LOCUS       NZ_CP020039            20906 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces sp. 3211 isolate 3 chromosome, complete genome.
ACCESSION   NZ_CP020039
VERSION     NZ_CP020039.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. 3211
  ORGANISM  Streptomyces sp. 3211
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8232231)
  AUTHORS   Heinsch,S.C., Hsu,S., Hansen,L., Kinkel,L. and Smanski,M.J.
  TITLE     Complete genomes of three Streptomyces isolated from disease
            suppressive soils
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8232231)
  AUTHORS   Heinsch,S.C., Hsu,S., Hansen,L., Kinkel,L. and Smanski,M.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-MAR-2017) Biotechnology Institute, University of
            Minnesota, 1479 Gortner Ave, Saint Paul, MN 55108, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 20-JAN-2017
            Assembly Method                   :: PacBio v. Jan-2016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: PacBio; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 03:18:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,254
            CDSs (total)                      :: 8,154
            Genes (coding)                    :: 7,815
            CDSs (with protein)               :: 7,815
            Genes (RNA)                       :: 100
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 340
            CDSs (without protein)            :: 339
            Pseudo Genes (ambiguous residues) :: 0 of 340
            Pseudo Genes (frameshifted)       :: 206 of 340
            Pseudo Genes (incomplete)         :: 257 of 340
            Pseudo Genes (internal stop)      :: 68 of 340
            Pseudo Genes (multiple problems)  :: 153 of 340
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:04:45
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7741550
            Orig. end                         :: 7762456
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP020039.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Michael Smanski.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20906
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="33"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20906
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20906
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10906](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10906
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    3..18
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.63"
                     /tool="antismash"
     misc_feature    complement(303..312)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    426..435
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            complement(685..1503)
                     /locus_tag="B4U39_RS35195"
     CDS             complement(685..1503)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267907.1"
                     /locus_tag="B4U39_RS35195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glutamate ABC transporter substrate-binding
                     protein"
                     /protein_id="WP_030390541.1"
                     /transl_table=11
                     /translation="MKVPQAGAVAAVIAIALTASGCIGDDGDQGDGTLAIGIKFDQPGI
                     GMREVDGTFTGFDVDVATYVAKELGYKADKIEFKQVYSNDRELLIQYNEVKFVVASYSI
                     NEKRKEKVDFAGPYFVAHQDLLTRADDASINKPEDLNSKSLCSVTGSTSAENLRKNLAP
                     KAGLLELGGYSDCVVALQDSRVDAMTTDNAILAGYAARKGNENKFKLLGQNLSNENYGI
                     GVKKGNKELQRKINDALKKMVADGSWETAVKKNFGANYKYEPAPPITPVG"
     misc_feature    complement(1635..1649)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.38"
                     /tool="antismash"
     misc_feature    complement(1636..1649)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.17"
                     /tool="antismash"
     misc_feature    complement(1644..1661)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.57"
                     /tool="antismash"
     gene            1940..2482
                     /locus_tag="B4U39_RS35200"
     CDS             1940..2482
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016824387.1"
                     /locus_tag="B4U39_RS35200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TerD family protein"
                     /protein_id="WP_030390540.1"
                     /transl_table=11
                     /translation="MTGVRKGLAKVEFALRWDPSPAGAPANDLDIVAGVYGAADPHGTP
                     VQLVHFGSRSPDGTIALNRDSHTGQGFGFDEVMTIELNRMAPEAGRVVVGVVIQNSDAG
                     PEGRTKTFADIAGTGFRIREGHTDLAEGDFAAVAAATAATVAEFTRDASGAWSFDLWVR
                     GSDADPEEFARTMGALR"
     gene            complement(2728..3360)
                     /locus_tag="B4U39_RS35205"
     CDS             complement(2728..3360)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1224: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004980707.1"
                     /locus_tag="B4U39_RS35205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_079407243.1"
                     /transl_table=11
                     /translation="MTSPPTPARRSKITPEREQEFYDAVLEQLREHGYEALTMEGVAAR
                     ASCGKSTLYRQWKTKPQLVAAALRAGRRGTLVAVDTGSLAGDLREAARIAAGTSGRDTR
                     LTQALGHAVLSDEELQAALREALVEPELAAFAEMVGRAVARGEIAADHPAVEFLPAQLM
                     GVLRIRPVLEGRYADADYLVRFVDAVMLPSLGLVPSHPARPPAERAP"
     misc_feature    3412..3423
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            3514..4386
                     /locus_tag="B4U39_RS35210"
     CDS             3514..4386
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019984282.1"
                     /locus_tag="B4U39_RS35210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphatase PAP2 family protein"
                     /protein_id="WP_079407244.1"
                     /transl_table=11
                     /translation="MSSHTTPAEPAAAPRAARRRLIRELLLVAGFFAVYKAGRLLSTDR
                     TEEAFRNAGRIWDAERALHLPGEGLLQRLLLHGDALVTTANTYYAGVHFPATALFLIWL
                     YVRRPAHYLWTRRVLAALTAAALALHLAYPLAPPRLLDAAQLIDTAQVYGPSVYRAAPA
                     EDTLANQFAAMPSLHFGWALMLAVGVIAATSSRWRFLWLLHPLLTLIVIVGTANHYWLD
                     AVVAAVLLGAALLLVPKPRANDEPDDEPGDDADAAGPDPGATHENDPDGSVRGLPRPRS
                     ADAAVGAGQ"
     gene            4383..5285
                     /locus_tag="B4U39_RS35215"
     CDS             4383..5285
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012999259.1"
                     /locus_tag="B4U39_RS35215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DMT family transporter"
                     /protein_id="WP_237296941.1"
                     /transl_table=11
                     /translation="MNDTTLAVGLCLASAVAYAAGAVAQERLARAAVARTAGALMGSGA
                     WWWSAGLNAAAALLHAAALRYGPLTLVQPLGALTLVAAVPLGARRSGRRVVATEWRGTL
                     ATVAGLGLLLLPASGPAPDDTLTLIEALAVSGATIAVIMMLTAVKDPRSGLRHATASGL
                     ASAAASALTQTVAVAAGRGGALLSVRVVSVALLVVVFAVGGMLLSQRAYRGGLGAPLAV
                     VNLANPLAAAVIGMVLLGERLQGGLAGVLLAATGALLAARGVVLLTRTPSAPAGPGAGA
                     VTSAVAAAELPVPVGRVAV"
     gene            5378..5644
                     /locus_tag="B4U39_RS35220"
     CDS             5378..5644
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007380038.1"
                     /locus_tag="B4U39_RS35220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GlsB/YeaQ/YmgE family stress response membrane
                     protein"
                     /protein_id="WP_030390536.1"
                     /transl_table=11
                     /translation="MGIVSWIILGLLAGGIAKVLLPGRDPGGLIGTTLIGVAGAFIGGW
                     LSAKVLDKPIQTEFFDLATWGSAIAGSLVLLIGYRILFGNSRD"
     gene            5738..6445
                     /gene="rraA"
