LOCUS       NZ_CP019724            22742 bp    DNA     linear   CON 01-JUN-2024
DEFINITION  Streptomyces pactum strain ACT12 chromosome, complete genome.
ACCESSION   NZ_CP019724
VERSION     NZ_CP019724.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces pactum
  ORGANISM  Streptomyces pactum
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8550793)
  AUTHORS   Xue,Q., Yan,X., Jia,L. and Yan,H.
  TITLE     Streptomyces pactum ACT12 Genome sequencing and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8550793)
  AUTHORS   Xue,Q., Yan,X., Jia,L. and Yan,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-FEB-2017) College of Life Sciences, Northwest A&F
            Unversity, No.22 Xinong Road, YangLing, Shaanxi 712100, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: AUG-2016
            Assembly Method                   :: SMRT v. 2.3.0
            Assembly Name :: version 2.3.0 of the PacBio Single Molecule Real
            Time
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002005225.1-RS_2024_06_01
            Annotation Date                   :: 06/01/2024 05:58:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,315
            CDSs (total)                      :: 7,221
            Genes (coding)                    :: 6,992
            CDSs (with protein)               :: 6,992
            Genes (RNA)                       :: 94
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 229
            CDSs (without protein)            :: 229
            Pseudo Genes (ambiguous residues) :: 0 of 229
            Pseudo Genes (frameshifted)       :: 84 of 229
            Pseudo Genes (incomplete)         :: 195 of 229
            Pseudo Genes (internal stop)      :: 15 of 229
            Pseudo Genes (multiple problems)  :: 62 of 229
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:20:20
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2145490
            Orig. end                         :: 2168232
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP019724.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Northwest A&F Unversity.
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22742
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="16"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22742
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22742
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12742](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12742)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    445..463
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.49"
                     /tool="antismash"
     gene            complement(459..2702)
                     /locus_tag="B1H29_RS08870"
                     /old_locus_tag="B1H29_08865"
     CDS             complement(459..2702)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014150654.1"
                     /locus_tag="B1H29_RS08870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_08865"
                     /product="MMPL family transporter"
                     /protein_id="WP_079160107.1"
                     /transl_table=11
                     /translation="MATFLSRLGRFAFRRRRLVALLWAVLLVGTGVLAGRAPAPPPNDF
                     SMPGTEAQQAYDLLERSFPELNADGATARVVFRAEDGKVTDAETRRAVQETVRELGDGP
                     QAVRVTDPYATRSVSEDGSTAYAQVSYEVPASELEERSREALQDTVEQAGSPELTVEVG
                     GNAVKAMAGGHSSEALGLAVAAVVLVITFGSLLAAGLPLLTAVLGVGIGGLAIKVLAEP
                     LGLGSTTSGLATMIGLAVGIDYALFVVSRHRAELARGRGREEAAAHAVGTAGSAVVFAG
                     LTVIIALAGLGVVGIPLLTQMGLAAAGTVVIAVLIAVTLIPALLSLCGRRIGPARPRPR
                     RAAGRPKPAMGVRWARFVVRRPVTVLLGATALLGAIAVPAAALEMGLPGDESKPASTTQ
                     RRAYDLVAEGFGPGYNGPLTMVVQTEGGGSAQEAARDVAGEISAREDVAAVGQPRLSRS
                     GETAVLTVVPATAPASAETADLVHALREPALVSDSHAHVLVAGSTAMNVDVSQKLSDAL
                     LPYLGLVVGLAFLLLIAVFRSLLVPLKAALGFLLSVLAGLGAVVAVFQWGWLSSLFGVA
                     VPGPVMSMTPIFMVGVVFGLAMDYEVFLVTRMREAYVHGQSPRDSVVSGFEHSARVVTA
                     AAVIMVSVFAAFMGSDEQMLKTIGFGLAAAVLFDAFVVRMAIVPAVLALLGRRAWRLPR
                     RLDRFVPDLDVEGERLERGLGGRTASAPGASLDAGPGPAVETAGSGGGRGSGG"
     gene            complement(2879..3037)
                     /locus_tag="B1H29_RS39230"
     CDS             complement(2879..3037)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B1H29_RS39230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_234393080.1"
                     /transl_table=11
                     /translation="MASGIHGQRLFVSPGLDLVAVHFGSQVISPDVPVAPLVQAFLRIG
                     VRLGATR"
     misc_feature    3487..3503
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 22.56"
                     /tool="antismash"
     misc_feature    complement(3488..3503)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 21.54"
                     /tool="antismash"
     gene            3934..>4092
                     /locus_tag="B1H29_RS08880"
                     /old_locus_tag="B1H29_08875"
                     /pseudo=""
     CDS             3934..>4092
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973104.1"
                     /locus_tag="B1H29_RS08880"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_08875"
                     /product="MerR family transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTADDSFGRLDDDYPAYTMGRDAEMLGTTPGFLRAVGEARLITPL
                     RSAGGHRR"
     gene            4194..4364
                     /locus_tag="B1H29_RS38020"
     CDS             4194..4364
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B1H29_RS38020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_159027804.1"
                     /transl_table=11
                     /translation="MVRKVPSAHVFGVGVLLCCCAAVLLCCCAAVLLCCWNQATTSALR
                     MLREAYIGWMA"
     gene            complement(4764..5324)
                     /locus_tag="B1H29_RS08885"
                     /old_locus_tag="B1H29_08880"
     CDS             complement(4764..5324)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061717.1"
                     /locus_tag="B1H29_RS08885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_08880"
                     /product="hypothetical protein"
                     /protein_id="WP_199832385.1"
                     /transl_table=11
                     /translation="MLPEVRPHVSAPLANQLEHQLGLASDPEARHLDVERVAGIAVVAA
                     AHSGGYASIGHLLGLLAALPAPTEAGERFWSDLWRSSGTAYLLPANLKAEVLQALAGEG
                     TSLARQILSAVEEMTPPQRVAAGEVIGQALAESDHLPDLKTQVIGELWLRDLELTAWRV
