LOCUS       NZ_CP020039            10375 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces sp. 3211 isolate 3 chromosome, complete genome.
ACCESSION   NZ_CP020039
VERSION     NZ_CP020039.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. 3211
  ORGANISM  Streptomyces sp. 3211
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8232231)
  AUTHORS   Heinsch,S.C., Hsu,S., Hansen,L., Kinkel,L. and Smanski,M.J.
  TITLE     Complete genomes of three Streptomyces isolated from disease
            suppressive soils
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8232231)
  AUTHORS   Heinsch,S.C., Hsu,S., Hansen,L., Kinkel,L. and Smanski,M.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-MAR-2017) Biotechnology Institute, University of
            Minnesota, 1479 Gortner Ave, Saint Paul, MN 55108, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 20-JAN-2017
            Assembly Method                   :: PacBio v. Jan-2016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: PacBio; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 03:18:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,254
            CDSs (total)                      :: 8,154
            Genes (coding)                    :: 7,815
            CDSs (with protein)               :: 7,815
            Genes (RNA)                       :: 100
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 340
            CDSs (without protein)            :: 339
            Pseudo Genes (ambiguous residues) :: 0 of 340
            Pseudo Genes (frameshifted)       :: 206 of 340
            Pseudo Genes (incomplete)         :: 257 of 340
            Pseudo Genes (internal stop)      :: 68 of 340
            Pseudo Genes (multiple problems)  :: 153 of 340
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:04:45
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 98054
            Orig. end                         :: 108429
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP020039.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Michael Smanski.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10375
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="2"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10375
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10375
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5375](-)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5375)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            135..725
                     /locus_tag="B4U39_RS00475"
     CDS             135..725
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005321958.1"
                     /locus_tag="B4U39_RS00475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_107469886.1"
                     /transl_table=11
                     /translation="MSALPVNRLSPSAVTDLSDLLATCFQQDALTRWMIPGEQRRAELL
                     PGFFRVFVELSAAFDGVLTSPDGDAVLLFLPPGAEPDEKALDAAFADVLGEYADAMRTI
                     AGLQEEAHPHGAPHYYVSFGAVRPGRQQSGLMSDLLGRVAARADAEGFGAYVEASSPGG
                     EATSRRVGFGLLGADIALPGGGPVLRPMWRDPR"
     gene            812..1357
                     /locus_tag="B4U39_RS00480"
     CDS             812..1357
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105932.1"
                     /locus_tag="B4U39_RS00480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6875 domain-containing protein"
                     /protein_id="WP_237296985.1"
                     /transl_table=11
                     /translation="MLMWSREFLVSSHPELGRTGPVCPYTQPSLRKELFHLAVPAAGCE
                     DLASAVDSLRTRHAVLSQRLTPEDRELLTILLVLPGFDPTDSVELDELQRKAKDEFVAE
                     GLMIGQFHPVCEEPGLYNEAFRPLRSPVPLLAVRKLLVFDLPFLVGDDAHMDHYLQRFA
                     PDLPSRIRDQLVSRVVAV"
     gene            complement(1460..2347)
