LOCUS       NZ_KV917378            28605 bp    DNA     linear   CON 10-DEC-2024
DEFINITION  Salipaludibacillus agaradhaerens strain DSM 8721 Scaffold1, whole
            genome shotgun sequence.
ACCESSION   NZ_KV917378
VERSION     NZ_KV917378.1
KEYWORDS    WGS; RefSeq.
SOURCE      Salipaludibacillus agaradhaerens
  ORGANISM  Salipaludibacillus agaradhaerens
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae.
REFERENCE   1  (bases 1 to 4319439)
  AUTHORS   Liu,B., Wang,J., Zhu,Y., Liu,G., Chen,Q., Chen,Z., Lan,J., Che,J.,
            Ge,C., Shi,H., Pan,Z. and Liu,X.
  TITLE     Genome sequencing project for genomic taxonomy and phylogenomics of
            Bacillus-like bacteria
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4319439)
  AUTHORS   Liu,B., Wang,J., Zhu,Y., Liu,G., Chen,Q., Chen,Z., Lan,J., Che,J.,
            Ge,C., Shi,H., Pan,Z. and Liu,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-JAN-2017) Agricultural Biological Resources Research
            Institute, Fujian Academy of Agricultural Sciences, No. 247, Wusi
            Road, Fuzhou, Fujian 350003, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 227.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002019735.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 15:23:16
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,010
            CDSs (total)                      :: 3,909
            Genes (coding)                    :: 3,871
            CDSs (with protein)               :: 3,871
            Genes (RNA)                       :: 101
            rRNAs                             :: 8, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 38
            CDSs (without protein)            :: 38
            Pseudo Genes (ambiguous residues) :: 0 of 38
            Pseudo Genes (frameshifted)       :: 17 of 38
            Pseudo Genes (incomplete)         :: 21 of 38
            Pseudo Genes (internal stop)      :: 7 of 38
            Pseudo Genes (multiple problems)  :: 5 of 38
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:59:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1496557
            Orig. end                         :: 1525162
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KV917378.1.
            Bacteria and source DNA available from DNA is available from: DSM
            or Fujian Academy of Agricultural Sciences.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..28605
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="3"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..28605
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..28605
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:18605](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..18605)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    complement(1086..1097)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.99"
                     /tool="antismash"
     gene            1502..2926
                     /locus_tag="BK581_RS07265"
     CDS             1502..2926
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1169: sugar
                     transport protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003463798.1"
                     /locus_tag="BK581_RS07265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar porter family MFS transporter"
                     /protein_id="WP_078577540.1"
                     /transl_table=11
                     /translation="MLEKHSSWYVILIAVSAGVAGLMYGFDTAVISGAIGFLAENYSLS
                     PAMQGWVISCVMIGGVLGVALSGFLSDKYGRKNIMFLSAILFIISALGSAFATGVTMLI
                     FARIIGGFGIGFASALSVTYISECAPPKIRGRLGSLYQLFTIFGICATFYINYGVANSG
                     SYAWGLDTGWRWMLGYGVFPGLIFFVLLFFIPESPRFLMQKGREKEAFQTLKRINGEAV
                     ARQEAKEIKISIETEKSSSIKQLLKPGLRMAMGVGIFLALFNQVIGMNAVTYYGPDIFR
                     SVGFENNTEFLATSIIGSVQVAFTIVALLLIDRLGRKKLMAIGSSLMAIFMVLIGSVFY
                     FEPINSGPLLVIFIAGFTAAFCVSMGPIPWIMIPEIFPNHLRAKAVGIATMFLWGANWA
                     IGQFTPILINNMGGAFTFWMFAVINVICFTFVMTIVPETKNKTLEEIGRFWKPKSEQGT
                     EFKKEFNKDLAAGKID"
     CDS             complement(3116..3202)
                     /gene="allorf_1499673_1499759"
                     /locus_tag="allorf_1499673_1499759"
                     /protein_id="allorf_1499673_1499759"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MKLERVERCVGGNSYTTCNIFLGMFLLA"
     CDS_motif       complement(3167..3202)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKLERVERCVGG"
                     /locus_tag="allorf_1499673_1499759_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(3116..3166)
                     /prepeptide="core"
                     /locus_tag="allorf_1499673_1499759_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.40"
                     /molecular_weight="1754.1"
                     /monoisotopic_mass="1752.9"
                     /core_sequence="NSYTTCNIFLGMFLLA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKLERVERCVGG"
                     /leader_location="[3166:3202](-)"
                     /alternative_weights="1772.1"
                     /alternative_weights="1790.1"
     misc_feature    complement(3307..3319)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 18.92"
                     /tool="antismash"
     gene            3668..3937
                     /gene="rpsN"
                     /locus_tag="BK581_RS07270"
     CDS             3668..3937
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpsN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009384394.1"
                     /locus_tag="BK581_RS07270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="30S ribosomal protein S14"
                     /protein_id="WP_078577541.1"
                     /transl_table=11
                     /translation="MAKKSMVAKERKRQALVAQYADLRRELKEKGDYEALRKLPRDSSP
                     TRLTRRCEMTGRPRAVLRKFKLSRIAFRELAHKGQLPGVKKSSW"
     gene            4002..5057
                     /locus_tag="BK581_RS07275"
     CDS             4002..5057
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1178: cobalamin synthesis protein/P47K family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019303.5"
                     /locus_tag="BK581_RS07275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GTP-binding protein"
                     /protein_id="WP_078577542.1"
                     /transl_table=11
                     /translation="MTDTFTLPITLVTGMTEQGKTSLIKQLNRYRVNTKKVIHFRDPNS
                     TYRCDAEGPYFQKTPVTEVFHDMEATSYDELMALLYHIQSQKDVDEIIVTKAYDSNLDL
                     LLYDTQKGGPFFQITHHIHVIDAVNFWFQYSSKDTVQTKSIFHAETVDHTIGELLVLQL
                     ELADSLYISNEHRLNEERLNELIWFLKKLNPLANIMTHANFNKHTSSIGDTIWPEEHKA
                     DYLYRHQLQAFKPKSPLALVGDYGIETFIYQSNSPASLSQLKAFFSHLPDGILRTKGVC
                     YTPFTHESHTISQVGASVEIMSEDPPYVKPSTSEYLTEFLFIGQHLNPQSIREKLDICL
                     SDVSYPLTKEH"
     gene            complement(5221..5667)
                     /locus_tag="BK581_RS07280"
     CDS             complement(5221..5667)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024093.5"
                     /locus_tag="BK581_RS07280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /protein_id="WP_169837597.1"
                     /transl_table=11
                     /translation="MCELDNVRLLVTKFADCYRFYKDILGFKVTWGDSRSGYVSFEAGK
                     NKEFAIFDRHAMAEAVGTTVLPTAVQAQDRFALIFKVEEELEQMVIRLQSQNVDIASGV
                     QDRPDWGIKAVHLRDPDGNLIELFSELSKDKWHRDLLEEDKKFN"
     CDS             5801..5896
                     /gene="allorf_1502358_1502453"
                     /locus_tag="allorf_1502358_1502453"
                     /protein_id="allorf_1502358_1502453"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MGFYLKSRIKCLSTVGGLRTVIYFTCSATLI"
     CDS_motif       5801..5872
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MGFYLKSRIKCLSTVGGLRTVIYF"
                     /locus_tag="allorf_1502358_1502453_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       5873..5896
                     /prepeptide="core"
