LOCUS       NZ_MCOK01000001        21083 bp    DNA     linear   CON 22-OCT-2024
DEFINITION  Nocardiopsis sinuspersici strain UTMC 00102 NOSIN_1, whole genome
            shotgun sequence.
ACCESSION   NZ_MCOK01000001
VERSION     NZ_MCOK01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Nocardiopsis sinuspersici
  ORGANISM  Nocardiopsis sinuspersici
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsidaceae; Nocardiopsis.
REFERENCE   1  (bases 1 to 6071583)
  AUTHORS   Tokovenko,B. and Kalinowski,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-AUG-2016) Helmholtz Institute for Pharmaceutical
            Research Saarland, Helmholtz Centre for Infection Research, Campus
            C2.3, Saarbrucken 66123, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 20-JUL-2016
            Assembly Method                   :: SPAdes v. 3.8.1
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 106.0x
            Sequencing Technology :: Illumina NextSeq; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001998325.1-RS_2024_10_22
            Annotation Date                   :: 10/22/2024 13:01:47
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,351
            CDSs (total)                      :: 5,274
            Genes (coding)                    :: 5,224
            CDSs (with protein)               :: 5,224
            Genes (RNA)                       :: 77
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 50
            CDSs (without protein)            :: 50
            Pseudo Genes (ambiguous residues) :: 0 of 50
            Pseudo Genes (frameshifted)       :: 13 of 50
            Pseudo Genes (incomplete)         :: 44 of 50
            Pseudo Genes (internal stop)      :: 2 of 50
            Pseudo Genes (multiple problems)  :: 7 of 50
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 18:06:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3164211
            Orig. end                         :: 3185294
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            MCOK01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21083
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="7"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21083
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21083
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11083](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11083
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(496..510)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.77"
                     /tool="antismash"
     misc_feature    complement(1778..1792)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     gene            complement(2691..3833)
                     /gene="carA"
                     /locus_tag="NOSIN_RS13590"
                     /old_locus_tag="NOSIN_13425"
     CDS             complement(2691..3833)
                     /EC_number="6.3.5.5"
                     /GO_function="GO:0004088 - carbamoyl-phosphate synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006207 - 'de novo' pyrimidine nucleobase
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0006541 - glutamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="carA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1249: carbamoyl phosphate synthase small subunit"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017590402.1"
                     /locus_tag="NOSIN_RS13590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_13425"
                     /product="glutamine-hydrolyzing carbamoyl-phosphate
                     synthase small subunit"
                     /protein_id="WP_077693580.1"
                     /transl_table=11
                     /translation="MSETTGGPAILVLEDGRVFHGRSFGATGETFGEAVFNTGMTGYQE
                     TLTDPSYHRQIVVMTAPHIGNTGVNDDDPESGRVWVAGYVVREPARITSNWRAQRTLDE
                     ELRHQDVVGIALTGTRALTRHLRDKGAMRAAISTTETDPKALLARVREQPSMAGSELAA
                     EVSTREPYEVLPPEGVETRFHVAAVDLGIKAMTPQRLAERGCRVTVLPAAATAEDILAL
                     DPDGVFFSNGPGDPATADGPVAAMRGVMDAGRPLFGICFGNQILGRALDLGTYKLPFGH
                     RGVNQPVIDTRSGRVAVTSQNHGFAVDAPIGTPFDTPYGRAEVSHVGLNDQVVEGLRLL
                     DRPAFSVQFHPEAAAGPHDAAELFDAFVDLMSAQPASAVK"
     gene            complement(3884..5185)
                     /locus_tag="NOSIN_RS13595"
                     /old_locus_tag="NOSIN_13430"
     CDS             complement(3884..5185)
                     /EC_number="3.5.2.3"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017565062.1"
                     /locus_tag="NOSIN_RS13595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_13430"
                     /product="dihydroorotase"
                     /protein_id="WP_077691095.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 1.9e-16, bitscore:
                     58.5, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDTNGPHLIRGASPLGGAPVDLLLADGRIAAIGPGLDAPADAET
                     VDASGLVALPGLVDLHTHLREPGREDAETVATGSRSAAMGGYTAVHAMANTDPVADTAG
                     VVEQVWRLGREGGYCDVRPVGAVTVGLAGRQLSEIGAMADSAAKVRVFSDDGVCVSDAL
                     LMRRALEYVKAFDGVVAQHAQEPRLTQGAQMNEGRVSDRLGLPGWPAVAEEAIIARDCL
                     LAQHVGSRLHVCHVSTKGSVDIIRWAKARGCDVTAEVTPHHLLLTEELVEGYDPVYKVN
                     PPLRTAEDVQALREGLADGTIDIVATDHAPHPVEAKETEWSTAAMGMVGLETALAVVQR
                     TMVDTGLLTWADVADRMSAAPARVGRVHEHGRGLAAGEPANVVLYDPAAPVEVDGAAMV
                     TKSSNTPFRGMTLPGRVRATFLRGAPTVLEGKIQ"
     gene            complement(5406..6314)
                     /locus_tag="NOSIN_RS13600"
                     /old_locus_tag="NOSIN_13435"
     CDS             complement(5406..6314)
                     /EC_number="2.1.3.2"
                     /GO_function="GO:0004070 - aspartate carbamoyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0016597 - amino acid binding [Evidence
                     IEA]"
                     /GO_process="GO:0006207 - 'de novo' pyrimidine nucleobase
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1114: ornithine carbamoyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014913461.1"
                     /locus_tag="NOSIN_RS13600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_13435"
                     /product="aspartate carbamoyltransferase catalytic subunit"
                     /protein_id="WP_077691096.1"
                     /transl_table=11
                     /translation="MRHLLSTGDLSHDEATLILDTAAELAQVGDRSVKKLPTLRGRTVV
                     NLFYEDSTRTRTSFELAAKRLSADVVNFSAKGSSVSKGESLKDTALTLQAMGADGVVIR
                     HSASGAAHRLANWVDGSVLNAGDGTHEHPTQALLDAFTMRSRLGRLEGLRVAVVGDILH
                     SRVARSNVLLLTTLGAHVTLVAPPTLLPVSVHTWPCEVSYDLDAVLPKSDVVMMLRVQA
                     ERMHESFFPSTREYSRNYGLDGERLSRMPEDAIVMHPGPMVRGMEISAEVADSPRCTVT
                     EQVANGVSLRMAVLYLLLSGS"
     gene            complement(6314..6994)
                     /gene="pyrR"
                     /locus_tag="NOSIN_RS13605"
                     /old_locus_tag="NOSIN_13440"
     CDS             complement(6314..6994)
                     /EC_number="2.4.2.9"
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pyrR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291500.1"
                     /locus_tag="NOSIN_RS13605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_13440"
                     /product="bifunctional pyr operon transcriptional
                     regulator/uracil phosphoribosyltransferase PyrR"
                     /protein_id="WP_170293694.1"
