LOCUS       NZ_CP014263            26342 bp    DNA     circular CON 05-MAR-2024
DEFINITION  Spirosoma montaniterrae strain DY10 chromosome, complete genome.
ACCESSION   NZ_CP014263
VERSION     NZ_CP014263.1
KEYWORDS    RefSeq.
SOURCE      Spirosoma montaniterrae
  ORGANISM  Spirosoma montaniterrae
            Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cytophagaceae;
            Spirosoma.
REFERENCE   1  (bases 1 to 5797678)
  AUTHORS   Kim,M.K., Srinivasan,S. and Lee,J.-J.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-JAN-2016) Department of Bio & Environmental
            Technology, Seoul Women's University, 623 Hwarangno, Nowon-gu, Seoul
            139-774, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: PacBio SMRT Analysis v. 2.3.0
            Genome Coverage                   :: 72.42
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 01:24:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,031
            CDSs (total)                      :: 4,981
            Genes (coding)                    :: 4,945
            CDSs (with protein)               :: 4,945
            Genes (RNA)                       :: 50
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 39
            ncRNAs                            :: 2
            Pseudo Genes (total)              :: 36
            CDSs (without protein)            :: 36
            Pseudo Genes (ambiguous residues) :: 0 of 36
            Pseudo Genes (frameshifted)       :: 26 of 36
            Pseudo Genes (incomplete)         :: 12 of 36
            Pseudo Genes (internal stop)      :: 2 of 36
            Pseudo Genes (multiple problems)  :: 4 of 36
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:11:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3692079
            Orig. end                         :: 3718421
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP014263.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26342
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="8"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26342
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26342
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16342]"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16342
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(397..1365)
                     /locus_tag="AWR27_RS15975"
                     /old_locus_tag="AWR27_15820"
     CDS             complement(397..1365)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04033.1"
                     /locus_tag="AWR27_RS15975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AWR27_15820"
                     /product="sporulation-delaying protein SdpB family protein"
                     /protein_id="WP_077132094.1"
                     /transl_table=11
                     /translation="MQPLTAFDRYLNALLARNPWTNVYGFVRSLLALGTFCTLLFNDMG
                     TLFRPIAGQTDCPSCMGLAEYSLFCWMGDLETARWVCMTILFLVLIGIYPRFTALLHVY
                     VGFSFMSTAVLVDGGDQVTLVLSGLLLPLALTDPRTWHWSMAPVANRTSYTFQLRKLIA
                     VTSYGLLRLQVALIYFEACVGKFKVPEWADGTAIYYWFSNPTFGLSPDVHSLLLPVLAN
                     RWCIVLLTWSVLFLEGGLFLGLTLEQKYRRYLLWAGVGFHFMIILIHGLPTFFMAMTAA
                     LVIFLRPFDQPFNTVPALNRLRSLIPQLPALKASRVSPASI"
     gene            complement(1353..1895)
                     /locus_tag="AWR27_RS15980"
                     /old_locus_tag="AWR27_15825"
     CDS             complement(1353..1895)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04034.1"
                     /locus_tag="AWR27_RS15980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AWR27_15825"
                     /product="SdpA family antimicrobial peptide system protein"
                     /protein_id="WP_157579243.1"
                     /transl_table=11
                     /translation="MKATRITFVGISLLWAGLAFFSLLTYVKDTPVRFSYEFQHNLRTL
                     FPQGWAFFTKSPRDENIQLYRWENNRLILVDGQRQATFANLMGFRRSSRAMSVEYAYLL
                     YNVPTTKWTRCETDPEAYIRSHKLTEVRVENNTPRPYLSGTYYLIQRGIVPWAWSSQTN
                     RITLPSSILKLTVICNR"
     misc_feature    2002..2015
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 19.58"
                     /tool="antismash"
     misc_feature    complement(2003..2016)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.37"
                     /tool="antismash"
     gene            complement(2123..2740)
                     /locus_tag="AWR27_RS15985"
                     /old_locus_tag="AWR27_15830"
     CDS             complement(2123..2740)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AWR27_RS15985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AWR27_15830"
                     /product="hypothetical protein"
                     /protein_id="WP_077132096.1"
                     /transl_table=11
                     /translation="MNKSRRDVLKRMSLAALAGFTPLYGFSDATKKRIVTGEDMYRGIF
                     FAEGAFAQLIPEIQSLKMAYAPASLAGSQVETVRRQIIDHLRQSDTAFFTKFKAALMSH
