LOCUS       NZ_CP019724            22571 bp    DNA     linear   CON 01-JUN-2024
DEFINITION  Streptomyces pactum strain ACT12 chromosome, complete genome.
ACCESSION   NZ_CP019724
VERSION     NZ_CP019724.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces pactum
  ORGANISM  Streptomyces pactum
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8550793)
  AUTHORS   Xue,Q., Yan,X., Jia,L. and Yan,H.
  TITLE     Streptomyces pactum ACT12 Genome sequencing and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8550793)
  AUTHORS   Xue,Q., Yan,X., Jia,L. and Yan,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-FEB-2017) College of Life Sciences, Northwest A&F
            Unversity, No.22 Xinong Road, YangLing, Shaanxi 712100, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: AUG-2016
            Assembly Method                   :: SMRT v. 2.3.0
            Assembly Name :: version 2.3.0 of the PacBio Single Molecule Real
            Time
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002005225.1-RS_2024_06_01
            Annotation Date                   :: 06/01/2024 05:58:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,315
            CDSs (total)                      :: 7,221
            Genes (coding)                    :: 6,992
            CDSs (with protein)               :: 6,992
            Genes (RNA)                       :: 94
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 229
            CDSs (without protein)            :: 229
            Pseudo Genes (ambiguous residues) :: 0 of 229
            Pseudo Genes (frameshifted)       :: 84 of 229
            Pseudo Genes (incomplete)         :: 195 of 229
            Pseudo Genes (internal stop)      :: 15 of 229
            Pseudo Genes (multiple problems)  :: 62 of 229
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:20:20
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6499786
            Orig. end                         :: 6522357
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP019724.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Northwest A&F Unversity.
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22571
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="28"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22571
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22571
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12571](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12571
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            1555..3024
                     /locus_tag="B1H29_RS27870"
                     /old_locus_tag="B1H29_27900"
     CDS             1555..3024
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976913.1"
                     /locus_tag="B1H29_RS27870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_27900"
                     /product="alkaline phosphatase PhoX"
                     /protein_id="WP_055416316.1"
                     /transl_table=11
                     /translation="MSLTRRDFASRSALTGAGVVLAGSVGALATAPNALASTDTESAGE
                     EHDRGRGRGHDHGGVGYGPLVPDPDGILALPAGFRYEIITYCGRTRLESGEYTPSNHDG
                     TAAFDGPRGTTLLVNNHELGGHRDDWAHPVPLAEGLVYDPAAAGGCTVVEVRRGGHVAE
                     WVGIAGTAQNCAGGSTPWGTWLTCEETEDKAGEEGMTKDHGYVFEVDPEDRRANRDPEP
                     IKALGRYAHEAVVVDPKRGHLYLTEDASGPNGLFYRWAPPEGFRHGRGRLRTLADDAGV
                     LQAFKCFDSGGKFVDDLSRATRTGTVYGVDWVDVPDRDAENTSVRRQFTDGQVTRARKL
                     EGMWWADGGAYIVSSFARDESPGRPHDGQVWFYDPGRRTLTLKVLLGVNPDPSADGAFD
                     GPDNITVSPYGGLVIAEDGDGVQHLFGATDSGRTYPIARNDLNVGSEDDPEYSEFAGVT
                     FSPDGKTLYANIQDPGIMVAITGPWKRQKRR"
     tRNA            3017..3142
                     /anticodon=(pos:6502889..6502891,aa:Met,seq:cat)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="B1H29_RS38240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Met"
     gene            3017..3142
                     /locus_tag="B1H29_RS38240"
     gene            3496..5079
                     /locus_tag="B1H29_RS27875"
                     /old_locus_tag="B1H29_27905"
     CDS             3496..5079
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019329267.1"
                     /locus_tag="B1H29_RS27875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_27905"
                     /product="TROVE domain-containing protein"
                     /protein_id="WP_055416315.1"
                     /transl_table=11
                     /translation="MARFNTKAAKAQPTSRVTSTGRVLRTYEGGRGRERDPRSELFLLA
                     VANLVSQQTFYESGAARDDRFAALVRELAVSDPSWTAGLLGWLRGEGNLRTASVVGAAE
                     YVKARLDAGATDGPANRQVVASVLQRPDEPGELLAYWTATYGRAVPKPVKRGIADAVRR
                     LYHGKSLLKYDTASKGYRFGDILNLVHAAPDPDKPWQGELFQYALDRRHNPDTAVPPAS
                     NRVLTAHRELMALPVGRRRAVVTAPDGAERLAAAGITWEMLAGWLQGPMDKAAWEAVIP
                     SMGAMALVRNLRNFDEAGVSDEVAARVAARISDPDQVARSRQFPFRYLAAYRHAPSLRW
                     SYPLERALGHSLANVPALPGRTLVLVDRSGSMFYSRMSDRSELSRADAAAVFGTALALR
                     AADADLVEFGTSSNRVKYREGESVLKILERFGDLGGTDTTDAVRRHYRKHDRVLIVTDE
                     QYAYNRHGDPTEQVPEHVPVYTWNLAGYRAGHGPSGKADRHTFGGLSDAAFRMVPLLEA
                     ARDADWPWAA"
     gene            5287..5934
                     /locus_tag="B1H29_RS27880"
                     /old_locus_tag="B1H29_27910"
     CDS             5287..5934
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007381192.1"
                     /locus_tag="B1H29_RS27880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_27910"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_055416314.1"
                     /transl_table=11
                     /translation="METIRPVPRTLLRDRAYEAIRDAIVAGEIEPGAVVRDADLAERLG
                     LSRAPVREAFSRLVDEGLLESKPQSYTRVTPVVAADVRDAAAVVGAVHELVTRVAVPRL
                     RQADLDAMRAANERFAAAVHAGDVDGALRADDELHHVLVRAAANRAAAATVARYTPLIR
                     RLERRRFGEGGTCRSAGLHEQLIAACAAGDTETALRVTADIWRGLEELADPD"
     gene            5958..6974
                     /locus_tag="B1H29_RS27885"
                     /old_locus_tag="B1H29_27915"
     CDS             5958..6974
                     /EC_number="3.5.99.7"
                     /GO_function="GO:0008660 -
                     1-aminocyclopropane-1-carboxylate deaminase activity
                     [Evidence IEA]"
                     /GO_process="GO:0042217 - 1-aminocyclopropane-1-carboxylate
                     catabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010352423.1"
                     /locus_tag="B1H29_RS27885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_27915"
