LOCUS       NZ_MCOK01000001        22318 bp    DNA     linear   CON 22-OCT-2024
DEFINITION  Nocardiopsis sinuspersici strain UTMC 00102 NOSIN_1, whole genome
            shotgun sequence.
ACCESSION   NZ_MCOK01000001
VERSION     NZ_MCOK01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Nocardiopsis sinuspersici
  ORGANISM  Nocardiopsis sinuspersici
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsidaceae; Nocardiopsis.
REFERENCE   1  (bases 1 to 6071583)
  AUTHORS   Tokovenko,B. and Kalinowski,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-AUG-2016) Helmholtz Institute for Pharmaceutical
            Research Saarland, Helmholtz Centre for Infection Research, Campus
            C2.3, Saarbrucken 66123, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 20-JUL-2016
            Assembly Method                   :: SPAdes v. 3.8.1
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 106.0x
            Sequencing Technology :: Illumina NextSeq; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001998325.1-RS_2024_10_22
            Annotation Date                   :: 10/22/2024 13:01:47
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,351
            CDSs (total)                      :: 5,274
            Genes (coding)                    :: 5,224
            CDSs (with protein)               :: 5,224
            Genes (RNA)                       :: 77
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 50
            CDSs (without protein)            :: 50
            Pseudo Genes (ambiguous residues) :: 0 of 50
            Pseudo Genes (frameshifted)       :: 13 of 50
            Pseudo Genes (incomplete)         :: 44 of 50
            Pseudo Genes (internal stop)      :: 2 of 50
            Pseudo Genes (multiple problems)  :: 7 of 50
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 18:06:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5544907
            Orig. end                         :: 5567225
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            MCOK01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22318
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="13"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22318
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22318
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12318](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12318
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    934..943
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     gene            complement(1243..1491)
                     /locus_tag="NOSIN_RS23930"
                     /old_locus_tag="NOSIN_23620"
     CDS             complement(1243..1491)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019607357.1"
                     /locus_tag="NOSIN_RS23930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_23620"
                     /product="hypothetical protein"
                     /protein_id="WP_077692893.1"
                     /transl_table=11
                     /translation="MSTTSVTTTVQLSISQPDAEDVRVFWREDNPELLALALVDVAPGV
                     TLHLHDDSRDRPYLDKLIATLSEVRDRMSEQARDQGA"
     gene            1868..2752
                     /locus_tag="NOSIN_RS23935"
                     /old_locus_tag="NOSIN_23625"
     CDS             1868..2752
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR02587.1"
                     /locus_tag="NOSIN_RS23935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_23625"
                     /product="TIGR02587 family membrane protein"
                     /protein_id="WP_077692894.1"
                     /transl_table=11
                     /translation="MTGSRRAAGEGTRQEWREAGRDVARAVSGGMVVGIPLLYTMESWW
                     AGANVSPPYLLAGLLACLVPVFLLVFVTGFWSRPPNHLGGTVMQTVQAVGISYAVAGVV
                     LFALARVTWSMPLADAVGRLTYEAIPFALGAGLASTMVGGSSSREPQDQENGHRHSRAE
                     ATVKDIGITAVGAVVIGMAIAPTDEIPLLVAGVGGIRLLAVIALSLVVSYMIVFASGFL
                     DERKRRAQRGVLQHPVTETVTAYLVSLLVSAVLLALFQNLALDAPLEETVARIVVLGFP
                     AAIGGSAGRLVVG"
     gene            2749..3177
                     /locus_tag="NOSIN_RS23940"
                     /old_locus_tag="NOSIN_23630"
     CDS             2749..3177
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NOSIN_RS23940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NOSIN_23630"
                     /product="hypothetical protein"
                     /protein_id="WP_077692895.1"
                     /transl_table=11
                     /translation="MSGDERGRDRQQRKRDGEDNEEAHKRSAAEWTMLAVSAAVLLVIV
                     VAVAWLWLAGESRPPAFSTTARPMREVSGTVYVPVEVRNEGTRTAAGVQVVMEGPDGKE
                     LADQRIDFLSGGETTTVTFVLPEPRPGLGFAVSSYQRP"
     misc_feature    complement(3606..3625)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: medium, score: 24.11"
                     /tool="antismash"
     misc_feature    complement(3608..3622)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.09"
                     /tool="antismash"
     gene            4165..4755
                     /locus_tag="NOSIN_RS23945"
                     /old_locus_tag="NOSIN_23635"
     CDS             4165..4755
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017563148.1"
                     /locus_tag="NOSIN_RS23945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_23635"
                     /product="DUF305 domain-containing protein"
                     /protein_id="WP_077692896.1"
                     /transl_table=11
                     /translation="MAENAEGNDHQQGGGLSHQNKMYLRFAAMILTAMVVMYWTMFVGT
                     WEWSHVQWSESRLFMALTMGGAMGLVMLAWMLDMYKNMKGNIAIVVASLLLLGGGVFLD
                     RSQATVQDTAWMSSMIPHHSLAITRSERAEITDVRVCRLAVEIIAAQEREISEMEWLMK
                     DIEENGEAETLEEAKARPVPDFEGSPLRECPPD"
     misc_feature    complement(4815..4828)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.86"
                     /tool="antismash"
     misc_feature    complement(5431..5440)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 16.08"
                     /tool="antismash"
     misc_feature    5450..5466
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.64"
                     /tool="antismash"
     gene            5466..6260
                     /locus_tag="NOSIN_RS23955"
                     /old_locus_tag="NOSIN_23645"
     CDS             5466..6260
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NOSIN_RS23955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NOSIN_23645"
