LOCUS       NZ_CP020039            21353 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces sp. 3211 isolate 3 chromosome, complete genome.
ACCESSION   NZ_CP020039
VERSION     NZ_CP020039.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. 3211
  ORGANISM  Streptomyces sp. 3211
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8232231)
  AUTHORS   Heinsch,S.C., Hsu,S., Hansen,L., Kinkel,L. and Smanski,M.J.
  TITLE     Complete genomes of three Streptomyces isolated from disease
            suppressive soils
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8232231)
  AUTHORS   Heinsch,S.C., Hsu,S., Hansen,L., Kinkel,L. and Smanski,M.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-MAR-2017) Biotechnology Institute, University of
            Minnesota, 1479 Gortner Ave, Saint Paul, MN 55108, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 20-JAN-2017
            Assembly Method                   :: PacBio v. Jan-2016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: PacBio; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 03:18:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,254
            CDSs (total)                      :: 8,154
            Genes (coding)                    :: 7,815
            CDSs (with protein)               :: 7,815
            Genes (RNA)                       :: 100
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 340
            CDSs (without protein)            :: 339
            Pseudo Genes (ambiguous residues) :: 0 of 340
            Pseudo Genes (frameshifted)       :: 206 of 340
            Pseudo Genes (incomplete)         :: 257 of 340
            Pseudo Genes (internal stop)      :: 68 of 340
            Pseudo Genes (multiple problems)  :: 153 of 340
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:04:45
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7636638
            Orig. end                         :: 7657991
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP020039.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Michael Smanski.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21353
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="32"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21353
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21353
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11353](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11353
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(601..1206)
                     /locus_tag="B4U39_RS34675"
     CDS             complement(601..1206)
                     /GO_function="GO:0070273 - phosphatidylinositol-4-phosphate
                     binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003970264.1"
                     /locus_tag="B4U39_RS34675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GPP34 family phosphoprotein"
                     /protein_id="WP_053174944.1"
                     /transl_table=11
                     /translation="MSTAKDLFIIAMDPPPDRPVGQGDLSLALAGAELIDLLDAQAAAL
                     DGDRIVPGEPSELHDPLLSEAASALTRHTPYERVDEWLWRRGRDLSAAYQAALEEAGEL
                     TRGRRGLLPFGTDRMEVADTPARRRALGRQEEDEPVLAALASVVGLRSDDPEAEPRPGD
                     EAVTTVLAVVNDAVMELEAVRQRRTIENAAYANMWRSP"
     gene            1438..2034
                     /locus_tag="B4U39_RS34680"
     CDS             1438..2034
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1278: PadR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018958019.1"
                     /locus_tag="B4U39_RS34680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_079407170.1"
                     /transl_table=11
                     /translation="MALDHAILVSLLEKPGSGYELARRFDRSIGYFWTATHQQIYRVLG
                     RMEGDGLLAVREVPQQGRPDKKEYSVAGPGRAALAGWLHEPIEPESLRHDLAVKIRGVA
                     FDDPAALIQEVERHHRAHSDRLARYLAGELRDFTGPDAPAPLDAGQELQHVVLRGGIAY
                     ERMTIAWLDDVLATLHRLGATASTAATTAATTATA"
     gene            2125..3855
                     /locus_tag="B4U39_RS34685"
     CDS             2125..3855
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088719.1"
                     /locus_tag="B4U39_RS34685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_079407171.1"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 2.6e-19, bitscore:
                     68.7, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADALLFNPHTYDPAHFDPETRRLLRATVDWFESRGKRRLIEDYR
                     SRAWLADFLAFSAKEGLFATFLTPAAAAGEGESDKRWDTARIAALNEIFGFYGLDYWYA
                     WQVTILGLGPVWQSENAEARERAAQLLSEGEVFAFGLSEKSHGADIYSTDMLLQPDSDG
                     AGGFRASGSKYYIGNGNAAGLVSVFGRRTDIEGPDGYVFFAADSRHAAYHLVKNVVDSS
                     KYVSEFRLDDYPVRAEDVLHTGRAAFDAALNTVNVGKFNLCTASIGICEHAMYEAVTHA
                     HNRVLYGRPVTAFPHVRRELADAYVRLVGMKLFSDRAVDYFRTAGPDDRRYLLFNPMTK
                     MKVTTEGEKVIDLMWDVIAAKGFEKDNYFAQAAIEIRGLPKLEGTVHVNLALILKFMHN
                     HLLNPAEYPEVPTRLDAADDAFLFQQGPARGLGSVRFHDWRTAYDAYAAVPNVARFREQ
                     ADALCAFVATVAPDEEQSRDLDFLLSVGQLFALVVYGQLVLEQARLTDLDESVLDELFS
                     VLVRDFSGHAVELYGKDSATAAQQDWALGAVRRPVVDEARAARVWARVEALSGTYEMAP
                     "
     gene            complement(3942..4673)
                     /locus_tag="B4U39_RS34690"
     CDS             complement(3942..4673)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (8-168). E-value: 1.1e-12. Score:
                     40.1. Matches aSDomain:
                     nrpspksdomains_B4U39_RS34690_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015580355.1"
                     /locus_tag="B4U39_RS34690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_079407172.1"
                     /sec_met_domain="adh_short (E-value: 5.8e-34, bitscore:
                     116.4, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGIEGKIVAVTGAGSGIGEATALLLAERGAKVVLGARRTERLEA
                     LAARIEKAGGEAAWIRTDVTRRTDLVGLVDLARERYGRLDVLVGNAGVGLISPLDELRV
                     DDWEEMIDVNLKGVLYGIAAALPVFREQGSGHFVNVVSTAGLRVVPLQSVYAGTKNAVR
                     TISEGLRQEAGDSLRVTVVSPGAVRTEFTERMGPEARDRIDRMMETALSPDAVARAIAF
                     AIEQPDGVDVGDIVVRPTAQA"