                     LHADRRSDDPAGRKAFLEAWTSV"
     misc_feature    5456..5471
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.92"
                     /tool="antismash"
     gene            complement(5940..7907)
                     /locus_tag="B1H29_RS08890"
                     /old_locus_tag="B1H29_08885"
     CDS             complement(5940..7907)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024846.4"
                     /locus_tag="B1H29_RS08890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_08885"
                     /product="FAD/NAD(P)-binding protein"
                     /protein_id="WP_055419721.1"
                     /transl_table=11
                     /translation="MNENHRAHGADESGPAPYRADNPSIAVIGCGPRGTSVLERIAANT
                     HLLAPEERFDIHVIDPYPVGAGRVWRQGQSPLLWSNTRADECTLFTDDTVTCQGPAVEG
                     PTLEQWARDLAAGRLHLPPGYQPAPGTREEAARVHAGWFATRKLTGDYLAWFFWRSVAA
                     VAPRAHVRTHQASVLSLGDLPDGRQRVRLDDGETVDVDLVILAQGHFQVKPQGPEPRLA
                     QHAAAHHLSYQPTAYTSDISLDAFPAGEPVLMRGFGLTFIDIMVLLTEGRGGRFRREPS
                     GELRYVPSGREPTLYVGSRRGVPYRSKFAYVLSGPPPRVPRYFSPADFADHSLDFASDL
                     WPALARELTVAGYRELAHSHPQRLGVDAGEFLDRLDAAQWRSPEFKDLIEQAVPDSRDH
                     IDVDGLDRPLANRRFPDAAALRAWMLHYLADDLERGRNPRYSAHLAVYHAIFSISQALW
                     AVVQRGEVEPGNGSHSMTAFFDFCRFRTSGPPGPRLEQLLALARAGVVDFVGANMKVTC
                     RGGVFEARTSSLDRVVQARALIEARLPGRALTRVADPLLLHLVGEREIREQVQTDPTTG
                     RRQPTGLIDTRGARPLGPDGSPHPRRFVTSPGDFPRPRTNDPFLHQSDAVAREALRALV
                     EARSGSRRRASPPSPTSHVY"
     gene            complement(7919..9685)
                     /locus_tag="B1H29_RS08895"
                     /old_locus_tag="B1H29_08890"
     CDS             complement(7919..9685)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019544853.1"
                     /locus_tag="B1H29_RS08895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_08890"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_055419722.1"
                     /transl_table=11
                     /translation="MKQAGRVRTRDLVRYMRGHALAMALAAVLSLVAAGGTLLQPVLVR
                     SVIDAISASRSTAASTVALVALLVGAAVINGFRDYMLRRVGEGVVLRIRQRLAGHVLRL
                     PVAEYDSRRTGDLLSRIGSDSSMLRSVVTSGLFEIFTGTLMIIGAAVAAFLVDPLLFAV
                     TAGGLLAGLAGAAVIAHRTRPASEQAQMLLGEMTSGLERAIRGVRTIRAARGEQRETEA
                     IAHSARRAYGMGLRLARLQAFTVPVAHIATQGVFLLVLGVGGARVAAGGLSVGDLVAFV
                     LFLFFLIMPVGQLIGAYSQLQTGLGALQRIEDVLRVPTETEGDVVRVGPPRESRGATPV
                     FGAGAVPALVFDRVTFGYGEGETVVEDISFTVSQGTRTALVGPSGAGKSTLLALAERFY
                     EVRSGAIRLSGADIREVSRDELRSRLGYVEQEAPILAGTLRENLSLSAPGLSDDELTDV
                     LRRVNLDEIVKRSPLGLDAQVGEGGVLLSGGERQRLAIARTLLAAPPILLLDEPTSNLD
                     ARNEQAFRAAIDAVPTDHTLLIVAHRLATVVDADQIVVVDQGRVVGTGTHHELIESSTL
                     YRDLASHQLLVA"
     CDS             complement(9811..9984)
                     /gene="allorf_2155301_2155474"
                     /locus_tag="allorf_2155301_2155474"
                     /protein_id="allorf_2155301_2155474"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MPHTAETTAVLSGKEVNTMANFVLGLQGMESEANNQDVLASSWTS
                     VCCKCSWVSTSC"
     CDS_motif       complement(9883..9984)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MPHTAETTAVLSGKEVNTMANFVLGLQGMESEAN"
                     /locus_tag="allorf_2155301_2155474_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9811..9882)
                     /prepeptide="core"
                     /locus_tag="allorf_2155301_2155474_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="0.30"
                     /molecular_weight="2350.6"
                     /monoisotopic_mass="2349.0"
                     /core_sequence="NQDVLASSWTSVCCKCSWVSTSC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MPHTAETTAVLSGKEVNTMANFVLGLQGMESEAN"
                     /leader_location="[9882:9984](-)"
                     /alternative_weights="2368.7"
                     /alternative_weights="2386.7"
                     /alternative_weights="2404.7"
                     /alternative_weights="2422.7"
     gene            complement(10001..12742)
                     /gene="lanKC"
                     /locus_tag="B1H29_RS08900"
                     /old_locus_tag="B1H29_08895"
     CDS             complement(10001..12742)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="B1H29_RS08900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_08895"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_324611026.1"
                     /sec_met_domain="micKC (E-value: 5.6e-230, bitscore: 764.4,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 6.4e-12, bitscore: 44.1,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 6.9e-10, bitscore:
                     36.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEAIRNLLLRNGGVDPMDLRYPAYCVANPRFYETPERVSLDEGWL
                     DYGSHIEAPSGWRRSIDEQWTRIQPPVGTPKLPVQGWKIHVSSTPENAVETLKKVAEYC
                     FRYTLHFKFLPHSLVMQARSAKYAPREASGKFITVYTRSPAELRRTLEDLDREIGGWPG
                     PYILSDLRWNEGPLYIRYGAFMLRFAHVDDGTQVAAIERPDGVLVADHREPRFVLPEWV
                     EVPDFLAESVHPRMSGEQPSEFPYDVLGVLHFSNGGGVYRARRLRDGTEVVLKEGRPYA
                     GLDRTGEDATARLRREYAVLSELQGLPGIPQVFDYHTLGGHEFLAMEHVYGQSLQSWVA
                     QNYLFLSGAGDGNETREYRDSVDVIMDQLEQAVRNVHERGYVFNDLHPGNVMIDEDLNI
                     SLIDFEAMRRESDDGPRPLGVPGFAAPDSLRGFQADRYSFNAIRLCLYFPLISLLALCP
                     AKAATFIDTARDRLELDEDVVTELRRSLAAPGPAQSGLRPADPELAFTTAAGPWHLQET
                     ALQASIRRTATPDRQDRLFPGDINQFFHGGGGIAFGAAGVIDALHTAGVTGLDPYVDWL
                     EHDTLTSRVPRLGLYDGAAGICRVLHRMGRADTAFAIYDKVAEESAGLFGTKLFDGLSG
                     IGLTSLDFYRRSAEPRFLDHAVRAAAVVEGAVDSGRFAVGAGSLSADSLLRDRNGNAVE
                     NFWGGLLYGWSGLALFMIRVYEVTGEERWRRAAATALHRDLDECEAMPDGTLQVKNGAR
                     VLPYLATGSAGVAMVGDLILRHVSDERIEGALPELSLACVTEFSIGAGLLNGRTGLIGA
                     LHQVKHRLDWPDVDKQVDEGVASLNLHALCDEFGLIFPGDQNLRASTDLGTGSAGVLQL
                     INVLAGRTSELLPFLGPEPWTPPHHEPSATAAGAGSTTSEHR"
     misc_feature    complement(11456..11458)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    12861..12877
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.6"
                     /tool="antismash"
     gene            12872..13876
                     /locus_tag="B1H29_RS08905"
                     /old_locus_tag="B1H29_08900"