                     /product="hypothetical protein"
                     /protein_id="WP_077692897.1"
                     /transl_table=11
                     /translation="MNEQEDIITHLGGPGILAGLSWAYRSACGRTLDTYSEADGHDGSW
                     FGNTRHTLLRNRLNRVFSCDRYAGDEGVDEDLLYAELAAKDRVTMPNLDPGLVRLADLQ
                     SSPGWAFEQYRFLLASCKYGAIDQIPWPSKSPTKQRVARQFSPDPRQPTLFDWFVEEEV
                     DGLEAALVNRDELDLVTFVVAHSLDPITGKMELVFGRPKLNFGGGAAWHWRQDLLSLPP
                     FHGNRRIDDTPLPTGPSTVPDAPVRLRRATEERLGDRASVDK"
     gene            6257..7456
                     /locus_tag="NOSIN_RS23960"
     CDS             6257..7456
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017885.5"
                     /locus_tag="NOSIN_RS23960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ImmA/IrrE family metallo-endopeptidase"
                     /protein_id="WP_077692898.1"
                     /transl_table=11
                     /translation="MSFRTTTTDRAAGAAALFDRARLTLARQLAGLRKSELAALVGKSP
                     TAVTAWESGAKSPSPATVAQLALSLSIDPGFFATRADDVAALSTTPHFRSLRSTSQLAR
                     DQAFAYGQLAVDISTSLEKHVEFPNPDIPSEPVLIEDHDDDGPERAALAVRKIWGIEEG
                     PIGHLIRLVEHRGILVVFSPPQAASVDAYSFDSRLRPVMVLNPIKRDYYRQRFDVAHEL
                     GHLVMHTDAEPGGRIVENQANRFASELLMPSDEVRNLLPNSMGGDAWRSLARLKERWGV
                     SIQALLYRARQLGVLSDVSYRNAMTTVSARGWRRGEPGLVTALEQPSLLPRAVELLGKE
                     GISEVSLIEQCRVPDTLFRTVTSRKPSVGATEFTEPEGKEFRKANARVVSLLDKIQENR
                     "
     misc_feature    7575..7592
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.65"
                     /tool="antismash"
     gene            7735..8265
                     /locus_tag="NOSIN_RS23965"
                     /old_locus_tag="NOSIN_23650"
     CDS             7735..8265
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017571166.1"
                     /locus_tag="NOSIN_RS23965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_23650"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_077692899.1"
                     /transl_table=11
                     /translation="MSTQWTIHGEKLVDENRHIRLSTVDVTLPDGVSFTQYVVAMPPAA
                     MTLVVNDQREALLMRRHRFIIDRWVWELPGGYVDGAEDIGAAAAREVEEETGWRPRSME
                     HMVTFQPAIGSVDQPQIIYLARGADLTDTSPDVNEAQEIRWWPLGEAVEMIARGEVIGA
                     STVVALYRAITLV"
     gene            complement(8252..9595)
                     /locus_tag="NOSIN_RS23970"
                     /old_locus_tag="NOSIN_23655"
     CDS             complement(8252..9595)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017573783.1"
                     /locus_tag="NOSIN_RS23970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_23655"
                     /product="hypothetical protein"
                     /protein_id="WP_077692900.1"
                     /transl_table=11
                     /translation="MTRAPKQPNIQLVELLDEAGMPAKGLARRVVARGREQGLVLSYDH
                     NSVRRWMSGERPQRLVPGIIAGVLSEALGRPVLPEDCGLPEDEGQTLEFPLAWTAGITT
                     AGQLYRADGERRRDLLGGYSTAAYPSATVRWLTQPFVAGPAHRGRIRVGQPEISAIRQM
                     TRAFRDLDNRVGGGRIRSTVVQYLDANVAPLLRGSYTEEIGRDLFSAAAELTKAVGWMA
                     YDCEEHGLAQRYLIQALRMAQTSGDDGLCAEILAAMGHQATYIGRSAEAVDLARAAQSA
                     ALRAGHPALAAECHLIEAHGHAGLSDPRATSRSLRAGVKAFETDDPNPPEWLAYFDNAY
                     LAAKVAHCFLALGNDAQTAVYAKQSLRMNTDYVRGRTFNLLMLATAHAIDEPDEAVRVG
                     GVALDLVEGLQSQRALSYLRRLRSRLRPHEKLPEVEEFTVRAKEVIPG"
     misc_feature    complement(8846..8848)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            9811..9939
                     /locus_tag="NOSIN_RS26975"
     CDS             9811..9939
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017573784.1"
                     /locus_tag="NOSIN_RS26975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="albusnodin family lasso peptide"
                     /protein_id="WP_143832991.1"
                     /transl_table=11
                     /translation="MDNVKAEGQETHEELLVELGDVAELTLGQGQAQNENKRNPYN"
     gene            10001..11695
                     /locus_tag="NOSIN_RS23975"
                     /old_locus_tag="NOSIN_23660"
     CDS             10001..11695
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013155481.1"
                     /locus_tag="NOSIN_RS23975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_23660"
                     /product="albusnodin/ikarugamycin family macrolactam
                     cyclase"
                     /protein_id="WP_077692901.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.6e-27, bitscore:
                     95.3, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWFGGSTGLPPLARPRGSIPLAPHLPQVWTSSDWPDHERRVASHR
                     GRHVVVLGPCGVDEEELVRVTGHSVPDDVAWRWPGSYVVAQIEPGTVTIWTDLASAIPV
                     YTRRTPEGVLWASSSRLLAGFDEKPSVNLDKVAARLVSPDTAEAGMDSFFHRIERVPPG
                     HRFRLTVCREPDTRVMWRPTPMADGHALRLRSALEDAVAVRVDHSAQPSTDFSGGFDST
                     ALGLLAAECLAPEGRGIVGVTVHPEGVHHGGDLDYAREAAHHPRLDHRWMPVTDDHTPY
                     GKLDLVPATDEPAPSTVSYAYFSGQLTWLTEEVGSDMHMTGDGGDALLFTPPYYLVELL
                     KRGRIRRALGEAARWAHVRRMSILDAFRTANSRAEPDPVPSWAGAKQPVVGGEDPFSLE
                     SPTLRALMRTMAQAGRTARSDVQIAEAFGIALHNPYFDSQVIDAYLSVPVDSLPGPSRY
                     KPIMAEAMRDLFPERLARRTTKGDASSDHHHGLRKALPALLDFMDGHLAGEGLVDVAGL
                     RGSMRRAAMGVGDELAQVESAVATEAWLRAVRSAPAIPWEKIEARAA"
     gene            11884..12318
                     /locus_tag="NOSIN_RS23980"
                     /old_locus_tag="NOSIN_23665"
     CDS             11884..12318
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033537.1"
                     /locus_tag="NOSIN_RS23980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_23665"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_227014529.1"
                     /sec_met_domain="PF13471 (E-value: 1e-21, bitscore: 75.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGFSEFPRVPGPYRWAAVAALLLVLAVSWGGRRRFRMRRMLRLME
                     FASRLHRRPADTHQAEKAVHAVRALGLFSPVRVACLEESVAAVLALAIRGRGVRWCHGV
                     IADPIRLHAWIEVEGRPVEEPDSTRRCTALLTIPSMKEST"
     gene            12315..12890
                     /locus_tag="NOSIN_RS23985"
                     /old_locus_tag="NOSIN_23670"
     CDS             12315..12890
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013155483.1"
                     /locus_tag="NOSIN_RS23985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_23670"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_077692903.1"