     aSDomain        complement(4170..4649)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B4U39_RS34690_PKS_KR.1"
                     /evalue="1.10E-12"
                     /label="B4U39_RS34690_PKS_KR.1"
                     /locus_tag="B4U39_RS34690"
                     /protein_end="168"
                     /protein_start="8"
                     /score="40.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAVTGAGSGIGEATALLLAERGAKVVLGARRTERLEALAARIEKA
                     GGEAAWIRTDVTRRTDLVGLVDLARERYGRLDVLVGNAGVGLISPLDELRVDDWEEMID
                     VNLKGVLYGIAAALPVFREQGSGHFVNVVSTAGLRVVPLQSVYAGTKNAVRTISEG"
     CDS_motif       complement(4566..4643)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B4U39_RS34690_0001"
                     /evalue="3.30E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="B4U39_RS34690"
                     /protein_end="36"
                     /protein_start="10"
                     /score="13.3"
                     /tool="antismash"
                     /translation="VTGAGSGIGEATALLLAERGAKVVLG"
     gene            4820..5395
                     /locus_tag="B4U39_RS34695"
     CDS             4820..5395
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014057874.1"
                     /locus_tag="B4U39_RS34695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_079407173.1"
                     /transl_table=11
                     /translation="MAADAERPLRADAQRNRDKILAAAVRVFTEQGLEAHFERIAKEAG
                     VGTGTLYRNFPTREALIEAAYRNEVARLCDSVPTLLAAMPPYEALHDWTRRFIDYATAK
                     MGMADAMRAVLAAGTNPYADSRRLIQDALTSLMEACTAADAIRSDITSTDMFAALAGIA
                     LTSAGPEQRAQAERLLDLTLDGLRARRE"
     gene            5438..5818
                     /locus_tag="B4U39_RS34700"
     CDS             5438..5818
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018888497.1"
                     /locus_tag="B4U39_RS34700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4440 domain-containing protein"
                     /protein_id="WP_079407174.1"
                     /transl_table=11
                     /translation="MSRETDEVGAAIAGELRLMDPGVRTSQSLVRQLLDPHFVEVGASG
                     RRWTYEEMLAVLPEMDGSAEDGPRYEPSEMNGVLLAPGLVHLTYETVIDGNRARRSSLW
                     RRQGEGAEWQMYYHQATPCPRL"
     gene            complement(5850..6932)
                     /locus_tag="B4U39_RS34705"
     CDS             complement(5850..6932)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980456.1"
                     /locus_tag="B4U39_RS34705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_079407175.1"
                     /transl_table=11
                     /translation="MEVTRIVVIGLVIALAVVHYRRTTVDVPDRASARASRKSGLLPQS
                     RQHTGRAAPDPELEQAAAAAARGSWGPAARLMAETRERGDWARRSACAAALGSHRAARP
                     DSWLHAWEAAAGPDDADLAVVRAKALVNLAWRQRGGARAKHTSAEQFAGFHATLARVPQ
                     ESARAAELNPDDPTPYVYGIWVALGLGHPEEDMLRIWKEITTRDPYHYDAHYAALQYWC
                     AKWRGSEERAMSFAQRAAAEAPVGSLLTVLPLIAWFEHRHSDARPADFRSPHLVSLVDA
                     ALADLAAAPSNHPNAAEVRHLLAYFLTRQKRYDAALAQFRLVDGYVGALPWKYWTDPAE
                     TFCHWRDRAARRAPRARRRR"
     misc_feature    6956..6972
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.93"
                     /tool="antismash"
     gene            complement(7189..8130)
                     /gene="bla"
                     /locus_tag="B4U39_RS34710"
     CDS             complement(7189..8130)
                     /EC_number="3.5.2.6"
                     /GO_function="GO:0008800 - beta-lactamase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030655 - beta-lactam antibiotic catabolic
                     process [Evidence IEA]"
                     /GO_process="GO:0046677 - response to antibiotic [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="bla"
                     /gene_functions="resistance (resist) Exo"
                     /gene_kind="resistance"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006601733.1"
                     /locus_tag="B4U39_RS34710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class A beta-lactamase"
                     /protein_id="WP_237296934.1"
                     /transl_table=11
                     /translation="MKTQGASTSRRALLTVGAGVALAAALPVGAARAASASASASVSRH
                     GEGEVVARLRELEREYGARLGVYARDTATGRTVVHRADELFPMCSVFKTLAVAAVLRDL
                     DHGGAHLAKRIHYTLQDVTDAGGGSVTERPENIAGGLTVAQLCSAAIAQSDNLAGNLLL
                     RELGGPTAVTRFCRSLGDRTTRLDRWEPALNSAEPSRVTDTTSPRAIGRTYARLALGDA
                     LDSGDREQLNRWLLSNTTSADRLRAGLPKDWAVADKTGAGSYGTNNNVGIAWPPGRPPV
                     VLSILSTLPEPTAPRDNTLIARTAKLLADALA"
     gene            8483..9895
                     /locus_tag="B4U39_RS34715"
     CDS             8483..9895
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267883.1"
                     /locus_tag="B4U39_RS34715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_030389809.1"
                     /transl_table=11
                     /translation="MTVDTSPEAQLEPPRQSSLSTAAARNLASTTKSAPQMQEITSRWL
                     LRMLPWVETKGGTYRVNRRLTYTVGDGTIEFVQDGANVRVIPRELGELALLRGFEDDDV
                     LTALAGRCVQRDFRAGEVIVERGTPAEQIHLIAHGRISQTSVGKYGDDVAVAVLADGDR
                     FGENALLDADATWDYTATAETPGILLTLSRGDFASVLAAAPQLQAHIDRFSMLPQQRQN
                     KHGEAEIAMSAGHTGEAELPGAFVDYELKPREYELSIAQTVLRIHTRVADLYNGPHNQT
                     EEQLRLTIEALRERQEHELINNRDFGLLHNAAFKQRIQTHSGPPTPDDLDELLCRRRGS
                     KFFLAHPRTIAAIGREFNARGLYPDHVDVGGQQVPAWRGVPILPCNKIPISKENTSSVL
                     VMRTGEDNQGVIGLRQTGLPEEYEPGLSVRFMGISEQAIISYLVTTYFSAAILVPDALG
                     VLENVQIARRRD"
     misc_feature    9983..9998
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.42"
                     /tool="antismash"
     gene            10001..11353
                     /locus_tag="B4U39_RS34720"
     CDS             10001..11353
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378420.1"
                     /locus_tag="B4U39_RS34720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_079407177.1"