     CDS             12872..13876
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1015: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024242.4"
                     /locus_tag="B1H29_RS08905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_08900"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_055419724.1"
                     /transl_table=11
                     /translation="MQAERLSIDQLPTSERFDRWDDEINSMPWPSHLAIDSPEHLHTLS
                     DRLDLGALRLFRLAQPPAAAMGTPPRGAAGDPDQYHLVLPLQGEVTLGDSTRSRVFTPG
                     DMFLADTSRRPVFHADVPRAHQHPDVVPSALVALRLQIPKELVPLPTDLMDSLVDTPLR
                     QHNVFGLTLSRLLVDLLRHPAGFSAAQGHRLSGVLLELLTGMLGSQTSEDATAEGTNDG
                     LFVRVQEFIQQRLGDPELTPAQVAAEHHISRRHLQRLFQQRGITVAASIRQQRLERACC
                     DLTAPHLATYPISAIAARWGFRHAADFSRAFRKAYGVAPSDFRLARTGSRCGP"
     misc_feature    complement(12883..12898)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.81"
                     /tool="antismash"
     misc_feature    13043..13045
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    13409..13411
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(14225..14239)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 25.66"
                     /tool="antismash"
     misc_feature    14226..14240
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 24.07"
                     /tool="antismash"
     gene            14331..15353
                     /locus_tag="B1H29_RS08910"
                     /old_locus_tag="B1H29_08905"
     CDS             14331..15353
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017944231.1"
                     /locus_tag="B1H29_RS08910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_08905"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_055419725.1"
                     /transl_table=11
                     /translation="MPEQTVRARPTLEAVAARAGVSRATASRVVNGGAGVRPALADKVR
                     RAVEELDYVPNHAARTLVTRRNGAVAVIIAEPEFRVFADPFFEQQVRGISRELTAHDMQ
                     LVLLWAEGSGDHERIARYLGGGHVDGALAFSLHDDRLPSLIARTGVPAVLGGRPAGSEH
                     LGIPLVDCDNRGGARDAVRHLVRLGRSRIAHISGPRDQTSAMDRIHGYRDVLVDADPRL
                     LCEGDFTEEGGARAMGELLDRCPGIDAVFASNDTMALGALRTLRERGARVPEDVAVVGF
                     DDMSSVVGAAEPALTTVRQDIEGMGRIMVKLLMRLLDAPGDEVPASVITRTTLVHRASA
                     "
     gene            complement(15551..18325)
                     /locus_tag="B1H29_RS08915"
                     /old_locus_tag="B1H29_08910"
     CDS             complement(15551..18325)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038210.1"
                     /locus_tag="B1H29_RS08915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_08910"
                     /product="glycosyl hydrolase"
                     /protein_id="WP_055419726.1"
                     /transl_table=11
                     /translation="MPTPRSRPAAAVVLAAALAAVGLGPAASPAAAATVPVGAGSYSDT
                     RPAGTTGPTTNTGAPVTPKVTQAAKGRPVPTNDWWSSLAFQRYGDNPYSTPMYGHPLTY
                     QAVSGGLEVGYPTSPAVVGEGRQYEYAHKRDLTLGLSGLNSPDTKADAWSDWTVTPYWS
                     DGSRTLRTTIGHGMPFVYAQGSGGNAQITTAATPAVFSDQGNVVGITVGGHHYALFAPT
                     GSDWNISGTTINAGLGGKDYFSLAVLPSTDALATFRKYAFSFVTGSQVDWSASGGTVGA
                     TYKLTTEAKEGTERGTLQALYRHQWLHTTDALTPYTYVSPRGTMKVREGTSFTTRQKAA
                     PVLPALPKTGAVDTSRLRGYLSEVADSSDPFSGASDTYWTGKALGKLAQLVPLADQIGE
                     TAVRDKLVGLLKGRLQEWFTAGGASEFSYDKDWKTLIGYPASYGSDAELNDHHFHYGYY
                     VYAAAIVAQYDASWAADSAWGGMVKALIRDTANPSRTDGAFPFLRGFDVYAGHSWASGH
                     QGFAAGNNQESSSESTNLSAALVLWGSATGNTELRDLGSYLLATEGEAIAQYWFDADQQ
                     VFPGSFTHDTVGMVWGSGGAYATWWTANPEEIHGINVLPVTAGGSPHLAGHKDAIRRNI
                     AEMERENGGPAVEWRDILWEFQSLADPASAKAKWDAGHAGYTPEQGESKAHTYHWITTL
                     DALGAPDPSVTGDLPTSAVFSKNGTRTYAAHNHGSTARTVTFSDGKKLTVPARSTATGT
                     GTDNGGEDPGPSTGNTFRLRSGGALTTATGGTAVSDTIPSAEGRNHDGTPNKPLVYEAE
                     GVNATLKAGASTTFRLPVDAGTAVGLGQQARISYDLTGDGTFDRTETYQYFATDPVTGW
                     EEYNQTRGLKAATGTLGNLSGGTVRLEVWSAIGNGSALLRTGGDTSVVVIPYE"
     misc_feature    complement(18443..18457)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 26.03"
                     /tool="antismash"
     misc_feature    18444..18458
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 26.03"
                     /tool="antismash"
     misc_feature    complement(18480..18494)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.99"
                     /tool="antismash"
     misc_feature    18615..18629
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.58"
                     /tool="antismash"
     misc_feature    complement(18628..18642)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.57"
                     /tool="antismash"
     misc_feature    18629..18643
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.57"
                     /tool="antismash"
     misc_feature    complement(18642..18656)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.01"
                     /tool="antismash"
     misc_feature    19021..19036
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.84"
                     /tool="antismash"
     misc_feature    complement(19332..19346)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 23.69"
                     /tool="antismash"
     misc_feature    19333..19347
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 24.07"
                     /tool="antismash"
     gene            19388..20281
                     /locus_tag="B1H29_RS08930"
                     /old_locus_tag="B1H29_08925"
     CDS             19388..20281
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016327509.1"
                     /locus_tag="B1H29_RS08930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_08925"
                     /product="DUF2637 domain-containing protein"
                     /protein_id="WP_055419728.1"
                     /transl_table=11
                     /translation="MYEEQTHQHLPYGEGSFPSAGGTGRHRAPEDAFQQHLQETLVPPE
                     PGWDPAEELAFLLQDAMEQQTGVVPGATDTSAIAPVPGTPLSNLQEITAELPPLRESPA
                     SHRRVRKPKVSRLRAASLFIAALAAVIAASVSLFGGMVAYEPLRLAAATRTRDSVVSWW
                     PLLVYGPWLVASLAVLRSALHQRRAVHSWAVVLLFSAIAMLLCIAQAPRTLSDGAAAAL
                     PGLASLVCFQQIVRQITLTRPPRRAVPRHRQRRPSAPEPGDEAGSTAAPDPLSLPHQRR
                     RPPHAPRSGAGPRGRS"
     gene            complement(20304..>20506)
