LOCUS       NZ_CP019724            22619 bp    DNA     linear   CON 01-JUN-2024
DEFINITION  Streptomyces pactum strain ACT12 chromosome, complete genome.
ACCESSION   NZ_CP019724
VERSION     NZ_CP019724.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces pactum
  ORGANISM  Streptomyces pactum
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8550793)
  AUTHORS   Xue,Q., Yan,X., Jia,L. and Yan,H.
  TITLE     Streptomyces pactum ACT12 Genome sequencing and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8550793)
  AUTHORS   Xue,Q., Yan,X., Jia,L. and Yan,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-FEB-2017) College of Life Sciences, Northwest A&F
            Unversity, No.22 Xinong Road, YangLing, Shaanxi 712100, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: AUG-2016
            Assembly Method                   :: SMRT v. 2.3.0
            Assembly Name :: version 2.3.0 of the PacBio Single Molecule Real
            Time
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002005225.1-RS_2024_06_01
            Annotation Date                   :: 06/01/2024 05:58:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,315
            CDSs (total)                      :: 7,221
            Genes (coding)                    :: 6,992
            CDSs (with protein)               :: 6,992
            Genes (RNA)                       :: 94
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 229
            CDSs (without protein)            :: 229
            Pseudo Genes (ambiguous residues) :: 0 of 229
            Pseudo Genes (frameshifted)       :: 84 of 229
            Pseudo Genes (incomplete)         :: 195 of 229
            Pseudo Genes (internal stop)      :: 15 of 229
            Pseudo Genes (multiple problems)  :: 62 of 229
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:20:20
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8142796
            Orig. end                         :: 8165415
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP019724.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Northwest A&F Unversity.
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22619
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="32"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22619
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22619
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12619](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12619)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            complement(230..1396)
                     /locus_tag="B1H29_RS35310"
                     /old_locus_tag="B1H29_35390"
     CDS             complement(230..1396)
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0004813 - alanine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006419 - alanyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018522819.1"
                     /locus_tag="B1H29_RS35310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_35390"
                     /product="alanine--tRNA ligase-related protein"
                     /protein_id="WP_055420109.1"
                     /transl_table=11
                     /translation="MDTERIVRTFVEYYEELGHRRISGSTLLPPPGDTVLFTTSGMHPI
                     TPYLEGRPHPLGRRLVNVQRCLRTTDLDEVGDSTHLTVFEMLGTWSLGDYGGSRSLDWG
                     YRLLTEGLGVDPGLLHATVYGGGDQVGPDTASLRRWQEHGVPVELTVEDNWWSNGPVGP
                     CGPDSEIFLWTGDTPPRSTPTRDERWVEVWNHVMMHHRRLDDGRLVPLPQRNVDTGLGL
                     ERLASLLQGKSSVFECDVFEPWRRVVPSLWPLDEPSLRLVHDHLRSAVVVVGDGVLPAS
                     TGRGYVLRRLVRRVLTVLWRDDPSRSLGDLPDELVSHTLDRFRQEGDPGHVRRLLVEEE
                     DRFGRLMERGRKVLARLRFRGPLGDDDFHYLHDTHGLPRDLVMRLREE"
     misc_feature    1375..1389
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.14"
                     /tool="antismash"
     misc_feature    complement(1613..1624)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 16.87"
                     /tool="antismash"
     gene            1805..2119
                     /locus_tag="B1H29_RS35315"
                     /old_locus_tag="B1H29_35395"
     CDS             1805..2119
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020131533.1"
                     /locus_tag="B1H29_RS35315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_35395"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_199832402.1"
                     /transl_table=11
                     /translation="MADDLFKALADRTRRTILDELAEKSGQTLFEICSRLSMKHRLGIS
                     RQAVSQHLAVLEAAGLVETRREGRYKFHELNTAPLRQITERWLVPDTMPDTSAPEESTP
                     "
     gene            2116..2508
                     /locus_tag="B1H29_RS35320"
                     /old_locus_tag="B1H29_35400"
     CDS             2116..2508
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474119.1"
                     /locus_tag="B1H29_RS35320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_35400"
                     /product="VOC family protein"
                     /protein_id="WP_055420107.1"
                     /transl_table=11
                     /translation="MKIHLTSVFVEDQAKALHFYTEILGFVKKHDVPVGERDRWLTVVS
                     PDEPDGTELLLEPAGHPAVKAYRDALVEDGIPLAQFAVDDVRAEYERLRGLGVHFTQEP
                     LEMGPVTTAVLDDTCGNLIQIATQPR"
     gene            2792..3622
                     /locus_tag="B1H29_RS35325"
                     /old_locus_tag="B1H29_35405"
     CDS             2792..3622
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389684.1"
                     /locus_tag="B1H29_RS35325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_35405"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_055420861.1"
                     /transl_table=11
                     /translation="MFRKRPAPDGEELLARLASLTTQARELAELRRSQVELAIALQRDM
                     LPADLPAVPGFHLAACYSPAYAGLNVGGDWYDAFVLPDGRLGLSVGDVQGHAIDAAAFM
                     GQIRVGLRALASVTSEPGDLLARTNDLLLTLDKDLFATCTFMRFDPVTGVLESARAGHV
                     PCVWATADGKAEVSEDEGGPPLGVLEGAEYPVTRYRLTTGGVFVLLTDGVVEGPSLSVD
                     EGLERVVRLAGVAAVAGMDAHSLAAAVLKNAELVGHEDDAAVLVVGHDGRAVTP"
     gene            3673..4662
                     /locus_tag="B1H29_RS35330"
                     /old_locus_tag="B1H29_35410"
     CDS             3673..4662
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027126.1"
                     /locus_tag="B1H29_RS35330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_35410"
                     /product="MASE1 domain-containing protein"
                     /protein_id="WP_055420106.1"
                     /transl_table=11
                     /translation="MAAVVGIRAWPRPVVFVGETLLVSVCYYVAGRLGLSQQLVADGAV
                     VTPIWPPTGVAVACLLLFGLRCAPGIALGALLVVASLTAPRLSAAGIVLGNTIAPVCAL
                     LMLRAVGFRVSLSRLRDGVALVFLGALTAMLISSGVGVGMLVLTDKLAADDFWLVWLAW
                     WVGDAMGVVLVTPLLLLLHRARRSPPSGRWGEAVGLALVVCVLVPVVTYSSISVLFLVY
                     PLLIWAALRFQLAGGMPCALYASVMTTVAARDEAGSFGALTDIETMMKLQAFNGTLGLT
                     ALLLSAVITEQINTRRSVERACHELVEALQHLNAGGSGNTGPPGRGAG"
     gene            complement(4686..4895)
                     /locus_tag="B1H29_RS35335"
                     /old_locus_tag="B1H29_35415"
     CDS             complement(4686..4895)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007262121.1"
                     /locus_tag="B1H29_RS35335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_35415"
                     /product="hypothetical protein"
                     /protein_id="WP_055420860.1"
                     /transl_table=11
                     /translation="MPTDPVARFLAALDPDHRDAVSARPREEQERLAEDWERELSTDTD
                     LDTLDELSPSAAEAEAARRVLGER"
     misc_feature    complement(4950..4964)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     misc_feature    complement(5105..5120)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     misc_feature    complement(5167..5181)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
     gene            5437..6036
                     /locus_tag="B1H29_RS35340"
                     /old_locus_tag="B1H29_35420"
     CDS             5437..6036
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019328268.1"
                     /locus_tag="B1H29_RS35340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_35420"
                     /product="response regulator transcription factor"
                     /protein_id="WP_055420105.1"
                     /transl_table=11
                     /translation="MVRVLVVHDATLLRSALVQLLRSADGLEVSSMPSRGEDPDGNDLP
                     AEVCVVDGDCLEGSPSDAGPAPFWDRCGARLVVLAAPERPGVLRKAFDAGALGFVDKDA
                     SSERLITAVHTVAKGERFLDERLTVALLRASEMPLTARELSVVFQASQGASVAEIAACL
                     HLSRGTVRNYLASAIRKVGARNRVDAIRIVQNSGWM"