                     /product="1-aminocyclopropane-1-carboxylate deaminase"
                     /protein_id="WP_055416313.1"
                     /sec_met_domain="PALP (E-value: 2e-48, bitscore: 164.0,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLSSYERYPLLLGPSPVHRLERLTEHLGGASLWAKREDLNSGIA
                     YGGNKTRKLEYLVADALARGCDTLVSIGGVQSNHTRQVAAVAARAGLGCVLVQESWVDW
                     PDAVYDKVGNILISRLAGADVRLVRAGFGIGFKESWEQALKEVEDAGGKPYAIPAGASD
                     HPLGGLGFAGWAHEVAEQERELGVFFDTVVVCSVTGSTQAGMVAGFRALEEAGGRPRRV
                     IGVDASAEPARTRAQIARIAHRTGQLIGVTQELTEADVELDERYHAGTYGVPDATTLAA
                     MRLAARTEGMVTDPVYEGKSMAGLIDLVARSEIGGDATVLYAHLGGQPALNAYSALF"
     gene            7223..7801
                     /locus_tag="B1H29_RS27890"
                     /old_locus_tag="B1H29_27920"
     CDS             7223..7801
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019982870.1"
                     /locus_tag="B1H29_RS27890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_27920"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_055416312.1"
                     /transl_table=11
                     /translation="MAQVRPMRADARRNHERLLEAAAVAFGEHGEGASLDDIAKRAGVG
                     TGTLYRHFPTRQALLEAAYLDRIEAIAARADLIAAERAPGDALLEWLNELAAGMIQVRG
                     MKALLGTAVTAGGSAVDTACGDCVRGAAGRLVRAARDAGALRRDVEPIEVLRLVHGVVT
                     ASESAEGAAGGDGESVRRLLSLVWGGLRA"
     gene            complement(7855..9063)
                     /locus_tag="B1H29_RS27895"
                     /old_locus_tag="B1H29_27925"
     CDS             complement(7855..9063)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1296: tellurium
                     resistance protein, TerD"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010037930.1"
                     /locus_tag="B1H29_RS27895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_27925"
                     /product="TerD family protein"
                     /protein_id="WP_079160509.1"
                     /transl_table=11
                     /translation="MTPGSNIPLSAARVTVDVAAPVRLDVSGLLLTADGKVRSDDDFIF
                     YNQPTGQGVTYRSGGGTAPDAIVVDTSAVPPGIEKIVVTASPDAAGQTFQGVEPTATVR
                     NADDNSVLATFTPPQLGSETALVIVEVYLRNGVWKARAVGQGYSNGLAGIATDFGVTVE
                     EPAAPAAQPAPPQPQAVTPPPPPAAAPTMPSAPPTAPAAPPAPAPGAGKINLDKGRVSL
                     QKNQTVSLVKGGRPMLSQVKMGLGWEPAYRGKDIDLDASVIAYGPQRNHIDSCYFGKLS
                     IVGGAVKHSGDNLTGEGGGDDEVITVDLGRLPQEVSGLVFTVNSFSGQKFTEVAKAYCR
                     LMDAATGEELVRFDLTSAEPQTGVMMAKLIRQYSGEWEMTAMGDFVKSRTVRGMVKPSA
                     KAL"
     gene            complement(9148..9369)
                     /locus_tag="B1H29_RS27900"
                     /old_locus_tag="B1H29_27930"
     CDS             complement(9148..9369)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448219.1"
                     /locus_tag="B1H29_RS27900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_27930"
                     /product="hypothetical protein"
                     /protein_id="WP_055416310.1"
                     /transl_table=11
                     /translation="MPRPHGFAYTATANGTVHITHHQHSATTLNGPRAARFLEEVATGD
                     PQLVMARWTGNYKHGNERTARNHPRNRR"
     misc_feature    9701..9710
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            9866..9976
                     /locus_tag="B1H29_RS37650"
     CDS             9866..9976
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016638602.1"
                     /locus_tag="B1H29_RS37650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_107095211.1"
                     /transl_table=11
                     /translation="MKKAYEAPTLVRLGSFRQKTGLLQRNGNDRLILSKN"
     gene            10001..11857
                     /locus_tag="B1H29_RS27905"
                     /old_locus_tag="B1H29_27935"
     CDS             10001..11857
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656043.1"
                     /locus_tag="B1H29_RS27905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_27935"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_055416309.1"
                     /sec_met_domain="Asn_synthase (E-value: 3e-43, bitscore:
                     147.6, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEVHESAEPGRGDAHFAVLPDCEEAAAAARFFRRPGTRVLAHAS
                     GRPWLIGRWSGTEITTARAGRTALATVGWCPADRQRLERQAARMRDLTELDALARSLPG
                     SFHLVATHDGQLRMQGTASGLRLVFHARIGGVHVAATSADLLATALGSRPDTGRLAVRL
                     LWPVPHPLYETSVWEGVDAVSPEEALIVSADGHRVRRSRWWRPPEPTRTLAQGAPAVRE
                     ALAEAVDVRTRPGGVVSCDLSGGLDSTSVCFLAARSDASVVAATWPGRDPADTDLAWAR
                     QAAEHLPKVDHVVWDAEGSALVYSDLLGIDDLLDEPTIGVMDRSRVLQHLPWLAARGSR
                     VHLTGIGGDHVAWCSEAYYHGLLRTRPLFAMRQLRGFRALWNWPLGATARALADSRAYP
                     DWLAHSAGRLRAPMPETSVTAGLGWGMSPRLFPWMTSEAERLARRALLDAAARAEPLHA
                     DRGLHTDLELIRTCTRIIRQWERMAARAGLPMASPYLDDRVIEACLAVRPDERVTPWRY
                     KPLLTEAMRGVVPEECLRRANKAEASMDASDGLRRHRGDLMTLWTGSHLEGLGLVDGGE
                     LRRLAQRPSAPGLRDAILYSTIACEVWLRSRDRAAHPGAAVG"
     aSDomain        11886..12059
                     /aSDomain="Lasso_Fused_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing fused peptidase in a lasso
                     peptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_B1H29_RS27910_Lasso_Fused_RRE.1"
                     /evalue="6.50E-09"
                     /identifier="RREFam003.1"
                     /label="B1H29_RS27910"
                     /locus_tag="B1H29_RS27910"
                     /protein_end="58"
                     /protein_start="0"
                     /score="26.8"
                     /tool="antismash"
                     /translation="MTLRFDTDVATAETEYGTVLLDQRSGEYWELNPTGALVVRTLLDG
                     GDEAAAVTALVAR"
     aSDomain        11886..12134
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_B1H29_RS27910_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="1.00E-29"
                     /identifier="RREFam002.1"
                     /label="B1H29_RS27910"
                     /locus_tag="B1H29_RS27910"
                     /protein_end="83"
                     /protein_start="0"
                     /score="93.4"
                     /tool="antismash"
                     /translation="MTLRFDTDVATAETEYGTVLLDQRSGEYWELNPTGALVVRTLLDG
                     GDEAAAVTALVARFEIDRDRAEQDVTALVGDLRAAGLV"
     gene            11886..12140
                     /locus_tag="B1H29_RS27910"
                     /old_locus_tag="B1H29_27940"
     CDS             11886..12140
