LOCUS       NZ_CP019724            21032 bp    DNA     linear   CON 01-JUN-2024
DEFINITION  Streptomyces pactum strain ACT12 chromosome, complete genome.
ACCESSION   NZ_CP019724
VERSION     NZ_CP019724.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces pactum
  ORGANISM  Streptomyces pactum
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8550793)
  AUTHORS   Xue,Q., Yan,X., Jia,L. and Yan,H.
  TITLE     Streptomyces pactum ACT12 Genome sequencing and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8550793)
  AUTHORS   Xue,Q., Yan,X., Jia,L. and Yan,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-FEB-2017) College of Life Sciences, Northwest A&F
            Unversity, No.22 Xinong Road, YangLing, Shaanxi 712100, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: AUG-2016
            Assembly Method                   :: SMRT v. 2.3.0
            Assembly Name :: version 2.3.0 of the PacBio Single Molecule Real
            Time
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002005225.1-RS_2024_06_01
            Annotation Date                   :: 06/01/2024 05:58:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,315
            CDSs (total)                      :: 7,221
            Genes (coding)                    :: 6,992
            CDSs (with protein)               :: 6,992
            Genes (RNA)                       :: 94
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 229
            CDSs (without protein)            :: 229
            Pseudo Genes (ambiguous residues) :: 0 of 229
            Pseudo Genes (frameshifted)       :: 84 of 229
            Pseudo Genes (incomplete)         :: 195 of 229
            Pseudo Genes (internal stop)      :: 15 of 229
            Pseudo Genes (multiple problems)  :: 62 of 229
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:20:20
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 746912
            Orig. end                         :: 767944
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP019724.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Northwest A&F Unversity.
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21032
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="7"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21032
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21032
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11032](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11032
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            318..974
                     /locus_tag="B1H29_RS03285"
                     /old_locus_tag="B1H29_03295"
     CDS             318..974
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027343.1"
                     /locus_tag="B1H29_RS03285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_03295"
                     /product="DUF4232 domain-containing protein"
                     /protein_id="WP_055421203.1"
                     /transl_table=11
                     /translation="MPNTSQPVHRTALVASAVALLGLLSACGSESSTSSAPQPTKAPRS
                     TGPDTGTVTRTATAPAVTTAPSDTAGSASASARTDGRCHTSELRAAVGRVDPGAGQRNF
                     PVVLTNTSDRTCTLYGYPGAAFVDASGSQLGPDPERAPSSPRTVTLTAGESAWAGLSFS
                     SPQISGARTATPAALLVTPPDEHDPLKVKWTAGEVPVGGHESSVSVTALEPGTGP"
     gene            complement(991..1959)
                     /locus_tag="B1H29_RS03290"
                     /old_locus_tag="B1H29_03300"
     CDS             complement(991..1959)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978092.1"
                     /locus_tag="B1H29_RS03290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_03300"
                     /product="aldo/keto reductase"
                     /protein_id="WP_055421202.1"
                     /transl_table=11
                     /translation="MQYVKLGSTGLDVSRICLGCMTYGDPGRGAHVWTLDEEASRPLIR
                     QALEAGITFFDTANVYSDGTSEEIVGKALRDFARRDDIVLATKVHGRMRPGPNGAGLSR
                     KAIVTEIDHSLRRLGTDYVDLYQIHRFDPHTPVEETMEALHDLVKAGKVRYIGASSMYA
                     WQFSKMQYTAERHGWTKFVSMQNHYNLLYREEEREMLPLCADQGVGVLPWSPLARGRLT
                     RDWDTATERSATDDFGGTLYQDGDRSVVEAVTRIAADRGLPRAQVALAWLLHQDTVAAP
                     IIGASKPGHLEDAVAAVEVTLGEKETEELELPYAPHPIAGH"
     gene            complement(2037..2588)
                     /locus_tag="B1H29_RS03295"
                     /old_locus_tag="B1H29_03305"
     CDS             complement(2037..2588)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004935608.1"
                     /locus_tag="B1H29_RS03295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_03305"
                     /product="flavoprotein"
                     /protein_id="WP_055421610.1"
                     /sec_met_domain="Flavoprotein (E-value: 2.5e-10, bitscore:
                     39.1, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEAAEAAESPGKPFLYVVVCAAGVADGVSKLITAAQERDWEVGV
                     LATPVAMGGFFDTAAVEAQTGRPIRSAWRRPEDPRPFPAPDAVVVAPATFNTVNKWAAG
                     LADTLALATLCEACGLGVPVAVLPCVGDALASHPAYRESLDRLRGMGVRFGDPYAGEAG
                     EDGGRPEFAWERALDLLEQR"
     gene            complement(2679..3113)
                     /locus_tag="B1H29_RS03300"
                     /old_locus_tag="B1H29_03310"
     CDS             complement(2679..3113)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978090.1"
                     /locus_tag="B1H29_RS03300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_03310"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_055421201.1"
                     /transl_table=11
                     /translation="MTTDRPPLPPFTRETAARKVRAAEDAWNTRDPQRVALAYSEDSVW
                     RNRDTFLEGRAAIVEFLTAKWAREHEYALRKDLWAFDGNRIAVRFQYESRDADGRWWRS
                     YGNELWEFDEHGLMTRREASINDVPIEESDRRIHGPRPVE"
     misc_feature    3140..3153
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.02"
                     /tool="antismash"
     misc_feature    3175..3188
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.02"
                     /tool="antismash"
     gene            3233..3841
                     /locus_tag="B1H29_RS03305"
                     /old_locus_tag="B1H29_03315"
     CDS             3233..3841
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978089.1"
                     /locus_tag="B1H29_RS03305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_03315"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_055421200.1"
                     /transl_table=11
                     /translation="MDSEAARERALDAAERLFYGRGVQAVGMDDVRGASGVSLKRLYQL
                     FPAKEQLVVACLERRDVRWRGRLAEHVDRYEEPGSRILAVFDWLGQWFAEPDFRGCAWI
                     NAYGELGATSAPVADRVRAHKGAFRAFLDGLAGEAGLPAAVGGQLFLLAEGAMVTAGVT
                     GGTEPARSAREAARVLLDAAGADFPAPDAAGVSAPSATR"
     gene            complement(3816..4016)
                     /locus_tag="B1H29_RS03310"
                     /old_locus_tag="B1H29_03320"
     CDS             complement(3816..4016)
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1265: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994870.1"
                     /locus_tag="B1H29_RS03310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_03320"
                     /product="ferredoxin"
                     /protein_id="WP_055421199.1"
                     /transl_table=11
                     /translation="MDIGIDKDTCIGAGQCALTAPDVFTQDDDGYSTVRPGREDGGGSA
                     LVREAARACPVGAITVSQTVR"
     gene            complement(4027..5319)
                     /locus_tag="B1H29_RS03315"
                     /old_locus_tag="B1H29_03325"
     CDS             complement(4027..5319)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004978785.1"
                     /locus_tag="B1H29_RS03315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_03325"
                     /product="cytochrome P450"
                     /protein_id="WP_234393165.1"
                     /sec_met_domain="p450 (E-value: 4.8e-26, bitscore: 90.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDTDATLKAGPTPDREPTPGRNATPDRNATPDRDATEAVAFPQD
                     RTCPYHPPAAYDPLRAARPLARITLFDGRPAWLVTGHAAARRLLADQRLSTDRTRDGFP
                     ATSARLAAVRGRKTALLGVDDPEHRNQRKMVLPDFTLKRAAALRPHIQRIVDERLDVMT
                     AQGPPADLVTDFALPVPSMVICALLGVPYADHDYFEEQSRRLLRGPRPADTQDARDRLE
                     AYLGELIDRKRHTPGEGLLDDLVRRQLGEGAVDRELLVALAVILLVAGHETTANMISLG
                     TYTLLSNPRRLTELREDPSLLPGAVEELMRVLSIADGLLRMATEDIDVDGQTIRAGDGV
                     VFSTSVINRDETVYPEPDALDWHRPARHHVAFGFGIHQCLGQNLARAELEIALHTLFER
                     LPSLRLAAPPQEIPFKPGDTIQGMLELPVSW"
     gene            5878..6327
                     /locus_tag="B1H29_RS03320"
                     /old_locus_tag="B1H29_03330"
     CDS             5878..6327
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019068527.1"
                     /locus_tag="B1H29_RS03320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_03330"
                     /product="nitroreductase family deazaflavin-dependent
                     oxidoreductase"
                     /protein_id="WP_055421197.1"
                     /transl_table=11
                     /translation="MPLEGEYEPSPTQWVREQVELYESSGGTRGTTLMDTGMPVIVLTT
                     LGARSGKLRKTPLMRVEHEGRYAVVASLGGAPKHPVWYHNVKADPRVELQDGPVKRDMT
                     AREVTGAEKAEWWERAVAAYPPYADYQKKTDRDIPVFVLEAAEES"
     gene            complement(6383..7303)
                     /locus_tag="B1H29_RS03325"
                     /old_locus_tag="B1H29_03335"
     CDS             complement(6383..7303)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008324 - monoatomic cation transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0015562 - efflux transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676630.1"
                     /locus_tag="B1H29_RS03325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_03335"