     misc_feature    5566..5568
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6077..7909)
                     /locus_tag="B1H29_RS35345"
                     /old_locus_tag="B1H29_35425"
     CDS             complement(6077..7909)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827682.1"
                     /locus_tag="B1H29_RS35345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_35425"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_079160647.1"
                     /transl_table=11
                     /translation="MTSTDERRAGKRRRGSGPGPLRRVGPSARRFLAGRKTVLVRLAGW
                     SLAESAQTFVVGYGVAQAVDRGFLAGDTLTGLGWLGVAACAVVLGAPVVRGVFAQLAGL
                     TEPLRDGLVRRAVDQSMARALSRPGGGDRAAVSRLTNQVEIVRDSFAGLVLTVRSFVFT
                     AAGALVGLFSLDPALLVVVLPPLAGGLALFLATLRPMAAAQRRALTADEALGDHVTRTR
                     GALRDLTACGTQPEAARSGARLVADAAAASRVLARWAAVRTLALGVSGQLPVLLLLVAV
                     PWLRDRGVTTGALLGAFTYLAQALLPALHTLMTAIGAAGTRLLVVLDRFTAPQAHPSVT
                     GAAPRTPLPGRAGPPQQGRSSLPPAPPPSRQVPAVELSAVTAGYGARTEPVLDALDLRV
                     EEGEHLAVVGPSGIGKSTLTRLVAGMFAPRSGVVRVNGRTVAGRSAAELAALRVLVPQQ
                     AYVFTGSVRDNLAYLRPDASAADVEAAVRDLGAAPLVERLGGLDAPLRPDDLSQGERQL
                     IVLARAHLSTARLLLLDEATCHLDAASEARAEAALARRPGTLLVVAHRMSSAVRADRIL
                     VLDGVRAAHGTHRELLERSPLYRDLVGHWSRTRA"
     gene            complement(7906..9630)
                     /locus_tag="B1H29_RS35350"
                     /old_locus_tag="B1H29_35430"
     CDS             complement(7906..9630)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019328270.1"
                     /locus_tag="B1H29_RS35350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_35430"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_234393143.1"
                     /transl_table=11
                     /translation="MPELLVLVCSVAAAAVAVVQPLVLGRTLDLLLHDGAAGRWLAASA
                     ALLVGEVLLDGLTALLTGRCTADWTASIRSRALSGLLHAVPELARPYSPGDVATRLTLN
                     ASDAGAAPAARAALAASLLTPSGALVALAVVDVWVAVCVLAGLPALVLVLRAFARDTGV
                     SVGAYQRVQSDIASRLLETMEGAETIAAAGTAARERERVLRPLAELGTLGARMWKLHGK
                     ALATGGVLVPLLTVAATAVGGLRLGSGALSVGELLAVCRYAQLAAGFGGAATLVGALVR
                     GRAARERTTTLERLPALSYGTRSLPPGGPGALELRGVRVQREGTEVLRADHVAVPGGLT
                     AAVVGRSGAGKSVLAAVAGRLIDPDQGQVLLDGTPLDLLTRSCLRAEVGFAFARPVLGD
                     RTVAEAVAAGPRTVSPHQVQEAIRLADAEAFVRRLPRAYDTPLADTPLSGGEYQRLGLA
                     RAFAHAGRLLVMDDATSSLDTATEHAVEQAQRRSPQAATRLVVAHRPSVAARADLVIWL
                     DDGRVRAVDTHRRLWEEAAYRAVFGTRENGVGPSPTEDRPDGRRGGRTAVLREGTRP"
     gene            complement(9837..9965)
                     /locus_tag="B1H29_RS35355"
                     /old_locus_tag="B1H29_35435"
     CDS             complement(9837..9965)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018849360.1"
                     /locus_tag="B1H29_RS35355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_35435"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_055420103.1"
                     /transl_table=11
                     /translation="MNLFEMQSMETPKEEAMGDVETGSRASLLLCGDSSLSVTTCN"
     CDS_motif       complement(9903..9965)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNLFEMQSMETPKEEAMGDVE"
                     /locus_tag="B1H29_RS35355_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9837..9902)
                     /prepeptide="core"
                     /locus_tag="B1H29_RS35355_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="28.10"
                     /molecular_weight="1941.2"
                     /monoisotopic_mass="1940.0"
                     /core_sequence="TGSRASLLLCGDSSLSVTTCN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNLFEMQSMETPKEEAMGDVE"
                     /leader_location="[9902:9965](-)"
                     /alternative_weights="1959.2"
                     /alternative_weights="1977.2"
                     /alternative_weights="1995.2"
                     /alternative_weights="2013.2"
                     /alternative_weights="2031.3"
                     /alternative_weights="2049.3"
     gene            complement(10001..12619)
                     /gene="lanKC"
                     /locus_tag="B1H29_RS35360"
                     /old_locus_tag="B1H29_35440"
     CDS             complement(10001..12619)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827685.1"
                     /locus_tag="B1H29_RS35360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_35440"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_055420102.1"
                     /sec_met_domain="micKC (E-value: 1.5e-240, bitscore: 799.4,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 2.9e-12, bitscore: 45.2,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4.1e-05, bitscore:
                     21.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKGYAVYCDADPHFYDAPHRTGPGTRAADTRYAAAGLPVPAGWQ
                     RGESGDWLALRPLDAVLPPQGWKIHVSACLENAESVLERVRHHCVERGVAFKFVPSRYL
                     LHQRNAKYADRAGSGKFITVYPADEEQFEHLVGELAALLDGEPGPHILSDLRIGAGPVH
                     VRYGSFTRRNCYDENGELRPAVADPEGVLVPDFRGPVFRVPDWVDVPAFLRPHVEARAT
                     VTLTDIPYTVESALHFSNGGGVYRARDTRTGAVVVLKEARPYAGLAADGADAVTRLHRE
                     RRALEQLSGLSCTPEVLDSFTVGDHHFLVLEYLDGKPLNTFFARRHPLIEADPDDRRLT
                     GYTEWALDVHARVERAVEEVHARGVVFNDLHLFNIMIRDDGRVALLDFEAAHRVDEPGR
                     QTVAHPGFVAPPGRRGTAVDRYALACLRLALFLPLTSLLALDRRKAEHLADVVARQFPV
                     DRAFLDAALDEIADASGRRPAARPATEHFVPVAPGDWPRSRDSMTAAVRAAATPSREDR
                     LFPGDVAQFATAGGGLSFGYGAAGVLYALAESGAERDEGEEQWLLDRTKEPPSGMPLGF
                     HDGIAGVAWTLDHLGHRARALDLTRLLLEHPFDDLAADLHSGTAGVGLALDSLAASTGD
                     AALHHAAVRCAELSARCLRAGTPGRGPEGRARAGLLHGATGSALLFLRLYERTGDTGLL
                     DLAGVALRQDLARCVRGAGGALQVDEGWRTMPYLGAGSVGIGMVLDDYLAHRADERFER
                     ARDEIVRAAQAMFYAQPGLYRGVAGMVLYLGRTTATGPGTGAAAVRRQIDALTWHAMSY
                     RGHLAFPGEQMMRLSMDLSTGTAGCLLAVASVHGDRPAGLPFLPPPRQEPRPTSRSRTG
                     P"
     misc_feature    complement(12718..12735)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.66"
                     /tool="antismash"
     gene            complement(13348..14412)
                     /locus_tag="B1H29_RS35365"
                     /old_locus_tag="B1H29_35445"
     CDS             complement(13348..14412)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1286: Pentapeptide
                     repeat protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004921193.1"
                     /locus_tag="B1H29_RS35365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_35445"
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="WP_055420858.1"
                     /transl_table=11
                     /translation="MVVLGVVFVVLPAVVVDHDIAGSSVAAQDRLKAVNDVRTTLLQVL
                     AGLVVLFGAYATWRQVRVSQESLRATQEGYVTDRFSRAVDQLGSDKVDVRIGGLHALRR
                     IAEQSARDRDAIVSIQAAYLRTRLPWPPTGPESPADVAINDVAPLETRVADAQVALTGL
                     GAVCRYREESWVNLSVTDLRRADCDGLRLPEVNLDRACMEAAGLYHADLTQASLVSVNL
                     RHADLTTAILRRVRCVLADLRGAKLVETDLRDADFTETDLREANLRKADARGAVFHRAD
                     LRMTDLRGSDLSTADLAEARLTGALASEHTRWPTGFDRSAAGVVHADDPGPEPSPLLQP
                     PGMTWQAPPLRSTP"
     gene            complement(14519..15445)
                     /locus_tag="B1H29_RS35370"
                     /old_locus_tag="B1H29_35450"
     CDS             complement(14519..15445)
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127259.1"
                     /locus_tag="B1H29_RS35370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_35450"
                     /product="NAD-dependent protein deacetylase"
                     /protein_id="WP_055420101.1"
                     /transl_table=11
                     /translation="MRMRPTLSWTPAEDLPPGTTDPEPVADALDTGGVLVLSGAGISTE
                     SGIPDYRGEGGSLSRHVPMTYQDFTADPRARRRYWARSHLGWRTFGRARPNAGHRAVAA
                     FARHGLLTGVITQNVDGLHQAAGSEDVVELHGSLDRVVCLSCGASSPRRVLAQRLEEAN
                     PGFEPVAAGINPDGDADLTDEQVGDFRVVPCTVCGGILKPDVVFFGEAVPPRRVEQCRA
                     LVRESASLLVLGSSLTVMSGLRFVRQAAQDGKPVLIVNRDPTRGDRHALTRVALPLGPT
                     LTTVAERLGIPVDGRPPAPLDHPLRGA"
     misc_feature    complement(15435..15448)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.85"
                     /tool="antismash"
     gene            complement(15620..16510)
                     /locus_tag="B1H29_RS35375"
                     /old_locus_tag="B1H29_35455"
     CDS             complement(15620..16510)
                     /NRPS_PKS="Domain: PKS_KR (56-210). E-value: 1.3e-10.