                     /locus_tag="B4U39_RS35225"
     CDS             5738..6445
                     /GO_function="GO:0008428 - ribonuclease inhibitor activity
                     [Evidence IEA]"
                     /GO_process="GO:0051252 - regulation of RNA metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="rraA"
                     /inference="COORDINATES: protein motif:HMM:NF006875.0"
                     /locus_tag="B4U39_RS35225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ribonuclease E activity regulator RraA"
                     /protein_id="WP_237296942.1"
                     /transl_table=11
                     /translation="MHVVRLRIGTAVRNRAPNTPDAARPPTARRVPADVRLALPAAGRP
                     GSSPRPADYPGRTTAMYEPEFEYEQRGNRYPMTVTPVPTADLYDEYGESLAICTTGFRQ
                     FGGRRLFAGPVRTVRCHEDNALLRTLLHTPGEGAVLVVDGGGSPRTALVGDLIAGAAEA
                     NGWAGLIINGSVRDSVALGGLDLGIKALGTVPRKSGKTGDGAVDEPVTIGDITFRAGDT
                     VHADDDGVVVLPR"
     misc_feature    5753..5755
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6558..8186
                     /locus_tag="B4U39_RS35230"
     CDS             6558..8186
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010040929.1"
                     /locus_tag="B4U39_RS35230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptide-N4-asparagine amidase"
                     /protein_id="WP_079407245.1"
                     /transl_table=11
                     /translation="MRRRHRITGLLGAIALTAATLAAAAPAHAAAPAADPPPTEFGTDW
                     HDPLTAAPPVTRPATRSCQVTLAEARFRDFTPYRGSYAPPTGCGADGWAKVVLRLDGKV
                     KGRQYDRLGHLSLGGVEILRTSTPQPSPDGITWAVEKDVTRYRDTLARPQPVEMLIGNV
                     VDDTYTGVIDVRVTLTFYAAEGRTRAPDTPDRVLPLTSPAVTTPRNTERLLAEVYATGS
                     GGGCEEYWYMTTPDAAPYSCKAADGPHREVRVSVDGQLAGIAAPFPTVWTGGWSNPFLW
                     YVTPGPRAFDVQPIRYDLTPYAALLNDGRPHRIEISVAGVPAGQSGWSTPTNLLLWQDE
                     AREVVTGALTRHEQSDPSGHSRWTPATPGAPHRLDTEGGHRLTVAGHLNTSHGRVATTV
                     TRTVRSTSVHRWTDGENQDALTATWTDEERVTHGPTTTRTDRAYTMDGETTLGDGDRLR
                     TVIALGDRADTVTVRGGRTVDSSRIDDRYTGDATYTANVPRDQRHAVATTSAHYRLYGS
                     GAPGGCYDRTVTTVQGTLTVDRLRC"
     gene            8214..9947
                     /locus_tag="B4U39_RS35235"
     CDS             8214..9947
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018558555.1"
                     /locus_tag="B4U39_RS35235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_237296943.1"
                     /sec_met_domain="Pkinase (E-value: 1.4e-47, bitscore:
                     161.0, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTSEAGRQLIDGRFELVAPLGSGGMGTVWRARDIALHREVALKE
                     VRPPDPATAAAQPGLTDQLRERAVREARALARLAHPHVVTIHHIVEPPEGADGHPWIVM
                     ELVQGGSLHDRLASGPMPPADVLRLGLDVLSALRAAHAEGVLHRDVKPANVLLRPSGSA
                     VLTDFGIAALHGSTGLTSTGVLIGSPEYIAPERVRGEEGLAASDLWSLGMLLYVAAEGV
                     HPLRRATSLATVVAVLDEPIPAPVRSGPLAPVLERLLVRDPAARPDGAQLEQLLRDAST
                     ALGSGYGAGVPPVLPAPPLTPAPLTPPPAAATPAGGAPAAPGQFGPYGGPYGSPTPPPY
                     GSGASPYGSSTTPVPLASVPRRRRPALIGAALTAVLAAAVVAVVQLLPDGNAGDDDAVD
                     ARATRPVVATPGGAASTPAPKASTSKAGTAARGSMLTPQNIRTALEALKEKTGTTTFVD
                     LKVYDGYVLASIPTAPGAETVDAWQYRDGSAKRTGPDGTVEEGEPLIDMSTVNWDALPG
                     LLEQSKKELGVEKPTSTYVIVEPWMMDQVPCMRPYLSDEYGRGGYVLAGIDGKVKKVVS
                     S"
     gene            10001..10906
                     /locus_tag="B4U39_RS35240"
     CDS             10001..10906
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012705.4"
                     /locus_tag="B4U39_RS35240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="squalene/phytoene synthase family protein"
                     /protein_id="WP_079407246.1"
                     /sec_met_domain="phytoene_synt (E-value: 5.6e-19, bitscore:
                     67.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 2.6e-13,
                     bitscore: 48.6, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSWRTTLTAAGVSGSRLRDDYTHAARRVLRREPAPYLALRMLAA
                     PPLVPCLAAGLAFMNLVDDVAETGTPQQRAAGLAVLSERVEAALKSGDSPDPLLRAYAH
                     AVDSRGLPPHWVSRFLAGAATAEAGFDGFEAEEDFQAYLDAYALPGVLVFTGLQYRGGP
                     DEQQAAGWRRFVDAAQRVDFLADLCGDLADGRLCIPRARLAEHGVTRTDLEQARDTPAV
                     RALLAAECRRARTALDDTRGILDLAEPGLRPVVSTMTELMAHQLTAVERAGVAALRRDI
                     GYGPAAPLRILVRAARRRPV"
     gene            complement(10925..11605)
                     /locus_tag="B4U39_RS35245"
     CDS             complement(10925..11605)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005481378.1"
                     /locus_tag="B4U39_RS35245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysM peptidoglycan-binding domain-containing
                     protein"
                     /protein_id="WP_079407247.1"
                     /transl_table=11
                     /translation="MPAKGKHRRPKHYRITRKLALAGTGGAALTLPLISATTAGAVETA
                     AAPTTYSVVAGDTLSQIAAQHSLTGGWQKLYEANRNVVGDNPSVIRPGIKLTIGTQAKT
                     AAATKTTAAAKPATAYPNNLDGWIRESLDVMAKHGIPGSYNGIHRNVMRESSGNPLAIN
                     NWDINARNGIPSKGLLQVIDPTFRAYHVPGTSQDSYDPVANITAACNYAAARYGSIDNV
                     NGPY"
     misc_feature    complement(11828..11842)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.02"
                     /tool="antismash"
     misc_feature    11847..11865
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 20.96"
                     /tool="antismash"
     gene            complement(12036..12998)
                     /locus_tag="B4U39_RS35250"
     CDS             complement(12036..12998)
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008744175.1"
                     /locus_tag="B4U39_RS35250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="WP_079407248.1"
                     /transl_table=11
                     /translation="MAQDITDIAGAAAAAAALPTRPLQGIHVPLVTPFTRTGEVAAEAL
                     EALAHEVLDAGATGIVALGTTAEAACLEEAERDLVTTVCARVCGERGAPLTVGAGASGT
                     RAAEASLARLARWPGVGAALVTVPAFVRPAAAGVLAHFARLAAASPVPLIVYHVPYRTG
                     QPLDAAALRALGSLPGVAGVKYAGGGIGEDAVALLGDLPNGFEVLAGDDLYLSPLLALG
                     AAGGILASAHLATGRFAELAGAWRAGDVARARPLGHALARMSAAAFAEPNPAVLKGVLH
                     AQGRIPTPDVRLPLLPASEGAVKAVTTALEGLDGPDGRM"
     gene            13070..14056
                     /locus_tag="B4U39_RS35255"
     CDS             13070..14056
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008748617.1"
                     /locus_tag="B4U39_RS35255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysR substrate-binding domain-containing protein"
                     /protein_id="WP_079407249.1"
                     /transl_table=11
                     /translation="MLDVRRLRLLRELARRGTIAAVGEALAFSPSAVSQQLTVLEREAG
                     LPLLERTGRRVRLTPAGQNLVRHAEAVLERLEQAEADLAEARGGLSGALRIGAFPTATR
                     AIVPAALITLARRHPGLEPMVSETDPAAVAHALRAGDLDVALVHEYDFVPAEPEPGLAT
                     EPLYGEAMYLAAPAAPDPDPAAAPDPDPAAAPDPGRPAEPEPDQGAALRTHARAPWITA
                     TPGTLCHAMTVRACQAAGFTPRIRHRVDEFATVLALVAAGQGVAVVPQLGVTGPADPAV
                     HLTRLLMQRRTKLAFRSGAGAHPAVAAFGAALRAAVPPDLAGSRAVQ"
     gene            14130..15215
                     /locus_tag="B4U39_RS35260"
     CDS             14130..15215
                     /EC_number="1.1.1.306"
                     /GO_function="GO:0050607 - mycothiol-dependent formaldehyde
                     dehydrogenase activity [Evidence IEA]"
                     /GO_process="GO:0010127 - mycothiol-dependent
                     detoxification [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (25-257). E-value: 4.2e-11.