                     /locus_tag="allorf_1502358_1502453_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.10"
                     /molecular_weight="653.8"
                     /monoisotopic_mass="653.4"
                     /core_sequence="TCSATLI"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGFYLKSRIKCLSTVGGLRTVIYF"
                     /leader_location="[5800:5872](+)"
                     /alternative_weights="671.8"
                     /alternative_weights="689.8"
     gene            6095..6856
                     /locus_tag="BK581_RS07285"
     CDS             6095..6856
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018707328.1"
                     /locus_tag="BK581_RS07285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_078577544.1"
                     /transl_table=11
                     /translation="MISIKEVSKQTGVTVRTLRHYDHIDLLKPSGKTDGGHRLYGEYEI
                     RKLQSIQFLKTLRFSLQDIKRLLGDENDDWYNQLQKQLNYCLQEKQKIEQVEKLLRGLM
                     NEFILKGENDLLHLQKLIRLYENNLSQKEQFLTEKFNKEERALLDLLPNMNQGDPDTVE
                     WLSLLAQLQKHMNKGIAADEVQGIIRRMLEKEKTTFGTNQAFSDKIWEIRKSPEASAKA
                     GFYPLDPEVLQFIEEAADYHDKHKTDAQNNY"
     gene            6878..7519
                     /locus_tag="BK581_RS07290"
     CDS             6878..7519
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017186247.1"
                     /locus_tag="BK581_RS07290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_078577545.1"
                     /transl_table=11
                     /translation="MTFFLDYQWEIFILVEILSLISLLLFGFFRYFLGRKHVSFIFIVI
                     FLVFLILEALLGLFIYTHTGEFSTFQIVITIFVIYACTFGIFDFLRLDRWMRRKIGKLR
                     NVELLTEKDYAILERNKNPKYLAKKYRISASVHLLVFLLGQSFLWFIGTSDLTEMVSYL
                     TDFSWVEAGTAANSPYANETMYAIGMLWGVIFIIDFIYSMSYTVFPSEKS"
     gene            7947..8396
                     /locus_tag="BK581_RS07295"
     CDS             7947..8396
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009329926.1"
                     /locus_tag="BK581_RS07295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GyrI-like domain-containing protein"
                     /protein_id="WP_078577546.1"
                     /transl_table=11
                     /translation="MTINIEIFPKYRIAYVRQVGPYGSANMQAMERLKKWAVKKNLLKS
                     AIILGIPQDNPETTPPESCRYDACIVISKNYQIDDSIEENELAEGKYVICKVKHTPEDV
                     QRAWTHIGTFLENTQYQIDNKPVVERYSFEMINNGYCELCVPIIS"
     gene            complement(8716..9834)
                     /locus_tag="BK581_RS07300"
     CDS             complement(8716..9834)
                     /EC_number="3.1.1.-"
                     /GO_function="GO:0052689 - carboxylic ester hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013877596.1"
                     /locus_tag="BK581_RS07300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="erythromycin esterase family protein"
                     /protein_id="WP_245828926.1"
                     /transl_table=11
                     /translation="MDIGQEESQYRFDFLKDQLKDKRFVFIGESSHCVKQYSMAKIQLI
                     KFLHAQLGFNVLAFESELGDCSIGDYLRKELTPLKFMEGSIGRVWHNDYNLELFNYMKD
                     TEEGTSLHLSGLDVQQSAGKHFIPFVESYLPSSVKQLLIEFERLTNYILEYGGFFKKRK
                     LKQSVSELDSLGTHLLKEVQGQKHQDKTLQHIIVRSIENRLAYCKANVQQSFFRQFELR
                     DQMMADNLQFLAEKIYPHEKFIIWAHNMHIRKNSKDSLLSPYKSILENLKDSIKNESFV
                     MALYAHNGEMSDQMGNAYSIKKSTRKHMEWLLNHAPYQNSFISSQLEWGEHKWRVYEGG
                     GLRQSLVPARQYDGLLFFKNVSPAFPKHEKVP"
     misc_feature    complement(9821..9835)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: weak, score: 16.97"
                     /tool="antismash"
     gene            complement(10001..12907)
                     /locus_tag="BK581_RS07305"
     CDS             complement(10001..12907)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="BK581_RS07305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_078577548.1"
                     /sec_met_domain="DUF4135 (E-value: 9.3e-85, bitscore:
                     282.9, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4.9e-50, bitscore:
                     168.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRYVEEASYQIVKESITEFNNVFNKDDFFIPFFSYFVSTFEKRV
                     TEAINRLPDDKVQKESLLASLLVNYKRKIVNVMSKMVIYEFHNTFEKYDPSDDTKYYKA
                     FNNLLGDPNNIEAILEKYPVLVEMITSIEDNFLHNHIKIIQRYQNDHTYIEKKLRITLG
                     DLLKASIDMGDTHRDGNSVAILECEENTLVYKPRSLTVDCLYEDIIIFFNETCQTNLKT
                     MRTCDRGDYGWQEYIEPLPLKEKQEAEVFYKELGMHLGFIYMFQGSDFHYENIMAHGSK
                     PVLIDLETLFQPNLYFNGVDEIEKPKQFLDNLNRTVYKSLFLNHTTYPEETKIMHLYAL
                     SNVENQSYDEEQVMYKGTDHLALQKVPTLMTRGDNLPVYQNEIIEIFGYEKEFIKGFEH
                     VYAFFRENYLSISKIINQFPDFPVRIVTRPTYIYTSFLKSLLHPKYLGEFSERERVLSF
                     FNDSYEDFQSFRTIVPYEKCDLYKGDVPYFYANFNETKLYNSQDEVVNCQIVKNSPKQE
                     VESRMANLSTEDLDFQVKLINMSLSASLANCDTHEVSNTEEVYRVGLEIKGIDDLLQKE
                     TTTIFNERLEYGDGVQWMSLSISPSGQMVAGPLSFGLYDGLAGIVLYLATYTHYHAPGA
                     IISDEKLQHIHHSVVNILENSTVKDSFSAYYGLGSYIYYIEKLRELNILTTENVTKQYE
                     KFCFQLTKNLDNIHATDFIGGLAGILKLLSLLYKNHKLPLLKKTASLVYRSLLSKVKGE
                     NNQLYWEADSFKDTVLTGFSHGLTGICYALSEFSLIASTETKKDIANVITKALRYEDKF
                     FDHDKRDWKDNRQNNMTFSSPFWCHGATGILLGRLKIKQNMGTMCSVNYINDALSTTLK
                     YGDDHTQGNSLCHGTLGNLDSLLAIKDDPFLAERKEEIEQTINKWLTHYREDMITNGWN
                     NGVKNDFSSVGFMLGRTGQLYTLLRAQNNHIPSVLLLD"
     misc_feature    complement(12961..12976)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     gene            complement(13002..13169)
                     /locus_tag="BK581_RS20095"
     CDS             complement(13002..13169)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016132309.1"
                     /locus_tag="BK581_RS20095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class II lanthipeptide, LchA2/BrtA2 family"
                     /protein_id="WP_169837599.1"
                     /transl_table=11
                     /translation="MKRVNGIEEISETELKNLAGGSNDNQPATWTITIPISAAACPTTQ
                     CASVVKPCNG"
     CDS_motif       complement(13107..13169)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKRVNGIEEISETELKNLAGG"
                     /locus_tag="BK581_RS20095_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13002..13106)
                     /prepeptide="core"
                     /locus_tag="BK581_RS20095_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="3.30"
                     /molecular_weight="3316.7"
                     /monoisotopic_mass="3314.6"
                     /core_sequence="SNDNQPATWTITIPISAAACPTTQCASVVKPCNG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKRVNGIEEISETELKNLAGG"
                     /leader_location="[13106:13169](-)"
                     /alternative_weights="3334.7"
                     /alternative_weights="3352.7"
                     /alternative_weights="3370.8"
                     /alternative_weights="3388.8"
                     /alternative_weights="3406.8"
     gene            complement(13301..15430)
                     /locus_tag="BK581_RS07310"
     CDS             complement(13301..15430)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003154889.1"
                     /locus_tag="BK581_RS07310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_078577549.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 4e-31, bitscore:
                     105.4, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLLKKKIPVILQKSNYDCGIICFAMIMSWEEGYRVDPRKLKQDR
                     KQIGREGTDLLYLKTLAKTHGYDLKAFKALNLTEKIAENALKCPMIVHWKNNHFVIIEK
                     IKDNTITIIDPAAGRKTILAEEFERDYSGVAIKLTKKDAARSHTKLKGVSLVNKIRKYL
                     LQEKKMLVYIILLSFVFQFLNLITPFLTQYVIDAFMDNKQTAIRLDLLAILGVCVTILF
                     FGLSILRMYWIIKLQVCINKGLTNQFIKKIFSLPMNFFEVNSSGDIATRINNIAVIREI
                     ISRLASTLILDISLLIVFCGVMLYYSPTLSLLVFIGAGLQVFFTTFLLPRIEMFTKQEV
                     NSQANFQSQLVEILRSMTFIKTVGDTKSIEMRMNQLFNDQIGHFSKRMNTSALLGGVSN