                     /sec_met_domain="T1TS (E-value: 3.5e-69, bitscore: 233.0,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDPGPSPLQSSLPAAAASFGAHILANALAAGVEPAAGAGPVQPS
                     PPSPPALPTGPPVLTPAAAPVPVVDESAAPAAAAAPRPNAAALDRILRGPSGLGTESLH
                     WARSEEVAAAGAATAEPAPVAGRPIPGLYHHPVPEPDPVRVEELSRRIKAWALDEVSLY
                     PDDWEDQFDGFSVGRYMVACHPDAPSIEHLMLATRLMVAENAVDDCYCEDHGGSPIGLG
                     GRLLLAHTALDPLHTTKEYAPQWEASLLSDAPRRAYRSAMEYFVQASTASQADRFRHDM
                     ARLHMGYLAEGAWAQTEYVPEVWEYLAMRQFNNFRPCPTITDSVGGYELPADLHAQPAM
                     QRVIALAGNATTIVNDLYSYTKELASPGRHLNLPVVIAERERCSDQEAYLKAVEVHNDL
                     MRDFEAAAAELALACPVPSVQRFLRGVAVWVDGNHYWHQTNTYRYSLPDFW"
     gene            11369..12256
                     /locus_tag="B4U39_RS34725"
     CDS             11369..12256
                     /EC_number="2.1.1.255"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0042214 - terpene metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015576151.1"
                     /locus_tag="B4U39_RS34725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="geranyl diphosphate 2-C-methyltransferase"
                     /protein_id="WP_053174965.1"
                     /transl_table=11
                     /translation="MTSTDLTAAAGTSSVFIPGPATPYQGDIARYWDHEARPVNLRLGD
                     VDGLYHHHYGIGDIDHAALGDPADSAYEKKLIAELHRLESAQAELLLQHLGAIERDDTL
                     VDAGCGRGGSMVMAHQRFGCKVEGVTLSAKQADFANRRAEELGIEDHVRARVCNMLSTP
                     FETGQAAGSWNNESSMYVDLHDLFAEHSRVLAVGGRYVTITGCWNPRYGQPSKWVSQIN
                     AHFECNIHSRREYLRAMADNRLVPQAVIDLTPETLPYWELRATSSLVTGIEEAFIESYK
                     DGSFQYVLIAADRV"
     gene            complement(12334..13950)
                     /locus_tag="B4U39_RS34730"
     CDS             complement(12334..13950)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1261: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007268185.1"
                     /locus_tag="B4U39_RS34730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_079407178.1"
                     /transl_table=11
                     /translation="MAGTTPQPTSRTRSWWGWGWTDAHPDDAECTAMGALLPGTLGRPL
                     PVPRVSDLEIAGPAAEPPQSLAHLVSTDRGDRAAHSMGKAYRDVARALRGRPGRIPDLV
                     ARPTDDRDVADLLDWAGERQVAVVPYGGGSSVTGGVEYRGDAHRAVMSLDLTTMGRVLE
                     VDTEGRAARIQAGTLGPSLEDQLRPHGLTLRHFPQSFEFSTLGGWLATRAGGHYATGRT
                     HIDDFVQSLRVVTPAGTSSSWRLPASGAGPSPDRLFLGSEGALGVITEAWVRLQERPRH
                     KASAAVSFTDFQDALRAVRALAQSDLSPANCRLLDAGEAALSGAAHDGSSVLVLGFESA
                     DEPVGARLERAVALARSHGARYHAADGAGGDREGSPGGDAAVGAWRSAFLRMPYLRDGL
                     VRMGAVAETFETAATWDRIPALIDEVRREVGAAAVKATGHPATVNCRLTHVYPDGAAPY
                     FTVLAAGRAGDEVAVWDELKAVASEVLHRHRATITHHHAVGRDHRPDYDRQRPEPFALA
                     LRAAKGALDPRGILNPGVLVG"
     misc_feature    13970..13986
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.13"
                     /tool="antismash"
     misc_feature    13985..14001
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.36"
                     /tool="antismash"
     gene            14015..14647
                     /locus_tag="B4U39_RS34735"
     CDS             14015..14647
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007268184.1"
                     /locus_tag="B4U39_RS34735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_079407179.1"
                     /transl_table=11
                     /translation="MATPSSKAGTKGVPREHRRRQMLEAATEEFGTHGYAAASLPAIAA
                     RVGVTKTLLHQYLGSKEDLYVACLVPVGDRLLEAVREAMGEGGAAPHTPLRVLHGIFTA
                     LEGRREAWFVLYDTTLPPGGEAARRASEYRAAIDRLAAGGTAELLRAAGSTDPLDADAL
                     KYVWRDLVATLVRWWVKHPEQTPEAMTRRCARLFAAAATLTPDGRPG"
     gene            complement(14680..15162)
                     /locus_tag="B4U39_RS34740"
     CDS             complement(14680..15162)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006601811.1"
                     /locus_tag="B4U39_RS34740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_079407180.1"
                     /transl_table=11
                     /translation="MPKKLTEAEMPTADYAFYGLVWAGTVMTDRVDRALVKAHDLPVSW
                     FEVMLWLASSPEPVPASVLGNSTLLSRSQVSRVVDALQTRGLVTRTPSARDARSVEVAL
                     TEAGRTLFAEADATRREALAPVFTELLDEQDLEALGTVWRKLKAAKAEQAEQERTR"
     gene            15251..16117
                     /locus_tag="B4U39_RS34745"
     CDS             15251..16117
                     /EC_number="1.1.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (13-175). E-value: 3e-16. Score:
                     51.8. Matches aSDomain:
                     nrpspksdomains_B4U39_RS34745_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017945614.1"
                     /locus_tag="B4U39_RS34745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_053174975.1"
                     /sec_met_domain="adh_short (E-value: 3.9e-32, bitscore:
                     110.4, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTLPTAPGSSTRTVLITGTSSGIGLAAAIAAARAGWRTVATLRD
                     TGRADALRKAAVEAGVELDIRQLDVVDEASVAAAVEGVIADYGRLDAVVNNAGAGHVGT
                     LELETVADVREVMEVNFFGVLNVSKAALPHLRATGGRLITVTSVGGVVGQPFNEAYCAA
                     KFAVEGYMESLAPVAAAVGVSVTVIEPGAVATEFVNNIDLDLEARIAAAGPYSDALRHY
                     VERTVGQFLNGAQTPEGAAESVMEALTVEHPAFRIQTSDWARDFTGNKLVDQDGSAVVG
                     MTSTWVA"
     aSDomain        15290..15775
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B4U39_RS34745_PKS_KR.1"
                     /evalue="3.00E-16"
                     /label="B4U39_RS34745_PKS_KR.1"
                     /locus_tag="B4U39_RS34745"
                     /protein_end="175"
                     /protein_start="13"
                     /score="51.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TVLITGTSSGIGLAAAIAAARAGWRTVATLRDTGRADALRKAAVE
                     AGVELDIRQLDVVDEASVAAAVEGVIADYGRLDAVVNNAGAGHVGTLELETVADVREVM
                     EVNFFGVLNVSKAALPHLRATGGRLITVTSVGGVVGQPFNEAYCAAKFAVEGYMESLA"
     gene            16668..17435
                     /locus_tag="B4U39_RS34750"
     CDS             16668..17435