                     Score: 33.5. Matches aSDomain:
                     nrpspksdomains_B1H29_RS35375_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013005481.1"
                     /locus_tag="B1H29_RS35375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_35455"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_055420100.1"
                     /sec_met_domain="adh_short (E-value: 2.5e-29, bitscore:
                     101.3, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 1.5e-31, bitscore:
                     109.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADDRRDQQDPTDQYPRPDFAAQDQPHPGWTGPMDPPPDHGEESY
                     RGSGRLAGRRTVVTGGDSGIGRAVALAFAREGADVLFTHLAEEEGEARETSRLVEDAGQ
                     KAVAVSCDIREERNCRALIDRAVAEFGGIDVLVNNAAYQMAQPDGIEAIPTEQFDRVVR
                     TNLYGMFWLTKFALPHIPAGGSVINTTSVQAYKPSPHLLDYAMTKGAIVTFTQGLAQMV
                     AERGIRVNAVAPGPVWTPLIPATLPDTAEFGKQSPLGRPAQPAELAPAYVYLASQEAGY
                     VTAEILNATGGTPLP"
     aSDomain        complement(15881..16342)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B1H29_RS35375_PKS_KR.1"
                     /evalue="1.30E-10"
                     /label="B1H29_RS35375_PKS_KR.1"
                     /locus_tag="B1H29_RS35375"
                     /protein_end="210"
                     /protein_start="56"
                     /score="33.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVTGGDSGIGRAVALAFAREGADVLFTHLAEEEGEARETSRLVED
                     AGQKAVAVSCDIREERNCRALIDRAVAEFGGIDVLVNNAAYQMAQPDGIEAIPTEQFDR
                     VVRTNLYGMFWLTKFALPHIPAGGSVINTTSVQAYKPSPHLLDYAMTKGA"
     CDS_motif       complement(16277..16342)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B1H29_RS35375_0001"
                     /evalue="3.60E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="B1H29_RS35375"
                     /protein_end="78"
                     /protein_start="56"
                     /score="13.2"
                     /tool="antismash"
                     /translation="VVTGGDSGIGRAVALAFAREGA"
     gene            16963..17370
                     /locus_tag="B1H29_RS35380"
                     /old_locus_tag="B1H29_35460"
     CDS             16963..17370
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389695.1"
                     /locus_tag="B1H29_RS35380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_35460"
                     /product="DUF2809 domain-containing protein"
                     /protein_id="WP_055420099.1"
                     /transl_table=11
                     /translation="MASAPRTHAGAERAPIRIRLAATVAALAIVGAGTGLRAVASGDVA
                     KYGGDALYCLLMFALVILVAPRVTPPTAAAVALAVSWGVEFLQLTGLPAHLSQQSTAAR
                     LVLGSTFNAPDLFWYAVGAATGWLVVHRMRP"
     gene            complement(17447..20440)
                     /locus_tag="B1H29_RS35385"
                     /old_locus_tag="B1H29_35465"
     CDS             complement(17447..20440)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971264.1"
                     /locus_tag="B1H29_RS35385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_35465"
                     /product="family 16 glycoside hydrolase"
                     /protein_id="WP_055420098.1"
                     /transl_table=11
                     /translation="MSPRSRSRSRGRLAGLVAVSVLFGCFTSAPAGAADTADDLPPQEP
                     GVTLRVFDIGQPMNEICVLKPGQTPNVDKLMPVIDFSTTEDFGVGDHFVSQVIANIEVP
                     EDGAYTFRLTSDDGSRLTIDDRTVIDHDGLHAAEPKEGTVTLTSGHHALRVDHFDRTND
                     QRVTLEWKPPGAAGFSLVPNSALSTDADVVRVTAPGRKQCESGTDTPGDGLPLDGVHPD
                     YTLTDLRPDGFEPQVTGMDWLPDGRMAITTWGGTDKTEGEVYLLDDVTGATGPDKVTVK
                     KVASGLKEPMGIKVLDGALYVSQKHELTELRDTDGDDVTDARRTVATWPYGGNFHEFAF
                     GLLYRDGHFYLNLSVAINYGGATTDPQPAPNRGTTIKVNRKTGKVTYLAGGLRTPNGIG
                     WGPGGDLFVADNQGGWLPASKLVRIKPDRFFNHYTNPAGPFDDQPVTEPVLWLPQNEIA
                     NSPSTPILLKKGPYAGQMLFGDVTYGGLQRAFLEKVKGKDQGAVFRHTQGLEAGVNRIT
                     QGPDGAIYAGGLGAGGNWGQEGKLTHGLQKLTPNGGKAFDIRAMRAKRGGFELEYTQPL
                     SQETADRLAESYQVEQWRYVPTPSYGGPKVDEETLAVTSARLSEDRKKVTLRITGLKPD
                     RVVHVRSPRPFSSAGGETLWSTEAWYTLNAMPGKRPPTTSYEAEEAERSGGAGVNTDHT
                     GYSGSGFVDGYGTQGAATSFTVDVDKKGTYDVALRYANGPNPFTGTKTVSVYVDGTKVK
                     QSSLLSTGGWDDWSTRTESLRLRKGANTITYRVDEGDTGHVNLDMISVHPKGERIVLFD
                     GADRAAWQQTDGRTAQWPLTDGGMEVCCGDLRTKQAFGDFKLHAEFWLPELPPDVTGQD
                     RANSGIYLQDRYEIQILDSFGDTTPADNEAAAIYQQKAADENAARPPGTWQTYDITFRA
                     ARFDDQGAKTEDARVTVVWNGVTVHKDVALSGATAGGAQEAPTAGALRLQDHGNKVRYR
                     DIWIEPLS"
     misc_feature    20591..20611
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.53"
                     /tool="antismash"
     gene            complement(20756..21784)
                     /locus_tag="B1H29_RS35390"
                     /old_locus_tag="B1H29_35470"
     CDS             complement(20756..21784)
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994822.1"
                     /locus_tag="B1H29_RS35390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_35470"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_055420097.1"
                     /transl_table=11
                     /translation="MTRSTPVVGIKDVAREAGVSVGTVSNVLNQPGRVSQRTRHHVEQV
                     IARLGYVRSESARQLRAGRSRVMALLVLDMGNPFFVDLAQGAERTARDAGLAVTLCNSA
                     QSARKEAEYLELFAEQRVRGVLVTPADPSGRSLGEFRRHGIPYVLVDRVADDTEGCSVS
                     VDDVTGGALAIRHLTGAGHSSLAYVSGPSHLRQVQDRRTGALAAVAQAGLPPAALREIP
                     TDRLDVSAGRDAGARLLGLAERPTAVFCANDLLALGILQFMYTAGVKVPDDLAIVGYDD
                     IEFAAAATVPLTSVRQPARTMGAMAADLLLQEAGDRADEHRHEHVVLQPELVVRGSSLS
                     RR"
     gene            complement(21867..22187)