                     Score: 34.4. Matches aSDomain:
                     nrpspksdomains_B4U39_RS35260_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267920.1"
                     /locus_tag="B4U39_RS35260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S-(hydroxymethyl)mycothiol dehydrogenase"
                     /protein_id="WP_053176657.1"
                     /sec_met_domain="ADH_N (E-value: 1.2e-27, bitscore: 94.7,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.1e-29, bitscore:
                     101.9, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHRVRGVIARSKGAPVETTTILVPDPGPGEALVRVQACGVCHTD
                     LHYREGGINDEFPFLLGHEAAGIVESVGPDVTSVAPGDFVILNWRAVCGTCRACRRGRP
                     WYCFATHNATQPMTLEDGTPLSPALGIGAFAEKTLVAAGQCTKVDPAASPAAAGLLGCG
                     VMAGLGAALNTGNVGRGDSVAVIGCGGVGNAAVAGARLAGASRIIAVDLDDRKLEWARG
                     LGATHTVNGRTDDVVKAIQGLTGGNGADVVIDAVGRPETYRQAFYARDLAGTVVLVGVP
                     TPEMKLELPLLDVFGRGGALKSSWYGDCLPERDFPLLIDLYLQGRLDLDAFVSETIPLD
                     GVEDAFARMERGEVLRSVVEF"
     aSDomain        14205..14900
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B4U39_RS35260_PKS_ER.1"
                     /evalue="4.20E-11"
                     /label="B4U39_RS35260_PKS_ER.1"
                     /locus_tag="B4U39_RS35260"
                     /protein_end="257"
                     /protein_start="25"
                     /score="34.4"
                     /tool="antismash"
                     /translation="DPGPGEALVRVQACGVCHTDLHYREGGINDEFPFLLGHEAAGIVE
                     SVGPDVTSVAPGDFVILNWRAVCGTCRACRRGRPWYCFATHNATQPMTLEDGTPLSPAL
                     GIGAFAEKTLVAAGQCTKVDPAASPAAAGLLGCGVMAGLGAALNTGNVGRGDSVAVIGC
                     GGVGNAAVAGARLAGASRIIAVDLDDRKLEWARGLGATHTVNGRTDDVVKAIQGLTGGN
                     GADVVIDAVG"
     CDS_motif       14310..14348
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B4U39_RS35260_0001"
                     /evalue="3.10E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="B4U39_RS35260"
                     /protein_end="73"
                     /protein_start="60"
                     /score="10.6"
                     /tool="antismash"
                     /translation="LGHEAAGIVESVG"
     CDS_motif       14934..14966
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B4U39_RS35260_0002"
                     /evalue="1.00E+00"
                     /label="PKSI-ER_m2"
                     /locus_tag="B4U39_RS35260"
                     /protein_end="279"
                     /protein_start="268"
                     /score="3.0"
                     /tool="antismash"
                     /translation="RDLAGTVVLVG"
     gene            15345..16649
                     /locus_tag="B4U39_RS35265"
     CDS             15345..16649
                     /NRPS_PKS="Domain: Abhydrolase_1 (48-212). E-value:
                     1.2e-16. Score: 53.0. Matches aSDomain:
                     nrpspksdomains_B4U39_RS35265_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019521295.1"
                     /locus_tag="B4U39_RS35265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_079408198.1"
                     /sec_met_domain="PF00561 (E-value: 2e-14, bitscore: 52.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAHSYRQPGTVLTDHRFSVPLDHARPDGERIELYAREVVAIGKDP
                     EALPWLLYLEGGPGFGARRFIGRQAWLERALTEYRVLLLDQRGTGRSTPVNRQTLPLRG
                     TPAQQAEYLGHFRADSIVRDAEAIRPGLTGGAPWTVLGQSFGGFCATRYLSTAPEGLTA
                     VLITGGLPSLTAGADEVYEAAYPRIERKNLAHYARYPMDVERARRIAAHLAEAPAELPG
                     GHRLTVEGFQSLGILLGGGDGSHQLHYLLEDAFVPTPAGPALSDAFLEGARSLLSFAGH
                     PLYALVHEAIYAQDPATPTAWAAERVRARHPRFDADKALAGDEPMLFTGETIHPWHFIT
                     DPALAPLRETAELLAARTGWQPLYDPARLAANDVPVAAAVYHDDMYVDTAHSLETARSV
                     RGLRTWVTDEFEHDGLRAGGTRVLDRLLSLVRDGA"
     aSDomain        15489..15980
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B4U39_RS35265_Abhydrolase_1.1"
                     /evalue="1.20E-16"
                     /label="B4U39_RS35265_Abhydrolase_1.1"
                     /locus_tag="B4U39_RS35265"
                     /protein_end="212"
                     /protein_start="48"
                     /score="53.0"
                     /tool="antismash"
                     /translation="PWLLYLEGGPGFGARRFIGRQAWLERALTEYRVLLLDQRGTGRST
                     PVNRQTLPLRGTPAQQAEYLGHFRADSIVRDAEAIRPGLTGGAPWTVLGQSFGGFCATR
                     YLSTAPEGLTAVLITGGLPSLTAGADEVYEAAYPRIERKNLAHYARYPMDVERARRIAA
                     H"
     misc_feature    complement(16660..16673)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.15"
                     /tool="antismash"
     gene            16791..18533
                     /locus_tag="B4U39_RS35270"
     CDS             16791..18533
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033679.1"
                     /locus_tag="B4U39_RS35270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DNRLRE domain-containing protein"
                     /protein_id="WP_079407251.1"
                     /transl_table=11
                     /translation="MSSAVSLALAGGLAVAGVVAGPATAAVAAPAVSAAGAGETPVGAQ
                     AWTRVSKKYPNRSYWNAAGDLRVGNEAGTEGLSRAYLRLDTTALAGATVSKATFRITNT
                     GAASCTGRPVELWSVGAVSAKTTWNNQPAKAVRLATVTDAKGREGCAAGDLEFDATALV
                     KEAAATSQASVTVGLFAANESDASAWKRFAPATAKLETTIGRPAPPVISSPEFPDASNG
                     APADTGKARTPGTFTFGTGGATNIEKIVYWSDFDPREVTVAPGGSAVITPTGSGPHSIH
                     AYSVDRAGRRSDQAMYQFWALGNGGVRDAAGDLNGDGLRDLWTLDPAGRLRFSAGRADG
                     TFAAPVDAGASFAPGSRIAAGGDWGEDGYNDLLVLEFAEGLGAKQLRVLPNNGLGSVRP