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008742178.1"
                     /locus_tag="B4U39_RS34750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NPP1 family protein"
                     /protein_id="WP_237296935.1"
                     /transl_table=11
                     /translation="MRTNRHIRRSLVVLGAALTVVVAVPQVAFAAPPPALPGKAEAIEL
                     TYQPAYDYDTDGCYPTPAIGPTGVLNSGLKPTGALNGSCRDASDLANTNGYSRWKCNNG
                     WCAVIYALYFEKDQALPGIELGGHRHDWEHVVVWIQGNEAKYVATSAHGDFNIHSRDQI
                     RWDGNHPKIVYHKDGIGTHCFRAANTNDERPENHRGTWQFPTLVGWSGYPATLRDKLTQ
                     ADFGSAHFGLKDGSFASHLAEAKPAGISFDPNQ"
     misc_feature    16698..16700
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(17496..18656)
                     /locus_tag="B4U39_RS34755"
     CDS             complement(17496..18656)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005475245.1"
                     /locus_tag="B4U39_RS34755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="substrate-binding domain-containing protein"
                     /protein_id="WP_079407181.1"
                     /transl_table=11
                     /translation="MYPKDPHRRTARRSTRASAALLTASAALVAGCGGGGPSTGAAPPT
                     AGCPTVLASAGAAVAQAEKADTSWHGPTTGPAAVPGKSIVYVAQTMTNPGVAGVAKGVE
                     EAAKAIGWQVRVIDGEGTPAGIQAALSQAITLAPSGIVIGGFDPQLTSQQMARAEAARI
                     PVIGWHAVGSPGPSERPRLFTNVTTKVEDVAKISADWIIARSEGGAGVVLFTDDSIPFA
                     RNKSQLIRKQLATCPGVRLLSYENIPIPDAASRTAQAVSSLLSRFQDEWTYSVAINDLY
                     FADAAPALRAAGEPGAGPPFNIGAGDGDPSAFQRINSEQFQAATVPEPLNQQGWQIVDE
                     FNRAFAEQPASGYVAPVHIATAQNSDGATSWDPSGYREGYRRIWAG"
     gene            complement(18690..19706)
                     /locus_tag="B4U39_RS34760"
     CDS             complement(18690..19706)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1113:
                     inner-membrane translocator"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005475246.1"
                     /locus_tag="B4U39_RS34760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_079407182.1"
                     /transl_table=11
                     /translation="MTTSPPPPSPSPHRSLLDHLRGHHLGTYGLVILAALLFLVFSLVL
                     PDTFPTRDNVSSILSNQSIPAILALGATIPIATGKFDLSMGYGLGLAHVLVLQLIVNAG
                     WPWPLACLTVIVGGALVGVLNGVIVEYVRIDSFIATLGTGSMMYAATGWITDGSRIVPG
                     PEGLPASFTGLYDSRFLGLPLPAYYVIALAAALWVVLERLPLGRYMYVIGSSRRTADII
                     GIPSHRYSVYAFAGSGLVTGLAGVLLAAQQQTGNPSVGLDYLLPAFVGALLGSTTIKPG
                     RVNALGTVVAVAVLAVGLAGIGQLGADFWATPLFNGATLLIAVGLAGYSARRRLRTS"
     gene            complement(19703..21268)
                     /locus_tag="B4U39_RS34765"
     CDS             complement(19703..21268)
                     /EC_number="7.5.2.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743715.1"
                     /locus_tag="B4U39_RS34765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar ABC transporter ATP-binding protein"
                     /protein_id="WP_079407183.1"
                     /transl_table=11
                     /translation="MHDAPDTWAGPPPRSGAAPLVRMRGLSKRFGGTLALASVDLDIHR
                     GSVLALLGPNGAGKSTLIKVLAGVHHADEGHVTVDGHPLGSHAAARSMSFIHQDLGLVP
                     WMTVAENIALGTGYPRHRGLISWRRTRQRCDEALRIVAGHLEPDARIRDLGPAERSLVA
                     IARALATRAGLIVLDEPTATLPAADCARLFDVLHALRDRGHGILYVSHRLDEVYEVADT
                     FAVLRDGRLVDRGPLAGHSPDRLVRAIVGRVPAGSAQAGRVPAAPPAAAAPRLRLDGVR
                     TASTGRVGLELRAGEILGMVGLTGAGHMELGRALAGARPILEGRVLLDGRPYRPRSVHA
                     ALDAGVGFVAANRQEEGCAADLTVRENFLANPRASGAPAGHWISPRRERAEALALIDRF
                     SVHPRRSEVPIATLSGGNQQKVMVGRWLRGHLRLLVLEEPTAGVDVGAKATIHRLLDDA
                     LDSGLGVLLISTDFEEVAAVCHRALVFVRGSVSAELSGASLTVTELTRTASAMPAITGT
                     ATDR"
ORIGIN
        1 cgatggacgg cttccacctc gcgcaggccg tgctggacga cctgggccgc gccgaacgca
       61 agggcgcccc ggacaccttc gacgccgccg gctacgtcgc cctgctgcgg cggctgcgcg
      121 caccgcacgg gcccacggtg tacgcgcccg ccttcgaccg ctccttggag gagccgatcg
      181 cgggcagcat ccccgtcgcc ccggacgtac cgctggtgat caccgagggg aactacctgc
      241 tgcacgacgc gggggagtgg gccgcggtgc ggccgctgct ggacgaggcc tggtacctcg
      301 cccccgccga ggacctgcgc ctggaccggc tgatcgaccg tcatgtgcgg cacggcaagg
      361 accccgcgca cgcgcgtgcc tgggtggccc gctcggacga ggccaacgcc cggctcgtcg
      421 ccctgggccg gcaccgggcc gacctcgtcc tcgacctcgg ctgacaccgc ccgggcggcc
      481 gcacgcccct tcttcctcga cgccgcgctc ggcagcaccc cgtacccgtc gtggtggacg
      541 gctgccgacc gcggctgagc ccccgtcacg gaccgggccg gccgggccgc gcgcggggtc
      601 tcaggggctg cgccacatgt tggcgtacgc cgcgttctcg atggtccgcc gctggcgcac
      661 ggcttccagt tccatcaccg cgtcgttgac gacggccagg acggtcgtca ccgcctcgtc
      721 gcccgggcgg ggttcggcct cggggtcgtc gctgcggagg cccacgaccg aggcgagggc
      781 ggcgagtacg ggctcgtcct cctcctgacg gcccagcgcc cgtcggcggg cgggcgtatc
      841 ggccacctcc atgcggtcgg tcccgaaggg cagcaggccg cgccgtcccc gcgtcagctc
      901 accggcctcc tccagggcgg cctggtaggc cgcggacagg tcgcggccgc ggcgccacag
      961 ccattcgtcg acccgctcgt acggagtgtg gcgggtgagc gccgacgcgg cctcggacag
     1021 cagcgggtcg tgcagctccg acggctcgcc gggcacgatg cggtcgccgt ccagggcggc
     1081 ggcctgcgcg tcgaggaggt cgatcagctc ggctccggcg agggcgagcg acaggtcgcc
     1141 ctgcccgacg ggacggtccg gcggcgggtc catcgcgatg atgaacaggt ctttcgccgt
     1201 actcatgaac ggctcccctc ggagtcatcg gaaggcgcgg gtgccggcgg gggccagccg
     1261 gccggtggga ccggctgatc accttcccta tggtcgcacc aacgcccgcg agggcctcgt
     1321 ggttccccga agcacccggt aggcctactc ctcgaccagc gacgaggccg ggtgagccgc
     1381 gtctcacctg agcgccgccg cttgtctatg caacgagttg catagaagga tcggggcatg
     1441 gcgctcgacc acgcgatcct cgtctccctg ctggagaagc cgggctccgg ctacgagctg
     1501 gcccgccggt tcgaccggtc catcggctac ttctggaccg ccacccacca gcagatctac
     1561 cgcgtgctgg ggcggatgga gggcgacggg ctgctcgccg tccgcgaggt gccgcagcag
     1621 ggccggccgg acaagaagga gtactccgtc gccggtcccg gccgcgccgc cctcgccgga
     1681 tggctgcacg agccgatcga acccgagagc ctgcgccacg acctcgccgt caagatccgc
     1741 ggcgtggcct tcgacgaccc ggccgcgctc atccaggagg tcgagcggca ccaccgggcg
     1801 cacagtgacc ggctggcccg ctatctcgcc ggtgaactgc gcgacttcac cgggccggac