                     /product="cation diffusion facilitator family transporter"
                     /protein_id="WP_055421196.1"
                     /transl_table=11
                     /translation="MLVALAANLVIAVAKAVGGFVAGSPALLSEAAHSVADSMNEVFLL
                     AALRRSRRPADRRHPFGYGKERFFWSLLAAVGIFVMGGCFSFYQGVEALRTGAQEDLGG
                     YVAGLVVLGVALLAEGGSLLRALHQVRRQGGVATGLRDPALRTVVAEDGTAVLGVTLAM
                     TGMVLHMVTGQVVWEACASLAIGALLVFVAYRLGREARDQLIGEAADPEASGRIRSLLR
                     AQPEIDSVEALFTMKTGLDSALVAARVDLVPGLDSERVEEVAVRIKRSIARTVPEARQI
                     FLDVTDRPAREADESPAATGERGGA"
     gene            7596..8621
                     /locus_tag="B1H29_RS03330"
                     /old_locus_tag="B1H29_03340"
     CDS             7596..8621
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GST_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978084.1"
                     /locus_tag="B1H29_RS03330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_03340"
                     /product="glutathione S-transferase C-terminal
                     domain-containing protein"
                     /protein_id="WP_055421195.1"
                     /sec_met_domain="GST_C (E-value: 2.3e-06, bitscore: 26.5,
                     seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGDGGTPGNSGYGRKSFKRSRSHFADRITADGRDGWPVAPGRYR
                     LVVSRACPWASRALVSRRLLGLEDALSLAVADPVQDDRSWRFTLDPDGRDPVLGIRYLS
                     EAYDRRETGYPGGVSVPAIVDVTSGELVTNDYQQITLDLATEWTSLHRPGAPDLYPVAL
                     RDEIDEVMAGVYEDVNNGVYRAGFATGQEEYEAACAGVFRRLEQLTPRLERQRYLVGDT
                     ITEADIRLFTTLVRFDAVYHGHFKCNRWKLTENPVLWGYVRDLFQTPGFGDTVDFDHIK
                     RHYYQVHTGINPTAIVPMGPDLSGWLTPHHRQELGGRPFGEGTPPGPVPAGEAVLVRGR
                     P"
     gene            8676..8978
                     /locus_tag="B1H29_RS03335"
                     /old_locus_tag="B1H29_03345"
     CDS             8676..8978
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004979470.1"
                     /locus_tag="B1H29_RS03335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_03345"
                     /product="DUF4235 domain-containing protein"
                     /protein_id="WP_055421194.1"
                     /transl_table=11
                     /translation="MAKKKKQKLPLAYKPVGFALGWVGGTLAGLAFQKTWKVVRHEDDA
                     PDALDPDRGWGEILLAAAIQGAIFAAVRSAVDRTGAKAIERSTGVWPVGGKGGRD"
     gene            complement(9034..9426)
                     /locus_tag="B1H29_RS03340"
                     /old_locus_tag="B1H29_03350"
     CDS             complement(9034..9426)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978082.1"
                     /locus_tag="B1H29_RS03340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_03350"
                     /product="VOC family protein"
                     /protein_id="WP_055421193.1"
                     /transl_table=11
                     /translation="MALVNAGVVVLDCAEPEKLAEFYKRLLGAEESEATANRIEIRSAD
                     GFRMAFRRDVNATPPSWPRPENSLQAHLDFWVDDLDEAERGVVELGGRPVDAKDALGVH
                     EERGYSDPAGHSFTLRRTAPTAPKQG"
     misc_feature    9421..9431
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     misc_feature    complement(9850..9866)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.86"
                     /tool="antismash"
     misc_feature    9851..9865
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.16"
                     /tool="antismash"
     gene            10001..11032
                     /locus_tag="B1H29_RS03345"
                     /old_locus_tag="B1H29_03355"
     CDS             10001..11032
                     /EC_number="4.2.3.169"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0016114 - terpenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010040594.1"
                     /locus_tag="B1H29_RS03345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_03355"
                     /product="7-epi-alpha-eudesmol synthase"
                     /protein_id="WP_055421192.1"
                     /sec_met_domain="T1TS (E-value: 2e-72, bitscore: 243.6,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQDVRFDLPFDTPVSPHLSQARDRHLRWVRERGLVRSRAGFEEY
                     QSWDLAQAAARTYPHASADDMVVLMNWFSLAFLFDDQFDAGRPDRAERIAEVARELIAT
                     PLRPAGTPPRVACPITLAWSEVWDRLSDGMSLTWRSRFAASWGRFLVAHCEEVDLAAHG
                     RAGTLTLDDYTVFRRRTVGIHHSIDAGERSRGFEVPAAAMAHPLMERMRDLAADTIGFM
                     NDIHSFERERRRGDGHNLIAVLHRERGCSWQEAADEAYRMTTACLEEYVALEGRVPLMC
                     DELGLDADERSRVAMGVEAIQHWINGNYEWALTTGRYAAAKEGPVATAELAGRGSVDDL
                     LAV"
     gene            complement(11108..12355)
                     /locus_tag="B1H29_RS03350"
                     /old_locus_tag="B1H29_03360"
     CDS             complement(11108..12355)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019327716.1"
                     /locus_tag="B1H29_RS03350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_03360"
                     /product="cytochrome P450"
                     /protein_id="WP_055421191.1"
                     /transl_table=11
                     /translation="MNDDQTPSGATGGGCPVAHGPGVTRLYGPEAATDPHDIYERLRKE
                     HGSVAPVLLEGDVPAWLVLGYRENRRVLDNPLQFSRDSRIWRDFRDGRVEETSPLVPMV
                     GWRPDCVSQDGEPHRRLRGAVTDNLYAVAGRGIRRHATHFANKQIDAFADTGRADLVAD
                     FAEYLPMLVLTRVFGLAEQEGRDLAESSAQVLKGGADALTHNERIMGILGELASRKRRE
                     PGSDFTSGLIEHHSGLDEDEIVNHLRLVLITAHTMTSNLLARTLQLVLTDTAWLSGLVS
                     GQLNLSTLVEEVMWNHPPLAVLPGRFATADLELGGCPVKEGDLLVLGLAAGNHDPEVRP
                     DSAVSVQGNASHLAFSAGPHECPAQNIGQAIIETAIDVLLHRLPGLRLAVSPAELTSTA
                     STWESRLDSLPVEFAV"
     gene            complement(12352..12957)
                     /locus_tag="B1H29_RS03355"
                     /old_locus_tag="B1H29_03365"
     CDS             complement(12352..12957)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156547.1"
                     /locus_tag="B1H29_RS03355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_03365"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_055421190.1"
                     /transl_table=11
                     /translation="MDFKGFDQPGSPTAGDTRSVKVMIAGGFGTGKTTMVRSVSDIKPL
                     TTEETLTQASAGVDHLIGVADKTQTTVSLDFGKISLNDTLMLYLFGTPGQERFWFLWNG
                     LFKGALGAIVLVDTRRLASSFRAIEEMERQKVPFVIALNVFPDSRDYPVEEIRDALDIP
                     PHTPVVAFDARDRAASRDVLVTLIRHLKDRSAAALEPR"
     gene            complement(12938..13309)
                     /locus_tag="B1H29_RS03360"
                     /old_locus_tag="B1H29_03370"
     CDS             complement(12938..13309)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003995719.1"
                     /locus_tag="B1H29_RS03360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_03370"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_055421189.1"
                     /transl_table=11
                     /translation="MSAPRRPTDPSGLERYYVLTGGRSGPGGSASTLDVATLVVSRAVP
                     LPGMQHEHEEILRRCREPLSVAELGAHLHLPFNILAVLLSDLLQAGRIEARDPIPALDA
                     GRGPDLALLEEVLSGLQRL"
     misc_feature    complement(13172..13174)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13306..13716)
                     /locus_tag="B1H29_RS03365"
                     /old_locus_tag="B1H29_03375"
     CDS             complement(13306..13716)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057749.1"
                     /locus_tag="B1H29_RS03365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_03375"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_019327713.1"
                     /transl_table=11
                     /translation="MTHQGTDVSWALRDLVESIQEIRFALVASSDGKAITSYGAEDPDD
                     VDRFAAVVAGLQALAQPVAEQFPQHAGQLRLAMIEVDGGHLFVVRAGLETYLGVLAREG
                     LDQGLLGHQMRDLARRMGELLGTTPRQEEHSG"
     gene            complement(13722..15491)
                     /locus_tag="B1H29_RS03370"
                     /old_locus_tag="B1H29_03380"
     CDS             complement(13722..15491)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019327712.1"
                     /locus_tag="B1H29_RS03370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_03380"
                     /product="ATP-binding protein"
                     /protein_id="WP_055421188.1"
                     /transl_table=11
                     /translation="MELATPPPAARAPVAWYSWWLMPLGLGGGTVAATFMSSERISAAA
                     AGVVATAAGTVCVRLLLRTRAQLRRSEDAHRAAQTEHSRQWQQHVAGLERKSSAERAGL
                     EAQLTEQARTHEARLAEHGQAYEDRLAEQATTYETRLAEQNELWQERLSHQLAAVARLA
                     DEQLPDAMRRLRAGDAIDDILPTVEQCAKVGADLQAELRKVLRTALIGVEAEFDRSTSA
                     EQAVIGVGNRIHVLTSKLRGRLHEMQGEHGRLPAVARGLMELDQAIGPADCLAASIGVL
                     GGSDRPGRQWQEPQRLLSVMRGGIGRIKDFHRVQLRHLPELGVDGGLVDHLTLVFAHLL
                     DNAARYSPPTEPVIVSGKEVPNGVGIEIQDSGKGLSEEKKREAEHALAGTSPGPGLGGI
                     SEDANIGLRVVGALARRYGIRVTFADSPWLGTSVVVVVPHKYFGPLPVATGATAPEAPA
                     ATAPPAAETPAPAPAPAPAPAAVPALTADGSGAVETTPGGLPRRRSRRGEPAAGQAPAP
                     APAAPTDGTGPAERGPVSAVPPDASFAGLAAFATAGRGSGVVAGVLPPPETADVRDTTT
                     GGASTEHRTEESD"
     misc_feature    15628..15644
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.0"
                     /tool="antismash"
     misc_feature    complement(15632..15641)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.18"
                     /tool="antismash"
     gene            15739..16689
                     /locus_tag="B1H29_RS03375"
                     /old_locus_tag="B1H29_03385"
     CDS             15739..16689
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (25-313). E-value: 1.1e-58.