                     SINLSLPLFVLIIGIAIGMQNGLTIGTIVAFATIAGRFMAPLGSIIGSLESVKMVEEMV
                     DRVEYVLQEEDEQNNVESHATFNPATDDITFEHVHFSYDNGEDILSNISLVIHPKEKIT
                     LIGKTGSGKSTLFKLIAGLYPATKGSIYFGPHNIKDINLMKIRENIGFIVQDVSLFNET
                     IMNNIKYFNDLVSDDAAIQAAKDACIHDDIERLPMGYHTVIGENGVSLSGGQRQRIAIA
                     RVLAKDPKILLIDEGTSNLDKATEKEILFNLYKRDMTVVSITHRTDSISEYESIYELNN
                     GMLIQLKSRDKKQLV"
     gene            complement(15447..18605)
                     /locus_tag="BK581_RS07315"
     CDS             complement(15447..18605)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003154890.1"
                     /locus_tag="BK581_RS07315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_078577550.1"
                     /sec_met_domain="DUF4135 (E-value: 1.6e-95, bitscore:
                     318.3, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.8e-65, bitscore:
                     217.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNMLKILRCGEKKESGAAQDASLLDRNIDIVYKGDTQLATESLH
                     NVLSINSLERVRRLYNTDLHKYTFKLNVYQRLKQEIANQEIDPKERSEDILFHTFALKI
                     TSYFIKKLTVSNRYQAAKHNLKDESQFLKDVSTQFQKQILKTSYRTLVLDLNINRENGK
                     LQGNTKEEKYRYYNHILLNDSEYLNSFFDFYLGLLRIIANEIRKFKKFITELLTRYDHD
                     KLEISATLSNQTEIEQIETIEVGLGDAHSDGRKVAQVILENSVLIYKPRNLNIDLLYEK
                     IVVWLNEKVDGDQYQISTPKVISRKEYGWVEFIHYEECSDEQDIKNFYRRMGGQIALLY
                     TLNAVDFHSENIIANGSFPVLVDLESLFHIPYEHLKTDTESAYVKAEKKLNSSVRTLGL
                     LPFFFGKENVDISGIGRKGKVQSFIKLPQIKNPNKDDMKIEREYVSMDSSSNHPKWNGE
                     FVYAQDYVSEIKDGFAKVFETISSYSEEILKVINDFSDAVFVRFIPKPTVKYASFLELS
                     LHPRFLHNAIDREVYLAKIWEEIKVNENYIPLAKHEYSDLINDDIPYFKLPIHSKDLFT
                     SRNKVIADYFTHSPFELVRKKINGLSKEELDFQLEVIDLSMLASGDDRQRELKKFVTKN
                     PEDYKKPFHSQQYFIKKAEEIAEHIYSQSFKGTNNGKPNYSWLNSTPVGVEEIQWNLVP
                     MGDTMYDGLSGMAMTYLSLWIVTKKQKYLDIAIDIVEDISVRFKDLELSEERKTHISVG
                     AFSGVSSIIYMLMNFYIATKEKKYKELSLELTDKITILIEQDKEFDIIGGAAGAITVLI
                     SCYEWTRNDVFLKTAAQCCEHIMNNAVDINQNEISWVGVAEQPLTGYSHGNAGIIYSLS
                     LLNNYLKDETISEVIMKGMNYENNQMVQDNWIDRRKPIEEAATSAWCHGSPGILLSRLG
                     LAVSHEKKISQQAEIDMNMARDNIFYDGFGREHSLCHGDIGNAAILIAYGRETNQPDVV
                     EMAQNLMLESLQIGEEKGYKCGVGREVETPNLMVGMAGIIYGALFACDERVPNILSLKL
                     DKIE"
     gene            complement(18720..18893)
                     /locus_tag="BK581_RS07320"
     CDS             complement(18720..18893)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_ha"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003154891.1"
                     /locus_tag="BK581_RS07320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="plantaricin C family lantibiotic"
                     /protein_id="WP_078577551.1"
                     /sec_met_domain="mature_ha (E-value: 2.3e-05, bitscore:
                     21.9, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEELYAIAGNVAEEMEEISLNSVSGGADVQGISQGNDGKYCTITW
                     ECSICPTHTCWC"
     CDS_motif       complement(18816..18893)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEELYAIAGNVAEEMEEISLNSVSGG"
                     /locus_tag="BK581_RS07320_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(18720..18815)
                     /prepeptide="core"
                     /locus_tag="BK581_RS07320_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.10"
                     /molecular_weight="3312.7"
                     /monoisotopic_mass="3310.4"
                     /core_sequence="ADVQGISQGNDGKYCTITWECSICPTHTCWC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEELYAIAGNVAEEMEEISLNSVSGG"
                     /leader_location="[18815:18893](-)"
                     /alternative_weights="3330.7"
     misc_feature    18978..18998
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 25.46"
                     /tool="antismash"
     CDS             complement(19079..19177)
                     /gene="allorf_1515636_1515734"
                     /locus_tag="allorf_1515636_1515734"
                     /protein_id="allorf_1515636_1515734"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MSCFCGILLLFFVVHQIIEGEVGGARFYFRCS"
     CDS_motif       complement(19103..19177)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSCFCGILLLFFVVHQIIEGEVGGA"
                     /locus_tag="allorf_1515636_1515734_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(19079..19102)
                     /prepeptide="core"
                     /locus_tag="allorf_1515636_1515734_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.40"
                     /molecular_weight="960.1"
                     /monoisotopic_mass="959.5"
                     /core_sequence="RFYFRCS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSCFCGILLLFFVVHQIIEGEVGGA"
                     /leader_location="[19102:19177](-)"
     CDS             complement(19126..19254)
                     /gene="allorf_1515683_1515811"
                     /locus_tag="allorf_1515683_1515811"
                     /protein_id="allorf_1515683_1515811"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MNLPLRRVNDFLAYLVYTMVNITAARCRVSAVSCCYFLSFIK"
     CDS_motif       complement(19180..19254)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNLPLRRVNDFLAYLVYTMVNITAA"
                     /locus_tag="allorf_1515683_1515811_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(19126..19179)
                     /prepeptide="core"
                     /locus_tag="allorf_1515683_1515811_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.70"
                     /molecular_weight="1928.3"
                     /monoisotopic_mass="1927.0"
                     /core_sequence="RCRVSAVSCCYFLSFIK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNLPLRRVNDFLAYLVYTMVNITAA"
                     /leader_location="[19179:19254](-)"
     gene            complement(19316..19975)
                     /locus_tag="BK581_RS07325"
     CDS             complement(19316..19975)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003154892.1"
                     /locus_tag="BK581_RS07325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_078577552.1"
                     /transl_table=11
                     /translation="MINMLLVDDHVCVVQGLKLLLEKNKTMAVDIATDSRNVLERIGNV
                     DYDVILLDLFMSYLNGFELSKQILMNDPDKRILIFTGGDISQYFNVLMEIGVSGFISKE
                     ASYETVINTIECVVRGETVLPTQLFKQLRRTEPKAELTTKHGLRDITLKEREQKIILSI
                     SEGLTNREIADRLLISQRAVEYSLTEIYHKLGVKSRTEALSKANKYSLITLKEIPS"
     gene            complement(20214..20408)
                     /locus_tag="BK581_RS07330"
     CDS             complement(20214..20408)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BK581_RS07330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_078577553.1"
                     /transl_table=11
                     /translation="MEKITFIIAIISLGGALAVFIANLLNFGLKGGILNKGRKSTKWVI
                     GLFIVYIISFAMFIFISSN"
     gene            complement(20492..21226)
                     /locus_tag="BK581_RS07335"
     CDS             complement(20492..21226)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017417590.1"
                     /locus_tag="BK581_RS07335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_078577554.1"
                     /transl_table=11
                     /translation="MNLLIKNELTKLKRLKMVYVILVVSFLPFLINTAGMLMMSGEMDA
                     GKYYYFVFNQYAILFPTLVFIFTGFFFYTEFQNRTTLNWISYPFHNFSLMGSKMIAAFI
                     LLLGTAILNHVIHLVTLWVLFRTEIQLMTVVTHFFTSFLFSFLILLIIPVAALLVFMTR
                     NILSVVIAGVAFIFVTTILLGADFSIIFPFSFAYRLSIQFFDSSMGYGRTQLELWGSAI
                     FFAYIATSLLGLYKYSQKTRMS"
     gene            complement(21210..22136)
                     /locus_tag="BK581_RS07340"
     CDS             complement(21210..22136)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019393717.1"
                     /locus_tag="BK581_RS07340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_078577555.1"