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004946593.1"
                     /locus_tag="B1H29_RS27910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_27940"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_055416308.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 2.6e-27,
                     bitscore: 93.4, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 1.7e-06,
                     bitscore: 26.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.3e-16, bitscore: 59.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLRFDTDVATAETEYGTVLLDQRSGEYWELNPTGALVVRTLLDG
                     GDEAAAVTALVARFEIDRDRAEQDVTALVGDLRAAGLVS"
     gene            12137..12571
                     /locus_tag="B1H29_RS27915"
                     /old_locus_tag="B1H29_27945"
     CDS             12137..12571
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010987089.1"
                     /locus_tag="B1H29_RS27915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_27945"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_055416307.1"
                     /sec_met_domain="PF13471 (E-value: 1.4e-26, bitscore: 91.5,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPSALDRPTGVPLARRLAARLVLVPALALSFLPPRHIRAVLER
                     VRRGARPATPAQAAAAREALCAVSLRCAGPRGCLPRSLGAALLCRLHGVWPTWCTGVRK
                     VPPFSAHAWIEAGGRPVGEGVPDDYFARLVTVAAVRRAGP"
     gene            12682..14427
                     /locus_tag="B1H29_RS27920"
                     /old_locus_tag="B1H29_27950"
     CDS             12682..14427
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988508.1"
                     /locus_tag="B1H29_RS27920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_27950"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_055417674.1"
                     /transl_table=11
                     /translation="MFRLTSGHRPGIAVATGLTLAASALGLAQPLVAKHVVDSSVRGEV
                     LWPFLLLLSGLFVAEAAAGATGRFLLDRMGEDVIRMVRHGLVSRLLRLEMREADRRRRG
                     DLVSRVTADTTLLRDVVSQALVDLLTGCLVSAGALLLMLWLDPLLLLLVVVTVALAAVV
                     VSTLLKGMRAASEQMQSSVGTIAAELERALGALPVVRVYRAEEREARRIGERVDSAHRS
                     GVRAAKLAAVMSSAVELAVQGSFLLVLVVGGMRVGSGGADSLGDLVAFLLYASYLVMPL
                     SSVFRAIGLIQRGAGAYLRIDEALALPQEPAQEPGPALPGTPPATPRSPAHALELTDIR
                     FAYVPDRPVLRGATFTVPHHGLVALVGRSGAGKSTLFSLIARLYDPDAGSIRFDGRPAT
                     ALTRRQCRAGIALVDQNTHVLEGTLRENITYAVPDATDDDILRVVRLTRLEHVVRRLPG
                     GLDGRLGDQGGTLSAGERQRVALARALLARPRLLLLDEHTSHLDAVNETALTRTLSDVT
                     RDCAVLVIAHRLSTVRHADRIVVLEDGRTVASGRHDRLLATSAAYRELAATHVLHGRVP
                     ENGER"
     gene            complement(14517..15506)
                     /locus_tag="B1H29_RS27925"
                     /old_locus_tag="B1H29_27955"
     CDS             complement(14517..15506)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019329272.1"
                     /locus_tag="B1H29_RS27925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_27955"
                     /product="zinc-dependent alcohol dehydrogenase family
                     protein"
                     /protein_id="WP_055416306.1"
                     /sec_met_domain="ADH_N (E-value: 7.1e-33, bitscore: 111.5,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.9e-13, bitscore:
                     49.3, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAAVIESVGRAVVTEVPDPTPGPREVVVEVAACGLCGTDLHILQ
                     GEFAPKLPIVPGHEFAGEVVGVGAQVTEVSLGDQVAVDPSLYCYECRQCRTGHNNLCER
                     WAAIGVTTAGGAAKYAVAPVANCVKLPEHVRTQDAALIEPLSCAVRGYDVLQSRLGAHV
                     LIYGSGTMGLMMLELAKRTGAAGVDMVDVNPARLETARALGVSASAANPDELDRPQGWD
                     LVIDATGNAAAIQDGLGRVAKAGTFLQFGVADYATRVQIDPYRIYNQEITITGSMAVLH
                     SYERAAELFANGVLDPDVFISDRLPLDRYPQALEQFASGVGRKIVVLP"
     gene            complement(15503..16396)
                     /locus_tag="B1H29_RS27930"
                     /old_locus_tag="B1H29_27960"
     CDS             complement(15503..16396)
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011028038.1"
                     /locus_tag="B1H29_RS27930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_27960"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_079160510.1"
                     /transl_table=11
                     /translation="MSATAVRPATTATTGTTGAKPARARRKAGAGLGLVAWLAGIVFFL
                     PIAWMALTSFHSEEDAATNPPSFAASLTLDGYREFFGAGGGASPWPALINSAVASIAST
                     LFVLVLALPAAYALSIRPVKKWTDVLFFFLSTKMLPVVAGLLPIYLFAKNTDMLDNIWL
                     LVLLYTSMNLPIAVWMMQSFLAEVPVAIIEAARVDGARLPTILARVVAPIALPGIAATS
                     LICFIFSWNELLFARVLTGVVAETAPVFLTGFITSQGLFLAKVCAASLVISLPVLAAGF
                     AAQDKLVQGLSLGAVK"
     gene            complement(16393..17337)
                     /locus_tag="B1H29_RS27935"
                     /old_locus_tag="B1H29_27965"
     CDS             complement(16393..17337)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016436171.1"
                     /locus_tag="B1H29_RS27935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_27965"
                     /product="sugar ABC transporter permease"
                     /protein_id="WP_055416305.1"
                     /transl_table=11
                     /translation="MTATTTAPSAAPDHTRPTVRPPSSRLKGWATRAPLLPALIFMIVV
                     TQLPFVATLVISFFDWNALYPDARHFTGFGNYGDVLSDPALRKSVWTTILLTVGVVLAS
                     LVLGLALALLLDRRFKGRGVVRTLLIAPFLVVPVAAALLWKHVLYNPEYGLLNGLLHYV
                     GGPQPDWISNTPLLAVEASLVWQWTPFMMLILLAGLQSRDQQQIEAARVDGASDWQIFV
                     HLTLPHLRRYLELGALLGSIYIVQNFDAVFTITSGGLGTANLPYTVYQSFYQAHENGLA
                     SAAGVLVVIGSIIIATFALRVVSSLFREEVGRA"
     gene            complement(17334..18704)
                     /locus_tag="B1H29_RS27940"
                     /old_locus_tag="B1H29_27970"
     CDS             complement(17334..18704)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006381715.1"
                     /locus_tag="B1H29_RS27940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_27970"
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="WP_055416304.1"
                     /transl_table=11
                     /translation="MRTQSRWRPRATLAMAAAGTLLAPLLSGCWVGAGGAGSGGNAINV
                     LMVNNPQMVELQKLTADHFTEETGIKVNFTVLPENDVRDKISQDFANQAGQYDVATLSN
                     YEIPIYARNEWLQPMDSYVAEDPAYDEKDILGPMRESLTGDDGKLYGQPFYGESSFLMY
                     RKDVFAQEGLTMPEHPTWTQVADLAEKLDGAQPDMKGICLRGLPGWGELMAPLTTVVNT
                     FGGTWFDTDWQARLDSPEWQKATKFYVDLVREHGQSGAAQSGFAECLNNMTQGNVAMWY
                     DATSAAGSLESANSPVKGKMGYAPAPVEKTESSGWLYTWAWGIQKASRNADKAWEFVSW