                     Score: 190.8. Matches aSDomain:
                     nrpspksdomains_B1H29_RS03375_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004979474.1"
                     /locus_tag="B1H29_RS03375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_03385"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_055421187.1"
                     /sec_met_domain="ADH_N (E-value: 7.6e-10, bitscore: 37.4,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 4.5e-19, bitscore:
                     67.5, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDVNTMRAISQDVLGGPEVLKEVRPQRPEPRPNEVLVRVRAAGV
                     NPTDWKHRANGGFLGEPPFVLGWDVSGVVEAVGIGVAAFRPGDEVFGMLSYPFGHGSHA
                     QYVTAPARTFTHKPAGIDHVQAGALPLVSLTAWQALVERADVQPGQRVLIHAAAGGVGH
                     VAVQIAKARGAHVIGTASAGKHAFLRSLGADEAVDYRETDFAEAVKDVDVVLDTIGGDT
                     SLRSLRVLRPGGVVVSILPVGTDEFYAEAERLGVRAVRMLVDADRADMREIAGLVESGK
                     LRATVAQTFPLADAAQAHALGETGRTTGKLVLVVD"
     aSDomain        15814..16677
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B1H29_RS03375_PKS_ER.1"
                     /evalue="1.10E-58"
                     /label="B1H29_RS03375_PKS_ER.1"
                     /locus_tag="B1H29_RS03375"
                     /protein_end="313"
                     /protein_start="25"
                     /score="190.8"
                     /tool="antismash"
                     /translation="PQRPEPRPNEVLVRVRAAGVNPTDWKHRANGGFLGEPPFVLGWDV
                     SGVVEAVGIGVAAFRPGDEVFGMLSYPFGHGSHAQYVTAPARTFTHKPAGIDHVQAGAL
                     PLVSLTAWQALVERADVQPGQRVLIHAAAGGVGHVAVQIAKARGAHVIGTASAGKHAFL
                     RSLGADEAVDYRETDFAEAVKDVDVVLDTIGGDTSLRSLRVLRPGGVVVSILPVGTDEF
                     YAEAERLGVRAVRMLVDADRADMREIAGLVESGKLRATVAQTFPLADAAQAHALGETGR
                     TTGKLVL"
     CDS_motif       16183..16245
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B1H29_RS03375_0001"
                     /evalue="1.70E-08"
                     /label="PKSI-ER_m5"
                     /locus_tag="B1H29_RS03375"
                     /protein_end="169"
                     /protein_start="148"
                     /score="26.8"
                     /tool="antismash"
                     /translation="GQRVLIHAAAGGVGHVAVQIA"
     misc_feature    complement(16709..16724)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 19.13"
                     /tool="antismash"
     gene            16813..17199
                     /locus_tag="B1H29_RS03380"
                     /old_locus_tag="B1H29_03390"
     CDS             16813..17199
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978079.1"
                     /locus_tag="B1H29_RS03380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_03390"
                     /product="anti-sigma factor antagonist"
                     /protein_id="WP_055421186.1"
                     /transl_table=11
                     /translation="MRQKSASPTRHLRVRRDRGHTVLEFRGEIDIASAAEIAPHLDRET
                     ERPDALVVLDLSGVEFFDCSGLRLLYRARHRVLDRGGRVHLVCTHPLTLRMLRITGLAQ
                     LLPPRPALEEVLGVSRPAGRRTGR"
     gene            complement(17165..18118)
                     /locus_tag="B1H29_RS03385"
                     /old_locus_tag="B1H29_03395"
     CDS             complement(17165..18118)
                     /EC_number="2.7.6.1"
                     /GO_component="GO:0002189 - ribose phosphate
                     diphosphokinase complex [Evidence IEA]"
                     /GO_function="GO:0004749 - ribose phosphate diphosphokinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978078.1"
                     /locus_tag="B1H29_RS03385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_03395"
                     /product="ribose-phosphate pyrophosphokinase"
                     /protein_id="WP_055421185.1"
                     /transl_table=11
                     /translation="MRDIAVFSGSAHPELAEEVCAHLGVPLSPTRVSRFANDCLEVQLQ
                     ANCRERDVFLVQPLVKPVQEHLVELLLMCDAARGASAGRITVVMPHYSYARSDKKDAPR
                     ISLGGRLAADLLVAAGASRVLAMTLHSPQVHGFFSVPVDHLHALRELAAHFGQYDLSRT
                     TVVSPDLGNAKEAAAFARMLGAQVAAGAKQRYADDRVSISAVIGDVAGRDVIVLDDEIA
                     KGSTVLELLDRLREAGPRTIRVACTHGLFAAGALKRLSEQPDVLEIVCTNTVPVPADDH
                     TEKLRILSIAPALAEAVRRIHNGESVSALFDAPPAG"
     gene            18312..20216
                     /gene="otr(A)"
                     /locus_tag="B1H29_RS03390"
                     /old_locus_tag="B1H29_03400"
     CDS             18312..20216
                     /codon_start=1
                     /gene="otr_A_"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190: GTP-binding protein LepA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471516.1"
                     /locus_tag="B1H29_RS03390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_03400"
                     /product="tetracycline resistance ribosomal protection
                     protein Otr(A)"
                     /protein_id="WP_055421184.1"
                     /transl_table=11
                     /translation="MHTQNTPDTPDTPNTLNIGILAHVDAGKTSLTERLLFDHGAIDRL
                     GSVDAGDTRTDDGGIERRRGITIRSAVAAFTVGDTQVNLIDTPGHSDFVAEVERALEVL
                     DGAVLLLSAVEGVQARTRVLMRTLRRLRLPTLVFVNKIDRAGARTEELLTDIRRLLTPH
                     VAPLTRVTGAGTAHARVVPRPPDERTAEALAEVDPDLLAALVDGPEPAAGDLLAALAAR
                     TADGSFHPLYHGSALGGQGVSELVEGLVRMVPAAAPATAGPTAPRGTVFAVRPGPGGER
                     TAYLRLYAGEVRPRRRLTFLRREADGRTTEVPGRVTRLDVVGGAATLTAGNIAALTVPG