     1861 gcccccgcgc cgctcgacgc cggtcaggag ctccagcacg tcgtgctgcg cggcggcatc
     1921 gcgtacgagc ggatgacgat cgcctggctc gacgacgtcc tcgccacgct gcaccggctc
     1981 ggcgcgaccg catcgaccgc cgccaccact gccgccacca ccgccaccgc ctgaacccca
     2041 cggccgcacc gccgtacgcg ccgccgcacc gccgcggcgc cccctccacg cgcccgaccc
     2101 caacccctcg gaaggtgaac ctccatggca gacgccctgc tcttcaaccc gcacacctac
     2161 gacccggcgc acttcgaccc cgagacccgc aggctgctgc gcgccaccgt cgactggttc
     2221 gagagccgcg gcaagcgccg gctgatcgag gactaccgct cccgcgcatg gctggcggac
     2281 ttcctcgcgt tctccgcgaa ggaggggctc ttcgcgacct tcctgacccc ggccgccgcc
     2341 gcgggtgagg gggagtcgga caagcgctgg gacaccgccc ggatcgcggc cctgaacgag
     2401 atcttcggct tctacggcct cgactactgg tacgcctggc aggtcaccat cctcggcctg
     2461 ggcccggtct ggcagagcga aaacgccgag gcccgcgagc gcgccgcgca gctcctctcc
     2521 gagggcgagg tgttcgcctt cggcctgtcc gagaagagcc acggcgccga catctactcc
     2581 accgacatgc tgctgcagcc cgacagcgac ggtgccggcg gattccgcgc gagcggctcc
     2641 aagtactaca tcggcaacgg caacgccgcc ggcctcgtct cggtcttcgg ccgccgcacc
     2701 gacatcgagg gccccgacgg ctacgtcttc ttcgccgccg acagccgcca cgcggcgtac
     2761 cacctcgtga agaacgtcgt cgactcctcc aagtacgtca gcgagttccg cctcgacgac
     2821 tacccggtcc gcgccgagga cgtcctgcac accggccggg ccgccttcga cgccgccctg
     2881 aacaccgtca acgtcggcaa gttcaacctc tgcaccgcct ccatcggcat ctgcgagcac
     2941 gcgatgtacg aggccgtcac ccacgcgcac aaccgcgtcc tgtacggccg ccccgtcacc
     3001 gccttcccgc acgtgcgtcg ggagctggcc gacgcgtacg tccgcctggt cggcatgaag
     3061 ctcttcagcg accgcgccgt cgactacttc cgcaccgccg gcccggacga ccgccgttac
     3121 ctgctcttca acccgatgac gaagatgaag gtgaccaccg agggcgagaa ggtcatcgac
     3181 ctgatgtggg acgtcatcgc cgccaagggc ttcgagaagg acaactactt cgcgcaggcg
     3241 gccatcgaga tccgcggcct ccccaagctg gagggcacgg tccacgtcaa cctggccctg
     3301 atcctcaagt tcatgcacaa ccacctgctg aacccggccg agtaccccga ggtgccgacc
     3361 cgtctcgacg cggccgacga cgccttcctg ttccagcagg gaccggcccg gggcctgggc
     3421 tccgtacgct tccacgactg gcggaccgcc tacgacgcgt acgccgccgt gccgaacgtg
     3481 gcacggttcc gcgaacaggc cgacgccctc tgcgcgttcg tggccaccgt cgcgccggac
     3541 gaggagcaga gccgtgacct cgacttcctc ctctccgtgg gccagctgtt cgcgctggtc
     3601 gtctacgggc agctggtcct ggagcaggcc cgcctgacgg acctggacga gtccgtgctt
     3661 gacgaactgt tctccgtgct cgtgcgcgac ttctccggcc acgccgtcga gctgtacggc
     3721 aaggactcgg ccaccgcggc ccagcaggac tgggcgctcg gcgcggtccg gcgcccggtc
     3781 gtggacgagg cgcgcgcggc gcgcgtctgg gcccgggtcg aggcgctgtc cggcacgtac
     3841 gagatggctc cgtaggcagc ggcgcgcggg ggaccggcac accgccgccg gcggtgtgcc
     3901 ggtccccctg cggtttgccg tccgccgtcc gccgtccgcc gtcaggcctg tgctgtgggg
     3961 cgtacgacga tgtcgcccac gtcgacaccg tccggctgct cgatggcgaa ggcgatggcg
     4021 cgggccaccg cgtccggcga cagcgcggtc tccatcatgc ggtcgatccg gtcccgggcc
     4081 tctggtccca tgcgctccgt gaattccgta cggacggcgc cgggcgacac gacggtcacg
     4141 cgcaggctgt ccccggcctc ctggcgcagg ccctcggaga tcgtgcgcac ggcgttcttg
     4201 gtgcccgcgt acacggactg gagcggcacg acccgcagtc cggcggtgga cacgacgttg
     4261 acgaagtggc cggagccctg ttcccggaag acggggagcg ccgctgcgat cccgtagagg
     4321 acgcccttca ggttgacgtc gatcatctcc tcccagtcgt cgacgcgcag ctcgtcgagc
     4381 ggggagatca atccgacccc ggcattgccg acgagcacgt cgagcctgcc gtaccgctct
     4441 cgcgccaggt cgacgaggcc caccaggtcg gtgcgccgcg tcacgtccgt acggatccag
     4501 gcggcctcgc cgccggcctt ctcgatgcgg gcggccagag cctcaaggcg ctccgtgcgg
     4561 cgtgcgccga ggaccacctt cgcgccccgc tcggcgagca ggagggcggt ggcctcgccg
     4621 atgccgctgc ccgcgccggt gacggccacg atcttgcctt cgattcccga catggcggga
     4681 gtcccttcgg aagaggaatg gggcaggccg aggccatgcc ctagagtgaa agtggaggcg
     4741 ccgccacttc agccaggcta agtggaggcc cctccagtta gcaagcgggt gccgatgagg
     4801 aagcagggga gggccgttga tggccgcaga cgcagaacgc ccgctgaggg ccgacgcaca
     4861 gcgcaaccgg gacaagatcc tggctgccgc ggtgcgcgtg ttcaccgagc agggcctgga
     4921 ggcgcacttc gagcgcatcg ccaaggaggc cggcgtgggc accggcaccc tctaccgcaa
     4981 cttccccacc cgcgaagccc tgatcgaggc ggcctaccgg aacgaggtcg cccgcctgtg
     5041 cgactccgtc cccaccctcc tggcggccat gccgccgtac gaggccctgc acgactggac
     5101 gcgtcgcttc atcgactacg cgaccgccaa gatgggcatg gcggacgcga tgcgcgccgt
     5161 cctcgcggcg gggaccaacc cctacgccga cagccgccgg ttgatccagg acgcgctcac
     5221 ctccctgatg gaggcctgca ccgccgcgga tgcgatcagg tccgacatca cctcgaccga
     5281 catgttcgcc gccctcgccg gcatcgccct cacctcggcc ggacccgaac aacgggccca
     5341 ggccgaacgc ctcctcgacc tcaccctgga cggcctccga gcccgacgtg agtaacccgg
     5401 ttgcggctgc tccggtcgcc tggacgaaga tgcctgtatg agcagagaga ccgacgaggt
     5461 gggcgcagcg atcgcgggtg agctgcgtct gatggaccca ggcgtgcgca cgtcgcagtc
     5521 gctggtccgg cagctcctcg acccgcactt cgtggaagtg ggcgcctcgg gccggcggtg
     5581 gacgtatgag gaaatgctcg ccgtgctgcc ggagatggac ggttcggcgg aagacggccc
     5641 gcgctatgag ccctcggaga tgaacggtgt cctgctggca cccgggctgg tgcacctcac
     5701 ctacgagacc gtgatcgacg gaaatcgggc ccggcggagc tcgctgtggc gccggcaggg
     5761 cgagggagcc gagtggcaga tgtactacca ccaggccacc ccctgtccga ggctttaggg
     5821 cgccgccggg gccgaccggc gccggcggtt cagcggcggc ggcgggctcg gggggctcgg
     5881 cgggccgcgc ggtcgcgcca gtggcagaag gtttctgccg ggtcggtcca gtacttccac
     5941 gggagggcgc ccacgtagcc gtcgaccaga cggaactgcg ccagcgccgc gtcgtaccgc
     6001 ttctgccggg tcaggaagta ggccagcagg tgacgcacct cggcggcgtt cggatggttc
     6061 gagggagccg cggcgaggtc ggccagagcg gcatcgacca gcgagaccag gtgcggtgag
     6121 cggaagtcgg cgggacgcgc gtccgagtga cggtgctcga accaggcgat cagcggcagc
     6181 acagtgagca ggctgccgac cggcgcctcg gccgccgccc gctgcgcgaa ggacatggcg
     6241 cgctcctccg agccgcgcca cttcgcgcac cagtactgga gcgccgcgta gtgcgcgtcg
     6301 tagtggtacg ggtcgcgggt ggtgatctcc ttccagatcc gcagcatgtc ctcttcgggg
     6361 tggccgaggc ccagcgccac ccatatcccg tagacgtacg gcgtcgggtc gtccgggttc
     6421 aactcggccg cgcgggcgct ctcctgcggt acccgggcca gcgtggcgtg gaatccggcg
     6481 aactgctccg cgctggtgtg cttcgcccgg gcgccgccac gctgccgcca ggccaggttg
     6541 accagcgcct tcgcccgtac caccgcgagg tcggcgtcgt ccggcccggc agcggcctcc
     6601 cacgcgtgca accagctgtc ggggcgcgcg gctcggtggg agccgagggc ggcggcgcag
     6661 gcggagcggc gtgcccagtc gccgcgctcc cgggtctcgg ccatcaatcg tgcggccggc