                     DVQCVERQLRSASERTAKTLDILYNSSTATNNGYRLRKKPMAPGQGEVLLVANAVACVN
                     VIYILCSAAIFDQEEVVGTQQASPLLLEQMALSICAVAPTLA"
     gene            complement(2761..3474)
                     /locus_tag="AWR27_RS15990"
                     /old_locus_tag="AWR27_15835"
     CDS             complement(2761..3474)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AWR27_RS15990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AWR27_15835"
                     /product="hypothetical protein"
                     /protein_id="WP_077132097.1"
                     /transl_table=11
                     /translation="MITSIRKSFLNAYTALPLLICFVLASFHSFALNNKTTRATFLSGQ
                     ELFAGVFFLEGRYAQMLPETQSFQTAYLNQQQSSDQKAAVAQVRQAVLAQIESARPGYF
                     AHFKSAMKSGDHLRVSAALAEGQALVGQALDVLYELDKAELGRLQAKAQAEAARQGGKL
                     DAQAIEKLVADMQKGKAVDANSGTCLVTILAVAIILWVVVVVAAEEEITLNTNGHSLMH
                     EQLVASICNVASTIA"
     gene            complement(3521..4129)
                     /locus_tag="AWR27_RS15995"
                     /old_locus_tag="AWR27_15840"
     CDS             complement(3521..4129)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AWR27_RS15995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AWR27_15840"
                     /product="hypothetical protein"
                     /protein_id="WP_077132098.1"
                     /transl_table=11
                     /translation="MTTFIRQYLLNAYTALPLLVCLLVASWAAQARPLGVTHRYSGEEM
                     FRGLFFLEGRYAEAIPELKSMSLSYTAKLAKAADKKAKIHATRQRLIQTLLAEDKFVFD
                     KFRAAVESGNPLIIKSKLEQTQQKLEELVAFQSKSRKSVETNQGNCLIILIVTSESAAS
                     LSMQVIAMVLSPEEITQTNSRLLTEQLVASMCRLSANPS"
     gene            complement(4234..4959)
                     /locus_tag="AWR27_RS16000"
                     /old_locus_tag="AWR27_15845"
     CDS             complement(4234..4959)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AWR27_RS16000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AWR27_15845"
                     /product="hypothetical protein"
                     /protein_id="WP_077132099.1"
                     /transl_table=11
                     /translation="MITSIRKSFLNAYTALPLLICFVLASFHSFALNNKATRATFLSGQ
                     ELFAGVFFLEGRYAQMLPETQSFQTAYLNQQQSSDQKAAVAQVRQAVLAQIESARPGYF
                     AHFKSAMKSGDHLRVSAALAEGQALVGQALDVLYELDKAELGRLQAKAQAEAARQGGKL
                     DAQAIEKLVADMQKGKAVDANSGTCAVIAVVVLVVAVAAVWVAIAVSENEVLSDNRNTK
                     SLMHEQLVASICEVAPSIA"
     gene            complement(5082..5810)
                     /locus_tag="AWR27_RS16005"
                     /old_locus_tag="AWR27_15850"
     CDS             complement(5082..5810)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AWR27_RS16005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AWR27_15850"
                     /product="hypothetical protein"
                     /protein_id="WP_077132100.1"
                     /transl_table=11
                     /translation="MITSIRKSFLNAYTALPLLICFVLASFHSFALNNKATRATFLSGQ
                     ELFAGVFFLEGRYAQMLPETQSFQTAYLNQQQSSDQKAAVAQVRQAVLAQIESARPGYF
                     AHFKSAMKSGDHLRVSAALAEGQALVGQALDVLYELDKAELGRLQAKAQAEASRQGGKL
                     DAQAIEKLVADMQKGKAVDTNSGTCAVIVVVVVAVAVAVVLVAVALVAEEVLSADNRNT
                     KSLIHEQLVASICNVAPTIA"
     misc_feature    complement(5840..5855)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.08"
                     /tool="antismash"
     gene            complement(5980..6708)
                     /locus_tag="AWR27_RS16010"
                     /old_locus_tag="AWR27_15855"
     CDS             complement(5980..6708)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AWR27_RS16010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AWR27_15855"
                     /product="hypothetical protein"
                     /protein_id="WP_077132101.1"
                     /transl_table=11
                     /translation="MTTFIRQYLLNAYTALPLLVCLLVASWAAQARPLGVSHRYSGEEM
                     FRGLFFLEGRYAEAIPELKSVSMTYSYKLAKVSSKDAIHKTRNQLVATIRAEQPMFFDN
                     FQKAMESGNHLRVESTLRAARKVVEATAERLYKLDMQQIEKLQRQTLKLADEGKLTRDV
                     VEQMAKNLQKEQYQTRQGNGTCIVLPLPPVIDLACSLIVILYCPVVVYVVAVEQTVQAD
                     SRLLTEQLVASICQISANPS"
     gene            complement(6754..9144)
                     /locus_tag="AWR27_RS16015"
                     /old_locus_tag="AWR27_15860"
     CDS             complement(6754..9144)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1082:
                     TonB-dependent siderophore receptor family"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF026255.4"
                     /locus_tag="AWR27_RS16015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AWR27_15860"
                     /product="outer membrane beta-barrel family protein"