                     /locus_tag="B1H29_RS35395"
                     /old_locus_tag="B1H29_35475"
     CDS             complement(21867..22187)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174871.1"
                     /locus_tag="B1H29_RS35395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_35475"
                     /product="L-rhamnose mutarotase"
                     /protein_id="WP_055420096.1"
                     /transl_table=11
                     /translation="MRRVCFLLKVRSEMVAEYRERHQHVWADMLAALSEAGWHNYSLFL
                     RKDGLLVGYLETDDFEAARAAMDASEVNARWQAEMAEFFEELDGQAPDAAMRPLTEVFH
                     LA"
ORIGIN
        1 cgcccgtcgt cgcagaggca gactccagcc gtgcagaccg atgcgtcccg tcacccgcag
       61 gggtgaggaa gcggtcgctt cccgggtgct gccgtcccgc agcagccgca gcacgggctc
      121 ccaggtcgag aagtcgtgca acgaactcgg ggaaagggtc cggtcaacca tgcgcagacc
      181 gtacgcgggg ccaccgacat cgaagcgcca gggcccgccg cgcgcaccct cactcctccc
      241 gcaggcgcat caccaggtcg cgcggcagcc cgtgggtgtc gtgcaggtaa tggaagtcgt
      301 catccccgag aggaccccgg aaccggagcc gggccagcac cttccggccg cgctccatga
      361 gccggccgaa ccggtcttcc tcctccacca gcagccgacg cacgtggccg gggtcgccct
      421 cctgccggaa gcggtcgagg gtgtgcgaga ccaactcgtc cggcaggtct ccgagactgc
      481 gcgacggatc gtcccgccac agcacggtga gcacccgccg taccaggcgg cgcaacacgt
      541 aaccccgtcc ggtgctggcg gggaggaccc cgtcgccgac gaccacgacg gccgagcgga
      601 ggtggtcgtg gaccaggcgg agtgacggtt cgtccagtgg ccacagggac ggcacgacac
      661 gccgccaggg ctcgaagaca tcgcactcga acaccgacga cttgccctgc agcagtgagg
      721 cgaggcgctc gaggccgagc ccggtgtcga cgttgcgctg ggggagcggc acgaggcggc
      781 cgtcgtcgag tcggcgatgg tgcatcatca cgtggttcca cacctccacc cagcgctcgt
      841 cgcgggtggg tgtcgaccgg ggcggggtgt caccggtcca caggaagatc tccgagtcgg
      901 gcccacacgg gccgaccggc ccgttcgacc accagttgtc ctccaccgtg agctccacgg
      961 gaaccccgtg ctcctgccac cggcgcaggg aagcggtgtc cggtccgacc tggtcaccac
     1021 cgccgtacac ggtggcgtgc agcaggcccg gatcgacccc cagcccctcg gtgagcagcc
     1081 ggtagcccca gtcgagactc cgcgagcccc cgtagtcgcc cagcgaccag gtgcccagca
     1141 tctcgaagac cgtcaggtgc gtactgtcgc cgacctcgtc caggtccgtg gtgcgcagac
     1201 agcgctgtac gttgaccagc cgccggccca gtgggtgtgg gcggccctcc agatacgggg
     1261 tgatcggatg catgccggag gtggtgaaca gcacggtgtc gccgggtggc ggcagcagtg
     1321 tcgaaccgct gatccggcga tgaccgagtt cctcgtagta ctcgacgaac gtgcggacga
     1381 tgcgctccgt gtccatgagg gtgactcctt cgcgtagcgg tgggagaggc accggagagc
     1441 ggaccgcgtg gtcgtcacac tggagcgagg gcgtcggaac gccacgggac caccggcggg
     1501 ccgtttccgg tcgccggtgg gggaggggag aaggtcaggc ggcggcaacc ggcgagctgg
     1561 tcgctcgcgc ggtcgcgaag acgcttcggc cgatgacgtt catgccgagg aagataacgt
     1621 gttccgccca ccccgggcac ttgaatatcg cgccctcgga cggtccagga ccgcccccgc
     1681 ttccgcgatg cgccttcggc ggccgagccc tcgggccggc gctccacggc cggcgcgccg
     1741 ccctccgaca cccgggcgga accccgactt gataggcaag cggatgcttg cctatcctgt
     1801 ggtcgtggcc gacgaccttt tcaaagcctt ggccgaccgg acccgccgca ccatcctcga
     1861 cgagcttgcc gagaagtccg gacagacact gttcgagatc tgttcgcgac tgagcatgaa
     1921 gcaccggctc ggcatctcgc gtcaggcggt ctcccagcac ctggccgtgc tggaggccgc
     1981 cgggctggtc gagacccggc gggagggccg ctacaagttc cacgagctga acacggcccc
     2041 gctgcggcaa atcaccgagc gatggctcgt gcccgacacc atgcccgaca cctccgcacc
     2101 ggaagagagc accccgtgaa gatccatctg accagcgttt tcgtcgagga ccaggccaag
     2161 gctctgcact tctacaccga gattctcggt ttcgtgaaga agcacgacgt gccggtgggg
     2221 gagcgggacc ggtggctgac cgtcgtgtcg cccgacgagc ccgacggcac cgaactcctc
     2281 ctggagcccg ccggccaccc ggccgtcaag gcctaccgcg acgcgctcgt cgaggacggc
     2341 atcccgctgg cccagttcgc cgtcgacgac gtgcgggcgg agtacgagcg cctgcgcggc
     2401 ctgggcgttc acttcaccca ggaacccctg gaaatgggcc ccgtcaccac cgccgtcctc
     2461 gacgacacct gcggcaacct catccagatc gcgacgcagc cgcggtgagt gggctgccgg
     2521 ccgggtctct tccctccgta ccgggtctct gatcaggcgg cccgagtcgc ctcgtgcgcg
     2581 tcgtgcgggc agtcgaacgg gatgccctgg tcgagtacgg cgagtgcgtc tccggaggga
     2641 aggccaaccc agttgatctg gaaaccagcc cctgtttccg gtcggttcga gttcggtatg
     2701 ccctgttgcg aggcgaatga gagacttgga ctgtccgcct tctcaggcgc cgccgcgagg
     2761 accggcggat cggatggccc gggagtggtc gatgttccgc aagcgtcccg cacccgacgg
     2821 tgaagagctg ctggcccggc tggcatcgct caccactcag gcacgggagc tcgctgagct
     2881 gcgccggtcc caggtggagc tggcgatcgc gctccaacgt gacatgctcc ccgcggacct
     2941 gcccgcggta cccgggttcc acctggccgc ctgctattcg cccgcgtacg ccggactcaa
     3001 cgtgggcggt gactggtacg acgccttcgt gctccccgac ggccgtctcg gcctctccgt
     3061 cggagacgtc cagggccacg ccatcgacgc ggcggccttc atggggcaga tccgcgtggg
     3121 cctgcgcgcc ctcgcctccg tgacgagtga gcccggcgac ctgctcgccc gtaccaacga
     3181 ccttctcctc accctggaca aggacctctt cgccacctgc accttcatgc gcttcgaccc
     3241 tgtcaccggc gtcctggaga gcgcgcgggc cggacacgtc ccctgcgtgt gggccacggc
     3301 ggacggcaag gcggaggtct ccgaggacga aggggggcca ccgctgggcg tcctggaggg
     3361 ggccgagtat cccgtgaccc ggtaccggct cacgacgggc ggggtcttcg tgctgctcac
     3421 ggacggcgtg gtggaggggc cttccctgag cgtcgacgaa gggctcgaaa gggtcgtgcg
     3481 gctggcgggc gtcgccgccg tcgccggaat ggacgcgcac tcgctcgcgg ccgccgtgct
     3541 caagaacgcc gagctggtgg gacacgagga cgacgcggcc gtgctcgtcg tcggccacga
     3601 cgggcgtgct gttacgccgt agggcgggac gacgcacggc tcacctcgct gatgcgccgg
     3661 cgccggtgtc tgatggctgc tgtggtgggt atccgggctt ggccgcgacc ggtcgtcttc
     3721 gtcggcgaga cgttgctcgt ctccgtctgc tactacgtgg cgggacgact ggggctctcg
     3781 cagcaactgg tcgcggacgg cgcggtggtc acgcccatct ggccgccgac cggtgtcgcg
     3841 gtggcctgtc tgctgctgtt cggactgcgg tgcgcacccg gtatcgccct cggtgccctg
     3901 ctggtggtcg cgtcgctgac cgctccccgc ctgtccgccg ccgggatcgt gctcggcaac
     3961 accatcgcgc ccgtgtgcgc ccttctgatg ctgcgcgcgg tggggttccg ggtgagcctg
     4021 agccgcttgc gcgacggtgt ggcgctcgtg ttcctcggag cgctgaccgc catgctgatc
     4081 agctcgggcg tgggcgtcgg catgctcgtc ctcacggaca aactcgccgc cgacgacttc