     6721 ccccaactgc ccctggcggc cgcggcggcc gcctgctcca gctcgggatc gggcgccgcc
     6781 cggccggtgt gctgcctgga ctgcggaagc agccccgact tccgggaggc gcgggccgaa
     6841 gcccggtccg ggacatcgac ggtggtgcgg cggtagtgga cgaccgccag ggcgatgacg
     6901 agcccgatga cgacgatgcg tgtgacttcc acggtgggag cccctgaggg aggagtgatc
     6961 gaaaagtggg gacccgggag tatgacgtgg tggtgcgatc gtccgcaaat acgtttccgc
     7021 tggtggggcg gcatcacggc gcccgcaccg caaggtcttc cggtaccggc ccggggctac
     7081 ctccgctgcc gttcggcccg cggcatgccg tacgccccgg cccgccggga accccgctcc
     7141 gcctcgtcga ggccgagcgg gggcgccggc ggcccgtatg gtccgccgtc aggcgagcgc
     7201 gtccgccagc agcttcgcgg tgcgggcgat cagcgtgttg tcgcgcggcg ccgtcggctc
     7261 cggcagggtc gacaggatgg acaggaccac cggcgggcgt cccggcggcc aggcgatgcc
     7321 cacgttgttg ttcgtcccgt acgatccggc gcccgtcttg tccgcgacgg cccagtcctt
     7381 cggcaggccg gcccgcaggc ggtcggcact ggtggtgttg gacagcagcc accggttcag
     7441 ctgctcacgg tccccggagt ccagcgcgtc gccgagcgcg aggcgggcgt acgtccgccc
     7501 gatcgcccgg gggctcgtgg tgtccgtcac ccgcgagggc tccgccgagt tcagcgcggg
     7561 ctcccaccgg tcgagccggg tcgtacggtc gcccagcgag cggcagaagc gggtgaccgc
     7621 ggtggggccg ccgagctcgc gcagcagcag gttgcccgcc aagttgtcgc tctgggcgat
     7681 ggcggcggag cagagttgcg ccacggtgag gccgcccgcg atgttctcgg gccgttccgt
     7741 gaccgagccg ccgcccgcgt cggtgacgtc ctggagcgtg tagtggatgc gcttggcgag
     7801 gtgggcgccg ccgtggtcga ggtcacgcag cacggcggcc accgcgagcg tcttgaacac
     7861 cgagcacatg gggaacagtt cgtcggcccg gtgcaccacg gtgcgtccgg tggccgtgtc
     7921 ccgcgcgtac acccccagcc gcgccccgta ctcgcgctcc agctcgcgca gtcgcgccac
     7981 gacctccccc tcgccgtgcc gggacacgga cgcggaggcg gacgcggatg cggcacgggc
     8041 cgcgcccacc ggcagcgcgg cggccagcgc cacccccgcc cccacggtca gcagtgcgcg
     8101 acgggacgtt gatgcgccct gggtcttcac gtcgggttct cctcttcctg gccggtcatg
     8161 tgagagcgaa gacatcaaac gtgatcattt cggttccgcg tgcaagcggt ccgcggggcg
     8221 tgcgacgcac cgcttttcag ccgctcttgg gccgtgttcg tgaacaaggc cgaatatcat
     8281 ccataacccc ggcaaaccac ctgccggaca agatcactgc attgagctaa cgccaacggt
     8341 tttcaggctc aagtgggcgt accgggacgt tactgttccc ccggatctgg acggattccc
     8401 tgatattcgc cccccttttt cctcgttctc tggtgacgcg cgtacccgcg gaccaccgcc
     8461 cttacgaagg agagctcgcc cgatgaccgt tgacaccagc ccggaagcgc agttggagcc
     8521 gccgcggcag tccagcctga gcacggccgc cgcccgcaac cttgccagca cgaccaagtc
     8581 cgccccgcag atgcaggaga tcacctcccg ctggctgctg cggatgctcc cctgggtgga
     8641 gaccaagggc gggacctacc gggtcaaccg ccgactgacg tacaccgtcg gcgacgggac
     8701 catcgagttc gtccaggacg gcgcgaacgt ccgcgtgatc ccgcgcgagc tcggcgaact
     8761 ggccctgctg cgcggcttcg aggacgacga cgtgctgacc gcgctcgccg gccgctgcgt
     8821 ccagcgcgac ttccgtgccg gtgaggtgat cgtcgagcgc ggtacccccg ccgagcagat
     8881 ccacctgatc gcccacggcc ggatcagcca gacctccgtc ggcaagtacg gtgacgacgt
     8941 cgccgtcgcg gtcctcgcgg acggcgaccg gttcggcgag aacgccctgc tggacgccga
     9001 cgccacctgg gactacacgg ccaccgccga gacccccggc atcctgctca ccctctcccg
     9061 cggcgacttc gcctccgtgc tcgccgcggc gccgcagctc caggcccaca tcgaccggtt
     9121 cagcatgctc ccgcagcagc gccagaacaa gcacggcgag gccgagatcg cgatgtcggc
     9181 cggccacacc ggcgaggcgg agctgcccgg cgccttcgtg gactacgagc tcaagccgcg
     9241 cgagtacgaa ctctccatcg cccagaccgt gctgcgcatc cacaccaggg tcgccgacct
     9301 gtacaacggg ccgcacaacc agaccgagga gcagctcagg ctgaccatcg aggcgctgcg
     9361 cgagcgccag gagcacgagc tgatcaacaa ccgggacttc ggtctgctcc acaacgccgc
     9421 cttcaagcag cggatccaga cccactccgg cccgcccacc ccggacgacc tcgacgagct
     9481 cctgtgccgc cgccgcggct ccaagttctt cctcgcgcac ccccggacga tcgccgcgat
     9541 cgggcgcgag ttcaacgccc gggggctcta cccggaccac gtcgacgtcg gcgggcagca
     9601 ggtcccggcc tggcgcgggg tcccgatcct gccctgcaac aagatcccga tcagcaagga
     9661 gaacaccagc tcggtgctcg tcatgcgaac gggcgaggac aaccagggcg tcatcggcct
     9721 gcgccagacc ggacttcccg aggagtacga gccgggcctg tcggtccgct tcatggggat
     9781 cagcgaacag gcgatcatct cctacctggt caccacctac ttctccgccg ccatcctggt
     9841 gcccgacgcg ctcggtgtgc tggagaacgt gcagatcgcc cgcaggcggg actaagagga
     9901 cctgcccgac ggccgcgaca gccaggaccc gtgcctgtcc tggcccgccg agcatgcccg
     9961 ggattcggga caaaccactt acgtcaccaa ggagttacgg atgcccgatc ctgggccttc
    10021 ccctctgcag tcgagcctgc ctgccgccgc ggcctccttc ggggcccaca tcctcgccaa
    10081 cgccctggcc gccggtgtcg aacccgccgc cggcgccggg cccgtccagc cctcaccgcc
    10141 ctcgccgccc gccctgccca ccggtccccc cgtactgacg cccgcagccg cacccgtacc
    10201 cgtggtcgac gagagcgcgg cccccgctgc cgccgccgcg ccgcggccga acgccgccgc
    10261 cctggaccgg atcctgcgcg ggcccagtgg cctgggcacg gagagcctgc actgggcccg
    10321 cagcgaggag gtggccgcgg cgggcgccgc gaccgccgag ccggcgccgg tcgcgggccg
    10381 tccgatcccg ggcctctacc accacccggt gccggagccc gatccggtgc gggtggagga
    10441 gctcagccgc aggatcaagg cctgggcgct ggacgaggtc tcgttgtatc cggacgactg
    10501 ggaggaccag ttcgacggct tctccgtcgg gcgctacatg gtcgcctgcc atccggacgc
    10561 ccccagcatc gagcacctga tgctcgccac ccgcctgatg gtcgccgaga acgcggtcga
    10621 cgactgctac tgcgaggacc acggcggttc gcccatcggc ctcggcggac ggctgctgct
    10681 ggcccatacc gccctcgatc cgctgcacac gacgaaggag tacgcgccgc agtgggaggc
    10741 gtcgctgctc tcggacgcac cccggcgcgc ctaccgctcc gccatggagt acttcgtcca
    10801 ggcgagcacc gcctcccagg ccgaccggtt ccgccacgac atggcccgac tgcacatggg
    10861 ctatctcgcc gaaggggcct gggcgcagac ggagtacgtc ccggaggtgt gggagtacct
    10921 ggcgatgcgg cagttcaaca acttccgccc ctgccccacc atcaccgact cggtcggcgg
    10981 gtacgaactg cccgcggacc tccacgcgca gcccgccatg cagcgcgtga tcgcgctcgc
    11041 cgggaacgcc accacgatcg tcaacgacct ttactcctac accaaggaac tggccagtcc
    11101 cggacgccac ctgaacctgc cggtggtgat cgccgaacgc gagaggtgct ccgaccagga
    11161 ggcctatctg aaggcggtgg aggtccacaa cgacctcatg cgcgacttcg aggccgcggc
    11221 cgccgagctg gccctcgcct gccccgtccc gagcgtgcag cgcttcctgc ggggcgtggc
    11281 cgtatgggtc gacggcaacc actactggca ccagaccaac acctatcgct acagcctgcc
    11341 cgatttctgg taaagatggg aattgtccat gactagcact gatctcaccg ccgctgccgg
    11401 tacctcctcc gtgttcatcc ccggcccggc gaccccttat cagggtgaca tcgcccgtta
    11461 ctgggaccac gaggccaggc ccgtgaacct ccggctcggc gacgtcgacg gcctttacca
    11521 ccaccactac ggcatcggcg acatcgacca cgccgctctc ggtgaccccg ccgacagcgc