                     HDGIVLSVLEDDPAQGNDHWSDAQDIADAGDLNGDGEPDLLVEQGAKLWAYTGSRSGYL
                     DMNGAPVLVGDGGWDTVSVLAPGDTDGDGAGDLWVRDDASGDLFAVKGAKDAAGQLDPR
                     SWGTAQRVKIGSGLGRTACPTLAAAADFDRDGLVDLAAVGADGKAVWFRATATGIDATP
                     RPIG"
     gene            complement(18567..19385)
                     /locus_tag="B4U39_RS35275"
     CDS             complement(18567..19385)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019891127.1"
                     /locus_tag="B4U39_RS35275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_079407252.1"
                     /transl_table=11
                     /translation="MDRQGRVVALLDATGIFFEPAHAAFPGAGEAAWARAAELDPGAFG
                     PDGAWALDFRCFAIARPGGRWVLVDAGVGPARSPAAAWAPVPGRLPDALAVAGIAPADV
                     EAVVLTHLHEDHAGWSSGDDGEPFFPEARYVVQRAEVAALDRADPVWDWTVAPLRARGR
                     LHEVDGVHRLVPGVTLLPTPGHTPGHQSVLVDQGDGARDVVVTGDVLVHAVQLGDPAVP
                     YSHERDRDTARTSRRALLDRARERGALLATAHLTRAFIEPPPETTAGRRP"
     gene            19404..20165
                     /locus_tag="B4U39_RS35280"
     CDS             19404..20165
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PIG-L"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018523247.1"
                     /locus_tag="B4U39_RS35280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PIG-L deacetylase family protein"
                     /protein_id="WP_030390525.1"
                     /sec_met_domain="PIG-L (E-value: 1.7e-24, bitscore: 85.7,
                     seeds: 137, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEQPDQQDTLQPMPTDWTRALAVVAHPDDLEYGCAAAVADWTDG
                     GREVVYLLATRGEAGIDSIAPADCGPLREAEQRASAAVVGVSEVEFLDYHDGVIEYGLG
                     LRRDIAAAIRRHRPELLVTLNHRDTWGGAQGGGYWNTPDHKAVGRAVLDAAGDAGNRWI
                     FPELIEQGLQPWDGVRWVAVAGSSTPTHAADAGPGLERSVKSLMEHKAYIEVLTDQDPE
                     EYVRTFLTGNAQQAAARFGGRPAVPFEVFPR"
     misc_feature    20820..20835
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.75"
                     /tool="antismash"
ORIGIN
        1 gcagtgaaga tcctcatcgt gaccggcgac gcggccgagt cgctggaggt cctgtatccg
       61 taccagcgcc tgcgcgagga ggggtacgag gtccacatcg cggcgccgca ggtgaagaaa
      121 ctgcggttcg tggtgcacga cttcgaggac gggttcgaca cctacaccga gaagcccggc
      181 tacacctggc ccgccgatct ggccttcgtg gacgtggtca ccgaggacta cgatgccctg
      241 gtcgtcccgg gcggccgggc accggagtac ctgcgcaacg acccggaggt gcgccggatc
      301 ctggccgcct tcgcggaggc cgacaagccg atcgcccaga tctgccacgg gccgctgatc
      361 accgccgcgg ccggcgggct gaccggccgc cgggtgaccg cgtatcccgc gctcgaactg
      421 gacatgaagg cggccggcgc cgagttcgag gactccgaga ccgtggtcga cggcacgctg
      481 gtctcggcca gggcctggcc cgaccactcg agctggatgc gggagttcct gaccgtgctg
      541 cggagcaagg ccccggtggt ctgagcggca tcgcaccgac ggccgtgacc ccctgcgcca
      601 gggggtcacg gccgtcgggt cgtgcggggc ggaggacgat ttcaagccgg tcgggagacc
      661 ggctcccccc gacctcggtg atcgtcagcc gacgggggtg atcggcggcg ccggctcgta
      721 cttgtagttc gcaccgaagt tcttcttcac ggccgtctcc caggagccgt ccgcgaccat
      781 cttcttcagc gcgtcgttga tcttgcgctg gagctccttg ttgcccttct tgacgccgat
      841 gccgtagttc tcgttgctca ggttctggcc gagcagcttg aacttgttct cgttgccctt
      901 gcgcgcggcg tagccggcca ggatggcgtt gtccgtggtc atggcgtcga cccggctgtc
      961 ctggagtgcg acgacgcagt ccgagtagcc gccgagctcc agcaggccgg ccttgggggc
     1021 gaggttcttg cggaggttct cggccgaggt ggagccggtg acggagcaca ggctcttcga
     1081 gttgaggtcc tcgggcttgt tgatcgaggc gtcgtcggca cgcgtcagca ggtcctggtg
     1141 cgcgacgaag tacgggccgg cgaaatcgac cttctccttg cgcttctcgt ttatcgagta
     1201 gctcgcgacg acgaacttga cctcgttgta ctggatcagc agttcgcggt cgttgctgta
     1261 gacctgcttg aattcgatct tgtcggcctt gtagccgagc tccttggcca cataggtggc
     1321 gacatccacg tcgaaaccgg tgaacgtgcc gtcgacctcc cgcattccga tgccgggctg
     1381 gtcgaacttg atgccgatgg cgagggttcc gtccccctgg tccccgtcgt caccgatgca
     1441 cccggaggcg gtcagtgcga tcgcgatcac tgcggcgacc gcaccggcct ggggaacctt
     1501 catgctgcac tctttcctga ggaacgcggg gcgcgtcacc gggatcgccg ggggcgtgtg
     1561 gaaccgcgcg aaaacgggga acgtcggaac gcgtgtacga ggaagctagg aagcggacgg
     1621 gcgcagcgtc actacatttg aggaaaactt gaggataaca atccggttct gtggcgcatt
     1681 ctgcggctga cctggggcgg agcgggaaaa aggggggcgg gtcctcttgt tcgcccctca
     1741 cgcctgcccg aattcggtac tcgtatattt gcacccggtt tgggtgatat cccctgcggc
     1801 ggcccattgg gtcgaatcgg ctggtttcgc cgaatcggcc agtcctgccg aactggccgg
     1861 gaaagaacgg tcgtccggag cgggccgggg gctcgtggga tcatggacgg gcaatgcccg
     1921 tgaacgaagg gggagttcgg tgaccggtgt acgcaagggc ctggccaagg tggagttcgc
     1981 gctgcggtgg gaccccagcc cggccggcgc gcccgcgaac gacctcgaca tagtcgccgg
     2041 ggtctacggc gccgcggacc cgcacgggac ccccgtccag ctcgtgcact tcggaagccg
     2101 gtcgcccgac gggaccatcg cgctgaaccg ggacagccac accggtcagg gcttcggctt
     2161 cgacgaggtg atgaccatcg agctgaaccg gatggcgccg gaggcgggcc gggtggtggt
     2221 cggcgtggtc atccagaact ccgacgcggg ccccgagggc cgtacgaaga ccttcgccga
     2281 catcgccggt accggattcc ggatccgcga gggccacacg gacctcgcgg agggggactt
     2341 cgcggccgtg gccgccgcga ccgccgccac cgtcgccgag ttcacccgtg acgcgtccgg
     2401 cgcctggagc ttcgacctgt gggtgcgggg ctccgacgcg gacccggagg aattcgcccg
     2461 gaccatgggc gccctccgct gaggtcgccc tctgtcgagg tgtcactccg ctgaggtgtc
     2521 actccgctga ggccgcgctc cgctgaggcc gcgctccgct gaggcggcgc tccgccgggc
     2581 cgcatggatc gggaggccgc acagatcggg cggcgaccac tcctggggtg agtggtcgcc
     2641 gcccgatccg ggtggcgcgc tgccgccgtc cccacgaggc agcgcgggcg ggtcgccgtc
     2701 aggtcatcag gacggcggcc cgccggttca gggggcccgc tcggccgggg gccgggcggg
     2761 gtgggagggc acgaggccca gggacgggag catgacggcg tcgacgaacc ggaccaggta
     2821 gtcggcgtcc gcgtaccgcc cctccagcac cggccggatc cggagcacgc ccatcagctg