                     /protein_id="WP_077132102.1"
                     /transl_table=11
                     /translation="MKAYLVIWLLIGTLPGFGAPTTPFRCPADTFAVARLESKWIVQGT
                     VTDSTSGQSVPYATLQLFDLRQQRPLNGLTADANGKFTVEILPGTAYRIDVSSVGFAPK
                     SLPVPPPDAHQRTVLAIMLKANATTIREVSVRASKPIVEEQLDRLVYHADRDNTAQGGL
                     ATDVLRKVPLVTVLPDGGLSVRGTANVKLLVNGRSSVLSNNPAELLRQIPAESIKTVEV
                     ITSPSAKYDAEGATLINIVTKKNLAQGVNATLNGGIGSTGSNAASTLSMNYKKLSISSS
                     LTGNWFYNPFAAEADIYQIRGTDRQLVTRQQASGTIGIQVVNANANAEYRLSGKSRLLV
                     GLNHRVRRVRTDRDAQFSSGTGETTLPAGHYQSLIDSKTNDWTVEYNHTFGRVQQELTL
                     SWTGGITRNQTLATPAPPTQADIRSQNDEQVFQADYQHPIRRNWLVETGLRLTMRHIGN
                     SLSDSLSTQRLTTLDYRQQISAGYVSSQWDLKKKWSLRTGLRLEHTHNDIRQTTDQREQ
                     QYLNLFPSVLFQKRLKNARSLKFSYGMRIQRPPAQLLNPAVATTDPVSRYTGSPLLKPE
                     QMQTAELSYSTYIKANSLILSAFVRKTSYPISPYNALIGSTLVTQYVNVDRQTDIGLNL
                     YMSVKLWQRWQTIGTANLYYASVVSQPEQGNLTNRGVNYTLGTLSTYELAKTWAVQLYG
                     GYNSARLRLQGRDQAFTYYQLSVRKNLPQQKGSIALGIDNPLQRRAAWVSYNETDTFAF
                     RSIAYQYNRGIRLTVIYRIGKSGPRQESAKSRERRQSDLKEEQ"
     gene            complement(9201..9947)
                     /locus_tag="AWR27_RS16020"
                     /old_locus_tag="AWR27_15865"
     CDS             complement(9201..9947)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AWR27_RS16020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AWR27_15865"
                     /product="hypothetical protein"
                     /protein_id="WP_077132103.1"
                     /transl_table=11
                     /translation="MKTLFLSALLVAASPALTMAQGQSTPVRFAAVQTPTLTAQTVLTK
                     HIEALGGTEKLNALKSIIVKQTTSAQGQEVPQTLYILPGKGVRSEMNAMGFEIVVAARA
                     DSGWQVNPAQYGNAQPVALSARQARSVCAQADLFGPLVTAHEKGFAITYDGDEKIEGDL
                     SYKLTVTTPTGNQYVAFVSQQNHMLVKLITKSSEVFYADYRNIDGYWFPHTVEVISSGN
                     KANIIDRSFEVNKPISDNLFDMPAAK"
     gene            complement(10001..11095)
                     /locus_tag="AWR27_RS16025"
                     /old_locus_tag="AWR27_15870"
     CDS             complement(10001..11095)
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AWR27_RS16025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AWR27_15870"
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_157579244.1"
                     /sec_met_domain="LANC_like (E-value: 0.00039, bitscore:
                     17.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLPISPARVNYLQQAQQYVDELMHTAHEALRQMDDANRWLCRLW
                     TGTTDRLWLEQVLSRHEPVSDTALLPTLLGCLYLYRHGPPDELLWLLLEQVNARLYKQT
                     AEQFERGHVGLLTGGSTSLNYLIRAGLYAPNAQKYASQLTTQVVESGTGSNHPITDLSV
                     GYGQTGLILTLTEAATNATMAQRIVGSVREVERLIEQYVRYLANHQIPIDSQDDNWSIF
                     PITVAETEWTLPERFSWETGDVGQLLLLYRAHRLLNQPDLARWADRLSGYVLQRRATNK
                     VRVERIGLTDGMAGLSLLYRQLYRITGRADFLHEGEYWLEQLIDVVKAGRYPPDGSLQT
                     GMLGVDATLRHWLGEDLGLDLLFV"
     gene            11504..12550
                     /locus_tag="AWR27_RS16030"
                     /old_locus_tag="AWR27_15875"
     CDS             11504..12550
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018305.4"
                     /locus_tag="AWR27_RS16030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AWR27_15875"
                     /product="sensor histidine kinase"
                     /protein_id="WP_077132105.1"
                     /transl_table=11
                     /translation="MNRKPILIHASVWIVYLLLNNLLLFNWNLQRLFIVQMPFTYGLVA
                     ILFYTNVYAIINPCVQRKQYARLLLYTVLLVGSYVAIRLWLFDIVLPGLGIRTIYSETF
                     IVYNRFIPDSLWLALQYILLSYGYWFAMYSIRLEREKRLNEQRIAALEVEKARSELAFL
                     RAQLNPHFLYNTLNFFFSDALMVSPRLADSIMALSQMLRSVSEVGYQSLVAVGQELNYI
                     RCYLKIQQYRFGDQLHVQFQVTGQEYEQHLTIPPLILISLVENIFKYGDVFDAATPARI
                     TVDLTDDQIRFSTMNSKKDVPNYMQGGLGLANIDKQLNLTFGNRYSFEKQEINNIFSTS
                     LHISVTNL"
     gene            12572..13297
                     /locus_tag="AWR27_RS16035"
                     /old_locus_tag="AWR27_15880"
     CDS             12572..13297
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020607439.1"
                     /locus_tag="AWR27_RS16035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AWR27_15880"
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_077132106.1"
                     /transl_table=11
                     /translation="MINCFILDDEQAAINVLTKYITDTPYLHLAGSTTSAPQAIEMLKQ
                     TPVDLLFLDIQMPLLTGLQFIDLYGSNLQVIFTTAYSEFALNGFERNALDYLLKPIPFD
                     RFLKATEKALNYFNRQAITPNAPVADDFILVKTEHKGKLRKVNFDEIVYIEGLKNYVSI
                     FTNKQEQIVTYSGIGELEERLPPRQFARVHRSYIVAIRMINAIDGNELFMKDAPRIPTS
                     GRYKDELLTLLQKSILQNK"
     gene            13309..13680