                     /transl_table=11
                     /translation="MSEPLMWLRGDKAGIGPLRADLAEEYWRWEQSIPTIVGYNRQTPQ
                     PMETTREILVEGYGRASDRELRFTFYDLSGDEPSPVGLAQVYVDPMRRNGEYVVAMGES
                     RGKGVGSEATRLVLDYAFHVTNLRCVYLTVIEPNAGAIRAYEKAGFKRQGIRRNSNQWL
                     GETVNDVLMDAVPEDVPWKSLVKAQFTT"
     gene            complement(12933..13118)
                     /locus_tag="NOSIN_RS23990"
                     /old_locus_tag="NOSIN_23675"
     CDS             complement(12933..13118)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013155484.1"
                     /locus_tag="NOSIN_RS23990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_23675"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_077693751.1"
                     /transl_table=11
                     /translation="MSIPTKPWHKSSYSNEAGTCVEVSEGAVTGVRDSQNPHLVSLEFP
                     ASAWTGFLSGIGSPRT"
     gene            complement(13133..14026)
                     /locus_tag="NOSIN_RS23995"
                     /old_locus_tag="NOSIN_23680"
     CDS             complement(13133..14026)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017573789.1"
                     /locus_tag="NOSIN_RS23995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_23680"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_077692904.1"
                     /transl_table=11
                     /translation="MTTPAQRRQEVEMPEGTPVQGSPARRHYLISQLKRLRARTGLSQE
                     EAAEEMGWHKSKVSRIENGKWKRLSGPEIDALCRFYTAPDELREELTHIAKAASRNRSS
                     AWWNAYEDIPGGAYYPLEYEADQIFEYTLGLFSGLAQHPDYIRALMGRGAVPDEAERER
                     RLEARVERTRSILYREAPPRMWWVIDEPVLTCQVGGPKVMRTQLEHLLELSDHPRIDLQ
                     VLPQSEGMSLNYGFCLLWIGDDRVGHVDVPPQGLLFDAPEDVQHHELRSNHLRAAAMSQ
                     ERSRDLIRTRITELDA"
     gene            14241..14684
                     /locus_tag="NOSIN_RS24000"
                     /old_locus_tag="NOSIN_23685"
     CDS             14241..14684
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013155486.1"
                     /locus_tag="NOSIN_RS24000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_23685"
                     /product="ATP-binding protein"
                     /protein_id="WP_236743435.1"
                     /transl_table=11
                     /translation="MDVGLARGLVDHALVAAGVGEAGRAAARLAVSEAFTNALVHGRPE
                     VGVEVWSKPGHCAVIEVYDTEATVPVFPQTWELADAVAEHGRGLGLIQAFTREVCGAYR
                     CGEGKRVWFAVAQDGGEIDADAVRCLVAERARRRVSGVSFTAA"
     tRNA            complement(15118..15244)
                     /anticodon=(pos:complement(5560065..5560067),aa:Lys,
                     seq:ttt)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="NOSIN_RS27365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Lys"
     gene            complement(15118..15244)
                     /locus_tag="NOSIN_RS27365"
     gene            complement(15538..16014)
                     /locus_tag="NOSIN_RS24005"
                     /old_locus_tag="NOSIN_23690"
     CDS             complement(15538..16014)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017566911.1"
                     /locus_tag="NOSIN_RS24005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_23690"
                     /product="nitroreductase/quinone reductase family protein"
                     /protein_id="WP_077692906.1"
                     /transl_table=11
                     /translation="MSTPDTTGSNDSAQDASLSHLPNHIRRAIEITPAAGTRERIIDIT
                     TLGRRTGRPRRIEIFFYRAADTTYLCSGAGGAATDWHANLLANPDLTFHLKNGIRADLP
                     ARATPVTDPAERQAVLAEIVTDLNQPHDPGTIRPTRLEDWVSSRLMRISFHHQP"
     gene            complement(16011..16790)
                     /locus_tag="NOSIN_RS24010"
                     /old_locus_tag="NOSIN_23695"
     CDS             complement(16011..16790)
                     /EC_number="1.1.1.47"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-167). E-value: 1.1e-10. Score:
                     33.6. Matches aSDomain:
                     nrpspksdomains_NOSIN_RS24010_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017566912.1"
                     /locus_tag="NOSIN_RS24010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_23695"
                     /product="glucose 1-dehydrogenase"
                     /protein_id="WP_077692907.1"
                     /sec_met_domain="adh_short (E-value: 3.6e-30, bitscore:
                     103.6, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRFDNQTVLVTGGTGGQGASHARAFHAEGANVVIGDIDAERGAA
                     LADELGTRARFVRLDVTDQGSWASAVLAAESAFGAVNVLVNNAGVQNPPAPIEHTDQAT
                     WSRILDINLTGIFLGIKVAVPALRRAAGGAIVNIASTMGLGGTAHYAPYVASKWAVRGL
                     TQTAALELGRDHIRVNTIHPGVIATPFIQEPAAGATAAIADFYSPEPFAIPRLGEPTDV
                     SRLLLFLTSSEASFITGSEYVIDGGLLLGPALQSETV"
     aSDomain        complement(16290..16769)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NOSIN_RS24010_PKS_KR.1"
                     /evalue="1.10E-10"
                     /label="NOSIN_RS24010_PKS_KR.1"
                     /locus_tag="NOSIN_RS24010"
                     /protein_end="167"
                     /protein_start="7"
                     /score="33.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TVLVTGGTGGQGASHARAFHAEGANVVIGDIDAERGAALADELGT
                     RARFVRLDVTDQGSWASAVLAAESAFGAVNVLVNNAGVQNPPAPIEHTDQATWSRILDI
                     NLTGIFLGIKVAVPALRRAAGGAIVNIASTMGLGGTAHYAPYVASKWAVRGLTQTA"
     CDS_motif       complement(16656..16769)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NOSIN_RS24010_0001"
                     /evalue="4.20E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="NOSIN_RS24010"
                     /protein_end="45"
                     /protein_start="7"
                     /score="13.0"
                     /tool="antismash"
                     /translation="TVLVTGGTGGQGASHARAFHAEGANVVIGDIDAERGAA"
     gene            16936..17580
                     /locus_tag="NOSIN_RS24015"
                     /old_locus_tag="NOSIN_23700"
     CDS             16936..17580
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017566913.1"
                     /locus_tag="NOSIN_RS24015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_23700"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_077692908.1"
                     /transl_table=11
                     /translation="MSRVVTTYHQRVAQEKRALIVTAATALFLELGYDRTSLARIAESS