                     GLRVGDRLGDLTGRAPQFAPPTLETVVRARRPEQAAPLRSALLALADQDPLLHARPAAS
                     GATALLLYGEVQMEVLAATLAEDFGVEAEFAPGRVRFLERPAGTGEAVEEMPWLERTRY
                     WATIGLRVDPGPRGSGGVFAYETELGALPRAFHQAVEETVHATLLSGLTGAEVTDYRVT
                     LIRSGFSSPVSTAADFRGLTPIVLRRALRRAGTLLYEPYHAFEAEVPPDALAAVTGRLA
                     SLGAVFTGTTGGDPVWLIAGELPARRVREAELGLPGLTRGEAVWSSRPSKDRPLGPPR"
     gene            20325..20987
                     /locus_tag="B1H29_RS03395"
                     /old_locus_tag="B1H29_03405"
     CDS             20325..20987
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389369.1"
                     /locus_tag="B1H29_RS03395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B1H29_03405"
                     /product="DUF4230 domain-containing protein"
                     /protein_id="WP_055421183.1"
                     /transl_table=11
                     /translation="MTTPISNLPRRMPGWAKVLSAIVLVLVVLFAGLRLSLVPGLKDLF
                     GTETQDRSGPALLKSVQDISRYEAASGNFQVVVDLEKDAKLLPDAIRGTRTLYVGAGTV
                     DAFVDLGRVDEADVRVDGDRTSATLRLPHAALGEPALDPERSYAVSKQRGLLDRLGDLF
                     SDNPNGEQAVQKLAARHIADAAKDSELKERAENNTTAMLRGLLHSLGFEEVRVVYGP"
ORIGIN
        1 tgctgctggt ggcccagctc acccagcgat ggggcagccg gcacacgacc gagggcaaga
       61 cgatctgggc ggagctgggg ctgctcgacg aggcgtgagc cggaggtggg cggggccggg
      121 gctgctcgac gaggagtgag ccggaggtgg gcgccgcagg agtgcgccgg ggaagtgacc
      181 cggaggactg caccccggtc cggagcgcgc ccgccgtttc cggggccgta gggcgggaca
      241 ctcgacaaca cacggcgtac ggccccgcct cgcggtgcgg accgtgcgcg agaacctgac
      301 gggagtgtgg agaagcgatg ccgaacacgt cccagcccgt acaccgcacg gccctggtcg
      361 cgagcgcggt cgcgcttctc ggtctgctga gcgcctgcgg cagcgagagc agcacgtcga
      421 gcgccccaca acccaccaag gccccgcgtt cgaccggtcc ggacacgggc accgtcaccc
      481 gcacggccac cgcgccggcg gtcaccaccg cgcccagcga caccgccgga tcagcctccg
      541 cctccgcccg caccgacggc cgctgccaca cctccgagct ccgcgccgcc gtcggccgcg
      601 tcgacccggg ggccggacag cgcaacttcc cggtcgtgct gaccaacacc tccgaccgca
      661 cctgcaccct gtacggctat ccgggcgccg ccttcgtcga cgcgtccggc agccaactgg
      721 gcccggaccc cgaacgcgcg ccctcgtcgc cgcggacggt gacgctgaca gccggcgaga
      781 gcgcgtgggc cgggctgtcg ttctccagcc ctcagatcag tggcgcccgc accgcgactc
      841 cggcggcgct gctcgtcacc ccgccggacg aacacgaccc gctcaaggtg aagtggaccg
      901 ccggtgaggt cccggtgggc ggccacgagt cgtcggtctc cgtcaccgcc ctggagcccg
      961 gaacgggccc gtgacacgcg gagccgggca tcagtgcccg gcgatcgggt ggggcgcgta
     1021 gggcagctcc agctcctcgg tctccttctc accgagcgtc acctcgaccg ctgccacggc
     1081 gtcctcgagg tgccccggct tcgacgcacc gatgatcggc gcggcgaccg tgtcctggtg
     1141 cagcagccag gcgagggcca cctgcgcccg cggcaggccg cggtcggcgg cgatgcgcgt
     1201 gacggcttcg accacggaac ggtcaccgtc ctggtagagc gtgccgccga agtcgtcggt
     1261 ggcgctgcgc tcggtggcgg tgtcccagtc ccgggtgagc cgaccgcggg cgagcgggct
     1321 ccagggcagc acgccgacgc cctggtccgc gcagaggggc agcatctcgc gctcctcctc
     1381 gcggtagagg aggttgtagt ggttctgcat cgagacgaac ttcgtccagc cgtgccgctc
     1441 ggcggtgtac tgcatcttgg agaactgcca ggcgtacatc gaactggccc cgatgtagcg
     1501 gaccttgccc gccttcacca ggtcgtgcag cgcctccatc gtctcctcga ccggcgtgtg
     1561 cgggtcgaag cggtggatct ggtagaggtc gacgtagtcg gtgcccaggc gtcgcaggct
     1621 gtggtcgatc tcggtcacga tcgccttgcg ggacagtccg gcgccgttgg gtccgggccg
     1681 catccggccg tgcaccttgg tcgcgagcac gatgtcgtcg cggcgggcga agtcgcgcag
     1741 cgccttgccg acgatctcct cgctggtgcc gtcggagtag acgttggccg tgtcgaagaa
     1801 ggtgatgccg gcctccagcg cctgccggat cagcggacgc gaggcctcct cgtcgagggt
     1861 ccacacgtgc gcgccgcggc cgggatcgcc gtaggtcatg cagcccaggc agatccgcga
     1921 cacgtccagg cccgtcgaac cgagcttcac gtactgcatc gttgctgctc ctgtcttcgg
     1981 gatcatcggt acaggggcga gcgtacgtct tcgtgcgggc tcgaaaacgg ggcgggtcag
     2041 cgctgttcga gcaggtccag cgcccgctcc caggcgaact ccggccggcc gccgtcctcg
     2101 cccgcctccc cggcgtacgg gtcgccgaag cgcacaccca tcccgcgcag ccggtccagg
     2161 ctctcccggt acgcgggatg ggacgccagc gcgtcgccca cgcacggcag gacggcgacg
     2221 ggtacgccga ggccgcacgc ctcgcacagg gtggccaggg caagggtgtc ggccaggccg
     2281 gcggcccact tgttgaccgt gttgaaggtg gccggcgcga ccacgacggc gtccggtgcc
     2341 gggaagggcc gcgggtcttc ggggcggcgc caggccgagc ggatgggacg gccggtctgc
     2401 gcctcgacgg cggccgtgtc gaagaagccg cccatggcga ccggcgtggc gaggacaccg
     2461 acctcccagt cgcgctcctg cgccgcggtg atcagcttgc tgacgccgtc ggccacgccc
     2521 gccgcacaga cgacgacgta gagaaagggc ttccccgggc tctccgccgc ttccgccgct
     2581 tccgccatgg caggcttctc cggcgtttcc gggtcgtccg gcttctccgc ggtctcggac
     2641 tgctcggcgt tccgggcctg ttcgctcacc ccagaaccct actcaacggg ccgcgggccg
     2701 tggatgcggc ggtccgattc ctcgatgggt acgtcgttga tgctcgcctc ccgccgggtc
     2761 atcaggccgt gctcgtcgaa ctcccagagt tcgttgccgt aggagcgcca ccaccggccg
     2821 tcggcgtcgc gggactcgta ctggaagcgg acggcgatgc ggttgccgtc gaaggcccac
     2881 aggtccttgc gcagcgcgta ctcgtgctcg cgcgcccact tggcggtcag gaactccacg
     2941 atggcggcac ggccctcgag gaaggtgtcg cgattgcgcc agaccgagtc ctcggagtag
     3001 gcgagcgcga cccgctgcgg atcgcgggtg ttccacgcgt cctcggcggc ccgcaccttt
     3061 cgggcggcgg tctcacgggt gaacggcggc aggggcggcc ggtcggtcgt catggctgaa
     3121 cctccgtgcg gacagatgga gaacgaccgt tctccaggtg gctgctaccg taggagaacg
     3181 accgttctca cgtcaaggaa cgcttcgagg cacacgtcgg aaagaggtcc ccatggacag
     3241 cgaggccgcc cgggagcggg cactggacgc ggcggagcgg ctcttctacg ggcggggcgt
     3301 ccaggccgtc ggcatggacg acgtccgggg cgcctccggc gtctcgctca aacgcctcta
     3361 ccagttgttc ccggccaagg agcagctcgt ggtggcctgt ctggaacggc gcgacgtgcg
