg tgggctcggc gggggtcgcg gcggcgctcg
    21721 tggcgcccgc ggcggcggcg gtcagaccaa gggcggtgag agcaccggca gttgtcccca
    21781 gggcctgacg gcgagtgatc ttcttcatgg cacgaagagg tatcagggcg ggggagtggc
    21841 ttggccggta tccggacatg gacggataag ttgccggtag aacaagttgg atgatcttcc
    21901 cgtccggagc ggctccgggg gtccgaacgg gaagatctgc gggatgaact ctactcgaca
    21961 gtaatttctt ctggtcgggc ggggcgctat gtgcaggatc acactacaga gtcggccgga
    22021 agcagagcgt cagaatctgc ccggggatgt gctatgtgac tacggggtgg agggggccgg
    22081 gacgtccgga agatccttga tgaacacgac cccgtccatg gaggccaagt gggccgggtc
    22141 gagcggggcg tagccgaacc agggggacac ccgtggcgcg ggcggcgcac cgccgaggac
    22201 ggtcgccagc tgtcgggcgt cgacgacgca ggggtcgtcc gggagtgcgt acaggaggcc
    22261 ttcgacggtg tccggcggcg gcgcgtccac gctccggtgc cggatggtgc cgagggccgt
    22321 ggccacgaag gcgtactccg tgccgagccg ggcgctcacc agcgcaccgg cgctccacca
    22381 ctccagcagc ctgccgccca tccgcatcga gctcttctcc cgctggaggt gggcgttgtg
    22441 ggcgtggacg aggaccgggc cccgggcggc gagggcgagg aggttgtcgg ccatcatccg
    22501 gccccgcagg cccaccagcc gggtcatgcg ggccggtgag gtgtcggcca tccagcggtg
    22561 gtagcgcagc aggtcggtgg ccgtgcgtcc gtacaggcgg gcccggtcca ggtcctcccg
    22621 ggaggtcgcc gccagcaggt gcggcgtgtg ctcctccagc agcgccacca ggtcgtcggc
    22681 gagcagccgc agctcccggg cctcggccga gccccccgtg gaccgggccg ggtccatcat
    22741 cgcggcgggt tcggtccacc ggtcgtcggc gccgagcagg cggtcgagcg cgggagcggt
    22801 gcaggggagc agcccggcgt ccaggtggcg ggcgaggtgg tcgtggagcg cggtgagggc
    22861 ccgccggggg ctcgcggcgc ccgccatctc caacgggccg tcgatcccgg cgaagcggag
    22921 ctgctcgggc gcgggccggc cctcgttgaa cgcccgcatc cagcggacga gttcgcgatt
    22981 ggcggcggag gcgccgaacc cgtggctgaa gccgcgctcc atcacctcgt cgaggctgcc
    23041 ggcgcccgag gtgacgtacg cgtcgaccag cagggccgcc agacagtcgc tctcgatcgc
    23101 gatcgtccgg tagccgcctt gcgcgacgag ctgccggaag agctcgttgc gcacctcgag
    23161 cagggtgtcc tcgccatggg tgggctcacc gagggcgagc agtcgtggcc gggccgcgaa
    23221 cggtccccgc agggcggcgg cgtcgagggc gcgggcggtg tccttgatgt cgatgggcat
    23281 gccttcaacg ctatcgctga agcctcggtg taaacttttc cgctctatcg tgggatccgt
    23341 gagccaaaac cttcaaagcg gccgacggct gcggccggtc gacctggcgc gcgggcacgg
    23401 tctctccacg caggcgatca ggaactacga ggaggccggc atcctcccgg ccgcggaccg
    23461 gaccccccac ggctaccgca cctacacact gctgcacgca cgcgccctgg ccgcgttcct
    23521 cgccctcgtg cagggccacg gccaccggac ggcggcatcg atcatgcggg ccgtgaacga
    23581 gggagcggcc gacgaggcct tccgtctcat cgacgggacc cacgcccaac tcctcgccga
    23641 ccggcggacc ctcgaagccg tggagaaggc cctgcgcgcg ctggagcccg ccgacggggc
    23701 cttcgagctc gacgcggtgt ccgccgctcc gtccggtggc accttcatcg ggccgctcgc
    23761 ccgcgaactc ggtctgcggc ccgcgaccct gcgcgcatgg gaacgcgccg ggctgatccg
    23821 cccgcgccgc gacccgctca ccaagtaccg cgtgtacgac gcggcagacg tccgcgacgc
    23881 ccgcctggcc catcaactcc gccgcggcgg acacctgctg gaagagatcg ccccgctgct
    23941 cgcccaggtc cgcgcggccg gcggcctggc gcccctcgag tccgccctga ccgcctggcg
    24001 cgcccgcctc tccgcccgcg gccgcgccct gctggcgggc gcggccgaac tggacaccta
    24061 cctccgggcc cgcgactgac cgccccgacg ccgtgggctg cagcccggcg ggtcgttcgt
    24121 cgtccggcgc ggggcgaacg acgggcgtcc gcgccgggtg ttccgtaccg accggaaagc
    24181 caccgcactg cgacggccgg atcctcgcat gctcggccgg gtagcgagcc accccccatg