                     /locus_tag="B4U39_RS00485"
     CDS             complement(1460..2347)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (48-139). E-value:
                     1.8e-09. Score: 29.5. Matches aSDomain:
                     nrpspksdomains_B4U39_RS00485_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018523330.1"
                     /locus_tag="B4U39_RS00485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_079403255.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 7.9e-12, bitscore:
                     45.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTQTTTQATTQATAQYPAPRPHTLNAGGITLSALLSLPPEGTP
                     VRSTILAIHGRGMRAAYWNSFAPLATALGHAVLAVDRPGYGDSADQLPDGQSLADQAET
                     LHAALKEHAAEYDIGAGILLLGHSDGGKVALHTAAADGGGTPLLGLDASGVGHHYNPRA
                     LHFPSTLGAGATKLNWGPLNLYPQGTFRASRTLLAPTPPRESAETLRWPGQYEALAPHV
                     RIPVRLTFAEHEAWWHLDAPTLTAMTSRLTAAPSVTVDHLAASGHNISLGHTAPAYHLR
                     VLTFLEDCLRTAPH"
     aSDomain        complement(1931..2203)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B4U39_RS00485_Abhydrolase_1.1"
                     /evalue="1.80E-09"
                     /label="B4U39_RS00485_Abhydrolase_1.1"
                     /locus_tag="B4U39_RS00485"
                     /protein_end="139"
                     /protein_start="48"
                     /score="29.5"
                     /tool="antismash"
                     /translation="TILAIHGRGMRAAYWNSFAPLATALGHAVLAVDRPGYGDSADQLP
                     DGQSLADQAETLHAALKEHAAEYDIGAGILLLGHSDGGKVALHTAA"
     gene            complement(2344..3066)
                     /locus_tag="B4U39_RS00490"
     CDS             complement(2344..3066)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005321952.1"
                     /locus_tag="B4U39_RS00490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="indole-3-glycerol phosphate synthase"
                     /protein_id="WP_079403256.1"
                     /transl_table=11
                     /translation="MTKDNRTAFPFLEALLTSPTPVVMEVKRRDAHGYDMLGGRTPAAI
                     VAAYESAGAPCVSVVTGRWFGGSPALLRDVAALTALPILQKDFITRKDQIRTAKELGAS
                     AVLLTAALLPASSMRTLVTECLLTGLTPFVEITQESELASVHHPEECVIAVNNKDIKTR
                     ERGAGDLGRSLDLLPAVTATGAACPVSASGIDSPQSAAALLDAGFGGLLVGTSLLRTGS
                     PAAWVDAMAGTRKGLALR"
     gene            complement(3063..3806)
                     /locus_tag="B4U39_RS00495"
     CDS             complement(3063..3806)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105934.1"
                     /locus_tag="B4U39_RS00495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="N-(5'-phosphoribosyl)anthranilate isomerase"
                     /protein_id="WP_237296534.1"
                     /transl_table=11
                     /translation="MSTTRPLSRTLLKVCGATTPQDIEAAAAAGADCVGLWHGVPGGPS
                     ELDRNGLAALAAAARSTGLLPVLVTFLSDAGELAAIAAHTGVGWIQLHAYQPPALVRAL
                     RQALPADVGIVKVLHVQENGGCVERPLIGAYDRAGTDLFLLDTATGDGRIGSTGAALDP
                     DRVTALLPRLTRPFLLAGGLTPTNRPAYEDVVHHPGFRGIDVDTAARTTTGGFGVPQIA
                     ALARAWRTDTHHTPRPDHPRLELSR"
     gene            complement(3803..4948)
                     /locus_tag="B4U39_RS00500"
     CDS             complement(3803..4948)
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105935.1"
                     /locus_tag="B4U39_RS00500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_079403257.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 6.9e-17, bitscore:
                     60.9, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.8e-25, bitscore:
                     87.8, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 5.1e-29, bitscore:
                     100.2, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRWNADQAELRDGLERWGDALSADHIELDEQSAFSEDKWKLVQK
                     TGILSLPFDEDHGGLGQSLLTTMYVLEGLGEYNRDAGLSFCITTSICSTGIPLQHFGTP
                     EQKDRYLHRICSGEAIGAHAITEAEGGSDAMAMATRAVRDGDDFVINGSKVFVSNGPIA
                     DVIVVYARTHPDGGPLGTTAFLVDRNTPGLSAGKPIKKMGLRTSPLSELFFDDVRVPKT
                     AVLGRVGGGFLVLDHVMKREILFSFIVNVGEMQHRLERCVEYARTRKSFGKAIGSYQTI
                     ANKIVDTKIQLETARKWLYDTGEKLEAGENVTTDLAISKIVTSESNLATSLTAVQIFGG
                     HGYMAEFGLEQDVRNAVGGTIYSGTNEIQYNRIASMLGLGK"
     gene            complement(5001..5375)
                     /locus_tag="B4U39_RS00505"
     CDS             complement(5001..5375)
                     /GO_function="GO:0033990 - ectoine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105936.1"
                     /locus_tag="B4U39_RS00505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine synthase"
                     /protein_id="WP_030390275.1"
                     /sec_met_domain="ectoine_synt (E-value: 1.9e-31, bitscore:
                     107.7, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRDIESVKTVEWGNGLSRRFLLAEDGLGYSLTDTTVLAGTKSR
                     LEYVNHLEACYCIEGSGEVIELDGTSHEIVPGRMYALDQHDAHYLVASPHEDLRLVCVF
                     SPALRGDEVHSLDAHSSSAY"
     misc_feature    5425..5439
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.05"
                     /tool="antismash"
     gene            complement(5446..6327)
                     /gene="trpA"
                     /locus_tag="B4U39_RS00510"
     CDS             complement(5446..6327)
                     /EC_number="4.2.1.20"
                     /GO_function="GO:0004834 - tryptophan synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0000162 - tryptophan biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="trpA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005321768.1"
                     /locus_tag="B4U39_RS00510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tryptophan synthase subunit alpha"
                     /protein_id="WP_079403258.1"
                     /transl_table=11
                     /translation="MPSPTAPAPTAGTDTAPTTTPAPAPFFTRRTPDGPPALALFLNAG
                     DPPLPVLRDLVLMLDQEGVDCLELAVPFPDSVTDGPVIRRSARRALQAGGADLDDVLAF
                     IADVRPHLKHLRIALLADWSHSLKHRDLATTTREIAAAGADGLLLHALPPRLRATHLET
                     AAAAGLPVVTTCYTQSPPATQAQAAAQASAYLYLVAHYGRSGTAPATGHAALARTVTAL
                     RAHTTSPIAVGFGVSTRQDVQAVGAAGADAAIIGSAAVAAVERARETGTDTVAAFRTFV
                     RQVLPEPPHRTA"
     gene            complement(6320..7369)
                     /locus_tag="B4U39_RS00515"
     CDS             complement(6320..7369)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005321935.1"
                     /locus_tag="B4U39_RS00515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_079403259.1"
                     /transl_table=11
                     /translation="MHDALTGLLEQRAPVGRETWRSWWDQLGDGGLDQAQVVALLASLT
                     SRLPDHQTLRHLLDSLAERRPAAPATTTAWEGTVNVVGTGGGPRTFNISTASAFVAAAA
                     GVKVVKTGSRAYTSSLGSVDLLERLGVRLTSSHAQTEDTLATHGIAFAGPFVYPTQLTR
                     LARTVAPHSMKPFGRFLNALGPFLADLPVTAQVTGVSAAAPLDTLRHLARTTTTRRIWL
                     TSNDTGADELLPFATNTIHGENSLTRIIRPGELTPGDGSFADLRPAADPTAAVAHFLSV
                     LAGDAGRVATRTVCLGAAALVVASGTRRDWLSAVSVAEDAIRSGAAHALAQRLATAPAP
                     ARTLAVTGA"
     gene            complement(7423..7680)
                     /locus_tag="B4U39_RS00520"
     CDS             complement(7423..7680)
                     /GO_function="GO:0000036 - acyl carrier activity [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PP-binding (18-62). E-value: 1.6e-07.
                     Score: 23.5. Matches aSDomain:
                     nrpspksdomains_B4U39_RS00520_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1147: putative acyl carrier protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005321933.1"
                     /locus_tag="B4U39_RS00520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl carrier protein"
                     /protein_id="WP_030390272.1"
                     /sec_met_domain="PP-binding (E-value: 2e-05, bitscore:
                     23.8, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding_2 (E-value: 0.0041, bitscore:
                     16.1, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNIDTIKNFVITEFLPGTTPAELATDHDLLNDGVIDSLGVLKLI
                     AWVEDRFELAIGDADLDPNNFRSVEAIDTFITASRRTAAA"
     aSDomain        complement(7495..7626)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B4U39_RS00520_PP-binding.1"
                     /evalue="1.60E-07"
                     /label="B4U39_RS00520_PP-binding.1"
                     /locus_tag="B4U39_RS00520"
                     /protein_end="62"
                     /protein_start="18"
                     /score="23.5"
                     /tool="antismash"
                     /translation="TTPAELATDHDLLNDGVIDSLGVLKLIAWVEDRFELAIGDADLD"
     gene            complement(7677..9308)
                     /locus_tag="B4U39_RS00525"
     CDS             complement(7677..9308)
                     /NRPS_PKS="Domain: AMP-binding (29-418). E-value: 8.9e-73.
                     Score: 237.1. Matches aSDomain:
                     nrpspksdomains_B4U39_RS00525_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105940.1"
                     /locus_tag="B4U39_RS00525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AMP-binding protein"
                     /protein_id="WP_079403260.1"
                     /sec_met_domain="AMP-binding (E-value: 4.5e-75, bitscore:
                     251.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPRTPRTTPAAAAGRTAPTVELGLLGGFLTQVRDRPHATALLF
                     NGQETTYRELYELAGRERDRLAHLDLAPGEPVGILADKSPAALALVLACLLARRPLLLP
                     SPALADTLLADLFAQAGCATVLAPDGQSARVTPNPEVTARPLPAAEAAEVAFMLTTSGS
                     TSLPKIVPLGLDAVDRFTRWAGHTFGITAGRTVLNYAPLNFDLCLLDVWTTLARGGRVV
                     LVDPALAAHGRHLRDLVLHHKVDIVQAVPMAFGLLQDAAAKTGDTFPGVEHVMFTGDAI
                     PERTLAALPQLFPHARIHNIYGCTETNDSFIHEVDTAPDAHPTTPVPIGRPLPGVRALI
                     IDPDTHTPVQGAGSGELFVSTPFQTRGYLDRTRHTDKFTGHPLGLDDRRWFRTGDLVRR
                     DDAGTLHLTGRTDFQVKVRGVAVNTAEIERILQEHPDVLEAGVAALPDPIAGKRLVAAV
                     RRAPGTTLTGLQLRTHCARHLPRAAVPHQLTVTEAPLPKTATGKVDRKQLDRLDRPAPT
                     TTGKTAGTTRSTTAPVATPLAEGIPS"
     CDS_motif       complement(8025..8087)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B4U39_RS00525_0003"
                     /evalue="7.90E-07"
                     /label="NRPS-A_a8"
                     /locus_tag="B4U39_RS00525"
                     /protein_end="428"
                     /protein_start="407"
                     /score="21.6"
                     /tool="antismash"
                     /translation="TGRTDFQVKVRGVAVNTAEIE"
     aSDomain        complement(8055..9221)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B4U39_RS00525_AMP-binding.1"
                     /evalue="8.90E-73"
                     /label="B4U39_RS00525_AMP-binding.1"
                     /locus_tag="B4U39_RS00525"
                     /protein_end="418"
                     /protein_start="29"
                     /score="237.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FLTQVRDRPHATALLFNGQETTYRELYELAGRERDRLAHLDLAPG
                     EPVGILADKSPAALALVLACLLARRPLLLPSPALADTLLADLFAQAGCATVLAPDGQSA
                     RVTPNPEVTARPLPAAEAAEVAFMLTTSGSTSLPKIVPLGLDAVDRFTRWAGHTFGITA