     4141 tggctcgtct ggctggcgtg gtgggtgggt gacgccatgg gcgtcgtgct cgtcactccg
     4201 ctgctgcttc tgctgcaccg ggcccgccgg tcacccccgt ccggccgatg gggcgaggcc
     4261 gtgggtctcg ccctcgtcgt gtgcgtcctg gtgccggtcg tcacgtacag ctcgatcagc
     4321 gtcctgttcc tggtgtatcc gctgctgatc tgggccgcgc tgcgtttcca gctcgccggc
     4381 ggcatgccgt gcgccctgta cgcctccgtg atgaccaccg tcgccgccag ggacgaggcc
     4441 ggttccttcg gcgcgctgac cgacatcgag acgatgatga agcttcaggc gttcaacggg
     4501 accctgggcc tgaccgccct cctgctgtcc gccgtgatca cggaacagat caacaccaga
     4561 cggtcggtgg aacgggcctg ccacgaactg gtcgaggcgt tgcagcatct gaacgccggg
     4621 ggttccggga acacggggcc gcccggccgg ggcgccgggt gagcgaaggc ggtggcagga
     4681 cgggatcagc gctcgcccag gacacgccgg gcggcctctg cctccgccgc cgacggggac
     4741 aactcgtcga gggtgtcgag atcggtgtcc gtcgagagct cccgttccca gtcctccgcc
     4801 agtcgttcct gttcctcgcg aggcctcgcg cttacggcgt cccggtgatc cgggtccaga
     4861 gccgccagga aacgtgcaac cgggtccgtc ggcatggcca tgctcctcat cgtgtcatcg
     4921 tggggaaggg cgccgcttcc ggctcaggat ggccgaccgg gtccgcggcg gccgttcgac
     4981 acggcctccg gccaccctta tggccccgcc cccgaaacgc cgcggcaccg ctgcgccgga
     5041 cggccgcgcg gcggggagac gagcgggaca ttcgggccac attcacttcg cctgttttcg
     5101 gtctgtgaca ctcccgtgac gcaaggcgtc ggctcgccgc accgcgctgt ccgccggccg
     5161 tccggtaccg ccaagcgtga tgtgaacagc ccatgggcgc actctcaacg gagcggcgcc
     5221 gcgggaccgc gcacgggcca cggacgtgtt ccggcccggg ttccgcatcg gcctccccct
     5281 cctgacggcg ctgagaacgg cgcgttgacg tcggtgcggt cccggcgtga tcgagtgccg
     5341 tgcttcctcc gcggcgcccg ggggcagacg gctggggact gactggggga cgagcccggc
     5401 ggcccggggg cggccgggga aagtaggggg ttgtagatgg tccgtgttct tgtggtgcac
     5461 gacgcgacgc tgctgcggtc ggcgctggtg caactgctgc ggtccgccga cggactcgag
     5521 gtgtcgtcca tgccctcccg cggtgaggac ccggacggca acgacttacc cgcggaagtg
     5581 tgcgtggtcg acggcgactg tctggaagga tcgccgagcg acgccggccc agcacccttc
     5641 tgggaccggt gcggggcgcg gctggtcgtc ctcgccgcac cggagcggcc gggtgtgctg
     5701 cgcaaggcgt tcgacgccgg agcgctcggc ttcgtggaca aggacgcctc ctcggagcgg
     5761 ctgatcaccg cggtgcacac ggtggccaag ggggagcggt tcctcgacga gcggctcacc
     5821 gtcgcactgc tgcgggcctc cgagatgccg ctgacggccc gtgagctgag cgtcgtgttc
     5881 caggcgtcgc agggggcctc cgtcgccgag atcgccgcgt gcctgcatct gtcccggggg
     5941 accgtccgca actacctggc cagcgcgatc cggaaggtcg gggcgcgcaa ccgcgtggac
     6001 gcgatccgca tcgtgcagaa ctccggctgg atgtgacggc ggcggggcac gcgtgcgcga
     6061 gagcacggct cgcgggtcat gcccgggtcc ggctccagtg ccccaccagg tcgcggtaga
     6121 ggggggaccg ctccaggagt tcccggtgcg ttccgtgggc cgcccggacg ccgtccagca
     6181 ccagaatccg gtcggcccgg accgcggacg acatgcggtg cgccacgacg agaagcgttc
     6241 cgggccgccg tgcgagcgcc gcctcggcac gtgcctcgga cgccgcgtcg agatggcagg
     6301 tcgcctcgtc gagcaggagc agtcgagccg tggacaggtg agcgcgcgcc aggacgatca
     6361 gttgccgctc gccctgcgag aggtcgtcgg ggcgcagcgg cgcgtcgagc cctcccagac
     6421 gctcgacgag aggggccgct ccgaggtctc gcacggcggc ctcgacgtcc gccgcggagg
     6481 cgtccggccg caggtaggcg aggttgtccc ggaccgaacc cgtgaagacg tacgcctgct
     6541 ggggcaccag gacgcgcagt gcggcgagtt ccgccgcact gcggccggcg accgttcggc
     6601 cgttcacccg aaccactccg ctcctcggcg cgaacatccc ggcgacgagg cgggtgaggg
     6661 tcgacttgcc gatgccgctg ggaccgacga cggccaggtg ctcgccttcc tcgacgcgca
     6721 gatccagcgc gtcgaggacc ggctccgtcc gggcgccgta gcccgcggtc accgcgctca
     6781 gttccacggc ggggacctgc cgcgacggcg gcggagccgg cgggagcgag gagcggccct
     6841 gctgcggcgg cccggcacgc ccgggcaggg gcgtacgcgg cgccgcaccg gtgacggacg
     6901 ggtgcgcctg cggcgcggtg aagcggtcca ggaccacgag cagccgggtg ccggcagcgc
     6961 cgatcgcggt catgagggtg tgcagggcgg gcagcagagc ctgggcgagg taggtgaacg
     7021 ctccgagcag ggcgccggtc gtgacccccc tgtcgcgcag ccagggcacg gcgaccagca
     7081 ggagcagtac ggggagctgt cccgagacgc cgagggcgag ggtgcgcacc gcggcccagc
     7141 gggcgaggac ccgggacgcg gcggcggcgt ccgccacgag tcgtgctccg cttcgtgccg
     7201 cctccggctg ggtgccgcag gcggtgaggt cacgcagcgc tccacgggtc cgggtgacgt
     7261 gatcgcccag tgcctcgtcc gcggtgagag cccgccgctg cgccgccgcc atgggccgca
     7321 gcgtcgccag gaacagggcc aggccgccgg cgagtggcgg caggacgacg accaggagcg
     7381 ccgggtccag cgagaacagc cccacgagcg ctccggccgc ggtgaacacg aacgagcgga
     7441 cggtgaggac gagcccggcg aagctgtccc gcacgatctc gacctggttc gtgagccgtg
     7501 agacggcggc gcggtccccg ccgccggggc gggacagggc gcgggccatg gactggtcga
     7561 ccgcccgccg cacgagcccg tcgcgcagcg gttccgtcag cccggccagt tgcgcgaaga
     7621 cgcccctgac cacgggcgcg ccgagcacca cggcgcaggc ggccaccccg agccagccga
     7681 gacccgtgag ggtgtcaccg gcgaggaacc cccggtcgac ggcctgggcg acgccgtaac
     7741 cgaccacgaa cgtctgtgcc gactcggcca gtgaccatcc cgcgagccgc acgaggaccg
     7801 tcttgcgtcc ggccaggaaa cggcgggcgg acgggccgac ccggcgcagg ggcccgggcc
     7861 ccgagccacg ccggcgcttc cccgcacgcc gttcgtcggt ggatgtcacg gtcgtgtccc
     7921 ttcgcgcaga acggcggtcc gtccgccacg gcgcccgtca gggcggtcct cggtgggcga
     7981 cggcccgaca ccgttctccc tcgtaccgaa caccgcccgg taggccgcct cctcccacag
     8041 gcgccgatgg gtgtccaccg cccgcacccg gccgtcgtcc agccagatca cgagatcggc
     8101 ccgggccgcg accgacgggc ggtgcgccac gaccagtcgt gtggcggctt ggggcgagcg
     8161 gcgctgagcc tgttccaccg cgtgctccgt ggccgtgtcg aggctggagg tcgcgtcgtc
     8221 catcaccagc agcctgcccg cgtgggcgaa ggcccgcgcc aggcccagcc gctggtactc
     8281 gccgccggaa aggggcgtgt cggcgagcgg ggtgtcgtag gcccgcggaa gccggcgtac
     8341 gaaggcttcg gcgtccgcga ggcgaatcgc ctcctgaacc tggtggggtg acacggtgcg
     8401 cggtccggcc gccacggcct cggcgacggt gcggtcgccc agtaccggac gcgcgaaggc
     8461 gaaaccgacc tcggcacgca ggcaggagcg ggtcagaaga tcgagaggcg tgccgtccag
     8521 caggacctgg ccctggtcgg gatcgatcag ccggccggcg acggcggcca ggacggactt
     8581 gccggcgccg ctgcgcccca cgaccgcggc ggtcaggccg cccggcaccg ccacgtggtc
     8641 cgcccgcagg acttccgttc cctcccgctg gacccgtacc ccgcgcagtt cgagggcacc
     8701 cgggcctccc ggcggcaggg accgggttcc gtaggacagg gcgggcaggc gttccagcgt