                     /locus_tag="AWR27_RS16040"
                     /old_locus_tag="AWR27_15885"
     CDS             13309..13680
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="AWR27_RS16040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AWR27_15885"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_077132107.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.4e-19, bitscore:
                     67.1, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLLPADFFVLRRPLLALDEFLAVERQLAEGQSLADVLLGVYAD
                     ELRREALFYASPTVHAALVAWQTGGPLPNEKLLLTLYKYFVRMTTRSTPFGLFAGIGLG
                     QWGQCRICAWGPPFPATFD"
     gene            13632..15098
                     /locus_tag="AWR27_RS16045"
                     /old_locus_tag="AWR27_15890"
     CDS             13632..15098
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="AWR27_RS16045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AWR27_15890"
                     /product="lantibiotic dehydratase family protein"
                     /protein_id="WP_198045016.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.2e-93, bitscore:
                     312.5, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDLRVGATVSRHLRLDAGLVSQLAHTISQLPYIRRQLSYTTNDS
                     VWVIGDVLHYIGFNEENGQRSYYQNEVKTDACLLQLLENARQGLPYSTLSEQLKQAGVD
                     TDTVMSYLDALIDSQLLVSDLSINLTGPDPLVRLNERLATRSGTGPLVERLTHLQALLP
                     CCGPMSNQQIETLLHELAVSAQPPYVQCDTFLPDDTLVLSTVVQAELGHTLSDLAERSR
                     PSVNSSLDTFKRRFFARYENQAVPLLEALDPDAGIGYDLHQEMPTPWLDSLPWHSEASS
                     APAETVVSEHLLKLYVSAIQQQEMVIQLTKQDLDTILPVQPNLPLPGSGYAIGQLMGQP
                     NAPDSLFLLKGMGGPSAANLLGRFAHLSPELEARLKQCLQDEQAMYPDALLAELVHLPG
                     ARTGNVLRRPILRPHELPILTRSMVPESHQLSLRELRIAVPDGQRVVLLSHRLNQQVIP
                     RLSTAHNVQAGGWLIIGFCMTCNSRKPVYA"
     gene            15041..16342
                     /locus_tag="AWR27_RS16050"
                     /old_locus_tag="AWR27_15895"
     CDS             15041..16342
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="AWR27_RS16050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AWR27_15895"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_077132108.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6.7e-27, bitscore:
                     92.0, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.1e-41, bitscore:
                     139.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAHYRFLYDLQQQEASLRIVWDWGPLKTMPFLPRLTYRNVVLSRA
                     QWHLRRQDVETIPSTAWVNWQTAHRLPRYVLLAEGDNELVIDTEITVGLQLLTQALQRN
                     GQVTLLEWPEAVTRPLAHSDQEQYWSHELLIPLRNTTPQPTLAKLLATPVSASVHDRLF
                     APGNRWLYLKLYVGPAAADALLAEHLPALLASLQAQNALQSWFFIRYADPEKHLRLRFL
                     ASSGQTDTVLQVISSWANARMAADSRIYRVQFDTYQRELERFGPKTIEICETWFGHDSQ
                     AIVQLLGWLIHQPDWQRLRVGCLFVHQLLTSWGYTIAEQLERIEVWRDMFLREFKADKL
                     FQHEVNAQFRVYRPFLDKPTPSEPMLQQWLAVYGEQAAAFQQELKRADPASPNRLLPHI
                     THLFLNRLFADSQRKHEQIIYCFLYKLLKQWQRT"
     gene            16496..17134
                     /locus_tag="AWR27_RS16055"
                     /old_locus_tag="AWR27_15900"
     CDS             16496..17134
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009281176.1"
                     /locus_tag="AWR27_RS16055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AWR27_15900"
                     /product="MCP four helix bundle domain-containing protein"
                     /protein_id="WP_077132109.1"
                     /transl_table=11
                     /translation="MNQPTQPRSRLRATLLLIGILGLILTSIFLSRSSVGQIEKSVASI
                     YKDRLAPTAILVHLTSNLYGKRLVLENYLLSAERPDPTLLQGQMDRSDRHTDSLLTEFE
                     QTRLTQREAEELRAFRQYITEYNQLEKQVLQQATTNRTQAQKMLFTGSGNTAFGQAATK
                     LDELSALQLTVGEELLSESRSNVDHIYVFSALQIGLTLLIGIIVFRRGI"
     gene            complement(17137..20139)
                     /locus_tag="AWR27_RS16060"
                     /old_locus_tag="AWR27_15905"
     CDS             complement(17137..20139)
                     /EC_number="3.6.4.-"
                     /GO_function="GO:0004386 - helicase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012930623.1"
                     /locus_tag="AWR27_RS16060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AWR27_15905"
                     /product="DEAD/DEAH box helicase"
                     /protein_id="WP_077132110.1"
                     /transl_table=11
                     /translation="MKVHPTQPFQIVYSLLDHEFLGYLIEAFVVQRNSRGELTLQNQTL
                     STQNVGEFARGLDERDFELVRLIDSIQQDTIVKKFNTRRLPAVDFFLKIYDAQKGDKLV
                     QEAIAGYLENLKAQIMTLMPGKPFYVMGNDGNPAWQPITWMPEPARVHFHFVRNADSTH
                     YFPIIRYPTGSTGETERVEFQFKDALMVCDEPACLLVNNRLYQFSRNVDGKKLRPFFTK
                     NHIVIPRNLEPQYYERFVTQLIASYDVYAKGFEIRSEVIEPQPVLTVSELVTSSRSMST
                     LAVGREGNSAEVVETDESTRKIAFDLSFRYGDSMFRYDNFGPSANVSLEQKGDEYIFHK