                     /locus_tag="B1H29_RS39235"
                     /pseudo=""
     CDS             complement(20304..>20506)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034010.1"
                     /locus_tag="B1H29_RS39235"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="GTDIVSIHIFPHFIRGIHRPSDEAARIDGANSLHRLPENHHYIPF
                     LRMPSESRSVTSTTGTPMGPPN"
     gene            complement(20763..21245)
                     /locus_tag="B1H29_RS08935"
                     /old_locus_tag="B1H29_08930"
     CDS             complement(20763..21245)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019075395.1"
                     /locus_tag="B1H29_RS08935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_08930"
                     /product="DUF6299 family protein"
                     /protein_id="WP_055419729.1"
                     /transl_table=11
                     /translation="MPVRSATRTRVTATAAVKAAAAAAAGAALLLLSAPAASAAPHDAR
                     HITESVTVDSTGRLAADGTVTLSGTYRCTAAVGAVFVSSSVSQGDSSVEYGIGGTWAVC
                     DGLEHRWVNTGKSSANDLKPGAARVEATLMELRPIGGLPLPAFHAIHAQNVTLTEA"
     gene            21484..21693
                     /locus_tag="B1H29_RS08940"
                     /old_locus_tag="B1H29_08935"
     CDS             21484..21693
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973034.1"
                     /locus_tag="B1H29_RS08940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_08935"
                     /product="DUF5999 family protein"
                     /protein_id="WP_055419730.1"
                     /transl_table=11
                     /translation="MCAHRPSCPAAGSPAARVVTVHVVAAHPEQGWHLLCDGTIVFDDT
                     GELRPDGRVVAPHRVPAGRLAIAV"
     gene            complement(21712..22539)
                     /locus_tag="B1H29_RS08945"
                     /old_locus_tag="B1H29_08940"
     CDS             complement(21712..22539)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (20-252). E-value:
                     3.5e-15. Score: 48.2. Matches aSDomain:
                     nrpspksdomains_B1H29_RS08945_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973035.1"
                     /locus_tag="B1H29_RS08945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_08940"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_055419731.1"
                     /sec_met_domain="PF00561 (E-value: 2.1e-05, bitscore: 23.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDIQLTAGTVEYDDTGGDGPIVVLLHGLVHDATVWRKVLADLRT
                     DHRVIAPTLPYGAHRRPMSRPPTPDLVNELIAEFLDRLDLTDVTLVESDCGRAQTVAAR
                     HPERLARLALVACEAFDNYPPGLPGKMIGAACRVPGGVSLLVRTLGLKPLRRLPVGIGA
                     LTKRPVPDAVVDGWLRPLRTDPAIRRDFRHYGTHVRRGELLEAAEGLRGFDRPALVVWA
                     TEDLMMPRAHGRRLAELLPQGRLVEVEDTRTLIAEDQPELLASLLREFIAEKR"
     aSDomain        complement(21784..22479)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B1H29_RS08945_Abhydrolase_1.1"
                     /evalue="3.50E-15"
                     /label="B1H29_RS08945_Abhydrolase_1.1"
                     /locus_tag="B1H29_RS08945"
                     /protein_end="252"
                     /protein_start="20"
                     /score="48.2"
                     /tool="antismash"
                     /translation="PIVVLLHGLVHDATVWRKVLADLRTDHRVIAPTLPYGAHRRPMSR
                     PPTPDLVNELIAEFLDRLDLTDVTLVESDCGRAQTVAARHPERLARLALVACEAFDNYP
                     PGLPGKMIGAACRVPGGVSLLVRTLGLKPLRRLPVGIGALTKRPVPDAVVDGWLRPLRT
                     DPAIRRDFRHYGTHVRRGELLEAAEGLRGFDRPALVVWATEDLMMPRAHGRRLAELLPQ
                     GRLVEVEDTR"
     misc_feature    complement(22722..22737)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.34"
                     /tool="antismash"
ORIGIN
        1 ggcgtcaccg ccgccgcacc gctcaggccg aggctgagcc cgccaccgcc accgccgccg
       61 gacccgccga gcagcccgcc gaggccgccg cccagcccgc cgtcgtcggc ggccccggcg
      121 gagggagccg actccacggt gacaccgccc ccgacggcca tgctcaccgt catcggcacg
      181 aggcgggcca cgggggcgat cgcgccggcg cccagggcgg cgagtgccgc ccacgcggcg
      241 gccgccatca ccaggaccgc gatcgcgacg gagagggctc cctcgagggt gtggcgccac
      301 ggcgagccgg gagcagcggg gcgagacggg gcggaggaca cgggcgggct cctgtggccg
      361 ggggcaggga cggggaaacg ggatggaggc gggggcgacg gaagggggcc gccgcccccg
      421 cgggcgcggg cgccggtgcg ggccatggcg aaggcggctc agccgccgga gccccggccg
      481 ccgccgctgc ccgctgtttc gacggccggg cctggaccgg cgtcgagcga agcgccgggc
      541 gccgacgcgg tgcggccgcc gaggccgcgt tcgagccgct cgccttcgac gtccaggtcg
      601 ggcacgaacc ggtccagccg gcggggaagg cgccaggcac gccggccgag cagggcgagt
      661 accgcgggga cgatcgccat gcggacgaca aaggcgtcga agaggacggc ggcggcgagc
      721 ccgaagccga tggtcttgag catctgctcg tcggagccca tgaaggcggc gaagacggag
      781 accatgatca cggcggcggc ggtcaccacg cgtgcgctgt gctcgaagcc gctgaccacg
      841 gagtccctcg gcgactgccc gtgcacgtac gcctcgcgca tccgggtcac gaggaacacc
      901 tcgtagtcca tggcgaggcc gaagacgacg cccaccatga agatcggcgt catcgacatg
      961 accggtcccg gtaccgccac cccgaagagg gaggacagcc agccccactg gaagaccgcg
     1021 accaccgcac cgagcccggc gaggaccgag agcaggaagc ccagggccgc cttgagcggg
     1081 acgaggaggg agcggaagac ggcgatcagc agcaggaacg ccaggccgac cacgagcccc
     1141 aggtacggga gcagggcgtc ggacagtttc tgcgacacgt ccacgttcat cgccgtggat
     1201 ccggcgacca ggacgtgggc gtggctgtcg ctcacgaggg ccggctcgcg cagcgcgtgc
     1261 acgaggtcgg ccgtctcggc gctcgccggc gcggtggccg gcacgacggt gaggacggcg
     1321 gtctcccccg acctgctcag ccggggctgt ccgaccgcgg cgacgtcctc tcgagcgctg
     1381 atctctccgg cgacatcgcg ggcggcctcc tgggcgctgc cgccgccctc ggtctggacg
     1441 accatggtca gggggccgtt gtagccgggg ccgaagcctt cggcgaccag gtcgtaggcg
     1501 cggcgctgcg tggtcgaggc gggcttggac tcgtcgcccg ggagccccat ctccagggcc
     1561 gccgcgggta cggcgatcgc gccgagcagg gcggtcgcgc ccaggaggac ggtgacgggg
     1621 cgccggacga cgaagcgggc ccagcgcacg cccatggccg gcttcggccg gccggccgcg
     1681 cgccgggggc ggggacgagc ggggccgatg cggcgtccgc agaggctgag cagcgcggga
     1741 atcagggtga cggcgatgag caccgcgatg acgaccgtgc cggcggcggc gagacccatc
     1801 tgcgtcagca gcgggatgcc gaccacaccc agtcccgcga gggcgatgat cacggtcaga
     1861 ccggcgaaca cgaccgcgga ccccgcggtg cccaccgcgt gagccgccgc ctcttcccgg
     1921 cccctgccgc gggcgagttc ggcgcggtgg cgggagacga cgaacagggc gtagtcgatg
     1981 ccgacggcga ggccgatcat ggtggcgaga ccgctcgtgg tcgagccgag gccgagcggc
     2041 tccgcgagca ccttgatcgc cagaccgccg atgccgactc cgaggacggc ggtgagcagc
     2101 ggaagcccgg ctgccagcag cgagccgaag gtgatgacga gcaccacggc ggccacggcc