                     ASSKEYEQLVGDEIGWSNVPAGKRASTYENPAYREEAAAFQEMTREAIEGARPGDPGVQ
                     PRPAPGIQFVGIPEFTDLGTKVSQEISAAIAGRQSVEEALKKSQQLAEKISEEYEGR"
     misc_feature    18713..18727
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.34"
                     /tool="antismash"
     gene            complement(18814..19584)
                     /locus_tag="B1H29_RS27945"
                     /old_locus_tag="B1H29_27975"
     CDS             complement(18814..19584)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019067511.1"
                     /locus_tag="B1H29_RS27945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_27975"
                     /product="DeoR/GlpR family DNA-binding transcription
                     regulator"
                     /protein_id="WP_055417672.1"
                     /transl_table=11
                     /translation="MGTRTAEERQREIVRVARATGSVDVTALAADLGVAKETVRRDLRA
                     LEDHGLVRRTHGGAYPVESAGFETTLAFRATSQVPEKRRIAAAAAELLGDAETVFVDEG
                     FTPQLIAEALPRDRPLTVVTASLPVAGALAEAGDTSVLLLGGRVRSGTLATVDHWTTKM
                     LAGFVIDLAYIGANGISREHGLTTPDPAVSEVKTQAIRAARRTVFAGTHTKFGAVSFCR
                     FAEVGALEAIVTSTLLPTAEAHRYSLLGPQVIRV"
     gene            complement(19857..20666)
                     /locus_tag="B1H29_RS27950"
                     /old_locus_tag="B1H29_27980"
     CDS             complement(19857..20666)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (52-173). E-value:
                     2.1e-11. Score: 35.3. Matches aSDomain:
                     nrpspksdomains_B1H29_RS27950_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020114323.1"
                     /locus_tag="B1H29_RS27950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_27980"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_055416303.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.2e-06, bitscore:
                     25.7, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 5.4e-07,
                     bitscore: 27.7, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAPRTVLLTGAAGGLGTLMRDLLPDHGYTLRLLDLRPIEGEPDA
                     VVADLADRAAVREAVRGVDAIIHLAGISLEAPFEKILKANIEGTYNLYEAAREEGVGRI
                     VFASSNHAVGYTPRPGGDDPLIPVDTPRRPDTFYGLSKSFGEDLAQFYWDKHGMETVSV
                     RIGSCFPEPTSVRMLSVWMSPADGARLFHAALTAENVGHTVVHGSSANTRLWWDLTSAR
                     ALGYEPRDDSEPYAEKLIAEQGDLDPDNPAHARLGGHFVTDPPIWPY"
     aSDomain        complement(20148..20510)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B1H29_RS27950_NAD_binding_4.1"
                     /evalue="2.10E-11"
                     /label="B1H29_RS27950_NAD_binding_4.1"
                     /locus_tag="B1H29_RS27950"
                     /protein_end="173"
                     /protein_start="52"
                     /score="35.3"
                     /tool="antismash"
                     /translation="RAAVREAVRGVDAIIHLAGISLEAPFEKILKANIEGTYNLYEAAR
                     EEGVGRIVFASSNHAVGYTPRPGGDDPLIPVDTPRRPDTFYGLSKSFGEDLAQFYWDKH
                     GMETVSVRIGSCFPEPT"
     CDS_motif       complement(20607..20651)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B1H29_RS27950_0001"
                     /evalue="2.10E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="B1H29_RS27950"
                     /protein_end="20"
                     /protein_start="5"
                     /score="10.8"
                     /tool="antismash"
                     /translation="TVLLTGAAGGLGTLM"
     misc_feature    20873..20886
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.67"
                     /tool="antismash"
     gene            20919..21878
                     /locus_tag="B1H29_RS27955"
                     /old_locus_tag="B1H29_27985"
     CDS             20919..21878
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019329278.1"
                     /locus_tag="B1H29_RS27955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_27985"
                     /product="5-dehydro-4-deoxyglucarate dehydratase"
                     /protein_id="WP_055416302.1"
                     /transl_table=11
                     /translation="MTSAPLAARLTRPGGPLFFPVTAYGPGGETDLDAYRAHVRRGVEA
                     GAAAVFACCGTGEFHALTPEEFQACVRAAVEETAGRVPVLAGAGYGTALAVRYARLAEE
                     AGADGLLAMPPYLVLAGQEGLLRHYREVAAATSLPVVVYQRDNAVFTPESVVELARTDR
                     IVGLKDGLGDLDLMQRIISAVRTEAPGGDFLYFNGLPTAEQTQLSYRALGVTLYSSAAF
                     CFAPEIALAFHRALRSGDEATVHRLLDGFYRPFVELRARGRGYAVALVKAGVRLRGLDV
                     GEVRPPLQEPTEEHVKQLAQVIERGYALLDGVAEEGAE"
ORIGIN
        1 tgctggagca ggtgtccgac gcgatgatgc ggctggacga ccagttccgg ctgctcgaac
       61 ccatcggcct cgtcgagtac cagccggtcg acgaggacct gatgaccgac gcggacgagg
      121 agcccgcggc gcccgtcgac gagaccgacg tcgcccgcta cggcatggtg cggctcaccc
      181 cgctcggcct gtacggcctg cgcgcccggc tcctggaggc cggtttcgac gcccccgccg
      241 tcggcgacct ctccgacaag ggcgccgacg cgctgctcga cggcacggcg cccttcccgc
      301 cggccgcggc ccacgcggag accgagctgt ggctggccgg gcggagcccc ctcaccgcgg
      361 cccgcgaact gctggcggcg gcacgtggct cggacaccgg cgcgcccctg cgccggctgc
      421 gctgccagca ggcgctgtcc ctggtcggcg ccgaggcgga gcccgcgctg cgggaggtcc
      481 tcgacgacgc cgaactgggc gggctggcca gggtctggct gaccgagcac ggcgcccggg
      541 acgttcccgc cccgccgcag gagatggtct tctggctgac catcgacacc gtggcggcac
      601 agctcgccgc cgaggggaac tccgaggagc tgcgtgccct ggtggagggg ctggcccggc
      661 agcacagcgg gttcttcgac acggtgtggc gggtcgccca tccggccacg ccggacgtgc
      721 tggaggcgat ggggcggctg catcccgaca agaaggtcgc caaggaagcc cgcaaggcgg
      781 cgttcaaggc ccggtcgcag caaggcggct gacggcgggc ggcgccgggg aaacggcgct
      841 ccgccgccgg acgcgggcgg tggcgcggcc cggcgccggc ggggtgccgc cgggcccttc
      901 cgtccggttg ggccctccgg tgcagcggtc ttcggtggct cgtgtgtgcc gtcggggttg
      961 gtgtgcggct cggtgtggct ggaggggttg gtgtgcggct cggcgcgggc ggggtggggt
     1021 cgggtccttc cgtccggttg ggccctccgg tgcagcggtc ttcggtggcg cgtgtgtggg
     1081 ccgtcggggt tggtgtgcgg ctcggtgtgg ctggaggggt tggtgtgcgg ctcggcgcgg
     1141 gcggggtggg gtcgggtcct tccgtccggc tgggccctcc ggtgcagcgg tcctgggtgg
     1201 cgcgtgtgtg ggccctcgcg gccggaagtt cggccaggca tatccggagc ggccaggcat
     1261 atccggagcg gccaggcatg atcggagtgg cccggcatga caggagcggc ccggcgaccg
     1321 gcgggcggac cggcgtcgcg gtgtgccggg tgtgggaggt ggcggcccgg cgccggcggg
     1381 gtgccgccgc ctccttccgt gccgccgcgc ccccaccctg gaacgtccgc ggttgcgcgg
     1441 gctgccccgt aggcgccgcg ctcagttcaa ccggcgttca gccgcgggcg caaccgtggc
     1501 gccggacaga ggtccgccac cctccacggc acgcccaccg tcacaggaga ctccatgtcg