                     IRRDQRLERQKLTTLREAGLDLRHGRMALTKAEAFAWLADNSAKIQEAGFVLQQHAQDT
                     KRYFLGYSSINVSIEEGRDWFDIYANVQFGEFVIPFLKLRTLILNKKREFTLPNGEVAV
                     IPETWFTRYSELFGFLERSGGIDADGADRLVLRKHHLALVQELERDNLATTVMSRKLER
                     LRDFSEIESYPIPVHFNGTLRPYQQAGYDWMNFLRQYRFGGCLADDMGLGKTVMTLAML
                     EGQKEAANTEPDAARPNLLVMPTSLLYNWELEARKFTPDLRVMVYTGTYREKNTAQFDD
                     YDLILTSYGIVRIDIDLLSDYRFNYVILDESQAIKNPSSHITKAVMQLNTAHRLILTGT
                     PLENSTMDLWSQMTFINPGLLGSQSFFRNEFQIPIEKRHDEAKTNRLYSLIKPFMLRRN
                     KAQVATDLPEKVESVLYCDMSPDQAEQYEEAKSYYRNLILERIEEDGMAKSQMIVLQGL
                     TKLRQIANHPRMVDAGYEGDSGKLDDVLLRLESAMTEHHKVLVFSQFIKHLSVVEQHLN
                     ERGIKYAYLDGSTTDRQSQVELFQTDDSVKLFLISLKAGGLGHNLTAADYVFILDPWWN
                     PAIEAQAVDRAHRIGQQRTVFTYKFIAKNTVEEKILSLQRAKQQLAGSLITTEENFMKS
                     LTKEDILVLLE"
     misc_feature    20102..20116
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 20.2"
                     /tool="antismash"
     gene            20464..20709
                     /locus_tag="AWR27_RS16065"
                     /old_locus_tag="AWR27_15910"
     CDS             20464..20709
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AWR27_RS16065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AWR27_15910"
                     /product="hypothetical protein"
                     /protein_id="WP_077132111.1"
                     /transl_table=11
                     /translation="MPSSEPDKTRPIQRNDSFLRLRKDKLMVYVDPHFGFIRQVYKGVF
                     YIKKCAYCKRTFEAKRRHAAFCSPTCQQAHRRGRNR"
     misc_feature    20726..20742
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 21.04"
                     /tool="antismash"
     gene            20805..21683
                     /locus_tag="AWR27_RS16070"
                     /old_locus_tag="AWR27_15915"
     CDS             20805..21683
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016013.4"
                     /locus_tag="AWR27_RS16070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AWR27_15915"
                     /product="DUF389 domain-containing protein"
                     /protein_id="WP_198045017.1"
                     /transl_table=11
                     /translation="MNDLLQIDEVVGLALYPDNSYKPTPGDVLSVQLLNRGSDKVLRAI
                     ANRCGDAPYLVSTSLTESIIETGQSGKLENDLDEAIWEEIETGMRHQGRVTFNFVVLMA
                     LGGIMATIGIVAEPTRQVMPFVAAAIIAPGFEPVAALGLALVLRRWIVLWRAFRSSLVG
                     YSTLIAASALTFLFLQAIGEATVSDFAGSEEVKHLAHPTTADTLLSVCGTISGAIIMSS
                     FRKSVIAGALIAMVIINAAAVVGIGLASGRYDLAGQGLQRFGVDVAMIVGACMLVFWAK
                     QQFFHNRKPIA"
     gene            complement(21823..24315)
                     /locus_tag="AWR27_RS16075"
                     /old_locus_tag="AWR27_15920"
     CDS             complement(21823..24315)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0009265 - 2'-deoxyribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020600208.1"
                     /locus_tag="AWR27_RS16075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AWR27_15920"
                     /product="ribonucleoside-diphosphate reductase subunit
                     alpha"
                     /protein_id="WP_077132113.1"
                     /transl_table=11
                     /translation="MYVIKRDGRRESVKFDKITARIEKLCYGLDPAYVQPVEVAMKVVN
                     GLYDGVKTTELDNLAAETAASLTTRHPDYAILAARIAISNLHKETNKSFSGTIKQLYHY
                     EDPKTGENASLISKEVYDVVRTNAALLDSTIIYDRDYGYDYFGYKTLEKSYLLKTNGRI
                     AERPQHMLMRVAVGIHLDNIDAAVETYNLLSEKWFTHATPTLFNAGTPKPQMSSCFLLT
                     MKDDSIDGIYDTLKQTAKISQSAGGIGLSIHNIRATGTYIKGTNGTSNGIIPMLRVFND
                     TARYVDQGGGKRKGSFAVYLEPWHADIFDFLDLKKNSGKEESRARDLFYALWTPDLFMK
                     RVEDNDVWSLFCPHECPGLADCYGEEFEALYERYEREGRARKTIKAQELWFKVLESQTE
                     TGTPYMLFKDSANRKSNQKNLGTIKSSNLCTEIIEYTAPDEVAVCNLASIALPKFIKRD
                     PDGILRFDHQKLLEITKVATRNLNRIIDLNYYPVEEARRSNMRHRPIGLGIQGLADAFI
                     LLRMPFESDEARRLNEDIFETIYFGAMTASMELAKEHGPYETWKGSPISQGIFQFDMWE
                     RDGKPVTPKSGRWDWESLRKDVVEHGVRNSLLLAPMPTASTSQILGNNECFEPYTSNIY
                     TRRVLSGEFVVVNKHLLKDLVKLGLWNDTMKNNLIRANGSVQQVPGIPQNIRDLYKTVW
                     EIKQKHIIDMAADRGAYICQSQSLNIHIQDSNFGKLTSMHFYAWKAGLKTGMYYLRTKA
                     AADAVKFTVEPQAEPQLEPVLAETIAVEKPLDYVQYAKDHATNQQPTPVPMVTELEQQY
                     AAMTCSLDDPEGCEMCGS"
     misc_feature    24454..24471
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.24"
                     /tool="antismash"
     misc_feature    complement(24456..24471)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 21.71"
                     /tool="antismash"
     misc_feature    complement(24511..24525)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 20.5"
