GCF_002019735.1 - 7 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_KV917378.1 (Salipaludibacillus agaradhaerens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	ectoine	577,289	587,678	Medium	ectoine	other:other
Region 2	terpene-precursor	892,675	913,559
Region 3	lanthipeptide-class-ii	1,496,558	1,525,162
Region 4	phosphonate	1,960,718	1,979,722
Region 5	NRP-metallophore,NRPS	2,386,034	2,437,900	High	bacillibactin/bacillibactin E/bacillibactin F	NRPS:Type I
Region 6	opine-like-metallophore	2,528,639	2,550,764	High	bacillopaline	other:other
Region 7	terpene	3,833,435	3,854,256

NZ_KV917378.1 - Region 1 - ectoine

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Location: 577,289 - 587,678 nt. (total: 10,390 nt) Show pHMM detection rules used

ectoine: ectoine_synt

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

BK581_RS02690: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Hydrolases: back translocase

BK581_RS02700: GTP-binding protein LepA

smcogs: SMCOG1190: GTP-binding protein LepA

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000858.3	0.73	other (other)	ectoine	Methylobacter marinus
BGC0000856.3	0.72	other (other)	ectoine	Methylophaga thalassica
BGC0000852.5	0.72	other (other)	ectoine	Sporosarcina pasteurii
BGC0000855.3	0.67	other (other)	ectoine	Methylomicrobium kenyense
BGC0000859.3	0.67	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0002052.3	0.62	other (ectoine)	ectoine	Streptomyces sp.
BGC0000853.3	0.62	other (other)	ectoine	Streptomyces anulatus
BGC0000857.3	0.61	other (other)	ectoine	Methylophaga alcalica
BGC0000860.3	0.59	other (other)	ectoine	Methylarcula marina
BGC0000854.3	0.56	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000858.3	0.73	other (other)	ectoine	Methylobacter marinus
BGC0000856.3	0.72	other (other)	ectoine	Methylophaga thalassica
BGC0000852.5	0.72	other (other)	ectoine	Sporosarcina pasteurii
BGC0000855.3	0.67	other (other)	ectoine	Methylomicrobium kenyense
BGC0000859.3	0.67	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0002052.3	0.62	other (ectoine)	ectoine	Streptomyces sp.
BGC0000853.3	0.62	other (other)	ectoine	Streptomyces anulatus
BGC0000857.3	0.61	other (other)	ectoine	Methylophaga alcalica
BGC0000860.3	0.59	other (other)	ectoine	Methylarcula marina
BGC0000854.3	0.56	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.15 out of 20.97

Confidence: medium

Additional weak hits (4):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 22.93 out of 30.97

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 25.58 out of 30.98

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.30 out of 26.85

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A

NZ_KV917378.1 - Region 2 - terpene-precursor

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Location: 892,675 - 913,559 nt. (total: 20,885 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

BK581_RS04290: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

BK581_RS04250: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

BK581_RS04260: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000668.5	0.37	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000668.5	0.37	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

BK581_RS04260: PT_FPPS_like

Domain 1 (33 - 293): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.86 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.31 out of 26.06

Confidence: medium

Additional weak hits (2):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.28 out of 30.25

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.18 out of 25.75

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes

NZ_KV917378.1 - Region 3 - lanthipeptide-class-ii

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Location: 1,496,558 - 1,525,162 nt. (total: 28,605 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

BK581_RS07305: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

BK581_RS07315: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Ligases: synthase

BK581_RS07275: cobalamin synthesis protein/P47K family protein

smcogs: SMCOG1178: cobalamin synthesis protein/P47K family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001391.3	0.56	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000552.3	0.55	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0000520.5	0.55	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000525.5	0.54	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000516.4	0.54	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0001210.5	0.53	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000497.3	0.53	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000539.5	0.52	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0001311.5	0.52	ribosomal	flavecins	Ruminococcus flavefaciens FD-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001391.3	0.56	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000552.3	0.55	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0000520.5	0.55	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000525.5	0.54	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000516.4	0.54	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0001210.5	0.53	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000497.3	0.53	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000539.5	0.52	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0001311.5	0.52	ribosomal	flavecins	Ruminococcus flavefaciens FD-1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for BK581_RS07305

BK581_RS20095

Leader:

MKRVNGIEEISETELKNLAGG

Core:

SNDNQPATWTITIPISAAACPTTQCASVVKPCNG

Core with dehydrations:

DhaNDNQPADhbWDhbIDhbIPIDhaAAACysPDhbDhbQCysADhaVVKPCysNG

antiSMASH-DB 4.0 matches for BK581_RS20095

100.0%

NZ_KV917378.1and 1 other:

NZ_KV917378.1 Lanthipeptides: BK581_RS20095_lanthipeptide

Lanthipeptides: BK581_RS20095_lanthipeptide

SNDNQPATWTITIPISAAACPTTQCASVVKPCNG

65.8%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide

Lanthipeptides: BM124_RS15255_lanthipeptide

NDNQPA---TWTITIPISAAACPTTQCASVVKPCN

+D QPA T T+TIPISA CPTT+CASVVKPCN

SDQQPASHPTTTVTIPISAWGCPTTKCASVVKPCN

64.7%

NZ_CP063142.1and 5 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide

Lanthipeptides: HPB58_RS21455_lanthipeptide

NQPATWTITIPISAAACPTTQCASVVKPCN

+ A WT+TIPIS AACPTTQCAS+V PCN

EERAIWTVTIPISLAACPTTQCASIVSPCN

with 67 more sequence matches

Only the first 10 are displayed here.

63.2%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide

Lanthipeptides: G475_RS0114655_lanthipeptide

NDNQPA---TWTITIPISAAACPTTQCASVVKPCN

+D QPA T T+TIPISA CPTT+CASVV+PCN

SDQQPASHPTTTVTIPISAWGCPTTKCASVVEPCN

61.8%

NZ_BQME02000001.1and 3 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide

Lanthipeptides: MFF31_RS04090_lanthipeptide

WTITIPISAAACPTTQCASVVKPCNG

WTI IPIS AACPTT+CAS+V PCNG

WTIIIPISLAACPTTRCASIVSPCNG

61.8%

NZ_CP101913.1and 1 other:

NZ_CP101913.1 Lanthipeptides: NP440_RS09140_lanthipeptide

Lanthipeptides: NP440_RS09140_lanthipeptide

ATWTITIPISAAACPTTQCASVVKPCN

T T+TIPISAA CPTTQCAS+V+PCN

GTPTVTIPISAAICPTTQCASIVRPCN

58.8%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide

Lanthipeptides: MFF31_RS04085_lanthipeptide

WTITIPISAAACPTTQCASVVKPCNG

WTI IPIS AACPTT+CAS+V CNG

WTIIIPISLAACPTTRCASIVSSCNG

52.9%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide

Lanthipeptides: KJS43_RS18000_lanthipeptide

IPISAAACPTTQCASVVKPCNG

IP+S A CPTT+CASVVKPCNG

IPVSLAICPTTKCASVVKPCNG

51.4%

NZ_JAMDLZ010000027.1:

Lanthipeptides: M5W82_RS15520_lanthipeptide

TITIPISAAACPTTQCASVVKPCNG

T+TIPIS A CPTT+CAS+V PC G

TVTIPISLAGCPTTKCASIVSPCKG

50.0%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide

Lanthipeptides: B2C77_RS21505_lanthipeptide

IPISAAACPTTQCASVVKPCN

IP+S A CPTT+CASVVKPCN

IPVSLAICPTTKCASVVKPCN

44.1%

NZ_CP040417.1and 7 others:

NZ_CP040417.1 Lanthipeptides: FE328_RS09035_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptide

Lanthipeptides: FE328_RS09035_lanthipeptide

WTITIPISAAACPTTQCASVVKPCN

WT +PIS A CP+T+CAS+ +PCN

WTSLVPISLAICPSTKCASITRPCN

44.1%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

IPISAAACPTTQCASVVKPCNG

IP+S A CPTT+CAS+V+ CNG

IPVSLAICPTTRCASIVESCNG

44.1%

NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

DNQPATWTITIPISAAACPTTQCASVVKPC

D P T IP+S A CPTT C S PC

DTHPTTI---IPVSLAVCPTTTCRSFSSPC

MIBiG 4.0 matches for BK581_RS20095

24.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

ITIPISAAACPTTQCAS

+ + +SAA CPTT+C S

VAVGVSAAFCPTTKCTS

17.6%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

CPTTQCAS

CPTT+C S

CPTTKCTS

BK581_RS07320

Leader:

MEELYAIAGNVAEEMEEISLNSVSGG

Core:

ADVQGISQGNDGKYCTITWECSICPTHTCWC

Core with dehydrations:

ADVQGIDhaQGNDGKYCysDhbIDhbWECysDhaICysPDhbHDhbCysWCys

antiSMASH-DB 4.0 matches for BK581_RS07320

100.0%

NZ_KV917378.1and 1 other:

NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide

Lanthipeptides: BK581_RS07320_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTCWC

87.5%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide

Lanthipeptides: KJS43_RS18005_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTCWC

A+ GISQGNDGKYCTITWECSICPTHTCWC

AEPMGISQGNDGKYCTITWECSICPTHTCWC

83.9%

NZ_CP063142.1and 10 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptideNZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide

Lanthipeptides: HPB58_RS21475_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTCWC

A+ +GISQGNDG CTITWECSICPTHTCWC

AEQRGISQGNDGHQCTITWECSICPTHTCWC

with 92 more sequence matches

Only the first 10 are displayed here.

81.2%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide

Lanthipeptides: B2C77_RS00795_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTCWC

A+ GISQGNDGK+CT+TWECSICPTHTCWC

AEPMGISQGNDGKWCTVTWECSICPTHTCWC

78.1%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide

Lanthipeptides: MFF31_RS04105_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTC-WC

A+ +GISQGNDGKYCT+TWECS+CPT TC WC

AEQRGISQGNDGKYCTLTWECSVCPTLTCFWC

78.1%

NZ_CP101913.1and 1 other:

NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide

Lanthipeptides: NP440_RS09135_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTCWC

A+ GIS+ NDGKYCT+TWECSICPTHTCWC

AEPMGISEDNDGKYCTLTWECSICPTHTCWC

77.4%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide

Lanthipeptides: WH45_RS23330_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTCWC

A+VQG+SQGNDGK CT+TWEC +CPTHTC+C

AEVQGLSQGNDGKVCTLTWECGLCPTHTCFC

75.8%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide

Lanthipeptides: BM124_RS15270_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTCWC

A+ +GISQGNDG YCTITWEC +CPTHTCWC

AEPRGISQGNDGDYCTITWECGMCPTHTCWC

69.7%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide

Lanthipeptides: G475_RS0114640_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTCWC

+ +G+SQGNDG YCTITWEC +CPTHTCWC

VETRGLSQGNDGDYCTITWECGMCPTHTCWC

65.6%

NZ_JAMDLZ010000027.1:

Lanthipeptides: M5W82_RS15515_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTCW

+ + IS+GNDGK+CT+TWECSICPT TCW

VETKKISKGNDGKWCTLTWECSICPTKTCW

63.2%

NC_023073.1and 73 others:

NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide

Lanthipeptides: U722_RS06170_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTCWC

A+ +GISQGNDGK CT+TWEC +CPTHTCWC

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

60.5%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide

Lanthipeptides: J7E20_RS10220_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTCWC

A+ +GISQGNDGK CT+TWEC +CPTHTC+C

AEQRGISQGNDGKLCTLTWECGLCPTHTCFC

50.0%

NZ_CP040417.1and 7 others:

NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide

Lanthipeptides: FE328_RS09040_lanthipeptide

VQGISQGNDGKYCTITWECSICPTHTCW

++ +S+GN GK CT+TWEC ICP+HTC+

IRKLSKGNTGKVCTLTWECGICPSHTCF

MIBiG 4.0 matches for BK581_RS07320

29.0%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

GNDGKYCTITWEC

GN G YCT+T EC

GNKGAYCTLTVEC

25.8%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

GNDGKYCTITWEC

GN+G +CT+T EC

GNNGGWCTLTKEC

10.3%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTITWEC

CT++ EC

CTLSKEC

allorf_1499673_1499759

Leader:

MKLERVERCVGG

Core:

NSYTTCNIFLGMFLLA

Core with dehydrations:

NDhaYDhbDhbCysNIFLGMFLLA

antiSMASH-DB 4.0 matches for allorf_1499673_1499759

100.0%

NZ_KV917378.1:

Lanthipeptides: allorf_1499673_1499759_lanthipeptide

NSYTTCNIFLGMFLLA

allorf_1502358_1502453

Leader:

MGFYLKSRIKCLSTVGGLRTVIYF

Core:

TCSATLI

Core with dehydrations:

DhbCysDhaADhbLI

antiSMASH-DB 4.0 matches for allorf_1502358_1502453

100.0%

NZ_KV917378.1and 1 other:

NZ_KV917378.1 Lanthipeptides: allorf_1502358_1502453_lanthipeptide

Lanthipeptides: allorf_1502358_1502453_lanthipeptide

TCSATLI

allorf_1515636_1515734

Leader:

MSCFCGILLLFFVVHQIIEGEVGGA

Core:

RFYFRCS

Core with dehydrations:

RFYFRCysDha

antiSMASH-DB 4.0 matches for allorf_1515636_1515734

100.0%

NZ_KV917378.1and 1 other:

NZ_KV917378.1 Lanthipeptides: allorf_1515636_1515734_lanthipeptide

Lanthipeptides: allorf_1515636_1515734_lanthipeptide

RFYFRCS

allorf_1515683_1515811

Leader:

MNLPLRRVNDFLAYLVYTMVNITAA

Core:

RCRVSAVSCCYFLSFIK

Core with dehydrations:

RCysRVDhaAVDhaCysCysYFLDhaFIK

antiSMASH-DB 4.0 matches for allorf_1515683_1515811

100.0%

NZ_KV917378.1and 1 other:

NZ_KV917378.1 Lanthipeptides: allorf_1515683_1515811_lanthipeptide

Lanthipeptides: allorf_1515683_1515811_lanthipeptide

RCRVSAVSCCYFLSFIK

26.3%

NZ_CM000719.1:

Lanthipeptides: allorf_5300946_5301086_lanthipeptide

SCCYFLSFIK

C+FLSF+

GICFFLSFLP

Lanthipeptide(s) for BK581_RS07315

BK581_RS20095

Leader:

MKRVNGIEEISETELKNLAGG

Core:

SNDNQPATWTITIPISAAACPTTQCASVVKPCNG

Core with dehydrations:

DhaNDNQPADhbWDhbIDhbIPIDhaAAACysPDhbDhbQCysADhaVVKPCysNG

antiSMASH-DB 4.0 matches for BK581_RS20095

100.0%

NZ_KV917378.1and 1 other:

NZ_KV917378.1 Lanthipeptides: BK581_RS20095_lanthipeptide

Lanthipeptides: BK581_RS20095_lanthipeptide

SNDNQPATWTITIPISAAACPTTQCASVVKPCNG

65.8%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide

Lanthipeptides: BM124_RS15255_lanthipeptide

NDNQPA---TWTITIPISAAACPTTQCASVVKPCN

+D QPA T T+TIPISA CPTT+CASVVKPCN

SDQQPASHPTTTVTIPISAWGCPTTKCASVVKPCN

64.7%

NZ_CP063142.1and 5 others:

Lanthipeptides: HPB58_RS21455_lanthipeptide

NQPATWTITIPISAAACPTTQCASVVKPCN

+ A WT+TIPIS AACPTTQCAS+V PCN

EERAIWTVTIPISLAACPTTQCASIVSPCN

with 67 more sequence matches

Only the first 10 are displayed here.

63.2%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide

Lanthipeptides: G475_RS0114655_lanthipeptide

NDNQPA---TWTITIPISAAACPTTQCASVVKPCN

+D QPA T T+TIPISA CPTT+CASVV+PCN

SDQQPASHPTTTVTIPISAWGCPTTKCASVVEPCN

61.8%

NZ_BQME02000001.1and 3 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide

Lanthipeptides: MFF31_RS04090_lanthipeptide

WTITIPISAAACPTTQCASVVKPCNG

WTI IPIS AACPTT+CAS+V PCNG

WTIIIPISLAACPTTRCASIVSPCNG

61.8%

NZ_CP101913.1and 1 other:

NZ_CP101913.1 Lanthipeptides: NP440_RS09140_lanthipeptide

Lanthipeptides: NP440_RS09140_lanthipeptide

ATWTITIPISAAACPTTQCASVVKPCN

T T+TIPISAA CPTTQCAS+V+PCN

GTPTVTIPISAAICPTTQCASIVRPCN

58.8%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide

Lanthipeptides: MFF31_RS04085_lanthipeptide

WTITIPISAAACPTTQCASVVKPCNG

WTI IPIS AACPTT+CAS+V CNG

WTIIIPISLAACPTTRCASIVSSCNG

52.9%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide

Lanthipeptides: KJS43_RS18000_lanthipeptide

IPISAAACPTTQCASVVKPCNG

IP+S A CPTT+CASVVKPCNG

IPVSLAICPTTKCASVVKPCNG

51.4%

NZ_JAMDLZ010000027.1:

Lanthipeptides: M5W82_RS15520_lanthipeptide

TITIPISAAACPTTQCASVVKPCNG

T+TIPIS A CPTT+CAS+V PC G

TVTIPISLAGCPTTKCASIVSPCKG

50.0%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide

Lanthipeptides: B2C77_RS21505_lanthipeptide

IPISAAACPTTQCASVVKPCN

IP+S A CPTT+CASVVKPCN

IPVSLAICPTTKCASVVKPCN

44.1%

NZ_CP040417.1and 7 others:

Lanthipeptides: FE328_RS09035_lanthipeptide

WTITIPISAAACPTTQCASVVKPCN

WT +PIS A CP+T+CAS+ +PCN

WTSLVPISLAICPSTKCASITRPCN

44.1%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

IPISAAACPTTQCASVVKPCNG

IP+S A CPTT+CAS+V+ CNG

IPVSLAICPTTRCASIVESCNG

44.1%

NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

DNQPATWTITIPISAAACPTTQCASVVKPC

D P T IP+S A CPTT C S PC

DTHPTTI---IPVSLAVCPTTTCRSFSSPC

MIBiG 4.0 matches for BK581_RS20095

24.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

ITIPISAAACPTTQCAS

+ + +SAA CPTT+C S

VAVGVSAAFCPTTKCTS

17.6%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

CPTTQCAS

CPTT+C S

CPTTKCTS

BK581_RS07320

Leader:

MEELYAIAGNVAEEMEEISLNSVSGG

Core:

ADVQGISQGNDGKYCTITWECSICPTHTCWC

Core with dehydrations:

ADVQGIDhaQGNDGKYCysDhbIDhbWECysDhaICysPDhbHDhbCysWCys

antiSMASH-DB 4.0 matches for BK581_RS07320

100.0%

NZ_KV917378.1and 1 other:

NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide

Lanthipeptides: BK581_RS07320_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTCWC

87.5%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide

Lanthipeptides: KJS43_RS18005_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTCWC

A+ GISQGNDGKYCTITWECSICPTHTCWC

AEPMGISQGNDGKYCTITWECSICPTHTCWC

83.9%

NZ_CP063142.1and 10 others:

Lanthipeptides: HPB58_RS21475_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTCWC

A+ +GISQGNDG CTITWECSICPTHTCWC

AEQRGISQGNDGHQCTITWECSICPTHTCWC

with 92 more sequence matches

Only the first 10 are displayed here.

81.2%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide

Lanthipeptides: B2C77_RS00795_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTCWC

A+ GISQGNDGK+CT+TWECSICPTHTCWC

AEPMGISQGNDGKWCTVTWECSICPTHTCWC

78.1%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide

Lanthipeptides: MFF31_RS04105_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTC-WC

A+ +GISQGNDGKYCT+TWECS+CPT TC WC

AEQRGISQGNDGKYCTLTWECSVCPTLTCFWC

78.1%

NZ_CP101913.1and 1 other:

NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide

Lanthipeptides: NP440_RS09135_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTCWC

A+ GIS+ NDGKYCT+TWECSICPTHTCWC

AEPMGISEDNDGKYCTLTWECSICPTHTCWC

77.4%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide

Lanthipeptides: WH45_RS23330_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTCWC

A+VQG+SQGNDGK CT+TWEC +CPTHTC+C

AEVQGLSQGNDGKVCTLTWECGLCPTHTCFC

75.8%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide

Lanthipeptides: BM124_RS15270_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTCWC

A+ +GISQGNDG YCTITWEC +CPTHTCWC

AEPRGISQGNDGDYCTITWECGMCPTHTCWC

69.7%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide

Lanthipeptides: G475_RS0114640_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTCWC

+ +G+SQGNDG YCTITWEC +CPTHTCWC

VETRGLSQGNDGDYCTITWECGMCPTHTCWC

65.6%

NZ_JAMDLZ010000027.1:

Lanthipeptides: M5W82_RS15515_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTCW

+ + IS+GNDGK+CT+TWECSICPT TCW

VETKKISKGNDGKWCTLTWECSICPTKTCW

63.2%

NC_023073.1and 73 others:

Lanthipeptides: U722_RS06170_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTCWC

A+ +GISQGNDGK CT+TWEC +CPTHTCWC

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

60.5%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide

Lanthipeptides: J7E20_RS10220_lanthipeptide

ADVQGISQGNDGKYCTITWECSICPTHTCWC

A+ +GISQGNDGK CT+TWEC +CPTHTC+C

AEQRGISQGNDGKLCTLTWECGLCPTHTCFC

50.0%

NZ_CP040417.1and 7 others:

Lanthipeptides: FE328_RS09040_lanthipeptide

VQGISQGNDGKYCTITWECSICPTHTCW

++ +S+GN GK CT+TWEC ICP+HTC+

IRKLSKGNTGKVCTLTWECGICPSHTCF

MIBiG 4.0 matches for BK581_RS07320

29.0%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

GNDGKYCTITWEC

GN G YCT+T EC

GNKGAYCTLTVEC

25.8%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

GNDGKYCTITWEC

GN+G +CT+T EC

GNNGGWCTLTKEC

10.3%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTITWEC

CT++ EC

CTLSKEC

allorf_1502358_1502453

Leader:

MGFYLKSRIKCLSTVGGLRTVIYF

Core:

TCSATLI

Core with dehydrations:

DhbCysDhaADhbLI

antiSMASH-DB 4.0 matches for allorf_1502358_1502453

100.0%

NZ_KV917378.1and 1 other:

NZ_KV917378.1 Lanthipeptides: allorf_1502358_1502453_lanthipeptide

Lanthipeptides: allorf_1502358_1502453_lanthipeptide

TCSATLI

allorf_1515636_1515734

Leader:

MSCFCGILLLFFVVHQIIEGEVGGA

Core:

RFYFRCS

Core with dehydrations:

RFYFRCysDha

antiSMASH-DB 4.0 matches for allorf_1515636_1515734

100.0%

NZ_KV917378.1and 1 other:

NZ_KV917378.1 Lanthipeptides: allorf_1515636_1515734_lanthipeptide

Lanthipeptides: allorf_1515636_1515734_lanthipeptide

RFYFRCS

allorf_1515683_1515811

Leader:

MNLPLRRVNDFLAYLVYTMVNITAA

Core:

RCRVSAVSCCYFLSFIK

Core with dehydrations:

RCysRVDhaAVDhaCysCysYFLDhaFIK

antiSMASH-DB 4.0 matches for allorf_1515683_1515811

100.0%

NZ_KV917378.1and 1 other:

NZ_KV917378.1 Lanthipeptides: allorf_1515683_1515811_lanthipeptide

Lanthipeptides: allorf_1515683_1515811_lanthipeptide

RCRVSAVSCCYFLSFIK

26.3%

NZ_CM000719.1:

Lanthipeptides: allorf_5300946_5301086_lanthipeptide

SCCYFLSFIK

C+FLSF+

GICFFLSFLP

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.99 out of 20.97

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26

Confidence: strong

Additional weak hits (3):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.92 out of 25.75

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 16.97 out of 20.47

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.46 out of 39.62

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

BK581_RS20095 - Class II

Cleavage pHMM score: 3.30

RODEO score: 0

Monoisotopic mass: 3314.6 Da

Molecular weight: 3316.7 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3334.7 Da N = 1; 3352.7 Da N = 2; 3370.8 Da N = 3; 3388.8 Da N = 4; 3406.8 Da N = 5

BK581_RS07320 - Class II

Cleavage pHMM score: -3.10

RODEO score: 0

Monoisotopic mass: 3310.4 Da

Molecular weight: 3312.7 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3330.7 Da N = 1

allorf_1502358_1502453 - Class II

Cleavage pHMM score: -7.10

RODEO score: 0

Monoisotopic mass: 653.4 Da

Molecular weight: 653.8 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 671.8 Da N = 1; 689.8 Da N = 2

allorf_1515636_1515734 - Class II

Cleavage pHMM score: -4.40

RODEO score: 0

Monoisotopic mass: 959.5 Da

Molecular weight: 960.1 Da

Number of bridges: 1

allorf_1515683_1515811 - Class II

Cleavage pHMM score: -4.70

RODEO score: 0

Monoisotopic mass: 1927.0 Da

Molecular weight: 1928.3 Da

Number of bridges: 3

BK581_RS20095 - Class II

Cleavage pHMM score: 3.30

RODEO score: 0

Monoisotopic mass: 3314.6 Da

Molecular weight: 3316.7 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3334.7 Da N = 1; 3352.7 Da N = 2; 3370.8 Da N = 3; 3388.8 Da N = 4; 3406.8 Da N = 5