     2161 agcccgaggg cctcggacga atgcccaccg gccatcgcct ttacggcgtt gccgccgacc
     2221 tcgacggtca gctccggcga gcccgcctgc tcgacggtgt cctgcagcgc ctcgcgcgag
     2281 cgctcctcca gctccgaggc gggcacctcg tacgacacct gcgcgtacgc ggtggagccg
     2341 tcctcactga ccgaccgggt ggcgtacggg tcggtgaccc ggacggcctg cggcccgtcc
     2401 ccgagctccc ggaccgtctc ctggacggcc ctcctcgtct cggcgtcggt gaccttgccg
     2461 tcctcggccc ggaacaccac ccgcgccgtc gcaccgtcgg cgttcagctc cgggaagctc
     2521 cgctccagca ggtcgtacgc ctgctgtgcc tccgtgccgg gcatcgagaa gtcgttgggc
     2581 ggcggggcgg gtgctctccc cgccagcacg cccgtcccca cgagcagcac cgcccacagc
     2641 aacgcgacga gccggcgcct gcggaaggcg aaccggccca gcctggaaag gaacgtggcc
     2701 acagcaaggg ctcccagtca ggtcgaggct catcggaaca gccaccgacg ctgtcacccc
     2761 ggcctgaaag gactcggaga gttcctggga gttgcctgag agatccgctg ccacggcggg
     2821 accggagtgg cggatcccgg gcagggtcgc cgccgcggcg gcccgattca cagaaagctc
     2881 accgggtcgc accgagacgg acgccgatcc gcaggaacgc ctggacgagc ggggcgaccg
     2941 gcacgtccgg cgagatcacc tgggagccga agtggacggc gacgagatcg aggccgggtg
     3001 agacgaacaa ccgctggccg tggatgccgc tggccatgta cgagtcgtag gggtcgttca
     3061 ggacccacca caggtcgtgg tacgagagcg tggcgggcga ctcggggggg gtgcggcggg
     3121 gaaccgtacg cgacggggat aaccgtcggt cctccggccg cctgccggcc gccggcgcgc
     3181 ccgcctccag tgaatcgtca atgtcctcgc tgttcccttc gtgggcgact gcctcgcggc
     3241 cagactcacg aaagtctgtg ttggctggag tagacattga gtggcgggcc agttatggtt
     3301 tctttcgtag gcgagatcaa gaagggcccg gcagaaatga actgccgggc agcagtacgc
     3361 agttgcagtg cgcaggacgg ttcggcggtg gagttccgaa gccagggttg ttgcaggacg
     3421 gcgacgggac tgacggccgg accgggtggc ccgcagtgat caggggccgc catgagcagt
     3481 accgcagtac ccgcagtggg tattccagtg gttccccggt aaaggcgtct tactgcgggc
     3541 gcgcgtaccg ggaagttcgg cagtggggtt ctgagccaga gcagatgcag gacgggcgac
     3601 ggggctggct gccgaagagt ggcgcttctt ccaggccacc agcagtaccg cagtaccggt
     3661 tcggcaagtg attgatcaga gggaagaacg gaggagcccg cgccaccagg atcgcccgga
     3721 cgagtaatgg gtccgggtac cgcaggacat cgatagtgag gtggtctccg gtcacgcatc
     3781 cgcgatcccc gcaaccccgg cagccttcag gccgggcacg cggaaacaga aggccggcgc
     3841 attactgggg tcggcagatg gtgtagcagt tccttcgggg ccctggtgcc gtatggcacc
     3901 agggcccctc cacgcgttcc acccagaggt gcgatgacag cagacgactc gttcggccgt
     3961 ctcgacgacg actaccccgc ctacaccatg ggccgggacg ccgagatgct cggcaccacc
     4021 ccgggcttcc tgcgcgccgt cggcgaagcc cgcctcatca ccccgctgcg ctccgcaggc
     4081 ggacaccgcc gcgccgccga agtgtccaaa caacccgcag cctgaggcag tgctgcctgg
     4141 tcattgcctc agacgacagg gtgcacgggc gtgcagcgcc cgtgtcagcc gtcatggttc
     4201 ggaaggtccc ctccgcccac gtcttcggcg tgggcgtgct gctgtgctgc tgtgctgctg
     4261 tgctgctgtg ctgctgtgct gctgtgctgc tgtgctgctg gaaccaggcg accacctccg
     4321 ccttgcgcat gctgcgggag gcgtacatcg gctggatggc ttgagacatg gccgcgtccg
     4381 tagctgccgt ggctatgcgg gcggtgttgt cagtcggcgg tgagcccttc tcgcgggtgg
     4441 ggagagggcc tgtcacagac agggtcgggg tcgcgcggcc atggctgcgc gacccgaggt
     4501 gcatctgggg agggcgctac ctcggccgag agctcctgga tgccggcgtc ggctgagagc
     4561 gtcaaccgtc gccgagaccg gaagcgacga cgccgcggtc ctggtcgccg gcgtgctggt
     4621 cgtcggcgac caggatgtgg ctcggaaggg acaggagcat cgggccggct gagtagggat
     4681 acgaggccgg ggctgcgggc cgcgtggcgg ctggggcgcc gcacgcccgg tgcggctgtc
     4741 gtgccgtttg gaggggcaga cgttcagacg ctcgtccagg cttcgaggaa ggctttccgc
     4801 ccagcaggat cgtccgatct gcggtcggcg tgcaggacgc gccaggcggt gagttcgaga
     4861 tctcggagcc acagttctcc gatgacctgt gtcttgaggt cgggaagatg gtcggactcg
     4921 gcgagggctt gaccgatcac ctccccagcc gcgacgcgtt ggggcggggt catctcctcg
     4981 acagccgaga ggatttgtcg ggccagggag gttccttcgc ctgccagggc ttgcagcacc
     5041 tcggccttga ggttggcggg tagcaggtag gcggtgcccg aggacctcca caggtccgac
     5101 cagaagcgtt cgcccgcctc ggtgggggca gggagcgcgg ccagcagccc gaggagatgg
     5161 ccgatggacg cgtagccgcc ggagtgggca gccgcgacga ccgcgatacc ggcgacacgc
     5221 tccacatcga gatgccgggc ttcggggtcg gaagcgaggc ccagttggtg ttccaactgg
     5281 tttgcgagcg gggcggacac gtgggggcgg acctcaggaa gcattggcga tccttgcggg
     5341 taggcgagcg gagatgcccg ttcggaagcc ctgatcgttc cccaggatcg gcggcgctac
     5401 tcggcttggg gcggcccaat cggcgggacc tgggagccgc accggcgttc acccgtcgca
     5461 cgggtgttcc acgcgttgac cgtggcagcc ttcgccgcgc cctacatcgc catttccctg
     5521 gccacctgct gaccgccgca tcactgcacg cctgcccgcc tgccccacca gcaacccgga
     5581 tccgcggcga gaccggcgca cgggccaccg ggcggggtgc ccgccgggca ggagatattc
     5641 accgcaatac gcgttctttt gagcgctcaa cggcgaccgc cgggcctgaa cgggaccaac
     5701 cgccgcagcg cgtcgaactt cgggccgcat ggcgggcccc accccaccaa cggcttcgtg
     5761 cgagaccgca acgccggtca gtgaggcgag tatcggacgt gctcacgccc actggcccac
     5821 gtgcgggcgc ccggagcgtc cagcgagtgt catggccgac cgtccagccc tccccttcgg
     5881 gcgaaccacc ccgacatgtc gggacacccc gcacgagtcc gctcccacga cggggaacct
     5941 cagtacacat gtgaggtcgg agagggcggc gaagcccgac ggcgggatcc gcttcgcgcc
     6001 tcgacgagtg cccggagcgc ctccctggcc accgcgtcgc tctggtgcag gaacgggtcg
     6061 ttggtgcgcg gccgggggaa gtcgcccggg ctggtgacga agcgtctggg gtgcggagag
     6121 ccgtcgggac ccagagggcg ggctccgcgt gtgtcgatga ggcccgtggg ctgccgtcgg
     6181 ccggtggtcg ggtcggtctg cacctgctcc ctgatctcac gctcaccgac gaggtggagg
     6241 agcaggggat cggccacgcg cgtgagggcg cgtcccggca aacgggcctc gatcagcgcc
     6301 cgggcctgta cgacccggtc caagctgctg gtgcgcgctt cgaacacgcc gcctctgcag
     6361 gtcaccttca tgttcgcgcc gacgaagtcg acgacgcccg cgcgggcgag agccaggagc
     6421 tgttcgaggc gtggtcccgg cgggccgctg gtacggaacc ggcagaagtc gaagaaggcc
     6481 gtcatgctgt ggcttccgtt gccgggctcg acctctcccc gctggaccac ggcccacagc
     6541 gcctgcgaga tcgagaagat ggcgtgatag acggccaggt gggcgctgta ccgcggattc
     6601 cgccctctct cgaggtcgtc ggcgaggtag tgcagcatcc acgcgcgcag ggcagcggcg
     6661 tcggggaagc ggcggttcgc cagcggtctg tccaacccgt cgacgtcgat gtggtcacgg
     6721 ctgtcgggca cggcctgctc gatcaggtcc ttgaactcgg ggctccgcca ctgagcggcg
     6781 tccaaccggt cgaggaactc tccggcgtcg actccgaggc gctggggatg ggagtgcgcc
     6841 agctcccggt agccggccac ggtcagctcc cgtgcgaggg cgggccacag gtcggaggcg
     6901 aagtccaggg agtggtcggc gaagtcggct ggggagaagt agcggggtac ccgcggtggg
     6961 ggccccgaca ggacgtatgc gaacttcgag cggtacggca cacctcggcg ggaacccacg
     7021 tacagcgtgg gttcacggcc cgacggtacg tagcgcaact cgccggacgg ctcgcggcgg
     7081 aagcgcccgc cgcgtccctc ggtgaggagc accatgatgt cgatgaaggt cagcccgaat
     7141 ccgcgcatca gtacgggctc gcccgcgggg aacgcgtcca gtgagatgtc ggacgtgtac
     7201 gcggtcggct ggtagctgag gtggtgggct gccgcgtgct gggcgagccg gggttccgga
     7261 ccttgcggtt tcacctggaa gtggccctgc gccaggatca ccaggtccac gtccacggtc