                     /tool="antismash"
     misc_feature    24522..24542
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 23.59"
                     /tool="antismash"
     gene            24788..25030
                     /locus_tag="AWR27_RS16080"
                     /old_locus_tag="AWR27_15925"
     CDS             24788..25030
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009284398.1"
                     /locus_tag="AWR27_RS16080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AWR27_15925"
                     /product="type B 50S ribosomal protein L31"
                     /protein_id="WP_077134029.1"
                     /transl_table=11
                     /translation="MKKGIHPDYRDVVFHDLSSDYKFLTRSTVQTRDTVEFEGKTYPLV
                     KIEVSSQSHPFYTGKNVLLDTAGRVDKFRKRYGTK"
     gene            complement(25119..25262)
                     /locus_tag="AWR27_RS25345"
     CDS             complement(25119..25262)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AWR27_RS25345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157579245.1"
                     /transl_table=11
                     /translation="MKRSTKVILIVVLLALVGYLLTVGHIHYQLSSAKPTQRTVERAGA
                     RQ"
     gene            complement(25355..25780)
                     /locus_tag="AWR27_RS16085"
                     /old_locus_tag="AWR27_15930"
     CDS             complement(25355..25780)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AWR27_RS16085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AWR27_15930"
                     /product="hypothetical protein"
                     /protein_id="WP_198045018.1"
                     /transl_table=11
                     /translation="MKKTHAPLIALLLTVSTFAKAEKKEGTPAAQTVTLKTHLLPGFLY
                     FVKGDITLTSDSLRFMSATECFDWKLLGKIYPCHNDLFRAVQVPLSSIAKVSRRNTLLI
                     FPNKFVVRLKDGRKYKFFSYKRGRILRALKQNPQYGA"
     misc_feature    26212..26225
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.57"
                     /tool="antismash"
ORIGIN
        1 gcaacttgcg gtggtgccaa attgatatcg ataacgggcg aaaacatcgt acaaaccgtc
       61 gcgtaggggg cgcggcaccc accgcagcca ccaaatccaa cgccacggac cagctaatcg
      121 ccgaccgatt cgcagtatgg cttccgaacg gatgtacacc acgccttcgt ctaccagcac
      181 gatactgtcg ggtggggtgt tgccagccat ccggcgcaat tgctcgccca ttgccgactg
      241 agccgacacg aaggagaagt agcccagtgg gtcgcgctca agtacgaact gcacgtaagc
      301 gttgcaaaag ccgcacaccc cgtcgaaaac aatgattgct ttcatggttt cagtacattg
      361 accgggcgcg tgacgcgccc ggccatgaac gttatgttag atggatgcgg gcgaaacgcg
      421 cgatgctttc agcgcaggta actgcggaat caggctgcgg agccggttca gtgcgggcac
      481 ggtgttgaac ggttgatcga acgggcgcag gaagatgacc agcgcggctg tcatggccat
      541 gaaaaacgtg ggcaatccgt gaatgaggat aatcatgaaa tggaaaccca cgcctgccca
      601 gagcagatac cgccggtatt tttgttcgag agttagcccc agaaacagcc ccccttccag
      661 aaacagcaca ctccacgtga gcaacacaat acaccagcgg ttggccaata ccggcagcag
      721 caggctatgc acgtcgggcg aaagaccgaa ggttgggttc gaaaaccagt agtaaattgc
      781 cgtaccatcg gcccactccg gcaccttgaa cttgccaacg caggcttcaa aataaatcag
      841 agctacctga agtcgcaaca gcccatacga agtaacagca atgagtttgc gaagctgaaa
      901 cgtatagctc gttctgttgg caaccggagc catcgaccag tgccaggtgc gcgggtcggt
      961 cagggccagc ggcagcagca gaccgctcag cacgagcgta acctgatcgc ccccatcgac
     1021 cagcactgcc gtcgacatga agctgaaacc cacataaaca tggagcagag ccgtaaatcg
     1081 gggatagatg ccaatcaata ccagaaaaag aatagtcata cacacccaac gagccgtttc
     1141 cagatcgccc atccagcaaa acagactata ctcggccagc cccatacaag acgggcagtc
     1201 ggtttgaccg gcaatgggcc gaaacagcgt acccatgtcg ttgaaaagca gcgtacagaa
     1261 tgtgcctaaa gccagcaatg agcgcacaaa gccatacacg ttggtccagg gattacgcgc
     1321 cagcagcgcg ttgaggtagc ggtcgaaagc agttagcggt tgcatataac ggttagtttt
     1381 aagatggatg acgggagcgt gatgcggttg gtctgcgacg accaggccca ggggacaata
     1441 ccgcgctgaa tcaggtaata cgtgccgctg agatacggtc ggggcgtatt gttttcaact
     1501 ctcacctcgg taagtttatg cgaacgtatg taggcttccg gatcggtttc gcagcgggtc
     1561 catttagtag tgggtacgtt atagagcaga taggcatact cgacgctcat tgcccgcgac
     1621 gaacgccgaa agcccatcag gttggcaaac gtggcctgcc gttgaccatc taccagtatc
     1681 aggcgattgt tttcccagcg ataaagctga atattttcgt cgcgagggct tttggtgaag
     1741 aaggcccagc cctgcggaaa cagcgttcgg aggttgtgtt gaaactcgta gctaaaccgg
     1801 acgggtgtgt ctttcacgta agtgaggaga gagaaaaaag ccagcccagc ccatagcaag
     1861 ctgatgccaa cgaaggtaat tcgggtcgct ttcatagcgg tatcgggttt atgtgttgcg
     1921 attgttcgtc tcaggcaaag cagccgggtg gtgcgggcct gtttgatgat cgaaaattgc
     1981 gaaacccgcg ccacccgctg aattttatta tacaattcgc ccgattcgcc gtatgaaatc
     2041 tcatattcgc aggatgcaca acagccgacc ctatttttta gggtcggctg ttaaacaata
     2101 gtcgctacct caacgcaatt ggctacgcca gcgtgggtgc aacggcacag atagaaaggg
     2161 ccatctgctc cagcagcagg ggcgatgcct gctgcgtacc taccacttct tcctgatcaa
     2221 aaatggccgc cgagcagaga atgtaaatca cattcacaca ggcgacggca ttggctacca