                     /transl_table=11
                     /translation="MPEGTRAVLEGNEINRALTRIAHEVLERTKGGQDVTLLGIPSRGV
                     PLARRLARLIERVEDRTVPAGSLDITMYRDDLRSAPVRALGRTEIPVGGLDDRVVVLVD
                     DVLFSGRTVRAALDALGDLGRPRAVQLAVLVDRGHRELPIRADYVGKNLPTSLRESVTV
                     RLDETDGYDAVLLGPARPSPSTTLNRRPAAEEPPSSSPSTTLNRRPAAEEPPSSSPSTT
                     GGND"
     misc_feature    complement(7170..7185)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     misc_feature    7421..7439
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.1"
                     /tool="antismash"
     gene            7553..8047
                     /locus_tag="NOSIN_RS13610"
                     /old_locus_tag="NOSIN_13445"
     CDS             7553..8047
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017622275.1"
                     /locus_tag="NOSIN_RS13610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_13445"
                     /product="transcriptional regulator"
                     /protein_id="WP_077691097.1"
                     /transl_table=11
                     /translation="MPSEYAKSLGARLRAIRTQQGLSLHGVEEKSHGRWKAVVVGSYER
                     GDRAVTVQKLAELADFYGVPMSELLPGGAAPTPLGPTPKLVIDLERMQQLPHEKAGPLS
                     RYVATIQSQRGDYNGRVLSIRQEDLRSLAVIYDKSPGDLTEELINWGVLDPEARRAVDA
                     F"
     misc_feature    8242..8257
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: strong, score: 26.96"
                     /tool="antismash"
     misc_feature    complement(8243..8256)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.75"
                     /tool="antismash"
     misc_feature    complement(8253..8266)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.86"
                     /tool="antismash"
     gene            8368..8982
                     /locus_tag="NOSIN_RS13615"
                     /old_locus_tag="NOSIN_13450"
     CDS             8368..8982
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017576792.1"
                     /locus_tag="NOSIN_RS13615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_13450"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_170293692.1"
                     /transl_table=11
                     /translation="MDADTELRELAPPAFTHAVPALLQVYEAAMRPPPEQLPGRASVMN
                     NHAGHPGFRAVVAVRGGHPVGFAYAFHGCSGQWWHDTVVRELHACGRTRQVRRYLSDPL
                     EIAEVHVHPRAQGRGVGRSLLHALCRGRPEPTAVLSTRSGPSVARHLYRSCGFTEVLED
                     FSFPGSPGQPFSIMAARLPLAGSGDRRSPDRSAWWPWTGSR"
     misc_feature    8372..8387
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 23.54"
                     /tool="antismash"
     gene            complement(8894..9823)
                     /gene="metF"
                     /locus_tag="NOSIN_RS13620"
                     /old_locus_tag="NOSIN_13455"
     CDS             complement(8894..9823)
                     /EC_number="1.5.1.20"
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="metF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014912167.1"
                     /locus_tag="NOSIN_RS13620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_13455"
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="WP_077693582.1"
                     /transl_table=11
                     /translation="MAPRNPAPRPRHIRELLDAGEPMFSFEFFPPRTPRAQERLWRAIR
                     EIEALGPSFVSVTYGAGGSTRGMTVETTERIATDTTLLPVAHMTLVDHSVAELRHLVGR
                     LADAGVSNMLAVRGDPPGDPNGEWVTHPEGLTYAEELVRLIKDSGDFCVGVAAFPFKHP
                     RSADVETDTDYFVRKCEAGADYAITQMFFDPEDYLRLRDRVAARGCEVPIIPEVFPVVR
                     TSFIPRSEQLSGAPFPRDLAERFESFGDDAEAVRAFGIEYAQRMCERLLAEGAPGIHFI
                     TSNQSTATRQIYREIAGHRSRPEAAGRP"
     gene            10001..11083
                     /locus_tag="NOSIN_RS13625"
                     /old_locus_tag="NOSIN_13460"
     CDS             10001..11083
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017535128.1"
                     /locus_tag="NOSIN_RS13625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_13460"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_077691098.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.6e-45, bitscore:
                     153.6, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVPSSSPSASPVSVIRSDVDHELSGFSAAHRAQVLEIGEELAPAM
                     DALEAMLSGGKRLRPTFCYWGWRGAGGAADDERVVRAAASLEFLQACALVHDDVIDNSD
                     TRRGMPATHKRLAKLHADHGWSGDSEGFGMGAAILIGDLCLVWSDEMYQASGFPAEVLR
                     DGRPPFDAMRTEVMAGQYLDTLEQVRGTATREAALRVMRYKSAKYTVERPLHLGAALAG
                     RHEELAGVYTAYGIPLGIAFQLRDDVLGVFGDPSTTGKPAGDDLREGKRTLVVAETLAR
                     VGAADAERFRSLLGAPDLSVESVGWMRSLIEESGALMVCEKMIGEYADEAVRALESPEL
                     DADAREPLRRLVVAATSRSH"
     misc_feature    complement(11139..11154)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 21.53"
                     /tool="antismash"
     misc_feature    complement(11207..11220)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.21"
                     /tool="antismash"
     gene            11247..12527
                     /locus_tag="NOSIN_RS13630"
                     /old_locus_tag="NOSIN_13465"
     CDS             11247..12527
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017581724.1"
                     /locus_tag="NOSIN_RS13630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_13465"
                     /product="DUF418 domain-containing protein"
                     /protein_id="WP_077691099.1"
                     /transl_table=11
                     /translation="MPGHAVARGPAGAGERALAPDLARGSMLLFIAIANTAWYLWAVPM
                     SGMSAHPEPAGALDAVAQFFTVMAVDSRSYPMFAFLFGYGMVQLARRQEAAGTSARDVD
                     ALLRRRNLWLLVFGFVHALLLWMGDVLGAYGLAGLVLGWLFLRRADRTLLVWAGAITGL
                     MLLLSAFSLVGLAFTPADGAASPAPGLEQLAANIGEPSLWGAALGRLTAWPLVVLGQGL
                     LGLAVPTAILLGYWAARHRILEEPGNNLALLRLTAFAGVTVGWLGGLPSALAQVGVWEL
                     SPTQASMLSMPHMVTGLACGLGYVSLIALAARRLQERGRGSGPVVEALAATGKRSLSAY
                     LAQSVLCAPVLAAWGLGVGAHLTSWSMFLFAVGVWLVTVVAAHALERAGRRGPAEVLLR
                     RLAYRGPVAGGAREPEEGPVGGRDPKA"
     gene            12584..13477
                     /locus_tag="NOSIN_RS13635"
                     /old_locus_tag="NOSIN_13470"
     CDS             12584..13477
                     /EC_number="1.6.5.2"
                     /GO_function="GO:0016655 - oxidoreductase activity, acting
                     on NAD(P)H, quinone or similar compound as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013154128.1"
                     /locus_tag="NOSIN_RS13635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_13470"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_077691100.1"
                     /transl_table=11
                     /translation="MGDDHMTNHTIGVTGATGALGGRVAARIARLGMSQRLIVRDINRA
                     PEYPGSSAAMAAYEDTEAFERACRGVDTLFLVSATESEDRVDVHLSAVDGAIKAGVSRI
                     VYLSFLRAGPAATFTFARTHFFTEAHIRSTGVRHTFLRPSLYLDLLPDWVDHGGVVRGP
                     AGEGRVAWVSRDDVADVATAVLTDPMTTLSSDNATYDVTGPEALSLGAAVDRLSTLTGR
                     PVRYVPETREEALESRRGGGAPDWAVEGWVSSYEAIASGELDVVAPTVPELTGHPAQSI
                     EGFLRRHPSALSHVAV"
     gene            13637..14644
                     /locus_tag="NOSIN_RS13640"
                     /old_locus_tag="NOSIN_13475"
     CDS             13637..14644
                     /NRPS_PKS="Domain: PKS_ER (17-333). E-value: 9.5e-31.