                     GVSRATLFKQFPSKAALFDAIVTESWSTADEEDPPSAGNVVDGLGIIGRRYAELLGRAQ
                     MTDLFRIVIAELPRFPELAHAQFSHGKMPYFESLRSYLLAEHEAGTVRVEDVDLAATQF
                     LGMISNYVFWPTLLVPGWEVSAERVAQVVDEAVRTIVARYSATGPGPSTNS"
     gene            18109..18948
                     /locus_tag="NOSIN_RS24020"
                     /old_locus_tag="NOSIN_23705"
     CDS             18109..18948
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017559579.1"
                     /locus_tag="NOSIN_RS24020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_23705"
                     /product="site-specific integrase"
                     /protein_id="WP_227014498.1"
                     /transl_table=11
                     /translation="MKLTSGRRPRPVLWTQDAQREWERGGDRPAVAVWSVQHTRSFLDF
                     VAGHRLYALFHLVVLLGLRRGEVLGLRWRDVDLDARVLHVESQVQQVGGCVVVAEPKSE
                     ASRRTVALDQVTVQVLRAHRRKQQSERSGTGRADPDLVFTCIKGGCLAPDRLSRSFRKL
                     NTESGLPPVRLHDLRHGAATFALAAGVDLKTVQAMLGHASIVLTADTYTSVLPEVAHEA
                     AEATAALVLRDARSARVRHRALRRRRKRRGGPMRAPPGSHQGNARRGSAGVIPGERW"
     tRNA            complement(18943..19018)
                     /anticodon=(pos:complement(5563890..5563892),aa:Lys,
                     seq:ttt)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="NOSIN_RS24025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="NOSIN_23710"
                     /product="tRNA-Lys"
     gene            complement(18943..19018)
                     /locus_tag="NOSIN_RS24025"
                     /old_locus_tag="NOSIN_23710"
     gene            19219..19605
                     /locus_tag="NOSIN_RS24030"
                     /old_locus_tag="NOSIN_23715"
     CDS             19219..19605
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017563838.1"
                     /locus_tag="NOSIN_RS24030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_23715"
                     /product="PPOX class F420-dependent oxidoreductase"
                     /protein_id="WP_077692909.1"
                     /transl_table=11
                     /translation="MAFSEKQQAVLRKPAFGHVATLGPDGGPQSSPVWIDWDGEFLRFS
                     QTTTRQKLHNLKRDGRIAVSAVDPDDPYMYVEVRGVCDRVEKDEDKAFINEMSQKYLGK
                     PYPWDDPQEERVIVYVRPERFVGR"
     gene            19736..20350
                     /locus_tag="NOSIN_RS24035"
                     /old_locus_tag="NOSIN_23720"
     CDS             19736..20350
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017573795.1"
                     /locus_tag="NOSIN_RS24035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_23720"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_077692910.1"
                     /transl_table=11
                     /translation="MGLRERKKQATRRALQDAAVSLTLERGLENVTVEEIAAEADVSTR
                     TFFNYFATKEDALLGDVPETPDEEARREFVGGGPTGDFVEDLITVLITFLVSTDDLATQ
                     RADMRLRRELMEREPQLVRGMLARFHNVEMELAAAIAERTGASAGDDRPLLVAASAMSV
                     MRHTMKSLHFSESEETADVRAKIRAAFRHLGEAYGPSAPNG"
     gene            20400..21998
                     /locus_tag="NOSIN_RS24040"
                     /old_locus_tag="NOSIN_23725"
     CDS             20400..21998
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620779.1"
                     /locus_tag="NOSIN_RS24040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_23725"
                     /product="MDR family MFS transporter"
                     /protein_id="WP_077692911.1"
                     /transl_table=11
                     /translation="MPTTPSRTRLRWIFLAIILTMLLASLDQTIVATALPTIVGELNGL
                     EHLSWVVTAYMLAATVGMPIYGKAGDIFGRRHVYLFAIVVFLLGSVLSGLAQDMTQLIL
                     FRALQGIGGGGLMISAQAIIADVVSPRERGKYMGIMGAVFGVSSIAGPLLGGFFTDQLD
                     WRWIFYINLPLGAVALVAAATMIRLPKPEGPRPKLDYTGTVLLAATSVCLVLLTSWGGH
                     TYDWVSPQILGLGAAAIAAAFLFVLVERRAAEPIIPLRLFRDRDFVLTALIGITVGIAM
                     FSTVSYLPTFLQMVKGATATESGLLMLPMVLGMLISTITTGRLISATGRYKHWPIIGTA
                     IITVGLVLLSRMDADTPYLYNGSAMLVMGLGVGMVMQNLVLIVQNTAPRRDLGAATSAN
                     NYFRQIGASFGIAVFGSVFVSRLNERMAGIPGGSLEFEGGEAGISSMTPQMLQGLPGPV
                     REFVVHAFAGALPPIFLYVVPIALVGFALSWFITEKPLATTVGGTEQGKESTEGAESGP
                     REGRDVRGGDVRDSV"
ORIGIN
        1 caggccggtg tcggggttgc gcggaagccc cacctcgggg tcgatctccc agccggtcac
       61 cgggtcgacc gtcggaacgg cttcgtcgga gggcccgccg gagggtgcct cggagggccc
      121 ggagggggcg gccgagggct ccggggacgg gtcggaggcg gatccgggct cctggtcctc
      181 ctcctgggga ccccgctcct cggagacgat ctcgctctcg gcgggctgtg ccccggcgcc
      241 gccctgcggg tcgatcacgt cccagctcac cagggccagg acgaggatgc ccagggcgat
      301 gcggtagtag acgaacggca tgaagctgtg cgtggagatg aagcgcatca gccaggcgat
      361 caccacgaag ccgaccacgc ccgcgatgac cgttcccagg atggtggccc cccacccggc
      421 gtactcggcg ctaccgatgt cggtcagttt gtacaggccc gcgccgaaga ccgcgggcag
      481 cgccagcagg aaggcgtact cggccgcgtc cttgcgctgg aagttgagca gcatcccacc
      541 cgtgagggtg ccgcccgagc gggagacgcc cgggatcagg gcgagtgcct ggaagaggcc
      601 gaaggtcagg ccgcggggga cgttgaggtc ctccaggctc cggtacttgc gcgtgtacct
      661 gtccaccacg ccgaggatca cgccgaagac gatgaggttc agcgcgatca ggcgcaggtc
      721 ccggaagacg ctgtcgatct gctcctccag gagcaggccg aggaccacga tggggaccga
      781 gccgaggatg acgtaccagc ccatgcgcgc gttgatgtcg ccgcgcaggt cccggttgac
      841 cagtgaccgg gaccacgtcg acaggatcgc ccagacccgc tcccggaagt agatcagcac
      901 ggccagctcc gtgccgagct ggctgacggc agtgaaggcg gcgccgggat cgggccagcc
      961 gaagaacgcc gacaccacgc gcaggtgccc gctggaggag atcgggagga actcggtcag
     1021 cccctggacc aggccaagga tgattgcttc gaagatggac acggcagagt ctgctccagg
     1081 ctgcttcggt cgccggtggg gcgacgactg tctcgggcac ggcgaggcgc gctcgggaaa
     1141 aggggacggt ccacgaagct tactgagaac tccggatcag cacgtcactg aggagcgggg
     1201 tgcgggcggc cgcgcggccg cacggccgcc cgacggcgtg gctcaggcgc cctggtcccg
     1261 ggcctgctcg gacatccggt cgcgtacctc ggacagggtc gcgatcagtt tgtccaggta
     1321 ggggcggtcc ctgctgtcgt cgtgcaggtg cagggtcacc ccgggtgcca cgtcgaccag
     1381 ggccagggcc aggagttcgg ggttgtcctc gcgccagaac accctgacgt cctcggcgtc
     1441 gggctggctg atggagagct ggacggtggt ggtgaccgag gtggtgctca cggtgtgcct
     1501 cctacggggt cggtgaggga ccggaccggg cggatcgcct gctggccgga ccagaggaga
     1561 gcgggccgga tcacccggtt ccggcgttcg cgagcgcggc cgtgacccgg cctgtccgtc
     1621 tcggtgcgcc tgttcacggc cgttacctac ccgatgggcg ggccgctgcc catcacagct
     1681 ggacaacgga tccgggtccg tgtccggtga tcgtggcgtc gcgttgtgta attggcgttc