     2281 gcagtacctc gccctgaccc ggtgccatcg gctttttccg aagccgatac ccgttgttag
     2341 tagcagtcga cgaattatac agtatgtcga gggttttggc ggtgcgctcc gaagccgacc
     2401 gaagctgccg ctccacacac tgtacatcgt ggctcatcag cgcagctttg aatttggtaa
     2461 agaacgctgt atcgctctgc cgcaggtggt caatgatttg ccgacgcacg gtttcgacct
     2521 ggctacccgc cagcgacgca ggtgcataag ccattttgag cgattgaatt tcgggaatca
     2581 gttgggcaaa tgcgccctca gcgaagaaaa tgccccggta catatcttcg cccgtaacta
     2641 tgcgtttttt ggttgcatcg ctgaatccat acaggggggt aaaccctgcc agtgcggcta
     2701 aactcattcg tttcagcacg tcgcgtcgag acttgttcat gatatgtaag tcgttagagg
     2761 ttaagcgatt gttgacgcta cgttgcagat agatgccacc agttgctcat gcatcagcga
     2821 gtggccgttt gtgttcaacg tgatctcttc ttcagccgcc accacaacca caacccatag
     2881 aatgattgca acggccagaa tcgtaactaa gcacgtaccg ctgttggcat caacggcctt
     2941 gcccttctgc atgtcggcca ccagcttctc gatagcctga gcgtctaact tgcccccctg
     3001 ccgggccgct tccgcctgcg ctttggcctg caaacgaccc aactcggcct tgtccaactc
     3061 atagagcacg tccagtgcct gacccaccag agcctgcccc tcggccaaag ccgcactcac
     3121 ccgcagatgg tcgccactct tcatggccga cttgaagtgg gcaaagtagc ccggacgagc
     3181 cgactcgatc tgggccagca ccgcctgccg cacctgggcc actgccgctt tctggtcgct
     3241 gctctgctgc tggttgaggt aggctgtctg gaacgattgg gtttcgggca gcatctgggc
     3301 atagcggccc tctaagaaaa acaccccggc aaacagctcc tgaccgctca gaaaggtggc
     3361 gcgggtggtt ttattgttga gggcgaagct gtgaaaggag gccagcacga agcagatcag
     3421 cagaggcagg gccgtgtagg cattcagaaa cgatttacga atcgacgtaa tcatggttga
     3481 taactggttt aggaggtttt agaaaaggaa atgaaaacac ctatgaagga ttggccgaca
     3541 gacggcacat tgacgccaca agttgctcgg tcaataggcg tgagttagtt tgtgttatct
     3601 cttcggggga gagtaccata gcaataacct gcatagataa agaagctgca ctctcagaag
     3661 tgactataag aataatcagg caattaccct ggttagtctc tacggacttt ctggactttg
     3721 actgaaaggc taccaactct tcaagttttt gttgagtctg ttccagtttc gatttaataa
     3781 tcaatggatt gccactttct acagcagccc gaaatttgtc aaacacaaac ttgtcttccg
     3841 ccaacaatgt ctgtataagc cgttggcgag ttgcgtgtat cttcgctttt ttatcagcgg
     3901 ccttagccag ttttgctgta tagctcagac tcatactttt gagttcggga atggcttcgg
     3961 catagcggcc ctctaagaaa aacaggcccc gaaacatctc ctcgcccgaa taccggtgcg
     4021 taaccccgag tgggcgggcc tgagcagccc aactggcaac caatagacac actaacaacg
     4081 gaagagccgt gtaggcattc agcagatact ggcgaataaa cgtagtcatg agtgataagc
     4141 agtttaggag tagaatcaga cttatttata caaagaggtt cggtattagc acatctgttt
     4201 gcacacatac cgaacctcta ttgaatcgat tacttaagca atgctcggag ccacttcgca
     4261 aatcgaagcc actaattgct cgtgcatcag cgatttggtg ttgcgattgt cgctgagtac
     4321 ttcattctcc gatacggcaa tggccaccca aacagccgcc acggccacta ccagcacgac
     4381 aactgcaatc accgcacagg taccgctgtt ggcatcaacg gccttgccct tctgcatgtc
     4441 ggccaccagc ttctcgatag cctgagcgtc taacttgccc ccctgccggg ccgcttccgc
     4501 ctgcgctttg gcctgcaaac gacccaactc ggccttgtcc aactcataga gcacgtccag
     4561 tgcctgaccc accagagcct gcccctcggc caaagccgca ctcacccgca gatggtcgcc
     4621 actcttcatg gccgacttga agtgggcaaa gtagcccgga cgagccgact cgatctgggc
     4681 cagcaccgcc tgccgcacct gggccactgc cgctttctgg tcgctgctct gctgctggtt
     4741 gaggtaggct gtctggaacg attgggtttc gggcagcatc tgggcatagc ggccctctaa
     4801 gaaaaacacc ccggcaaaca gctcctgacc gctcagaaag gtggcgcggg tagccttgtt
     4861 gttgagggcg aagctgtgaa aggaggccag cacgaagcag atcagcaggg gcagagccgt
     4921 gtaggcattc aagaacgatt tgcgaattga ggtaatcatg gttgataact tggtttagaa
     4981 ggttttagaa aaagaagttg aagaaaaaga ctcagaaaaa ggggcggtat tcaggcaccg
     5041 gtctgctcga acaccagccc atacgtgtct atgaaaactg cttatgcgat agtcggggct
     5101 acattgcaga tagatgctac taactgctca tgtatcagcg acttggtgtt gcgattgtcg
     5161 gcagacaaca cttcttcagc taccaatgca acggctacaa gtacaacagc cacagctaca
     5221 gccactacga caactacaat caccgcacac gtaccgctgt tggtatcaac ggccttgccc
     5281 ttctgcatgt cggccaccag cttctcgata gcctgggcat ctaacttgcc cccctgccgg
     5341 gacgcttccg cctgcgcttt ggcctgcaaa cgacccaact cggccttgtc caactcatag
     5401 agcacgtcca gtgcctgacc caccagagcc tgcccctcgg ccaaagccgc actcacccgc
     5461 agatggtcgc cactcttcat ggccgacttg aagtgggcaa agtagcccgg acgagccgac
     5521 tcgatctggg ccagcaccgc ctgccgcacc tgggccactg ccgctttctg gtcgctgctc
     5581 tgctgctggt tgaggtaggc tgtctggaac gattgggttt cgggcagcat ctgggcatag
     5641 cggccctcta agaaaaacac cccggcaaac agctcctgac cgctcagaaa agtggcgcgg
     5701 gtagccttgt tgttgagggc gaagctgtga aaggaggcca gcacgaagca gatcagcaga
     5761 ggcagagccg tgtaggcatt caagaacgat ttgcgaattg aggtaatcat ggttgataac
     5821 ttggttttaa gggtttgaca tgaaagaatt gtgaaaaaat ggacacgaac tatcggggtg
     5881 atggctcaga ccggtaagcc aacacacagc gactatctta gaaaattaag atacagagta
     5941 agaaacggtc ggtggccgaa gcaccccgaa accgtataat caggacggat tggccgaaat
     6001 ctggcagata gaagctacca actgctcggt taacaatcgg gaatcggcct gaacagtttg
     6061 ctccacagca acaacataaa ctacaaccgg gcagtataga attacaatca gcgaacaggc
     6121 taaatcaata accggaggca gcggtaaaac aatgcaggtg ccattaccct gacgagtctg