     2881 ggcgggcagg aactccaccg ccgggtggtc cgcggcgatc tcgccgcgcg ccacagcccg
     2941 tccgaccatc tcggcgaagg cggccagctc cggttcgacc agcgcctcgc gcagggcggc
     3001 ctggagttcc tcgtcgctga gcacggcatg cccgagggcc tgtgtcagcc gggtgtccct
     3061 gccggaggtg ccggccgcga tccgggcggc ttcgcgcaga tcgcccgcca gcgagcccgt
     3121 gtccacggcg acgagcgtgc cccgtcggcc cgcgcgcagg gcggcggcga cgagctgggg
     3181 cttggtcttc cactgccggt agagcgtgga tttgccgcag ctggcccggg cggcgacgcc
     3241 ctccatggtc agggcctcgt agccgtgctc gcgcagctgc tccagtacgg cgtcgtagaa
     3301 ctcctgctca cgctccgggg tgatcttgga gcggcgcgcg ggggtcggtg gcgacgtcat
     3361 ggatgcggct ctcctcgggg gcgcctcggc ggcaggttcc actacggaag tgtacgggaa
     3421 cgcaaccgta tcggtacacc agcgtatcga tacgccaatg tatcgataca ctggcgtgtc
     3481 gctgtgcgcg ttaacaggaa gagagaccgg gggatgagct cccacaccac acctgccgag
     3541 ccggcagccg caccgagagc cgcgcgccgc cgcctcatac gcgagctgct gctcgtcgcg
     3601 ggcttcttcg ccgtctacaa ggcgggtcgg ctgctctcga ccgaccgcac cgaagaggcc
     3661 ttccgcaacg ccgggcgaat atgggacgcc gagcgcgccc tgcacctacc gggcgaaggc
     3721 ctcctgcagc ggttgctgct ccacggggac gccctcgtca ccaccgcgaa cacgtactac
     3781 gcgggagtcc acttccccgc gaccgcgctc ttcctgatct ggctctacgt gcgccgaccc
     3841 gcccactacc tgtggacgcg ccgggtcctc gccgcactca ccgcagccgc cctcgccctg
     3901 cacctggcct acccgctcgc gcccccgcgc ctgctcgacg ccgcgcagct catcgacacg
     3961 gcgcaggtct acgggcccag cgtctaccgg gccgcaccgg ccgaggacac cctggccaac
     4021 cagttcgccg cgatgccctc cctgcacttc ggctgggcgc tgatgctcgc cgtcggcgtg
     4081 atcgccgcca cctcctcgcg gtggcgcttc ctgtggctgc tgcacccgct gctgaccctg
     4141 atcgtcatcg tcggcaccgc caaccactac tggctcgacg ccgtcgtggc cgccgtcctc
     4201 ctcggagcgg ccctgctgct ggtcccgaag ccgcgcgcga acgacgaacc cgacgacgaa
     4261 cccggcgacg acgcggacgc cgccgggccc gatcccgggg cgacccacga gaacgacccg
     4321 gacgggtccg tacgaggcct gccgcgcccg aggagcgcgg acgcggccgt aggagcagga
     4381 caatgaacga caccaccctc gccgtcgggc tctgcctcgc ctcggccgtg gcctacgcgg
     4441 ccggcgccgt cgcccaggaa cggctcgcac gggccgcggt cgcacgcacc gccggggccc
     4501 tgatgggctc cggcgcctgg tggtggtcgg ccggcctgaa cgccgccgcc gccctgctgc
     4561 acgcggcggc cctgcggtac ggccccctca ccctggtgca gccgctcggc gcgctcaccc
     4621 tggtcgccgc cgtcccgctg ggcgcgcgca ggtccggccg ccgggtggtg gccaccgaat
     4681 ggcggggcac cctggccacc gtcgccgggc tcggcctgct gctgctcccg gcctccgggc
     4741 cggcccccga cgacacgctc accctgatcg aggcgctggc cgtctccggc gcgaccatcg
     4801 ccgtgatcat gatgctgacc gcggtcaagg accctcgctc gggtctgcgc cacgccaccg
     4861 cgtccggcct ggcctccgcg gccgcctccg ccctgaccca gacggtggcc gtggcggccg
     4921 ggcgcggcgg agcactgctc agcgtccggg tcgtctccgt ggccctgctg gtcgtggtgt
     4981 tcgcggtcgg cgggatgctg ctgtcgcagc gggcctaccg cggcggactc ggcgccccgc
     5041 tcgccgtggt gaacctggcc aacccgctgg ccgcggccgt catcggcatg gtcctgctcg
     5101 gcgaacggct gcagggcgga ctggcggggg tgctgctggc ggccaccgga gccctgctcg
     5161 cggcgcgcgg agtggtcctg ctcacccgga cgccctccgc cccggcgggt ccgggcgccg
     5221 gcgccgtcac gagtgccgtc gcggccgccg agctgcccgt accggtcggc cgcgtggccg
     5281 tctgagcagc agagaaccgt ttcggcccag gtcgcgtcct ccgaggagta cgactgaacg
     5341 actgaacgac cggacgaccg aagcggagtg actggacatg gggatcgtca gctggatcat
     5401 cctgggactg ctggccggag gtatcgccaa ggtcctgctg cccggccggg accccggcgg
     5461 cctgatcggc accaccctga tcggtgtcgc cggagccttc atcggcggct ggctctcggc
     5521 aaaggtcctg gacaagccga tccagaccga gttcttcgac ctcgccacct ggggctccgc
     5581 catcgcgggc tcgctggtcc tgctgatcgg ttaccgcatc ctcttcggca actcccgcga
     5641 ctgacccggt ccggcgggcc ccgccggggc catcttgccg ccgccgtgtt cctgtacgcc
     5701 ctccacgggt tgcccggcag gcaactcggg tccgcgcgtg cacgtcgtgc gcttacggat
     5761 cggcaccgcc gtccggaacc gggcccccaa tacgcccgac gccgcccggc ccccgaccgc
     5821 ccgtcgggtt ccggccgatg tccggctcgc acttcccgct gccggccgcc ccggcagctc
     5881 cccgcgaccg gccgactacc ctggccgcac caccgcgatg tacgagcccg agttcgagta
     5941 cgagcagcga ggaaaccggt acccgatgac cgtcaccccc gtccccaccg ccgacctgta
     6001 cgacgagtac ggcgagtccc tcgccatctg caccaccggg ttccgccagt tcggcggccg
     6061 ccggctcttc gcggggcccg tacggaccgt ccgctgccac gaggacaacg cgctgctgcg
     6121 caccctcctg cacacaccgg gcgagggcgc ggtcctcgtc gtggacggcg gcggctcgcc
     6181 gcgcaccgcc ctcgtcggcg acctcatcgc gggcgcggcc gaggccaacg gctgggccgg
     6241 actgatcatc aacggttcgg tccgcgacag cgtcgccctc ggcgggctcg acctcggcat
     6301 caaggcgctg ggcacggtcc cccgcaagag cggcaagacc ggcgacggcg cggtcgacga
     6361 gcccgtcacc atcggcgaca tcaccttccg cgcgggcgac accgtccacg cggacgacga
     6421 cggcgtggtc gtcctgccgc gctgatccgc ctcccccggc gtaccggcgt accggcggac
     6481 cgggcggatc agaaccggcc agggccgaag tcccggccct ggcacggccg tcgcgggccg
     6541 ggtttcactg cgggtccatg agacgacgac accggatcac cggcctgctc ggcgccatcg
     6601 cgctgaccgc cgccaccctg gccgccgcgg cacccgcgca cgcggcggcc ccggccgccg
     6661 acccgccgcc cacggagttc gggaccgact ggcacgaccc cctcaccgcg gccccgcccg
     6721 tcacccgccc cgcgacccgc tcctgccaag taaccctcgc ggaagcccgg ttccgtgact
     6781 tcacccccta ccggggcagt tacgcaccgc ccaccggttg cggcgccgac ggctgggcca
     6841 aagtggtcct gcgcctggac ggcaaggtca agggccgcca gtacgaccgc ctcggccacc
     6901 tctccctcgg cggggtcgag atcctgcgca cctcaacccc gcagccctcg cccgacggca
     6961 tcacctgggc cgtcgagaag gacgtcaccc gctaccgcga caccctcgcc cgcccgcagc
     7021 ccgtcgaaat gctcatcggc aacgtcgtcg acgacaccta caccggcgtc atcgacgtcc
     7081 gggtgaccct caccttctac gctgccgaag gccgcacccg ggcccccgac acccccgacc
     7141 gcgtcctgcc cctcacctcc ccggcggtca ccacccctcg caacacggag cgcctgctcg
     7201 ccgaggtgta cgccaccggc tcgggcggcg gctgcgagga gtactggtac atgaccaccc
     7261 ccgacgcggc cccgtactcc tgcaaggccg ccgacggccc ccaccgcgag gtccgcgtct
     7321 ccgtcgacgg acaactcgcg ggcatcgccg cgcccttccc caccgtctgg accggcggct