BK581_RS07320 - Class II

Cleavage pHMM score: -3.10

RODEO score: 0

Monoisotopic mass: 3310.4 Da

Molecular weight: 3312.7 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3330.7 Da N = 1

allorf_1499673_1499759 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 1752.9 Da

Molecular weight: 1754.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1772.1 Da N = 1; 1790.1 Da N = 2

allorf_1502358_1502453 - Class II

Cleavage pHMM score: -7.10

RODEO score: 0

Monoisotopic mass: 653.4 Da

Molecular weight: 653.8 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 671.8 Da N = 1; 689.8 Da N = 2

allorf_1515636_1515734 - Class II

Cleavage pHMM score: -4.40

RODEO score: 0

Monoisotopic mass: 959.5 Da

Molecular weight: 960.1 Da

Number of bridges: 1

allorf_1515683_1515811 - Class II

Cleavage pHMM score: -4.70

RODEO score: 0

Monoisotopic mass: 1927.0 Da

Molecular weight: 1928.3 Da

Number of bridges: 3

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
CcpA	Catabolite control protein A

NZ_KV917378.1 - Region 4 - phosphonate

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Location: 1,960,718 - 1,979,722 nt. (total: 19,005 nt) Show pHMM detection rules used

phosphonate: (phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase or phosphonatesMeIsocitrateLyase))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

BK581_RS09275: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

Transferases: acetyltransferase

BK581_RS09250: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: peptidase

BK581_RS09310: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

Ligases: synthase

BK581_RS09300: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001859.4	0.57	other (phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000904.5	0.48	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0002670.2	0.43	other (other)	fosfonochlorin	Fusarium oxysporum f. sp. lycopersici 4287
BGC0000926.5	0.40	other (other)	rhizocticin A	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0002036.4	0.39	other (other)	dehydrofosmidomycin	Streptomyces lavendulae
BGC0000897.5	0.38	other (other)	dehydrophos	Streptomyces luridus
BGC0001739.3	0.38	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0000937.5	0.38	other (other)	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0000938.5	0.37	other (aminocoumarin)	fosfomycin	Streptomyces fradiae
BGC0000383.5	0.33	NRPS, PKS	luminmycin A, glidobactin A, cepafungin	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001859.4	0.57	other (phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000904.5	0.48	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0002670.2	0.43	other (other)	fosfonochlorin	Fusarium oxysporum f. sp. lycopersici 4287
BGC0000926.5	0.40	other (other)	rhizocticin A	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0002036.4	0.39	other (other)	dehydrofosmidomycin	Streptomyces lavendulae
BGC0000897.5	0.38	other (other)	dehydrophos	Streptomyces luridus
BGC0001739.3	0.38	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0000937.5	0.38	other (other)	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0000938.5	0.37	other (aminocoumarin)	fosfomycin	Streptomyces fradiae
BGC0000383.5	0.33	NRPS, PKS	luminmycin A, glidobactin A, cepafungin	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.34 out of 27.78

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.04 out of 27.78

Confidence: medium

Additional weak hits (2):

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.96 out of 25.88

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.53 out of 36.53

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_KV917378.1 - Region 5 - NRP-metallophore,NRPS

Download region GenBank file

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Location: 2,386,034 - 2,437,900 nt. (total: 51,867 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

BK581_RS11260: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

BK581_RS11325: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

BK581_RS11335: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: PPTase

BK581_RS11230: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: hydrolase

BK581_RS11245: isochorismatase

smcogs: SMCOG1027: isochorismatase

Isomerases: isomerase

BK581_RS11255: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthase

BK581_RS11240: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

BK581_RS11250: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

BK581_RS11310: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.5	1.00	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000401.5	0.97	NRPS	paenibactin	Paenibacillus elgii B69
BGC0000309.5	0.97	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0002695.2	0.96	NRPS	bacillibactin, bacillibactin E, bacillibactin F	Bacillus sp. WMMC1349
BGC0002075.3	0.85	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.77	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.74	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.74	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.74	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.72	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.5	0.79	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000401.5	0.78	NRPS	paenibactin	Paenibacillus elgii B69
BGC0000309.5	0.77	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0002695.2	0.77	NRPS	bacillibactin, bacillibactin E, bacillibactin F	Bacillus sp. WMMC1349
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.69	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.47 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.77 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.57 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.40 out of 29.38

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.52 out of 27.55

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.70 out of 29.38

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.37 out of 26.06

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.70 out of 29.25

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.89 out of 29.72

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

Additional weak hits (9):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.10 out of 32.74

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.96 out of 29.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.79 out of 30.25