    11581 ctatgagaag aagctgatcg ccgagctcca ccgcctggag tcggcgcagg ccgaactgct
    11641 cctccagcac ctcggcgcca tcgagcgcga cgacaccctc gtcgacgccg gctgcggccg
    11701 cggcggctcc atggtcatgg cccaccagcg cttcgggtgc aaggtggagg gggtcaccct
    11761 gtcggccaag caggccgact tcgccaaccg gcgcgccgag gaactcggca tcgaggacca
    11821 cgtccgggcc cgcgtctgca acatgctcag cacccccttc gagaccgggc aggccgcggg
    11881 ctcgtggaac aacgagtcga gcatgtacgt cgacctccac gacctgttcg ccgagcactc
    11941 ccgcgtcctc gcggtcggcg gccggtacgt gaccatcacc ggctgctgga acccgcggta
    12001 cggccagccc tcgaagtggg tctcccagat caacgcgcac ttcgagtgca acatccactc
    12061 ccgccgcgag tacctgcgcg cgatggccga caaccgcctc gtgccgcagg ccgtgatcga
    12121 cctgaccccc gagacgctgc cgtactggga gctgcgggcc acgtcctccc tggtcaccgg
    12181 catcgaggag gcgttcatcg agtcctacaa ggacggctcc ttccagtacg tcctcatcgc
    12241 ggccgaccgc gtctgagcgg acgccaccga cgccggccga aggggccggg gccgtcgtcc
    12301 gacggccccg gcccctgggc ggcccggccc cgatcagccc accagcaccc cggggttgag
    12361 gatgccccgc ggatcgagcg cccccttcgc ggcccgcagg gcgagggcga agggctcggg
    12421 gcgctggcgg tcgtagtccg ggcggtggtc ccggccgacg gcgtggtggt gggtgatggt
    12481 ggcccggtgg cggtgcagga cctcgctcgc gacggccttg agttcgtccc agacggccac
    12541 ctcgtcaccg gcccggccgg ccgcgaggac ggtgaagtag ggcgcagcgc cgtccggata
    12601 cacgtgtgtc agacggcagt tgacggtcgc ggggtgtccg gtggccttga ccgccgccgc
    12661 gccgacctcc ctgcgtacct cgtcgatcag tgcggggatc cggtcccagg tggccgccgt
    12721 ctcgaaggtc tccgccaccg cccccatcct gaccagaccg tcgcggaggt agggcatccg
    12781 caggaaggcc gagcgccacg ctccgacggc cgcgtcgccg ccgggggacc cctcccggtc
    12841 gccgccggcc ccgtccgccg cgtggtaccg ggcaccgtgc gagcgggcca gcgcgacggc
    12901 ccgttcgagg cgggcaccca ccggttcgtc cgccgactcg aatcccagca ccagtacgga
    12961 gctgccgtcg tgcgccgcac ccgacagtgc ggcctcaccg gcgtccagca gccggcagtt
    13021 ggcgggggag aggtcggact gcgcgagggc gcgcaccgcc cggagcgcgt cctggaagtc
    13081 cgtgaaggag accgcggcgg aggccttgtg gcgggggcgt tcctggaggc ggacccaggc
    13141 ttcggtgatg acgccgaggg ctccctcgga gccgaggaac aggcggtcgg gggaggggcc
    13201 cgccccggag gcgggcagcc gccacgaact gctggtgccg gccggggtga cgacgcgcag
    13261 cgactgcacg aagtcgtcga tgtgggtccg gccggtggcg tagtggccgc cggcccgggt
    13321 ggcgagccag ccgccgagcg tggagaactc gaagctctgc gggaagtgcc gcagggtcag
    13381 gccgtgcggg cgcagctggt cctccaggct cggcccgagg gtgccggcct ggatgcgggc
    13441 cgcccggccc tcggtgtcga cctccagcac gcggcccatc gtggtcaggt cgagggacat
    13501 cacggcccgg tgggcatcgc cgcggtactc gacgcccccg gtgaccgagg atcccccgcc
    13561 gtaggggacg acggcgacct gtcgttcccc ggcccagtcc agcagatcgg ccacgtcccg
    13621 gtcgtccgtg ggccgggcca cgaggtcggg gatccggccg gggcggccgc gcagggcgcg
    13681 cgccacgtcg cggtaggcct tgcccatgga gtgggcggcg cggtccccgc gatcggtgct
    13741 gaccaggtgg gcgaggctct gcgggggttc ggcggcgggg ccggcgatct ccaggtcgct
    13801 cacgcggggc acggggagcg ggcggccgag ggtgccgggg agcagggcgc ccatcgcggt
    13861 gcattccgcg tcgtcgggat gggcgtccgt ccagccccag ccccaccagg agcgggtgcg
    13921 ggacgtgggc tgcggggtgg tgccggccat ggcggcgctc caggggtcga ggtaatttac
    13981 ctagcggtaa attacctact gataatatcg gcgcatggca accccttcct cgaaagccgg
    14041 caccaaggga gtcccgcggg agcaccgccg ccggcagatg ctggaggcgg ccacggagga
    14101 gttcggcacc catggctacg ccgccgcctc gctccccgcg atcgccgctc gggtgggcgt
    14161 caccaagacg ctgctgcacc agtacctcgg cagcaaggag gacctgtacg tcgcctgcct
    14221 ggtgcccgtc ggggaccggc tgctggaggc cgtccgcgag gcgatgggcg agggcggggc
    14281 cgcgccgcac accccgctgc gcgtgctcca cggcatcttc accgccctgg aaggccggcg
    14341 ggaggcatgg ttcgtgctct acgacaccac cttgccgccc ggtggtgagg cggctcgccg
    14401 ggcctcggag tacagggcgg ccatcgaccg gctggctgcg ggcggtaccg cggaactgct
    14461 gcgcgcggcc ggctccacgg acccgctgga cgccgacgcc ctcaagtacg tctggcggga
    14521 cctcgtcgcc accctcgtcc gctggtgggt caagcacccg gagcagacgc cggaggccat
    14581 gacccgccgc tgcgcccgcc tcttcgcggc cgccgccacc ctcacccccg acggccggcc
    14641 cggctgacgg gggcccgcgg cgcggcgggc ctgcggggtc tacctggtgc gctcctgctc
    14701 ggcctgttcg gccttcgcgg ccttgagctt gcgccatacg gtgcccagcg cctccaggtc
    14761 ctgctcgtcg aggagctcgg tgaagaccgg ggccagggcc tcccgccggg tcgcgtcggc
    14821 ctcggcgaag agcgtacgac ccgcctcggt gagggcgacc tccaccgacc gcgcgtcgcg
    14881 cgccgagggc gtacgggtga ccaggccccg ggtctgcagg gcgtccacca cgcgggagac
    14941 ctggctgcgg ctgagcaggg tgctgttgcc gaggacggaa gcgggcaccg gctccgggct
    15001 ggaagccagc cacagcatga cctcgaacca ggacacgggc aggtcgtgcg ccttgaccag
    15061 ggcccggtcg acgcggtcgg tcatgacggt cccggcccac accagcccgt agaaggcgta
    15121 gtcggccgtc ggcatctcgg cttcggtgag cttcttcggc atgtcggcag tctagagctt
    15181 gcgtgcgcac gcacataatt ttatggtgtg tgtgcacgca cataaatcac ccctcgtgaa
    15241 aggcgccgcc atgtccaccc tccccaccgc tcccggcagc tccacccgca ccgttctgat
    15301 caccggcacc tcctccggca tcggcctggc cgccgcgatc gccgcggctc gcgccggctg
    15361 gcggacggtc gccaccctgc gtgacaccgg ccgagccgac gccctgcgca aggccgcagt
    15421 cgaggcgggc gtggagctcg acatccgaca gctcgacgtc gtcgacgagg cctccgtcgc
    15481 cgccgccgtg gaaggcgtga tcgccgacta cggccggctc gacgccgtcg tgaacaacgc
    15541 cggcgccggg cacgtgggca ccctggagct ggaaaccgtc gccgacgtcc gtgaggtcat
    15601 ggaggtcaac ttcttcggcg tgctgaacgt ctccaaggcg gccctgccgc acctgcgggc
    15661 caccggcggc cgcctgatca cggtcaccag cgtcggcggc gtcgtcggcc agcccttcaa
    15721 cgaggcctac tgcgccgcca agttcgccgt cgaggggtac atggagagtc tggcacccgt
    15781 cgcggccgcc gtcggggtga gcgtcaccgt catcgagccg ggcgccgtgg cgaccgagtt
    15841 cgtgaacaac atcgacctcg acctcgaagc ccgcatcgcc gcggccggcc cctactccga
    15901 cgcgctgcgc cactacgtcg agcgcaccgt cggccagttc ctgaacggcg cgcagacgcc
    15961 cgagggtgcc gccgagtccg tcatggaggc cctgaccgtg gagcaccccg cgttccgcat
    16021 ccagacctcc gactgggccc gcgacttcac cgggaacaag ctggtcgacc aggacggctc
    16081 ggcggtcgtc ggcatgacct cgacctgggt ggcctagcga cggcccggca ggggcggcgc
    16141 gccgacctgt gccgcgcgcg gaaccgggtc atcatggccg aaggcggacg agtcgcccgt
    16201 gcggtcccct ccggtggccg cgcgcggcgg gcgcgtaccg cccgagccgg gaggtgactc
    16261 gtacgcatgg acgaatcgcg caaggcctgg atcatgatcg gcgccgtcgt cgccgtcatc
    16321 ctcctcgacc tcatggccat catcctgatg aacgtcctct gacgatgacc gtgtgacaca
    16381 ccgccgccgc ccccggtcgt acccggggcg gcggcggtgt tcgtccatcc gcctgtccat
    16441 ccgcctgtcc atccgtccgc gccatcgcgc cgcccacccc tgacattgcg ccaacttccc