     7381 ggtccaaccc cttcctctgg tacgtcaccc cgggcccgcg cgccttcgac gtccagccga
     7441 tccgctacga cctcaccccc tacgccgccc tcctcaacga cggccgcccg caccggatcg
     7501 agatctcggt cgccggggtg ccggccggac agagcggctg gagcacaccc accaatctgc
     7561 tgctctggca ggacgaggcc cgggaggtcg tcaccggcgc cctgacccgg cacgagcaga
     7621 gcgatccgag cggccactcc cgctggacac ccgcgacgcc cggcgcaccg caccggctgg
     7681 acaccgaggg cggacaccgg ctgaccgtcg ccggacacct gaacacctcc cacggccggg
     7741 tggccaccac cgttacccgc accgtgcgga gcacctccgt gcaccgctgg accgacggcg
     7801 agaaccagga cgcgctcacc gccacctgga ccgacgagga gcgcgtgacg cacgggccga
     7861 ccaccacccg gaccgaccgc gcctacacga tggacggcga gaccaccctc ggggacggcg
     7921 accggctgcg caccgtcatc gccctcggcg accgcgcgga caccgtcacc gtgcgcggcg
     7981 gacgcaccgt cgacagctcc cggatcgacg accggtacac gggcgacgcc acctacaccg
     8041 cgaacgtccc gcgcgaccag cggcacgcgg tcgcgaccac ctccgcccac taccgcctgt
     8101 acgggtccgg agcgccaggt gggtgttacg accgcacggt gaccaccgtc cagggaacgc
     8161 tgacggtgga ccgcctgcgc tgctgatccc gccgccccct acgatgagcg gccatggata
     8221 cgagtgaggc cggcagacag ctgatcgacg gccgtttcga gctggtcgca cccctgggca
     8281 gcgggggcat gggtacggtg tggcgcgccc gcgacatcgc cctgcaccgc gaggtcgcac
     8341 tcaaggaggt gcgcccgccg gacccggcga ccgccgccgc ccaacccggc ctcaccgacc
     8401 agctgcgcga acgggccgtc cgcgaggccc gcgccctcgc ccgcctcgcc cacccgcacg
     8461 tggtgaccat ccaccacatc gtcgaaccgc ccgagggcgc ggacggacac ccgtggatcg
     8521 tcatggagct ggtgcagggc ggctccctgc acgaccggct ggcgtccggg ccgatgcctc
     8581 ccgcggacgt actgcggctc ggcctcgacg tgctctccgc gctgcgcgcc gcgcacgccg
     8641 aaggggtgct ccaccgcgac gtgaagccgg ccaacgtgct gctgcgcccc agcgggtcgg
     8701 cggtgctcac cgacttcggc atcgcggccc tgcacggatc gaccgggctc acctcgaccg
     8761 gcgtactgat cggctcgccc gagtacatcg cgcccgaacg cgtccgcggg gaggaagggc
     8821 tggccgcctc cgacctgtgg tcgctgggca tgctgctcta cgtggccgcg gagggcgtcc
     8881 atccgctgcg ccgggccacc agcctggcca ccgtcgtcgc cgtgctcgac gaaccgatcc
     8941 cggcgcccgt gcgctccggc ccgctggcgc ccgtactgga acggctgctc gtacgggacc
     9001 cggcggcgcg gcccgacggg gcgcagctgg aacaactgct ccgcgacgcg agcaccgctc
     9061 tcggatccgg ctacggggca ggtgtgcccc cggtccttcc cgcaccgccg ctcaccccgg
     9121 cgccgctcac cccgccgccc gccgcggcca cgccggccgg cggcgcgccg gccgcccccg
     9181 gccagttcgg cccgtacggc ggcccctacg gatcgccgac cccgccgccg tacggctccg
     9241 gtgcctcccc ctacgggtcc agcaccacac ccgtcccgct ggcgtccgtc ccgcgccggc
     9301 gccgcccggc cctgatcggc gccgcgctca cggcggtgct cgcggccgcc gtcgtcgccg
     9361 tcgtccagtt gctgcccgac gggaacgccg gcgacgacga cgccgtcgac gcgcgcgcca
     9421 cccggcccgt cgtcgccacc ccgggaggcg ccgcctcgac cccggccccg aaggcgagca
     9481 cgtccaaggc cgggacggcg gcccgcggca gcatgctcac cccgcagaac atccggaccg
     9541 ccctggaggc gctcaaggag aagaccggca ccacgacctt cgtggacctc aaggtctacg
     9601 acgggtacgt gctcgcctcg atccccaccg cccccggtgc cgagaccgtc gacgcctggc
     9661 agtaccggga cggctcggcc aagcgcaccg gaccggacgg cacggtcgag gagggcgagc
     9721 cgctgatcga catgtcgacc gtcaactggg acgcgctgcc cggcctgctg gagcagtcca
     9781 agaaggagct gggcgtcgag aagccgacct cgacctatgt gatcgtcgag ccgtggatga
     9841 tggaccaggt cccctgcatg cgcccctacc tcagcgacga gtacggccgc ggcggctacg
     9901 tgctcgccgg catcgacggc aaggtcaaga aggtcgtcag ctcctgacat cctgtagccg
     9961 tacgcacgta cggtccgaca ggtcagggag cacgaccacc atgcccagct ggcgcaccac
    10021 cctcacggcg gccggtgtgt ccggctcccg gctgcgggac gactacacgc acgccgcccg
    10081 ccgggtgctc cgccgcgagc cggccccgta cctggcgctg cggatgctcg ccgcgccgcc
    10141 gctggtgccc tgcctcgccg cggggctcgc cttcatgaac ctcgtcgacg acgtcgccga
    10201 gaccggtacc ccgcagcaac gggccgccgg cctcgccgtg ttgtccgagc gggtggaggc
    10261 ggccctgaag tccggggaca gccccgaccc gctgctgcgg gcctacgcgc acgcggtgga
    10321 ctcccgcggt ctgccgccgc actgggtctc ccgcttcctg gcgggcgccg ccaccgccga
    10381 ggccggattc gacggcttcg aggcggagga ggacttccag gcctacctcg acgcgtacgc
    10441 gctgccgggg gtgctggtct tcaccgggct ccagtaccgg ggcggccccg acgagcaaca
    10501 ggcggcgggc tggcggcggt tcgtcgacgc cgcccagcgc gtggacttcc tcgccgacct
    10561 ctgcggggac ctcgcggacg gccggctctg catcccccgc gcccgtctcg ccgaacacgg
    10621 ggtgacccgc accgacctgg aacaggcccg cgacaccccg gccgtacggg ccctcctcgc
    10681 cgccgagtgc cggcgtgccc gtacggctct ggacgacacc cgcggcattc tcgacctcgc
    10741 cgagcccgga ctgcgtcccg tggtctcgac catgacggag ctgatggcgc accagctcac
    10801 tgccgtggag cgcgcggggg tcgccgccct gcgccgggac atcgggtacg gcccggcggc
    10861 gcccctgcgg atcctcgtcc gcgccgcccg gcgtcgcccg gtgtgaaccg gtgcagggag
    10921 tttcctagta gggcccgttg acgttgtcga tcgagccgta gcgcgcggcc gcgtagttgc
    10981 aggcggcggt gatgttggcg accgggtcgt aggagtcctg cgaggtgccg ggcacgtggt
    11041 aggcgcggaa ggtggggtcg atgacctgga gcaggccctt ggacgggatg ccgttccggg
    11101 cgttgatgtc ccagttgttg atcgccagcg ggttgccgga ggactcgcgc atcacgttgc
    11161 ggtgaattcc gttgtaggag ccgggaatac catgcttcgc catgacgtcg agggactcgc
    11221 ggatccaccc gtcgagattg ttcgggtagg cggtggcggg cttggcggcg gcagtggtct
    11281 tggtcgccgc ggccgtcttc gcctgggtgc cgatggtcag cttgatgccg ggccggatga
    11341 ccgacgggtt gtcacccacg acgttccggt tcgcctcgta gagcttctgc cagccgccgg
    11401 tgagggaatg ctgcgccgcg atctgcgaaa gggtgtcgcc cgcgacgacg gaataggtcg
    11461 tgggggcggc ggccgtctcc accgcgccgg cggtggtcgc gctgatcagc gggagagtga
    11521 gggccgcgcc acctgtgccg gcgagggcca gcttgcgggt gatccggtag tgcttcggcc
    11581 gacggtgctt accctttgca ggcatggcgg aattcctcac gtggggggac gggagatccc
    11641 gggcgggggc cgtattcggc agctgaccac caggaacgag gtgaccgtag gcgagcgcgc
    11701 cgcgccggaa caagccccga attccaccga tagatcgaca tctcgctttc ggtcgggtaa
    11761 atgaccttga aggcgtcatg gcgcaatagt cgattccctt tccgggaaaa gggaatcggc
    11821 tattcgcggg aaatgatgtt gaagtgtcgg gtgtggctca catcacggtt tacgggccgg