     1741 gttgtgggaa gcggatggtg gaccggcgga tccccacacg tcttcgaggg gcctcctcga
     1801 acaggagagg gggcggttcc gcaccgggtc ggtcgcgccg ggacgcgtgc gacggaggga
     1861 ggcgcaggtg acggggagca ggagggcggc gggggagggg acccgccagg agtggcgcga
     1921 ggcgggcagg gacgtcgcac gggccgtcag cggggggatg gtcgtcggga tcccgctgct
     1981 gtacacgatg gagtcctggt gggcgggggc gaacgtctcc ccgccctacc tcctggccgg
     2041 cctgctcgcc tgcctcgtgc cggtcttcct cctcgtcttc gtcacgggtt tttggtcccg
     2101 gcccccgaac cacctcggcg gcaccgtgat gcagacggtc caggcggtcg gcatctccta
     2161 cgccgtggcg ggcgtggtcc tgttcgccct ggcgagggtg acctggtcga tgccgctggc
     2221 ggacgcggtg ggacggctga cgtacgaggc catccccttc gcgctcggcg cggggctggc
     2281 ctccaccatg gtgggcggct cgtccagccg ggagccgcag gaccaggaga acgggcaccg
     2341 ccactcccgg gccgaggcga cggtcaagga catcgggatc accgcggtcg gcgcggtggt
     2401 gatcgggatg gcgatcgccc ccaccgacga gataccgctc ctcgtggccg gtgtcggggg
     2461 gatacggctg ctggccgtca tcgccctgtc cctggtggtc tcctacatga tcgtgttcgc
     2521 ctccggcttc ctcgacgagc gcaagcgccg ggcgcagcgc ggcgtgctcc agcacccggt
     2581 caccgagacc gtcaccgcct acctggtgtc cctcctggtc tcggccgtgc tgctcgcgct
     2641 cttccagaac ctggcactcg acgctccctt ggaagagacg gtggccagga tcgtggtact
     2701 cggattcccc gccgcgatcg gcggcagcgc aggaaggctg gtggtgggat gagcggcgac
     2761 gaacgaggcc gcgacaggca gcagaggaag cgggacggcg aggacaacga ggaggcgcac
     2821 aagcggagcg cggcggagtg gacgatgctg gccgtgtccg cggcggtcct gctcgtgatc
     2881 gtcgtggccg tggcctggct gtggctggcg ggtgagagcc gtccccccgc cttcagcacc
     2941 acggcccgtc cgatgcggga ggtctccggc accgtgtacg tgcccgtgga ggtccgcaac
     3001 gagggcaccc gcacggcggc cggcgtgcag gtcgtgatgg agggccccga tgggaaggag
     3061 ctggccgacc agcgcatcga cttcctcagc ggcggggaga cgaccaccgt caccttcgtc
     3121 ctgcccgagc cccgccccgg cctcggtttc gcggtgtcca gctaccagag gccgtgaggg
     3181 gccgcccgac acccgcgtac ggctcggggt gctccgccgc gcaggggctg tcgccgccgg
     3241 ctccctccgg agcctcgccg ggccgcgtcg accagatctc cacgggcagg gggctagccg
     3301 acacggtgga agcgccctgt ccttccacac ggaaggacgg gggcgccgtc cttcgccagg
     3361 gctgccccca cgggctccca ggaggcgggg aacggcgaag ggcgctcccc gcccggaggg
     3421 agcgcccagg tgaaacggtc gcgaggtggt ggggtccagg ggatcgaacc ctgaacccgc
     3481 ggatcaaaag tccaggtgga agcgagctac ccgccccggt gcgtggttct ttgttcgtcc
     3541 gtgcccgggt gacgtcatga tctcaccgcg atgttcgggg gtgtgagggg tcgctcgtct
     3601 tcgtgctcgg gacggtcggc ccagagcttc gtcgtagtcg ctagggccaa ggtggcgtgc
     3661 acccgggcgg tggcggtcgg aatcgccgac cgctcgggag gcgctgatct ggtccgccgc
     3721 atgaccggcc ggactgtcgg ccggcagcgc gggcgggccg gtgcggtcgc agaaggtcag
     3781 cccgccgcgg tcgacgtcga cgcggtcgtg ggcgaacacg tcggcgtcga gggcttccca
     3841 gacgtccggg gcgctgacca cgtcaagttc cccggtcgag acctgcgccc ggctggttgg
     3901 gggctgtcag cacctgctgc cacaggcccg tcaccggtaa tcgcgcgcga tgtcggcttc
     3961 gtagccggtg tggcgggacg gagcagcggc ggtactcggc cccacggcat cgccgcctgc
     4021 accacgcggt cctcggcgtt gcgcgggagc cccctccgcc acggcccgtt tcggcgtcac
     4081 cagacaagga tagaggcgtt agacggcggg gcgggggcgc gtgtggaccc cttccaccga
     4141 taacgacgga acggagaccc atccatggcg gagaacgccg aggggaacga ccaccaacag
     4201 ggtggcggcc tgtcgcacca gaacaagatg tacctgcgct tcgcagccat gatcttgacc
     4261 gccatggtcg tcatgtactg gaccatgttc gtcggcacgt gggagtggag ccacgtgcag
     4321 tggagcgaga gccgcctgtt catggcactc accatgggtg gcgccatggg gctggtcatg
     4381 ctcgcgtgga tgctcgacat gtacaagaac atgaagggca acatcgccat agtggtggcg
     4441 agcctcctgc tgctgggcgg cggcgtgttc ctcgaccgca gtcaggccac cgtgcaggac
     4501 accgcctgga tgagctcgat gatcccgcac cactcgctgg ccatcacccg atccgagcgc
     4561 gccgagatca ccgacgtccg ggtgtgccgg ctggccgtcg agatcatcgc tgcccaggag
     4621 cgggagatca gcgagatgga gtggctgatg aaggacatcg aggagaacgg ggaggccgag
     4681 acgctcgagg aggcgaaggc ccggcccgtt cccgatttcg aggggtcccc gctgcgtgag
     4741 tgcccaccgg actgacctgg gagatgctgc tgggtgtccg gggccgtgcg gcagggtcat
     4801 gggggtcccg gtggttttca cggaaaatcc aacgcctagc gttcggttct ccgtgacacc
     4861 tgccgctcag ccgccgtcgg ggaggcgggg agccgggcta ctgccacctc catgtcggcc
     4921 tcggcggaca gcgcgcagcg tcgggtggtg tccagccgcc tgtgccccgt caaccgcgcc
     4981 acggtcgtta tccttgcccg cccgcgatga tctggcccta gcgggtcgag acgagaaaac
     5041 cccaggtcga tggcggcggg aagccgctct gacccggggt ctcgtgtggt agggccccag
     5101 gggatcgaac cctgaacccg cggattaaaa gtccgctgct ttccgtgtgt tttgcccggt
     5161 aggcgatgtt tcgtgcgtcc gtatccggga gccgctgtgc taccggagac cacagaagtc
     5221 caccccgtac taccgggctc ccgaacagcg gagccacgac ggagctaatc cggccgcccc
     5281 tgaggtgcgg atcgagtccg ctgggacctt ggcggcttcg gggcgaagct tactggtcac
     5341 gtggcttcgg cggagtctgc tggtgtcggt ggcatggagg cgcgagggtg ggatcaacgg
     5401 catgatgcga ctcagatggt tgaatcctga tcacaaaata ctggatatgg tgtagcttta
     5461 ctcccgtgaa cgaacaggaa gacatcatca cccacctcgg tgggcccgga atccttgccg
     5521 gtttgagctg ggcgtatcgt tcggcttgtg gccggacctt ggacacctac tccgaagctg
     5581 acggtcatga tgggagctgg ttcggtaaca cgagacacac cctgctccgc aaccggctga
     5641 accgagtgtt ctcctgcgat cgctatgccg gcgatgaggg agttgatgag gacctcctct
     5701 acgctgagct ggctgccaag gacagggtca ccatgcccaa ccttgaccct ggtctagtgc
     5761 gcctcgccga tcttcagagc agccccggct gggccttcga gcagtaccgc tttcttctgg
     5821 cttcgtgcaa gtacggtgcg attgatcaga ttccttggcc ctcgaagagc cccaccaagc
     5881 agcgggttgc gcggcaattt agcccggatc cgcgtcagcc gaccttgttc gactggttcg
     5941 tggaggaaga ggtcgacggc ttggaggcgg ctctagtgaa ccgggacgag ctcgatctgg
     6001 tgacgtttgt cgttgctcac agcctcgatc ccatcactgg aaaaatggaa ctcgtctttg
     6061 gccgtcccaa actcaacttc ggagggggag ccgcctggca ctggcggcag gacctcttga
     6121 gcctccctcc cttccatgga aaccgtcgca tcgatgacac tccgctgcct accgggccga
     6181 gcacggttcc ggatgctccc gttcggctgc gtcgtgccac ggaagaacga ctcggtgatc
     6241 gtgcgagtgt agacaagtga gctttcgaac cactacgacc gaccgagcag ccggtgccgc
     6301 tgctctcttc gaccgagcgc gtttgacctt ggcacgacag ctagcaggtt tgcgcaagag
     6361 cgagctggct gctctggttg gcaagagtcc taccgcagtc acagcctggg aatctggagc
     6421 taagagccct tcgcccgcaa cagttgccca gttggcgctg agtttgtcaa tcgacccggg
     6481 gttctttgct acccgagcag atgatgttgc cgccttgagc accacacccc acttccgctc
     6541 tctacgttcg actagtcagc ttgctcggga ccaagctttc gcctacggtc aactggctgt
     6601 tgacatttcg acaagcttgg aaaaacacgt cgagtttccc aaccccgata ttcctagtga
     6661 gcctgtcttg atagaggatc acgacgatga tggacctgag cgtgctgcgc tcgcagttcg
     6721 taaaatctgg gggattgagg aagggccgat tggtcatctc attcgtctgg ttgaacatcg
     6781 cgggattttg gtagttttta gcccgccaca ggcggcatca gtggatgcgt actcttttga
     6841 tagcaggctg cgccccgtga tggtcttgaa tccaatcaag cgtgattact atcggcaacg