     3421 ctggcgcggg cggctggcgg agcacgtcga ccggtacgag gagcccgggt cccggatcct
     3481 ggccgtcttc gactggctcg ggcagtggtt cgccgagccg gacttccgcg gctgcgcgtg
     3541 gatcaacgcg tacggcgaac tgggggccac ctccgccccg gtggcggacc gggtgcgggc
     3601 gcacaagggg gcgtttcgcg cgtttctcga cggcctggcg ggcgaggcgg gactgcccgc
     3661 cgcggtgggc gggcagctct tcctgctggc cgagggtgcc atggtgacgg cgggcgtcac
     3721 gggcggtacg gaaccggccc ggtcggcgcg tgaggcggcg cgggtgctgc tggacgccgc
     3781 cggggcggat ttcccggcgc cggacgccgc cggcgtcagc gcaccgtctg cgacacggtg
     3841 atggcgccga cggggcacgc ccgggccgcc tcccgcacca gggcgctgcc gccgccgtcc
     3901 tcccggccgg gccggaccgt gctgtagccg tcgtcgtctt gcgtgaacac gtcgggagcg
     3961 gtcagggcgc actggcccgc gccgatgcag gtgtccttgt cgatgccgat gtccatgccg
     4021 agcctcctac caggacacgg ggagttccag catcccctgg atcgtgtcgc cgggtttgaa
     4081 ggggatctcc tgaggcgggg cggccaggcg cagcgagggc agcctctcga agagggtgtg
     4141 cagggcgatc tccagttcgg cgcgggccag gttctggccg aggcactggt ggatgccgaa
     4201 cccgaaggcg acgtggtggc gggccgggcg gtgccagtcg agggcgtccg gctcggggta
     4261 gacggtctcg tcgcggttga tgacggaggt cgagaagacg accccgtcgc cggcccggat
     4321 ggtctgcccg tccacgtcga tgtcctcggt ggccatgcgc agcagcccgt ccgcgatgga
     4381 caggacgcgc atcaactcct cgaccgcgcc gggcagcagc gaggggtcct cgcgcagttc
     4441 ggtcagtcgc cgggggttgc tcaggagggt gtaggtgccc agcgagatca tgttggcggt
     4501 cgtctcgtgg cccgcgacca gcaggatgac cgccagcgcg accagcagtt cccggtcgac
     4561 cgcaccctcg cccagttgcc gccggaccag gtcgtccagc aggccctcgc cgggtgtgtg
     4621 gcgcttgcgg tcgatcaact cgcccaggta cgcctccagt cggtcgcggg cgtcctgggt
     4681 gtcggcgggg cggggaccgc gcagcagccg acgggactgt tcctcgaagt agtcatggtc
     4741 ggcgtagggg acgccgagca gcgcgcagat caccatcgag ggcacgggca gcgcgaagtc
     4801 cgtcaccaga tcggcgggcg ggccctgcgc ggtcatcacg tcgagccgtt cgtcgacgat
     4861 ccgctggatg tgcgggcgca gggcggcggc gcgtttgagg gtgaagtcgg gcagcaccat
     4921 cttgcgctgg ttgcggtgtt cggggtcgtc gacgccgagc agggcggtct ttcggccgcg
     4981 taccgccgcc aggcgcgccg acgtggcggg gaagccgtcg cgggtgcggt cggtggacag
     5041 ccgctggtcg gccagcagcc tgcgggcggc ggcgtggccg gtcaccaacc aggccggacg
     5101 gccgtcgaag agggtgatcc gggccagcgg ccgggcggcg cgcagcgggt cgtaggcggc
     5161 gggagggtgg taggggcagg tccggtcctg cgggaaggcg acggcctccg tcgcgtcccg
     5221 gtccggcgtc gcgttccggt ccggcgtcgc gttccggccg ggcgttggtt cccggtccgg
     5281 cgtcggaccc gctttcagcg ttgcgtccgt gtccggcatg gaagacctcg cagacgaaga
     5341 gtgcgtcgtg ccgatcttca ttagatgccc tgggcaccta tgtggcgacg ccaagttcgg
     5401 ccagatcggc gacggaggcg gactggccgg ggatcgccgc cgcgacggcc tgccgacgcc
     5461 tccgccctga acgcccgggc cacggcgggg ctgtccccgt acccgtggtg ccggacggcg
     5521 agaccggccc gcacggtcgg tgcagggcgg acatggctcg atagggccgc ccggcggcct
     5581 cggcggcctg ccggatctcg ccgagcacca cggtgtctcc ccgtcggccg ggacgcgctc
     5641 ggcccgggtg tccgcaccgc cgggatctcg gtgggccgcc ggcctccggt ggcgggggtc
     5701 gtcgtgcgaa cggcgacgac cgtgtcgcgg ggcgtccggc ggcgcgatga cgcgcggggc
     5761 gattgcgcgg ctgccggaag cggacgggcc ggatggggta gggatggaac ccgcaccgcc
     5821 cggtgttgca ccgcggtgtg agtccgacgc agaagacgcg acgatgggac ggatgccatg
     5881 cctcttgagg gcgagtacga acccagcccg acgcagtggg tgcgtgaaca ggtcgagctc
     5941 tacgagagct cgggcggcac gcggggcacg accctgatgg acacggggat gcccgtgatc
     6001 gtactgacca cgctgggcgc gcggagcggc aagctgcgca agacgccgct gatgcgcgtc
     6061 gagcacgaag gccgttacgc cgtggtcgcc tccctgggcg gggcgcccaa gcacccggtc
     6121 tggtaccaca acgtcaaggc ggatccccgt gtggagctcc aggacggccc ggtgaagcgg
     6181 gacatgacgg cccgtgaggt caccggcgcc gagaaggccg agtggtggga gcgtgccgtc
     6241 gcggcgtatc cgccgtacgc cgactaccag aagaagacgg accgggatat cccggtcttc
     6301 gtcctggaag cggccgaaga gagctgaacg gaagtttccc ggatccgcgt gcatggaccg
     6361 gcaccggagg ggaacacgtc gttcaggccc cgccgcgttc ccccgtcgcg gcggggcttt
     6421 cgtccgcctc ccgggcgggc cggtcggtga cgtcgaggaa gatctgtcgc gcctcgggaa
     6481 cggtacgcgc gatcgacctc ttgatgcgta ccgcgacctc ttccacccgt tcgctgtcca
     6541 ggcccggcac caggtcgacg cgcgcggcca ccagagcgga gtcgaggccc gtcttcatcg
     6601 tgaacagcgc ctcgacactg tcgatctccg gctgcgcccg cagcagcgac cggatccggc
     6661 cgctggcctc cggatcggcg gcctcgccga tgagctggtc gcgggcctcg cggcccagcc
     6721 ggtaggccac gaacacgagc agcgcgccga tcgcgagcga ggcgcatgcc tcccacacca
     6781 cctgtccggt caccatgtgc aggaccatgc cggtcatggc gagcgtcacg ccgagcaccg
     6841 cggtgccgtc ctcggcgacg accgtacgca gggccgggtc gcgcagcccg gtggcgacac
     6901 cgccctggcg ccgcacctgg tgcagggccc gcagcaggga gccgccctcg gcgagcaggg
     6961 cgacaccgag cacgaccagc ccggccacgt agccgccgag gtcctcctga gcgcccgtgc
     7021 gcagggcctc gacgccctgg tagaaggaga agcagccgcc catgacgaag atgccgacgg
     7081 ccgccaggag cgaccagaag aaccgttcct tgccgtagcc gaaggggtgc cgccggtcgg
     7141 cggggcggcg gctgcggcgc agtgcggcga ggaggaagac ctcgttcata ctgtccgcca
     7201 ccgagtgcgc ggcctccgac agcagcgcgg gcgagcccgc gacgaatccg cccaccgcct
     7261 tggcgacggc gatcaccagg ttggccgcca gggccaccag cacggtgaca cgtgtcctgc
     7321 ggtcggcctt cccgcctgcc tcgcgatcgg cctcgcgtgc ggcgccgcct tcagtaccgc
     7381 ccgcaacgcc gcccgcaatg ccgccttcgg tgtcgtgttc gctgtcgggg ccggtcttca
     7441 ggcccggctt ctcttcctgg tctgtcccac tcacgagggg ccgaatgccc ccggccggcg
     7501 tggctcacac ctccttgtgg gtggcccacc agtgccgacg gccgaaaacg gggaacgcgt
     7561 ccaccagggc acacgaacga ctgggaggca ggtccatgag cggtgacggc gggacgcccg
     7621 gcaacagcgg ctacggcagg aagtccttca agcggtccag gagccacttc gcggaccgga
     7681 tcaccgcgga cggccgggac ggctggccgg tggcgcccgg ccggtaccgg ctggtggtga
     7741 gccgtgcctg cccgtgggca agccgcgccc tggtctcgcg gcggctgctc ggtctggagg
     7801 acgccctgtc cctcgcggtc gccgatcccg tccaggacga ccgaagctgg cgcttcaccc