    16501 ttgcgtacac ggcctttccg gcccaatcgg catgcaggga accgagtccg cccagcccct
    16561 tgccgcgcca caccggttcg cgaatgatgc tcccggcgtg tcggtcgacg gtgccccgtc
    16621 gcgatgcgtc cgccacccct cgcacccggt cggccaggag gcccgttttg cggacgaacc
    16681 gtcacatacg gagatcatta gtggttctcg gcgccgccct cacggtggtc gtcgccgtcc
    16741 cccaggtggc cttcgcggcg ccgcccccgg cgctccccgg caaggccgag gcgatcgagc
    16801 tgacctacca gccggcctac gactacgaca ccgacggctg ctacccgaca cccgccatag
    16861 gcccgaccgg cgtgctgaac agcggcctca agcccaccgg cgccctcaac ggcagctgcc
    16921 gggacgcctc ggacctcgcc aacaccaacg gctactcccg ctggaagtgc aacaacggct
    16981 ggtgcgccgt catctacgcg ctgtacttcg agaaggacca ggccctgccc ggcatcgagc
    17041 tcggcggcca ccgccacgac tgggagcacg tggtcgtctg gatccagggc aacgaggcca
    17101 agtacgtcgc gacctccgcc cacggggact tcaacatcca ctcccgcgac cagatccgct
    17161 gggacggcaa ccaccccaag atcgtctacc acaaggacgg catcggcacg cactgcttcc
    17221 gcgcggccaa caccaacgac gagcggcccg agaaccaccg cggcacctgg cagttcccca
    17281 cgctcgtcgg ctggtcgggc tatccggcga ccctgcggga caagctcacc caggccgact
    17341 tcggcagcgc gcacttcggc ctgaaggacg gctccttcgc ctcccacctg gcggaggcca
    17401 aaccggcggg catctccttc gaccccaacc agtagaacgg gccgccgggc accggccccg
    17461 caccgcgcgg gaccggtgcc cgtactgccg tgccgtcagc ccgcccagat cctgcggtac
    17521 ccctcgcggt atccggacgg gtcccaggag gtggcgccgt cgctgttctg cgccgtggcg
    17581 atgtgcacgg gcgccacgta gccgctggcg ggctgctcgg cgaaggcgcg gttgaactcg
    17641 tcgacgatct gccagccctg ctggttgagc ggctcgggga cggtggcggc ctggaactgc
    17701 tcgctgttga tccgctggaa ggcggagggg tccccgtcac ccgcaccgat gttgaagggc
    17761 ggcccggccc ccggttcgcc ggccgcccgc agggccgggg ccgcgtcggc gaagtagagg
    17821 tcgttgatgg cgaccgagta cgtccattcg tcctggaagc gcgagagcag cgaggagacg
    17881 gcctgcgcgg tgcggctcgc ggcgtccggg atggggatgt tctcgtacga gagcaggcgt
    17941 acgccgggac aggtggcgag ctgcttgcgg atcagctgcg acttgttccg ggcgaagggg
    18001 atcgagtcgt cggtgaacag gacgacaccg gcaccgccct cggaccgggc gatgatccaa
    18061 tccgcgctga tcttcgccac gtcctccacc ttcgtggtga cgttggtgaa cagcctgggg
    18121 cgctcgctcg ggccggggga gcccaccgcg tgccagccga tgaccgggat ccgcgccgcc
    18181 tcggcccgtg ccatctgctg cgaggtcagc tggggatcga agccgccgat gacgatgccc
    18241 gagggcgcca gggtgatggc ctggctgagc gccgcctgga tcccggcggg cgtcccttcc
    18301 ccgtcgatca cccggacctg ccagccgatg gccttcgcgg cctcctcgac gcccttcgcg
    18361 acgcccgcga cgccggggtt ggtcatggtc tgcgcgacgt agacgatcga cttgccgggc
    18421 accgccgcgg ggccggtggt cgggccgtgc caggaggtgt cggccttctc ggcctgcgcc
    18481 acggccgccc cggcgctcgc gaggacggtg gggcagcccg ccgtgggcgg cgcggcgccg
    18541 gtggaggggc cgccgccccc gcagccggcg acgagggcgg cgctcgcggt cagcagggcg
    18601 gcgctcgcgc gggtgctccg gcgggcggtt ctgcggtgcg ggtccttcgg gtacacggtg
    18661 ctcctgacgc ggtgcgcgta cggacttttc taggaggtgc gcagtcggcg gcgggcggag
    18721 tagccggcca ggccgacggc gatgagcagg gtggcgccgt tgaacagcgg tgtggcccag
    18781 aagtcggcgc cgagctggcc gatgccggcg aggccgacgg cgaggacggc gacggccacg
    18841 acggtgccga gggcgttgac gcggccgggt ttgatcgtgg tggaacccag gagggcgccg
    18901 acgaaggcgg gcagcaggta gtccagcccg acgctcgggt tcccggtctg ctgctgggcg
    18961 gcgaggagga ccccggcgag gccggtgacc aggcccgatc cggcgaaggc gtagacggag
    19021 taccggtggc tggggatgcc gatgatgtcg gcggtgcgcc ggctggagcc gatgacgtac
    19081 atgtaccggc cgaggggcag ccgctccagg accacccaga gcgcggccgc gagggcgatg
    19141 acgtagtagg cgggcagggg caggccgagg aaccgggagt cgtagaggcc ggtgaaggag
    19201 gcgggcaggc cctccgggcc ggggacgatc cgggagccgt cggtgatcca gccggtggcg
    19261 gcgtacatca tgctgccggt gccgagggtg gcgatgaagg agtcgatccg cacgtactcg
    19321 acgatgacgc cgttgaggac gccgaccagt gccccgccga cgatgacggt caggcaggcg
    19381 agcggccagg gccagccggc gttgacgatc agctggagca ccagcacgtg ggccaggccg
    19441 aggccgtagc ccatcgacag gtcgaacttt ccggtggcga tggggatcgt cgcgccgagc
    19501 gcgaggatgg cggggatgga ctggttggag aggatcgagg agacgttgtc ccgggtgggg
    19561 aaggtgtccg gcaggacgag ggagaagacc aggaacagca gggcggcgag gatcaccagg
    19621 ccgtaggtgc ccaggtggtg gccacgcagg tggtccagca gggatcgatg cggggatggg
    19681 gacgggggcg ggggtgaggt ggtcatcggt cggtcgcggt cccggtgatc gcgggcatcg
    19741 ccgaggcggt gcgggtgagt tcggtgacgg tgagggaggc gccgctcagc tcggcgctca
    19801 cgctcccgcg gacgaacacc agcgcgcgat ggcacacggc cgcgacctct tcgaaatcgg
    19861 tggagatgag caggacgccg aggccggagt cgagtgcgtc gtcgagcagc cggtggatgg
    19921 tggccttggc gccgacgtcc accccggccg tcggctcctc caggacgagc aggcgcaggt
    19981 gcccccggag ccatcggccg accatcacct tctgctggtt cccgccggac agggtggcga
    20041 tcggcacctc gctcctgcgg ggatgcaccg agaaccggtc gatgagggcg agggcctcgg
    20101 cgcgctcgcg acgggggctg atccagtgcc cggccggggc cccggacgcc cgcgggttcg
    20161 ccaggaagtt ctcccgcacg gtcaggtcgg cggcgcagcc ctcctcctgg cggttggccg
    20221 ccacgaagcc gacaccggcg tcgagcgcgg cgtgcaccga acgcggccgg tagggccgcc
    20281 cgtccagcag cacccggccc tccaggatcg gccgggcgcc ggccagggcg cggccgagct
    20341 ccatgtgacc ggcgccggtc aggcccacca tgccgaggat ctccccggcc cgcagctcca
    20401 gcccgacccg cccggtggac gcggtccgca ccccgtcgag gcgcagccgg ggcgcggctg
    20461 ctgcgggcgg tgcggcgggc acccggccgg cctgagcgga gccggccggt acgcggccca
    20521 cgatcgcccg caccagacgg tccgggctgt ggccggccag gggaccccgg tcgaccagcc
    20581 ggccgtcgcg caggacggcg aaggtgtcgg cgacctcgta cacctcgtcg aggcggtggc
    20641 tgacgtagag gatgccgtgc ccgcggtcgc gcagggcgtg caggacgtcg aagagccgtg
    20701 cgcagtcggc ggcggggagg gtggcggtcg gctcgtcgag gacgatgagc ccggcccggg
    20761 tggcgagggc gcgggcgatg gcgacgagcg agcgttcggc ggggccgagg tcgcggatcc
    20821 gggcatcggg ctccaggtgg ccggcgacga tccgcagggc ctcgtcgcag cgctgccggg
    20881 tccgccgcca ggagatcagt ccgcggtggc ggggatagcc ggtgcccagg gcgatgttct
    20941 cggccaccgt catccacggg accaggccga ggtcctggtg gatgaaggac atgctgcggg
    21001 ccgcggcgtg gctgccgagc ggatgcccgt ccaccgtcac gtggccctcg tcggcgtggt
    21061 ggaccccggc gagcaccttg atgagggtgg actttcccgc tccgttgggg ccgagcaggg
    21121 cgaggacact gccgcggtgg atgtcgaggt cgaccgaggc cagcgcgagc gtgccgccga
    21181 accgcttgct caggccgcgc atccggacga ggggcgcggc accggagcgc gggggtgggc
    21241 ccgcccaggt gtcgggagcg tcatgcacag acttctccgg gggtcggcct ccgagttctt
    21301 cccgacggta cggcgcactc tacggggacc tgacggtccg tccccggcat gtc
//