                     Score: 99.0. Matches aSDomain:
                     nrpspksdomains_NOSIN_RS13640_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017565071.1"
                     /locus_tag="NOSIN_RS13640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_13475"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_077691101.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.3e-23, bitscore:
                     81.7, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAVVVDGFGGPEVLVAREVSEPEVGPGRVLVEVGASNVMYLDTL
                     VRSGWGGEYFPVSPPYVPGAGVVGRVAALGEDVDPGWTDALVVTDTGHTDASEGRTTLP
                     VDGYAERAAVPESALVRVPEGVDPKAALALLHDGPTALALERAAAFGPGSTVLVAAATG
                     GAGSLAVQLARAAGARVLAAARGEAKLALARELGAHEAVDYSRPGWEKRVLELTGGTGV
                     DVVLDGAGSALGEAAFGAVADGGRFIGYGTAGGRFSEVDTEEAGRRGVEVLGLFDLQAQ
                     DPDDRRSALRYMLELTRRGEITPHVGLALPLEQASRAHAALEGRTVLGKVLLVS"
     aSDomain        13688..14635
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NOSIN_RS13640_PKS_ER.1"
                     /evalue="9.50E-31"
                     /label="NOSIN_RS13640_PKS_ER.1"
                     /locus_tag="NOSIN_RS13640"
                     /protein_end="333"
                     /protein_start="17"
                     /score="99.0"
                     /tool="antismash"
                     /translation="REVSEPEVGPGRVLVEVGASNVMYLDTLVRSGWGGEYFPVSPPYV
                     PGAGVVGRVAALGEDVDPGWTDALVVTDTGHTDASEGRTTLPVDGYAERAAVPESALVR
                     VPEGVDPKAALALLHDGPTALALERAAAFGPGSTVLVAAATGGAGSLAVQLARAAGARV
                     LAAARGEAKLALARELGAHEAVDYSRPGWEKRVLELTGGTGVDVVLDGAGSALGEAAFG
                     AVADGGRFIGYGTAGGRFSEVDTEEAGRRGVEVLGLFDLQAQDPDDRRSALRYMLELTR
                     RGEITPHVGLALPLEQASRAHAALEGRTVLGKVLL"
     CDS_motif       13721..13753
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NOSIN_RS13640_0001"
                     /evalue="2.30E+01"
                     /label="PKSI-ER_m5"
                     /locus_tag="NOSIN_RS13640"
                     /protein_end="39"
                     /protein_start="28"
                     /score="-1.8"
                     /tool="antismash"
                     /translation="RVLVEVGASNV"
     CDS_motif       14093..14155
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NOSIN_RS13640_0002"
                     /evalue="1.90E-04"
                     /label="PKSI-ER_m5"
                     /locus_tag="NOSIN_RS13640"
                     /protein_end="173"
                     /protein_start="152"
                     /score="14.1"
                     /tool="antismash"
                     /translation="GSTVLVAAATGGAGSLAVQLA"
     CDS_motif       14285..14314
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NOSIN_RS13640_0003"
                     /evalue="6.20E-03"
                     /label="PKSI-ER_m7"
                     /locus_tag="NOSIN_RS13640"
                     /protein_end="226"
                     /protein_start="216"
                     /score="9.5"
                     /tool="antismash"
                     /translation="TGGTGVDVVL"
     CDS_motif       14432..14452
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NOSIN_RS13640_0004"
                     /evalue="2.80E+01"
                     /label="PKSI-ER_m7"
                     /locus_tag="NOSIN_RS13640"
                     /protein_end="272"
                     /protein_start="265"
                     /score="-1.5"
                     /tool="antismash"
                     /translation="GRRGVEV"
     gene            complement(14667..15341)
                     /gene="thiE"
                     /locus_tag="NOSIN_RS13645"
                     /old_locus_tag="NOSIN_13480"
     CDS             complement(14667..15341)
                     /EC_number="2.5.1.3"
                     /GO_function="GO:0004789 - thiamine-phosphate
                     diphosphorylase activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1280: thiamine-phosphate pyrophosphorylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017565072.1"
                     /locus_tag="NOSIN_RS13645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_13480"
                     /product="thiamine phosphate synthase"
                     /protein_id="WP_077691102.1"
                     /transl_table=11
                     /translation="MRTSHGTSLRKRLDTSLLYLCTDARTGRGDLAEFADAALAGGVDI
                     IQLRDKGLEAREEIAALEVMQDACERHGALLAVNDRADIARAVRADVLHLGQRDLPVPM
                     ARDIIGADPLIGRSNNDADAAAASAEDPGSDYFCVGPTWATPTKPGRPAAGLDLVRRAA
                     ALGADRPWFAIGGIDADNIDQVLDAGARRVVVVRAITEAPDPRAAAAELRRRLTARTPG
                     QG"
     gene            complement(15651..16028)
                     /locus_tag="NOSIN_RS13650"
                     /old_locus_tag="NOSIN_13485"
     CDS             complement(15651..16028)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017546549.1"
                     /locus_tag="NOSIN_RS13650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_13485"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_171986593.1"
                     /transl_table=11
                     /translation="MWQIGAVTQSDMDIDALVGEWLTLKEAAQPLGVSPNRIKTLIREN
                     RLMGVVRGGELSIPAAFVDGHDLVKGLPGTVMLLSDAGFSTEEALRWLFTPDDSLPGTP
                     IQAMRENRGTEVRRRAQSMAF"
     regulatory      16154..16265
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(16222..16235)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     gene            16234..17505
                     /gene="thiO"
                     /locus_tag="NOSIN_RS13655"
                     /old_locus_tag="NOSIN_13490"
     CDS             16234..17505
                     /EC_number="1.4.3.19"
                     /GO_function="GO:0016647 - oxidoreductase activity, acting
                     on the CH-NH group of donors, oxygen as acceptor [Evidence
                     IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene="thiO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014911304.1"
                     /locus_tag="NOSIN_RS13655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_13490"
                     /product="glycine oxidase ThiO"
                     /protein_id="WP_150285718.1"