    11881 gtggccaatt cgggcaagtc cgctgtccgg gtgtctcatt cgggcgagcg gcccgtaggt
    11941 ggcgaatcgc ccatggggga ctctttccgg cggattgtcg gtcgctgcgc cgcctgcttg
    12001 cgtccgattc ggcgccgccc tgtcggcccc tcgggtcaca tccgcccgtc cggcccgtcc
    12061 agcccctcca gcgcggtcgt caccgccttc accgccccct ccgaggccgg cagcaggggc
    12121 agccggacgt ccggcgtcgg gatccgcccc tgcgcgtgca ggacgccctt gagcaccgcc
    12181 ggattcggct cggcgaacgc ggccgccgac atccgggcca gcgcgtgccc cagcggccgc
    12241 gcccgcgcca cgtcaccggc ccgccaggcg ccggcgagct cggcgaaccg gcccgtcgcc
    12301 agatgcgccg aggccaggat cccgcccgcc gcacccagcg ccagcagcgg cgacaggtac
    12361 aggtcgtcac ccgccagcac ctcgaacccg ttcggcaggt caccgagcag tgccaccgcg
    12421 tcctcgccga tgccgccgcc cgcgtacttc accccggcga cccccggcag cgatccgagc
    12481 gcccgcagcg cggccgcgtc cagcggctgc ccggtgcggt acgggacgtg atagacgatc
    12541 agcgggacgg ggctcgcagc ggccagccgc gcgaagtgcg ccagcacacc ggcggccgcc
    12601 ggcctgacga aggccggcac cgtcaccagc gccgccccca ccccgggcca ccgggccagc
    12661 cgggccagcg aggcctcggc ggcccgggtg ccgctcgccc ccgcacccac ggtcagcggc
    12721 gcgccccgct ccccgcagac ccgggcgcac accgtggtga cgaggtcgcg ctccgcctcc
    12781 tcgaggcagg ccgcctccgc ggtggtgccg agcgcgacga tcccggtggc gcccgcgtcg
    12841 agcacctcgt gggccagcgc ctccagtgcc tcggcggcga cctccccggt gcgggtgaag
    12901 ggcgtgacga gcggtacgtg gatcccctgc aacggccggg tcgggagggc cgctgccgct
    12961 gccgctgctc ctgcgatgtc tgtgatgtcc tgtgccatac cgacgagcct cgcccgcgga
    13021 aaggatcaaa tccagttcgc gtttcttacc cgaaccgtaa gctgatccga tgctcgacgt
    13081 acgacgcctg cgcctgctgc gcgaactggc ccgccgcggc accatcgccg ccgtcggcga
    13141 ggccctcgcc ttcagccctt cggcggtctc ccagcaactc accgtcctcg aacgcgaagc
    13201 cggcctgccg ctgctcgagc gcaccggccg ccgggtccgg ctcaccccgg cgggccagaa
    13261 cctggtccgg cacgccgagg ccgtcctcga acgcctcgaa caggccgagg ccgacctcgc
    13321 cgaggcgcgc ggcgggctct ccggagcgct gcggatcggc gccttcccca ccgcgacccg
    13381 ggccatcgtc ccggccgccc tgatcaccct cgcccggcgc cacccggggc tggagccgat
    13441 ggtctcggag accgacccgg ccgcggtggc gcacgccctg cgggccgggg acctggacgt
    13501 ggcgctggtg cacgagtacg acttcgtacc cgccgagccc gagccgggac tggccacaga
    13561 accgctctac ggcgaggcga tgtacctggc cgcgcccgcc gccccggacc ccgacccggc
    13621 cgccgccccg gaccccgacc cggccgccgc cccggacccc ggccggcccg ccgagccgga
    13681 acccgaccag ggcgcggccc tgcggacgca cgcccgggcc ccctggatca ccgccactcc
    13741 cggcaccctc tgccacgcca tgaccgtccg ggcctgccag gccgccggct tcaccccgcg
    13801 catccgccac cgggtcgacg agttcgccac cgtgctcgcg ctggtcgcgg cgggccaggg
    13861 cgtggccgtc gtaccgcagc tcggagtcac cggccccgcc gatccggccg tacacctcac
    13921 gcgcctgctc atgcagcgcc gcaccaagct cgccttccgc agcggggccg gcgcccaccc
    13981 cgccgtggcg gccttcggcg ccgcacttcg ggccgccgta ccgccggatc tggccgggtc
    14041 gcgcgccgtg cagtgacaca actcccgtac cgcgtgccgt ccgtgtacgt tcggcgatcc
    14101 agaccgattc gatcagagcg gggtacgacg tgacgcatcg cgtacgaggg gtcatcgccc
    14161 ggagcaaggg cgcaccggtg gagacgacga cgatcctcgt gcccgacccg ggacccggcg
    14221 aggcactcgt ccgggtgcag gcctgcgggg tctgccacac cgacctgcac taccgcgagg
    14281 gcggcatcaa cgacgagttc cccttcctgc tcggccacga ggccgccgga atcgtcgagt
    14341 ccgtcggccc ggacgtcacc tccgtggctc ccggtgactt cgtgatcctc aactggcgcg
    14401 cggtgtgcgg cacctgtcgc gcctgccgac gcggccgccc ctggtactgc ttcgccacgc
    14461 acaacgccac ccagcccatg accctggagg acggcacccc gctctccccg gccctgggga
    14521 tcggtgcgtt cgccgagaag accctggtcg cggccggcca gtgcaccaag gtcgacccgg
    14581 cggcctcccc ggccgccgcc ggcctcctcg gctgcggggt gatggccggc ctcggcgccg
    14641 ccctcaacac cggcaacgtc gggcggggcg attccgtcgc cgtcatcggc tgcgggggag
    14701 tgggcaacgc ggccgtggcc ggagcccgcc tggcgggcgc ctcgcggatc atcgccgtgg
    14761 acctggacga ccggaagctg gaatgggcgc ggggcctggg cgccacgcac accgtcaacg
    14821 gacggaccga cgacgtggtc aaggccatcc agggcctgac cgggggcaac ggcgcggacg
    14881 tggtcatcga cgccgtgggc cgccccgaga cctaccgtca ggccttctac gcgcgcgacc
    14941 tcgccgggac ggtggtcctg gtgggcgtgc cgacaccgga gatgaagctc gaactcccgc
    15001 tcctcgacgt cttcggccgc ggcggcgccc tgaagtcctc ctggtacggc gactgcctgc
    15061 ccgagcgcga tttccccctg ctgatcgacc tctacctcca gggccggctc gacctggacg
    15121 ccttcgtctc cgagaccatc ccgctcgacg gcgtcgagga cgccttcgcg cggatggaac
    15181 gcggtgaggt actccgctcg gtcgtcgagt tctgacaccc cgtccggccc gccgcggccg
    15241 gacccggccc gcctagaatc gggccaccac ccccgcgccc ccgccgccac ccggccgggg
    15301 cgcggtcctt catcacctcg tacccctggg ggccgtccgt gaccatcgca cacagctacc
    15361 gccagcccgg cacggtcctc accgaccacc ggttctccgt ccccctggac cacgcgcgcc
    15421 cggacgggga gcggatcgag ctgtacgccc gcgaggtcgt ggccataggc aaggaccccg
    15481 aggcgctgcc gtggctgctc tacctggagg gcggtccggg cttcggggcc cgccgtttca
    15541 tcggccgcca ggcctggctg gagcgcgcgc tgaccgagta ccgggtgctg ctgctcgacc
    15601 agcgcggaac gggccgctcc accccggtga accggcagac cctgcccctg cggggcaccc
    15661 ccgcccagca ggccgagtac ctcggccact tccgcgccga ctccatcgtg cgcgacgccg
    15721 aggccatccg gcccggcctg accggcggcg cgccctggac cgtgctcggc cagagcttcg
    15781 gcggcttctg cgcgacccgc tacctctcca ccgcgcccga aggcctcacc gccgtcctca
    15841 tcaccggcgg cctgccgtcc ctgaccgccg gcgccgacga ggtgtacgag gccgcgtacc
    15901 cccgtatcga gcgcaagaac ctggcccact acgcccgcta cccgatggac gtcgaacgcg
    15961 cccgccggat cgccgcccac ctggccgagg cgccggccga actccccggc ggccaccgcc
    16021 tcaccgtcga gggcttccag tccctcggca tcctcctcgg cgggggcgac ggcagccacc
    16081 agctccacta cctgctcgag gacgccttcg tcccgacccc cgcgggaccc gccctctccg
    16141 acgccttcct ggaaggcgcc cgctccctgc tgtccttcgc cgggcacccc ctctacgcac
    16201 tggtccacga ggcgatctac gcccaggacc ccgccacgcc caccgcctgg gccgccgaac
    16261 gcgtgcgtgc ccgccacccc cgcttcgacg cggacaaggc tctcgcgggc gacgagccga
    16321 tgctcttcac cggcgagacc atccacccct ggcacttcat caccgacccg gccctcgccc