     1561 ctcacccgca gggacttcgc cagccgatcc gcgctcaccg gcgccggagt cgtgctggcg
     1621 ggcagcgtcg gcgccctcgc caccgccccg aacgccctcg cgtccacgga caccgagagc
     1681 gcgggggagg agcacgaccg gggccgcgga cgcgggcacg accacggtgg ggtcggttac
     1741 ggaccactgg tccccgaccc ggacggcatc ctcgccctgc ccgccggctt ccggtacgag
     1801 atcatcacct actgcggccg gaccaggctg gagtcgggcg agtacacccc ctccaaccac
     1861 gacggcaccg cggccttcga cggcccgcgc ggcaccaccc tcctggttaa caaccacgaa
     1921 ctgggcggcc accgcgacga ctgggcccac cccgtcccgc tcgccgaggg cctcgtctac
     1981 gacccggccg cggccggcgg ctgcacggtc gtcgaggtcc gccgcggcgg ccacgtcgcc
     2041 gagtgggtcg gcatcgccgg taccgcccag aactgcgcgg gcggcagcac cccgtggggc
     2101 acctggctga cctgcgagga gaccgaggac aaggccggcg aggaggggat gaccaaggac
     2161 cacggctacg tcttcgaggt cgaccccgag gaccggcgcg ccaaccgcga ccccgagccg
     2221 atcaaggcgc tcggccgcta cgcccacgag gccgtcgtcg tcgaccccaa gcggggccac
     2281 ctctacctca ccgaggacgc ctccggcccc aacggcctct tctaccgctg ggccccgccg
     2341 gagggcttcc ggcacggccg cggccgactg cgcaccctcg ccgacgacgc cggggtcctc
     2401 caggccttca agtgcttcga ctccggcggc aagttcgtcg acgacctctc ccgcgcgacg
     2461 aggaccggca cggtctacgg cgtcgactgg gtcgacgtcc ccgaccgcga cgcggagaac
     2521 acctccgtgc gcaggcagtt caccgacgga caggtcaccc gcgcccgcaa gctggagggc
     2581 atgtggtggg ccgacggcgg cgcgtacatc gtctcctcct tcgcccgtga cgagagcccc
     2641 ggccggccgc acgacggcca ggtctggttc tacgacccgg ggcgccgcac cctcacgctc
     2701 aaagtcctcc tcggcgtcaa ccccgacccg tcggcggacg gcgccttcga cggtcccgac
     2761 aacatcaccg tctcgccgta cggcggcctc gtcatcgccg aggacggcga cggcgtccag
     2821 cacctgttcg gcgccacgga cagcggccgc acctacccca tcgcccgcaa cgacctgaac
     2881 gtcggcagcg aagacgatcc cgagtacagc gagttcgccg gcgtcacctt ctcgcccgac
     2941 gggaagaccc tctacgccaa tatccaggac cccggcatca tggtggccat caccgggccc
     3001 tggaagcggc agaagcgccg gtgattaatt cgctcgcccg agcgacggcc gcccttttag
     3061 agtgatgaac gtccaggtgc gaaggcagga cctacttcca ctcataatgg ggcggtcacg
     3121 ggttcgagtc ccgtcaccgg cacaacacgc cggtgtagct cagggggcag agcaccttgt
     3181 cggttccgcc gacctgaact ctggacgctc agaacttcat gcacctcccg gtgcgcgggc
     3241 cgcggctact tcgttgtcat cgaatccgac gccgcggccg tcttgatctc gggaggcgcg
     3301 gcagatggtg ggtgcccggt gcgcaggcgg cggatacttc cttgaccgga cgttgcgggg
     3361 ttcgaatcct cgtcaccgac ttcgggtcgg tgcagctcaa tggcagagca tccggatgtt
     3421 cccgtcgccg attcggacct cgggcaccct ccttccgccg tgcctccctc cgaaacgaat
     3481 tcgggggaat tcaccatggc gcgattcaac accaaggccg cgaaggcgca gcccacctcg
     3541 cgcgtgacgt cgacgggccg cgtgctgcgc acctacgagg gcggccgggg ccgcgagcgc
     3601 gacccgcgtt ccgaactctt cctcctcgcg gtcgccaacc tcgtgtcgca gcagaccttc
     3661 tacgagtccg gcgcggcccg cgacgaccgg ttcgccgcgc tcgtgcgcga gctcgccgtc
     3721 tccgacccgt cgtggacggc cggcctgctg ggctggctgc gcggcgaggg caacctgcgc
     3781 accgcctccg tcgtcggcgc cgccgagtac gtcaaggccc gtctcgacgc cggtgccacc
     3841 gacggcccgg ccaaccggca ggtcgtcgcc tcagtcctcc agcggcccga cgagcccggc
     3901 gagctgctcg cgtactggac cgcgacgtac gggcgcgccg tgccgaagcc ggtcaagcgg
     3961 gggatcgccg acgccgtacg ccggctctac cacggcaagt cgctgctgaa gtacgacacc
     4021 gcgtccaagg ggtaccgctt cggcgacatc ctcaacctgg tgcacgcggc gccggacccg
     4081 gacaagccgt ggcagggcga gctgttccag tacgccctcg accgccggca caacccggac
     4141 acggcggtgc cgcccgcctc gaaccgcgtc ctcaccgcgc accgcgagct gatggcgctg
     4201 cccgtcggcc ggcggcgggc ggtcgtcacc gcgcccgacg gtgccgagcg gctcgcggcg
     4261 gcgggcatca cgtgggagat gctggccggc tggctccagg ggccgatgga caaggcggcc
     4321 tgggaggccg tgatcccgtc catgggggcc atggcgctcg tccgcaacct gcgcaacttc
     4381 gacgaggccg gcgtgtccga cgaggtcgcg gcgcgggtgg cggcgcggat cagcgacccg
     4441 gaccaggtgg cgcgctcgcg gcagttcccc ttccgctacc tcgccgcgta ccggcacgcg
     4501 ccgtcgctgc gctggtcgta cccgctggag cgggcgctcg gccactcgct ggccaacgtg
     4561 cccgcgctgc ccggccggac gctggtcctc gtggaccgct cgggctcgat gttctactcg
     4621 cggatgtcgg accgttcgga gctcagccgg gccgacgcgg cggcggtctt cggcacggcg
     4681 ctcgcgctgc gggcggccga cgcggacctc gtcgagttcg gtacgtcgag caaccgcgtg
     4741 aagtaccgcg agggcgagtc ggtgctgaag atcctggagc gcttcggcga cctgggcggc
     4801 accgacacga ccgacgcggt ccgccggcac tacaggaagc acgaccgggt gctgatcgtc
     4861 accgacgagc agtacgcgta caaccggcac ggcgacccga ccgagcaggt cccggagcac
     4921 gtgccggtct acacctggaa cctggccggg taccgggcgg gccacggccc gtcgggcaag
     4981 gcggaccggc acaccttcgg cgggctctcg gacgcggcct tccggatggt tcccctgctc
     5041 gaagccgccc gggacgccga ctggccctgg gcggcctgag cccggacccg gtccggggcc
     5101 ggagcggacc cggacccgga cccggacctg gaccgggttc ggatcccgga gcggaccggg
     5161 cccggccccg gacgccgggc ccggcccgcc gtccgtcgtg gcccgccgtc cgtcgtggcc
     5221 cgcacctgtg cgcaggtgcg ggccgcactc ttgtggcccc ggggatctga catctaacat
     5281 ttcaatgtgg agaccatccg acccgtaccc cgcaccctgc tccgcgaccg cgcctacgaa
     5341 gccatccggg acgccatcgt ggccggggag atcgaaccag gcgccgtcgt gcgggacgcc
     5401 gacctggccg agcgactggg gctgtcccgg gccccggtgc gcgaggcgtt ctcccggctc
     5461 gtggacgagg gtctgctgga gagcaagccg cagagctaca cccgggtcac cccggtcgtg
     5521 gccgccgacg tgcgagacgc cgccgccgtc gtcggcgccg tgcacgaact ggtcacgcgg
     5581 gtcgccgtgc cccggctgag gcaggcggac ctcgacgcga tgcgcgcggc caacgaacgg
     5641 ttcgcggcgg ccgtccacgc gggcgacgtc gacggtgccc tgcgcgccga cgacgagctg
     5701 caccacgtcc tcgtccgcgc cgccgccaac cgggccgccg ccgccaccgt cgcccgctac
     5761 accccgctca tccgccggct ggagcgccgc cgcttcggcg agggcggcac ctgtcgttcg
     5821 gccgggctgc acgagcagct catcgcggcc tgcgcggcag gtgacacgga gacggcgctc
     5881 cgtgtgacgg cggacatctg gcggggcctc gaagagctcg ccgaccccga ctgatccggc
     5941 ccgacccggg aggaaccgtg tccctttcct cgtacgagcg ctacccgctg ctcctcggac
     6001 cttcgccggt gcaccggctg gaacgcctca ccgagcacct cggtggagcc tcgctctggg
     6061 ccaagcggga ggacctgaac tccggcatcg cctacggcgg caacaagacc cgaaagctgg
     6121 agtacctcgt cgccgacgcg ctcgcccgtg gctgcgacac cctcgtctcg atcggcggcg
     6181 tgcagtccaa ccacacccgc caggtcgcgg ccgtcgccgc ccgggcgggc ctcggctgcg
     6241 tgctcgtgca ggagagctgg gtggactggc ccgacgccgt gtacgacaag gtgggcaaca
     6301 tcctgatctc ccggctcgcc ggggccgatg tgcggctggt gcgggccggg ttcggcatcg
     6361 gcttcaagga gagctgggag caggcgctca aggaggtcga ggacgcgggc ggcaagccgt
     6421 acgccattcc ggcgggcgcc tccgaccatc cgctcggcgg gctgggcttc gccggctggg
     6481 cccacgaggt cgccgagcag gaacgggaac tgggcgtctt cttcgacacc gtcgtcgtct
     6541 gctcggtgac cgggtcgacc caggccggca tggtcgccgg cttccgcgcc ctggaggagg
     6601 cgggtggccg gccccggcgg gtgatcggcg tcgacgcgtc cgcggagccc gcccgcaccc
     6661 gggcgcagat cgcccggatc gcgcaccgca cggggcagct catcggcgtg acgcaggaac
     6721 tgacggaggc ggacgtcgaa ctggacgagc ggtaccacgc gggtacgtac ggcgtccccg
     6781 acgccaccac gctcgccgcg atgcggctcg ccgcccggac cgagggaatg gtcaccgacc