                     /sec_met_domain="DAO (E-value: 2.4e-59, bitscore: 199.9,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAKGGETSAVRTSNTPRSPMGHPTDGRAGDRGVVVVGGGLVGRV
                     TAWRAAQRGLSVTLVEPDPVADPAGARAASTVAAGMLTPATEAVFGEEPLMELGVRSAA
                     MYADFVTELEEASGLGVGHRATGTLLVAFDRDDLAVLTELHELHQRLGIATERLTSRGC
                     RRLEPMLAPSVRGGLLAPDDHSVDPRRLLRALAVAGERAGVTEIAGRAEEVLAPGPDGT
                     RLGVRLDDGRLLPADQAVLAAGCWGDAVGVPEPVVPPLRPVKGQLLRARVPAGEPPIVG
                     RTVRGLVRGFPTYLVPRADGEVVIGATQEELGHDTSLTAGGLWQVLRDARELVPGVSEL
                     EITETCVGLRPGSPDNEPLLGPTRVPGLHLAAGHFRHGVLLTPVTGEVMARALTTGVLP
                     EYAQRFAADRVFGGGGTTKRKQWE"
     misc_feature    17507..17522
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.87"
                     /tool="antismash"
     gene            17508..17723
                     /gene="thiS"
                     /locus_tag="NOSIN_RS13660"
                     /old_locus_tag="NOSIN_13495"
     CDS             17508..17723
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017565075.1"
                     /locus_tag="NOSIN_RS13660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_13495"
                     /product="sulfur carrier protein ThiS"
                     /protein_id="WP_077691105.1"
                     /transl_table=11
                     /translation="MELIINGDRREVTDDTTVEAVVRDLTAAANGEIPGGIAVAVNDEV
                     VRRAAWSDNALGAGDRVDVLTAVQGG"
     misc_feature    complement(17509..17523)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.26"
                     /tool="antismash"
     gene            17726..18505
                     /locus_tag="NOSIN_RS13665"
                     /old_locus_tag="NOSIN_13500"
     CDS             17726..18505
                     /EC_number="2.8.1.10"
                     /GO_function="GO:1990107 - thiazole synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017617057.1"
                     /locus_tag="NOSIN_RS13665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_13500"
                     /product="thiazole synthase"
                     /protein_id="WP_077691106.1"
                     /transl_table=11
                     /translation="MAEYTARADDPLVIAGTAFGSRLITGTGGAPSLEVLEEALVTSGT
                     ELTTVAMRRVSPATQGSVWDILTRNKIRALPNTAGCFTAADAVRTARLGREALGTDWVK
                     LEVVADEHTLLPDPVELLEAAEQLVDEGFVVLPYTNDDPVLARRLEQLGCAAVMPLAAP
                     IGSGLGIRNPHNLELIVEQAGVPVIVDAGIGTASDAALAMELGCDAVLLATAVTRAQEP
                     VRMAAAMRDAVRAGRGARLAGRIPVRRHAQASSPGID"
     misc_feature    complement(18572..18586)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.19"
                     /tool="antismash"
     misc_feature    complement(18732..18751)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.35"
                     /tool="antismash"
     misc_feature    complement(18760..18775)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.55"
                     /tool="antismash"
     gene            18979..20964
                     /gene="pknB"
                     /locus_tag="NOSIN_RS13670"
                     /old_locus_tag="NOSIN_13505"
     CDS             18979..20964
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014911144.1"
                     /locus_tag="NOSIN_RS13670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_13505"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_077691107.1"
                     /sec_met_domain="Pkinase (E-value: 3.1e-51, bitscore:
                     172.5, seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 4.5e-07, bitscore: 28.3,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDMTTSDPLVGTTLDRRYFVESRIAGGGMATVYVAHDLRLDRRLA
                     LKVMHPSLAQDPTFVQRFINEAHSVAKLSHPNVVQVFDQGEDQGHVFLAMEYVPGRTLR
                     DLLKAQGRLAPRDALNVMASVLAALGAAHQAGMVHRDVKPENVLITEDGRVKVADFGLA
                     RAVEQSNQGLTRTGTLMGTAAYLAPEQIERGTADARSDVYAAGIMLYELLTGGQPHTGE
                     TPIAIAYQHVNEDVPRPSHFLPGLPPEVDGLVTKATERDPRYRLGNAGQYLAKVLEVLN
                     VLPASSTAGRAPLTPVTPTAATSSVTAPQLIAGGAGPGTENATMIVDMNSAGLDGDGYD
                     GYDDDDGYDDYRSGPDDRRRRNLLIGIGAAVLAVIVLGSGWWFLSGRYADVPDVVGSAP
                     EAARELIRSEGLVYVLSDETVYSDVEAGAVAETDPAAGESLSPDAEVTVHLSKGPQKVS
                     MPDLEGEDSANALKQMEDLGFAPENVVQKEVDAEDVEPGTVVSTDPAAGEEADREGTVT
                     ISVSRSISVPPVVGQDLEGARTALQDLGLTVEVVEQESEDVAEGKVIQQSPDSGAGVGA
                     GDTVTLTVSTGPPGVAIPDVVDMKVKDARKALEEAGFKVKVEKLFGGDVVTHQSHTGKA
                     PKKTEITITATPGGIDLGDFGDRGDD"
ORIGIN
        1 cgacgggcag gtcgcctccg tcgccgtcgg cgggcagcat gccctcctcc cgcagctcgg
       61 cgatggtgga cccggccatg acgcgggcgg cggccttggc cagcggcacc gcggtggcct
      121 tggacacgaa cggcacggtg cgcgaggcgc gcgggttggc ctccagcacg ttgagcacgc
      181 cggaggcgag cgcgtactgg acgttgatca gtccgcgcac cccggtgccc cgggcgatgg
      241 cctcggtgga gtagcggatg cgctcgatgt cctcgcggcc cagggtgatg gagggcaggg
      301 tgcacgccga gtcgcccgag tggatcccgg cctcctcgat gtgctccatg acgccgccca
      361 ggtacaggtc gcggccgtcg tagagggcgt cgacgtcgat ctcgatggcg tcgtcgagga
      421 agcggtcgat cagcaccggg tgctcggggc tgacctcggc gttgcgctcg atgtagtcgg
      481 cgagcatcgt ctcgctgtag acgatctcca tgccccggcc gcccagcacg taggaggggc
      541 ggaccatgac ggggtagccg atctcgtcgg cgacgatcct ggcctcggcg aaggagtggg
      601 cggtgccgta cttgggcgcg ggcagcccgg cgtcgtccag gaccttgccg aacgcgccgc
      661 ggtcctcggc caggtcgatg gcctcggggc tggtgccgat gatgggcacc ccggcctcct
      721 tgaggcggcg ggccaggccc agcggggtct ggccgcccag ctgcacgatg accccggcga
      781 ccgtgccgct gagctgctcg gcgcgcacga cctccagcac gtcctccagg gtgagcggct
      841 cgaagtagag ccggtcgctg gtgtcgtagt cggtggagac ggtctcgggg ttgcagttga
      901 ccatcacggt ctcgtacccg gcgtcggaga gcgcgaagga ggcgtggacg caggagtagt
      961 cgaactccac gccctggccg atgcggttgg gtcccgagcc caggatgatg atcttgggct
     1021 tgtcgcccgg ggggacctcg gtctcctcgt cgtagctgga gtacaggtag ggcgtgcggg
     1081 cctcgaactc ggcggcgcag gtgtccacgg tcaggtagac ggggtggatg tccatggcgt
     1141 ggcgcagttc gcggaccacg tcctcgctct tgccggtgat ctcgccgatc tggacgtcgg
     1201 agaagcccag ccccttggcc tcgcgcagca ggtcggcgtc gagcttgggc gcgtcggcca
     1261 ggacgcgggc cgtctcctcc aggcgcagca tctggtccag gaaccacggg tcgatcctcg