                     GRTVLNYAPLNFDLCLLDVWTTLARGGRVVLVDPALAAHGRHLRDLVLHHKVDIVQAVP
                     MAFGLLQDAAAKTGDTFPGVEHVMFTGDAIPERTLAALPQLFPHARIHNIYGCTETNDS
                     FIHEVDTAPDAHPTTPVPIGRPLPGVRALIIDPDTHTPVQGAGSGELFVSTPFQTRGYL
                     DRTRHTDKFTGHPLGLDDRRWFRTGDLVRRDDAGTLHLTGRTDFQVKVR"
     CDS_motif       complement(8181..8246)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B4U39_RS00525_0002"
                     /evalue="1.80E-03"
                     /label="NRPS-A_a6"
                     /locus_tag="B4U39_RS00525"
                     /protein_end="376"
                     /protein_start="354"
                     /score="10.7"
                     /tool="antismash"
                     /translation="GELFVSTPFQTRGYLDRTRHTD"
     CDS_motif       complement(8796..8846)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B4U39_RS00525_0001"
                     /evalue="4.00E-03"
                     /label="NRPS-A_a3"
                     /locus_tag="B4U39_RS00525"
                     /protein_end="171"
                     /protein_start="154"
                     /score="10.3"
                     /tool="antismash"
                     /translation="AFMLTTSGSTSLPKIVP"
     gene            complement(9305..10153)
                     /locus_tag="B4U39_RS00530"
     CDS             complement(9305..10153)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105941.1"
                     /locus_tag="B4U39_RS00530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MaoC/PaaZ C-terminal domain-containing protein"
                     /protein_id="WP_051779855.1"
                     /transl_table=11
                     /translation="MTTLSLPSPVRTLTVTEPEITDYRGAARRSLPTARPGQASPVHTF
                     VLAHTVAEQTVAALTAAEPGPVSVVHLGQDIRTLRPVRPGEQVTVTLDVLGIRKEARGA
                     RIALHIRLTGEDGPDPFAELVISALLVGATLLEPFGDISGGPAAPAPLGTGEPQSAVHA
                     LTTDWITTYAHASGDLNPIHLDEDAARAAGFDTVIAHGMSVVALAVEEATDRFAAGDSA
                     RVRGLGCRFSAPVPPGIPLEITLQPDAEARVVRFTCKTPKGAAVKSGWIEFADPAPGGP
                     R"
ORIGIN
        1 cgccgacgcc cgggccacac cctgaccccg ctcccccgct ccaccgctcc cccgttgctt
       61 cttcttccgt tccttgttcc cccgttccct gttccgccgt tcctccatcc cgtcacctga
      121 ccggaggcct tgccttgtct gccctgcccg tgaaccggct gagcccatcg gccgtcaccg
      181 atctgtccga cctcctcgcc acctgcttcc agcaggacgc cctgacccgc tggatgatcc
      241 ccggcgagca gcggcgcgcc gagctgctgc ccgggttctt ccgggtgttc gtggaactgt
      301 ccgccgcctt cgacggggtg ctcaccagcc cggacggcga cgcggtgctg ctgttcctgc
      361 cgcccggcgc cgagccggac gagaaggccc tggacgcggc gttcgccgat gtcctgggcg
      421 agtacgcgga tgcgatgcgc accatcgcgg gcctccagga ggaggcccat ccgcacggcg
      481 cgccgcacta ctacgtctcc ttcggggcgg tgcgccccgg ccggcagcag agcgggctga
      541 tgtccgacct gctgggccgg gtggcggccc gtgcggacgc cgaggggttc ggcgcctacg
      601 tggaggccag ctcccccggt ggtgaggcca ccagccggcg tgtcggtttc gggctgctgg
      661 gcgcggacat cgcgctgccc ggcggaggac ctgtactgcg acccatgtgg agggaccccc
      721 gatgagggga gacgatctga tccagtcgtg gaccgccggc gagatagccc gcggtgaggc
      781 tcctgcggag cacctcgggc cgttgctcca ggtgctgatg tggagccggg agttcctggt
      841 ctccagccat cccgagctgg ggcgcaccgg tccggtgtgc ccgtacacgc agccctcgct
      901 gcgcaaggag ctgttccatc tggcggtgcc ggcggcgggg tgcgaggacc tggcctcggc
      961 ggtggactcg ctgcgtaccc gtcatgcggt gctgtcgcag cggctgacgc cggaggaccg
     1021 tgagctgctg acgatcctgc tggtgctgcc ggggttcgat ccgacggatt cggtggagct
     1081 ggacgagttg cagcgcaagg cgaaggacga gttcgtggcg gaggggctga tgatcggtca
     1141 gttccatccg gtgtgcgagg agccgggcct gtacaacgag gcgttcaggc cgctgcgctc
     1201 tccggtgccg ttgttggcgg tccgcaagct gctggtgttc gatctgccgt tcctggtggg
     1261 cgacgacgcg cacatggacc actatttgca gcgtttcgcg ccggatctgc cgtcgcggat
     1321 ccgtgaccag ttggtgagcc gggtggtggc cgtctgaggc ggccggtgca cggctgtggc