                     /transl_table=11
                     /translation="MENILKVEDLTVKIKKKTVLSEVNLNIEKGKIYGLLGPNGAGKTT
                     LLKVLLGVFRPTSGTITFQGQNLYDHPDKSLISSIGSIIEFPGFYDNLTLMENLLLHMR
                     YLNQDLSEAHICSLLKKVGLYKHKEKLFSETSLGMKQRLGIARAMAHQPKLLLLDEPTN
                     GLDPHGIKEVREMLIQEVASKGTTVIISSHLLNEIDLMADDIIFMNNGNIIFEMAMNMV
                     DRTKNYMYKLSTPFDLQPELMTELHGQRIFQEEDYVEFVSPFGQREVKVLLEQYKIPVI
                     KLEVFELSLEDLYLKLLSRGEEYELTY"
     gene            complement(22344..23702)
                     /locus_tag="BK581_RS07345"
     CDS             complement(22344..23702)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.5"
                     /locus_tag="BK581_RS07345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_078577556.1"
                     /transl_table=11
                     /translation="MKLSTKYIMIILLSLFIFPISYLGVNFLYYSVIMQLGNFTSEEFY
                     EQDEIEEEWNKQVTSLTGMANDDVIDHLKSIDLFPESMIFWLSDEGDLLMSDGQTEDLN
                     EKWRVSETIAYMKAEQEDDYFTTFSYVEGAENSGYALLRIPQAYIGSEWEVLRDRYSFV
                     WFIALGLIWFLFVFISWVFFNQLRKRLVRIQKNMEVSKNQLVPSEMNVEKDDEIGQLEH
                     SFNRMVKQLKESREKEKTEEVIRKRLIANLSHDLRTPLSIINGHSHKLNQYELNPRANE
                     SLKIINEKVNFMAELIDNLSSYTVLSEGKLPINKQSLNITTVVRSSIIAWYPIFEELGF
                     DIEVDLTLPIEWEVDETWLRRVLDNLFQNVQRHAREGKYIAVKTMREQGTSVLKICDHG
                     PGMTTPSKLSGAGIGLSIVDMMLQQMNLKKTVSDKTLGTTITIQPIVKKTGSE"
     gene            complement(23699..24373)
                     /locus_tag="BK581_RS07350"
     CDS             complement(23699..24373)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019393719.1"
                     /locus_tag="BK581_RS07350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_078577557.1"
                     /transl_table=11
                     /translation="MGNHILYIEDDNEVGDLVKQNLIDNGYELTWLKSGNQFDRYLDKV
                     EMVILDIMLPGLDGFTVGQRIKEMNETIPILFLTARTAIEDKLKGLEFADDYLTKPFHP
                     KELLLRIDILLRRFEKVTLDVVYIDHLKVDLKANQIFNTETNEEIFLTEKQFKIFHYLL
                     RNTNQILTKEQIYSNVWNQPYIEGDKTLNVHIRYLRQKIEKKPEDPKIIQTIRGLGYRV
                     KQ"
     gene            complement(25121..26032)
                     /locus_tag="BK581_RS07355"
     CDS             complement(25121..26032)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017472035.1"
                     /locus_tag="BK581_RS07355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_078577558.1"
                     /transl_table=11
                     /translation="MHSWEQIQKTVDYIEEHLSEEIKIEGLAKKAALSQFYFQRLFKRL
                     VKRSVNEYIKLRRLARASEKLGDLSKRIIDIALDFGFSSHETFTRAFKEAYGITPEEYR
                     THPVHLNHIMKPELLLKYTVVDLGVPLITDSMVLEIKRKTLEVAETYIGLSGQVLISQT
                     PIGETTGVDEPGQLWDTFHSMVSHLPILKPDGKEVGVSSMGDDGQNTFTYFVGGEMSAT
                     SYDAGEFVTWSLPPGEYVVCCFEAENFQLLTTSVLSKAMNYLFGTWLVNHQLATHPFSV
                     EKYYKTNSDVAYMEIWVRPVGK"
     gene            26414..26866
                     /locus_tag="BK581_RS07360"
     CDS             26414..26866
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003321836.1"
                     /locus_tag="BK581_RS07360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="OsmC family protein"
                     /protein_id="WP_078577559.1"
                     /transl_table=11
                     /translation="MAEHRFHLKANWPGLRNDVGEIETANLFTKVSIPPEMDGPGIGTN
                     PDEMLLGAAATCYIITLAAMMERSQLDKVSLTMTSVGIVDVTNGTITYKKIIHRPDIVL
                     KSSVNDGDFKLADKLANNAEKVCMISRALQGNVTIDVYPTISAASE"
     gene            complement(27147..27590)
                     /locus_tag="BK581_RS07365"
     CDS             complement(27147..27590)
                     /EC_number="2.1.1.100"
                     /EC_number="2.1.1.334"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016107.5"
                     /locus_tag="BK581_RS07365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="isoprenylcysteine carboxylmethyltransferase
                     family protein"
                     /protein_id="WP_078577560.1"
                     /transl_table=11
                     /translation="MSYLLPPVLFILCIVSMIIGHILFPINFFIQVPYNLFGVLLILIG
                     GRATLQGARLFKIKGTTEMTFNEPDLLVTEGLYKRTRNPMYLGFLIMLLGLAVVLGSLS
                     PFIVVVGFFIITNFWYIKFEEKMLEEKFGETYRAYKKSVRRWL"
ORIGIN
        1 atgatgagaa gagacagcag tttgtaagga gaattattcc ttcagtacaa agcaagctga
       61 tagggtgtca cgtatttgca ggtgttggaa cggttgtttc tgacattact caaattgggg
      121 actcttataa ggaagccatt tatgcgttgg aacttgtaca caatcatcca actgcctctt
      181 atatggtgta caatgacaaa ttaaaacaga aacgcgccga gctacttcca tttgaaattg
      241 aaaaagattt agtggaagct atcaaaacag gtgattctca aaaaggattg catctgtttg
      301 aaacctattt caacgtgatt caacaagcct cagattatca agtaagaaca atacataaag
      361 caatggagaa tttctatatt gttctcactc gctctctaca agagcttggt tttgaagagg
      421 acattcaaat tagtgtagga caattagaaa catcgatgca aataaaggaa gctgcaaaag
      481 tacaattaat tgatctgatc acacgtctac gagaatggcg tgcccatggt attcacttcc
      541 tactcctaca agcaaaagac tatattgatc aacattacga ccaggtcatc acgcttgaag
      601 aggtggccaa tcacattggc attagttcat attatttaag cagattattt aaagataagt
      661 ttcatgtaac atttattgag tatctcactt ctgtcagact acaaagagct aaaggtttct
      721 tactagatgg ctcaatgtca ttaaaggaaa tcgcactgaa cattggctat aaagacccta
      781 attatttcag tagagtcttc aaaaaagaga ctggtctaag tcccactggc tatagaagta
      841 agtatcaaca gtagtgttat ttttgcgagt ttatataaaa acgggcattg agctatgagg
      901 atagcttgat gcccgttttt gcatatagtc cacatacttg tttattgcaa acttttatag
      961 atgcaaataa cataccaatg agcgtcttga ggtagttaat tcatattact tctgaaaata
     1021 caatattttc gcaaagaaag ttggctttaa caaaataatc tagatgataa caacaaattg
     1081 aagaagaaag cgctttccga taaaaaaccg tgtgttaaat taagtttgtt gaaagcgtaa
     1141 tcattaaaag ttcgagatta agaaatagac ataaaaagag aatgaagcaa tttaattagg
     1201 acggttcaca caacgaataa ttttgattgc ttctcttaaa atgtttgttt aattaaggtg
     1261 atcactgctt aagatgattc cctgaggata aaacgctttc tgaagattca cttttgcaag
     1321 atgtatattt ataaaacctt caatgagtgg acgtttcact tctcctactg attgatagtt
     1381 gaatgaagga gattcacgtc catctacaag agatcactgg catcattcgt gttttaccga
     1441 gaatatttat attgtgaaat taattgaaga acaaaaaaat gctttatgag gaggactaac
     1501 catgttagag aaacattcat cttggtatgt tattttaatt gcagtttcag caggggtcgc
     1561 tggactaatg tatggttttg atacagcagt tatttcaggc gctatcggtt ttcttgctga
     1621 aaattatagc ttatcgccgg cgatgcaagg gtgggttatt tcttgtgtta tgatcggtgg
     1681 tgtgcttggg gtagcgctgt ctggcttctt aagtgacaaa tatggtagaa aaaatattat
     1741 gtttctatct gcaatccttt ttatcatttc tgcattaggc tctgcttttg caactggtgt
     1801 gacgatgtta atcttcgcaa gaattattgg gggattcgga attggatttg cttccgcttt
     1861 atctgtaaca tatatcagtg agtgtgcacc gccaaaaatt cgtggcagac tcggctctct
     1921 ttatcaatta ttcactatct tcggtatttg tgcgacgttc tacattaact atggggttgc
     1981 taacagcggt agttatgctt gggggttaga tacagggtgg cgctggatgc taggttacgg
     2041 tgtttttcca ggtttaatat tttttgttct actattcttc attcctgaaa gcccaaggtt
     2101 tttaatgcaa aaaggtagag aaaaggaagc atttcaaacc ttaaagcgaa taaacggaga
     2161 agcagtagcc agacaagaag ctaaggaaat taaaatctca attgaaacgg aaaagagctc
     2221 atctattaaa caattactaa agcctggtct gcgtatggca atgggggttg gtattttctt
     2281 agcattgttt aatcaagtaa ttgggatgaa tgccgtcaca tactatgggc cagatatttt
     2341 ccggagcgtt ggatttgaaa ataacacaga attccttgcc acaagtatta ttggtagtgt
     2401 gcaagtagca tttaccatag tggcgctcct gctaattgat agattaggaa gaaagaaatt
     2461 aatggccatt ggttcaagcc ttatggcaat tttcatggta ctcattggaa gtgtattcta
     2521 ctttgagcct atcaatagtg gtcccctact agtcattttt atagctggtt ttacagcagc
     2581 attctgtgtc tccatggggc ccattccatg gattatgatt ccagaaatct tccccaatca
     2641 ccttcgtgcg aaagctgtcg gtatcgcaac tatgttccta tggggagcta actgggcaat
     2701 cggtcagttc acaccgattt taatcaataa catgggtggc gcttttacat tttggatgtt
     2761 cgctgttatt aacgtcattt gctttacctt tgtaatgacc atagtacctg aaacaaaaaa
     2821 taaaacgtta gaagagatcg gacgcttttg gaaacctaaa agtgagcaag gcacagagtt
     2881 taaaaaagaa tttaacaaag atttagctgc aggaaaaata gattaggaga acctcaatag
     2941 cttaaacttt cagggaacaa gtggcttttc gttcagccat atgattgcga agatcttttt
     3001 gccacttgtt tctttatcta agcatacctc acttcaaacc atgattttac ttcactaaca
     3061 accacgtaaa tatgaaaccg aatagctaaa gtatgttatt ttgaaggaca tttagctatg
     3121 ctaaaagaaa cattcccaag aagatgttac atgtcgtgta gctgttgcct cccacacatc
     3181 tttcaactct ctctaacttc actttctcct ttactcttct cttttgctat ctgtttaagc
     3241 atcctattaa tattattcaa acttagtaaa ataaagccta acataacaaa tgtcacaatt
     3301 tctccagtga aaatgacact tcagctcata ttaaaaaata aacactatat accatcaatt
     3361 gttcatcgtt ttcatccttc ttagttttat aacacgagcc tttaatcagt gaacgttttc
     3421 cctgattgtt agttgagtca atcaggacat taccggacgt tagcccccct aaatagatgt
     3481 cactctcctc tctattttca accggaagtt ttacggacgg ttatagtaat tgccactttt
     3541 tagcacctaa tcaagtcata gcacgtaaaa ctgtaatttg cctgctcttt acttcattga
     3601 atttttacgg tatgataatg ccataaatcg taattgtttc gatttaatta atgaaaggat
     3661 gatatatgtg gctaaaaaat cgatggtagc aaaggaaaga aaacgacaag cccttgtggc
     3721 acaatacgca gatttacgaa gagagttaaa ggaaaaaggc gactacgaag cgttaagaaa
     3781 attacctaga gactcctccc ctactcgcct gacgagaagg tgtgaaatga ccggaagacc
     3841 tcgcgctgta ttacgtaagt ttaaactttc aagaattgcg tttagagaac tagcacataa
     3901 agggcaactc ccaggtgtga aaaaatcaag ttggtaactc cccatcactt ttcgcctaac
     3961 tggtgcctga acaaccttta ttctctttaa ggagagatac aatgactgac acttttacat
     4021 taccgataac actcgtaact gggatgactg agcagggaaa aacctcactt attaagcagc
     4081 tcaatcgata cagggttaat acaaaaaaag tgatccattt ccgtgaccca aatagcacct
     4141 ataggtgtga tgctgaaggt ccgtactttc agaaaacacc ggtgacagaa gtctttcatg
     4201 atatggaagc aacctcttat gacgagctaa tggcgttgct atatcatatt caaagtcaga
     4261 aagatgtgga cgaaatcatc gtgactaaag cgtatgattc taatttagat ttacttctct
     4321 acgacactca aaaaggggga cctttctttc aaatcacaca ccacatccat gtaatagatg
     4381 ctgtaaactt ttggtttcaa tattcatcaa aggatacggt tcaaactaag tcgatatttc
     4441 atgcagaaac ggtcgatcat acaattggag aattgcttgt tcttcaatta gaattggctg
     4501 atagtctata tatatccaat gaacaccggc tgaatgaaga acgcttaaat gaactaatct
     4561 ggtttctaaa aaagctcaac cctttggcaa atattatgac gcatgctaat tttaacaagc
     4621 atacgtcttc cataggtgat acaatctggc ctgaggaaca caaggccgac tacctttacc
     4681 gccatcaact gcaagcattc aaaccgaaaa gtcctttagc actagtggga gattacggaa
     4741 tagagacatt tatttaccaa agcaactctc ctgcttcctt aagtcagctt aaagcttttt
     4801 tttcacatct gcctgacggt attctgcgaa caaaaggggt gtgttatact ccttttacac
     4861 atgagagtca cactatttcc caagtaggtg cttcagttga aattatgtca gaagatcccc
     4921 cctatgtgaa accttcaacc tctgaatatt taactgaatt tttgttcata ggtcagcatc
     4981 taaatccaca aagcattcga gaaaaactag atatatgtct atcagatgtg agctatcctt
     5041 taacaaagga gcattgaatt atctcgttac aatcctctgc aatcagtgag agctttcgtt
     5101 cttctcccac tgattggccg ttgagtacat catgacatga gcaaccgtta tctcccgcct
     5161 aaatagagtt tgctttcttc tctattggag gcgggattta cggacgatca tctgtgataa
     5221 ttagttaaat ttcttatctt cttcaagtag atcacggtgc catttatcct ttgataattc
     5281 ggaaaacaat tcaatcaaat tgccatctgg atctctaaga tgaactgctt taatacccca
     5341 atcaggtcta tcttgaaccc cgctagcgat gtctacgttt tgtgactgta ggcgaataac
     5401 catttgttct aactcttctt ccactttaaa aattaatgca aaacgatctt gtgcctgaac
     5461 agctgttggt aaaacggttg tccctaccgc ctcagccatc gcatgacgat caaaaatagc
     5521 gaattcttta ttcttaccag cttcaaaact tacataacca cttctgctgt caccccatgt
     5581 taccttaaac ccgagaatat ctttatagaa tcggtaacaa tctgcaaatt tagtcactaa
     5641 caaacggaca ttatctagct cacacattgt tatactctct cccttcatat gaaattacca
     5701 ttcattttat agaaataaat ccattatgac ttgtaaaaat cggacattcg gtatttttaa
     5761 tactgttaaa aagtgaagaa ataaagctaa gcttcaatcg gtggggtttt accttaaaag
     5821 taggataaaa tgcctttcaa cagtgggagg tttacggacg gttatctatt tcacatgctc
     5881 cgccacgtta atttaaacga aattaactat tgaaagtgac gtaacgtcat tttgtataat
     5941 aaaataaggt ggacaattca tttcagtgag ctgaaacatc gagaaatcag gtgacgtgct
     6001 gctcatctga ttaagttccc cacctagtac gctgctggct acccctttaa agcatttgag
     6061 aactaattaa cattaggagg acaaaccatt ttctatgatt tctattaaag aggtgtctaa
     6121 acagacaggt gttacagtga gaacactacg tcattatgac catattgatt tgttaaagcc
     6181 ttcagggaaa acggacggcg ggcatcgact atatggtgaa tatgaaatta gaaaattaca
     6241 gagcattcaa tttttaaaaa cattgcggtt tagtttacag gacattaaac gtcttttagg
     6301 tgacgaaaat gatgattggt acaatcaatt acaaaagcaa ttgaactact gtttacagga
     6361 gaaacaaaaa atcgaacaag tagagaaatt acttcgtggc ctcatgaatg aatttatatt
     6421 aaagggggaa aatgacctcc ttcatttaca aaaacttatt cgattatatg aaaacaacct
     6481 atctcagaaa gaacagtttt taacggaaaa atttaacaaa gaagaaagag ccttattaga
     6541 ccttttacca aatatgaatc aaggtgatcc agatacagtg gagtggctgt ccttattagc
     6601 tcaattacaa aaacatatga ataaaggcat tgcagcagat gaagtccaag gtattattag
     6661 gcggatgctt gaaaaagaaa aaaccacttt tggaacgaat caagcattct ccgataaaat
     6721 ttgggagata agaaaatcac cagaagcctc ggccaaggca ggcttttacc cgcttgatcc
     6781 tgaagttctt caatttattg aggaagcagc agattatcat gacaaacata aaacagatgc
     6841 tcaaaacaat tattagcctc acgaagggag ctgtccgatg acattctttt tagattatca
     6901 atgggagatc tttattttgg tagaaattct ctctcttatt tcgttacttc tttttggatt
     6961 tttccgctat tttttaggaa gaaagcacgt tagctttata ttcatagtta tttttcttgt
     7021 gtttcttatc ctagaagctt tactcggcct tttcatctac acacatactg gagaattttc
     7081 cacctttcaa atagtcatta ccatttttgt gatctatgca tgtacctttg gtatctttga
     7141 ctttcttcga ctcgaccggt ggatgcgccg taaaattgga aaacttcgaa acgtggaatt
     7201 acttacagaa aaagattacg ctattcttga gcgtaataaa aatccgaaat atttagctaa
     7261 aaaatatcga attagtgcgt cagtacactt actcgtcttt ctcttagggc aaagtttttt
     7321 gtggttcata ggtactagcg atctgactga aatggtcagc tacctcacag atttttcctg
     7381 ggtagaagcc ggaacagctg ccaattctcc atatgctaac gaaacgatgt atgcaattgg
     7441 catgctgtgg ggagtcattt ttatcatcga ttttatctat tctatgtctt atacggtttt
     7501 cccaagcgag aagtcataag tacttgacgc ctagtcatta tcattaaata atgttatggg
     7561 gacgactaaa gcgactgatc tattcattca gtcgtttttc tatttcgaaa ctaatttttg
     7621 tctgaccgtt atcatgtgag acatccactc gacctaattt cataatacat atacctactc
     7681 atacattgat cttccgctac aggtggacgg ttactgtgat aaaacctctc acatcaatgc
     7741 atcttcaaac tccgttcatc ttcttagagt caccgtcttt caacaaaccc ctttaaaaaa
     7801 agcccaaatg atagaaactt tttgtcttta gtcacttgtt cgtgttaacc attcattctt
     7861 aaattttaaa aaatgatatg actatatttt tataccatgt tacattcgat gtacgtcacc
     7921 tattactaaa caaaggagaa ggaataatga ctattaacat tgaaatattt ccaaagtacc
     7981 gcattgcata tgtaaggcaa gttggtccat atggctctgc taacatgcaa gcaatggaaa
     8041 gattaaaaaa gtgggctgtg aagaaaaatc ttctaaaatc agctataata cttggcattc
     8101 ctcaagataa ccctgagacc acacctcctg agagctgtag gtatgatgca tgtattgtga
     8161 tttcaaaaaa ctatcaaatt gatgactcga tcgaagaaaa tgaacttgct gaggggaaat
     8221 atgttatatg caaagtcaaa cacacaccgg aagatgttca aagagcctgg actcatatag
     8281 gtacttttct agaaaacact cagtaccaaa ttgataacaa accagttgta gaaaggtatt
     8341 catttgagat gattaacaac ggttattgtg aattatgtgt ccctatcata tcgtaatgtt
     8401 gactcgtttt aactcttata gacaagacgt tatccatatc ccgctaacgt cttgtccttt
     8461 ggataagtaa atcttgttct catttttcaa agtctaatat gttcctcagc ttaaacgata
     8521 tgacatacct gccagcgttt tttgcaatag agttatttcg gccatgctct taacgtatct
     8581 cgctccttca catcggtcgt tgtttcttcg agtgtctact agactaatgt gtaacatcaa
     8641 tagaaatgat aagacgtgag gctgtgccgt ttattctggc gcgtttgagc taaaaagatg
     8701 tgagagtgct gcacattacg gcactttttc gtgtttagga aaagcaggtg agacattttt
     8761 gaaaaatagt agtccatcgt actgacgagc tgggactagt gattgacgta ggcccccacc
     8821 ctcatatact ctccatttat gctctcccca ttcaagttga cttgatatga agctattctg
     8881 ataaggtgca tggttgagta accattccat atgcttgcgt gtcgattttt ttatggaata
     8941 agcatttccc atctgatcac tcatctcgcc attatgtgca tagagagcca ttacaaagct
     9001 ttcatttttt attgagtctt tgagattttc aaggatggac ttataagggg aaagcagact
     9061 atctttgcta ttttttcgaa tgtgcatatt atgggcccaa ataatgaatt tctcatgggg
     9121 atagattttc tcagccagga actgtaagtt atcagccatc atttgatctc tcaattcaaa
     9181 ttgtctgaag aagctttgtt gaacattagc tttgcagtac gctaacctat tctctataga
     9241 acgaacgatt atgtgttgca atgttttatc ctgatgtttt tgtccctgta cttcttttag
     9301 caaatgtgtg ccaaggctat cgagctcgct gacagactgc tttaactttc tttttttaaa
     9361 gaatcctcca tactctaaaa tatagttggt taaacgttca aattctatca ataactgctt
     9421 cacagacgag gggagatacg attcaacaaa cggaataaaa tgcttgcctg cgctttgctg
     9481 aacatccaga cctgataaat gtaaagacgt tccctcctcc gtgtctttca tgtaattaaa
     9541 taattcaaga ttatagtcat tgtgccaaac tctccctata gacccttcca taaactttag
     9601 tggcgttagc tccttgcgta aataatcacc gattgaacaa tctcctaatt cactctcaaa
     9661 cgctagaaca ttgaaaccta attgcgcatg caggaattta atgagttgta ttttcgccat
     9721 gctgtattgt ttgacacaat ggctgctctc tcctataaac acaaaccttt tatcttttag
     9781 ttgatctttc aaaaagtcaa aacggtattg cgactcctct tggccgatat ccacactttt
     9841 ttcttgtact tcttttatta ggctctccgt gttcatcctc gcattcctcc catcacgatt
     9901 aggctgtgac accctctgaa tttaaactgt aaaggtgagg atagtaacgt ttcattttaa
     9961 acgctgtctc ataaactgga aacaatgagg gaggaggaag tcaatctagt aacaaaacag
    10021 aaggaatgtg attattttgt gctcttaata gtgtgtataa ttgacccgtt ctaccaagca
    10081 taaaaccaac acttgaaaaa tcatttttca caccattgtt ccaaccattt gtaatcatat
    10141 cctcacgata atgagttaac catttgttaa tcgtttgttc aatttcttct ttcctctctg
    10201 ctaagaaggg atcgtctttt atcgcaagta aactatcaag gttgcctaac gtgccatgac
    10261 ataaggaatt tccttgtgta tgatcgtcac cgtattttaa agtggtggat aacgcgtcat
    10321 taatataatt taccgagcac atcgtcccca tattttgctt aattttcaac cttcctagta
    10381 aaatccctgt agcaccatga caccaaaaag gggaagaaaa agtcatgtta ttttgtcggt
    10441 tatctttcca atcacgttta tcatgatcga agaatttatc ttcataacgt aaagcttttg
    10501 taataacatt tgctatgtct ttttttgttt cagttgatgc gatcagcgag aattctgaca
    10561 gagcataaca tatacctgtt aagccatgag aaaaacctgt taatacagta tctttaaaag
    10621 aatctgcttc ccaatataac tgattattct ctcccttaac tttggaaaga agcgaacgat
    10681 aaacgagaga cgcagtcttc tttagcaaag gtaacttatg atttttgtaa agcaggctaa
    10741 gtagtttgag gatacctgct aatccaccga taaaatcagt tgcatggata ttatcaaggt
    10801 tcttagttag ctggaaacaa aacttttcat actgtttggt gacattttcc gtcgttaata
    10861 tatttaattc tctaagcttt tcgatataat agatatacga tcctaagcca taataagctg
    10921 aaaagctatc tttcaccgtg ctattttcta gtatgttgac tactgaatga tgtatatgtt
    10981 gtagtttttc atccgaaatt attgctcctg gtgcatgata atgagtatac gtagctaagt
    11041 ataatacaat accagcgagt ccatcatata atccgaaact tagaggccca gccaccatct
    11101 gtccggatgg acttatagat aacgacatcc actgaacgcc atctccatat tctaagcgtt
    11161 cgttaaaaat agttgtcgtc tctttttgta gtaaatcatc tatacctttt atttccaatc
    11221 ccaccctata cacttcctcc gtattagaaa cctcatgtgt atcacaatta gccaaactag
    11281 ctgacaatga catattaatt aatttcactt gaaaatcaag gtcttcagta gacaagtttg
    11341 ccattcgact ttctacttct tgtttcggac tatttttaac gatttgacag ttaacgacct
    11401 catcttgact attgtacaac ttcgtttcat taaaatttgc ataaaaatat gggacatctc
    11461 ctttataaag atcacacttt tcatatggca cgatggtacg aaatgattga aaatcttcat
    11521 aggagtcatt aaaaaaagac aatactcgtt ctctttctga aaactcccct aaatactttg
    11581 ggtgaagtaa tgactttaag aaactcgtat atatataagt gggtctcgtg acgatccgga
    11641 caggaaagtc tgggaactga ttaatgattt tgctaataga aagatagttt tccctaaaaa
    11701 aggcatatac atgttcaaat cctttaataa attccttttc atatccaaaa atctcaataa
    11761 tctcattttg atagactggt aagttgtctc cccttgtcat caatgtaggc accttttgaa
    11821 gggccagatg atccgttccc ttatacatca cttgttcctc gtcatacgac tgattctcta
    11881 cattcgaaag cgcatataag tgcattattt tcgtctcttc cggatatgtc gtatgattta
    11941 aaaaaagtga tttataaact gtccgattca ggttatctag aaattgtttt ggtttttcta
    12001 tctcatcaac gccgttaaaa tacaagttcg gttgaaataa cgtttcaaga tctattaata
    12061 ccggttttga tccatgtgcc attatatttt cataatgaaa atcagagcct tgaaacatat
    12121 aaataaatcc tagatgcatg cctaattctt tatagaaaac ctctgcctct tgtttttctt
    12181 tcaaaggtaa tggttctata tattcctgcc aaccgtaatc acctctatca catgttctca
    12241 ttgtttttaa attggtttga cacgtttcat taaaaaaaat aataatgtct tcgtataagc
    12301 agtcgacggt tagggatctt ggtttatata cgagtgtatt ttcttcacat tcgaggatag
    12361 ctactgaatt tccatctcga tgtgtatcac ccatatcaat ggatgccttt aatagatcac
    12421 ctaatgttat cctcagtttt ttttctatat atgtatggtc attttgatag cgttgaatga
    12481 tttttatatg attatggaga aaattatctt caatagaagt gatcatttca actaatacag
    12541 ggtatttctc taagatggcc tcaatattat tagggtcacc caacaaattg ttaaacgctt
    12601 tataatattt cgtatcatcg gacggatcat acttctcaaa tgtattatga aattcgtaaa
    12661 taaccatttt agacatgaca ttaactattt ttcgtttata attgactagt aatgatgcaa
    12721 gcagagattc tttttgaacc ttatcatctg gaagcctgtt tattgcttca gtgacgcgtt
    12781 tttcaaaggt tgaaacaaag tatgagaaaa aaggaataaa aaagtcatct ttattaaata
    12841 cgttattaaa ctctgtgata ctttctttta ctatttgata gcttgcctct tctacatatc
    12901 tatccacgtg agatgtcccc tccttctttc aatagtacag ccttttaaat ggttatcggg
    12961 tgtgataagc atcacacccg atattcatta agtatctaaa attagccatt acacggtttt
    13021 actactgaag cgcattgtgt tgttggacaa gcagcagctg aaatcgggat tgtgattgtc
    13081 cacgttgcag gttggttatc attagatcca ccagcaaggt tcttaagctc tgtttcagaa
    13141 atttcttcaa ttccgttaac tcttttcatg ttctcacctc ctttcaataa aacgaacctt
    13201 caatcaggat attagcggcc gttatctctc tcctaaatag atttaactct tctttctatt
    13261 ttgagtcggc cgttatacaa acggttatct gtgatatagg ttatactaat tgttttttat
    13321 ctctcgactt taattgaatt aacatgccat tgtttaattc ataaatggat tcatactcgc
    13381 ttattgaatc tgtacgatgg gtgatagaaa ccacggtcat atctctttta tataagttaa
    13441 acaatatttc tttctccgtc gccttatcga ggttgcttgt cccctcatca atgagaagaa
    13501 tttttggatc tttggctaga actctcgcaa tagcaattct ttgtctttgt cccccagaca
    13561 ggctgacgcc attttctcct attaccgtgt gatagcccat tggaagacgt tcaatatcgt
    13621 catgaataca tgcatccttt gccgcttgta ttgcagcatc atcagaaact aaatcgttga
    13681 aatacttaat gttattcata atggtttcat taaaaagact cacatcttgt acaataaacc
    13741 caatattttc ccttattttc attaaattaa tatccttgat gttatgagga ccgaagtata
    13801 tcgagccttt tgtagctgga taaagacctg caatcagttt gaatagcgtt gattttccac
    13861 ttccagtttt accgatgagc gttatcttct cttttggatg aatgactaaa ctaatatttg
    13921 aaagaatatc ttctccattg tcatagctaa aatgtacgtg ctcgaacgta atatcatccg
    13981 tagcaggatt aaaggttgca tgactttcaa cgttattttg ttcatcttct tcttgaagaa
    14041 catattccac tcgatcgacc atttcttcaa ccatcttgac agattctaaa ctaccaataa
    14101 tcgaacctaa tggtgccata aatcttcccg caattgtggc aaaagcaact atggtaccaa
    14161 tcgtgagccc gttttgcatg ccaatcgcta taccgataat taaaacaaat aatggtaatg
    14221 ataaattaat agaattcgaa actcctccaa gtaaagccga agtattcatc ctttttgaaa
    14281 aatgaccgat ctgatcattg aataattgat tcattctcat ttcgatcgat tttgtatctc
    14341 ctacggtttt gataaatgtc atagatctca atatttcaac gagttgactt tgaaaattgg
    14401 cttggctgtt tacttcttgt tttgtgaaca tttcaattct cggcaataaa aatgtggtga
    14461 aaaacacttg taatccagcg cctataaata ctagcaatga taatgttgga gaataataga
    14521 gcataactcc gcaaaaaaca attaataagc tgatatctaa aataagtgtt gaagctaatc
    14581 ttgaaattat ttctcttata actgctatat tattaatcct tgtggcaata tcacctgaag
    14641 aatttacttc gaagaaattc ataggcaaag aaaatatttt tttaataaat tgattcgtta
    14701 atcctttgtt aatacaaact tgaagcttga ttatccaata cattctgaga attgatagac
    14761 caaaaaatag gatggtcacg catactccta atatggctaa caagtccaag cgtatagcgg
    14821 tttgtttatt gtccataaaa gcgtcaatca catattgcgt gagaaaaggt gtaattaaat
    14881 tgagaaattg aaaaacaaat gaaaggagaa taatgtaaac gagcattttc ttttcttgaa
    14941 gtaaatattt cctaatttta ttaactaagg aaacaccttt taacttagta tgagagcgtg
    15001 ctgcgtcttt ctttgtaagt ttaatcgcaa ctccgctata atctcgttca aattcttctg
    15061 ctaaaatcgt ttttctacct gcggccggat caatgatagt aatagtatta tctttaattt
    15121 tttcaataat gacgaaatgg ttgtttttcc agtgaacaat catcggacat ttaagtgcat
    15181 tttccgctat tttttccgtt aaatttaggg ctttaaaagc ctttaaatcg taaccatgcg
    15241 tcttcgccaa agtttttaga taaagtaaat cagtgccttc acgtcctatc tgcttcctat
    15301 cttgttttaa ctttcttgga tcaacacggt aaccttcttc ccaactcatg atcatcgcaa
    15361 agcatatgat gccacaatca taattgcttt tttgaagaat cactggtatt ttctttttta
    15421 acaatttcat aatatgcacc ctttggctac tctattttat cgagtttcaa actcagaata
    15481 ttcggaactc gttcatcaca tgcaaagagc gctccataga taatcccagc cattcctacc
    15541 attaaattcg gggtttctac ttcccttcca acgccacatt tatagccttt ctcttcacca
    15601 atttgtaagc tttccaacat taaattttgg gccatttcga ccacatcagg ctggtttgtt
    15661 tcccgcccat aggcaattaa tattgcggca tttcctatat ctccgtgaca taaactatgt
    15721 tctcgcccaa aaccatcata gaatatatta tccctcgcca tattcatatc aatttcagct
    15781 tgctgggata ttttcttctc atgagaaacg gcgagaccta accgactcaa taaaatacct
    15841 ggagagccat ggcaccaagc agaagtggct gcttcttcaa tcggtttcct tcgatcaatc
    15901 cagttgtctt gaaccatttg attattctcg taattcatcc ctttcataat cacttcagaa
    15961 atggtttcat cctttaagta attattaagc aatgaaagcg aatatatgat gccggcattt
    16021 ccatgagagt agccagttaa aggctgttcc gctacaccaa cccatgagat ctcattctga
    16081 ttaatgtcta ctgcattgtt cataatatgt tcgcagcatt gcgctgccgt ttttaaaaat
    16141 acatcgtttc tcgtccactc ataacaactt attaaaactg ttattgcgcc agctgcccct
    16201 ccgataatgt cgaattcttt atcctgttca attagtattg taatcttatc tgttaactcc
    16261 aatgaaagtt ctttatattt cttttctttc gttgcaatgt aaaagttcat caacatatat
    16321 atgatagagg agactccaga aaaagcacca acggagatat gtgtttttct ttcctctgat
    16381 agctctaaat ctttaaatct aacacttata tcctctacaa tgtctattgc tatatctaag
    16441 tacttttgct ttttagtcac aatccataat gacagatacg tcatcgccat gcccgacaac
    16501 ccgtcataca ttgtgtcccc catcggaacg agattccatt gaatttcctc tacacctaca
    16561 ggggttgaat ttagccagga atagttaggc ttaccattat tagtcccttt aaaagattgt
    16621 gagtagatat gctctgctat ctcctcagcc tttttaataa aatactgctg ggaatgaaat
    16681 ggcttcttgt agtcctcagg attttttgta acaaatttct ttaattctct ctgtctgtca
    16741 tctcctgatg ccagcatcga taaatcaatg acttctagtt gaaaatctaa ctcttctttg
    16801 cttaatccat ttattttctt ccgcacaagc tcaaatgggg aatgtgtgaa atagtctgct
    16861 atgactttgt ttctcgacgt gaacaagtct ttagaatgaa taggtaattt aaaataagga
    16921 atatcatcat ttatcaaatc actgtattca tgtttggcta aaggaatata attctcattc
    16981 acttttattt cttcccaaat ctttgctaag tagacctcac gatcaatcgc attatggaga
    17041 aaacgagggt gtaaacttaa ctcaagaaaa gaagcatatt taacagttgg ttttggaatg
    17101 aatcgtacaa atacagcgtc cgaaaagtcg ttaataactt ttaagatttc ctcagaatat
    17161 gaagagatag tttcaaacac cttagcgaat ccatctttta tttcactaac ataatcttgt
    17221 gcataaacaa actcaccatt ccatttagga tgattggatg aggagtccat gctgacatat
    17281 tctctctcaa ttttcatatc atctttgtta ggatttttaa tctgcggaag cttgataaat
    17341 gattgcactt taccttttcg ccctattcca ctaatatcaa cattttcctt accaaagaaa
    17401 aatggaagta accctaacgt ccttaccgaa gaatttaatt ttttttcagc tttcacatag
    17461 gcactttctg tatcggtctt taaatgttca tatggaatat ggaatagaga ttctaaatct
    17521 actagtactg ggaaactacc attggcaata atgttttccg agtgaaaatc tacggcgttc
    17581 agtgtatata aaagagctat ctgtccaccc attctccgat aaaagttttt gatatcttgt
    17641 tcatctgaac attcttcata atggataaat tcaacccaac cgtattcttt tctacttatc
    17701 actttaggag tagagatctg gtattgatca ccatcaacct tttcattgag ccaaacgact
    17761 attttttcgt aaagtaaatc gatatttaag ttgcgtggtt tatatatcaa gacgctattc
    17821 tctaaaatga cttgggctac tttcctacca tccgaatgcg catctcccaa tcctacttct
    17881 atcgtttcaa tttgttcaat ttcagtttga ttagagagtg ttgcggaaat ttccaattta
    17941 tcatggtcgt atctggttag taattcagtt ataaactttt taaattttct tatctcattg
    18001 gctataattc ttaaaagacc tagataaaaa tcaaaaaatg aatttaaata ctcggaatcg
    18061 tttaaaagga tatgattata atagcgatac ttctcttctt tagtattccc ttgtaatttc
    18121 ccattttcgc gatttatatt taagtccaat acaagcgttc tataagaagt ttttaaaatt
    18181 tgcttttgaa actgagtaga gacatccttt aaaaattgac tttcatcttt taaattatgt
    18241 ttggctgctt gatagcgatt tgaaaccgtt aattttttta taaaatagga ggtaattttt
    18301 aaagcaaatg tatgaaataa aatatcctcc gaacgctctt taggatctat ttcttgattg
    18361 gctatttctt gctttaaacg ttgataaacg ttcaatttaa atgtatattt atgtaaatca
    18421 gtgttataaa ggcgacggac tctctctaaa gaattaatag ataaaacatt atgtaagctt
    18481 tctgtggcga gttgtgtatc acctttgtat acaatgtcaa tattacgatc taagaggctt
    18541 gcgtcttgag ccgctccgct ctcctttttc tcgccgcatc ttaagatttt cagcatatta
    18601 ttcataaatc tatcaactcc ttttaatgaa gaagggggaa gcccccttct atcgtctttt
    18661 gcaatactag gtggatcttt tttgctatga tgtgtatgga gcctaagtat gatttcttac
    18721 tagcaccaac atgtgtgagt tgggcaaatg ctgcattccc aagtaatggt acaatatttc
    18781 ccatcattac cttgggaaat cccttgaacg tcagctcctc cgctaacaga attcaaagag
    18841 atctcttcca tctcttctgc tacatttcca gcaatagcat atagctcttc catctttatc
    18901 acctccttta attatttaaa aactttacta ttttctgtta attcaacttt aatagattta
    18961 tagagttgtg tcagcgaaaa tattgcttcg cctatacgca tttataaact ggtttaccga
    19021 agcatatttt gcgtcctttc actaaattaa ccttttcacg ttaattactg aatgttgatt
    19081 agctgcatct gaaataaaaa cgtgccccac ctacctctcc ctcgattatt tgatgaacga
    19141 caaaaaataa cagcaagata ccgcagaaac acgacatctc gctgctgtta tattaaccat
    19201 tgtatacact agatacgcta aaaaatcgtt cactctcctc aaaggtaaat tcatcgttcc
    19261 aatgatttta cttgattaaa cgttacttaa tacctttttt aaattacatg gcagactagc
    19321 tagggatttc ttttaacgta ataagcgaat acttatttgc cttacttaaa gcctccgttc
    19381 tagattttac gcctaactta tggtaaatct ctgtcaacga atattctact gctcgttgac
    19441 taataagaag tctatcggca atttcccgat tcgttaagcc ttcagaaata gatagaataa
    19501 tcttctgctc tctttccttt aacgtaatat ctcttaaacc atgtttagta gtgagttcag
    19561 cttttggctc tgttcgtctt agctgcttaa acagttgagt gggaagaact gtttcacctc
    19621 ggacaacaca ttctatcgta ttaatgaccg tttcatatga ggcttctttg ctgatgaatc
    19681 cagacacccc aatttccatc agtacattga aatactgaga tatatcgccc cctgtaaaaa
    19741 taaggattct tttatcagga tcattcatta aaatttgttt tgataactca aagccattta
    19801 aataggacat gaataaatcg agtagaataa catcgtaatc aacgtttcca attcgttcaa
    19861 gaacatttct actatccgtc gcaatatcta ctgccattgt tttatttttc tccaataata
    19921 acttgagacc ttgcacaaca catacatgat catctaccaa aagcatattt atcataatat
    19981 ttttctcctt aattattatt catctcttta tcaacaagag atcttatcta aaaagtagaa
    20041 acatatcact ctatgaatga tttagcatat catgtacagg ttacttcagc ctgtactaag
    20101 tcactttgaa gctaggttca gagaagaaat cttccctgtc cctttcacga ttgcgttgta
    20161 taaggtatct cactaaaatt tccataccga ataaactttt tattcgtata aatctaattg
    20221 gagctaataa aaataaacat tgcaaaacta ataatataaa caataaataa cccaattacc
    20281 catttagtag acttacgtcc tttattcaat atacctcctt tgagtccaaa gttaagaagg
    20341 ttagcaataa aaactgccag cgctccaccc aatgaaataa tggcgataat aaatgttatt
    20401 ttttccatta gaatccttcc tctctattga atgtatttaa cacttcatag aatgtgaggc
    20461 tgacgtttaa taccctcctg atttcgtacc atcaactcat tctagtcttt tgcgaatatt
    20521 tatataatcc taataaggag gtcgcaatat aagcaaaaaa gatagcactt ccccacaatt
    20581 ctagctgagt tctaccgtat cccatcgatg aatcaaaaaa ttggatactt aagcgatagg
    20641 caaatgaaaa agggaaaata attgaaaaat cagctccaag taaaatcgtc gtaacgaaaa
    20701 taaatgcaac acctgcaatc actacgctga gaatattcct tgtcataaac accaataatg
    20761 ccgcaactgg aataatcagc aatattaaaa atgaaaacag aaaggaggtg aaaaagtggg
    20821 taacaaccgt cattaactgg atttctgttc taaataatac ccacaaagtc acgagatgga
    20881 tcacatgatt taagatagct gtccctagta ataatataaa ggcagcaatc atcttcgagc
    20941 ccattagact gaaattatga aacggatacg agatccaatt taatgtcgtc ctgttttgaa
    21001 attcagtgta aaaaaagaag ccagtaaaaa tgaatacaag tgtagggaaa agaatggcat
    21061 attgattaaa cacaaaataa tagtatttac ctgcatccat ctcgccactc atcattaaca
    21121 tgccagctgt attgatcaaa aaaggtaaaa agctgacgac taaaataaca tacaccatct
    21181 tcaaacgttt taatttggtt aattcatttt taataagtaa gttcatattc ttcacctcta
    21241 gataatagct ttaaatataa atcttctaat gaaagctcga atacttctag ttttataact
    21301 ggaatcttat attgttccag taacaccttg acctcccttt gtccaaaggg ggacacaaat
    21361 tctacgtaat cttcttcttg aaatatccgt tgtccatgaa gttctgtcat tagctctggt
    21421 tgtaaatcaa aaggtgtact cagcttatac atataatttt ttgtccgatc caccatattc
    21481 atagccattt caaaaataat gttgccatta ttcataaaaa tgatgtcgtc cgccatcaaa
    21541 tcaatttcat tcagtaagtg actggaaata atcaccgtcg ttcctttact tgctacctct
    21601 tggataagca tctctcttac ttcctttatt ccgtgtggat ctaacccatt tgtcggttca
    21661 tcaagtaaca acagttttgg ctgatgagcc atggctctcg ctatacctaa ccgctgtttc
    21721 atacctaatg acgtttcaga aaataacttc tctttatgtt tgtaaagacc aacctttttt
    21781 aataaagaac aaatgtgggc ctctgacaaa tcttgattta aatatctcat atgaagaagg
    21841 agattttcca tcaatgttaa attgtcataa aaaccaggaa attcaataat actgccaatc
    21901 gaacttatta aactcttatc tggatgatca tataaatttt gtccttgaaa agtaatggtg
    21961 cctgacgtcg ggcgaaaaac acctagtaaa acttttaaaa gtgtcgtctt tccagcaccg
    22021 ttagggccta aaaggccata aatctttccc ttttcaatat ttaagttgac ctcactaaga
    22081 accgttttct tttttatttt caccgtcaag tcttctactt ttaatatatt ttccatataa
    22141 atgacacctt accttcctct ccatttataa gttaagtata aacaggcaag gttaaattct
    22201 atcctttttc taggttaaaa atagattaaa acaccgtccc ctgtagccca aattaaaaaa
    22261 agtgtgtatc catcttgctt acggatacac atttaacgta catgttcata tacatatcaa
    22321 gttagagact cagttaacct tcactactca ctgcctgtct ttttaacgat aggctgaatc
    22381 gtaattgtcg tccctagtgt tttatcagaa accgttttct ttaagttcat ttgctgcaac
    22441 atcatatcta caatcgatag tccaatcccc gcaccactta acttcgaagg cgttgtcatg
    22501 cccggaccgt gatcgcatat ttttaaaaca gaggtacctt gttctctcat cgttttcaca
    22561 gcgatatact ttccttccct tgcatgccgt tgcacatttt gaaacagatt atctagaacc
    22621 ctccgcagcc atgtttcatc aacttcccat tcaatcggca gtgtcaaatc tacctcaata
    22681 tcaaacccga gctcttcaaa aataggatac caagcgatga tagacgagcg gacgactgtt
    22741 gtaatattca atgattgttt attaattggt agtttccctt cacttagtac agtgtacgac
    22801 gacaagttat caattagttc agccataaag ttaacctttt cattgataat tttaagtgat
    22861 tcgtttgctc tcggatttaa ttcgtactga tttaatttat gggagtgacc atttataata
    22921 gacaacggtg tacgtaaatc atgcgataaa ttagcaatga gtcgcttacg aatgacctcc
    22981 tccgtttttt ctttttctct actctccttt aattgcttta ccattctgtt aaatgagtgc
    23041 tctaattgac cgatttcatc atccttttct acgttcattt ccgaaggaac gagctgattt
    23101 ttactgacct ccatgttttt ttgaattctc acaagtcttt tccttaattg gttaaagaac
    23161 acccaagaaa tgaaaacaaa gagaaaccaa attaacccta aagcaataaa ccagacaaac
    23221 gaataacggt ctcgaagaac ttcccactct gatccaatat aagcttgagg aattctcagc
    23281 aaggcatagc cactattttc cgctccttct acataagaaa atgttgtaaa ataatcatcc
    23341 tcttgttctg ccttcatata tgcaatcgtc tcagatacac gccatttttc atttaggtcc
    23401 tcggtttgac cgtcagacat gagcaaatct ccttcatcac tgagccaaaa aatcatagat
    23461 tcagggaaca aatcaatact ttttagatga tctatcacat catcgttcgc cattcctgtt
    23521 agggaagtga cttgcttgtt ccattcttct tctatttcat cctgttcata aaactcttca
    23581 gacgtaaaat tgcctaactg cataataacg gaatagtaaa ggaaattcac acctaaataa
    23641 gaaatcggaa agataaaaag cgacaacaaa atgatcatga tatactttgt tgatagtttc
    23701 actgtttcac tctataaccg agtccgcgaa tcgtttgaat gattttcggg tcctctggct
    23761 ttttctcaat tttttgtctt aaataacgga tatgtacatt taacgtttta tctccctcaa
    23821 tatacggctg gttccagaca ttggaataaa tttgttcttt cgttaaaatt tgatttgtat
    23881 ttcttaataa ataatgaaaa attttaaact gcttttcagt tagaaaaatc tcttcattcg
    23941 tttcagtatt aaaaatctga tttgctttta aatcaacttt taaatggtca atatacacaa
    24001 cgtctaacgt tactttctca aatcgacgca gcaaaatatc aattcttagt agaagttctt
    24061 tcgggtgaaa aggtttagtt aaataatcat ccgcgaattc taatcctttg agtttatcct
    24121 cgatggccgt tcttgctgtc aaaaacaaaa taggaatagt ttcattcatt tcctttattc
    24181 tttgtcctac tgtaaaaccg tccaaccctg gaagcattat atctaaaata accatctcta
    24241 ccttatcaag gtaccgatca aattggttgc ctgattttaa ccatgtcaat tcataaccat
    24301 tatctattaa gttttgcttt actaaatctc ctacctcatt gtcatcctct atgtataaaa
    24361 tatgattccc catagtatag cctcctccga aacaataatt aaatgtgcgg atcatatctt
    24421 tccatcagtc ccttttaata cctttttagc ttaacatgat tttccaagct cgtgaatatt
    24481 taattagata tttgggagat gaccaaaaac ttccactgat tgaagcttcg ttttatgaca
    24541 gaggtaaata aagtattgag ctgtgcaggc ttccattatt ttaaggactt cagaaggaca
    24601 ttcctctact taaaggcatt caactgttga gtcacgttga aattgcacct cccgtctatc
    24661 taaatttttc tcttctctct attttgacac gggcgtttta ggggcgatca tttggaaaaa
    24721 ataggtttac cattatggaa gactaaccca cgttatcact ttaagagcgg tgtatgttta
    24781 tttcttgtca acttgaaaaa aattgaatca tgcaacatta tcaagctaaa aaagcgtcag
    24841 gaaagaaaat tgtccttact gacgcttttg atttaataga tggaagaatt caacatctaa
    24901 ataaatatat ttattccctt ttcatgaaat accattataa tgtttactaa ttataatcta
    24961 ttacaaatca ccaatgatca atatatcccc catccgttta ttaaagttca gttcccaatg
    25021 ttactagcct taattcatag tttgtccgtc tctttctgga atatcatttt ttcaaatgac
    25081 aaattaatcc gaactattta atttctcatc tagaacgaga ttactttcct actggtctaa
    25141 cccatatttc catatatgcc acatccgagt tagttttata atatttttct actgagaaag
    25201 ggtgtgttgc caactgatgg ttaacaagcc acgtgccaaa aaggtaattc atcgctttac
    25261 ttaggactga agttgttaat aactggaagt tttctgcctc aaaacaacat actacatact
    25321 ccccaggggg taacgaccat gtcacaaact ctccagcatc ataagaagta gcgctcatct
    25381 cacccccaac aaaataagta aatgtatttt gtccatcatc acccatagaa gaaacgccta
    25441 cttctttccc atctggctta agtattggaa ggtgtgatac catgctgtga aaggtatccc
    25501 ataattgacc aggctcatca acaccagtgg tttctccaat tggtgtttga gagatcaaaa
    25561 cttgaccgga caaaccgata tatgtctcag ctacctcaag tgtctttcgt tttatttcta
    25621 gaaccatgct gtctgtaatc agaggaacac ctaaatcaac caccgtatac tttaacagta
    25681 attcaggttt cataatatga ttaaggtgaa caggatgagt acggtattct tctggtgtta
    25741 tgccgtatgc ttccttaaaa gcacgagtaa acgtttcgtg cgatgaaaac ccaaaatcta
    25801 atgcgatgtc tataatcctt ttactgagat ctcctaattt ttcagacgct cttgcaagac
    25861 gtcttagctt tatatactcg tttacagatc tcttgaccaa cctcttaaag agacgttgaa
    25921 aataaaactg tgatagggcc gcttttttgg ccagtccttc aattttaatt tcttcagaca
    25981 agtgttcctc aatataatcg acagtttttt gaatctgttc ccatgagtgc atgataagca
    26041 cctcctcaca aacaagataa cacgatattt gcccatatcg cttgacaacc aatgccatct
    26101 ttatgagatg tggtattatt tttgagttca gcatttttat agtaaacata agagatgatt
    26161 aagccacaca gtttcccatt cctctaaccc ctcttctttc aagccagatt aatttaagct
    26221 cacgataaac tagttttaat actcagttaa catttctgac tgtgccttct aataaggaag
    26281 catacttact gcggtcatgc tttctatttg acaaaacata caagcattta ataaacttcc
    26341 tttgcaggtt taaacaaaat taactattct cataaccata tacaattact attgcaacac
    26401 ctaaggagga aaaatggcag agcaccgatt tcatttaaaa gcaaactggc ctggtttacg
    26461 taatgatgta ggtgaaattg aaacagcaaa cctattcaca aaagtgtcta tcccacctga
    26521 aatggacggc ccagggatag gaactaaccc tgatgaaatg ctgcttggtg cagccgctac
    26581 ctgttacatc attacattag cggctatgat ggaacgcagc caattagata aagtgagttt
    26641 aacgatgaca tcagttggca tagttgacgt taccaacggt accattactt ataagaaaat
    26701 cattcaccgc ccagacatcg tattaaaatc tagtgtcaac gatggagatt ttaagctggc
    26761 agataagctt gctaacaacg cggaaaaagt gtgtatgatt agtcgagcac ttcaagggaa
    26821 tgtaaccatc gatgtatatc caactattag tgctgccagt gagtgaactc gtatagattt
    26881 taaaaaaatg ttgcacctca tcgtaagaac aaacactact aaaaaatgct gatggagaat
    26941 tatctttatt acaatataaa catttatagt tttctcacat accctttgca tctgaactaa
    27001 caagatacct atctttatca ttaatagtgt tgaaaataaa tacattaacg ccttgactaa
    27061 acaacagctt aataacaaac ctattgtata ggatggacac catttaaaag ctagctctct
    27121 cactttaaat accgcttatg ttgatttcaa agccatctcc taacactctt tttgtaagca
    27181 cgataggttt caccgaattt ttcttccagc attttctctt cgaatttgat ataccaaaag
    27241 tttgtaatta taaaaaatcc caccacgaca atgaaaggag agagacttcc caatacaacg
    27301 gcaaggccta ggagcattat caaaaagcct aaatacattg ggtttctagt ccttttatat
    27361 aaaccttccg tcactagcaa atctggttca ttaaacgtca tttctgttgt tccttttatt
    27421 ttaaacaatc gggccccttg taaagtggcc cgccctccta ttaaaattag aagaacacca
    27481 aaaaggttgt acggaacttg aataaaaaag tttattggaa atagaatatg gcctattatc
    27541 attgatacga tgcaaagaat aaataatact ggcggtaata aatagctcat aaagcccctc
    27601 ctagtcgctt attctagtta agatagtcat tttcttcaaa ccagctaaca gtatcagaga
    27661 gtgttgccgt aagaggtctg aaagttaagc ccaattcctc ttttgccttc atagaagagt
    27721 attctttttg gtttctcagc tttttaagtt catctctttt tggtagtggt gacggttttc
    27781 cagttatttt tgccctcatt gtcatcatgg cagacattaa catgattagc ttaaaactag
    27841 gtgtacgttt agggataggc tttcctgata tgtcagaaag agcactcaca acgtccttta
    27901 cttcataaat tttcccacca ataatatacc tttctccatt cctaccttta tcaattgcag
    27961 ctacaattga tttggccaca tctctagcat ctacaatcac cgttttcaca gggaggatag
    28021 cgggcagact ttcctttaaa aaacttatta caaattcccc cattcgtgtc accccatgat
    28081 catttggccc catcataata gcaggaataa cagtgataaa tcttaaatta ggatgttttt
    28141 tattaaatgc cattgccatt ttttctgcct caattttgct tttaaagtaa gggttattag
    28201 tcgtctcgtc gtaaggtgta ttttcatcaa ctacctcccc actcgatgta tctaacactc
    28261 ccgttgaact aacgtaaata atgtgacgca ctcctctttc gtaagcccct tgaaataatt
    28321 ggtttgttcc ttttacatta atttcgtata aagcgttatc tacattacct ttcttaaaaa
    28381 attcagtaaa gtaagcacct gcatgaatta aaacatcacc cccttctagt tcagatacaa
    28441 agctagtgac atctcttaaa tctccttgga taatctctac acctgcgggg attaatcttc
    28501 gcgctttttc caacgacctt gctaaaagtt ttacttgatg atggttatcc agaagctcct
    28561 taacaatatg actacctaac aaaccagttc ctcctgtcaa aaaaa
//