     7861 tggatccgga cggccgcgac ccggtcctcg gcatccgcta cctcagcgag gcgtacgacc
     7921 ggcgggagac cggctatccg ggcggggtca gcgtgcccgc gatcgtggac gtaaccagcg
     7981 gagagctggt caccaacgac taccagcaga tcaccctgga cctggcgacc gagtggacgt
     8041 ccctgcaccg gccgggcgcg cccgacctgt atcccgtcgc gctgcgcgac gagatcgacg
     8101 aggtgatggc aggcgtctac gaggacgtca acaacggtgt gtaccgggcg ggcttcgcga
     8161 ccggccagga ggagtacgag gccgcgtgcg cgggtgtctt ccggcgtctg gagcaactga
     8221 caccccggct ggagcggcag cgctacctgg tcggcgacac gatcaccgag gcggacatcc
     8281 ggctgttcac gacactggtc cgcttcgacg ccgtctacca cggccacttc aagtgcaacc
     8341 gctggaagct gacggagaac ccggtgctgt gggggtacgt ccgcgacctg ttccagacgc
     8401 ccggcttcgg cgacaccgtc gacttcgacc acatcaaacg ccactactac caggtgcaca
     8461 ccggcatcaa cccgaccgcc atcgtgccca tgggcccgga cctgtccggc tggctcacgc
     8521 cccaccaccg gcaggaactg ggcggccggc cgttcggcga gggcacaccg ccggggccgg
     8581 tccccgccgg cgaggcggtt ttggtgcggg gcaggccctg accccacgac cggccccgcc
     8641 gcccatccga tcaccgcaca cacaaggagt cccacgtggc caagaagaag aagcagaagc
     8701 tccccctcgc ctacaagccc gtcggcttcg cgctgggctg ggtgggcggc acgctggcag
     8761 ggctggcgtt ccagaagaca tggaaggtgg tccggcacga ggacgacgcg cccgacgcgc
     8821 tggacccgga ccgcggctgg ggggagatcc tgctcgccgc cgcgatccag ggcgccatct
     8881 tcgccgcggt gcgcagtgcc gtggaccgga ccggcgccaa ggccatcgaa cgctcgaccg
     8941 gtgtctggcc ggtcggcggg aagggcggac gcgactgacc gcaccggcgg caccgcccct
     9001 cccccgtcac cgacggcacc cggcaggcgc tcgctagccc tgcttgggtg ccgtcggcgc
     9061 ggtacgccgc agggtgaagg agtggcccgc cgggtcggag tagccacgct cctcgtgcac
     9121 cccgagtgcg tccttcgcgt ccacggggcg cccaccgagt tcgacgacgc cgcgttccgc
     9181 ctcgtccagg tcatccaccc agaagtccag atgtgcctgg agggagtttt cgggccgggg
     9241 ccagctcggc ggggtggcgt tgacgtcccg tcggaacgcc atacggaagc cgtccgccga
     9301 cctgatctcg atccggttgg cggtcgcctc gctctcttcc gctcccagca gcctcttgta
     9361 gaactcggcg agcttctcgg gctcggcgca gtcgagcacc acgacgcccg cgttgaccag
     9421 tgccatgtct cctccgaagg attcggggtg cggggcggtc gtgccccgcg ccctgtacct
     9481 tgcggatatc ccggcccggc cggttcactc ggtcggcagc caccgtccgt cgcgcatcgg
     9541 ctcgcgccct gcgagcccgt cggcctcgca ccacgcctgg atccgctgcg gatggacccg
     9601 gaagcacagg tggggcgtgg cgagggcgcc cgggtcgaag cccgataccg acgcggaccc
     9661 gggtcccctg actccctgcg tatcagacaa ggtagccggc ggcacgactg ctccgaggag
     9721 tgcggtgacc gcgatccacc cggtccggtc gcggcggcca cgcggacgac actgacgtcc
     9781 gcggcggggg ccggcgagtg tacgcggctc atgagacatg ggcagttacc aagatcacga
     9841 acgggcgccg tgtagatcat ttacagtcgg ggcagcctcg tactgcttct cggttcaact
     9901 ttcgtatcgg gaagcccagt tcgagtgcgc gggtggcccg gcgggcgccc gctcgcaggg
     9961 cacgggggga ctccgcgttc cgtctcccga aaggatgcac atgcctcagg acgtccggtt
    10021 cgacctcccc ttcgacactc ccgtcagccc gcatctcagc caggcacgtg accgtcatct
    10081 gcgatgggtg cgcgagcggg ggctggtgcg cagccgggcc gggttcgagg agtaccagtc
    10141 gtgggacctc gctcaggccg cggcccgcac gtacccccac gcgtcggcgg acgacatggt
    10201 cgtcctgatg aactggttct ccctcgcctt cctcttcgac gaccagttcg acgccggccg
    10261 gccggaccgc gcggagcgca tagcggaggt ggcgcgggaa ctcatcgcca caccgctgcg
    10321 tccggcgggt accccgccac gggtggcatg ccccatcacc ctggcctggt cagaggtttg
    10381 ggaccggctc tcggatggca tgtccctgac ctggaggtcg cggttcgccg cctcctgggg
    10441 gcgtttcctg gtggcgcact gcgaggaggt cgacctggcg gcccacggcc gggccgggac
    10501 gctcacgctg gacgactaca ccgtcttccg gcgccgtacg gtcggcatcc accacagcat
    10561 cgacgcgggc gagcgcagcc gcgggttcga ggtgccggcc gcggcgatgg cgcatccgct
    10621 gatggagcgg atgcgggacc tggccgcgga caccatcggg ttcatgaacg acatccactc
    10681 cttcgagcgc gaacgccgcc gcggggacgg ccacaacctc atcgccgtgc tgcaccggga
    10741 acgcggctgc tcctggcagg aggccgccga cgaggcgtac cgcatgacga ccgcctgtct
    10801 cgaggagtac gtcgccctcg agggccgcgt gccgctgatg tgcgacgagc tggggctgga
    10861 cgccgacgag cggtcccggg tggcgatggg cgtcgaggcg atccagcact ggatcaacgg
    10921 caactacgag tgggcgctga ccaccggccg gtacgcggcg gccaaggagg gcccggtcgc
    10981 cacggccgaa ctggccgggc ggggttcggt ggacgacctg ctggccgtgt gagacgggcg
    11041 cgccgcccgg ccggacgctc ccggccgggc gggcggcgcc gtgcgacgcg gtccgcgccg
    11101 gcggacgcta tacggcgaac tcgaccggca ggctgtccag ccgtgactcc caggtggagg
    11161 ccgtggaggt gagttcggcc ggggaaaccg ccaggcggag gcccggcaga cggtgcagca
    11221 gcacgtcgat ggccgtctcg atgatggcct ggccgatgtt ctgcgccggg cactcgtggg
    11281 ggccggcgct gaaggcgagg tgcgaggcgt tgccctggac cgacacggcg ctgtcggggc
    11341 ggacctcggg gtcgtggttg cctgccgcga ggcccaggac gagcaggtcg ccctccttga
    11401 ccgggcagcc gccgagttcc aggtcggcgg tggcgaaccg gcccggcagc accgcgagcg
    11461 gcgggtggtt ccacatcacc tcctccacca gcgtggacag gttgagctgc ccgctcacca
    11521 ggccggagag ccacgcggtg tcggtgagga cgagctggag cgtccgggcc agcaggttgc
    11581 tggtcatggt gtgggcggtg atcagcacca ggcgcagatg gttgacgatc tcgtcctcgt
    11641 cgagaccgga gtggtgttcg atgagcccgg aggtgaagtc ggacccgggt tcccgccgct
    11701 tgcgcgacgc gagttcgccg aggatgccca tgatgcgctc gttgtgggtg agggcgtccg
    11761 caccgccctt gagcacctgt gcgctggact cggcgaggtc gcgcccctcc tgctcggcga
    11821 ggccgaagac gcgggtgagg accagcatgg gcaggtactc ggcgaagtcg gccacgaggt
    11881 cggcgcggcc ggtgtcggcg aaggcgtcga tctgcttgtt ggcgaagtgc gtggcgtgcc
    11941 tgcggatccc gcgcccggcc acggcgtaca ggttgtcggt gaccgccccg cgcagccggc
    12001 ggtgcggttc gccgtcctgg gagacgcagt cgggacgcca gcccaccatg gggaccagcg
    12061 gggacgtctc ctcgacccgg ccgtcccgga agtcccgcca gatccgcgag tcgcggctga
    12121 actgcagggg gttgtccagc acccgccggt tctcccggta cccgagcacc agccacgcgg
    12181 ggacgtctcc ctccagcagc accggcgcga cggagccgtg ctccttgcgg agccgctcgt