     1381 cccggtggcg tctgccaccg gggcctcggt ctgtctgtcg gacggtcggt cggtctgtgg
     1441 tgcgggtggg gcggggggct cagtgcgggg cggtgcgcag gcagtcctcg aggaaggtca
     1501 ggacgcgcag gtggtaggcg ggggcggtgt ggccgaggct gatgttgtgg ccggaggcgg
     1561 ccaggtggtc gacggtgacg ctgggggccg ccgtcaggcg ggaggtcatc gcggtgaggg
     1621 tgggggcgtc caggtgccac caggcctcgt gttcggcgaa ggtgaggcgg acggggatgc
     1681 ggacgtgcgg ggccagggct tcgtactggc cgggccagcg cagggtttcc gcggactcgc
     1741 gcggtggtgt gggggcgagc agggtgcggc tggcccggaa ggtgccttgc gggtagaggt
     1801 tcagtgggcc ccagttgagt ttggtggcgc cggcgcccag ggtggagggg aagtgcaggg
     1861 cccgggggtt gtagtggtgg ccgacgccgg aggcgtccag gcccagcaag ggggtgccgc
     1921 cgccgtcggc ggctgcggtg tggagggcga ccttgccgcc gtcggagtgg cccagcagga
     1981 ggatcccggc gccgatgtcg tactcggcgg cgtgttcctt gagggcggcg tggagggttt
     2041 cggcctggtc ggcgaggctc tggccgtcgg gcagctggtc ggcggagtcg ccgtagccgg
     2101 ggcggtcgac ggccaggacg gcgtggccca gggcggtggc gaggggggcg aaggagttcc
     2161 agtaggcggc gcgcatgccg cggccgtgga tggccaggat cgtggagcgg accggtgtgc
     2221 cctcgggggg caggctcagg agggcggaga gggtgatgcc gcccgcgttg agggtgtggg
     2281 gccggggggc ggggtactgg gccgtcgcct gtgtcgtcgc ctgtgtcgtc gtctgtgtcg
     2341 tcgtcatcgc agggccagcc ccttccgggt gcccgccatg gcgtccaccc aggccgcggg
     2401 cgatccggtg cgcagcagtg aggtgcccac gaggaggccg ccgaagccgg cgtccaggag
     2461 tgcggcggcg ctctgggggc tgtcgatgcc gctggcgctg acggggcagg cggcgccggt
     2521 ggcggtgacg gcgggcagca ggtccaggga gcggccgagg tctccggcgc cgcgttcgcg
     2581 ggtcttgatg tccttgttgt tgacggcgat gacgcattcc tcggggtggt ggaccgaggc
     2641 gagttcgctt tcctgggtga tctcgacgaa gggggtgagg ccggtgagca ggcattcggt
     2701 gaccagggtc cgcatgctcg acgccggcag cagtgccgcg gtgagcagga cggcggaggc
     2761 gccgagctcc ttggcggtgc ggatctggtc cttgcgggtg atgaagtcct tctggaggat
     2821 cggcagtgcg gtcagtgcgg ccacgtcgcg cagcagggcg ggtgagccgc cgaaccagcg
     2881 gcccgtgacg accgagacgc agggtgcgcc cgcgctctcg taggcggcga cgatggcggc
     2941 gggggttctg ccgccgagca tgtcgtagcc gtgggcgtcg cgtcgtttca cctccatcac
     3001 cacgggggtc ggggaggtca ggagggcctc gagaaaaggg aaggcggtcc ggttgtcctt
     3061 cgtcatcgcg acagctccag tcgggggtgg tcggggcggg gggtgtggtg ggtgtcggtg
     3121 cgccaggcgc gggccagggc ggcgatctgc gggacgccga agccgccggt ggtggtgcgg
     3181 gcggcggtgt cgacgtcgat gccgcggaat ccggggtggt ggacgacgtc ctcgtaggcg
     3241 ggtcggttgg tgggggtcag gccgccggcg aggaggaagg ggcgggtcag gcggggcagc
     3301 agggcggtga cgcggtcggg gtccagggcg gcgccggtgc tgccgatgcg gccgtcgccg
     3361 gtggcggtgt cgaggaggaa gaggtcggtg ccggcccggt cgtaggcgcc gatcaggggg
     3421 cgttccacgc agccgccgtt ctcctggacg tgcagcacct tgacgatgcc gacgtcggcg
     3481 gggagtgcct ggcgcagggc ccggacgagg gcggggggct ggtaggcgtg gagctggatc
     3541 cagccgacgc cggtgtgcgc cgcgatcgcg gcgagttcac cggcgtcgga caggaacgtc
     3601 accaggaccg gcaggaggcc ggtggagcgg gccgccgccg cgagggcggc gagcccgttc
     3661 cggtccagtt cgctggggcc gccgggtacg ccgtgccaga ggccgacgca gtcggccccg
     3721 gcggccgccg cggcctcgat gtcctgcggg gtggtggccc cgcagacctt cagcagggtc
     3781 cgggacaggg ggcgggtggt gctcactttc ccagtcccag catcgaggcg atgcggttgt
     3841 actggatttc gttggtgccg gagtagatcg tgccgccgac cgcgttgcgc acgtcctgct
     3901 ccaggccgaa ctcggccatg tagccgtggc cgccgaagat ctgtacggcg gtgaggctgg
     3961 tggcgaggtt ggactcgctg gtgacgattt tggagatggc gaggtcggtg gtgacgttct
     4021 cgccggcctc cagtttttcg ccggtgtcgt agagccactt gcgggcggtc tccagctgga
     4081 tcttcgtgtc gacgatcttg ttggcgatcg tctggtacga accgatcgcc tttccgaacg
     4141 acttgcgtgt cctggcgtat tcgacgcagc gttccagccg gtgctgcatc tcccccacgt
     4201 tgacgatgaa ggagaagagg atctcccgtt tcatgacgtg gtccaggacc aggaagcctc
     4261 ctccgacgcg gccgaggacc gcggttttcg gtacgcgtac gtcgtcgaag aacagctcgc
     4321 tgagcggtga ggtgcgcagg cccatcttct tgatgggttt gccggcgctg aggccggggg
     4381 tgttgcggtc gacgaggaag gcggtggtgc cgagcgggcc gccgtccggg tgggtgcggg
     4441 cgtagacgac gatcacgtcg gcgatggggc cgttgctgac gaagaccttg ctgccgttga
     4501 tgacgaagtc gtcgccgtcg cgtacggccc tggtggccat ggccatggcg tcggagccgc
     4561 cttcggcctc ggtgatggcg tgggcgccga tcgcctcgcc cgagcagatg cggtgcaggt
     4621 agcggtcctt ctgctcgggg gtgccgaagt gctggagggg gatgccggtg gagcagatgg
     4681 aggtggtgat gcagaagctg aggcccgcgt cgcggttgta ctcgccgagg ccctccagta
     4741 cgtacatcgt ggtcaggagt gactgtccga ggcctccgtg gtcctcgtcg aagggcagtg
     4801 agaggatgcc ggtcttctgg acgagcttcc acttgtcctc ggagaaggcg gactgctcgt
     4861 cgagttcgat gtggtctgcg ctgagtgcgt ctccccaccg ctccaggccg tcgcgcagtt
     4921 ctgcctggtc ggcgttccaa cggatcacga gggacccctt tgattcggtg atggtgagga
     4981 tgggtgctgc atcgggtgcc tcagtaggcg gaggagctgt gggcgtcgag gctgtggacc
     5041 tcgtcgccgc gcagggcggg tgagaagacg cagaccaggc gcaggtcctc gtgggggctg
     5101 gcgacgaggt agtgggcgtc gtgctggtcg agtgcgtaca tgcggcccgg gacgatctcg
     5161 tgggaggtgc cgtcgagttc gatgacctcg ccggagccct cgatgcagta gcaggcctcg
     5221 aggtggttga cgtactccag gcgggacttg gtgccggcca ggacggtggt gtcggtgagc
     5281 gagtagccca ggccgtcctc ggcgaggagg aagcggcggc tgaggccgtt gccccactcg
     5341 acggtcttca cggactcgat gtcgcgaacg atcatggcag tctcctggtg tgagggtggt
     5401 gcacgggatg gttcggatga ggggtggaga tcgtgttccc gccggtcagg cggttcggtg
     5461 cggtggttcg ggcaggacct gtcggacgaa ggtgcggaag gcggcgaccg tgtcggtgcc
     5521 ggtttcccgg gctcgttcga cggcggcgac cgcggcggag ccgatgatcg cggcgtcggc
     5581 gccggcggcg ccgacggcct ggacgtcctg ccgtgtgctg accccgaagc cgacggcgat
     5641 cggggacgtc gtgtgggccc gcagggcggt gaccgttcgg gccagtgcgg cgtggccggt
     5701 ggcgggtgcg gttccgctgc gtccgtagtg ggcgacgagg tagaggtagg cggaggcctg
     5761 tgcggcggcc tgggcctggg tggcgggcgg gctctgggtg tagcaggtgg tgacgacggg
     5821 caggccggcg gcggcggccg tttccaggtg ggtggcgcgc agccgtgggg gcagggcgtg
     5881 caggaggagt ccgtcggcgc cggcggcggc gatctcgcgg gtggtggtgg ccaggtcccg
     5941 gtgtttgagg gagtggctcc agtcggcgag cagggcgatc cgcaggtgct tgaggtgggg
     6001 ccgtacgtcg gcgatgaagg cgagtacgtc gtccaggtcg gctccgccgg cttgcagtgc
     6061 ccggcgggcg gagcggcgga tgacggggcc gtcggtgacc gagtcgggga aggggacggc
     6121 cagttcgagg cagtcgacgc cctcttgatc gagcatgagg accaggtcgc gcaggacggg
     6181 caggggcggg tcgccggcgt tgaggaagag ggcgagtgcg gggggtccgt ccggggtgcg
     6241 gcgggtgaag aagggggcgg gggccggtgt ggtggtcggg gcggtgtccg tccccgccgt
     6301 gggggccggc gctgtggggc taggcaccgg tcaccgccag ggtgcgggcg ggggccgggg
     6361 cggtggcgag gcgctgggcg agggcgtggg cggcgccgga gcggatggcg tcctcggcga
     6421 cggagacggc ggagagccag tcgcggcggg tgccggaggc cacgaccagg gcggcggcgc
     6481 cgaggcagac ggtgcgggtg gcgacgcggc cggcgtcgcc ggccaggacg gagaggaagt
     6541 gggcgacggc ggcggtgggg tcggcggctg gccgcaggtc ggcgaaggag ccgtcgccgg
     6601 gggtgagttc gccgggtcgg atgatgcggg tcagggagtt ctcgccgtgg atggtgttgg
     6661 tggcgaaggg caggagttcg tccgcgccgg tgtcgttgga ggtgagccag atgcggcggg
     6721 tggtggtggt ccgggcgagg tggcgcaggg tgtcgagggg ggcggccgcc gagaccccgg
     6781 tgacctgggc ggtcaccggg aggtcggcga ggaaggggcc cagggcgttc aggaaccggc
     6841 cgaagggttt catgctgtgg ggggccacgg tccgtgccag ccgggtcagt tgggtggggt
     6901 agacgaacgg gccggcgaag gcgatgccgt gggtggcgag ggtgtcctcg gtctgggcgt
     6961 gggaggaggt gagacggacg ccgagccgct ccagcaggtc gacggatccc agggagctgg
     7021 tgtaggcgcg ggagccggtt ttgacgacct tgactccggc tgcggcggcg acgaaggccg
     7081 aggcggtgga gatgttgaag gtccgggggc cgccgccggt gccgacgacg ttcacggtgc
     7141 cttcccaggc ggtggtcgtc gccggggctg ccgggcggcg ctcggcgagc gagtccagca
     7201 ggtggcgcag ggtctggtgg tcggggagcc ggctggtcag ggaggccagc agggcgacga
     7261 cctgggcctg gtccaggccg ccgtcgccga gctggtccca ccaggaccgc caggtctcgc
     7321 ggccgaccgg ggctcgctgt tccagcaggc cggtgagtgc gtcgtgcacg gtcggtctcc
     7381 gtctcgtctg cgtcgggtcg gggtcggtcg gtggtgggcg ggtcaggcgg ccgcggtgcg
     7441 ccgggaggcg gtgatgaagg tgtcgatggc ctcgacgctg cggaagttgt tggggtccag
     7501 gtcggcgtcg ccgatggcga gctcgaagcg gtcctcgacc caggcgatga gcttgaggac
     7561 gcccaggctg tcgatgaccc cgtcgttgag gaggtcgtgg tcggtggcga gttcggcggg
     7621 ggtggtgccc gggaggaact cggtgatgac gaagttcttg atggtgtcga tgttgctcat
     7681 gacgggattc cttcggcgag aggtgtggcg acgggtgcgg tcgtggatcg ggtggtgccg
     7741 gcggttttgc cggtggtcgt gggggccggc cggtcgagtc ggtcgagttg cttgcggtcg
     7801 acttttccgg tggcggtctt gggcaggggc gcttcggtga cggtgagttg gtgcgggacg
     7861 gcggccctgg gcaggtggcg ggcgcagtgg gtgcgcagtt gcaggccggt cagggtggtg
     7921 ccgggggcgc gccggaccgc ggcgaccagt cgtttgccgg cgatggggtc gggcagggcc
     7981 gcgacgccgg cttccaggac gtcggggtgt tcctgcagga tccgttcgat ctcggcggtg
     8041 ttgacggcga cgccgcggac cttgacctgg aagtcggtgc gtccggtcag gtgcagggtg
     8101 ccggcgtcgt cgcgtcggac gaggtcgccg gtgcggaacc agcggcggtc gtccaggccc
     8161 agggggtggc cggtgaactt gtcggtgtgg cgggtgcggt cgaggtagcc gcgggtctgg
     8221 aagggcgtgg agacgaagag ttctccgctg ccggctccct ggacgggggt gtgggtgtcg
     8281 gggtcgatga tcagggcgcg tacgccgggc agcgggcggc cgatggggac gggtgtcgtg
     8341 gggtgggcgt ccggtgcggt gtcgacctcg tggatgaagc tgtcgttggt ctcggtgcat
     8401 ccgtagatgt tgtggatgcg ggcgtggggg aagagctggg gcagggcggc gagggtgcgc
     8461 tcggggatgg cgtcgccggt gaacatgacg tgttcgacgc cggggaaggt gtcgccggtc
     8521 ttggcggccg cgtcctggag gagtccgaag gccatgggga cggcctggac gatgtcgacc
     8581 ttgtggtgca ggaccaggtc gcgcaggtgg cggccgtggg cggccagggc ggggtcgacg
     8641 aggaccacgc gtccgccgcg ggcgagggtg gtccacacgt cgaggaggca gaggtcgaag
     8701 ttgagggggg cgtagttcag gacggtgcgg cctgctgtga tgccgaaggt gtggccggcc
     8761 cagcgggtga accggtcgac ggcgtccagg cccagcggga cgatcttggg gaggctggtg
     8821 gatccggagg tggtgagcat gaaggccact tcggcggcct cggcggccgg gagcggccgg
     8881 gcggtgacct cggggttggg ggtgacgcgg gcgctctgcc cgtcgggggc caggacggtg
     8941 gcgcagccgg cctgggcgaa gaggtcggcc aggagggtgt cggcgagggc cggggagggg
     9001 agcagcaggg ggcgtcgggc gagcaggcag gccaggacga gggcgagggc ggcgggtgac
     9061 ttgtcggcga ggatgccgac cggttcgccg ggggcgaggt ccaggtgtgc gagccggtcg
     9121 cgttcgcggc cggcgagctc gtacagctcg cggtaggtgg tctcctggcc gttgaacagc
     9181 agggcggtgg cgtgggggcg gtcgcggacc tgggtcagga agccgccgag gaggccgagt
     9241 tcgacggtgg gggcggtgcg gccggcggct gctgcggggg tggtgcgggg ggtgcggggt
     9301 gcggtcatcg ggggcctccc ggtgcggggt cggcgaactc gatccagccg gacttcacgg
     9361 cggccccctt gggggtcttg caggtgaagc ggacgacgcg ggcctcggcg tcgggctgga
     9421 gggtgatctc cagggggatg ccggggggta cgggggcgga gaagcggcag cccaggccgc
     9481 ggacgcgggc ggagtcgccg gcggcgaagc ggtcggtggc ctcctcgacg gcgagggcga
     9541 ccacgctcat gccgtgggcg atgacggtgt cgaagccggc ggcgcgggcg gcgtcctcgt
     9601 cgaggtggat ggggttgagg tcgccggagg cgtgggcgta ggtggtgatc cagtcggtgg
     9661 tcagggcgtg gaccgcgctc tgcggctcgc cggtcccgag cggggcgggg gcggcggggc
     9721 cgcccgagat gtcgccgaag ggctccagga gggtcgcgcc gaccagcagg gcggagatga
     9781 ccagttccgc gaaggggtcg gggccgtcct cgccggtcag gcggatgtgc agggcgatgc
     9841 gggcgccgcg ggcctccttg cggatgccga ggacgtccag ggtcacggtg acctgctcgc
     9901 cggggcggac cgggcgcagg gtgcggatgt cctggccgag gtggacgacg gagacggggc
     9961 ccggttcggc cgcggtcagc gcggcgacgg tctgttcggc cacggtgtgg gcgaggacga
    10021 aggtgtggac gggggatgcc tggccggggc gggcggtggg cagggagcgg cgggcggcgc
    10081 cgcggtagtc ggtgatctcg ggttcggtga cggtgagcgt gcggaccggg gagggcaggg
    10141 agagggtcgt cataccggcg tcaccaccac ggaggagttg tggccgccga atccgaagga
    10201 gttcgtgatc gcgggtccgg ggcgcacggc gcggggtgcg ccgtggacga cgtcgatgtc
    10261 cattcctggc tcctgctgtt cgtggttggc ggtgggtggc acctcgcagt ggcgcatggc
    10321 ctgcacggtg gcgatgagtt cgacggcgcc ggcggcgccg atgaggtggc cgatg
//