     6841 cggtctacga ggggaagtcg atggcggggc tgatcgacct ggtcgcgcgc tcggagatcg
     6901 gcggcgacgc caccgtgctc tacgcccacc tcggcgggca gccggcgctg aacgcgtaca
     6961 gcgccctgtt ctgagccggc gtcggcccgc cgggcgcgga ccggcgcgcg tcgcaccgag
     7021 cggcctcgcc ggccgcctac cgcgcgaaca ccggcgacac cgaggtcatc gtcgacgggc
     7081 aggagatccg gcccgcacgg aaggggctcc cctcccgtcc gggcgggccg ttcgcgcggg
     7141 cagggcaggg cagggcacgg cagtggcgcg cgggcgcgcg gtagggtgcg gcgagaatcc
     7201 tctgtgggca gggagtagtg ggatggcgca ggtcaggccc atgcgcgcgg atgcccgccg
     7261 aaaccacgag cggttgctgg aagccgcggc ggtggcgttc ggggagcacg gggagggtgc
     7321 ctccctggac gacatcgcca agcgggcggg agtcgggacc ggcacgctgt accggcattt
     7381 cccgacgcgg caggcgttgc tggaggccgc ctacctggac cggatcgagg cgatcgcggc
     7441 gcgggccgac ctgatcgcgg ctgaacgggc gccgggcgac gcgttgctgg agtggctgaa
     7501 cgaactcgcg gccgggatga tccaggtgcg cgggatgaaa gccctgctgg gcaccgccgt
     7561 gacggccggt ggctcggcgg tggacacggc ctgcggcgac tgtgtgcggg gcgcggccgg
     7621 ccggctggtg cgggcggcgc gggacgcggg ggcgctgcgg cgggacgtcg agccgatcga
     7681 ggtgctgcgg ctggtgcacg gggtggtgac ggcgtccgag tcggccgagg gggcggccgg
     7741 gggcgacggg gagtccgtac gccggcttct gtcgctggtg tggggcgggt tgcgggcgta
     7801 gacggccgcg gtggggcgcc cgcagtgccg ggggcgcccc accgaaccgg ccgcttacag
     7861 cgcctttgcc gacggcttca ccatgccccg gaccgtgcgg gacttgacga agtcgcccat
     7921 ggcggtcatc tcccactcgc cggagtactg gcggatcagc ttcgccatca tcacgccggt
     7981 ctgcggctcg gcgctggtga ggtcgaagcg gaccagttcc tcgccggtcg cggcgtccat
     8041 gaggcggcag taggccttgg cgacctcggt gaacttctga ccggagaagg agttgaccgt
     8101 gaagaccagg ccgctgacct cctgcggaag ccggccgagg tcgacggtga tcacctcgtc
     8161 gtcaccgccg ccctcgccgg tgaggttgtc gccggagtgc ttgacggcgc cgccgacgat
     8221 ggacagcttg ccgaagtagc aactgtcgat gtggttgcgc tgcgggccgt aggcgatgac
     8281 cgaggcgtcc aggtcgatgt ccttgccgcg gtacgccggc tcccagccga ggcccatctt
     8341 gacctgggag agcatcgggc ggccgccctt gacgagggag acggtctggt tcttctggag
     8401 gctgacccgg cccttgtcga ggttgatctt cccggcgccc ggggcggggg ccggcggggc
     8461 ggccggcgcc gtcgggggag cggagggcat cgtgggcgcg gcggcgggcg ggggcggcgg
     8521 ggtgaccgcc tggggctgcg gcggggcagg ctgggcggcc ggggcggcgg gctcctccac
     8581 cgtgacgccg aagtccgtcg cgatgccggc cagtccgttg gagtagccct ggccgaccgc
     8641 gcgggccttc cagacgccgt tgcgcaggta gacctccacg atcaccagcg cggtctcgct
     8701 gccgagctgc gggggcgtga aggtggcgag gacggagttg tcgtccgcgt tgcggacggt
     8761 ggcggtcggt tcgacgccct ggaaggtctg cccggcggcg tccgggctgg cggtgacgac
     8821 gatcttctcg atgcccggcg gcacggcgga ggtgtcgacc acgatcgcgt ccggggcggt
     8881 gccgccgccg gagcggtagg tcacgccctg gccggtgggc tggttgtaga agatgaagtc
     8941 gtcgtcggag cgcaccttgc cgtcggcggt gagcagcagg cccgatacgt cgagccgcac
     9001 gggcgcggcg acgtccaccg tcacgcgggc ggcggagagg gggatgttcg agccgggggt
     9061 catagctgtc atgccgggtg aacgagcgag ggcgttttac cgttccctta cccggccgcc
     9121 aatcgggtca gggcccgggc ggtgcggtca gcggcggttg cgggggtggt ttcgcgcggt
     9181 gcgttcgttg ccgtgtttgt agttgcccgt ccagcgggcc atcaccagtt gggggtcgcc
     9241 ggtggcgacc tcttcgagga agcgggcggc gcgggggccg ttcagtgtgg tggcggagtg
     9301 ctggtggtgg gtgatgtgga cggtgccgtt cgcggtggcg gtgtaggcga agccatgggg
     9361 tcggggcatg cggggatcgt aggaggggcg ggggcggcgg gcccaggggt tttcgcccgc
     9421 gccgcctcct tcccgtcccc gtctccgggg gccgaccggg cgggtggcgg ccgggaggcc
     9481 cggcgggccc gggcgaggaa ccacgcgccg ggagcggtgc accgcacccg tctccggtgc
     9541 cggcggttgc gtccctggcg cggtgtgcgc cgggcggcgc ccccacaccc cgcgtgcacg
     9601 gtccggtcgg cgccctgacc ggtgcgccga ccgaagtgcg caggtcggaa ggtgtccgcc
     9661 ggcttttcgc ctccccacgc cacccccctt cgattccgac gaaggcggcc ggcagcgcgc
     9721 atgccgcccc gttcaggccc tttgaggtct gttgatatga cttgtgccgg acgtcttgtc
     9781 cgcgtcacgc gccgccccgc tagctggtga caccgccgcc ggccgaaagg aagaccgacg
     9841 gcaccactca catcgaggtg atggcatgaa gaaggcgtac gaggccccga cgctcgtccg
     9901 gctggggtcg ttccggcaga agaccgggct gctgcagcgc aacggcaacg accgtctgat
     9961 cctcagcaag aactgacggc ggccggcacg tagcgatttc atgtccgaag tgcacgagag
    10021 tgcggaaccg ggccgcggcg acgcccactt cgcggtcctt cccgactgcg aggaggcggc
    10081 cgccgcggcc cgcttcttcc gccgacccgg tacccgcgtc ctggcccacg cctcgggccg
    10141 gccctggctg atcggccgtt ggtccggcac ggagatcacc acggcccggg ccggccgaac
    10201 ggccctcgcc accgtcgggt ggtgcccggc cgaccgacag cggctcgaac gccaggccgc
    10261 ccgaatgcgc gacctcaccg aactcgacgc cctggcccgg tccctgccgg gcagtttcca
    10321 cctggtggcc acccacgacg ggcagctcag gatgcagggc accgcctccg ggctgcggct
    10381 ggtcttccac gcgcggatcg gcggtgtcca cgtggccgcg accagcgcgg acctgctcgc
    10441 cacggccctg ggcagccggc cggacaccgg tcgactggca gtccggctcc tgtggccggt
    10501 gccgcatccg ctgtacgaga cctcggtctg ggagggagtc gacgcggtct ccccggagga
    10561 ggccctgatc gtctccgcgg acggacaccg ggtccgcagg tcacgctggt ggcggccccc
    10621 ggagccgacc cgcaccctgg cgcagggcgc gccggccgtc cgcgaggcgc tggccgaggc
    10681 cgtggacgtc cggacccggc cgggcggcgt ggtgagctgc gacctgtccg gcggactgga
    10741 ctccacctcc gtctgcttcc tggccgcccg ctccgacgcc tccgtggtgg ccgcgacctg
    10801 gcccggacgg gaccccgcgg acaccgacct ggcctgggcc cggcaggcgg cggagcacct
    10861 gccgaaggtc gaccacgtgg tctgggacgc ggaggggtcc gccctggtct actcggacct
    10921 gctcggcatc gacgacctgc tcgacgagcc gaccatcggg gtgatggacc gctcacgcgt
    10981 cctgcagcac ctgccgtggc tggccgcacg cggcagccgg gtgcacctca ccggcatcgg
    11041 cggcgaccac gtcgcctggt gctcggaggc gtactaccac ggactgctgc gtacccgccc
    11101 gctgttcgcg atgcgccagt tgcggggctt tcgcgccctg tggaactggc cgctcggcgc
    11161 gacggcgcgt gccctcgccg actcccgcgc ctacccggac tggctggcgc actccgccgg
    11221 ccggctgcgc gcccccatgc cggagacctc ggtgaccgcg ggtctcggct gggggatgtc
    11281 cccccgcctg ttcccctgga tgacctccga ggcggagcgg ctggcccgcc gagccctgct
    11341 ggacgcggcc gcgcgggccg agccgctgca cgcggaccgg ggcctgcaca ccgacctgga
    11401 gctgatccgc acctgcacgc gcatcatccg ccagtgggag cggatggcgg cccgggcggg
    11461 actcccgatg gcgtcgccgt acctggacga ccgcgtgatc gaggcctgcc tcgcggtgcg
    11521 gccggacgag cgcgtcacgc cgtggcggta caaaccgctg ctcaccgagg cgatgcgcgg
    11581 tgtcgtcccg gaggagtgcc tgcggcgtgc caacaaggcc gaggcgtcga tggacgcgtc
    11641 ggacggactg cgtcgccacc ggggcgacct gatgactctg tggaccggtt cccacctgga
    11701 aggcctcggc ctggtggacg gcggggaact gcgccggctc gcgcagcggc cctccgcgcc
    11761 gggcctgcgg gacgcgatcc tctactcgac catcgcctgc gaggtgtggc tgcgctcccg
    11821 ggaccgcgcg gcgcatcccg gagccgccgt cggatgacgg acgacagcag aaaggcgccg
    11881 acgccatgac actccgattc gacaccgacg tcgccaccgc ggagaccgag tacggaaccg
    11941 tgctcctcga ccagcgcagc ggtgagtact gggaactcaa ccccacgggc gcgctggtgg
    12001 tgagaaccct cctggacggc ggcgacgagg ccgccgccgt cacggcgctc gtcgcgcggt