     6901 ttttgatgtc gcccacgagc tgggccacct ggttatgcat accgatgctg aaccaggagg
     6961 gcgtatcgtg gagaaccagg caaatcgctt tgcttccgag ttgctgatgc catctgatga
     7021 ggtcagaaac ttgttgccga atagtatggg tggtgacgct tggaggtcac ttgcccgttt
     7081 gaaggaacgg tggggcgtga gtattcaggc tttgctttac cgtgcccgtc aactcggggt
     7141 cctcagtgac gtatcctatc gaaacgccat gaccaccgtc tctgctcgtg gttggcgcag
     7201 gggtgaaccc gggcttgtga ctgctttgga gcaaccttcg ctcttgccca gagccgttga
     7261 acttctaggc aaagagggca tatctgaggt aagccttatt gagcagtgtc gtgtgcctga
     7321 tactttgttc cgcaccgtta cttctcgcaa gccgtcagtc ggggccacag aatttaccga
     7381 gccagaagga aaagaatttc gcaaggcaaa tgctcgagtg gtttcgctgc tagataaaat
     7441 ccaagagaac cggtgattaa actacaggtg cccgtgctcg gtctttacgg gctccgcgta
     7501 ttgctggtga ttggttcatg cgagggttgg tgatggtgat catcgattcg ctttttgggt
     7561 tggaatttcc gtaaatattg cgaaggtgtt aatcgtcggc attggctcgc gcacttagca
     7621 agggaatgcg tagatcggtc tgcagaggat actttgtgta ttcgatcttc agtgaggttg
     7681 atgtaggtca cccccgtaag ggggccgcgc tgcgttctgc tctagggtgc gggtgtgagc
     7741 acccaatgga cgatccacgg cgagaagctt gtggacgaga accggcatat ccgtctgtcc
     7801 acggtcgacg tcaccctccc ggacggtgtg tccttcacgc agtacgtcgt cgccatgcct
     7861 ccggcagcga tgacactggt ggtcaacgac cagcgcgaag ccctgctgat gcggcggcac
     7921 cggttcatca tcgaccggtg ggtgtgggaa ctgcccggag gctacgtcga cggtgccgag
     7981 gacatcggag ccgcggcggc acgcgaggtc gaggaggaga ccgggtggcg gccgcgctcg
     8041 atggagcaca tggtgacctt ccaacccgcc atcggatcgg tggatcagcc ccagatcatc
     8101 tacctggcac ggggcgccga cctcaccgat acctcgccag acgtcaacga ggcccaggag
     8161 atccgctggt ggccgctcgg ggaggcggtg gagatgattg ctcgaggaga ggtcatcggc
     8221 gcatccacgg ttgtcgccct gtaccgggcc atcaccctgg tatgacctcc ttggcccgta
     8281 ccgtgaactc ctccacctcc ggcagcttct cgtgaggccg cagcctgctc cgtagtcggc
     8341 gcaggtacga cagggcacgc tgtgactgca atccctccac caggtccaga gccaccccgc
     8401 cgacccgtac tgcttcatcc ggttcgtcga tggcatgtgc ggtggcgagc atcaggaggt
     8461 tgaacgtcct gccgcgtacg tagtcggtgt tcatcctcag ggactgcttg gcgtacacgg
     8521 ccgtctgggc gtcgttgccg agggcgagga agcagtgcgc gaccttggcc gcgaggtagg
     8581 cgttgtcgaa gtaggccagc cactccggag gattagggtc gtccgtctca aaggccttca
     8641 cacccgcccg cagggagcgg gacgtggccc gtgggtccga gagccctgcg tgcccgtgcg
     8701 cttcgatgag gtggcactcc gccgctagcg cggggtgccc ggcccggagc gcggcggact
     8761 gcgcagccct cgccaggtcc acggcttcgg ccgaccgccc gatataggtg gcctggtggc
     8821 ccatggccgc aaggatctcg gcgcataacc cgtcgtcccc ggacgtctgg gccatgcgca
     8881 gtgcctggat caggtaccgc tgggcgagac cgtgctcctc gcagtcgtag gccatccacc
     8941 ccacggcctt ggtgagttcg gcggccgccg agaacagatc ccggccgatc tcctccgtgt
     9001 aactgccccg tagcagcggg gcgacgttgg cgtcgaggta ctgcacgacg gtgctgcgga
     9061 tgcggccccc gccgacgcgg ttgtccaggt cccggaaagc gcgcgtcatc tgccggatgg
     9121 ccgagatctc gggctgtccg acacggatcc gtccgcggtg ggcgggacca gccacgaagg
     9181 gctgggtgag ccaccgcacg gtcgcgctcg ggtaggccgc cgtcgagtac ccgccgagga
     9241 gatcacggcg gcgctcaccg tcggcccggt agagctggcc ggcggtagtg atccccgcgg
     9301 tccaagccag agggaactcc agggtctgtc cctcgtcctc gggaagtccg cagtcctcgg
     9361 ggagcacggg acgccccagt gcttcggaga ggactcccgc gatgatcccg ggaaccagtc
     9421 gctgggggcg ttcgcccgac atccagcggc ggacgctgtt gtggtcgtag gagagcacca
     9481 aaccctgttc cctacctcgg gccactaccc tgcgggcgag ccctttggcg ggcattccgg
     9541 cctcgtccag gagctccacg agttggatgt tcggctgctt gggggcacgt gtcacggctt
     9601 cttctccaca ggtccgagtc gaaggcagtg tgacacggct gctgctgcgg gagtggggat
     9661 accgggaggc tcactccccc ttcacactcc ttccgaagga gcgcacgttc gtctcctgag
     9721 tccgcgcctt cacgggagcg gcaaggaagt ggacggtagg accggtaagc gccggtggcg
     9781 gaaccgtccg cgagagcgaa gcgagggctg atggacaacg tgaaggctga gggccaagag
     9841 acccacgagg aactgctggt cgaactgggc gacgtggccg aactgaccct cggtcagggg
     9901 caggcccaga acgagaacaa gcgcaacccc tacaactgac cgcctcgggt gcccggggca
     9961 accccttccg ggcacccgct cagagcgcag gagaaagccc atgtggttcg gtggttcgac
    10021 aggcctgccg cccctcgccc gcccccgtgg ttccatccct cttgctccgc atctgccgca
    10081 ggtatggacg agttctgact ggcccgacca cgagcgacgt gtcgcctctc accgagggcg
    10141 tcacgtagtg gtgctgggcc cttgcggcgt cgatgaggaa gaactggtcc gggttacggg
    10201 gcactctgtg cctgacgacg tggcctggcg gtggccgggc agctatgtcg tggcgcagat
    10261 cgagccggga acggtcacga tctggaccga tctcgcctcg gcgatcccgg tgtacacgcg
    10321 acgcactccc gaaggagtgc tgtgggcttc cagttcacgt ctgctggccg gcttcgacga
    10381 aaaaccgagc gtgaacctgg acaaggtcgc cgcacggttg gtcagccctg atacggcgga
    10441 ggccggaatg gattcttttt tccacaggat cgaacgcgtg ccacccggac accggttccg
    10501 actgaccgtt tgtcgtgaac cggacacgag ggtgatgtgg cgaccgaccc cgatggccga
    10561 cggtcacgca ctccggcttc gatccgcgct cgaagacgcc gtcgctgttc gtgtcgacca
    10621 ctcggcgcag ccgagcacgg acttctctgg tggattcgac tccacagcgc tcggactcct
    10681 ggccgcggaa tgcctggcac cggagggacg cgggatcgtg ggcgtcaccg ttcacccgga
    10741 aggcgtccat cacggcggag acctcgacta cgcccgagag gccgcccacc atccgagact
    10801 cgatcaccgc tggatgccgg tcactgacga ccacactccc tacgggaagc tcgatctggt
    10861 tcccgccacg gacgagccag caccatcgac ggtctcctat gcctacttct ctggccagtt
    10921 gacctggctc accgaagaag tcggctctga catgcacatg accggagacg gcggggatgc
    10981 tctcctcttc acgcccccgt actacctggt cgaactcctg aagcggggca ggatccggcg
    11041 ggctctcggt gaggcggcgc gttgggcgca cgtacggcgg atgtcgatcc tggacgcctt
    11101 ccgaaccgcg aactccaggg cagaaccgga cccggtcccg tcctgggctg gtgcgaagca
    11161 acccgtggtc ggcggcgagg accccttctc tctggagagc cctactctgc gtgccctgat
    11221 gcggacgatg gcccaggccg ggcgcacggc tcgctccgac gtacagatcg ccgaagcctt
    11281 cgggatcgcg ctccacaacc cctacttcga ctcccaggtc atcgacgcct atctgtccgt
    11341 gccggtcgac agccttccag ggccgtcccg ctacaagccg atcatggccg aggccatgcg
    11401 ggacctgttc ccagaacgcc ttgcccggcg caccacgaag ggggacgcct ccagcgacca
    11461 ccaccacggg ttgaggaagg cgctgcccgc actcctcgac ttcatggacg gccatctcgc
    11521 cggcgaaggg ctggtcgatg tcgccggatt gcgcggatcg atgcggcgcg ccgccatggg
    11581 cgtaggcgac gaactggccc aggtcgagtc cgccgtggcc accgaggcat ggctgcgcgc
    11641 ggtccgctcc gcgccggcga tcccatggga aaagatcgaa gcgagggcgg catgaaggtc
    11701 acgtctttcg gcctgtctga catccgtgcc tgcgatctgg gagcagcgac cgtggtcgtc
    11761 gactacggaa ccggcgcggt ccgtgtcatt tcttctgagg ccggaaggca ggcggccatg
    11821 gctgggacgc ctgccgtcag cggtcatagg tgggaggcga gctggggcgt tcaggagctc
    11881 ccgatggggt tctccgagtt cccccgagtt ccgggcccct accgatgggc tgccgtagca
    11941 gcgctcctcc tggtgctcgc tgtctcctgg ggcggccgac ggcggtttcg gatgaggcgg