     7321 tcgccgtcgt cgagtcggac gcgctggcgg ccgtcgggca gatcgcccag ggacagcacg
     7381 gacgcctggt gcgtccggac gtgggcgcgg ggcgccaccg cagcgacgct ccgccagaag
     7441 aaccaggcga ggtagtcacc cgtgagcttc cgcgtggcga accagccggc gtggacccgc
     7501 gcggcttcct cccgcgtccc cggggcgggc tggtagcccg gcggaaggtg gaggcgtccc
     7561 gcggcgagat cccgcgccca ctgttccagc gtggggcctt cgacggcggg gccttggcag
     7621 gtgaccgtgt cgtcggtgaa gagcgtgcac tcgtcggccc gggtgttcga ccagagcagc
     7681 ggtgactggc cctggcgcca cacccgtccg gcaccgactg gatacgggtc gatgacgtgg
     7741 atgtcgaaac gctcctcagg ggcgaggaga tgtgtgttcg cggcgatgcg ttcgagcacg
     7801 gacgtcccgc gtggtccgca gccgatgacc gcgatgctcg gattatccgc ccggtacggg
     7861 gccgggccgc tttcgtcggc gccgtgggcg cggtggttct cgttcatcgg tccccccttc
     7921 aggccaccag cagttggtgg gaggccaggt cgcggtagag cgtgctggac tcgatgagct
     7981 cgtggtgggt acccgtgccc accacccttc cctggtcgac gacgacgatc tggtcggcgt
     8041 cgaccacggt ggccagtcga tgagcgacga tcagcagcgt gtggtcggtg gggacggcgt
     8101 ctatcgccgc gcggaacgcc tgctcgttcc tggcgtcgag attgctggtc ggctcgtcca
     8161 gcagcaggat gggaggcgcg gcgaggagcg tacgggcaat ggccaggcgc tggcgttcac
     8221 cgccggacag caggacgccg ccttcgccca cctgcgcgtc cagtccgagc ggagaccgct
     8281 tcacgatctc gtcaaggttg acgcggcgca ggacgtctgt gagttcgtcg tcggacaggc
     8341 ccggcgcgga cagtgacagg ttctcccgga gcgttccggc gaggatcggt gcctcctgct
     8401 ccacatagcc gagccggctg cgcagttcgt cccgtgaaac ctcgcggatg tcggccccgc
     8461 tcagccgtat cgcgccggac cgtacctcgt agaagcgctc ggccaacgcc agcagagtcg
     8521 acttgccggc gcccgacggg ccgaccagtg ccgtgcgggt gccctgggag acggtgaagc
     8581 tgatgtcctc cacgaccgtc tccccctctc cgtaaccgaa cgtcacacgg tcgaagacga
     8641 gcgcggggac ggctccggcg ccgaagaccg gggtagcccc ccggctctct cgcggcggcc
     8701 cgacgcgtac gacgtcccct tccgtctcgg tcggcacgcg cagcacgtcc tctatccgct
     8761 gcagcgcacc gaggccggtc tgcaactggg agtaggcgcc gatgagctgg cccaccggca
     8821 tgatcaggaa gaacaggaac agcacgaacg ccacgaggtc accgaccgaa agcccgccgg
     8881 cggcgaccct ggcccctccc acacccagta ccagcaggaa cacgccctgc gtggcgatgt
     8941 gcgccacggg caccgtgaac gcctgcagtc gggcgagccg cagtcccatc ccgtaagcac
     9001 ggcgggcact gtgtgcgatc gcctcggtct cccgctgctc cccccgcgcg gcccggatcg
     9061 tccgtacgcc gcggatcgca cgctccagtc cggacgtcat ctctccgagc agcatctggg
     9121 cctgttcgga ggccgggcgg gtacggtgcg cgatcaccgc cgctcccgcg agaccggcga
     9181 ggaggccccc ggcggtgacc gcgaacagca gggggtcgac caggaacgcg gcgaccgccg
     9241 cgccgatgat catcagcgtc ccggtgaaga tctcgaacag ccccgaggtg acgacggacc
     9301 gcagcatcga gctgtccgat ccgatgcggg agagcagatc cccggtacgg cggctgtcgt
     9361 actcggcgac gggcagtctc agcacatgcc ccgcgagccg ctgtcgtatc cgcagtacga
     9421 cgccctcacc gacgcgccgc agcatgtagt cccggaaccc gttgatcacg gccgcgccca
     9481 ccagcaacgc gacgagcgcg acagtggatg ccgcggtcga ccgcgacgcc gagatggcgt
     9541 cgatgaccga ccgcaccagc acaggctgga ggagcgtccc gccggcggcg acgagggaga
     9601 gtaccgccgc gagggccatg gcgagcgcgt gcccacgcat gtagcgcacg aggtcacgag
     9661 tccgcacccg gccggcctgc ttcatcgtcg tccttccgag gggaagggca tggcgtccca
     9721 cctgctctct cgtacgttcc accgatggcc cggccgacca cgccgggggc ttgcagcgag
     9781 tgagcccgcc cccggcgcga ccgagtccgg tcagcagctc gtgctgaccc agctgcactt
     9841 gcagcagacc gacgtccagc tgctcgcgag gacgtcctgg ttgttcgcct cggactccat
     9901 tccctggagc cccagtacga agttcgccat ggtgttcacc tccttccccg ataggactgc
     9961 ggtggtctcg gccgtgtgcg gcaccggccg cgaggtgcgg tcagcggtgc tcggatgtgg
    10021 tgctaccggc accggccgcg gtggccgagg gctcatggtg gggaggcgtc cacggttcgg
    10081 ggccgaggaa cggcagcagt tcgctggtcc tccccgcgag tacgttgatg agctggagca
    10141 cgccggctga tcccgtaccc aggtctgtgg aggcgcggag gttctggtca ccggggaaga
    10201 tgaggccgaa ctcgtcgcac agcgcgtgga ggttgaggga tgccacgccc tcgtcgacct
    10261 gcttgtccac atccggccag tcgaggcggt gcttcacctg gtgcagcgcg ccgatcagcc
    10321 cggttctccc gttgagcagt cccgctccga tgctgaactc ggtgacacag gcgaggctca
    10381 gctccggcag ggcgccctcg atacgctcgt cgctcacatg acggaggatc aggtcaccca
    10441 ccatcgccac acccgcgctg cccgtcgcga ggtagggcag cacccgggca ccgttcttca
    10501 cctggagggt gccgtccggc atggcctcgc attcgtccag gtcccggtgc agggcggtag
    10561 cggccgctcg ccgccagcgt tcctcgccgg tcacctcgta cacccggatc atgaagagag
    10621 ccagtcccga ccagccgtac agcagtccgc cccagaagtt ctcgacggcg tttccgtttc
    10681 ggtccctgag cagtgagtcg gcggagaggg agcccgcacc cacggcgaac cggccggagt
    10741 cgacggcccc ctcgacgacg gccgcggcac ggacggcgtg gtcgaggaag cggggctccg
    10801 ccgagcgacg atagaagtcc aggctcgtca gcccgattcc ggacaggccg tcgaacaact
    10861 tcgtgccgaa cagccccgcg ctctcctccg cgaccttgtc gtagatcgcg aacgcggtgt
    10921 ccgcgcggcc catccggtgc aggacccggc agataccggc cgctccgtcg tacagcccca
    10981 gccgggggac gcggctggtg agggtgtcgt gctccagcca gtcgacgtag gggtcgagtc
    11041 cggtgactcc cgcggtgtgc agggcgtcga tcaccccggc ggcaccgaag gcgattcctc
    11101 cgccgccgtg gaagaactga ttgatgtctc ccgggaagag ccggtcttgc cggtccggtg
    11161 tggccgtacg gcggatcgac gcctggagcg cggtctcctg gaggtgccag gggccggccg
    11221 ccgtggtgaa ggccagctcc gggtcggcgg gtcgcaagcc tgactgggcc gggccgggag
    11281 ccgccaggga acggcgcagc tccgtcacca cgtcctcgtc cagctccaga cggtcccggg
    11341 ccgtgtcgat gaacgtagcc gccttggccg ggcagagcgc gaggagcgag atcagcggaa
    11401 agtacaggca caggcggatg gcgttgaacg agtagcgatc ggcctggaat ccacgtaagg
    11461 agtcgggtgc ggcgaatccg ggaacgccga gtggtcgcgg cccgtcatca ctttcccgtc
    11521 gcatggcttc gaaatcgatc aacgagatgt tcagatcttc gtcgatcatg acgttacccg
    11581 ggtgcaggtc gttgaacaca taccccctct cgtggacgtt ccgtaccgcc tgctccaact
    11641 gatccatgat gacgtccacc gagtcccggt attcccgagt ctcattccca tcgccggctc
    11701 ccgagaggaa gaggtagttc tgtgcgaccc agctctgcaa ggactggccg tagacgtgtt
    11761 ccatggccaa gaactcatgc ccgcccagcg tgtggtaatc gaagacctgc gggatgccgg
    11821 gaagtccctg cagttcggac aggaccgcgt actccctccg cagccgcgca gtcgcgtcct
    11881 cgcccgtgcg gtccagcccc gcgtagggcc tgccttcctt gaggacgacc tctgttccgt
    11941 cccgaagccg acgggcccgg tagacaccgc caccgttgga gaaatgaaga actccgagta
    12001 catcgtacgg aaattccgag ggctgctcac cggacattcg cggatggacc gattccgcga
    12061 ggaagtccgg aacctcgacc cattcgggga gcacgaagcg cggctcgcgg tggtcggcca
    12121 ccagcacccc gtcgggccgt tcgatcgcgg cgacttgggt accgtcgtcc acgtgggcga
    12181 accggagcat gaaggctccg taccggatgt acagcggccc ctcgttccag cgcaggtcgc
    12241 tgagaatgta cggccccggc cagccgccga tctcccgatc aaggtcttcc agcgttctgc
    12301 gcagctccgc ggggctcctg gtgtagaccg tgatgaactt tccgctggcc tcgcggggcg
    12361 catacttcgc acttctcgcc tgcatgacca gggagtgcgg gaggaacttg aagtggagcg
    12421 tgtagcggaa gcagtattcg gctaccttct tcaaggtttc gacggcattt tccggagtgc