    12061 tcgagatcga ccgcgaccgc gcggagcagg acgtgacggc actggtgggc gacctccggg
    12121 ccgcggggct ggtctcatga ccacgcccag cgccctggac cggcccaccg gagtccccct
    12181 cgcccggcgg cttgccgccc gcctcgtcct cgtccccgcg ctggccctgt cgttcctgcc
    12241 gccgcggcac atccgcgccg tactggaacg ggtgcgccgt ggcgcgcggc ccgccacccc
    12301 ggcacaggcg gcggcggccc gggaggcgct gtgcgcggtg agcctgcgct gcgccgggcc
    12361 gcggggctgt ctgccgcggt cgctgggggc agccctgctg tgccggctgc acggcgtctg
    12421 gcccacctgg tgcaccgggg tgcgcaaagt gccgccgttc tccgcccacg cctggatcga
    12481 ggccggcggc cgacccgtcg gggagggcgt cccggacgac tacttcgcgc ggttggtgac
    12541 ggtggccgcg gtgcggcggg cggggccgtg agcgacacgg tcgtcgcgga cgacgccccg
    12601 gccggcaccg gcccggcagg ccgcggggcg cagccttccg cgccgtccgc gagtcggacg
    12661 acgaggggct cggtcgcctc cttgttccgt ctgacgtccg gtcaccggcc cggcatcgcc
    12721 gtggcgaccg ggctgaccct ggccgcgtcg gcgctgggac tcgcccagcc gctcgtcgcc
    12781 aagcacgtcg tggactccag cgtccgcggc gaggtgctgt ggccgttcct gctgctcctg
    12841 tccgggctct tcgtcgccga ggccgccgcg ggagcgaccg gccggttcct gctggaccgc
    12901 atgggcgagg acgtgatccg catggtgcgt cacggactcg tctcgcggct gctgcggctg
    12961 gagatgcggg aggcggaccg gcgccgccgc ggcgacctgg tctcccgggt caccgccgac
    13021 accaccctgc tgcgggacgt cgtgtcacag gcactggtcg acctcctcac cggctgtctg
    13081 gtgtcggccg gggcgctgct gctgatgctg tggctggacc ccctgctgct gctcctcgtc
    13141 gtggtgacgg tcgccctcgc cgcggtcgtc gtcagcacgc tcctgaaagg catgcgggcg
    13201 gcgtcggagc agatgcagtc ctccgtgggc accatcgccg cggaactgga gcgcgccctc
    13261 ggcgccctgc cggtggtgcg ggtgtaccgg gccgaggagc gcgaggcgcg ccgcatcggc
    13321 gagcgggtgg actcggccca ccggtcgggc gtccgggcgg cgaaactggc cgcggtcatg
    13381 agcagcgccg tcgaactcgc ggtccagggc tccttcctgc tcgtcctggt cgtgggcggc
    13441 atgcgggtcg ggagcggggg agcggactcc ctcggagacc tggtcgcctt cctgctgtac
    13501 gcgtcgtacc tggtcatgcc cttgtcgtcg gtgttccgcg ccatcggcct gatccagcgc
    13561 ggcgcgggtg cctacctgcg gatcgacgaa gccctcgccc ttccccagga acccgcgcag
    13621 gagcccggcc cggcgctccc cggcacaccg ccggccaccc cgcggtcccc ggcccacgcg
    13681 ctggaactga ccgacatccg cttcgcctac gtcccggacc ggccggtcct gcgcggggcg
    13741 accttcaccg tgccgcacca cggactcgtg gccctcgtcg gccgctcggg agccggcaag
    13801 agcactctct tctcactgat cgcgcgcctc tacgaccccg acgccgggag catccggttc
    13861 gacggccgcc cggcgacggc cctgacccgc cggcagtgcc gcgcgggcat cgccctcgtg
    13921 gaccagaaca cccacgtact ggagggcacg ctccgggaga acatcaccta cgcggtcccc
    13981 gacgccaccg acgacgacat cctccgcgtc gtacggctga cccgcctcga gcacgtggtg
    14041 cggcggctgc ccggggggct ggacggcagg ctgggcgatc aaggcggcac gctctccgcg
    14101 ggagaacgcc agcgcgtcgc cctggcccgt gccctgctcg cccgtccgcg gctgctcctg
    14161 ctcgacgaac acacctcgca cctggacgcc gtcaacgaga cggcactcac ccggacgctg
    14221 agcgacgtca cccgggactg cgcggtcctc gtcatcgcgc accgcctctc cacggtgcgg
    14281 cacgccgacc ggatcgtcgt cctcgaagac ggccgcacgg tggcctccgg ccggcacgac
    14341 cggcttctcg ccaccagcgc ggcctaccgc gaactggccg ccacacacgt cctgcacggc
    14401 cgcgtccccg agaacggcga gcggtgatcc accgagccgg ccggcggccg ccgcgtcccc
    14461 gggccgcgac ggcgcgtgcc gcggccaggg gacgcggcgg ccctaccggg cactcctcac
    14521 gggagtacga cgatcttcct gccgacgccg gaggcgaact gctccagtgc ctgcggatac
    14581 cggtcgaggg gcagccggtc gctgatgaag acgtccgggt cgaggacgcc gttcgcgaag
    14641 agctcggccg cgcgctcgta gctgtgcagg acggccatgg agcccgtgat ggtgatctcc
    14701 tggttgtaga tgcggtacgg gtcgatctgc acgcgcgtcg cgtagtcggc cacgccgaac
    14761 tggaggaacg tgcccgcctt ggcgacccgc cccaggccgt cctggatggc cgccgcgttg
    14821 cccgtcgcgt cgatgacgag gtcccagccc tgggggcggt ccagttcgtc cgggttcgcg
    14881 gccgacgcgg agacgccgag ggcgcgggcc gtctccaggc gggccgggtt gacgtcgacc
    14941 atgtcgacgc cggccgcgcc ggtccgcttg gccagctcca gcatcatcag gcccatcgtg
    15001 ccggagccgt agatcaggac gtgcgcgccg aggcgggact ggaggacgtc gtagccgcgg
    15061 accgcgcagg acaggggctc gatcagggcg gcgtcctggg tgcggacgtg ctcggggagc
    15121 ttcacgcagt tcgccaccgg cgccaccgcg tacttcgcgg cgccgcccgc cgtcgtcaca
    15181 ccgatggccg cccagcgttc gcagaggttg ttgtggccgg tgcggcattg gcggcactcg
    15241 tagcagtaga gggaggggtc caccgcgacc tggtcgccga gcgacacctc cgtgacctgg
    15301 gcgccgacgc cgaccacctc gccggcgaac tcgtggcccg gcacgatcgg gagcttgggc
    15361 gcgaactcgc cctggaggat gtgcaggtcc gtgccgcaca ggccgcaggc ggcgacctcc
    15421 acgacgacct cgcgcggccc tggcgtcggg tccgggacct cggtgacgac ggcgcggccc
    15481 acggactcga tgacggcggc cttcatttca cggctcccaa cgacaggccc tggaccagtt
    15541 tgtcctgggc ggcgaacccc gcggcgagca ccggcaggga gatgacgagc gacgcggcgc
    15601 acaccttggc caggaagagg ccctggctgg tgatgaagcc ggtcaggaag acgggggcgg
    15661 tctcggcgac cacgcccgtc agcacccggg cgaagagcag ttcgttccaa ctgaagatga
    15721 agcagatgag cgaggtcgcg gcgatgccgg ggagggcgat cggggcgacc acccgcgcca
    15781 ggatcgtcgg cagcctcgcg ccgtccaccc gggccgcctc gatgatcgcg accgggacct
    15841 cggccaggaa ggactgcatc atccagaccg cgatcggcag gttcatcgag gtgtagagga
    15901 ggaccagcag ccagatgttg tccagcatgt ccgtgttctt ggcgaacagg tagatcggca
    15961 gcaggcccgc caccaccggc agcatcttgg tggagaggaa gaagaacagg acgtccgtcc
    16021 acttcttcac cgggcggatg gacagggcgt acgcggcggg cagggccagg accaggacga
    16081 agagggtcga ggcgatggac gccaccgccg agttgatcag cgccggccag gggctcgcgc
    16141 caccgcccgc gccgaagaac tcgcggtagc cgtccagggt gagggaggcc gcgaaggacg
    16201 gcgggttggt ggccgcgtcc tcctccgagt ggaaggaggt cagcgccatc cacgcgatcg
    16261 gcaggaagaa gacgatgccg gccagccagg ccaccaggcc cagtccggcc cccgccttgc
    16321 ggcgggctcg tgcgggcttg gcgccggtgg tgccggtggt ggcggtggtg gcgggtcgta
    16381 cggcggtggc actcatgcgc ggccaacctc ctcgcggaac agggacgaca ccacgcgcag
    16441 cgcgaaggtg gcgatgatga tcgagccgat gaccaccagg acgcccgcgg ccgaggcgag
    16501 gccgttctcg tgggcctggt agaagctctg gtagacggtg tagggcaggt tggccgtgcc
    16561 caggccgccg gacgtgatcg tgaagaccgc gtcgaagttc tggacgatgt agatcgagcc
    16621 gagcagggcg ccgagttcca ggtagcggcg caggtggggg agggtgaggt ggacgaagat
    16681 ctgccagtcg ctcgcgccgt ccacccgggc ggcctcgatc tgctgctggt cccggctctg
    16741 cagcccggcc agcaggatga gcatcatgaa gggcgtccac tgccacacca gtgaggcctc
    16801 gaccgcgagc agcggggtgt tggatatcca gtccggctgc gggccgccga cgtagtgcaa
    16861 caggccgttg agcaggccgt actcggggtt gtagaggacg tgcttccaca ggagcgccgc
    16921 cgccaccggg accaccagga acggggcgat cagcagggtg cgcaccacgc cccggccctt
    16981 gaacctgcgg tccagcagca gggcgagtgc caggccgagg accaggctgg ccaggaccac
    17041 ccccaccgtc agcaggatcg tcgtccacac cgacttgcgc agggccgggt cggacaggac
    17101 gtcgccgtag ttgccgaatc cggtgaagtg ccgggcgtcc gggtagaggg cgttccagtc
    17161 gaagaaggag atcaccaggg tcgccacgaa ggggagctgg gtgaccacga tcatgaagat
    17221 cagggcgggg aggagggggg cccgggtggc ccagcccttc agccgggagg acggcgggcg
    17281 gacggtgggg cgggtgtgat cgggtgcggc cgagggggcc gttgtggtgg cggtcatcgt