    24241 cggctgccgc cggacgggag aagcggcccg ctcccgcccg gttcggacga cgggctctta
    24301 ggatcttctt aggggtgctt cctagtctcg ccgtccatga cgacccgacg actgtccgcc
    24361 gtgttcggcg ttctcctcgc tacggccctc gcgcacaccg gcctcgcgcc cgtggccgcg
    24421 gcggctccct ccggttccgg ctccgggcac ggggcccggc ccgccgcccc ggcccagtac
    24481 ctctactcct cgatcgggga cttcgattcc gaagtcaagc cgctggccga ccggcccgac
    24541 atcgcgggtg tgcaggtggt cgtgccgtgg aaggctctgg agccgcagaa ggaccagtac
    24601 gacttctccg cggtcgagga ggcactcggc tacctccagg cccgccacaa gaaactgttc
    24661 gtccaggtgc aggaccgctt cttcagtgct ccgacacggc tgccgaacta tctgctcacg
    24721 gacccggtgt acgccggtgg cgccgcagcg accacgaacg agagcggact ggggcccgga
    24781 gagcccggag ccgtcgcggc ccagtggaac cccgaggtgc gcggtcgctt ccaacgcctg
    24841 ctccaggcgc tcgccgaccg cttcgacggg cgcctggcgg gggtgaatct gccggagacc
    24901 gccacccagg tggatctggg caaggaccgc agcggctaca ccgacgagtc gtacttccgg
    24961 gccgaactcg acaacatggc cttcggcgcc aaggtcttca agcggacgca gttcatccag
    25021 tacgtgaact tctggcccgg tgagtggaac aacgaccacg gctacatgga gaagaccttc
    25081 cggttcgccg aggcccacgg tgtgggcctc ggcggtcccg acgtcctgcc gaaccgccag
    25141 gcgcagatgg agaactcgta ccccttcttc gagcggtacc gcgggcggct ccccatggtg
    25201 gcgatggcgg tgcaggagcc ggacttcgag tacatcaacc ccgcgaccgg caagccgtac
    25261 accaaggagg agttcgtcga cttcggcggc cggcgcctgg gcgcggacgt gatgttctgg
    25321 gcgaccgccg cgccgtggct ccaccggccc gggtcctgac cgccggctcc tgcggcccct
    25381 acggctgccg cggctcccgc cgttacgggc ggcccgggcg gaaggaacgg acggctcggg
    25441 cgaccaggcc gatccggcgg gcccacgtcg ccccgcccag ctggtccacg taccgtccga
    25501 tctgcgggtc ggcagcgcgc cggccggtct ccaactggac ggtcagcgcg agccggtaga
    25561 gctgctccag cacctgtgtc gccggcgcgg cgccgtcctc cggcaggggc gccgagagct
    25621 cgtaccggcc cgacgcccgg tccagggcca gacgtacgcc gcttcccgga tgtcccaccg
    25681 cggtgccgtc caccggggcg gccgtcggcc ccaggatctc gcgggcctgc cgcgcgatcc
    25741 tgtcccacgt ggcgagggcc gcgaccggac cggtcggggc gtcggacccg tggaagtcga
    25801 tcgtgtaccg tccgggcggg cgagccccgg ccggggcccc gtccgggagt gcgccgtccg
    25861 acgcgtcggg ttcgtccccg gtcggaaagc ggctgcgcaa ccacctttcg gtggccgccc
    25921 agtcgccctc gtcggcgcgg ccgacccacc tccgcagccg gtcctccgcc tcgaccagtc
    25981 cctccccgga gtcgacggcc cgctcgagcc cgtcctccag gtcggccagg gcggtcaggt
    26041 cggccaggtc cgcgggcttc gcgcaatagc ccggctccgc gttcgtcccc gctgccgctc
    26101 ccgggggcgg cagcagcgcc ggcgccccct cggcgcgtac gacgtcctcg gccggcccgt
    26161 ccggtgcgca ccttcgggtc agcacgaagg aagtgctgct cccgatctcc tgggcccgaa
    26221 cggagagcac gtccgggccg ggccgccagg ccacggcgca gcggaggtaa ccgtgggtcg
    26281 ggtccgccag gtgctcgcgg gccccggcga ggtccgcgaa cgtgtacagg taccggtcct
    26341 cgatgtcgtc ggcgaacagg aacacggcat cggcgcccgc gccttcgccc ttgccgggcg
    26401 cgtcgcccgc gtgggccagg gcgaacgcgg cgagctcgtc gagctgccgg cccgatgccg
    26461 ggctggggga catgactgtg ctgcctctcc gccgaccggt ccgtacgctg gatgatacgt
    26521 ggctgtgaac gctccgggtc tgctccggtt cgcgccgtac ggtccggctc ccgggccgcg
    26581 tgcccatccg gcctgcccgg gaatgttggt ttttgcgcct atagtcccga tatggctctt
    26641 catgagacga aggacgtacg cgcccaggac gccgacacgg acgtgttcgc gtccacgctg
    26701 agcggccaga tcctccccaa gtacaagatt cctgaggacc actcacccac cgaggtcgtc
    26761 tacgagctgc tccgcaacga gctgctcctc gacggcaacg cggcccag
//