     8761 cgtggtgcgc tcgcgcgccg cgcggccccg caccagcgcg ccgaccagag tggcggcccc
     8821 gccgaacccc gcggccaact gcgcgtaccg gcacaccgcc agcagttcgc cgacgctcag
     8881 ggcacccgag ccgagccgca ggccacccac cgcggtggcg gccaccgtca gcagcgggac
     8941 gaggacaccg ccggtggcca acgcctttcc gtgcagtttc cacatgcgtg cgcccagcgt
     9001 gccgagttcg gccagtgggc ggagcacgcg ctcgcgttcg cgcgcggcgg tcccggcggc
     9061 ggcgatggtt tccgcgccct ccatcgtctc cagcagccgg gaggcgatgt ccgactggac
     9121 ccgctgatag gccccgaccg aaacccccgt gtctcgcgcg aacgcccgca acaccagtac
     9181 cagggccggt agtccggcca gcacacatac ggcgacccac acgtcgacga cggccagtgc
     9241 gaccagcgcg ccggacggag tcaggagcga ggccgcgagt gccgccctgg cagccggcgc
     9301 ggcgcccgcg tcggaggcgt tgagcgtcag ccgggtcgcg acgtctccgg gagaataggg
     9361 gcgggccagt tccggcacgg cgtgcagcag accgctgaga gcacgcgagc ggatcgaggc
     9421 cgtccagtcg gcggtgcacc ggccggtgag cagcgcggtg agaccgtcga ggagaacctc
     9481 gccgacgagc agtgcggcgc tcgccgcgag ccagcggccg gcggcgccgt cgtgcagcag
     9541 caggtccaga gtgcggccca ggacgagggg ctggacgacg gcgaccgctg ccgccgccac
     9601 cgagcacacc aggaccagca gttcgggcac ccgtcctggg ccggtgccgg gcgagccgtg
     9661 cgtcggacgc gtcggttgcc gtcggtccgg ggtggttccc accggctccc cctcctcgtg
     9721 gtcgtgccgt ccgcgggcgg cgacgaggcg cggtaccggc gcccgggcgg tgcggccggg
     9781 cgccggtacc caagcgtgcg gcccgccgcg atactcgcgg cgggccggct gcgacgtcag
     9841 ttacacgtcg tgacgctgag gctgctgtcg ccgcagagca gcaggctcgc gcggctgccg
     9901 gtctccacgt cgcccatggc ctcttccttg ggggtctcca tcgactgcat ctcgaacagg
     9961 ttcatgtgct cttcccttcg tacggcaacg ggtgttctct tcacggcccc gtacgggacc
    10021 ggctcgtggg ccgcggctcc tgccgcggcg gtgggaggaa cggcaggccg gcgggccggt
    10081 cgccgtggac ggacgcgacg gccagcaggc atccggccgt tccggtggag aggtccatgg
    10141 acaggcgcat catctgctcg ccagggaagg cgaggtggcc gcggtaggac atggcgtgcc
    10201 aggtcagcgc gtcgatctgg cgccggacgg ccgctgcccc cgtgcccggc ccggtggccg
    10261 tcgtacggcc gaggtacagc accatgccgg ccacaccgcg gtagagcccc ggctgggcgt
    10321 agaacatggc ctgggccgcg cgcacgatct cgtcccgggc ccgctcgaac cgctcgtcgg
    10381 cgcggtgtgc caggtagtcg tcgagcacca tgccgatgcc cacgctgccg gcaccgaggt
    10441 acggcatggt gcgccagccc tcgtccacct ggagggcacc ccccgcgcca cggacgcagc
    10501 gcgcgaggtc ctggcgcagt gcgacgcccg cgaggtccag cagaccggtg tcaccggtgc
    10561 gttcgtacag gcgcaggaac aacagggcgc tgcccgtcgc gccgtgcagc agaccggccc
    10621 gggcccggcc ttcgggcccc cggcccggag tgccggcccg caggcaccgg gcgctcagct
    10681 cggcacaccg cacggccgcg tggtgcaggg cggcgtcgcc ggtggaggcg gccagggagt
    10741 ccagcgccag gcccactccg gccgtcccgc tgtggaggtc cgcggcgagg tcgtcgaagg
    10801 gatgctcgag gagcaaccgg gtgaggtcga gcgcccgggc ccgatgaccg aggtggtcca
    10861 gggtccaggc gactcccgcg atcccgtcgt ggaagccgag cggcatcccc gagggcggtt
    10921 ccttggtccg gtcgagcagc cactgctcct cgccctcgtc gcgctccgcc ccgctctcgg
    10981 ccagggcgta cagcacaccg gccgctccgt atccgaacga gagccctccg cccgcggtgg
    11041 cgaactgagc gacgtcgccg gggaagaggc ggtcctcgcg cgaaggagtg gccgccgcgc
    11101 ggacggccgc cgtcatcgag tcccggctgc ggggccagtc acccggtgcc acggggacga
    11161 agtgctcggt cgccggtcgt gccgccggtc gccgaccgga agcgtcggcg atctcgtcga
    11221 gcgccgcgtc caggaaggcg cggtccacgg ggaactgccg tgccaccacg tcggcgaggt
    11281 gctccgcctt gcgccggtcc agggcaagca gactggtcag cggcaggaac agggccaggc
    11341 gcaggcaggc cagcgcgtaa cggtccacag cggtgccccg tcggccgggc ggtgccacga
    11401 acccgggatg ggcgaccgtc tgccggcccg gctcgtccac gcggtgggcg gcctcgaagt
    11461 ccagcagggc cacccgcccg tcgtcgcgga tcatgatgtt gaagagatgc aggtcgttga
    11521 agaccacgcc gcgtgcgtgc acctcctcga cggctcgctc gacccgggcg tggacatcga
    11581 gcgcccactc ggtgtacccg gtcagccgcc ggtcgtcggg atcggcctcg atgagcggat
    11641 gccgacgggc gaagaaggtg ttgagaggct tgccgtcgag atactccagc accaggaagt
    11701 ggtggtcccc gacggtgaag ctgtccagca cctcgggcgt acaggacagg cccgacaact
    11761 gctccagggc ccggcgttcg cggtgcagcc gggtcaccgc gtcggcaccg tcggccgcca
    11821 gaccggcgta cgggcgggcc tccttgagga ccacgaccgc accggtacgg gtgtcccgcg
    11881 cccggtagac accgccgccg ttggagaagt gcagcgccga ctcgacggtg tacgggatgt
    11941 cggtcagcgt caccgtcgcc cgcgcctcga cgtggggccg caggaaggcg ggcacgtcca
    12001 cccagtcggg gacgcggaac accggaccgc ggaagtcggg gacgagtact ccctcggggt
    12061 ccgcgacggc cggccgcagc tccccgttct cgtcgtagca gttgcggcgg gtgaagctgc
    12121 cgtagcgcac gtgcaccggg ccggcaccga tcctgaggtc gctcaggatg tgcgggccgg
    12181 gctcgccgtc cagcagcgcg gccaactcgc ccacgaggtg ttcgaactgc tcctcgtccg
    12241 ccgggtacac ggtgatgaac ttgccgctgc cggcccggtc cgcgtacttg gcgttgcgct
    12301 ggtgcagcag atagcggctc ggcacgaact tgaacgcgac gccgcgctcg acgcagtggt
    12361 gccgtacgcg ctccaggacg gattcggcgt tctccaggca ggcggagacg tggatcttcc
    12421 aaccctgcgg cggcagtacg gcgtccagcg ggcgcagagc gagccagtcg ccgctctccc
    12481 cgcgctgcca tcccgcaggt acgggcaggc cggccgcggc gtaccgggtg tcggccgctc
    12541 gggtgccggg gccggtgcga tgcggcgcgt cgtagaagtg cgggtccgcg tcgcagtaca
    12601 cggcgtagcc cttgttcacg ccttctccct ccatccggtc cacccgtcgt tgcggacacg
    12661 acgctgtcat gcgccgcagg gccccggaca gtcaccgctg tcacctctcc gacgtgcgga
    12721 acgcacaggt aacttcgccc ggcgggcgtg gcgcgcggtc cgggtcagca cagcctcacc
    12781 acggcacggg tgcggtgccg ggcgcggcag cgcagggtgg gtccggtgac tccgcacaca
    12841 cgggcggttc ggtgccgacg ggctgtcacc ggcttcgtcc ggggcggcgg cgggccgggc
    12901 ttcgagcggg tcgtcgggcc cgtggcaggc ttcctcgccc accgggccgg ggacggtccc
    12961 ggccgtccag cccccggcgc tcccaggtgg tcaccggcgc ggagaaggtt cccgagccgc
    13021 cccggtgccg aagtcgtccg cgcgtggtcg ggccttctgg atggtgagcg gcgagctcac
    13081 ccaggacacg ggccgccggt gccgggtcga ccagccactt cggccgtcga agcgctgtgc
    13141 ggcagcggcc gggccacgcg ggcacgccgg accgacggac ctcgacggga gaaccggggt
    13201 gcgctgccgc ctcctcgacc cgccacccgg tccggggagc accgcgtggc gcgcaccgcg
    13261 cgcgaactca acgtcggctc ccgtacgggc atcgccgcgg ccggggacgg gaacggcctt
    13321 tcgggacggt gatggccgcg tgcccggtca cggtgtcgac cgcagcggcg gcgcctgcca
    13381 cgtcatgccc ggcggctgaa gaaggggcga gggctcgggg ccggggtcgt cggcgtggac
    13441 gaccccggcg gccgagcggt cgaaacctgt gggccaccgc gtgtgttcgc tggccagggc
    13501 accggtcagc cgcgcttcgg cgaggtcggc cgtgctcagg tcgcttcccc gcaggtcggt
    13561 catgcggagg tcggcgcggt ggaagacggc gccacgcgcg tcggccttgc gcaggttggc
    13621 ctcgcgcagg tcggtctcgg tgaagtcggc gtcacgcaga tcggtttcga ccagtttcgc
    13681 accccgcagg tccgccagaa cgcaacgaac ccgccgcaga atcgccgtcg tgagatcggc
    13741 gtgccgcaga ttgaccgaga ccagggaggc ctgggtcaga tcggcgtggt acaggcccgc
    13801 cgcctccatg caggcgcggt cgaggttgac ctcgggcaac cgcagcccgt cgcagtcggc
    13861 ccggcgtagg tcggtgacgc tgaggttgac ccaggactcc tcccggtacc ggcacacggc
    13921 gccgagcccg gtcagcgcca cctgagcgtc ggcgacgcgg gtctccagcg gtgccacgtc
    13981 gttgatggcc acgtccgccg gcgattcggg cccggtgggc ggccagggca ggcgagtacg
    14041 caggtacgcg gcctggatcg agacgatggc gtcccggtcg cgcgcggact gctccgcgat
    14101 ccgccgcagg gcgtgcaacc cgccgatgcg gacgtccacc ttgtcgctgc cgagctggtc
    14161 gaccgcccgg ctgaaccgat ccgtgacgta gccctcctgg gtggcgcgca gactttcctg
    14221 gctcacccgc acctgccgcc acgtggcgta cgcgccgaag agtacgacga gaccggcgag
    14281 tacctgcaga agcgtcgtgc ggacatcgtt caccgccttc agccggtcct gcgcggccac
    14341 gctcgatccg gcgatatcgt gatcgaccac cacagcgggc aggacgacga acaccacgcc
    14401 cagaacgacc agccccaccg tcccgaccac cacggccgcg actcgccgcc gcctgaccag
    14461 cctgcggcgc catggccgcc gaccgcgatc cactcccccc gactccatgg ccgggagcct
    14521 aagcacctcg caagggatga tcaagaggcg ccggcggtcg gccgtcgacc gggatgccca
    14581 gccgttcggc cacggtggtg agagtcggtc ccagcgggag cgcgacccgg gtgagggcgt
    14641 gccggtcgcc gcgcgtcggg tcccggttga cgatcagcac cggcttcccg tcctgggccg
    14701 cctgacggac gaaccggagg ccggacatca ccgtcaggga ggaccccagt accagcagcg
    14761 aggccgactc gcggaccagt gcgcggcatt gctcgacccg tcgcggagga acggcctcgc
    14821 cgaagaacac cacgtccggt ttgaggatgc cgccgcagac ggtgcagggc accacacgga
    14881 agtctccgac ctgttcgtcg gtgaggtcgg cgtcaccgtc cgggttgatt ccggcggcga
    14941 ccggctcgaa gcccggattg gcctcctcga gccgctgggc gagtacccgg cgcggactgg
    15001 aggcaccgca ggacaggcag acgacccggt ccaggcttcc gtggagttcc acgacgtcct
    15061 cgctgccggc ggcctggtgc agaccgtcga cgttctgggt gatcactccc gtgagcaggc
    15121 cgtgccgtgc gaacgcggcg acggcccggt gcccggcgtt ggggcgggcg cggccgaagg
    15181 tgcgccagcc gaggtggctg cgcgcccagt accggcggcg agcccgggga tcggcggtga
    15241 agtcctggta ggtcatcggg acgtgccggc tcaggctccc gccctcgccc cggtagtcgg
    15301 ggatgcccga ctccgtggag atccccgccc cgctgagcac cagcacgccg ccggtgtcca
    15361 gcgcgtcggc gaccggctcc gggtcggtgg tgcccggcgg caggtcctcg gcaggggtcc
    15421 agctcagagt ggggcgcatg cgcatgccgc cagggtacgg acatgcgcgt gccgccgcgg
    15481 tacggaacag gctgctcgcg gcccggaccg gcccggaccg cgaccgcctc gtggcggacg
    15541 gcggacggcg gacggcagcc ggacggaggc cgaccacggt ggcgccgtcg tccccctgcc
    15601 gggcccccga ccgtcggggt cacggcaggg gcgtgccacc ggtcgcgttc aggatttccg
    15661 ccgtgacgta gccggcctcc tgcgaggcga gatagacgta cgccggcgcc agctcggccg
    15721 gctgcgcggg gcggcccagt gggctctgct tgccgaactc ggccgtgtcc ggcagcgtcg
    15781 cagggatcag cggagtccac accggccccg gggccacggc gttcacccgg atgccgcgct
    15841 ccgcgaccat ctgggcgagc ccctgggtga aggtcacgat cgcgcccttg gtcatcgcgt
    15901 agtccagcag gtgcgggctg ggcttgtacg cctggaccga ggtggtgttg atgacactgc
    15961 cacccgcggg gatgtgcggc agggcgaact tcgtcagcca gaacatgccg tagaggttcg
    16021 tccgcacgac ccggtcgaac tgctcggtcg ggatcgcctc gatgccgtcc ggctgagcca
    16081 tctgataggc cgcgttgttc accaggacgt cgatgccgcc gaactccgcc acggcccggt
    16141 cgatcagcgc ccggcagttc cgctcctcac ggatgtcgca ggagacggcg acggccttct
    16201 gcccggcgtc ctccaccagg cgggaggttt cccgtgcctc gccctcttcc tccgcgaggt
    16261 gggtgaacag cacatcggcg ccctcgcgtg cgaaggccag ggccaccgct cggccgatgc
    16321 cggagtcacc gcccgtgacg acggtcctgc ggcccgccag acggcccgac ccgcggtagg
    16381 actcctctcc gtggtcgggc ggcggatcca tcggcccggt ccagccgggg tgcggctggt
    16441 cctgggcggc gaagtcgggg cggggatact gatcggtcgg atcctgctgg tcacgccggt
    16501 cgtccgccat gtcggcctcc tgtgtctcgc ggggcgaagt cagcgaccgt gttccctggc
    16561 cggcccgtcc gaaagccact ccacccgagc gtgacgctcc ggcctcccgg cggtgccacc
    16621 aacatcttca tcgacgtcgc cgaatcccgg ctcccgggcg tccccgcctg ctgagcccgc
    16681 ggacggctcc ggcgggcggc cggcggcgtg ccggctcgcc gcggacggcg cccggcgctg
    16741 tgccttcgcc ggcaccctcg ttgtcatcgc gtgccccgcc cgatcgggcc ggcgcgcggc
    16801 ttcgcctctc ccacaccgtg cgtcatgccg ccctcggggt ggtcgagcac gcggtgcggg
    16861 acgacggcgc ccgaggtctg cgcgggtacg ccccggcgcg tcgcgagcgg cgccggcggc
    16921 cccggccacc ccgccgcccg ccgtgcccag cacaatgacc gcatggcctc cgctcccaga
    16981 acccacgccg gcgccgagcg cgccccgata cggattcgtc tcgcggcgac ggtggccgcc
    17041 ttggcgatcg tcggtgccgg aacggggctc agggccgtgg cgtcgggaga cgtggccaag
    17101 tacggcggag acgccctcta ctgccttctg atgttcgccc tggtcatcct ggtggcgccg
    17161 cgggtgacgc cgccgacagc cgccgcggtc gccctggccg tcagttgggg tgtcgagttc
    17221 ttgcagctca ctggcctgcc ggcacacctc tcacagcaga gcacggctgc ccgtctggtc
    17281 ctcggttcga cattcaacgc gccggacctc ttctggtacg cggtcggcgc ggcgaccggc
    17341 tggctcgtcg tacaccggat gcgcccgtga ccggcaggtc gacacagacc acggacgacg
    17401 gtggccggcc cgggggtgtc cgggccggcc accgcctcgt gagccgctac gacagcggct
    17461 cgatccagat gtcgcggtac cgcaccttgt tgccgtggtc ctgcagccgg agcgcaccgg
    17521 ccgtcggggc ctcctgggcg cccccggcgg tcgcgccgct cagcgccacg tccttgtgca
    17581 cggtcacgcc gttccacacc acggtgacac gcgcgtcctc cgtcttggcg ccctggtcgt
    17641 cgaagcgcgc cgcacggaag gtgatgtcgt acgtctgcca cgtgcccggc gggcgggccg
    17701 cgttctcgtc ggcggccttc tgctggtaga tcgcggccgc ctcgttgtcc gcgggcgtgg
    17761 tgtcaccgaa cgagtccagg atctggatct cgtagcggtc ctgaaggtag atgccgctgt
    17821 tggcacggtc ctggcccgtg acgtccgggg gcagctcggg cagccagaac tcggcgtgga
    17881 gcttgaagtc accgaacgcc tgcttcgtgc gcaggtcgcc gcagcagacc tccatcccgc
    17941 cgtccgtcag cggccactgc gcggtgcggc cgtccgtctg ctgccaggcc gcgcggtcgg
    18001 cgccgtcgaa caggacgatg cgctcgccct tgggatgcac gctgatcatg tcgaggttga
    18061 cgtgaccggt gtcgccctcg tccacccggt aggtgatggt gttggcgccc ttgcgcagcc
    18121 tcagcgactc ggtccgcgtg gaccagtcgt cccagccgcc cgtactgagc aggctcgact
    18181 gcttcacctt cgtgccgtcc acgtacacgc tcaccgtctt ggtgccggtg aaggggttcg
    18241 gcccgttcgc gtaccgcagg gccacgtcgt aggtgccctt cttgtccacg tcgacggtga
    18301 acgaggtggc cgcgccctgg gtgccgtagc cgtccacgaa gccgctgccg gagtagccgg
    18361 tgtggtcggt gttgacgccg gcgccgccgg atcgctcggc ctcctccgcc tcgtacgacg
    18421 tcgtcggggg acgcttgccc ggcatggcgt tgagcgtgta ccaggcctcg gtgctccaca
    18481 gcgtctcgcc cccggccgag ctgaacggac gcggtgagcg gacgtgcacc acccggtcgg
    18541 gcttgagtcc cgtgatccgc agcgtgacct tcttccggtc ctcggacagc cgtgcggagg
    18601 tcacggcgag ggtctcctcg tcgaccttgg gtccgccgta ggacggtgtc ggcacgtagc
    18661 gccactgctc gacctggtag ctctcggcga gcctgtccgc agtctcctgg gacagcggct
    18721 gggtgtactc cagctcgaaa ccgccccgct tggcgcgcat ggcccggatg tcgaacgcct
    18781 tgccgccgtt cggggtcagc ttctgcagac cgtgggtcag tttgccctcc tggccccagt
    18841 tgcccccggc gcccaggccg cccgcgtaga tcgcgccgtc cgggccctgg gtgatgcggt
    18901 tgacgcccgc ctcgagaccc tgggtgtgcc ggaagaccgc accctggtcc ttgcccttca
    18961 ccttctccag gaaggcacgc tgcagtccgc cgtaggtcac gtcaccgaac agcatctggc
    19021 cggcgtacgg gcccttcttc aacaggatcg gtgtgctggg ggagttggcg atctcgttct
    19081 gcggcagcca cagcaccggt tcggtcaccg gctggtcgtc gaacgggccg gccgggttgg
    19141 tgtagtggtt gaagaagcgg tcgggcttga tgcggaccag cttcgacgcg gggagccagc
    19201 cgccctggtt gtcggcgacg aagaggtcgc cgccggggcc ccagccgatg ccgttcgggg
    19261 tgcgcagtcc gccggcgagg taggtcacct tgccggtctt gcggttcacc ttgatcgtgg
    19321 tgccgcggtt cggtgccggc tgcgggtccg tcgtcgcgcc cccgtagttg atcgcgacgg
    19381 agaggttcag gtagaagtga ccgtcgcggt agagcaggcc gaaggcgaac tcgtggaagt
    19441 ttccgccgta cggccaggtc gccacggtac gccgcgcgtc ggtgacgtcg tcgccgtcgg
    19501 tgtcgcgcag ctcggtgagt tcgtgcttct gcgacacgta cagggccccg tcgagcacct
    19561 tgatgcccat gggttccttg aggccgctcg ccaccttctt caccgtcacc ttgtcggggc
    19621 cggtcgcgcc ggtgacgtcg tcgaggaggt acacctcgcc ctcggtcttg tcggtgccgc
    19681 cccacgtggt gatggccatt cggccgtccg ggagccagtc catgccggtg acctggggct
    19741 cgaaaccgtc gggccgcagg tccgtcagtg tgtagtcggg gtgcacgccg tcgagcggca
    19801 gtccgtcgcc cggcgtgtcg gtgccgctct cgcactgctt gcggccgggg gccgtgaccc
    19861 gtacgacgtc ggcgtcggtg ctcagggcgg agttcggcac gagggagaag ccggcggcgc
    19921 cgggcggctt ccactccagc gtcacccgct ggtcgttcgt ccggtcgaag tggtccacgc
    19981 gcagggcgtg gtgaccggac gtcagggtga ccgtgccctc cttgggctcc gccgcgtgga
    20041 ggccgtcgtg atcgatgacc gtccggtcgt cgatggtcag gcgtgagccg tcgtcgctgg
    20101 tcagccggaa ggtgtaggcc ccgtcttcgg gaacctcgat gttcgcgatg acctgcgaga
    20161 cgaagtggtc accgacgccg aagtcctcgg tcgtggagaa gtcgatgacg ggcatcagtt
    20221 tgtcgacgtt cggggtctgt ccgggcttga gcacgcagat ctcgttcatc ggctgtccga
    20281 tgtcgaagac gcgcagtgtg acgcccggtt cctgcggtgg caggtcgtcg gcggtgtcgg
    20341 cggcgccggc gggcgccgag gtgaagcagc cgaacaggac cgagacggcg accagaccgg
    20401 ccagccgtcc gcgggatctg gagcgggacc gtggactcat gcatcctccc cggggcgacc
    20461 ccgtggcggg gccgcccatg acggtggtac gggacgacga ggtggtgcgg ccggcgtcct
    20521 gccgaccgaa gtgacgcgtg gtgtgcgtga gatgcctgga ttccaccggg cgtcggacac
    20581 cataggagcc ttttgctcgc tgcgtctata agtttgtcat cagtgagtac aaactctgtt
    20641 cgtcgacggg tgaagaacgc ggatctccgg ccgggtttcc ccttcggtgg acatagtcgg
    20701 ccgcgactcg ggccgagagc gaccggcgcc cccgcggggt gcggcggggc cggcctcagc
    20761 gcctggacag gctcgagccg cggacgacca gctcgggctg gagcaccacg tgctcgtgac
    20821 ggtgctcgtc cgcccggtca ccggcttcct ggagaagcag atcggctgcc atggcgccca
    20881 tcgtgcgtgc gggctggcgg acggaggtca ggggcacggt cgccgcggcg gcgaactcga
    20941 tgtcgtcgta cccgacgatc gccaggtcgt cggggacctt gacgccggcc gtgtacatga
    21001 actggagtat cccgagggcc agcaggtcgt tggcgcagaa gacggcggtg ggccgctccg
    21061 ccaggcccag cagtctggct ccggcgtcac gtccggcgga cacgtccagg cggtcggtgg
    21121 ggatctcccg cagcgccgcg gggggcaggc cggcctgggc gacggcggcc agcgccccgg
    21181 tcctgcggtc ctgcacctgc ctgaggtggg acggtccgct gacgtaggcg agggagctgt
    21241 gcccggcacc ggtgaggtgg cggatcgcca gggcaccgcc ggtgacgtcg tcgaccgaga
    21301 cggagcagcc ctccgtgtcg tccgccaccc ggtccacgag aacgtacggg atgccgtgcc
    21361 gccggaactc gcccagactg cgcccactcg gatcggcggg cgtgaccagc accccgcgga
    21421 cccgctgttc ggcgaagagt tcgaggtact ccgcctcctt ccgcgcgctc tgcgcgctgt
    21481 tgcacagggt gacggcgagt cccgcgtccc gggccgtgcg ctcggctccc tgggccaggt
    21541 cgacgaagaa cggattgccc atgtcgagga cgagcagtgc catcacacgg ctgcggcccg
    21601 cccgtagttg ccgggcggac tcgctgcgca cgtaacccag gcgtgcgatc acctgctcca
    21661 cgtgatgtcg tgtccgctgc gagacccggc cgggctggtt gagcacattg gagacggtgc
    21721 ccacggagac gccggcctcc cgtgccacgt ccttgatgcc gacgaccggc gtggagcgcg
    21781 tcatgtgtgt ctgtctcccg ctgttctgcc cccgcccatc gagccggtcc gggaagcgtt
    21841 catcgtacga agccgggacc ggccgttcac gccaggtgga agacctcggt gagcgggcgc
    21901 atggcggcgt cgggcgcttg gccgtccagt tcctcgaaga actccgccat ctcggcctgc
    21961 caacgcgcgt tcacctcgct cgcgtccatg gcggcccggg ccgcctcgaa gtcgtcggtt
    22021 tcgagatagc cgacgagcag accgtccttg cgcaggaaga gggagtagtt gtgccagccg
    22081 gcctcggaga gcgcggcgag catgtcggcc cacacgtgct gatggcgctc gcggtattcg
    22141 gcgaccatct cggagcggac cttgagaaga aagcagacac gtcgcatcgg atcaccctgt
    22201 tgccgaaggt ggggccccgg cgatcgccgg ggccccacga ctgtcgtgcg gatcagaagt
    22261 cgtactcgtc gatgttggcc ttgtcgaata cggtcggctc acccggggag acgacaccgt
    22321 ccgctccgat ggtcacggtg ccgaggtcgc cggcggtgaa ggtctcgccc ttccggccgg
    22381 tgatctgacc ggattcgagg gcgaccgcgg cgtgggcggc gagcgcgccg agcttggccg
    22441 gctcccacag ctcgaactcc tcgacggtgc cgttcttgac gtaggcgcgc atgtcgttcg
    22501 gggtgccgag gcccgtgagc ttgaccttgc ccttgtactt ggagccggac aggtactggg
    22561 cggcggcctt gatgccgacg gtggtggggg agatgatgcc cttcaggttc gggtactcc
//