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.94 out of 32.74

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.67 out of 32.74

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.92 out of 26.06

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.10 out of 32.74

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 25.07 out of 31.73

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.31 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 5, location 2386033 - 2437900:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

BK581_RS11240: Gly - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (460..858): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FAMTFDISALELQALVGGEINLYGPTETTIWSTL
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1518..1930): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LATHFDFSVWEGNQIFGGEINMYGITETTVHVSY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

BK581_RS11250: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (33..436): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SMSLYPLSSPGGAIQVGGSQQVYGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz PLPAQGVVNK (88% 8Å match); diOH-Bz or Sal PLPAQGVVNK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
FuR variant 1	Ferric Uptake Regulator
GnfM	Regulator of nitrogen-fixation genes
MogR	Repressor of flagellar motility genes
NtrC	Nitrogen regulatory protein C
SypG	Regulator of biofilm formation and host colonization
ZuR variant 1	Zinc-responsive repressor

NZ_KV917378.1 - Region 6 - opine-like-metallophore

Download region GenBank file

Download region SVG

Location: 2,528,639 - 2,550,764 nt. (total: 22,126 nt) Show pHMM detection rules used

opine-like-metallophore: (CntL and CntM)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: methyltransferase

BK581_RS11845: methyltransferase

smcogs: SMCOG1089: methyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002488.3	0.82	other (other)	bacillopaline	Paenibacillus mucilaginosus KNP414
BGC0002487.3	0.79	other (other)	staphylopine	Staphylococcus aureus subsp. aureus Mu50
BGC0002489.2	0.53	other (other)	pseudopaline	Pseudomonas aeruginosa PAO1
BGC0002490.2	0.50	other (other)	yersinopine	Yersinia pestis CO92
BGC0000513.3	0.41	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000551.5	0.41	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000504.5	0.40	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0000643.3	0.40	terpene	carotenoid	Brevundimonas vesicularis
BGC0000552.3	0.40	ribosomal	SmbA, SmbB	Streptococcus mutans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002488.3	0.82	other (other)	bacillopaline	Paenibacillus mucilaginosus KNP414
BGC0002487.3	0.79	other (other)	staphylopine	Staphylococcus aureus subsp. aureus Mu50
BGC0002489.2	0.53	other (other)	pseudopaline	Pseudomonas aeruginosa PAO1
BGC0002490.2	0.50	other (other)	yersinopine	Yersinia pestis CO92
BGC0000513.3	0.41	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000551.5	0.41	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000504.5	0.40	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0000643.3	0.40	terpene	carotenoid	Brevundimonas vesicularis
BGC0000552.3	0.40	ribosomal	SmbA, SmbB	Streptococcus mutans

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.70 out of 26.06

Confidence: medium

Additional weak hits (4):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.29 out of 25.75

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.15 out of 29.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.04 out of 29.38

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis

NZ_KV917378.1 - Region 7 - terpene

Download region GenBank file

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Location: 3,833,435 - 3,854,256 nt. (total: 20,822 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

BK581_RS17640: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000867.3	0.44	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000231.5	0.42	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001928.2	0.40	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000234.5	0.39	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000630.3	0.38	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000635.3	0.38	terpene	carotenoid	Paracoccus sp. N81106
BGC0000197.5	0.38	PKS, saccharide	aranciamycin	Streptomyces echinatus
BGC0000509.4	0.36	ribosomal	epilancin 15x	Staphylococcus epidermidis
BGC0000188.5	0.36	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0001723.5	0.36	PKS	oviedomycin	Streptomyces antibioticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000867.3	0.44	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000231.5	0.42	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001928.2	0.40	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000234.5	0.39	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000630.3	0.38	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000635.3	0.38	terpene	carotenoid	Paracoccus sp. N81106
BGC0000197.5	0.38	PKS, saccharide	aranciamycin	Streptomyces echinatus
BGC0000509.4	0.36	ribosomal	epilancin 15x	Staphylococcus epidermidis
BGC0000188.5	0.36	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0001723.5	0.36	PKS	oviedomycin	Streptomyces antibioticus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene		squalene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

BK581_RS17660: PT_phytoene_like

Domain 1 (15 - 258): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → PSPP; FPP → diapophytoene; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.54 out of 20.97

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 21.40 out of 23.05

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.30 out of 27.78

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.28 out of 19.52

Confidence: medium

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
AfsR	Pleiotropic regulatory for antibiotic production
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria