LOCUS       NZ_MCOK01000001        21344 bp    DNA     linear   CON 22-OCT-2024
DEFINITION  Nocardiopsis sinuspersici strain UTMC 00102 NOSIN_1, whole genome
            shotgun sequence.
ACCESSION   NZ_MCOK01000001
VERSION     NZ_MCOK01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Nocardiopsis sinuspersici
  ORGANISM  Nocardiopsis sinuspersici
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsidaceae; Nocardiopsis.
REFERENCE   1  (bases 1 to 6071583)
  AUTHORS   Tokovenko,B. and Kalinowski,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-AUG-2016) Helmholtz Institute for Pharmaceutical
            Research Saarland, Helmholtz Centre for Infection Research, Campus
            C2.3, Saarbrucken 66123, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 20-JUL-2016
            Assembly Method                   :: SPAdes v. 3.8.1
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 106.0x
            Sequencing Technology :: Illumina NextSeq; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001998325.1-RS_2024_10_22
            Annotation Date                   :: 10/22/2024 13:01:47
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,351
            CDSs (total)                      :: 5,274
            Genes (coding)                    :: 5,224
            CDSs (with protein)               :: 5,224
            Genes (RNA)                       :: 77
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 50
            CDSs (without protein)            :: 50
            Pseudo Genes (ambiguous residues) :: 0 of 50
            Pseudo Genes (frameshifted)       :: 13 of 50
            Pseudo Genes (incomplete)         :: 44 of 50
            Pseudo Genes (internal stop)      :: 2 of 50
            Pseudo Genes (multiple problems)  :: 7 of 50
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 18:06:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2567839
            Orig. end                         :: 2589183
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            MCOK01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21344
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="6"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21344
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21344
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11344](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11344)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(148..163)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.32"
                     /tool="antismash"
     misc_feature    336..349
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     gene            775..1290
                     /locus_tag="NOSIN_RS11045"
                     /old_locus_tag="NOSIN_10900"
     CDS             775..1290
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013153640.1"
                     /locus_tag="NOSIN_RS11045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_10900"
                     /product="DoxX family protein"
                     /protein_id="WP_077690653.1"
                     /transl_table=11
                     /translation="MAPLIVLVGVTALLLALGAAGVRPLRSWPPALRGGLAAMFTLTGV
                     SHFVGMREVMVAMVPPALPAPELLVTVTGILELAGAAGLLWARTSPWAAAGLGVLLVAM
                     FPANVHAITTQVSTGLTDNLPVRTAMQVVFLAATLAVLVHHLRAGRRVDPVGTATPQRH
                     RTESTEQT"
     misc_feature    complement(815..830)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.5"
                     /tool="antismash"
     gene            1380..2198
                     /locus_tag="NOSIN_RS11050"
                     /old_locus_tag="NOSIN_10905"
     CDS             1380..2198
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017570449.1"
                     /locus_tag="NOSIN_RS11050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_10905"
                     /product="metallophosphoesterase"
                     /protein_id="WP_077690654.1"
                     /transl_table=11
                     /translation="MSLLAISDLHVRHGDNRAFTEDLRPDSEDDWLLVAGDVAETTADI
                     LWAMELLADRFATVVWVPGNHDLWTVPADPLQLRGQERYQYLVEALRGLGVHTPEDPYP
                     LWPGPDGPVVVAPLFVLYDHTFRPEGTSTKEEALAVAHEAGVVCTDEYLLHPDPHPGRD
                     AWCRARLEYTRARLDSLDPDLPTVLVNHFPLVREPTRILRYPEFAQWCGTEATADWHVR
                     YRARAVVYGHLHIPRTIVVDGVPHVEVSLGYPREWGARPLPPEGPRRVLP"
     gene            complement(2849..3031)
                     /locus_tag="NOSIN_RS11055"
                     /old_locus_tag="NOSIN_10910"
     CDS             complement(2849..3031)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NOSIN_RS11055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NOSIN_10910"
                     /product="hypothetical protein"
                     /protein_id="WP_143832917.1"
                     /transl_table=11
                     /translation="MNVTVILVTATAITFFLVGAVLVATFAMAALSHNQNRMQRRLRHW
                     QDEAVRLSRAGDPER"
     gene            3278..4336
                     /locus_tag="NOSIN_RS11060"
                     /old_locus_tag="NOSIN_10915"
     CDS             3278..4336
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NOSIN_RS11060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NOSIN_10915"
                     /product="hypothetical protein"
                     /protein_id="WP_077690656.1"
                     /transl_table=11
                     /translation="MYVSIPHAQGEYGHALRELRRGIGCTPDRLSESTLLERTLRERIE
                     SRGEEVTADRLIMELTHLIDSIGDPKFRESLLVALRLDLRYRQRTLMERRRNYNRDLRN
                     SPDSEMRRLHVDNLRTMERRENKATEQVARYLDDGLQVSDRAHLRDFPLRPIAPQGELA
                     VEAISYSCAFSDTGVLRTQDVTRWVRATSPQTSPELTVTHRYFNENKTGLLDIESLYGC
                     RVVERSETVSGDLLARISIHKDLAPTDGVYSFGSRISVNSDATCRPVIVWRPRTSFTRR
                     IEFHLRFGEPHLPVRAWWFVSSQEVEGELEPPPSEGRHLEHLDEGRYLYRIFENEDITP
                     DLRYGISWVWPG"
     gene            complement(5054..5848)
                     /locus_tag="NOSIN_RS11065"
                     /old_locus_tag="NOSIN_10920"
     CDS             complement(5054..5848)
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017613455.1"
                     /locus_tag="NOSIN_RS11065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_10920"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_143832918.1"
                     /transl_table=11
                     /translation="MTTPPLVDTTVSHSARVWNYWLGGKDHYPVDREAGEQIAAVLPEI
                     VDIALATRSFLMRVVTHLVRSEGVDQFLDIGTGLPTANNTHEVAQAANPAARVVYVDND
                     PLVLAHARALLSGAPEGATDYVHADLRDPAAILAEAARTLDLGRPVAVTLFGVLPFVGE
                     DTEARAILDHLMGALPPGSFLAIVHSTSAVTGEAMVEAVRRWNEAGSAVYHLRTPERLT
                     ALFDGLELVEPGVVSCPLWRPEPAQVGWAREMDEYCGLARKP"
     gene            6161..6496
                     /locus_tag="NOSIN_RS11070"
                     /old_locus_tag="NOSIN_10925"
     CDS             6161..6496
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017564515.1"
                     /locus_tag="NOSIN_RS11070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_10925"
                     /product="hypothetical protein"
                     /protein_id="WP_077690658.1"
                     /transl_table=11
                     /translation="MERCDFCELPVGGGCACSLGRDGQGTRGQGAGAATGDAHLPGKAI
                     LISPRGVAHRPGCLHQSESEVKAPLWGWITDPDPRLWRRLSAGSPARATHGNTERVATR
                     RCRSCDA"
     gene            complement(6661..6987)
                     /locus_tag="NOSIN_RS11075"
                     /old_locus_tag="NOSIN_10930"
     CDS             complement(6661..6987)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017580317.1"
                     /locus_tag="NOSIN_RS11075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_10930"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_077690659.1"
                     /transl_table=11
                     /translation="MSRNKAVPERRLHHPDRDEIRLESVLSALSDPIRLRIVRELARGH
                     DDMACIAFDLPVSKSTSTHHFRVLREAGVIRQYYEGTSRMSRLREDDLEARMPGLLSAV
                     LGAE"
     gene            7127..8221
                     /locus_tag="NOSIN_RS11080"
                     /old_locus_tag="NOSIN_10935"
     CDS             7127..8221
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017570438.1"
                     /locus_tag="NOSIN_RS11080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_10935"
                     /product="NADH:flavin oxidoreductase/NADH oxidase"
                     /protein_id="WP_077690660.1"
                     /transl_table=11
                     /translation="MSSLFTPLTLRSLTIPNRVWMSPMCMYSAASEGDQAGAPTDFHLA
                     HLADRALGGAGLVMAEATGVRPDGRISPWDLGLWNDQQQEAFSRVTAAIRSHGSVAAVQ
                     LAHAGRKASTNRPWLGGGHLTGAEGGWETVSPSAEAFSGLSTPHELTEAEIDQLVADFA
                     ASAERALAAGFQVAEVHGAHGYLLHSFLSPAANHRTDAYGGGFENRTRFPLRVVEAVRE
                     VWPEDLPVFFRVSATDWLSEDAGDTRRGWTGDDTVLLAKELQARGVDLLDVSTGGVVHD
                     ARIPVGPDYQVPFAARARQEAGVPTSAVGLVTDPRQAEEIVASGRADAVMLGRQLLREP
                     YWAHRAAAELGARPAWPEQYGYAV"
     gene            complement(8338..8955)
                     /gene="idi"
                     /locus_tag="NOSIN_RS11085"
                     /old_locus_tag="NOSIN_10940"
     CDS             complement(8338..8955)
                     /EC_number="5.3.3.2"
                     /GO_function="GO:0004452 - isopentenyl-diphosphate
                     delta-isomerase activity [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="idi"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017570448.1"
                     /locus_tag="NOSIN_RS11085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_10940"
                     /product="isopentenyl-diphosphate Delta-isomerase"
                     /protein_id="WP_077690661.1"
                     /transl_table=11
                     /translation="MPTGPAADHRSTAPLADPEAAFAPGRAPVMLELVDEDGTTVGTAE
                     KISAHLPPGRLHRAFSVFLFDDRGRLLLQRRALGKYHSPGVWSNTCCGHPHPGEPPFVA
                     AARRTCEELGTAPALMREAGTVRYNHPDPDSGLVEQEYNHLFVGLVRGRLRPDPDEVAE
                     TAFADSAELERMCGDLPFSAWFPTVVDAVLPAVRELTGSPEW"
     gene            complement(9033..9887)
                     /locus_tag="NOSIN_RS11090"
                     /old_locus_tag="NOSIN_10945"
     CDS             complement(9033..9887)
                     /EC_number="2.1.1.255"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017570447.1"
                     /locus_tag="NOSIN_RS11090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_10945"
                     /product="geranyl diphosphate 2-C-methyltransferase"
                     /protein_id="WP_077690662.1"
                     /transl_table=11
                     /translation="MTETMAPSVLRTAYQKSVAAYWNAEKDPVNIRLGDVDGLYHHHYG
                     IGDYDHSVLEGPEETRDERVIREMHRLETAQANLLLDHLGPISPDDRIMDTGSGRGGTS
                     FMAHQRFGCHVDGVTISEQQVAFANGQAEERGVADRVRFHFRNMLDTGFEAGSLRASWN
                     NESTMYVDLFDLFREHARLLEYGGRYVTITGCYNDVTGGRSKAVSRIDEHYTCNIHPRS
                     AYFRAMAANGLVPIEVVDLTESTIPYWELRARSSVATGIEDPFLTAYREGSFHYLLIAA
                     DRV"
     gene            complement(10001..11344)
                     /locus_tag="NOSIN_RS11095"
                     /old_locus_tag="NOSIN_10950"
     CDS             complement(10001..11344)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0042214 - terpene metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017544767.1"
                     /locus_tag="NOSIN_RS11095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_10950"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_375539645.1"
                     /sec_met_domain="T1TS (E-value: 2.1e-52, bitscore: 177.3,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPLSTTPATAASPEVVGLVEALLRDPRRPGRRDLLAPASAPAPR
                     TPPAPRLPVGRSGTGTSALRLRLSSPHPADQSPSTAAAGIAPGIPAHPVGARLPGAPAT
                     GAARPRGGTKRPEDDGSPGERGGGEQVPALYCPPAMRDDPALGDEVDGRLVEWAAEVGV
                     YPGQLDRVRAAGFGRLIMLAHPETDDPDRLLAAAKCALAEWSVDDHYVDGEAEEAHPEL
                     LGQRLAIAHSVIDQAHLPRRYAPQLEEVVRGDPVMVALRSSLANLGAYATAAQVRRLRH
                     ELAIMFVAYNQEAVWLATGHRPPVWEFLMHRHENSFVPCMALIDPVAGYELPWAEFAQP
                     SVRRVFTLAGSASVIVNDLYSMGKEDVTDLSLPRLIASEDDCSLSEAVQRTVEVHDELM
                     HAFEAEAAALALSGSPELRRFLWGLWAWLGGSREWHARSPRYHGANGS"
     misc_feature    complement(11338..11350)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.33"
                     /tool="antismash"
     gene            complement(11380..12783)
                     /locus_tag="NOSIN_RS11100"
                     /old_locus_tag="NOSIN_10955"
     CDS             complement(11380..12783)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017564632.1"
                     /locus_tag="NOSIN_RS11100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_10955"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_077690663.1"
                     /transl_table=11
                     /translation="MSIDSAPEIRSGKQQSLGTAAARNLATTTKSVPQMQGISSRWLTR
                     MLPWVHTDGGAYRVNRRLTYTIGDGRIEFSQTGAQVRVIPQELGELALLRGFDDVDVLT
                     ALADRFVQRDFEPGQVLAEEGTSADHLYLLAHGRVHKTSSGHYGDTNWLGVLADGDKFG
                     DRYLLDAEPRWEFTVKAATAGTLLEMPRREFIAILDDSPTLQAHVQEYLSLPEQRQNKH
                     GEAEIALSSGHVGEAELPATFVDYDLKPREYELDVAQTVLRVHSRVADLYNKPMNQTEQ
                     QLRLTIQALRERQEHELVNNREFGLLHNTEFKQRIQTHEGPPTPDDLDDLLSMRRNTQY
                     MFAHPKAIAAFGKECNKRGLNIGTAEVGGHHLPAWRGVPLLPCGKIPVSEHQTSSIIAV
                     RTGEDNEGVIGLYQTGLPDEVEPGLNARFMGIDDRAVISYLVSTYYSAAVLVPDAVGIL
                     ENAEVHPRG"
     misc_feature    complement(12971..12986)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.37"
                     /tool="antismash"
     misc_feature    complement(13154..13168)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.68"
                     /tool="antismash"
     misc_feature    complement(13155..13170)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.54"
                     /tool="antismash"
     gene            13413..14333
                     /locus_tag="NOSIN_RS11105"
                     /old_locus_tag="NOSIN_10960"
     CDS             13413..14333
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231: carboxyvinyl-carboxyphosphonate"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019608486.1"
                     /locus_tag="NOSIN_RS11105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_10960"
                     /product="isocitrate lyase/phosphoenolpyruvate mutase
                     family protein"
                     /protein_id="WP_077690664.1"
                     /sec_met_domain="PEP_mutase (E-value: 1.3e-67, bitscore:
                     226.1, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSPAERAGGHTGVRAARHDSGRIPPGRPRTDRSPEEPAPGERFR
                     ALHLEGDPLLLPNAWDHASAAALAAAGFRAVGTTSLGVAAAAGLPDGQGHTREETLRLA
                     RGLSRLDVLVSVDVEGGFGGSPAQVAALAAELERTGIAGINLEDGLPDGGLADVGRQQE
                     VVRAVRDAAPSLFLNARTDTWWLPGHTGQTADRAAAYEEAGADGVFVPGLRDEEEIAAL
                     SGALRVPLNILHSPTGPPPRVLAELGVRRVSCGSLLFRAALAGALAAAEAVASGLPLPE
                     GVPGYDEVQALAERFAAPRGRSAAG"
     gene            complement(14370..15620)
                     /locus_tag="NOSIN_RS11110"
                     /old_locus_tag="NOSIN_10965"
     CDS             complement(14370..15620)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017570436.1"
                     /locus_tag="NOSIN_RS11110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_10965"
                     /product="DUF5685 family protein"
                     /protein_id="WP_077690665.1"
                     /transl_table=11
                     /translation="MFGILRPCRHTLSDGLAEEWMSHMCGLCLALRDDHGQASRIATNY
                     DGLVVSVLTAAQSEECAGTRRAGRCPLRGMRGAEVADGSGAHLAASVSLMLASAKIADH
                     IEDGDGPYARRGVRALAGRVAERWRREAREAGAGLGFDGAELVAVVDRQREAELAAGPG
                     TDVLTVTRPTEEATGEAFAHTAVLAGRPANVEPLREAGRLFGRVAHLLDAVEDREEDRE
                     RNAWNPLTATGTGIGRARELCDDAVLGVRPALEEAEFADDRLARALLVGELHRAVERAF
                     AHGGYPNPGHQQNEHYRNHPHRPHHQQQFHQERRNGGGSHDAPHGGGHGDGSGPGGNGG
                     KGNCCASCSCDTPELRSSPKPRGVLAGCAAALFMCCTCQFCCRDPHPGPWTGRPRDAWC
                     NLCECCSCCECCSCCDF"
     gene            complement(15760..16452)
                     /locus_tag="NOSIN_RS11115"
                     /old_locus_tag="NOSIN_10970"
     CDS             complement(15760..16452)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017570435.1"
                     /locus_tag="NOSIN_RS11115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_10970"
                     /product="DUF1028 domain-containing protein"
                     /protein_id="WP_077690666.1"
                     /transl_table=11
                     /translation="MYAGTFSIVAYDTAVRTCGVAVSSRMPAIGALSVFAHADAGAVAT
                     QALINPLLGTDALELLRSHTAEDALRRVLGTDPAADSRQVAVVDRGGRAAAHTGSQTHP
                     WCGHRVGAGYAVAGNILTGADTLDAMAERFEAGAGDRMDERLLSALEAGQAAGGDRRGR
                     QSAALYVHTGHPYPYLDLRVDEHSDPVAELRRVHGVARRELLPFVEAMPTRARPAGNFE
                     RLLDTGDH"
     misc_feature    16651..16667
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.79"
                     /tool="antismash"
     gene            complement(16752..17507)
                     /locus_tag="NOSIN_RS11120"
                     /old_locus_tag="NOSIN_10975"
     CDS             complement(16752..17507)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017605161.1"
                     /locus_tag="NOSIN_RS11120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_10975"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_227014381.1"
                     /transl_table=11
                     /translation="MAADSSRMDPDSTASDSTASDSTASDTTAPDPAGPDTAAGPERLR
                     SDARHNRARILEAAREAFAARGLDVPMAAVARRAGVGVATLYRRFPTRESLVTEVFADR
                     LADCVGVVDEALADPDPWRGFRTVIEKVCAMQVADRGFTAAFLTEFPGAVDFERERMRA
                     ERGFAALTRRAQEAGYLRADFARTDLTLVMKANDGVVAESSEAAAAASRRLVAYFLQAF
                     RSDHTTSAPDLPPPAPIGLYRFDLLTEGR"
     gene            17627..18595
                     /locus_tag="NOSIN_RS11125"
                     /old_locus_tag="NOSIN_10980"
     CDS             17627..18595
                     /NRPS_PKS="Domain: PKS_ER (19-315). E-value: 1.3e-40.
                     Score: 131.4. Matches aSDomain:
                     nrpspksdomains_NOSIN_RS11125_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013153662.1"
                     /locus_tag="NOSIN_RS11125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_10980"
                     /product="NAD(P)-dependent alcohol dehydrogenase"
                     /protein_id="WP_077693538.1"
                     /sec_met_domain="ADH_N (E-value: 6e-07, bitscore: 27.6,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 4.1e-11, bitscore:
                     41.3, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAALYDRYGGPEVLYEGTVARPDTGPGDVLVRVHAASVNGGELL
                     GRAGGIRLATWLLDRGFPKRTGNDFAGEVVETGSGVSGFAPGDRVWGALPRTFGSAAEF
                     VAVAPRQLALAPADLNLVEAAALPVVGTTAVTALRDRARLAPGERLLVRGASGGVGSVA
                     VQLGRAYGAHVTALAGAEHLGFVRELGADEAFDYAGTGAADLPPFDVVLDTVGTGLRAY
                     RRRLTGNGRIVAITFDSGRMLASLSYIAASAVFGSRRVRFFSGDPGHELFAELTRLTES
                     GAVRPVVDRILPLAEIAEAHRALEAGGIRGKVVVSVAGPGA"
     aSDomain        17684..18571
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NOSIN_RS11125_PKS_ER.1"
                     /evalue="1.30E-40"
                     /label="NOSIN_RS11125_PKS_ER.1"
                     /locus_tag="NOSIN_RS11125"
                     /protein_end="315"
                     /protein_start="19"
                     /score="131.4"
                     /tool="antismash"
                     /translation="VARPDTGPGDVLVRVHAASVNGGELLGRAGGIRLATWLLDRGFPK
                     RTGNDFAGEVVETGSGVSGFAPGDRVWGALPRTFGSAAEFVAVAPRQLALAPADLNLVE
                     AAALPVVGTTAVTALRDRARLAPGERLLVRGASGGVGSVAVQLGRAYGAHVTALAGAEH
                     LGFVRELGADEAFDYAGTGAADLPPFDVVLDTVGTGLRAYRRRLTGNGRIVAITFDSGR
                     MLASLSYIAASAVFGSRRVRFFSGDPGHELFAELTRLTESGAVRPVVDRILPLAEIAEA
                     HRALEAGGIRGKVVV"
     CDS_motif       18065..18124
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NOSIN_RS11125_0001"
                     /evalue="4.00E-05"
                     /label="PKSI-ER_m5"
                     /locus_tag="NOSIN_RS11125"
                     /protein_end="166"
                     /protein_start="146"
                     /score="16.2"
                     /tool="antismash"
                     /translation="GERLLVRGASGGVGSVAVQL"
     gene            18764..19261
                     /locus_tag="NOSIN_RS11130"
                     /old_locus_tag="NOSIN_10985"
     CDS             18764..19261
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017564620.1"
                     /locus_tag="NOSIN_RS11130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_10985"
                     /product="hypothetical protein"
                     /protein_id="WP_171986580.1"
                     /transl_table=11
                     /translation="MSTDHERPRPLPRPITGVFVRHLLHTACPRYFAMVWADFEPLRDD
                     GTGEAFAFVDDLPDRCREPGEPLPKEFVRAFTEGAREVWENSGGDRPLFAARVVLRDAV
                     WHDNDSNPQSFRMAGRLAAREALCCVAEGREPRQAGRSGRSDSPIPPMPRTLPPPDPAP
                     PA"
     gene            complement(19325..20014)
                     /locus_tag="NOSIN_RS11135"
                     /old_locus_tag="NOSIN_10990"
     CDS             complement(19325..20014)
                     /GO_process="GO:0042546 - cell wall biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013153664.1"
                     /locus_tag="NOSIN_RS11135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_10990"
                     /product="SMI1/KNR4 family protein"
                     /protein_id="WP_077690668.1"
                     /transl_table=11
                     /translation="MDTSTDVWAGVREQVLELGRAPGAGEVFGARHHGFELLDPLTHGE
                     LAELEGQLGTRLPAGYREFLLRVGAGGAGPAYGVFPVVRGVDGRWRWYGDGVDLAAPAR
                     LSEPFPVTGPDPESLAALRAREPLEEDFEDVEEFDRVYEAWDARMGDLLWAEDRTAGAL
                     CLCHLGCALRQWLVVSGPEAGRMWNDARVDDEDLRPLTGEDGTPLTFVDWYLEWLREAS
                     RAVAVRS"
     misc_feature    20292..20307
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.15"
                     /tool="antismash"
     misc_feature    complement(20381..20394)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.6"
                     /tool="antismash"
     misc_feature    20413..20422
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.85"
                     /tool="antismash"
     gene            20470..20739
                     /locus_tag="NOSIN_RS11140"
                     /old_locus_tag="NOSIN_10995"
     CDS             20470..20739
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017536284.1"
                     /locus_tag="NOSIN_RS11140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_10995"
                     /product="hypothetical protein"
                     /protein_id="WP_077690669.1"
                     /transl_table=11
                     /translation="MTRPWEADPDARMIRRLGRSPQALGNTNNVQGCPDIWELENGDIA
                     VIGRDLTAHYADLLPSEAAIDDDERLVVIPRNVLISAKADIPDA"
     gene            20732..21340
                     /locus_tag="NOSIN_RS11145"
                     /old_locus_tag="NOSIN_11000"
     CDS             20732..21340
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017577689.1"
                     /locus_tag="NOSIN_RS11145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NOSIN_11000"
                     /product="DUF6879 family protein"
                     /protein_id="WP_077690670.1"
                     /transl_table=11
                     /translation="MLDVLTGLRGDLLDLDAYDEDFAHRFGALRGADAWKLERIQAFHE
                     PGNPSWTRYRAGEVHESLRMLEEDRSGLVEMFSGLERRGSRVLRVRVVEWPLTPYLHWE
                     LHSLHVRAQCGEHVRVVGPEAVAHLEGRGTVPEVLTLGDEVTYRIRYDERGVLAGSVRH
                     TDPGITARCREEIAALYRGAEPLESYFPREVALSEAPRA"
ORIGIN
        1 ccaggccgat gacgtactgg ccgctggcca tggtgatccc gaaggcgagg ttgggtcccg
       61 ccaggctcgc ggcctcacgg aacctcggca tgggcttgcc caggaagagg ctggcgaaga
      121 ccaccgagat gagcaggccg ggcagcgcgg accagaccga catcacctcg gtgccgaaga
      181 gtccgccctc ggccgcgcgc tcggcgaagc ccccgcccag gccccggtcg gccatccagc
      241 ccatgaggct cccgaagacg tcgggcccca ggagcagcgc gataccgccg ccgatgatcg
      301 aaccgggcag gtacagcttc tgggtcagct tccacttgac ccggaccagc ttcgatacca
      361 ggagcagcac ccccaggagc aggagtgcga ggccgacggt ctcaggggtc atctctacct
      421 ctcgtggtca tccggtggaa gaggcgcgca cacccggacg cggggggcgt cgaacgaggg
      481 tgccgcctcg gttcgggccg cggcggggag gtagggacac cacggacctg gagtgaccgt
      541 ggcgcgacga tcacccgcgg catcctacac acgccgtgac agtggcggac ctctcagcga
      601 cacggcgccg ggatggcgat gatcacgccc ggcgagcgtg cacgccgctc gacccgtccg
      661 acgggccggc tcgctccgag gcgggcgaac cgcatctttc cattgacaag atgagtgcgc
      721 gtggaggaat atttccagtg gaaagattcc gcgccgggcc cgggaggaaa ccccatggca
      781 cccctcatcg tcctcgtcgg cgtcaccgcc ctgctgctcg ccctcggcgc cgcgggcgta
      841 cgccccctgc ggtcgtggcc gccggccctg cggggcgggc tcgccgccat gttcaccctg
      901 accggcgtgt cccacttcgt aggcatgcgc gaggtgatgg tggcgatggt cccgcccgcg
      961 ctgcccgcac ccgagctgct ggtcaccgtc accgggatcc tcgaactggc cggcgcggcg
     1021 ggcctgctgt gggcgcggac ctcgccctgg gccgcggccg gactcggcgt cctcctggtc
     1081 gcgatgttcc cggcgaacgt tcacgcgatc accacccagg tgagcacggg cctgaccgac
     1141 aacctgccgg tccgcaccgc gatgcaggtg gtgttcctgg ccgcgacgct cgccgtgctc
     1201 gtccaccacc tgcgcgccgg gcgccgggtg gaccccgtcg gcaccgccac cccccagcga
     1261 cacaggaccg agtccaccga acaaacctaa gaccgcgccg ggtggatccc gtcggcaccg
     1321 ggcaccggag cgctgtgtag ggtggccgcg aaccggcgcc gacacgtgag gacggtggga
     1381 tgagcctgct ggccatcagc gacctgcacg tccggcacgg cgacaaccgc gccttcaccg
     1441 aggacctgcg accggactcg gaggacgact ggctcctggt ggccggggac gtcgccgaga
     1501 cgaccgccga catcctctgg gcgatggaac tgctggccga ccggttcgcc accgtggtct
     1561 gggtacccgg caaccacgac ctgtggaccg tgcccgcgga ccccctccag ctgcgcggac
     1621 aggagcgcta ccagtacctg gtcgaggccc tgcgcggcct gggcgtgcac actcccgagg
     1681 acccctaccc cctctggccg ggccccgacg ggccggtcgt cgtcgccccg ctgttcgtgc
     1741 tctacgacca caccttccgc cccgagggca ccagcaccaa ggaggaggcg ctggccgtcg
     1801 cccacgaggc gggggtggtg tgcaccgacg agtatctgct ccaccccgat ccccatcccg
     1861 ggcgcgacgc ctggtgccgt gcccggctgg agtacacgcg cgcacggctg gactccctcg
     1921 acccggacct gcccacggtg ctggtcaacc acttcccgct cgtgcgcgag cccacccgga
     1981 tcctgcgcta ccccgagttc gcccagtggt gcggcaccga ggccaccgcc gactggcacg
     2041 tgcgctaccg ggcccgcgcc gtcgtctacg ggcacctgca catcccgcgc acgatcgtgg
     2101 tcgacggcgt tccccacgtc gaggtctccc tcggctaccc ccgggagtgg ggtgcgcgcc
     2161 cgctcccgcc cgaggggccg cgccgcgtcc tgccgtaggg ccacgggact tcgggctccg
     2221 ccgcccgcca tccgccgctt cgcggatcgg ggcgcgtccc ggtcggtacc gtccggatcc
     2281 ctcacggccc gttggtgtgt ccgccccgca aggttgaggg gacctcacgg ggcggaccgg
     2341 ggggaggggg gaggggattg cctgcacgag tcaaccggac ccgctggctg cgggtgcctc
     2401 ttcgaatctg atgatcatcc tagaagaggg cattcgaaat gcgcaaggga gaccagattt
     2461 ttttccacac gaagcgagaa aaggctgtcc aatacctacc tagggactta tctgatgcga
     2521 caacggcgga tacaagctcc taccctctcc cgaacactca cgtaaggctt tgaccagtgg
     2581 gaacccgcgg gcggtaacca ccgtgaggcc ccgaacgccc accgcagtga ttctcctgaa
     2641 ttcaggacat gttgtgacgt gcattcccca cggggaacga cccgcccggc agagcccggg
     2701 aggatagccg gaaagtttcc ggacgaccga tgggggcgcg ccgtccggct gccgccccgc
     2761 ccgagcggtc gcccgggcgg ggcggcagca ccgcgggaag gcgctggtca ggccagtggg
     2821 ttcaacgggg ccggcggggg cggcggggtc agcgctcggg gtcgccggcc cggctcaggc
     2881 gcacggcctc gtcctgccag tggcgcaacc gcctctgcat gcggttctgg ttgtgggaca
     2941 gggcggccat ggcgaaggtc gcgaccagga cggccccgac gaggaagaac gtgatcgcgg
     3001 tagcggtgac caggatgacg gtgacgttca cgacgcacac ctccgatgat cctttgtttc
     3061 ttctgcggtg ccgtcacgca gacgggaaaa gaagtgggaa acgcgtcggg cccgagaccc
     3121 ggccagtggc ttgggaggct aagctgggac ctgggttcgg gacctcttgc ggaggacccg
     3181 actcaaggtt aagctaaacc cttcacaccc ggaaatgtcc attttgggga ctattctcgg
     3241 ataagcgcac atccagggga cgtgaagggt acatccgatg tacgtcagca ttccccatgc
     3301 acagggagag tacgggcatg ccctgagaga gctgcgccgg gggatcggct gcacgccgga
     3361 caggctttcg gagagcaccc ttctcgaacg cacccttcgg gagaggatcg agtcccgggg
     3421 ggaagaggtc acggccgacc gcctgatcat ggaactcacc cacctcatag actccatcgg
     3481 cgatcccaaa ttccgtgagt ccctgcttgt ggcgctgcgc ctggacctgc ggtaccggca
     3541 gcgcaccctg atggaacgcc gcaggaacta caaccgcgac ctgaggaatt caccggactc
     3601 cgagatgcgg cgcctccacg tggacaacct gcgcaccatg gaacggcgcg agaacaaggc
     3661 gacagaacag gtcgcccgct acctggacga cggcctccag gtgtccgaca gggcccatct
     3721 gcgtgatttc ccgctgcgcc cgatcgcgcc ccagggagag ctcgcggtgg aggcgatctc
     3781 ctactcgtgc gccttctccg acaccggcgt cctgcggacc caggacgtca cgcggtgggt
     3841 gagggcgaca tcaccgcaga ccagccccga actgacggtg acccaccggt acttcaacga
     3901 gaacaaaacc ggcctgttgg atatcgagag cctctacggc tgccgtgtgg tcgagcgctc
     3961 ggagaccgtc agcggcgacc tcctcgccag gatcagcatc cacaaggacc tcgcccccac
     4021 ggacggcgtc tactccttcg gctcccggat cagtgtgaac agcgacgcca cgtgcaggcc
     4081 cgtcatcgtg tggcgtcctc gcacttcctt caccaggcgc atagagttcc acctcaggtt
     4141 cggagaaccg catcttccgg tccgcgcgtg gtggttcgtc agttcccagg aggtcgaagg
     4201 ggaactggag cctccgccca gcgagggtcg gcacctggag cacctcgacg aagggaggta
     4261 cctctacagg atattcgaga acgaggacat cacacccgac ctgcgttacg gaatatcatg
     4321 ggtgtggccg ggatagtaca tgcttcgcgc aaaagacccg caaaagagag aacgtcaatg
     4381 gagaacgatg gctgagtgcc gctgagtggc cctaggcgcc accggtgctt ttctgtgcgc
     4441 ccggatccct gaccggaccg ggcgcctgga tgcccggatt cagccctctc cgttgtccat
     4501 gttccccttc cccgggcggg ccctcgccag cctaccggcc cgtccacaag acacggtagc
     4561 caaatccatc tcgcattcca agagtcccgg ccagatcaat attgtttatc ccattgttct
     4621 tgggacgaag gtttgaaaag gatgcacggc gggaatccta tttcttacca gcggaacccg
     4681 aagccttctg cgcgggcttc gctgcttcat cacccgcgtc aacagccccg tcacccctgc
     4741 ccgacatgct cggaccggga atggaaaagc ctcggtgttc gccgagtgcg ctctcgaacg
     4801 catactcgga cgaaccccgc gagaaggccg gccactccga ttcgtgatgg ccggtgaccg
     4861 attcggggca ggccccgctc aaccgctctc gcgatcgcgg tggctgttcc gggcgcgacg
     4921 gcgaccccgt ccatggtcgc cactgagagc agcccggcca cgttcacgcc ggttcggacg
     4981 tcgccttggg gatcaccggt accgccggcc acccacggct cggccaggag agggcgctcg
     5041 ggcccgcgaa ggctcagggc ttgcgggcca ggccgcagta ctcgtccatc tccctggccc
     5101 accccacctg tgcgggctcg ggccgccaca gcgggcagga gaccacgccc ggctccacca
     5161 gctccaggcc gtcgaacagg gcggtgagcc gctcgggggt gcgcaggtgg tacaccgccg
     5221 acccggcctc gttccaccgg cgcaccgcct cgaccatcgc ctcccccgtc accgcgctgg
     5281 tgctgtgcac gatcgccagg aagctgcccg ggggcagcgc gcccatgagg tggtccagga
     5341 tcgccctggc ctcggtgtcc tcgcccacga agggcaggac gccgaacagg gtcaccgcca
     5401 ccggacgccc caggtccagc gtcctcgccg cctccgccag gatggccgcg ggatcgcgca
     5461 ggtcggcgtg cacgtagtcg gtggcgccct cgggcgctcc gctcagcagg gcgcgcgcgt
     5521 gggccagcac cagcgggtcg ttgtcgacgt agaccacccg tgcggcgggg ttcgcggcct
     5581 gggcgacctc gtgggtgttg ttggcggtgg gcagaccggt gccgatgtcc aggaactggt
     5641 cgacgccctc gcttcgcacc aggtgggtga cgacgcgcat gaggaagctg cgggtggcca
     5701 gggcgatgtc cacgatctcg ggcaggaccg cggcgatctg ctcgcccgcc tcccggtcca
     5761 ctgggtagtg gtccttacct cccagccagt agttccagac gcgcgccgag tgcgacaccg
     5821 tggtgtcgac gaggggtggg gtggtcacgg tgctccaggg gtgaacaggg ggcgaggggc
     5881 gaacacccac aacctacgag ccggaacaga acgcgcgcac cggcctttgg tccttccgag
     5941 gacggcacgc gggcacgcgt cccgggacgg gtgtccccgg tcgttcaccg ggcgtccacc
     6001 ggtcctccac tccgtcggcg gtacccggcg gcggccgtcc ccctcgtgga gacggccgct
     6061 tccggccatc gggcgccgtg gcctggcctt gcaccggcgg agcgaaacgg ggagggttca
     6121 cgacccccgt tggtcacagg ggccgtacat catgaggccc atggaacgct gcgatttctg
     6181 tgaactcccc gtcggcggcg gatgcgcgtg ctcgctcggc cgggacggcc agggcacccg
     6241 cggtcagggc gccggcgccg cgacggggga cgcgcacctg ccggggaagg ccatcctcat
     6301 ctcgccgagg ggcgtggccc accggcccgg ctgcctgcac cagtccgagt ccgaggtgaa
     6361 ggcaccgctg tggggctgga tcaccgatcc cgaccctcgg ttgtggcgcc gtctcagcgc
     6421 gggatccccg gcccgggcca cgcacggcaa caccgaacgc gtcgccacac gccgctgccg
     6481 gagctgcgac gcctgagggc acgggtccca cccgcgaccg gcggctccac gccgccgacg
     6541 ccccctgccg ggtgcggccc caccgcccgg ggaccgcccc cggcgttccg gggctgcccc
     6601 gggatgcctc gggccgcccg cgtccgcttg cggccggcta ccccaccggt cgtccacggc
     6661 ctactcggcg cccaggaccg cgctgagcag accgggcatc ctcgcctcca ggtcgtcctc
     6721 gcgcagtcgg ctcatgcgcg aggtcccctc gtagtactgg cggatcaccc cggcctcgcg
     6781 cagcacccgg aagtggtggg tggaggtgga cttgctcacc gggaggtcga aggcgataca
     6841 ggccatgtcg tcgtggcccc gcgccaactc gcgcacgatc cgcaggcgta tcgggtcgga
     6901 cagcgcgctc agcaccgact ccagacggat ctcgtcgcgg tcggggtggt ggagccgccg
     6961 ctcgggcacg gccttgttcc tggacatgct ctgacccttc gtcggcgcgg ctcacatcac
     7021 aaagtacgag cattgccgta gtttgacaag cttcgtagta cgacatgtat cgtacgagcg
     7081 tcggccccac ggccgccacc gacgacgccg agacgaagga cgcaccgtga gctccttgtt
     7141 caccccgttg accctgcggt cgctgacgat ccccaaccgc gtgtggatgt ccccgatgtg
     7201 catgtactcg gccgcttcgg agggggatca ggccggagct cccaccgact tccacctcgc
     7261 gcacctggcc gaccgggccc tcggaggcgc gggactggtg atggccgagg ccaccggggt
     7321 gcgccccgac gggcgcatca gcccctggga cctgggactg tggaacgacc agcagcagga
     7381 ggccttctcc cgtgtcaccg ccgccatccg ctcccacgga tccgtcgcgg ccgtccagct
     7441 cgcccacgcc gggcgcaagg cctccacgaa caggccctgg ctcggcggcg gccacctgac
     7501 cggggccgag ggcggctggg agacggtctc ccccagcgcc gaggccttct ccgggctgtc
     7561 gaccccccac gagctgaccg aggcggagat cgaccagctg gtggcggact tcgccgcctc
     7621 ggccgagcgc gccctggccg ccggcttcca ggtcgccgag gtgcacgggg cgcacggcta
     7681 cctgctccac tccttcctct cccccgcggc caaccaccgc accgacgcct acggcggcgg
     7741 cttcgagaac cgcacgcgct tcccgctgcg ggtcgtggag gccgtgcgcg aggtctggcc
     7801 cgaggacctg cccgtgttct tccgcgtctc ggccaccgac tggctgagcg aggacgccgg
     7861 ggacacccgc cggggctgga ccggtgacga caccgtcctc ctggccaagg agttgcaggc
     7921 ccggggcgtg gacctgctcg acgtctccac cggcggcgtg gtccacgacg cccggatccc
     7981 cgtcggcccc gactaccagg tgcccttcgc cgcgcgcgcc cgccaggagg ccggtgtccc
     8041 cacctccgcc gtcggtctgg tcaccgaccc ccgccaggcc gaggagatcg tcgcctcggg
     8101 ccgcgccgac gcggtgatgc tcggccgcca actgctgcgc gagccctact gggcccaccg
     8161 cgccgccgcc gaactgggcg cgcgccccgc gtggcccgag cagtacggct acgcggtgta
     8221 ggtccacggc gggtaggacc gaccagccca tcgaccgccc ggtgcggggc cgcccgtttc
     8281 ggccgggcgc cccgcaccgc cgtcaccgca cgggacgcac cgtccgcggg ggcggagtca
     8341 ccattcgggg ctcccggtca gttcgcgcac cgcgggcagc actgcgtcga ccaccgtggg
     8401 gaaccacgcc gagaacggca ggtccccgca catgcgctcc agttccgcgg agtcggcgaa
     8461 cgcggtctcg gcgacctcgt ccggatcggg gcggagccgg ccgcgcacca ggcccacgaa
     8521 gaggtggttg tactcctgct ccaccagccc ggagtcgggg tccgggtggt tgtaacgcac
     8581 cgtcccggcc tcacgcatga gcgcgggggc cgtgcccagc tcctcacagg tgcgccgggc
     8641 ggcggccacg aagggcggct ccccggggtg cgggtggccg cagcaggtgt tggaccacac
     8701 ccccggagag tggtacttgc ccagggcgcg gcgctggagc agcaggcggc cgcggtcgtc
     8761 gaagaggaag accgagaagg cccggtgcag cctcccggga ggcaggtgcg cggagatctt
     8821 ctccgcggtg ccgaccgtcg tcccgtcctc gtcgaccagt tcgagcatga ccggcgcgcg
     8881 gccgggggcg aaggcggctt ccgggtcggc caaaggtgcg gtggagcggt ggtcggcggc
     8941 tggaccggtg ggcatggacg tcctccacgt tcgaacgttc gacggcggat gcggggtcgc
     9001 ggcggcgcgg ggccgcgccg ccgcgcgacg gctcagacgc ggtcggccgc gatgagcagg
     9061 tagtggaagc ttccctcccg gtacgcggtg aggaaggggt cctcgatccc ggtggccacc
     9121 gaggaccgcg cccgcagctc ccagtacggg atcgtgctct cggtgaggtc gacgacctcg
     9181 atcgggacga ggccgttggc cgccatcgcc ctgaagtacg cgctgcgggg gtggatgttg
     9241 caggtgtagt gctcgtcgat gcggctgacg gccttggagc ggcctccggt gacgtcgttg
     9301 tagcagccgg tgatggtgac gtagcggccg ccgtactcca gcaggcgggc gtgctcgcgg
     9361 aagaggtcga acaggtccac gtacatggtg gactcgttgt tccagctggc gcgcagggag
     9421 cccgcctcga aaccggtgtc gagcatgttg cggaagtgga accgcacccg gtcggccaca
     9481 cccctctcct cggcctgccc gttggcgaag gcgacctgct gctcggagat cgtcaccccg
     9541 tccacgtggc agccgaagcg ctggtgggcc atgaagctgg tgccgccccg ccccgagccg
     9601 gtgtccatga tccggtcgtc gggcgagatc ggccccaggt ggtccaggag caggttcgcc
     9661 tgcgcggtct ccaggcggtg catctcccgg atgacgcgct cgtcgcgggt ctcctcaggg
     9721 ccctcgagca cggagtggtc gtagtcgccg atcccgtagt ggtggtggta caggccgtcg
     9781 acgtcgccga ggcggatgtt gacggggtcc ttctcggcgt tccagtacgc cgccacggac
     9841 ttctggtagg cggtgcgcag gacgctgggg gccatggtct ctgtcatggg agggagctcc
     9901 ttgtcgtggt gtcccggccg gtcggggccg ggtggagtgc gggttggggc gcgtcggggc
     9961 ggcgggcggt tcggggcggg ccgtgcggac cgcgccccgc tcaggagccg ttcgcgccgt
    10021 ggtagcgggg gctgcgggcg tgccattcgc ggctgccgcc gagccaggcc cacaggcccc
    10081 acaggaagcg gcgcagctcc ggtgagccgc tgagcgccag tgcggcggcc tcggcctcga
    10141 aggcgtgcat cagctcgtcg tggacctcga cggtgcgctg gacggcctcg ctcagcgagc
    10201 agtcgtcctc cgaggcgatc agcctgggca ggctgaggtc ggtgacgtcc tccttgccca
    10261 tcgagtacag gtcgttcacg atcacgctcg cgcttcccgc cagggtgaac acgcggcgca
    10321 cgctcggctg ggcgaactcc gcccagggga gctcgtatcc ggcgaccggg tcgatgagcg
    10381 ccatgcacgg cacgaagctg ttctcgtgcc ggtgcatgag gaactcccac accggcggcc
    10441 tgtgcccggt ggccagccag acggcctcct ggttgtaggc cacgaacatg atcgccagct
    10501 cgtggcggag cctgcgcacc tgcgccgccg tggcgtaggc gcccaggttg gccaggctgg
    10561 agcggagggc gaccatcacg gggtccccgc ggacgacctc ctccaactgg ggcgcgtagc
    10621 gccgcggcag gtgggcctgg tcgatgaccg agtgcgcgat cgccaggcgc tgtccgagca
    10681 gctccggatg cgcctcctcc gcctcgccgt cgacgtagtg gtcgtccacg gaccactcgg
    10741 ccagggcgca cttggccgcc gccagcagcc ggtcggggtc gtcggtctcg gggtgggcga
    10801 gcatgatgag gcgcccgaac ccggccgcgc ggacgcggtc gagctggccg gggtagacac
    10861 ccacctccgc ggcccactcg accagccggc cgtcgacctc gtcccccagg gcggggtcgt
    10921 cgcgcatggc gggcgggcag tacagcgccg ggacctgttc gccccctccc cgctcccccg
    10981 gcgagccgtc gtcctccgga cgcttcgtgc cgcctcgcgg gcgggcggcg ccggtcgcgg
    11041 gagctccggg aaggcgtgct cccacgggat gggcggggat acccggtgcg atgcccgccg
    11101 cggcggtgct cgggctctgg tcggccgggt gcggcgagga cagccggagc cggagcgccg
    11161 acgtcccggt ccccgagcgc ccgacgggca gccggggcgc gggcggtgtc cgcggggccg
    11221 gtgcggacgc gggcgccagc aggtcccgtc tccccgggcg ccgcgggtcg cggagcaggg
    11281 cctccaccag gcccaccacc tccggggagg cggcggtggc cggtgtcgtg gacagcggtg
    11341 acaccgtctc agacctcctt ccctgacagt gcccggatct cagccacgcg ggtggacctc
    11401 ggcgttctcc aggatcccga cggcgtcggg gacgagcacc gcggcggagt agtaggtgct
    11461 gacgaggtag gagatgacgg ccctgtcgtc gatgcccatg aagcgcgcgt tgaggccggg
    11521 ctcgacctcg tcgggcagcc cggtctggta caggccgatg acgccctcgt tgtcctcccc
    11581 ggtgcggacc gcgatgatcg acgaggtctg gtgctcggag accgggatct tgccgcacgg
    11641 caggagcgga acgccgcgcc acgcgggcag gtggtggccg ccgacctccg cggtgccgat
    11701 gttcagcccc cgcttgttgc actccttgcc gaaggccgcg atggccttgg ggtgcgcgaa
    11761 catgtactgg gtgttgcggc gcatgctcag caggtcgtcc aggtcgtccg gcgtgggcgg
    11821 cccctcgtgg gtctggatcc gctgcttgaa ctcggtgttg tgcagcaggc cgaactcgcg
    11881 gttgttgacc agttcgtgct cctggcgctc gcgcagggcc tggatggtca gtcgcaactg
    11941 ctgctcggtc tggttcatcg gcttgttgta gaggtcggcg acccggctgt ggacccgcag
    12001 cacggtctgg gccacgtcca gctcgtactc gcgcggtttg aggtcgtagt cgacgaaggt
    12061 ggcggggagt tcggcctcgc cgacgtggcc cgacgacagg gcgatctcgg cctcgccgtg
    12121 cttgttctgc cgctgctcgg gcagggacag gtactcctgg acgtgggcct ggagggtggg
    12181 cgagtcgtcc aggatcgcga tgaactcgcg ccggggcatc tccagcagcg tgcccgccgt
    12241 cgcggccttg acggtgaact cccaccgggg ttcggcgtcg agcaggtagc ggtcgccgaa
    12301 cttgtcgccg tcggccagta cgcccagcca gttggtgtcg ccgtagtggc cgctgctggt
    12361 cttgtgcaca cgtccgtgcg ccagcaggta caggtggtcg gccgaggtgc cctcctccgc
    12421 cagcacctgg ccgggctcga agtcgcgctg gacgaagcgg tcggccaggg ccgtcagcac
    12481 gtccacgtcg tcgaagccgc gcagcagggc cagctcgccg agctcctggg ggatgacccg
    12541 gacctgcgca ccggtctgcg agaactcgat gcgtccgtcg ccgatggtgt aggtcagccg
    12601 ccggttgacc cggtaggcgc cgccgtcggt gtgcacccac gggagcatcc tggtcagcca
    12661 gcgggagctg atcccctgca tctgcggaac ggacttggtc gtggtcgcca ggttgcgcgc
    12721 ggcggcggtc cccaggctct gttgcttgcc gcttcgtatc tcgggagctg aatcgatcga
    12781 catccgccgg gtctctcctg tgtggtcgcg tgcccgctcc gccgggtctg aggggactcc
    12841 gcggagcgga tcgggaggaa aaggggtcac gcctgttcgg atacgtgggc tgaccagggc
    12901 cgttgacgcc caggcagcgc tccgtaaacc gttgacaacc ctaggaccgg ccattcggga
    12961 cgtgcaagat aatcacgatt cccattggaa tcgggagagg aatgcatgtc ccataactac
    13021 gttggtcctt atcgaccacc aggaggagtg tcctcgcgcc cgcaggcacc tcctgttctc
    13081 ttatcgggac cctgaccagg aggaacaaac ccgcactcac ccgcgccggg cgcaccgact
    13141 ccaggaactc ccccgtgaat gaattccatg aaatcgggac atgtcgtgat gtgaattgtt
    13201 catgaagggc gccccgataa gctgattcac ggtcacgtaa ggaaaggatt acggtcagcc
    13261 gatgcgacgg cccgaagccg cggcggggct ccgttcgccc ggtcccggcg gtccccgccg
    13321 aacgcgtcga ccgggccgcg ggtgcgtggt gaggccgtcc ggaccgcgtc acttcggcgg
    13381 ggaccgaagc gacacggccg taacgtcccc ccatgacctc accagcagaa cgcgcaggcg
    13441 ggcacaccgg cgtccgcgcc gcccggcacg actccggccg catcccgccg ggccgccccc
    13501 ggaccgaccg gtccccggag gagccggccc ccggtgagcg gttccgcgcc ctgcacctgg
    13561 agggcgaccc actgctcctg cccaacgcct gggaccacgc gtcggcggcc gccctggccg
    13621 cggcggggtt ccgcgcggtg ggaaccacca gcctgggggt ggccgcggcg gccggacttc
    13681 ccgacggaca ggggcacacg cgcgaggaga cgctgcggct ggcccgcggc ctgtcccggc
    13741 tggacgtgct ggtcagcgtg gacgtcgagg gaggcttcgg cgggtcgccc gcacaggtcg
    13801 ccgcgctggc cgccgaactg gagcggacgg ggatcgcggg gatcaacctg gaggacggcc
    13861 tcccggacgg cgggctggcc gacgtggggc gacagcagga ggtcgtccgc gcggtgaggg
    13921 atgcggcgcc gtcgctgttc ctcaacgccc gcaccgacac gtggtggctg cccgggcaca
    13981 ccgggcagac ggccgaccgg gccgccgcct acgaggaggc cggtgccgac ggggtgttcg
    14041 tgcccggcct gcgcgacgag gaggagatcg ccgccctgtc cggtgccctg cgcgttccgc
    14101 tcaacatcct ccactccccc accggtcccc cgccgcgggt cctcgccgag ttgggtgtgc
    14161 gccgtgtgag ctgcggttcg ctgctctttc gcgccgccct ggccggggcc ctcgccgcgg
    14221 ccgaggcggt ggcgtcggga ctgcccctgc ccgagggcgt tccgggctac gacgaggtcc
    14281 aggccctcgc ggaacggttc gcggcgcctc ggggacgatc ggcggcgggg tagggaatcg
    14341 tccgttcggg ccgcttccgt gggagaccct cagaagtcac agcaggaaca gcattcgcag
    14401 cagctacagc actcgcagag gttgcaccag gcgtcacgcg gcctacccgt ccacggcccc
    14461 gggtgggggt cgcggcagca gaactggcag gtgcagcaca tgaacagcgc ggccgcgcag
    14521 cccgccagga cgccccgcgg cttgggcgaa ctccggagtt cgggggtgtc gcacgaacag
    14581 gaggcacagc agttgccctt gcctccgttc ccgcctggac cggagccgtc cccgtgtccg
    14641 ccgccgtgcg gcgcatcgtg gctcccgccc ccgttccgtc gctcctggtg gaactgctgc
    14701 tggtggtggg ggcggtgggg gtgattccgg tagtgctcgt tctgttggtg gcccgggttc
    14761 ggatacccgc cgtgggcgaa ggcgcgctcg acggctcggt gcagctcccc caccagcagc
    14821 gcgcgggcca ggcggtcgtc ggcgaactcg gcctcctcca acgccggccg gacgcccagg
    14881 accgcgtcgt cgcacagctc gcgggcccgg ccgatcccgg tgccggtggc cgtgagcggg
    14941 ttccaggcgt tcctctcccg gtcctcctcg cggtcctcga ccgcgtccag caggtgcgcg
    15001 acccggccga acaggcgtcc cgcctcgcgc agcggttcga cgttggcggg gcggcccgcc
    15061 aggaccgcgg tgtgcgcgaa cgcctcaccg gtggcctcct cggtcggccg ggtcaccgtc
    15121 aggacgtcgg tgcccgggcc cgccgccagc tcggcctccc gctgccggtc gaccaccgcg
    15181 accagctcgg ctccgtcgaa cccgagcccc gcgcccgcct cccgggcctc gcgccgccag
    15241 cgctcggcca cccgcccggc gagcgcgcgc acgccgcggc gggcgtaggg gccgtcgccg
    15301 tcctcgatgt ggtcggcgat cttggccgag gccagcatca gcgacaccga cgccgccaga
    15361 tgggcgccgg agccgtcggc gacctcggcc ccgcgcatgc cgcgcagggg gcagcggccc
    15421 gcccggcgtg tgccggcgca ctcctcggac tgggccgcgg tcaggaccga caccaccagc
    15481 ccgtcgtagt tggtggcgat ccgggaggcc tggccgtggt cgtcgcgcag tgccaggcac
    15541 agcccgcaca tgtgcgacat ccactcctcg gccagcccgt cggacagtgt gtgccgacag
    15601 ggacgcagga ttccgaacac gggctggtgg cctcctcttt ccgacgccgc cgcggcggcg
    15661 gcgtcgcggg ctggacagga gggtacgacg ccccgagcgc acgggaagtt cacggccgcg
    15721 cgaacgcgtc gaaggcgcgc tgtcggcctc ggggcggact cagtggtcgc ccgtgtccag
    15781 cagtcgctcg aagttccccg cgggacgcgc gcgcgtgggc atggcctcca cgaacggcag
    15841 caactcccgc ctggcgaccc cgtggacccg gcgcagttcg gccaccgggt cggagtgctc
    15901 gtccaccctc aggtccaggt agggataggg atggccggtg tgcacgtaca gcgccgcgct
    15961 ctgtctgccc cgcctgtccc cgccggccgc ctgccccgcc tccagggcgc tcagcaggcg
    16021 ctcgtccatg cggtccccgg caccggcctc gaaccgctcc gccatcgcgt cgagggtgtc
    16081 ggcgccggtc aggatgtttc ccgccaccgc gtatccggcc cccaccctgt ggccgcacca
    16141 cggatgcgtc tgcgatccgg tgtgcgcggc ggcgcgacct ccccggtcga ccacggcgac
    16201 ctgccgcgag tccgcggcgg ggtcggtgcc caggacccgg cgcagcgcgt cctcggcggt
    16261 gtgggaccgc agcagctcca gggcgtccgt gcccagcagc gggttgatca gcgcctgtgt
    16321 cgcgaccgcc cccgcgtccg cgtgggcgaa caccgacagc gcgccgatcg cgggcatccg
    16381 gctgctgacc gcgacaccgc acgttctgac ggcggtgtcg taggcgacga tcgagaaggt
    16441 gcctgcgtac aaccggaacc accctcgggt gttcgggcgc ctggatcggt gcggtgcggc
    16501 gccctcgcca ggggccggga gatcagacgg atcgccggga atgctaccgg acgcggggac
    16561 ggtgcgtgcg ccctcaggcg ggacggtgcg ggacggcacc gcccggcggg tcccagcgcg
    16621 gtggccgcag tcgccccacg agccgtgatc ttgtacttat agcgcatttg ggcgcccaac
    16681 ctcgctataa gtacaagatc atccggggtc ggagcgttcc agtcacaccg gcgacgtgtc
    16741 cggtcagccc gctagcggcc ctccgtcagg aggtcgaagc ggtacaggcc gatcggggcc
    16801 ggtggcggca ggtccggtgc cgaggtggtg tggtcgctcc ggaaggcctg gaggaagtag
    16861 gcgaccagtc ggcgggaggc ggccgccgcg gcctcggagg actccgcgac gacgccgtcg
    16921 ttggccttca tgacgagggt gaggtcggtc cgggcgaagt cggcgcgcag gtacccggcc
    16981 tcctgcgccc tccgtgtcag ggcggcgaag ccccgttcgg cgcgcatgcg ctcacgctcg
    17041 aagtcgacgg ccccggggaa ctcggtgagg aacgcggcgg tgaacccccg gtcggccacc
    17101 tgcatggcgc acaccttctc gatgacggtg cggaacccgc gccacgggtc cggatccgcc
    17161 agggcctcgt cgacgacgcc gacacagtcc gcgagccggt cggcgaagac ctccgtgacc
    17221 agcgactccc tggtgggaaa gcgccggtag agcgtggcca cgccgacacc ggcgcggcgg
    17281 gcgaccgcgg ccatgggcac gtcgaggccg cgcgccgcga acgcctcccg tgcggcttcg
    17341 aggatgcggg cgcggttgtg ccgcgcgtcc gagcgcagcc gctccggccc ggcggcggtg
    17401 tcggggccgg cggggtcggg agcagtggtg tcggaggcgg tggagtcgga ggcggtggag
    17461 tcggaggcgg tggagtcggg gtccatccga gaggaatcgg cagccatacc tctcacatta
    17521 gccagaagtg gacgggtcct tccgttttcg gcgtagcgtg cacgaacggg aacccgcacg
    17581 ggtggtcgtg cggtggctga cgaaggggac ctgaacggtg gatcggatac gcgcggccct
    17641 gtacgaccgg tacggcggtc cggaggtgct gtacgagggc acggtggcca gacccgacac
    17701 ggggcccggg gacgtgctgg tgcgcgtcca cgccgccagc gtgaacggcg gcgagctcct
    17761 gggccgcgcc ggcgggattc gcctggcgac ctggctgctc gacaggggct ttcccaagcg
    17821 gaccggaaac gacttcgcgg gcgaggtggt cgagaccggg tccggcgtct ccgggttcgc
    17881 gccgggggac cgggtgtggg gcgcgctgcc ccggacgttc ggcagcgcgg ccgagttcgt
    17941 ggccgtcgcg ccccggcagt tggccctcgc accagccgac ctgaacctgg tcgaggccgc
    18001 ggccctgccc gtcgtcggca cgacggccgt caccgcgctg cgggacaggg cccgcctcgc
    18061 cccgggcgag cggctgctgg tgcggggcgc gagcggcggg gtgggcagcg tcgccgtcca
    18121 gctcggccgg gcctacggcg cccacgtcac cgcgctggcc ggggccgagc acctcggctt
    18181 cgtgcgggag ctgggcgccg acgaggcctt cgactacgcc ggcaccggtg ccgccgacct
    18241 gccgccgttc gacgtggtcc tggacacggt cgggaccggg ctgcgggcct accgcaggcg
    18301 gctgaccggg aacgggcgca tcgtggcgat caccttcgac agcgggcgca tgctcgcctc
    18361 gctctcctac atcgccgcct cggccgtctt cggctcgcgc cgtgtccgct tcttcagcgg
    18421 cgaccccggg cacgagctct tcgccgaact gacccgcctg accgagtccg gagccgtccg
    18481 tcccgtcgtg gacaggatcc tgcccctggc cgagatcgcc gaggcccacc gggcgctgga
    18541 ggccggtggg atccggggca aggtggtggt cagcgtggcc ggcccgggcg cctgagagac
    18601 cggacgcctg agagatgggt gcgcgccctg cgcggaccgc gtcgtcgcgc gttccccgaa
    18661 gcaaccgccg gggaacgcgc ggtccgcacg caccccggaa aaccgggtgg tgcggagcga
    18721 ccacgcgggg gacactgtgg actccccgag cccaggagag cccgtgtcca ccgaccacga
    18781 gcgcccgcgc ccactgccac ggccgatcac cggcgtcttc gtccgccacc tgctgcatac
    18841 ggcctgcccc cgttacttcg ccatggtgtg ggccgacttc gaaccactgc gggacgacgg
    18901 tacgggcgag gccttcgcct tcgtcgacga tctgcccgac cggtgccgtg agcctgggga
    18961 gcccctcccg aaggagttcg tccgcgcctt caccgagggt gcgcgggaag tctgggagaa
    19021 ctcgggcggc gatcggcccc tcttcgccgc ccgcgtggtg ctgcgcgacg ctgtctggca
    19081 cgacaacgac tccaatccac agagcttccg gatggcgggc cgtctggccg ctcgggaggc
    19141 cctgtgctgt gtcgccgagg gccgcgagcc gcgccaggcc ggacgcagcg ggcgttcgga
    19201 cagccccatc ccgccgatgc ccaggacgct gccgcctccc gacccggccc cgcccgcctg
    19261 agacggccgg ttccgtcgcc cgcgaggcgc cgcccgtggg agcgggcggt acgcggcccg
    19321 tccgtcagga ccggaccgcc acggcgcggg aggcctcccg cagccactcc aggtaccagt
    19381 ccacgaaggt caggggcgtt ccgtcctcac cggtgagcgg ccggaggtcc tcgtcgtcga
    19441 cacgggcgtc gttccacata cgcccggcct cggggccgga cacgaccagc cactgccgta
    19501 gcgcgcagcc cagatggcac aggcagagcg cgccggccgt ccggtcctcg gcccacagga
    19561 ggtcgcccat gcgcgcgtcc caggcctcgt agaccctgtc gaactcctcg acgtcctcga
    19621 agtcctcctc caatggctcc cgggcccgca gtgcggccag ggactccggg tcgggcccgg
    19681 tgaccgggaa cggctccgac agccgcgccg gcgcggccag gtccacgccg tcgccgtacc
    19741 accgccaccg gccgtccacc cccctgacca cgggaaagac gccgtaggcg ggtccggcac
    19801 cgcccgcgcc cacccggagc aggaactccc ggtacccggc gggcagccgc gtccccaact
    19861 gtccctccag ctcggccagt tctccgtgcg tcagcgggtc cagcagctcg aagccgtggt
    19921 ggcgggctcc gaacacctcc cccgcgcccg gcgcccgccc cagctccaac acctgctcgc
    19981 ggactcccgc ccacacatcc gtactcgtgt ccatggcggc atcgtaggaa ccgccggaga
    20041 cagtacggcg gcggcggacc ggccggggaa agcgaaccgg cctctttcgc gcaccggcgg
    20101 atccgaggtc caccgttccg ggaaaaggca tggctcacgc aattcggcgg cgccgattcc
    20161 acaggtcggc accgccgatt catgtgcgta ttcctgtgca tattcacgtg caccaggaaa
    20221 tcatcccgaa cattccatgc acgtcaccca tgacaactcc atgccatcac ggcacagcag
    20281 gtcagagcct gatcaacacg tatcaacgga tgcattccac atgaaatccg gaactccatg
    20341 aacacactcc gcatcgcaca cacgaccgca tccaacagac acataatagt taccggacat
    20401 gattcaccgc catgttattt tctcctcagt acaccttccc ccgattcggt gtgcgcggaa
    20461 aggacagcaa tgacacgtcc gtgggaggca gaccccgacg cacggatgat ccgccgcctg
    20521 ggccggtcac cgcaggcgct cggcaacacg aacaacgtcc aggggtgccc cgacatctgg
    20581 gaactggaga acggtgacat cgccgtcatc ggccgcgacc tgaccgccca ctacgccgac
    20641 ctgcttccct cggaggccgc catcgacgac gacgagcgac tcgtcgtcat cccgcgcaac
    20701 gtactcatct cggcgaaggc ggacatcccg gatgcttgac gtcctcaccg gcctccgggg
    20761 cgacctcctg gacctggacg cctacgacga ggacttcgcg caccgcttcg gggcgctgcg
    20821 cggagcggac gcctggaagc tggagcggat ccaggccttc cacgagcccg ggaacccgag
    20881 ctggacgagg taccgggccg gagaggtcca cgagtccctc cgcatgctgg aggaggaccg
    20941 gagcgggctg gtggagatgt tctccggcct ggaacggagg ggctcccgcg tgctgagggt
    21001 gcgggtcgtg gagtggccgc tgacccccta cctgcactgg gaactgcact cgctgcacgt
    21061 ccgggcccag tgcggcgagc acgtccgggt ggtcggcccc gaggccgtcg cacacctgga
    21121 gggacgggga acggtccccg aagtactgac cctcggagac gaggtcacct accgcatccg
    21181 ctacgacgaa cgcggtgtgc tggccgggag cgtgcgccac accgaccccg ggatcacggc
    21241 gcgctgccgc gaggagatcg ccgccctgta ccgaggcgcc gaacccctgg agtcctactt
    21301 cccccgcgag gtcgccctct cggaggcgcc ccgtgcctga tcgc
//