    16381 ctctgcgcga gaccgccgag ctcctggccg cccgcaccgg ctggcagccg ctctacgacc
    16441 cggcccgact ggccgccaac gacgtgccgg tggcagccgc ggtctaccac gacgacatgt
    16501 acgtggacac ggcgcactcg ctggagacgg cccgctccgt ccggggcctg cggacctggg
    16561 tgacggacga gttcgagcac gacggcctcc gtgccggcgg cacccgcgtc ctggaccgcc
    16621 tgctgtccct cgtccgcgac ggggcgtaac cggggtcggt gcgtgtccgt gcaggtcagg
    16681 ggtgtgatgg aggccccgat taatcgttcc cgcagaagtt gatcacacgg ttagggtggg
    16741 cgctcgtacc tgagaaccga ccgatgtgtg gagcgtgcat gctgagaagg atgtcgagcg
    16801 ccgtctcgct ggccctggcc ggcggactgg ccgtggccgg cgtggtggca gggccggcga
    16861 cggccgccgt cgccgcgccg gccgtcagcg ccgcgggggc gggggagacc cccgtcggcg
    16921 cgcaggcctg gacgcgcgtg tccaagaagt acccgaaccg ctcctactgg aacgccgccg
    16981 gcgacctgcg cgtcggcaac gaggccggca ccgaggggtt gtcccgcgcg tacctccgcc
    17041 tggacaccac cgcgttggcg ggtgccacgg tctccaaggc gaccttccgg atcaccaaca
    17101 cgggggccgc gtcctgcacg ggccgtccgg tggagctgtg gagcgtcggc gccgtctcgg
    17161 cgaagaccac gtggaacaac cagcccgcca aggccgtccg gctggcgacg gtgacggacg
    17221 ccaagggccg tgagggctgc gcggccggcg acctcgaatt cgacgccacc gcgctggtga
    17281 aggaggccgc ggccacgtcc caggcctccg tcaccgtcgg tctgttcgcc gcgaacgagt
    17341 ccgacgcctc ggcctggaag cgcttcgccc cggcgaccgc gaagctggag accaccatag
    17401 gccgccccgc gccgccggtg atcagctcac ccgagttccc cgacgcctcg aacggcgccc
    17461 ccgccgacac cggcaaggcc cgcaccccgg gcacgttcac gttcggcacc ggtggcgcca
    17521 ccaacatcga gaagatcgtg tactggtcgg acttcgatcc gcgcgaggtc accgtggcac
    17581 cgggcggctc cgcggtgatc acgcccaccg gctccggtcc gcactcgatc cacgcgtaca
    17641 gcgtcgaccg ggccgggcgg cgttctgacc aggccatgta ccagttctgg gccctcggga
    17701 acggcggggt ccgcgacgcc gccggcgacc tgaacggcga cggtctgcgc gacctgtgga
    17761 ccctggaccc ggccggccgg ctccggttct cggccggccg ggccgacggc accttcgccg
    17821 cgccggtcga cgccggtgcc tccttcgctc ccggcagccg gatcgcagcc ggaggggact
    17881 ggggcgagga cggatacaac gacctgctcg tgctcgagtt cgccgagggt ctgggagcca
    17941 agcagctccg ggtcctcccc aacaacggcc tcggcagcgt ccgtccgcac gacggcatcg
    18001 tcctcagcgt cctcgaggac gacccggcgc agggcaacga ccactggtcg gatgcccagg
    18061 acatcgccga cgcgggcgac ctgaacggcg acggcgagcc cgacctgctg gtcgagcagg
    18121 gcgcgaagct ctgggcgtac acgggcagcc gctccggcta cctcgacatg aacggcgccc
    18181 cggtcctcgt cggtgacggc ggctgggaca ccgtctcggt cctcgccccg ggcgacaccg
    18241 acggcgacgg cgccggcgac ctgtgggtgc gcgacgacgc ctccggcgac ctcttcgccg
    18301 tgaagggcgc caaggacgcc gccgggcagc tcgaccccag gagctgggga acggcgcagc
    18361 gcgtgaagat cggctccggc ctcggccgga cggcctgccc gacgctcgcc gcggcggccg
    18421 acttcgaccg cgacggtctg gtcgacctgg ccgccgtcgg cgccgacggc aaggccgtct
    18481 ggttccgggc gacggccacc gggatcgacg cgaccccgcg gccgatcggc tgatcccacg
    18541 tcgaccggcc gggccggcga ccccgttcag gggcgccggc ccgctgtcgt ctccgggggc
    18601 ggctcgatga aggcgcgggt caggtgtgcg gtggcgagaa gggcgccgcg ctccctcgcc
    18661 cggtccagca gggcccggcg ggaggtgcgg gcggtgtccc ggtcgcgctc gtgggagtac
    18721 ggcaccgccg ggtcgcccag ctgcaccgca tgcaccagta cgtccccggt gaccaccacg
    18781 tcgcgggccc cgtccccctg gtccaccagc accgactggt gccccggcgt gtgtccgggc
    18841 gtcggcagca gggtgacgcc gggcaccagc cggtggacgc cgtcgacctc gtgcaatcgg
    18901 ccgcgcgcac gcagcggcgc caccgtccag tcccacaccg ggtccgcccg gtccagcgcg
    18961 gccacctccg cgcgctgcac cacgtaccgg gcctccggga agaacggttc cccgtcgtcc
    19021 cccgacgacc atcccgcgtg gtcctcgtga aggtgggtca gcaccaccgc ctccacatcg
    19081 gccggggcga taccggccac cgcgagggcg tccggcagcc gccccggcac cggggcccag
    19141 gcggcggccg gggaccgggc cggcccgacc ccggcgtcca ccagaaccca gcggccgccg
    19201 ggccgggcga tcgcgaagca ccggaaatcc agcgcccagg ccccgtccgg tccgaacgcg
    19261 cccggatcca gctccgcggc ccgcgcccac gccgcctcgc cggcccccgg aaaggcggcg
    19321 tgggcaggct cgaagaagat cccggtggcg tcgagcagcg ccaccacccg tccctgtcga
    19381 tccattcgcc tattgtgcga gacatgaccg aacaacctga ccagcaggac actttgcagc
    19441 ccatgcccac cgactggacg cgcgccctcg ccgtggtcgc gcaccccgac gacctggagt
    19501 acgggtgcgc cgcggccgtc gcggactgga cggacggggg ccgggaggtc gtctacctcc
    19561 tcgccacgcg cggcgaagcg ggcatcgaca gcatcgcccc cgccgactgc ggtccgctgc
    19621 gcgaggcgga gcagcgggcg agcgccgcgg tcgtcggggt gtccgaggtg gagttcctgg
    19681 actaccacga cggggtcatc gagtacggac tcggcctgcg ccgggacatc gccgcggcga
    19741 tccggcggca ccgccccgag ctgctcgtca ccctcaacca ccgtgacacg tggggcggtg
    19801 cgcagggcgg cggctactgg aacacccccg accacaaggc cgtcggccgg gccgtgctgg
    19861 acgcggccgg tgacgccggc aaccggtgga tcttccccga gctcatcgag cagggactgc
    19921 agccgtggga cggcgtgcgc tgggtcgcgg tcgccggatc cagcacgccc acgcacgcgg
    19981 ccgacgccgg cccggggctg gagcgctcgg tgaagtccct gatggagcac aaggcgtaca
    20041 tcgaagtgct caccgaccag gacccggagg agtacgtacg caccttcctc accgggaacg
    20101 cccagcaggc ggcggcccgg ttcggcggcc gtcccgccgt gccgttcgag gtcttccccc
    20161 gctgaccggc cacccctagt ctgacgactc gtcaattgat gagtcgtcag acagtgagac
    20221 gggggtgcgg gacacggtga tcgacaccat ctccacggag atcgcggagg gtgcggagcg
    20281 catcagactg gaggtcgcgg acggtctcgc ggtcctgacc ctgtgccgcc cggagaaact
    20341 caacggctgg agctgggagt ccacccgtca gctcggcctg ctcgcggacc ggatccgctt
    20401 cgacgcggac gtccgggcgg tgctgctgcg ggccgagggc cgggccttct gcgcgggcat
    20461 cgacgtgacc gccccgggcg gcgccatcac cggcggatcc ccggcggagc gcacccgcaa
    20521 ctactacgag ggcatccgct gggtgcacga gcggttcgcg gtcctcgccc gcctcccgca
    20581 gccggtggtg gccgccgtcc agggctactg cctcggcttc ggcttcgagt tggcgctgat
    20641 ggccgacgtc cgggtggcgg ccgaggacgc cgtcttcgcc ctgccggagg ccgggctggg
    20701 ggtggcggtg gacgcgggcg gtgacctccg tatcgcccgc gaggcgggcg cgggctgggc
    20761 caagtacctg gctctgaccg gccgccggat cgacgcgggg acggcgcagc gcctcaacct
    20821 ggtccaactg gtcgtccccg gcgatgacct ggactccgcc gcgcacgccg tggcacggga
    20881 gatcgcggcg aacgcgcccc tcgcgg
//