    12481 tggagacatg tatcttccag ccctgcacgg gaagtttcgg tgtcccaacc ggaggctgga
    12541 ttcgggtcca ctgctcgtcg atcgagcgac gccatccgga cggcgcttcg atatggcttc
    12601 catagtccag ccaaccctca tccagagaca ctctctccgg ggtctcgtaa aatcttgggt
    12661 tggctacaca gtaagccgga taacggagat ccattggatc aacccccccg ttccgtagca
    12721 gcagattccg gattgcctcc atcggcgacg tcagcgagtc tgccaaggcg tcggggcgta
    12781 gtccttagca gagcgggact tcttcttgac ggtaagcgcc atgtacagtc atctggtcta
    12841 cgccatcatt tcgggggaag gtgtaaaaca catgcaagcc gagcgattga gtatcgatca
    12901 gctccccaca tccgagcggt tcgaccggtg ggacgacgag atcaactcga tgccctggcc
    12961 gtcccacctg gccatcgact cacccgagca cctccatacg ctgtccgaca ggctcgacct
    13021 cggcgccctc agactcttcc gattagccca gccgccggcg gcagcgatgg gcacgccgcc
    13081 ccgcggggcc gcgggcgacc cggaccagta ccacctcgtg ctccccctgc aaggcgaagt
    13141 gacgttgggg gactcgaccc gttccagggt cttcacaccc ggcgacatgt tcctggccga
    13201 cacctcccgt cgtcccgtgt tccacgccga cgtccctcgc gcccaccagc atcccgatgt
    13261 ggtgccctcg gccctggtgg ccctgcggct ccagatcccc aaggaactgg tcccgctgcc
    13321 gaccgacctg atggactccc tggtggatac acccctgcgg cagcacaacg tgttcggcct
    13381 gaccctgtcg cgcctgctcg tcgacctctt acgccatccc gccggcttct ccgccgcgca
    13441 ggggcaccgg ctctccgggg ttctgctgga actcctcacc gggatgctcg gttcgcagac
    13501 gagcgaggac gccacggcgg aggggaccaa cgacggcctg ttcgtgcgtg tccaggagtt
    13561 catccagcag cgtctggggg accccgagtt gactcccgcc caggtcgccg ccgaacacca
    13621 catctcgcgc cgtcacctgc aacgcctctt ccagcagcgc ggcatcacgg tggccgcctc
    13681 gatacggcag caacgactgg aacgcgcatg ctgcgacctc accgctccgc acctggccac
    13741 ataccccatc agcgctatcg ccgcccggtg gggttttcgt cacgcggctg acttcagccg
    13801 cgcctttcgc aaggcgtacg gggtcgcgcc gtcggacttc cggctcgcgc gtacggggag
    13861 ccgctgcggc ccgtgaggaa ccgcccctca ggcacccctg gtgcttcgcg gttctcgggt
    13921 gcgcgtcgta cgggaaccgg tgtgcgtcgt gtgactcgtt gagatgccgc cggtcagtga
    13981 ggttcccccg tggtccggga cactcgatga acctctttca tcctggcccg cgggggtgaa
    14041 tcgcctgtga acggggcctt gttggttccg gcccttccat gctcgacgtc ccgtaccggc
    14101 tcgtcgagca tgtctcccgg gtcattcaca cctgggccgt gcggatggac cggatcctca
    14161 tccagcggcg cgtggccggt cgccggccgc ccgccgggcg ccccgcgtcc gcacgagggc
    14221 cgtcgtggaa gcgctctcag acgccgtcgc ctgcgtctat cgtggggcac acggattcgc
    14281 ggcagaacag tcgtcatcca tcgaagacgc gcacagaagg agcgcccgcc gtgccggagc
    14341 agaccgtgag ggctcgtccc acgctggaag ccgtcgcggc gcgcgccggt gtctcccgtg
    14401 cgacggcctc gcgggtcgtc aacgggggcg cgggagtgcg gcccgcgctg gccgacaagg
    14461 tgcgccgggc ggtcgaggaa ctggactacg tgcccaatca cgcggcccgc accctggtca
    14521 cccggcgtaa cggtgcggtg gcggtgatca tcgcggagcc cgagttccgg gtgttcgccg
    14581 atccgttctt cgagcagcag gtacggggga tcagccggga gctgaccgcg cacgacatgc
    14641 aactggtgct gctgtgggcg gagggctccg gcgaccacga gcggatcgca cggtatctgg
    14701 ggggcgggca cgtcgacggc gcgctcgcgt tctccctcca cgacgaccgg ctgccgtccc
    14761 tgatcgcccg gaccggggtg ccggcggtgc tcggggggcg tccggccggg agcgagcacc
    14821 tgggcattcc cctcgtggac tgcgacaacc gcggcggcgc ccgggacgct gtacgccatc
    14881 tggtgcgcct gggccgcagc cgcatcgcgc acatctcggg cccgcgcgac cagacctcgg
    14941 cgatggaccg gatccacggc taccgcgatg tcctggtcga cgccgatcca cggctgctgt
    15001 gcgagggcga cttcaccgag gagggcggag cccgcgcgat gggcgagctt ctggaccggt
    15061 gccccgggat cgacgcggtc ttcgcgtcca acgacacgat ggccctgggc gcgctgcgca
    15121 cgctgcgcga gcgcggggcg cgggtgcccg aggacgtcgc ggtggtcggc ttcgacgaca
    15181 tgtcctccgt ggtcggggcc gcggagccgg cgctcaccac ggtccgccag gacatcgagg
    15241 gcatgggccg gatcatggtc aagctgctga tgcgtctgct cgacgcgccc ggcgatgagg
    15301 tgcccgcttc cgtgatcacc cggacgacac tggtccaccg ggcctcggcc tgaccgggcc
    15361 caccgctgac cggcgctcag tactgccggg cgcccgccgc tggccggcgc tcagtactga
    15421 ccggcgccca ccgctgagag gcctcccgcc cggccggccg cacctccgcg gcgcacgagg
    15481 aacggggcgg cgggcacggg gccggagccc cacgcccgcc gccgtcatcc gccggaggcc
    15541 gccgcccgcg tcactcgtag ggaatgacca cgacggacgt gtcgccgccg gtgcgcagca
    15601 gcgcgctccc gttgccgatg gcgctccaga cctccagccg caccgttccc ccgctcaggt
    15661 ttccgagggt gcctgtcgcg gccttcaggc cacgggtctg gttgtactcc tcccagcccg
    15721 tgaccgggtc ggtggcgaag tactggtagg tctcggtccg gtcgaaggtg ccgtcgccgg
    15781 tgaggtcgta gctgatgcgg gcctgctggc cgaggccgac cgcggtgccg gcgtccaccg
    15841 ggagacggaa cgtggtggac gcgcccgcct tgagggtggc gttgacaccc tcggcttcgt
    15901 agacgagcgg cttgttcggg gtgccgtcgt ggttgcggcc ctcggccgag gggatggtgt
    15961 cgctgacggc cgtgccgccg gtggccgtgg tgagggcgcc gccggagcgg agccggaagg
    16021 tgttcccggt ggaggggccg gggtcctcgc cgccgttgtc ggtgccggtc ccggtcgcgg
    16081 tggaacgcgc gggcacggtg agcttcttgc cgtcggagaa ggtgaccgtg cgggccgtgg
    16141 aaccgtggtt gtgggcggcg taggtgcggg tgccgttctt gctgaacacc gcggaggtgg
    16201 gcaggtcgcc ggtcaccgag gggtcggggg caccgagcgc gtccagggtg gtgatccagt
    16261 ggtacgtgtg cgccttggac tcgccctgct ccggggtgta tccggcgtgt cccgcgtccc
    16321 acttcgcctt ggcggaggcc gggtcggcca gcgactggaa ctcccagagg atgtcgcgcc
    16381 attccacggc gggcccgccg ttctcgcgct ccatctccgc gatgttgcgc cggatcgcgt
    16441 ccttgtgtcc ggccaggtgc ggggaaccgc ccgcggtcac gggcaggacg ttgatgccgt
    16501 ggatctcctc cggattggcg gtccaccagg tggcgtacgc cccgccgctg ccccacacca
    16561 tgccgaccgt gtcgtgggtg aacgagccgg ggaagacctg ctggtcggcg tcgaaccagt
    16621 actgggcgat cgcctcgccc tcggtggcga gcaggtagct gccgaggtcg cgcagctcgg
    16681 tgttgccggt ggccgagccc cagagcacca gcgccgcact gaggttcgtg gactccgagg
    16741 aggactcctg gttgttgccg gcggcgaagc cctggtggcc ggaggcccaa ctgtgcccgg
    16801 cgtagacgtc gaagccccgc aggaagggga aggcgccgtc ggtgcggctc gggttggcgg
    16861 tgtcgcggat cagggccttg accatgccgc cccaggcgga gtccgcggcc caggaggcgt
    16921 cgtactgggc gacgatcgcg gcggcgtaca cgtagtagcc gtagtggaag tggtggtcgt
    16981 tgagctcggc gtcgctgccg taggaggcgg ggtagccgat gagggtcttc cagtccttgt
    17041 cgtacgagaa ctcgctcgcc ccgcccgcgg tgaaccactc ctgcagccgg cccttgagca
    17101 ggccgacgag cttgtcgcgg accgcggtct caccgatctg gtcggccagt ggcaccaact
    17161 gggcgagctt gcccagcgcc ttgccggtcc agtaggtgtc cgaggccccg gagaacgggt
    17221 cggaggagtc ggcgacctcg gacaggtagc cgcgcagccg ggacgtgtcg accgcgccgg
    17281 tcttcggcag cgcgggcagc accggtgcgg ccttctgacg ggtggtgaag gaggtgccct
    17341 cccggacctt catggtgccg cggggagaga cgtaggtgta cggcgtgagg gcgtcggtgg
    17401 tgtgcagcca ctggtgccgg tagagggcct ggagggtgcc gcgttcggtg ccctccttgg
    17461 cctcggtggt gagcttgtac gtggcgccga ccgtgccgcc ggacgcgctc cagtcgacct
    17521 gcgatccggt gacgaagctg aacgcgtact tgcggaaggt cgcgagcgcg tcggtggagg