    17341 ccctcgtact cctcggagat cttctcggcg agctgctggg acttcttcag ggcctcctcg
    17401 acggactgac gtccggcgat ggccgcgctg atctcctggg agaccttggt gccgaggtcg
    17461 gtgaactcgg ggatgccgac gaactggatg ccgggcgcgg ggcgcggctg cacgcccgga
    17521 tcaccgggcc tggcgccctc gatggcctcc cgggtcatct cctggaaggc ggcggcctct
    17581 tcgcggtagg ccgggttctc gtacgtcgac gcgcgcttgc cggccggcac gttggaccag
    17641 ccgatctcgt cgccgacgag ctgctcgtac tccttgctgg acgcccagga gacgaactcc
    17701 cacgccttgt cggcgttgcg ggaggccttc tggatgcccc aggcccaggt gtagagccag
    17761 ccggaggact cggtcttctc cacgggggcg ggcgcgtagc ccatcttgcc cttgacgggg
    17821 gagttggccg actccaggga tccggcggcg gaggtggcgt cgtaccacat ggcgacgttg
    17881 ccctgcgtca tgttgttcag gcactcggcg aaacctgact gggcggcgcc ggactggccg
    17941 tgctcgcgga cgaggtcgac gtagaacttc gtcgccttct gccactcggg ggagtccagt
    18001 cgcgcctgcc agtccgtgtc gaaccaggtg ccgccgaagg tgttcacgac cgtcgtcagg
    18061 ggcgccatca gctcgcccca gccgggcagg ccgcgcaggc agatgccctt catgtccggc
    18121 tgggccccgt cgagcttctc ggcgaggtcg gccacctggg tccaggtggg gtgctcgggc
    18181 atcgtcaggc cctcttgggc gaacacgtcc ttgcggtaca tcaggaagga ggactcgccg
    18241 tagaagggct ggccgtagag cttgccgtcg tccccggtga gggactcgcg catcggcccc
    18301 aggatgtcct tctcgtcgta cgccgggtcc tcggcgacgt aggagtccat cggctgcagc
    18361 cactcgttgc gggcgtagat cggtatctcg tagttggaga gggtggcgac gtcgtactgg
    18421 cccgcctggt tggcgaagtc ctggctgatc ttgtcgcgga cgtcgttctc cggcaggacg
    18481 gtgaagttca ccttgatgcc ggtctcttcg gtgaagtggt ccgcggtgag cttttgcagc
    18541 tcgaccatct gcgggttgtt gaccatcagg acgttgatgg cgttgccgcc ggacccggcg
    18601 ccgcccgccc cgacccagca gccggagagc agcggggcga gcagcgtccc tgcggcggcc
    18661 atggcgagcg tggctcgcgg cctccatcgg ctctgggttc gcatggatcg ctcctgaaca
    18721 tgtggggaag taatggggag tgaaggggag ttatcgggag ttatggggca ggggtgggcg
    18781 cgtgggtgcc ctccagtgac gtggttcggc ccgtcagacg cggatgacct gcgggccgag
    18841 cagggagtag cggtgggcct cggccgtggg cagcagcgtg ctggtcacga tcgcctccag
    18901 ggcgccgacc tcggcgaacc ggcagaagct gaccgccccg aacttggtgt gcgtgcccgc
    18961 gaacacggtg cggcgggcgg cgcggatcgc ctgggtcttg acctcgctga ccgccgggtc
    19021 gggtgtggtg aggccgtgtt cccgggagat gccgttggca ccgatgtacg ccaggtcgat
    19081 gacgaaaccg gccagcatct tggtcgtcca gtggtcgacg gtggcgagcg tgcccgagcg
    19141 gacccggccg ccgagcagca ggacggaggt gtcgccggcc tcggcgagcg cgccggcgac
    19201 cggcagggag gcggtgacca cggtcagcgg ccggtccctg ggcagtgcct cggcgatgag
    19261 ctggggggtg aagccctcgt cgacgaagac cgtctccgcg tcaccgagca gttcggccgc
    19321 cgcggcggcg atccggcgct tctcgggcac ctggctggtg gcgcggaagg cgagcgtggt
    19381 ctcgaacccg gcgctctcca cggggtaggc gcctccgtgg gtgcggcgga ccaggccgtg
    19441 gtcctccagg gcgcgcaggt cgcgtcgtac ggtctccttg gcgacgccca ggtcggccgc
    19501 gagcgcggtg acgtcgaccg agccggtggc gcgggcgacc cgcacgatct cgcgctggcg
    19561 ttcctccgcc gtcctcgtgc ccatgccgaa cacctgcctc accgcctcgt cgccgcgttc
    19621 ttgcccgttc gggcccgtgg ggcccatggg ggaagttcta cagcggccgt gcggcactga
    19681 ccaggcctgt tgcggacccg atactgcccg attgtgcccg ttgtggccgg cgggcgcccg
    19741 tcgcggacct ggcagtcagc ggtgcggcgc gtgagaacgg gcagtgcgga tgcccgtata
    19801 ccgaagcggg cgggcccgtt cggtgcccgc cccgcctcgt gatcgaccgg atccggtcag
    19861 tacggccaga tcggggggtc ggtcacgaag tggccgccga ggcgggcgtg cgccgggttg
    19921 tccgggtcga ggtcgccctg ctcggcgatg agcttctcgg cgtacggctc cgagtcgtcc
    19981 cggggttcgt aaccgagcgc ccgcgcggag gtgaggtccc accacagccg ggtgttggcg
    20041 gaggaaccgt ggacgacggt gtgcccgacg ttctcggcgg tcagggcggc gtggaagaga
    20101 cgggcgccgt cggccgggct catccacacc gagagcatgc gcacgctggt cggctcgggg
    20161 aagcaggagc cgatgcggac cgagacggtc tccatgccgt gcttgtccca gtagaactgg
    20221 gcgaggtcct cgccgaagga cttggacagg ccgtagaagg tgtccgggcg gcgcggggtg
    20281 tcgaccggga tgagggggtc gtcgccccca gggcgcgggg tgtagccgac ggcgtggttg
    20341 gaggaggcga agacgatacg tccgacgcct tcctcgcggg cggcctcgta gaggttgtac
    20401 gtcccctcga tgttggcctt caggatcttc tcgaaggggg cttccaggga gatgcccgcc
    20461 aggtggatga tcgcgtcgac gccccggacc gcctcgcgca cggcggcccg gtcggcgagg
    20521 tcggcgacga cggcgtccgg ctcgccctcg atcgggcgca ggtcgagcag gcgcagcgtg
    20581 tacccgtggt cgggcagcag gtcccgcatc agggtgccga ggccgccggc ggcgccggtg
    20641 agcaggacgg tgcggggagc gggcatcctc gggactccta ggtctcctgt gggtccggct
    20701 gaacgtctgg aggtccgccg aatcggcggc cgtgtgtcag ccgtatgtgt gagcggctgg
    20761 cgttcatatg cgtggacacg ctaaagaacc ggtggtcacc cgtcaagagg cggcctgctt
    20821 gacggtgttc gcggggcggc ttagcgtggt cgcgttcaga aatatggaca cagatcatga
    20881 atatgacaca gaccatggat atggaatggg gagcgcccgt gacctcagcc cctctcgccg
    20941 cccggctcac cagacccggc ggaccgctgt tcttccccgt cacggcctac ggccccggcg
    21001 gtgagaccga cctcgacgcc taccgcgcgc acgtgcgccg aggggtcgag gccggggccg
    21061 ccgccgtgtt cgcctgctgc ggcacgggcg agttccacgc gctcaccccc gaggagttcc
    21121 aggcctgcgt ccgggcggcc gtcgaggaga ccgcggggcg ggtgcccgtc ctggcgggcg
    21181 cgggctacgg caccgccctc gccgtgcgct acgcccgcct cgccgaggag gccggggccg
    21241 acggactgct cgccatgccg ccgtacctgg tgctggccgg ccaggagggg ctgctgcggc
    21301 actaccggga ggtggccgcg gcgacctccc tgcccgtggt cgtctaccag cgcgacaacg
    21361 ccgtgttcac accggagagc gtggtcgaac tggcccgcac cgaccggatc gtcggcctca
    21421 aggacgggct cggcgacctc gacctcatgc agcggatcat cagcgccgtg cgcaccgagg
    21481 cccccggcgg cgacttcctc tacttcaacg ggctgccgac cgccgagcag acccagctct
    21541 cctaccgcgc gctcggcgtc accctctact cgtccgccgc gttctgcttc gcccccgaga
    21601 tcgccctcgc cttccaccgg gcgctgcgct cgggcgacga ggccaccgtg caccgcctgc
    21661 tggacggctt ctaccggccg ttcgtcgaac tccgcgcgcg gggccgcggg tacgccgtcg
    21721 ccctggtcaa ggcgggcgta cggctgcgcg gcctggacgt gggggaggtg cggccgccgt
    21781 tgcaggagcc gaccgaggag catgtcaagc agctcgccca ggtgatcgag cggggttacg
    21841 cgctgctcga cggcgtggcc gaggagggcg ccgagtgaag acgtcggcat tcgtctaccc
    21901 ctgggacgtc aacggcgacc cggacgcgcc cgcgtccgtc gcggggctcg gcgtcgagca
    21961 ggtgacgctc gccgccgcct accactccac ccgggccctc accccccgcc acccgcgcca
    22021 ccgcgtcgtc accgccgagt acgccgccgt cctctacccg ccggacgccc gctggcgggg
    22081 acgggagccg cgcccgtacg aggccggtga ctgggcgccc ggcgacgcgt ggggcgaggc
    22141 cgccgccgcc ctcgcggacg ccgggctgga agtgcacacc tgggtcgtcc tcgcccacaa
    22201 ctcccgcctc ggcgccgagc atccgcacac ctcggtcgtc aacgcctacg gcgaccgcta
    22261 cccctgggcg ccctgtatcg cgcagcccgc cacgcgcgcg tacctcaccg acctggccgc
    22321 cgaggcggcg gtgcggcccg gggcgcgcgg caccgagctg gagtccctcg gctggtacgg
    22381 gctcgcccac ctgcacgccc acgacaagac cggcggggtc ggcctcgggg acgccgggca
    22441 gtacctgatg tcgctgtgct tctgccccga ctgccgggcc ggctacggcg gacagggcct
    22501 cgacgccggc gaactggccg ccgccgtacg cgccgcgctc gagccggtct ggcggggcac
    22561 ggcgccgtcg g
//