    12241 agatgtcgtg cgggtcggtc gccgcctcgg gcccgtagag ccgggtgaca cccgggccgt
    12301 gcgcgacggg gcagccgccg ccggtggcgc cggacggggt ctggtcgtcg ttcatcgtgg
    12361 ctccagggcg gcggccgagc ggtccttcag gtgccgtatc agggtgacga gcacgtcgcg
    12421 gctggcggcg cggtcgcggg cgtcgaaggc gacgaccggc gtgtgcgggg ggatgtcgag
    12481 ggcgtcccgg atctcctcga cggggtagtc ccgggagtcg gggaagacgt tgagcgcgat
    12541 gacgaagggg accttctgcc gttccatctc ctcgatcgcc cggaaactgg aggccagccg
    12601 cctcgtgtcc accaggacga tcgcgccgag cgcacccttg aacaggccgt tccacaggaa
    12661 ccagaacctc tcctggccag gggtgccgaa caggtacagc atcagcgtgt cgttgaggct
    12721 gatcttgccg aagtccaggc tcacggtggt ctgcgtcttg tcggcgacac cgatgaggtg
    12781 gtcgacgccg gcgctggcct gggtgagggt ctcctcggtg gtcagcggct tgatgtcgct
    12841 gacggagcgg accatggtgg tcttgcccgt gccgaatccg ccggcgatca tcaccttcac
    12901 cgagcgggtg tccccggccg tcggtgaccc cggttggtca aagcctttga agtccactga
    12961 gtacctcctc aaggagcgcg aggtcgggcc cgcggccggc gtcgagtgcc gggatgggat
    13021 cacgggcttc gatgcggcct gcctggagca ggtcggacag cagcaccgcg agaatgttga
    13081 agggcaggtg gaggtgggcg ccgagttcgg ccaccgacag cggttcacgg caacgccgga
    13141 ggatctcctc gtgctcgtgc tgcatgcccg gtaagggaac ggcgcgggag acgacgaggg
    13201 tcgccacgtc gagggtcgac gccgaaccgc ccggcccgct gcgccctccg gtgaggacgt
    13261 agtagcgctc gagaccggac ggatcggtcg gtcggcgggg agcactcatc cagagtgctc
    13321 ctcctggcgc ggagtggtgc cgaggagttc acccatcctg cgggccaggt cgcgcatctg
    13381 atggccgagc aggccctggt cgaggccttc gcgggcgagg acgccgagat acgtctccag
    13441 gcccgcgcgg acgacgaaga ggtgcccgcc gtccacttcg atcatcgcga gccgcaactg
    13501 tcccgcgtgc tgcgggaact gttcggcgac cggctgggcc agcgcctgca gtccggccac
    13561 cacggcggcg aaacggtcca cgtcgtcggg gtcttcggcc ccgtaggagg tgatcgcctt
    13621 gccgtcgctg gaggccacga gggcgaagcg gatctcctgg atgctctcca caaggtcgcg
    13681 gagcgcccag ctcacgtcgg ttccctggtg cgtcatgggg actagtcgct ctcttcagtg
    13741 cggtgctcgg tggacgcgcc accggtggtc gtgtcacgga cgtcggcggt ctccggtggc
    13801 ggcaggacgc cggccaccac gccggatccg cgtccggcgg tggcgaacgc ggcgaggccg
    13861 gcgaaggagg cgtccggcgg aacggcggaa acggggcccc gttcggccgg accggtcccg
    13921 tcggtgggtg cggcgggcgc gggggccggg gcctgtccgg cggccggctc gccgcgcctg
    13981 ctccggcggc ggggcagtcc gcccggggtg gtctccacgg cgccggagcc gtcggcggtg
    14041 agggccggaa cggcggcggg cgcgggtgcc ggtgccggtg ccggtgcggg agtctcggcg
    14101 gcgggtggtg ccgtggcggc cggcgcctcc ggcgcggtgg cgccggtggc caccggcagc
    14161 ggaccgaagt acttgtgcgg cacaacgact acgacagagg tacccagcca tggcgagtcg
    14221 gcgaaggtca cccggatgcc gtaacggcgg gcgagggcgc cgacgacgcg gagaccgatg
    14281 ttggcgtcct ccgagatgcc gccgaggccg gggccgggcg aggtgcccgc gagggcgtgc
    14341 tcggcctcgc gcttcttctc ctcgctcagg cccttgccgg agtcctggat ctcgatgccg
    14401 acaccgttgg ggacctcctt gccggagacg atcaccggct cggtgggcgg tgagtagcgc
    14461 gcggcgttgt ccagcaggtg ggcgaagacc agcgtgaggt ggtccaccag gccgccgtcg
    14521 acacccagct cgggcagatg gcgcagttgg acgcggtgga agtccttgat ccggccgatg
    14581 ccgccgcgca tcacgctcag caggcgctgc ggctcctgcc actgccgtcc cgggcggtcg
    14641 gagccgccga gcacaccgat gctggcggcg aggcagtcgg cgggaccgat ggcctggtcg
    14701 agttccatca ggccccgggc gacggccggc agccgcccgt gctcaccctg catctcgtgc
    14761 agccgaccac ggagtttgct ggtcaggacg tggatgcggt tacccacgcc gatgacggcc
    14821 tgttcggcgg aggtcgaccg gtcgaactca gcctccacgc cgatcagcgc ggtcctgagc
    14881 accttgcgca gttcggcctg gaggtcggca ccgaccttgg cgcactgctc gacggtcggc
    14941 aggatgtcgt cgatggcgtc cccggcgcgc agcctgcgca tcgcgtcggg cagttgctcg
    15001 tcggcgagcc gggcgaccgc ggcgagctgg tggctcaacc gctcctgcca gagctcgttc
    15061 tgttcggcga ggcgggtctc gtacgtggtg gcctgctcgg ccagccggtc ctcgtaggcc
    15121 tggccgtgtt cggccagccg cgcctcgtgt gtccgcgcct gctcggtgag ctgtgcctcc
    15181 agcccggcgc gttcggccga ggacttgcgc tccaggccgg ccacgtgctg ctgccactgc
    15241 cgggagtgct cggtctgcgc ggcgcggtgg gcgtcctcgc tccggcgcag ttgcgcccgg
    15301 gtgcgcagga ggaggcgtac gcacacggta ccggcggccg tcgcgacgac accggcggcg
    15361 gccgcggata ttcgttccga gctcatgaac gtggcggcta ccgtcccgcc tcccaggccc
    15421 agtggcatca gccaccagct ataccaggcg acaggggccc gcgccgccgg tggcggagtg
    15481 gcgagttcca tctgcatcct tcgaaagcaa aacgatcgaa cggggggggt gggcgtgcaa
    15541 ggggaccgca ctcatgagtc cgcaacgcga gccgacccgt cggatcgtgt caactcgcag
    15601 cgccgacagg gagcttatcg gttgggatgg ttaaaagatc aattccacgg ccctgcggaa
    15661 gtgaggattc cgtcacggtc cgccaggagg agaccgcgct gtttcgccga cgggcggagc
    15721 aaggcaagct gggtgaccat gagcgacgtg aacaccatgc gagccatcag ccaggacgtc
    15781 ctcggcggtc ccgaggtcct gaaggaagta cggccacagc gtcccgagcc gcgcccgaac
    15841 gaggtgctgg tccgggtgcg tgccgccggc gtgaatccga ccgactggaa gcaccgggcg
    15901 aacggcggtt tcctcggcga gccgccgttc gtgctgggct gggacgtctc gggcgtggtg
    15961 gaggcggtgg ggatcggcgt cgccgccttc cggcccggcg acgaggtgtt cggcatgctg
    16021 tcgtacccgt tcggccacgg ctcccacgcg cagtacgtca ccgctcccgc gcgcaccttc
    16081 acccacaagc cggccggaat cgaccacgtc caggcgggcg cgctccccct ggtctcactg
    16141 acggcgtggc aggcactggt ggagcgggcg gacgtccagc cgggacagcg ggtgctgatc
    16201 cacgcggcgg ccggcggtgt cggccatgtg gcggtgcaga tcgccaaggc ccggggcgcc
    16261 cacgtgatcg gcaccgccag cgcgggcaag cacgcgttcc tgcgctccct cggggcggac
    16321 gaggcggtgg actaccggga gacggacttc gccgaggccg tgaaggacgt cgacgtggtc
    16381 ctggacacga tcggcggcga cacgtccctg cgctcgctgc gtgtgctgcg gccgggcggg
    16441 gtggtggtgt cgatcctgcc ggtgggcacg gacgagttct acgcggaggc cgaacggctg
    16501 ggcgtgcgcg cggtgcggat gctcgtggac gcggaccggg cggacatgcg ggagatcgcc
    16561 ggcctggtcg agtcggggaa gctgcgggcc acggtcgcgc agacgttccc gctggccgac