    17581 gcagtacggc gagggagaag tagtccttgc cgccgaggcc ggcgttgatc gtggtgccgg
    17641 agatgttcca gtcgctgccg gtcggcgcga acagggcgta gtggtgtccg ccgaccgtga
    17701 tgccgacgac gttgccctgg tcggagaaga cggccggcgt ggccgcggtg gtgatctggg
    17761 cgttgccgcc ggagccctgg gcgtagacga agggcatgcc gtggccgatg gtggtccgca
    17821 gggtgcggga gccgtcggac cagtacgggg tgaccgtcca gtccgaccag gcgtcggcct
    17881 tggtgtcggg cgagttgagc ccgctcaggc cgagggtgag gtcgcgcttg tgcgcgtact
    17941 cgtactggcg gccctcgccc acgacggcgg ggctggtcgg gtagccgacc tccagaccgc
    18001 cggagacggc ctggtacgtg agcgggtggc cgtacatggg cgtggagtac gggttgtcgc
    18061 cgtaacgctg gaaggcgagg gaggaccacc agtcgttggt gggtacgggt ctgcccttgg
    18121 cggcctgcgt gaccttcggg gtgaccggcg caccggtgtt ggtcgtgggg ccggtcgtgc
    18181 ccgccggccg ggtgtcggag taactcccgg ctcctacggg gacggtggcg gccgccgccg
    18241 gggacgcggc cgggccgagg cccacggccg ccagcgcggc ggccaggacc accgcggcgg
    18301 ccggccgtga tcggggagtt ggcatggggt gcacctcgtg tcgtcgagag ggacgggctc
    18361 gtcagcggcg gccgcgacaa ccgggggtgg agtgacctgg gagtggcggc ggaaccgttg
    18421 cggggagagt gggggagccc ggctgagagc gctctcaggt ggcggaaaag tatgacttct
    18481 gaaatcggat gtcaatacat cgcgcagggc agggcagttg tacagccgaa tgaggggtat
    18541 ctcgctgttt tgccctcgtc atctcttcaa gtctcgacgg gacgaacgcg gcgcgggcac
    18601 gctcccgcca tgcccgggag cgcttccctg agggcgctct cagggcagcg ctctcaccat
    18661 ctcggcatac cgtcgccgcg tgctcgggca ctacgtgccg gcggggacgg cgtcggtgta
    18721 cgcggctgct gagcgccggc cgctccaccg ccacggctcc cgcccgctca gtgaccgctc
    18781 actgtccgcg cgcctcccga ttgggcgggc gaacagatcc acgtccggga ttcggcgagg
    18841 cgctgcgcga ggccggtccg gcggcgcagg tgttctcgcc gctgattctc gggcgggcgc
    18901 tcgacagtgg cggcgtcctg gtcgcggccc tgacctgcgt cctcttcctc accggccacc
    18961 gcgccggtcc gcaccaccgg tcggacccga tggcgcatcc cccggccgac ccggcatcat
    19021 ttgacgtttt tcgtacagtt cctccgccat ccggtgtgaa ttcgggacgg ggtaagaatc
    19081 gcataaatcg ttcactcgac tgccgcgcat ccgacggagt aggcagacgt tacttcggat
    19141 atgaccgagg aatacgggga attggtgacg cttgggccgt acatctacag gcccggcagg
    19201 aatcactgtc cgtcaccgag tgacggaact ctgaccagag gcgggctccc cgtcccactc
    19261 cgggtgaccg agccggtgct ccagcgcttc ctggaggtca tgaccgaact ggagaccggc
    19321 ctcgccgcac ggtgggggcg ctctcagggg tctctgacgt gcaaccgggc ggagtgaccc
    19381 gggcgtcgtg tacgaggaac agacccacca gcatctgccc tacggcgaag gctcgttccc
    19441 ttccgcgggc ggcaccggcc gccaccgggc gcccgaggac gcctttcagc agcacctcca
    19501 ggagaccctg gtcccgccgg aacccggctg ggacccggcc gaagagctcg cgttcctcct
    19561 ccaggacgcg atggaacagc agaccggcgt cgttcccggg gcgacggaca cgtcggcgat
    19621 cgcccccgtg ccgggtacgc cgctgagcaa tctgcaggaa atcacagcgg aactgccgcc
    19681 gttgagggaa tcccccgcca gtcaccgcag ggtccgcaaa ccgaaggtga gccggctgcg
    19741 cgccgccagc ctgttcatcg cggcgctcgc cgcggtcatc gcggcctccg tgagcctgtt
    19801 cgggggcatg gtggcctacg aaccgctgcg cctggcagcc gcgacccgca cccgcgacag
    19861 cgtggtgtcc tggtggccgc tgctggtgta cgggccctgg ctggtggcgt cgctggccgt
    19921 cctgcggtcc gcgctgcacc agcgccgcgc ggtccactcc tgggccgtgg tcctgctgtt
    19981 ctccgccatc gcgatgctgc tgtgcatcgc ccaggcgccc agaacactca gcgacggtgc
    20041 ggccgcggcc ctgccggggc tggcgtcgct ggtctgcttc cagcagatcg tccgccagat
    20101 cacgctcacc cgtccacccc ggcgagcggt gccgcgccac cgccagcgcc gcccgtccgc
    20161 gccggagccc ggcgacgagg cggggagcac cgcggccccc gatccgctgt ccctgccgca
    20221 ccagcggcgg cgtcccccgc acgccccgcg gtccggcgcc ggtccccgcg ggcggtcctg
    20281 agcggggacg accgcggacg ccgctattcg gtggccccat gggcgtgccc gttgtagatg
    20341 taacgctgcg ggactccgag ggcattcgga ggaacggaat gtagtgatga ttttccggta
    20401 gccggtgaag ggaattggcg ccgtcgatcc gagcggcctc gtccgacggc ctgtggatgc
    20461 ctcggatgaa gtgcgggaag atgtggatcg acacgatgtc ggtgcctgtg cagagcgggg
    20521 cgtggcacgc catttcgccc ttcgaggtga tcgcgggtca ggacgccgtg tcgcgcccgg
    20581 tggccacgcc caccctggtc ccccgaacct cgacggcgcc ccccggaccg taaccttgct
    20641 gtcctccgtc tctggccccg agcccggaat tggagcgtct gtcccggcga cacgccgtcc
    20701 gcgcgccctt ctgccgggac aagcgctcca atcgtggctc tccaggggtc cctacaggtg
    20761 ggtcaggcct ccgtgagggt cacgttctgg gcgtggatcg cgtggaaggc ggggagcggc
    20821 aggccgccga tgggccgcag ttccatcagg gtcgcctcca cgcgggccgc gccgggcttc
    20881 aggtcgttcg cggaggactt gcccgtgttg acccagcggt gctccaggcc gtcgcagacc
    20941 gcccaggtgc cgccgatccc gtactcgacg gacgagtcgc cctggctcac ggaggagctg
    21001 acgaagacgg cgccgactgc ggcggtgcac cggtaggtgc cggagagggt gacggtgccg
    21061 tccgcggcga ggcggccggt cgagtcgacc gtcaccgact ccgtgatgtg gcgggcgtcg
    21121 tggggggcag ccgaggcggc gggggcggac agcaggagca gggcggcgcc ggcggcggct
    21181 gcggctgcgg ctttgaccgc ggctgtggct gtgactctgg tgcgggtcgc ggagcgtacg
    21241 ggcatggggg cctcccggtc ggtcggaatg ggggttccac tggtaccgga cggaggggcc
    21301 ggcggcggtg accgtcaccc cttcggtggc gagtccgcct cggccgtcgt ggaaccgtcg
    21361 ccgggttgtc cgggtgttgt cacgcttgcc gcccgggcct tggcgatgac ttcccgccgg
    21421 gcgcacggtc ggtacatgcg acggtcccga cgacgggacg gcctcccgac gtggaggtgc
    21481 gccatgtgtg cccaccggcc ttcctgcccc gcagccggct cgcccgccgc gcgggtcgtg
    21541 accgtgcacg tcgtcgccgc ccaccccgag caggggtggc acctgctgtg cgacggcacg
    21601 atcgtcttcg acgacaccgg cgagctgcgg cccgacggcc gtgtcgtcgc gccgcaccgg
    21661 gtgcccgcgg ggcgcctggc gatcgcggtc tgaccgcccg ccgggcggcg ctcagcgctt
    21721 ctcggcgatg aactcccgca gcagggaggc gagcagctcc ggctggtcct cggcgatcag
    21781 tgtccgggtg tcctcgacct ccaccagccg cccctgcggc aggagttcgg ccaggcggcg
    21841 gccgtgggcg cggggcatca tcaggtcctc ggtcgcccag acgacgagcg cgggccggtc
    21901 gaacccgcgc aacccctcgg cggcctcgag cagttcaccg cggcggacgt gcgtaccgta
    21961 gtgcctgaag tcgcgccgga tagccgggtc ggtacgcagc gggcgcagcc agccgtccac
    22021 gaccgcgtcc ggcacgggcc gcttggtgag cgcgccgatg ccgacgggca ggcggcgcag
    22081 cggtttcaac cccagggtgc ggaccagcag ggacacgccg ccgggcaccc ggcaggcggc
    22141 gccgatcatc ttgccgggca ggcccggcgg gtagttgtcg aaggcctcgc acgcgacgag
    22201 cgccagccgc gcgaggcgct cggggtgcct ggccgccacc gtctgggccc gtccgcagtc
    22261 gctttcgacc agggtgacgt cggtcaggtc caggcggtcg aggaactccg cgatcagttc
    22321 gttgaccagg tccggcgtgg gcggccggga catgggccgg cggtgggcgc cgtagggcag
    22381 ggtcggcgcg atcacccggt ggtcggtgcg caggtcggcg aggaccttgc gccagacggt
    22441 cgcgtcgtgc acgaggccgt ggaggaggac gacgatcggg ccgtcgccgc cggtgtcgtc
    22501 gtactcgacg gttcccgcgg tcagttggat gtccggcatg gcggaactct agggcgagca
    22561 cgggacgtac ggcaggaggg accgcagcgc cggcggcacg gcggcagggc ttgcggcgcg
    22621 gcagggcttg cggcgcggca gggcttgcgg cgcggcaggg cttgcggcag tgcggctatg
    22681 gcagtacggc gaatccgtcg agttccacca gggcccgttc gtcccacagg cgtacgacct
    22741 cc
//