    12001 atgctccggc tcatggagtt cgcttcgcgg ctacatcgcc gtccagccga tacgcaccag
    12061 gccgagaaag ccgtgcacgc ggtacgggct ctgggcttgt tctcgcccgt gcgcgtcgcg
    12121 tgcttggaag aatcggtggc cgcggtgctg gccctggcca tacgcgggcg tggagtgcgc
    12181 tggtgccatg gggtgatcgc ggatcccatc cggctgcacg cctggatcga ggtggagggc
    12241 cggcctgtgg aggagccgga cagcacacgg cggtgcaccg cactgctgac catccccagc
    12301 atgaaggaga gcacgtgagt gaacccctga tgtggcttcg aggggacaag gccgggatcg
    12361 gcccgttgcg cgccgatttg gcggaggaat actggcgatg ggagcagtcg atcccgacga
    12421 tcgtcggcta caaccggcag accccgcagc cgatggagac cacccgggag atcctggtcg
    12481 agggctacgg gcgtgcttcg gaccgggaac tgcggttcac cttctacgac ctgagcgggg
    12541 acgaaccatc tcctgtcggg ttggcccagg tgtacgtcga tccgatgcgc cgcaacggcg
    12601 agtacgtggt ggctatgggg gagtcccgag ggaagggtgt gggcagtgag gcgacccggc
    12661 tggtgctgga ctacgccttc cacgtgacca acctgcggtg cgtgtacctg acggtgatcg
    12721 aacccaacgc cggggcgatc cgcgcctacg agaaggccgg gttcaagcgg cagggcatac
    12781 gtcgcaactc caatcagtgg ttgggcgaga ccgtcaacga cgtgctgatg gacgcggttc
    12841 ccgaggatgt tccgtggaag tccctggtga aggcgcagtt cactacctga atcaacggct
    12901 gtgtgcccgc cgcctggcgg gcacacagag gttcaggttc tgggggagcc gatccccgag
    12961 agaaatccgg tccaggccga ggcggggaac tccagggaaa ccaggtgggg attctggctg
    13021 tcccggacac cggtgacggc tccttccgag acctccacgc acgtgccggc ctcgttgctg
    13081 tagctggact tgtgccaggg cttcgtcggg atgctcatct gtgtgacctc gttcatgcgt
    13141 cgagttcggt gattcgggtt cggatcaggt cgcgggaacg ctcttgggac atggctgcgg
    13201 cccggaggtg gttggacctc aactcgtggt gttgcacgtc ctcgggtgcg tcgaacaaca
    13261 gaccctgtgg cgggacatcc acgtgcccga cgcggtcgtc accgatccac agtaggcaga
    13321 acccgtagtt caggctcatg ccctcggact ggggcagaac ctggaggtcg attctggggt
    13381 ggtcgctcag ctccaggagg tgttcgagct gagtgcgcat caccttgggg ccacccacct
    13441 ggcaggtgag gaccggctcg tcgatgaccc accacatccg aggaggagct tcgcgataga
    13501 ggatgctgcg ggtccgttcc actcgggctt ccagcctgcg ctctcgctcc gcctcgtcgg
    13561 gtaccgctcc gcgacccatc agggctcgaa tgtagtcagg gtgctgggcc aggccgctga
    13621 agagcccgag cgtgtactcg aagatctggt cggcctcgta ctccagcggg tagtacgcgc
    13681 cgccggggat gtcctcatag gcgttccacc aggcggagga gcggttgcgg ctggctgcct
    13741 tggcgatgtg ggtgagttcc tcgcgtagct cgtcgggcgc cgtgtagaag cggcagaggg
    13801 cgtcgatctc cgggccgctg aggcgcttcc acttcccgtt ctcgatacgg gagaccttgg
    13861 acttgtgcca gcccatctcc tcggcggcct cctcctgcga caggccggtc ctggcacgta
    13921 gtcgcttgag ctggctgatc aggtagtgcc gccgggcggg ggagccctgg accggagtgc
    13981 cctcgggcat ctccacctcc tgtcgtcgct gtgctggcgt tgtcatcttc ccactgacag
    14041 agaagcacgc atcattactc attgtacgca aatcaacttg ctgcacttgt aatttgcgtt
    14101 gttgcaaatc atgatggaca caagcggact gatgccggat gggtgacggg tcctgctgtg
    14161 tcgattcggt atggacgtag gcgaggtggt gctcgatgga cggggtcgtg tgttcctggg
    14221 tgaggccgag gccgaggccg gtggacgtgg gtctggcccg tggtctggtc gaccacgctc
    14281 tggtggcggc cggagtgggg gaggcgggac gtgcagcagc tcggctggcc gtgagtgagg
    14341 cgttcacgaa cgccctcgtg catgggcggc cggaggtggg cgtggaggtg tggtcgaagc
    14401 ccgggcactg cgccgtgatc gaggtgtacg acaccgaggc cacggtgccg gtcttcccgc
    14461 agacgtggga gttggcggat gcggtggccg agcatggtcg cgggctgggg ctcatccagg
    14521 ccttcactcg cgaggtgtgc ggtgcctatc gctgtggtga gggcaagcgg gtgtggttcg
    14581 cggtggcaca ggacgggggc gagatcgatg ccgacgccgt tcggtgcctg gtagccgaac
    14641 gtgctcggcg gcgggtgagt ggggtttcgt tcacggctgc ttgacctcgg tcaccgccgc
    14701 catgggaagc gcagctccgg cttcttccgg agccattgac actcatggtg ttccggtctg
    14761 gctggcttga ggcagaggga agagaaggag gagagatggt gagtgaccgc cgtgggaagc
    14821 gccgtaggcg tcaccgggga gcgcgcccgt acctggtccg gcaggacgac cgtgtgagtg
    14881 cggtacgggc tgccttggcg cgtatgccgg ttcgctgggg gccgggggag ctcgaagagt
    14941 tggccggtct cgtgcgcatc tggcaggcgt tccgcgccgg gccgtgttga ggtggatctc
    15001 tactgatctt gcgctccgcc cgtaccgggg agcgcaccag gagcattttc gaggtgccgg
    15061 acacgagaaa accccaggtc gggagcaccg tgaacgtgat ctgacctggg gtttcggtgg
    15121 tagggcccca ggggatcgaa ccctgaaccc gcggattaaa agtccacggg atggtgggcg
    15181 tttcgtgacc tatgtggttg ttcgctctgg cctgttcggg tgcggttgtg ccaccaggga
    15241 ccacgggagg ccaccgccga ccagggggtt ccggagcacc ggagccacaa cggagctaat
    15301 tcgcagttct gcgggagcgc ggtcaaaatc cgctggatgc tcgaggtggg gcgcatatct
    15361 gctcggtagc tctttgcgtg tgttggtctc gccccgaggt cgacgtcttc tgcgacccga
    15421 tccggccgct ccttccctgc gcgcgcgggt ctcacccaag tcgcagaggt actcgagtca
    15481 gccgtgatcg cttcggtctg gccgttggat gtgccgggtc tgccgaaggg gccgcgatca
    15541 cggctgatgg tggaagctga tgcgcatcag ccgactgctg acccagtctt cgagccgagt
    15601 cggccggatg gtgccggggt cgtggggctg attgagatcc gtgacgatct cggccagcac
    15661 ggcctgacgt tcagccgggt cggtgacagg cgtggctcgt gcaggcagat ctgcgcggat
    15721 cccgttcttg aggtggaagg tgaggtcggg attggcgagc aggttcgcgt gccagtcggt
    15781 cgcggcaccg ccagcgccgc tacacaggta ggtggtgtcc gcagctcggt agaagaagat
    15841 ctcgatgcgg cgtggacgac cggtgcggcg gcccagcgtc gtgatgtcga tgatccgctc
    15901 tctggtgccc gcggcggggg tgatctcgat ggctcgtcgg atgtggttgg gcaggtggga
    15961 cagggatgcg tcctgtgcgg agtcgttcga cccggtcgtg tctggagtgc tcatacggtc
    16021 tcgctctgaa gggcggggcc gaggaggagt ccaccatcga tgacgtactc cgatcccgtg
    16081 atgaacgacg cctccgatga ggtgaggaac aggagaagac ggctgacgtc ggtcggctcc
    16141 ccgagtcggg ggatggcgaa cggctcgggt gagtagaagt cggcgatcgc cgcggtcgcg
    16201 ccagcagctg gttcttggat gaagggggtc gcgatcacac cggggtgaat ggtgttcacc
    16261 cggatgtggt cgcgcccgag ctcgagcgct gccgtttggg tgaggcctcg cacagcccac
    16321 ttgctggcga cgtagggcgc gtagtgcgcc gtgccgccca ggcccatggt cgaggcgatg
    16381 ttgacgatgg cccctccggc tgcgcggcgc agagcgggga ctgcgacctt gatgccgagg
    16441 aagatccccg tgaggttgat gtcgaggatc cgcgaccacg tggcctggtc cgtgtgttcg
    16501 atcggtgcgg gcgggttctg cacgcccgcg ttgttgacga gcacgttcac ggcgccgaag
    16561 gcgctctcgg cggccagcac agcggaggcc cacgagccct ggtcggtaac gtcgaggcgg
    16621 acgaagcgag cgcgggttcc gagctcgtcg gccagagcgg cgccgcgttc cgcgtcgatg
    16681 tcgccgatca ccacgttcgc tccctccgcg tgaaaggcgc gcgcgtgact cgctccctgg
    16741 ccgccggtcc caccagtgac gagtacggtc tggttgtcga agcgtggcat cagatgttcc
    16801 ttcgctgcgt gggtgaatga ccgggatcac cagtgatgaa ccggcggcca gtggtgagtc
    16861 gtgcgactca ccattgctct gacactaggt cggcgacagt ggtgagtcaa gccactcacc
    16921 tcgtatgctt ggcccatgag cagagtcgtg acgacgtatc accagcgcgt cgcccaggag
    16981 aagcgcgccc tgatcgtgac ggccgcgacc gcactgtttc tcgagttggg ctacgaccgg
    17041 acgtcgttgg cgcggatcgc agagtcctcg ggcgtttcgc gggctacctt gttcaagcag
    17101 tttccgagca aagccgccct cttcgacgcc atcgtgaccg agtcctggtc gaccgctgac