    16621 gcggcacagg cacacgcgct cggcgagacc ggccgcacca cgggcaagct ggtcctcgtc
    16681 gtcgactgac cgccgggtgt gagatttcga tgacatatgt caatcgaaca tgctcaaact
    16741 cgctcgatcg gggtaacttt ccgagcagag taggtagttg agcccccgga acaggctgga
    16801 ggcacggtcg tcgtgcggca gaaatccgcg tcgcccaccc ggcatctgcg cgttcgccgc
    16861 gaccgggggc acacggtgct ggagttccgg ggcgagatcg acatcgcgtc ggccgcggag
    16921 atcgccccgc acctggaccg ggagacggag cgccccgacg ccctggtcgt gctcgacctg
    16981 agcggggtcg agttcttcga ctgctccgga ctgcggctgc tgtaccgggc gcggcaccgg
    17041 gtgctcgacc ggggcgggcg ggtgcacctg gtgtgcaccc acccgctgac cctgcgcatg
    17101 ctgcggatca ccggcctggc acaactactg ccgccgcggc cggccctgga ggaggtcctc
    17161 ggcgtcagcc ggccggcggg gcgtcgaaca gggcgctgac cgactccccg ttgtggatgc
    17221 gccgcacggc ctcggcgagc gcgggagcga tggacaggat ccgcagcttc tccgtgtggt
    17281 cgtcggccgg caccggcacg gtgttggtgc acacgatctc cagcacgtcc ggctgctcgc
    17341 tgagccgctt gagcgccccg gccgcgaaca gcccgtgcgt acaggcgacc cggatcgtgc
    17401 gcggccccgc ctcccgcagc cggtcgagga gttcgaggac ggtgctgccc ttggcgatct
    17461 cgtcgtcgag cacgatgacg tcgcgcccgg cgacatcccc gatcacggcg ctgatgctga
    17521 cccggtcgtc ggcgtaccgc tgcttggcgc cggccgcgac ctgggcgccg agcatccgcg
    17581 cgaacgcggc ggcctccttg gcgttgccca ggtccggcga gacgaccgtg gtgcgggaca
    17641 ggtcgtactg accgaagtgc gcggccagtt cacgcagggc gtgcaggtgg tcgaccggga
    17701 ccgagaagaa cccgtgcacc tgcggcgagt gcagggtcat ggcgagcacc cggctcgcgc
    17761 ccgccgccac cagcaggtcg gccgccaggc gcccgcccag cgagatgcgg ggcgcgtcct
    17821 tcttgtcgga gcgggcgtag gagtagtggg gcatgacgac ggtgatacgg ccggccgacg
    17881 ccccgcgggc cgcgtcgcac atcagcaaca gctcgacgag atgttcctgg accggcttga
    17941 ccagcggctg gaccagaaag acatcccgtt ctcggcagtt ggcctggagc tgtacctcca
    18001 ggcagtcgtt ggcgaaccgg ctgacccggg tggggctcag cgggacgccc agatgtgcgc
    18061 agacctcctc ggccagctcg ggatgggcac taccgctgaa cacggcgatg tctcgcacgg
    18121 accgctccta gcatgatcct taccggccgg gggacctcag cttacggata tccggttgcg
    18181 gcgggcccgg cgggtggggc catgatggcg ccgtccgtgt ttcctcaggt caggaccccc
    18241 tcgcatgcgc cgactcctcg acatcgccca gcgccccttc cggctcacgg tcatcgagga
    18301 ctcgaccccg catgcacact cagaacaccc cggacacccc ggacactccg aacaccctga
    18361 acatcggcat cctggcccac gtcgacgccg gtaagaccag cctcaccgaa cggctcctgt
    18421 tcgaccacgg cgccatcgac cggctcggca gcgtcgacgc cggcgacacc cgtacggacg
    18481 acggcgggat cgaacgccgc cgcggcatca ccatccgctc cgccgtcgcc gccttcaccg
    18541 tcggcgacac ccaggtcaac ctgatcgaca ccccgggaca ctccgacttc gtcgccgagg
    18601 tcgagcgcgc cctggaggtc ctcgacggcg cggtgctgct gctgtccgca gtggagggcg
    18661 tacaggcgcg gacccgcgtg ctgatgcgca ccctgcggcg gctgcggctg cccaccctgg
    18721 tgttcgtcaa caagatcgac cgggccggcg cgcgcaccga ggagctgctc accgacatcc
    18781 gccggctgct gacgccgcac gtcgcgccgc tgacccgggt gacgggcgcc ggcaccgcgc
    18841 acgcccgcgt cgtaccccgc ccgccggacg agcggaccgc cgaggcgctc gccgaggtcg
    18901 acccggacct cctggcggcg ctggtggacg gccccgagcc ggccgccggg gacctcctcg
    18961 ccgcgctcgc cgcccgcacc gccgacggct cgttccaccc gctgtaccac ggctccgcac
    19021 tcggcggcca gggtgtctcg gagctggtcg agggtctggt ccggatggtc ccggccgccg
    19081 cacccgccac ggcgggcccc acggcaccgc gcggcacggt cttcgcggtg cgccccggac
    19141 ccggcggcga gcggacggcg tacctgcgct tgtacgccgg tgaggtccgc ccgcgccggc
    19201 ggctgacgtt cctgcggcgc gaggccgacg ggcggaccac cgaggtcccc ggccgggtga
    19261 cgcgtctgga cgtggtcggt ggggcggcga cgctcaccgc ggggaacatc gccgcgctca
    19321 ccgttcccgg cggcctgcgc gtcggcgacc ggctcggcga ccttaccggc cgcgccccgc
    19381 agttcgcacc gccgaccctc gagaccgtgg tgcgggcccg gcgtcccgaa caggcggcgc
    19441 cgctgcgctc cgccctgctg gcgctggccg accaggaccc gctgctgcac gcccgcccgg
    19501 cggcgtcggg cgccaccgcg ctgctcctgt acggcgaggt ccagatggag gtgctcgcgg
    19561 cgacgctggc ggaggacttc ggcgtcgagg cggagttcgc gccgggccgg gtccggttcc
    19621 tggagcgccc ggccggcacc ggcgaggccg tggaggagat gccgtggctc gagcgcaccc
    19681 ggtactgggc gacgatcggg ctgcgcgtcg accccgggcc gcgcggttcg ggcggggtgt
    19741 tcgcctacga gacggaactc ggcgcgctcc cccgcgcctt ccaccaggcc gtcgaggaga
    19801 cggtgcacgc caccctgctg agcggcctga ccggcgccga ggtcacggac taccgggtga
    19861 cgctgatccg ttccggcttc agctccccgg tgagcaccgc cgccgacttc cgcgggctga
    19921 ccccgatcgt gctgcgccgg gccctgcggc gggcggggac gctgctgtac gagccgtacc
    19981 acgccttcga ggcggaggtc ccgccggacg cgctcgccgc cgtgacgggc cggctcgcct
    20041 cgctgggcgc ggtcttcacc ggtacgacgg gcggcgaccc ggtctggctg atcgcgggcg
    20101 agctgccggc ccggcgggtg cgggaggccg agctggggct gcccggcctc acccgcgggg
    20161 aggccgtgtg gtcgtcccgg ccttcgaagg accgtccgct cgggccgccg cgctgaaccg
    20221 tcgcacgccc ccttcgcgct ccctcacccg ccaccttccg tcaaccgccc tgcctggccc
    20281 gggagatgga gggcatcagg acagtagaaa ggagggccga cgccatgacg actccgatca
    20341 gcaacctccc gcggcgcatg cccggctggg caaaggtgct gagcgccatc gtgctcgtcc
    20401 tcgtcgtgct gttcgcgggg ctccggctga gcctcgtacc ggggctgaag gacctcttcg
    20461 gcaccgagac ccaggaccgc tcgggccccg cgctgctgaa gtccgtccag gacatcagcc
    20521 gctacgaagc cgcctccggc aacttccagg tcgtcgtgga cctggagaag gacgccaagc
    20581 tcctgccgga cgcgatccgc ggcacccgca ccctgtacgt cggggcgggc accgtcgacg
    20641 ccttcgtgga cctcggccgg gtggacgagg ccgacgtgcg ggtcgacggc gaccgcacgt
    20701 cggccacgct ccggctgccg cacgcggcac tcggcgagcc ggccctcgac cccgagcgct
    20761 cctacgcggt gtccaagcag cgggggctcc tcgaccgcct cggcgacctg ttctcggaca
    20821 acccgaacgg cgagcaggcc gtgcagaagc tcgcggcccg gcacatcgcc gacgcggcga
    20881 aggacagcga gctgaaggag cgtgccgaga acaacacgac ggcgatgctc cgggggctgc
    20941 tgcactccct cggcttcgag gaggtgcggg tggtctacgg gccctgaacg gctacccggc
    21001 atcctcgacg gcttcacggg taaccgccct ag
//