     1321 tcgactcgtg gatctcctcg acggtggccc cggcgcgcag ggcctgctgg acctggcgca
     1381 gccggtgctc ggtgggggtg gcggccctgc ggagcaggtc gtccttgtca ccgggctcgc
     1441 ccgcccaggt caggccgatg cccttcttct ccagggagcg catggccttc tggagcgcct
     1501 cggggaagga ccggccgatg gccatggcct cgcccaccga cttcatggtg gtggtgaggg
     1561 tggggtcggc gcccgggaac ttctcgaagg cgaaccgggg gaccttgacg accacgtagt
     1621 ccagcgtggg ctcgaagctg gccggtgtct cccgggtgat gtcgttgggg atctcgtcga
     1681 gcgtgtagcc gacggcgagc ttggcggcga tcttggcgat cgggaagccg gtggccttgg
     1741 aggccagcgc cgaggagcgg gacacacgcg ggttcatctc gatgacgatg atccggccgg
     1801 tggtggggtg gaccgcgaac tggatgttgc agccgccggt gtccactccg accgcgcgga
     1861 tgaccgcgat accgatgtcg cgcagcttct ggtactcgcg gtcggtgagg gtcatggcgg
     1921 gggcgacggt gatggagtcg ccggtgtgca cgcccatggg gtcgaggttc tcgatggagc
     1981 acacgaccac gacgttgtcg ttgacgtcgc gcatcagctc cagctcgtac tccttccagc
     2041 cgaggatgga ctcctccagg agcacctcgg tggtcgggga gagcgtcagc ccctgtccgg
     2101 ccatacgccg tagctcggtc tcgttgtgcg cgaagcccga gccggcgccg cccatggtga
     2161 aggaggggcg tacgacgacg gggtagccga gctcctcggc ggcggccagg cactcgtcga
     2221 gggtgtggca gatgcgcgag cgggcggact cgccgccgat gcgctccacg atgcccttga
     2281 agctctcgcg gtcctctccg gactggatgg cctcgacgtt ggcaccgatg agctcgacgc
     2341 cgtacttgtc caggatgcct gactcgtgca ggtcgatggc ggcgttgagc gcggtctgcc
     2401 cgcccagggt gggcaggagc gcgtcggggc gctccttggc gatgatcttc tcgatcatct
     2461 cggtggtgat cggctcgacg taggtggcgt cggccatctc cgggtcggtc atgatcgtgg
     2521 ccgggttgga gttgaccagg atgacccgga ggccctcggc ccgcaggacg cggcaggcct
     2581 gggttcccga gtagtcgaac tcggccgcct gcccgatcac gatcggaccg gagccgatca
     2641 cgaggacgga tgaaagatca ctacggcgcg gcatgctctg ttccctcttg ctacttgaca
     2701 gccgaagcgg gctgggcgga catcaggtcg acgaacgcgt cgaagagctc ggcggcgtcg
     2761 tgggggccgg cggcggcctc ggggtggaac tggacgctga acgcggggcg gtccagcagc
     2821 cgcaggccct cgacgacctg gtcgttgagg ccgacgtggc tcacctcggc ccggccgtag
     2881 ggggtgtcga agggcgtgcc gatgggggcg tcgacggcga agccgtggtt ctggctggtg
     2941 acggcgaccc ggccggagcg ggtgtcgatc accggctggt tgacgccccg gtgcccgaag
     3001 ggcagcttgt aggtgcccag gtccagggcg cggcccagga tctggttgcc gaagcagatg
     3061 ccgaagagcg gcctacccgc gtccatgacg ccgcgcatcg cggcgacggg gccgtcggcg
     3121 gtggccgggt cgccggggcc gttgctgaag aacaccccgt ccgggtccag cgcgaggatg
     3181 tcctcggcgg tggccgcggc gggcagcacg gtgaccctgc atccgcgctc ggccaggcgc
     3241 tggggcgtca tggccttgat gccgaggtcg accgcggcga cgtggaagcg ggtctcgacg
     3301 ccctcgggcg gcaggacctc gtagggctcc cgggtgctga cctcggcggc cagctcggag
     3361 ccggccatgg acggctgctc gcgcacgcgg gccaacaggg ccttcgggtc ggtctcggtg
     3421 gtgctgatgg cggcgcgcat ggcgcccttg tcgcgcaggt gccgggtcag ggcacgggtg
     3481 ccggtgaggg cgatgccgac cacgtcctgg tggcgcagct cctcgtccag ggtgcgctgg
     3541 gcgcgccagt tggaggtgat gcgtgcgggc tcgcgcacga cgtacccggc gacccagacg
     3601 cggccggact cggggtcgtc gtcgttgacg ccggtgttgc cgatgtgcgg ggcggtcatc
     3661 accacgatct gacggtggta ggagggatcg gtgagggtct cctggtagcc ggtcatgccg
     3721 gtgttgaaga ccgcctcgcc gaaggtctcg ccggtggcac cgaaggagcg gccgtggaag
     3781 accctgccgt cctcgagtac cagaatcgcc ggtccgccgg ttgtctcgga cacgttcgcc
     3841 ccctcctcca cgccagggct ggcctggtct ttcgatgctg tgctcactgg atcttcccct
     3901 ccaggacggt cggggcaccg cgcaggaacg tggcgcgtac ccggccgggc agggtcatgc
     3961 cccggaaggg ggtgttgctg ctcttggtga ccatggccgc cccgtcgacc tccacgggcg
     4021 cggccgggtc gtacaggacc acgttggcgg gctcgccggc ggcgagaccg cggccgtgct
     4081 cgtggacacg gcccacacgt gccggggccg cggacatgcg gtcggcgacg tcggcccagg
     4141 tgagcagccc tgtgtcgacc atggtgcgct gcacgacggc caacgcggtc tccaacccga
     4201 ccattcccat cgcggcggtg gaccactcgg tctccttggc ctccacgggg tggggcgcgt
     4261 ggtcggtggc gacgatgtcg atcgtgccgt cggccagtcc ctcacgcagc gcctggacgt
     4321 cctcggcggt gcgcaggggc gggttgacct tgtagacggg gtcgtagccc tccaccagct
     4381 cctccgtcag gagcaggtgg tggggggtga cctcggcggt gacgtcgcag ccgcgggcct
     4441 tggcccagcg gatgatgtcc accgacccct tggtggagac gtggcacacg tgcaggcgcg
     4501 agcccacgtg ctgggcgagc aggcagtcgc gggcgatgat cgcctcctcg gcgaccgcgg
     4561 gccacccggg aaggccgagg cggtcggaga cgcggccctc gttcatctgg gcgccctggg
     4621 tcaggcgggg ctcctgggcg tgctgggcga cgacgccgtc gaaggccttg acgtactcca
     4681 gggcgcggcg catgagcagg gcgtcggaga cgcagacgcc gtcgtcggag aagacgcgga
     4741 ccttcgcggc ggagtcggcc atggcgccga tctcggagag ctgccgtccg gccaggccga
     4801 cggtgacggc gccgacgggg cgcacgtcgc agtacccgcc ctcgcggccc aggcgccaga
     4861 cctgctcgac gaccccggcg gtgtcggcga cggggtcggt gttggccatg gcgtggacgg
     4921 cggtgtagcc gcccatggcg gcggaccggg agccggtggc gacggtctcg gcgtcctcac
     4981 ggccgggttc gcgcaggtgg gtgtgcaggt ccaccaggcc tggcagggcg accaggccgg
     5041 aggcgtcgac ggtctcggcg tcggcggggg cgtcgaggcc cgggccgatc gcggcgatcc
     5101 tgccgtcggc caggagcagg tcgacggggg cgccgccgag agggctggcg ccgcggatca
     5161 ggtgcggtcc gttggtgtcg ggcatcgcgg tgttggcttc ctcgtgttct cggttgggaa
     5221 gggttcgtgg gcgccggagc gcggctgggc ggctggtggg tccgggcgcc gccggggccg
     5281 ccggagggtc cgtgggtggg accgcgggga gggccgcgcc gcctcaccgg agggctccgg
     5341 gggttcccgg cctccggggc gcccgggtac cgggcgcggc ggggcgggcc ccgggacggg
     5401 cgccgtcagg aaccgctgag cagcaggtag agcaccgcca tacgcaggct gacaccgttg
     5461 gcgacctgtt cggtgacggt acaccggggc gagtcggcga cctcggcgga gatctccata
     5521 ccgcggacca tgggccccgg gtgcatgacg atggcgtcct cgggcatgcg ggagaggcgt
     5581 tcgccgtcca gcccgtagtt gcggctgtac tcgcgcgtgg aggggaagaa ggactcgtgc
     5641 atgcgctcgg cctgcacgcg cagcatcatg accacgtcgg acttgggcag gacggcgtcg
     5701 aggtcgtagg agacctcgca cggccaggtg tgcaccgaga ccggcagcag ggtgggcggc
     5761 gcgaccaggg tgacgtgcgc gcccagggtg gtgagcagca gcacgttgga gcgggcgaca
     5821 cggctgtgca ggatgtcgcc gacgacggcc acgcgcaacc cttccaggcg gcccaggcgc
     5881 gagcgcatgg tgaaggcgtc gagcagggcc tgggtggggt gttcgtgggt gccgtcgccc
     5941 gcgttgagca cggagccgtc gacccagttc gcgaggcggt gcgcggcgcc cgaggcgctg
     6001 tgccggatga cgacgccgtc ggcgcccatg gcctgcagtg tcagagcggt gtccttgagg
     6061 ctctcgccct tggagacgct ggagcccttg gcggagaagt tgacgacgtc cgcggacagg
     6121 cgcttggccg ccagttcgaa ggaggtgcgg gtgcgggtgg agtcctcgta gaagaggttg
     6181 accacggtgc gcccgcgcag ggtggggagc ttcttgacgg agcggtcgcc gacctgggcg
     6241 agttcggcgg cggtgtccag gatgagggtg gcctcgtcgt gggacaggtc tccggtggag
     6301 agcaggtggc gcatcagtcg ttccccccgg tggtggaggg cgacgaagag ggaggctcct
     6361 cggccgcagg ccgtcggttg agggtggtgg agggcgacga agagggaggt tcctcggccg
     6421 caggccgtcg gttgagggtg gtggagggtg acgggcgggc gggcccgagc agcaccgcgt
     6481 cgtacccgtc ggtctcgtcc aggcgcacgg tgacgctctc gcgcagggag gtgggcaggt
     6541 tcttgcccac gtagtcggcg cggatgggca gttcgcggtg gccccggtcg acgaggacgg
     6601 cgagttggac ggcgcggggg cggcccaggt ctccgagtgc gtcgagggcg gcgcggacgg
     6661 tgcgtccgga gaagaggacg tcgtcgacca ggacgacgac gcggtcgtcg agaccgccca
     6721 cggggatctc ggtcctgccc agggcacgga cgggggcgga gcgcaggtcg tcgcggtaca
     6781 tggtgatgtc gagcgagccc gcggggacgg tacggtcctc cacgcgttcg atgagccgcg
     6841 ccaggcgccg ggcgagcggg actccgcggg aggggatgcc caggagggtg acgtcctgtc
     6901 cgcccttggt gcgttcgagc acctcgtggg cgatacgggt cagcgcccgg ttgatctcgt
     6961 tgccctcgag gacggctcgt gtgccctcgg gcatcggagg agcctcgggc acaccgccac
     7021 cggaatcacc cggggtcggt ttctgcgcac gcaaagtagt gactcccttc cctgcctcac
     7081 tgaacaggtc gttaaaggat gtcgatcgga gccacgctac cagcggcggc cggggagccc
     7141 ggagcgcggt cggcaccccg ggtcacgagt gtgactctca tcacattcta gacccgtaca
     7201 cacctatccg aatgtagtca tgtcgccaca cacgggattc gcccatgaac cgggtgaaac
     7261 ctgaaatacc caggagggac gggcttttcg ggccatcgtg gcgcacgact cgtcccgttc
     7321 ggtccgcaca tgagaggtgt ctcacttacg cacggtttgg ccactgatta gtcgcgtttc
     7381 acaccaacgg cttgacctgg gaggcagacc cccctaccgt cactgtctgt aaccactgcc
     7441 gggtggggtt gcatcccgtg accatccgct ggaccgcata ggcggcccgc cgagtacgag
     7501 cggacgtctc ccccaccacg ccagccaccg tcacggccgg gagcgacaag aaatgccatc
     7561 cgaatacgcc aagtccctcg gtgcgcggct gcgtgccatc cgcacccagc agggcctgtc
     7621 cctgcacggg gtggaagaga agtcccacgg acgctggaag gccgtcgtgg tcggctccta
     7681 cgagcgcggc gaccgtgccg tcaccgtcca gaagctcgcc gagctggccg acttctacgg
     7741 tgtgccgatg tcggagctgc tgcccggcgg cgcggctccc accccgctgg gacccacacc
     7801 caagctggtc atcgacctgg agcgcatgca gcagctgccg cacgagaagg ccgggccgct
     7861 ctcacgctac gtcgccacga tccagagcca gcgcggcgac tacaacgggc gggtgctctc
     7921 catccgccag gaggacctgc gttcactcgc ggtcatctac gacaagtcgc ccggcgacct
     7981 gaccgaggag ctcatcaact ggggtgttct cgaccctgag gcgcgtcgcg cggtcgacgc
     8041 cttctagggg cggaccgtcc aggacacggc agacgaggaa ccccacccgc tcgacgagag
     8101 ccggcgccga ggcgccggct ctcgtcgttt ccggggcgcg tggtgggacc cgggagggcg
     8161 gtgcgagccg gacgtggggc ttcccctccc caacccggcc gcaccgcccc ctccgccgag
     8221 cgggggaccc ggcggagtcg gtcgaactcc tgttcgacac cgtccagtta accccagccc
     8281 gacggacccg tcaagaaccc ctcggggccc gcgcgccgtc cgcgccgaac ccgggcgggc
     8341 cccgcggttc ggggctagtg ttggggtgtg gacgccgata ccgaactgcg tgaactggcc
     8401 ccacccgcct tcacgcacgc cgtccccgcg ctgctccagg tgtacgaggc ggccatgcgg
     8461 ccgcccccgg agcagctgcc gggacgagcg tccgtcatga acaaccacgc cggccatccg
     8521 ggctttcgcg cggtggtcgc cgtgcgcggg ggccacccgg tcggcttcgc ctacgccttc
     8581 cacgggtgct cgggacagtg gtggcacgac acggtcgtgc gggaactgca cgcgtgcggg
     8641 cggacccggc aggtgcgccg ctacctgtcc gacccgctgg agatcgccga ggtgcacgtc
     8701 cacccccgcg cacagggccg gggcgtggga cggtccctgc tccacgccct gtgccggggc
     8761 cgcccggagc ccaccgcggt gctgtccacc cgttcggggc cctccgtggc gcgccacctg
     8821 taccgctcgt gcggcttcac cgaggtgctg gaggacttct ccttccccgg cagccccggt
     8881 cagcccttct cgatcatggc cgcccggctg cctctggccg gctccggtga ccggcgatct
     8941 cccgatagat ctgcctggtg gccgtggact ggttcgaggt gatgaagtgg atgcccggcg
     9001 cgccctcggc cagcagccgc tcgcacatgc gctgggcgta ctcgatgccg aaggcccgca
     9061 cggcctcggc gtcgtcgccg aaggactcga agcgctcggc caggtcgcgc gggaagggcg
     9121 ccccggagag ctgctccgag cgcgggatga acgaggtgcg caccacgggg aacacctcgg
     9181 ggatgatggg cacctcgcag ccgcgcgcgg ccacccggtc gcgcaggcgc aggtagtcct
     9241 cggggtcgaa gaacatctgc gtgatggcgt agtcggcgcc cgcctcgcac ttgcgcacga
     9301 agtagtcggt gtcggtctcg acgtcggccg agcgcgggtg cttgaacggg aaggccgcca
     9361 cgcccacgca gaagtcgccg ctgtccttga tgaggcggac cagttcctcg gcgtaggtca
     9421 gcccctcggg gtgggtgacc cactcgccgt tggggtcccc gggcgggtcg ccgcgaacgg
     9481 cgagcatgtt ggacacgccc gcgtcggcga ggcgccccac gaggtggcgc agttcggcga
     9541 cggagtggtc gaccagggtc atgtgcgcga ccgggagcag ggtggtgtcg gtcgcgatgc
     9601 gctcggtggt ctccaccgtc atcccgcgcg tgctgccgcc ggcgccgtag gtgaccgaga
     9661 cgaaggaggg gccgagggcc tcgatctccc ggatggcgcg ccacaggcgc tcctgcgccc
     9721 ggggcgtgcg cggggggaag aactcgaagg agaacatcgg ctcgcccgcg tcgaggagct
     9781 cgcggatatg acgcggcctg ggggccgggt ttctgggcgc cacggggcgt gtcggtgctg
     9841 acagcatgga caccaccata ggcgaggcgt cccctcccgg tgggagtgac gtcccactcc
     9901 gtgagaccag tggcggacac cacttccggg cacggcccgg ggcgggccgg ccaggcgagg
     9961 gatgaccggc ccgtgccgga cagccgataa tgtgcggacc atggtgcctt cctcttcccc
    10021 gtccgcctca cccgtctccg tgatccgctc cgacgtggac catgagctgt ccggattcag
    10081 tgccgcccac cgggcccagg tcctggagat cggcgaggaa ctggccccgg cgatggacgc
    10141 gctggaggcg atgctctccg gcggcaaacg cctgcggccc accttctgct actggggatg
    10201 gcggggagcg ggcggcgcgg ccgacgacga gcgggtggtc cgggccgcgg cctccctgga
    10261 gttcctccag gcgtgcgcgc tcgtccacga cgacgtgatc gacaacagcg acacccgccg
    10321 cgggatgccc gccacccaca aacggctggc caagctgcac gccgaccacg ggtggagcgg
    10381 cgacagcgag ggcttcggca tgggcgcggc gatcctcatc ggcgacctgt gcctggtgtg
    10441 gtccgacgag atgtaccagg ccagcggctt ccccgcggag gtgctgcggg acgggcgccc
    10501 cccgttcgac gcgatgcgca ccgaggtgat ggccgggcag tacctggaca ccctggagca
    10561 ggtgcggggc accgccaccc gcgaggccgc gctgcgcgtg atgcgctaca agtccgccaa
    10621 gtacacggtg gagcgcccgc tgcacctggg cgccgccctg gcgggccgcc acgaggagct
    10681 ggccggggtc tacaccgcct acggcatccc gctgggcatc gccttccagt tgcgcgacga
    10741 cgtcctgggc gtgttcggcg acccctccac cacgggcaaa cccgcgggcg acgacctgcg
    10801 cgagggcaag cggacgctgg tggtcgccga gaccctggca cgcgtgggcg cggccgacgc
    10861 cgagcggttc cgctcgctgc tgggcgcgcc ggacctgtcg gtggagtcgg tggggtggat
    10921 gcgctccctg atcgaggagt cgggcgccct gatggtgtgc gagaagatga tcggcgagta
    10981 cgccgacgag gccgtccggg ccctggagag cccggagctg gacgccgacg cacgcgagcc
    11041 gctgcgccgg ctggtggtgg cggccacctc ccgctcccac tgactcccgg ttcccgccgg
    11101 ggtcctctcc tcgggccctc acccgacggc ttcaggggtt ctccctaggg gtttttgaag
    11161 ggttcctccc ccgcgggggc gtattgtgcc cggcaaccgc ctccggttga atcaaaagaa
    11221 gacatatctc gaccggaagg ccttccatgc ctgggcacgc cgttgcacgc ggaccggccg
    11281 gggcgggtga gcgggcgctc gcccccgacc tggcacgcgg gtccatgctg ctgttcatcg
    11341 cgatcgcgaa cacggcctgg tacctgtggg cggtccccat gagcgggatg agcgcccacc
    11401 cggaacccgc gggcgctctg gacgccgtcg cgcagttctt caccgtcatg gcggtggact
    11461 cgcgcagcta tccgatgttc gccttcctct tcggctacgg catggtgcag ctggcccggc
    11521 gccaggaggc cgcgggcacc agtgcgcggg acgtggacgc gctgctgcgc cgccgcaacc
    11581 tgtggctgct cgtgttcggc ttcgtgcacg ccctgctgct gtggatgggc gacgtcctgg
    11641 gtgcctacgg cctggcgggg ctggtgctgg gctggctgtt cctccggcgc gcggacagga
    11701 cgctgctggt gtgggccggc gcgatcaccg ggctgatgct gctgctgtcg gcgttcagcc
    11761 tggtggggct ggcgttcacc cccgccgacg gcgccgcatc cccggcgccc ggcctcgaac
    11821 aactggccgc caacatcggc gaaccctcgt tgtggggcgc cgcgctgggc cgtctgacgg
    11881 cgtggccgct cgtcgtcctg ggccagggcc tgctgggcct ggccgtgccc acggcgatcc
    11941 tgctcggcta ctgggcggcg cgccaccgga tcctggagga gccggggaac aacctggcgc
    12001 tcctgcgcct gaccgcgttc gccggcgtca ccgtcggctg gctgggcgga ctgccctcgg
    12061 ccctggccca ggtcggggtc tgggaactgt cccccacgca ggcgagcatg ctgagcatgc
    12121 cgcacatggt gaccggtctg gcctgcgggc tcgggtacgt gtcgctgatc gccctggcgg
    12181 cgcgccggct ccaggagcgc gggcgcggat ccggcccggt ggtggaggcg ctggccgcga
    12241 ccggcaagcg ctccctgtcg gcctacctgg cccagtcggt gctgtgcgcg ccggtcctgg
    12301 cggcctgggg cctgggggtg ggggcccacc tgacgtcgtg gtcgatgttc ctgttcgcgg
    12361 tcggcgtgtg gctggtgacg gtggtggcgg cccatgcgct ggagcgggcg ggcaggcgcg
    12421 ggccggccga ggtgctgctg cgccgcctgg cctaccgcgg accggtcgcg ggaggcgcgc
    12481 gggagccgga ggagggcccg gtcggcggcc gtgatccgaa ggcgtgaaaa aggggcgtgc
    12541 cggtgagtgc ccggcacgcc ctcgtaacgc aggatggagt gtcatgggcg acgatcacat
    12601 gacaaaccac accatagggg tgaccggggc gaccggggcg ctgggcgggc gggtcgccgc
    12661 ccggatcgcg aggctgggga tgtcccagcg gctcatcgta cgtgacatca accgcgcccc
    12721 ggagtatccc ggcagcagcg cggcgatggc ggcctacgag gacacggagg ccttcgaacg
    12781 ggcgtgccgg ggggtggaca cgctgttcct ggtctcggcg accgagtccg aggaccgggt
    12841 cgacgtccac ctgagcgcgg tggacggcgc gatcaaggcc ggggtctccc ggatcgtcta
    12901 cctgtccttc ctgcgggcgg gcccggcggc gacgttcacg ttcgcgcgca cccacttctt
    12961 caccgaggcg cacatccggt cgaccggggt gcggcacacg ttcctgaggc ccagcctgta
    13021 cctggacctg ctgccggact gggtggacca cggcggcgtg gtgcgcggcc cggccggcga
    13081 gggcagggtc gcgtgggtct cgcgggacga cgtggcggac gtggccacgg cggtgctgac
    13141 cgacccgatg accacgctca gctccgacaa cgccacctac gacgtcaccg gccctgaggc
    13201 cctgtccctg ggcgcggcgg tggacaggct gagcacgctc accggccgcc cggtccggta
    13261 cgtgcccgag acccgcgagg aggcgctgga gtcgcgccgc ggcggcggcg cccccgactg
    13321 ggccgtcgag ggatgggtgt cgtcgtacga ggcgatcgcc tccggggaac tggacgtggt
    13381 cgcgcccacc gtccccgagc tgaccggaca cccggcccag tccatcgagg gcttcctccg
    13441 gcgccatccc agtgccctgt cacacgtcgc ggtctgaccc cgggccgcca ccccgccacc
    13501 gccgtgcccc gcgcgcggcg gttccaccgc ctgcgggccg ctgcgccgcc ggctttctcc
    13561 acggcggcat tgacctcaag cattgttgag gaagaaggat gtgcggtgtc ggcgaggcgg
    13621 acacggagga gaagagatgc gcgcggtggt ggtggacgga ttcggcggtc ccgaggtcct
    13681 ggtggcccgg gaggtgtccg aacccgaggt ggggcccgga cgggtactgg tggaggtcgg
    13741 ggcgtccaac gtcatgtatc tggacaccct ggtccggagc ggctggggag gggagtactt
    13801 ccccgtgtct cccccctacg tccccggcgc gggagtggtc gggcgggtgg ccgcgctcgg
    13861 tgaggacgtg gacccgggct ggacggacgc cctggtggtc accgacaccg ggcacacgga
    13921 cgcgtcggag gggcgtacca ccctgcccgt ggacggatac gccgagcggg ccgccgttcc
    13981 ggagtcggca ctggtcaggg tgcccgaggg ggtggacccg aaggcggcgc tggcactgct
    14041 gcacgacggg ccgaccgcgc tggcgctgga gcgggccgcg gccttcggcc ccggcagcac
    14101 cgtcctggtc gccgccgcca ccggcggggc gggcagcctg gccgtccaac tggcccgtgc
    14161 ggccggagca cgggtcctcg ccgcggcccg gggagaggcc aaactggcgc tcgcccgtga
    14221 gctgggcgcg cacgaggccg tggactactc ccggccgggc tgggagaagc gggttctcga
    14281 gctcaccggg ggcaccgggg tcgacgtcgt cctggacggc gctgggagcg ccctgggcga
    14341 ggcggccttc ggggccgtgg ccgacggcgg acgcttcatc ggctacggaa cggcgggggg
    14401 ccgcttctca gaggtggaca ccgaggaggc cgggcgccgc ggtgtcgagg tactgggcct
    14461 gttcgacctg caggcacagg accccgacga caggcgaagc gccctgcggt acatgctgga
    14521 gctgacccgc cggggcgaga tcaccccgca cgtagggctg gccctgccgc tggagcaggc
    14581 gagccgggcg cacgccgcgc tggaggggcg cacggtcctc ggcaaggtcc tgctggtgtc
    14641 ctgaaccggg gccgggcgcc cgtgcctcag ccctgtccgg gtgtcctggc ggtcaggcgc
    14701 cggcgcagct ccgcggcggc ggcccggggg tccggcgcct ccgtgatcgc gcgcacgacc
    14761 acgaccctgc gggcaccggc gtccagcacc tggtcgatgt tgtcggcgtc gatcccgccg
    14821 atggcgaacc aggggcggtc ggcgcccagg gccgcggccc gcctcaccag gtccagcccg
    14881 gcggccgggc ggcccggctt ggtgggcgtg gcccaggtgg ggccgacaca gaagtagtcg
    14941 ctgccggggt cctcggcgga ggcggccgcg gcgtcggcgt cgttgttgga gcggccgatg
    15001 aggggatcgg cgccgatgat gtcgcgggcc atggggacgg gcaggtcgcg ctggcccaga
    15061 tggaggacgt cggcgcgcac ggcgcgggcg atgtcggcgc ggtcgttgac cgcgagcagg
    15121 gcgccgtgcc gctcgcaggc atcctgcatc acctccaggg ccgcgatctc ctcccgggcc
    15181 tccaggccct tgtcccggag ctggatgatg tccactcccc cggccagggc ggcgtcggcg
    15241 aactcggcga gatcgccccg cccggtccgg gcgtcggtgc acaggtacag aagggatgtg
    15301 tccaggcgct tgcgcaggct ggttccgtgg ctggtcctca caccgctcac cttaggccct
    15361 gagccgggcg ggcccaaggg gagggagcgc gacggcgcgc cccccgcaga ttccggtccg
    15421 aaccgtgtgc ggggggcggg ttccacggga ggagccgggc cgcgacgggt gctgcgccgt
    15481 aggcgtccgc tgaggatcgc ggcgggcgac ggcgtgggca cgggcctcag gcgtgggcga
    15541 cgccgaagaa ccccggtcct tggcgccccg agcccttcgt gaggaaccac ggccggaggc
    15601 cgaccgtcga ggatggtgga gggtgacggg cgggcccgcg ggcacgcgaa ctagaaggcc
    15661 atgctctgcg cgcggcggcg cacctcggtg ccccggttct cacgcatggc ctggatgggc
    15721 gtgcccggca gggagtcgtc gggtgtgaac agccagcgca gggcctcctc ggtggagaac
    15781 cccgcgtcgc tgagcagcat caccgtgccc ggcagtccct tgaccaggtc gtggccgtcg
    15841 acgaacgcgg cggggatgga cagctcacct ccgcggacca cgcccatcag tcggttctca
    15901 cggatcagtg tcttgatccg gttcgggctc acgcccagcg gctgggccgc ctccttgagg
    15961 gtcagccact cgccgaccag tgcgtcgatg tccatgtcgc tttgtgtcac ggcaccaatc
    16021 tgccacatcc ccgcacgtgc ggtgcacctg tggcgcggat gagacggctc tcggctcgga
    16081 atccgcccgt ttcccgctcc ggcggaggcc ccagggcgtg ttcggcggac acgccctaga
    16141 atggggacgg acccacacat cccgcgggag ccgggtgata cccggctgag agggaggctg
    16201 gcagcctccg accgcacgaa cctgatccgg atcatgccgg cgaagggagg ggagaccagc
    16261 gccgtgcgca cttcgaacac cccccgctcc cccatggggc accccaccga cggacgtgcc
    16321 ggcgaccgcg gcgtcgtcgt ggtcggcggc ggcctcgtcg ggcgtgtcac cgcctggcgc
    16381 gccgcccaac gggggctgtc cgtcaccctg gtcgaacccg accccgtggc cgacccggcc
    16441 ggggcccgcg ccgcctccac cgtcgcggcg ggcatgctca cccccgccac cgaggcggtg
    16501 ttcggcgagg agcccctcat ggagctgggg gtccgctccg ctgccatgta cgccgacttc
    16561 gtcaccgaac tggaggaggc cagcggcctc ggcgtgggcc accgcgccac cggcacgctc
    16621 ctggtcgcct tcgaccgcga cgacctggcc gtcctcaccg aactgcacga actccaccag
    16681 cgcctgggca tcgccaccga acgcctgacc agccgcgggt gccgacgcct ggagccgatg
    16741 ctggccccgt ccgtgcgcgg cggcctcctg gcccccgacg accactccgt ggacccgcgg
    16801 cggctgctgc gcgccctggc cgtggcgggc gagcgcgcgg gcgtcaccga gatcgccggg
    16861 cgggccgagg aggtcctcgc ccccggcccg gacggcaccc ggctgggcgt gcgcctggac
    16921 gacggtcggc tgctgcccgc cgaccaggcg gtcctggccg cgggctgctg gggcgacgcg
    16981 gtcggggtcc ccgagccggt ggtcccgccg ctgcgcccgg tcaagggcca gctgctgcgc
    17041 gcccgggtgc ccgccggtga gccgccgatc gtcggccgga cggtccgcgg actcgtcagg
    17101 ggctttccga cctacctggt gccgcgcgcc gacggcgagg tggtcatcgg cgccacccag
    17161 gaggagctgg gccacgacac ctcgctcacc gccggggggc tgtggcaggt gctccgggac
    17221 gcacgcgaac tcgtccccgg ggtgagtgag ctggagatca ccgagacctg tgtgggcctg
    17281 cgcccgggct cacccgacaa cgagcccctg ctgggcccca cccgggtacc ggggctgcac
    17341 ctggccgccg ggcacttccg gcacggggtg ctgctgaccc cggtcaccgg cgaggtcatg
    17401 gcccgggcac tgaccaccgg cgtcctgccg gagtacgccc agcgcttcgc cgcggaccgg
    17461 gtgttcggcg gcgggggcac gacgaagcgg aagcagtggg agtagcagtg gaactgatca
    17521 tcaacggcga ccgccgcgag gttaccgacg acaccacggt ggaggcggtc gtgcgcgacc
    17581 tgaccgccgc cgcgaacggt gagatccccg gcggtatcgc cgtggccgtc aacgacgagg
    17641 tggtgcgccg cgccgcgtgg tccgacaacg cgctgggcgc gggtgaccgc gtggacgtcc
    17701 tcaccgcagt acagggaggc tgagcatggc cgagtacacc gcccgcgccg acgacccgct
    17761 cgtgatcgcg gggaccgcct tcggttcccg gctgatcacc ggcaccggag gggctccctc
    17821 cctggaggtc ctggaggagg ccctggtcac ctccggcacc gagttgacca ccgtggcgat
    17881 gcgccgggtc tcccccgcca cccagggatc ggtgtgggac atcctcaccc gcaacaagat
    17941 ccgggcgctg cccaacaccg ccgggtgctt caccgcggcc gacgccgtac gcaccgcccg
    18001 gctgggccgt gaggcgctgg gcaccgactg ggtgaagctg gaggtggtgg cggacgagca
    18061 cacgctgctg cccgaccccg tggagctgtt ggaggccgcc gagcaactgg tggacgaggg
    18121 cttcgtcgtc ctgccctaca ccaacgacga cccggtgctg gcccggcgcc tggaacagct
    18181 gggctgtgcg gcggtgatgc cgctggccgc gccgatcggg tccgggctgg gcatccgcaa
    18241 cccgcacaac ctggagctga tcgtggagca ggccggcgtg ccggtgatcg tggacgccgg
    18301 gatcggcacc gcgagcgacg cggccctggc gatggaactg ggctgcgacg cggtgctgct
    18361 ggccacggcc gtgacccggg cccaggagcc ggtacggatg gccgcggcga tgcgcgacgc
    18421 cgttcgcgcg ggccgcggcg cccggctggc cgggcgcatc ccggtgcgcc gccacgccca
    18481 ggcgtcctcc cccgggatcg actagcgcgg cggccgggag caggccgggg agaccgacga
    18541 gagttgggac actctcacgg acacacgcat gtggccgatg agatcaaagt gattcctgaa
    18601 accgatgtgg cgttctgtgc cccttccgac cccgacggga ggggaacgga gcgccgtcgg
    18661 cccggtccgc gagggcgtcg accgtggtca gggccgcccc gccgagtgcg gcgtgaggcg
    18721 ggtggttcac gcccggggcg tttggccccg tcccctaccg tggaaaaggt gtgcgccccg
    18781 gccgcgaggg cagcgcgcgc acgaagacga cccaggcgcg agcatcccca ccaacggtgg
    18841 agcggggcga cgcgaccgtg aaccgcgggg cagactccgc gcgggcttcc gctatcgtgt
    18901 cggttcgaca cccggtgtcg ggtacgcgcc accggccgcg acagcccgcg ctccccgcag
    18961 caaggacact actccgccgt ggacatgacg acttccgacc cgctcgtagg caccaccctg
    19021 gaccgacgct acttcgtcga gtccaggatc gccggaggcg ggatggcgac cgtctacgtc
    19081 gcccacgacc tgaggctgga ccggcgcctg gcgctgaagg tgatgcatcc ttcgctggcg
    19141 caggacccca ccttcgtcca gcgcttcatc aacgaggccc actccgtcgc caagctctcc
    19201 catcccaacg tggtccaggt cttcgaccag ggtgaggacc aggggcacgt gttcctggcc
    19261 atggagtacg ttcccggacg cacgctgcgc gacctgctca aggcccaggg gcgcctggcc
    19321 ccgcgcgacg ccctgaacgt gatggcctcc gtgctggccg ctctgggcgc cgcccaccag
    19381 gcgggcatgg tgcaccgcga cgtcaagccc gagaacgtcc tcatcaccga ggacggccgg
    19441 gtcaaggtcg ccgacttcgg cctggcccgc gccgtggagc agtccaacca gggcctgacc
    19501 cgtaccggca ccctcatggg cacggccgcc tacctggcac ccgagcagat cgagcggggc
    19561 accgccgacg cgcgcagcga cgtgtacgcg gcgggcatca tgctctacga gctgctcacc
    19621 ggcggccagc cgcacaccgg cgagacgccc atcgcgatcg cctaccagca cgtcaacgag
    19681 gacgtcccgc gcccctcgca cttcctgccg ggcctgccgc ccgaggtgga cgggctggtc
    19741 accaaggcca ccgaacgcga tccccggtac cgcctgggca acgcgggcca gtacctggcc
    19801 aaggtcctgg aggtcctcaa cgtcctgccc gcctcctcca cggcgggccg ggccccgctg
    19861 acgcccgtca ccccgacggc ggccacgtcc tcggtcaccg ccccgcagct catcgccggc
    19921 ggggccggcc cgggcaccga gaacgccacg atgatcgtgg acatgaactc cgccggcctg
    19981 gacggggacg gatacgacgg ctacgacgat gacgacgggt acgacgacta ccggagcgga
    20041 cccgacgacc ggcgccgccg caacctgctg atcgggatcg gcgcggcggt cctggcggtc
    20101 atcgtgctcg gttcgggctg gtggttcctc tccggccgct acgcggacgt tccggacgtg
    20161 gtcggttccg cccccgaggc cgcacgggag ctgatccgct ccgaggggct ggtctacgta
    20221 ctctccgacg agaccgtcta cagcgacgtc gaggccggcg cggtcgccga gaccgacccc
    20281 gcggccgggg agagcctgtc ccccgacgcc gaggtcaccg tccacctgtc caaggggccg
    20341 cagaaggtgt ccatgcccga cctcgagggc gaggactccg ccaacgccct caagcagatg
    20401 gaggacctcg gcttcgcccc ggagaacgtg gtccagaagg aggtggacgc cgaggacgtc
    20461 gagccgggaa cggtggtctc caccgacccc gcggccgggg aggaggccga ccgggagggg
    20521 acggtcacga tctccgtcag ccgcagcatc tcggtgcccc ccgtggtcgg ccaggacctg
    20581 gagggcgcgc gcacggccct gcaggacctc ggcctgaccg tcgaggtggt cgagcaggag
    20641 agcgaggacg tcgccgaggg caaggtgatc cagcagagcc cggacagcgg cgccggcgtc
    20701 ggcgcgggcg acaccgtcac cctgaccgtc tccaccggcc cgccgggtgt ggccatcccc
    20761 gacgtggtcg acatgaaggt gaaggacgcg cgcaaggccc tggaggaggc cggcttcaag
    20821 gtcaaggtcg agaagctctt cggcggcgac gtcgtgacgc accagtccca caccggcaag
    20881 gcccccaaga agacggagat cacgatcacc gcgaccccgg gcggcatcga cctgggcgac
    20941 ttcggcgacc ggggcgacga ctgacgcacc ccgggggggc gccgcccccg gagcgtggga
    21001 gcacggcctc gggaaggggc gtgcgggcag gccgggcccg cacgcccctt cgacgttccc
    21061 cggccccgcg cggacgcggg cgg
//