    17161 gaggaggatc ctccgtcggc aggcaacgtc gttgacgggc tcggcatcat cggtcgccgt
    17221 tacgccgagc tgttgggccg tgcccagatg accgacctgt tcaggatcgt catcgccgag
    17281 ctgccgcggt tccctgagct ggcccatgcg cagttctcgc acgggaagat gccctacttc
    17341 gagtccctac gcagctacct cctggctgag cacgaggcgg gaacggtgcg ggtcgaggac
    17401 gtggacctcg cagccaccca gttcttgggc atgatctcca actatgtctt ctggccgaca
    17461 cttctggtgc cgggctggga ggtgagcgcc gaacgcgtcg ctcaggtagt cgacgaggcc
    17521 gtccgcacca tcgtcgcccg gtactccgcg actgggccag ggccgtcgac caacagctga
    17581 gtcccgccgc cacatccggc gcgaaacacc ttgtccgtgc cctggactag tgcacagtcg
    17641 tagtccactg gctccagcga ggacagggct tcgctgcggg cgccatcgcc catgggaacg
    17701 tgcccccggt gatttcccca cactgacggc cgagccagtg tgggcatggg tggggtggag
    17761 gtggtggcga tggtcaacgg gatgtcggtc tttaagaggt gtgggtgccg ggacgcacgg
    17821 aggaagtctc taggaaaggg ctgcccgaac ctgggacggc gcggacacgg gagctggtac
    17881 ttctcggtgg agctgccgcg tcgtgacggg gtgcggagac gagtccgacg tggagggttt
    17941 gcctcacgtg aggcagccag cacggcagcc tccgcactgg tgagtcctcg ggaggggcag
    18001 gaaactgccc ctcttctcac gagcgtgcag agggtgcggg ccactttgcg agcggcgttg
    18061 aacacggcag tgcgggaggg gcaccttgac gccaatcctg cccaggggtt gaagctgacc
    18121 tcgggcaggc ggccgcgtcc ggtgctgtgg acgcaggacg cccagcgtga gtgggagcgt
    18181 ggtggtgacc gtccggctgt ggcggtgtgg tcggtgcagc acacccgctc ctttttggac
    18241 ttcgtggccg ggcaccggtt gtatgcgctg ttccacttgg tggtgctgct ggggttgcgg
    18301 cgcggtgagg tgctcgggct gcggtggcgc gacgtggacc tagacgcgcg ggtgctgcat
    18361 gtggaaagcc aggtgcagca ggtgggaggg tgcgtggtgg tagctgagcc caagagcgag
    18421 gcgagccgcc gcaccgttgc tctggatcag gtgacggtcc aggtgcttcg tgcccaccgt
    18481 aggaagcagc agagcgagcg gtcgggaacg gggcgtgcgg acccggacct ggtgttcacc
    18541 tgtatcaagg gaggctgcct ggccccggac cggctgagtc gctcgttccg gaagttgaac
    18601 acggagagcg gactgccgcc ggtacggctg cacgatctgc ggcacggtgc ggccacgttc
    18661 gcgctggcgg ccggggtgga cctgaagacg gtgcaggcga tgttggggca cgcgagcatc
    18721 gtgttgaccg cggacacgta cacgagtgtg ctacccgagg tcgctcacga ggcggcggag
    18781 gcgacagcgg cgctagtgct gcgtgatgcc cggtcggcgc gggttcggca ccgtgcgctc
    18841 cgacgtcgaa ggaagcggag gggtggtccc atgcgggccc cacccgggtc ccaccaaggc
    18901 aacgcccgcc ggggttcggc gggcgttatc ccaggtgagc ggtggtaggg ccccagggga
    18961 tcgaaccctg aacccgcgga ttaaaagtcc gctgctctgc caattgagct aaggccccgt
    19021 gtggacgtcc gggcgctgcc ggagtttcac cgggacaact ctaccgcagc gccacaacgg
    19081 tcgtggagcg gtgaacacgc ctgtgggaag aggatccagc ggccccgcgg acgtgggccg
    19141 ggcgcgtcgc cgcacctgcg acggggcatg ttggtgtact cggagagcat cctgagccaa
    19201 ccgacgacaa ggagcatcat ggcgttctcc gagaagcagc aggcggtcct gcgcaaaccc
    19261 gcgttcgggc acgtggcgac cctcggcccg gacggtggac cccagtccag ccccgtgtgg
    19321 atcgactggg acggcgagtt cctcaggttc agccagacca cgacccggca gaagctgcac
    19381 aacctcaagc gcgacggccg gatcgcggtg tcggccgtcg accccgacga cccctacatg
    19441 tacgtggagg tccgcggcgt gtgcgaccgg gtggagaagg acgaggacaa ggccttcatc
    19501 aacgagatgt cccagaagta cctcgggaag ccctacccct gggacgaccc ccaggaggag
    19561 cgcgtcatcg tctacgttcg ccccgagcgc ttcgtgggcc ggtaggcgcg tgtgcggccc
    19621 cgcgccggtg gggccgcacc ggccgccccg gagcatgcgg cttccgtccc gcaaaagtac
    19681 ctgttgagaa agtttgcatg gtctgcaata attggtcgtg cacgggggag gaccattggg
    19741 actgcgcgaa cgcaagaagc aggccacgcg ccgcgcgctc caggacgcgg ccgtgagcct
    19801 caccctggag cgcggtctgg agaacgtgac ggtggaggag atcgcggccg aggccgacgt
    19861 ctccacccgg accttcttca actacttcgc caccaaggag gacgccctcc tcggcgacgt
    19921 tccggagact cccgacgagg aggcacggcg ggagttcgtc ggtggcggac ccaccggcga
    19981 cttcgtcgag gacctcatca ccgtgctgat cacgttcctg gtcagtaccg acgatctcgc
    20041 cacgcagcgc gccgacatgc gcctgcgcag ggaactcatg gaacgcgagc ctcagctcgt
    20101 gcgcggcatg ctcgcccgct tccacaacgt ggaaatggaa ctcgccgcgg ccatcgccga
    20161 gcggaccggc gcctcagccg gggacgaccg tcccctcctg gtcgccgcgt cggccatgtc
    20221 ggtgatgcgc cacaccatga agagcctcca cttctcggag agcgaggaga ccgcggacgt
    20281 ccgcgccaag atccgcgcgg ccttccgtca tctgggcgag gcctacgggc cgtccgcgcc
    20341 caacggctga ccggggcact ccggcccctc ggggcctcct agcaggcgaa cggagtccca
    20401 tgcccaccac ccccagccgc accaggctgc gctggatctt cctggcgatc atcctgacga
    20461 tgctgctggc ctccctggac cagaccatcg tcgcgacggc cctgcccacc atcgtgggtg
    20521 agctcaacgg cctggagcac ctgtcctggg tcgtcaccgc gtacatgctc gcggccaccg
    20581 tcggcatgcc gatctacggc aaggcgggcg acatcttcgg ccgccgccac gtgtacctgt
    20641 tcgcgatcgt ggtcttcctg ctcggttccg tgctgtcggg gctcgcccag gacatgaccc
    20701 agctcatcct cttccgcgcc ctgcagggca tcgggggcgg cggtctgatg atcagcgccc
    20761 aggcgatcat cgccgacgtc gtctccccac gggaacgcgg caagtacatg ggcatcatgg
    20821 gcgccgtgtt cggggtctcc tcgatcgccg gtccgctgct cggcggcttc ttcaccgacc
    20881 agttggactg gcgctggatc ttctacatca acctgcccct gggagcggtc gccctggtcg
    20941 cggcggcgac catgatccgc ctgcccaagc ccgaggggcc caggccgaag ctggattaca
    21001 cgggcaccgt tctcctggcc gccacgagcg tgtgcctggt gctgctgacc agctggggcg
    21061 gccacaccta cgactgggtg agcccgcaga tcctcggact gggggcggcg gcgatcgcgg
    21121 cggcgttcct gttcgtgctg gtggagcggc gtgcggccga gccgatcatc ccgctgcgcc
    21181 tgttccgtga ccgcgacttc gtcctcaccg cgctgatcgg tatcacggtg ggcatcgcga
    21241 tgttctccac ggtctcctac ctgcccacgt tcctgcagat ggtcaagggc gccaccgcga
    21301 ccgagtccgg gctgctcatg ctcccgatgg tgctcggcat gctcatcagc accatcacga
    21361 ccggtcgcct catctccgcc accggccgtt acaagcactg gcccatcatc ggcaccgcca
    21421 tcatcacggt aggcctggtc ctgctctccc ggatggacgc cgacaccccc tacctctaca
    21481 acggctcggc gatgctggtc atgggtctgg gcgtgggcat ggtgatgcag aacctggtgc
    21541 tgatcgtgca gaacacggct ccccggcgcg acctcggtgc cgccacctcg gcgaacaact
    21601 acttccgcca gatcggtgcg tccttcggca tcgccgtgtt cggatcggtc ttcgtgtccc
    21661 gtctcaacga gcggatggcc ggcataccgg gcggaagcct ggagttcgag ggcggtgagg
    21721 ccgggatcag ctccatgacc ccgcagatgc tgcagggcct gcccggcccg gtgcgcgagt
    21781 tcgtcgtgca cgccttcgcc ggtgcgctgc ccccgatctt cctctacgtg gttccgatcg
    21841 ccctggtcgg attcgcgctc tcctggttca tcaccgagaa gccgctggcc accaccgtcg
    21901 gcggcacgga gcagggcaag gagagcacgg agggagcgga gagcggcccc cgtgagggga
    21961 gggacgtcag gggcggggac gtcagggact ccgtgtaggg ggcggctccc accgcgcggg
    22021 cgcatggacc caccgcacgg gcgcggggct cccgccggcc ggggaggccg tgccccatga
    22081 tgtgtcccac gcctcaggaa cgccttcgcc tcctcggccg tccaacctcc caggggtgcc
    22141 cgggcatccc gtatccgggc ccctccaggg ggctcggggg gatgtcaggg gaggcccagg
    22201 gctgtccccg atgggaatcg tcgtgggaag ggggcaagct ggagacatga acgagagcta
    22261 ccagaacaag cgcttccgac gcagtggttc cgaccggtac ctggccggcg tgtgcggc
//