     6181 atattgttct ttttgcaggt tcttagccat ttgttcgact acatcacggg tcagtttgcc
     6241 ctcgtcggcc aatttcagcg tttgccgctg aagtttttcg atttgttgca tatccagttt
     6301 gtagagccgt tcggcggtgg cttcaacaac cttgcgtgct gcccgtaaag tcgattctac
     6361 ccgcaggtga ttgccgcttt ccatcgcttt ttgaaaattg tcaaaaaaca tcggctgctc
     6421 ggcccggatg gttgccacga gctgatttcg ggttttgtga atggcatctt tgctactcac
     6481 cttcgcaagc ttatacgagt aggtcatact cacacttttg agttcgggaa tggcttcggc
     6541 atagcggccc tccaagaaaa acaggccccg aaacatttcc tcgcccgaat accggtgcga
     6601 aaccccgagc ggacgagcct gagcagccca actggcaacc aatagacaca ctaacaacgg
     6661 aagagccgtg taggcattca gcagatactg gcgaataaac gtagtcatga gtgataagcg
     6721 gttaagggtt taggaatcag gaaattggta agctcattgt tcttctttga gatcgctctg
     6781 gcgacgttcg cggcttttgg ccgactcctg gcgcggaccc gatttgccaa tccggtaaat
     6841 caccgtcagg cgaatgcccc gattgtactg gtaggctatg ctgcgaaacg cgaaggtgtc
     6901 ggtttcgttg tagctcaccc acgctgcccg gcgttgcaac ggattgtcga tgccgagcgc
     6961 gatgctgcct ttttgctgtg gcaggttctt acgcacactc agttgatagt acgtgaacgc
     7021 ctggtcgcgg ccctgtaggc gcagacgggc cgagttatag cccccgtaaa gctgcacggc
     7081 ccatgttttc gccagttcgt aggtcgaaag tgtaccgagc gtgtagttaa cgcccctgtt
     7141 ggtcaggttg ccctgctcag gctggctcac caccgacgca tagtacagat tggctgtgcc
     7201 gatggtttgc cagcgttgcc agagtttcac cgacatgtag aggttgagac caatgtcggt
     7261 ctggcggtct acgttcacat actgcgtcac cagcgtactg ccaatcaacg cattatacgg
     7321 gctgatggga taactggtct tccgaacaaa cgcgctcaga ataagtgagt tggcttttat
     7381 ataggtgctg taactcagtt ctgcggtctg catctgctcg ggttttagca gcggactgcc
     7441 tgtgtagcgg ctcaccgggt cggtggtggc tacggcaggg ttcagcaact gcgcaggtgg
     7501 ccgctgaata cgcataccat acgaaaactt caggcttcgg gcatttttca gccgtttctg
     7561 gaagagcacg ctcgggaata agttaagata ctgttgctca cgctggtcgg tggtttggcg
     7621 gatgtcgttg tgggtatgct caagccgcag cccggttcgc agactccact tcttttttaa
     7681 atcccactgg ctcgacacat atccggcact tatctgctgg cggtaatcca gtgtggtcag
     7741 tcgttgagtg ctcagcgaat cgctcaggct gttgccgata tggcgcatcg tgagccgcaa
     7801 ccccgtctca accagccaat ttcggcgaat aggatgttga taatcggcct gaaacacctg
     7861 ctcgtcgttc tgcgaccgaa tgtcggcctg ggtaggcgga gcgggcgttg ccagtgtttg
     7921 atttcgggta atgccgcccg tccagctcag cgtcaattcc tgttgtaccc gtccaaacgt
     7981 gtggttgtac tcaaccgtcc agtcgttggt tttcgaatcg atcagcgact ggtaatgccc
     8041 ggctggcagc gttgtttcgc ccgtacccga actaaactgt gcgtcgcggt cggttcttac
     8101 gcgcctgacc cggtggttca atccaaccag taaccggctt ttgcccgaca ggcggtattc
     8161 agcattggcg ttagcattca cgacctgtat gccgatggtg ccgctggcct gttgccgggt
     8221 gaccaactgc cggtcggtgc cgcgtatctg gtatatgtcg gcctcagccg cgaagggatt
     8281 atagaaccag ttcccggtta gtgacgaact gatactcagc tttttgtaat tcatcgacag
     8341 cgtgctggcg gcattgctgc ccgtgctgcc gatgccaccg ttcagcgtgg cgttgacgcc
     8401 ctgtgcgaga tttttcttcg tcacaatgtt gatgagcgta gccccttcag cgtcatactt
     8461 tgccgatggc gaggtaatga cctcaacggt tttgatcgac tctgccggta tctgccgcag
     8521 cagttcggcg gggttatttg acagcaccga cgagcggcca ttcaccagca gtttcacgtt
     8581 ggccgtgccc cgtaccgata gcccaccatc gggcagcacc gttacgagcg gaaccttccg
     8641 cagcacgtcg gtagccaaac cgccctgagc cgtattgtca cggtcggcat ggtacaccag
     8701 ccggtcaagt tgctcttcta caatgggttt gctggctcgc accgacactt cccggatggt
     8761 ggtggcattg gctttgagca tgatggccag tacggtccgc tggtgggcgt cgggtggtgg
     8821 aacgggcagg cttttcggcg caaaccccac gctcgacacg tcgattcggt aagcagttcc
     8881 aggcagtatc tcgacagtaa acttaccgtt ggcgtcggca gtaaggccat ttaacggtcg
     8941 ttgttgccgg agatcgaaga gctgcaaagt agcgtaaggt acagattgcc ccgacgttga
     9001 gtcggttacg gtgccctgaa cgatccactt actctccagc cgggccacgg caaacgtatc
     9061 ggcagggcag cgaaacggtg ttgttggtgc gccaaaacct ggcagggtgc cgatcaggag
     9121 ccaaattacc aaatacgctt tcatggcggc tgggagtaaa gatggataca gcagtgaaaa
     9181 gtcttcgcct gacttattcg ctatttagcg gctggcatgt cgaacagatt gtcgctgatg
     9241 ggcttattga cctcgaagct gcggtcgatt atgttcgctt tgttgccgct gctaattacc
     9301 tcaacggtat ggggaaacca gtagccatct atgttccgat agtcggcata gaacacctcc
     9361 gaacttttgg taatcagctt aacgagcatg tgattctgct gcgacacgaa tgcgacgtat
     9421 tgattgcctg tcggcgttgt cacggtcagc ttatagctta aatcgccttc tattttttca
     9481 tcgccatcgt aagttatggc gaatcctttt tcatgggccg taacgagcgg accgaacaaa
     9541 tcggcctgtg cgcataccga acgggcctgc cgggccgata acgccacggg ctgagcattg
     9601 ccatactgag ccgggtttac ctgccagccg ctgtcggcgc gggccgcaac aacgatttcg
     9661 aagcccatcg cgttcatctc gctccgaaca cccttaccag gcagaatata tagcgtttgt
     9721 ggaacttcct gcccctgagc tgaggtggtt tgtttaacaa taatcgattt gagcgcgttg
     9781 agcttttcgg ttccgccgag agcctcaatg tgcttagtca gtacggtttg agccgtgagc
     9841 gtgggcgttt gcacagccgc aaaacgcacg ggagtgctct ggccctgggc catcgtcagg
     9901 gcaggcgaag cagccacaag cagggccgat agaaagagcg ttttcatagg aaaaagggtt
     9961 taggaatacg ttagtttttt tgagagcctg agaccgtaat tcacacaaac agcagatcaa
    10021 gccccaagtc ttcacccagc cagtggcgaa gtgtggcatc aacgcccagc atacccgtct
    10081 gcaacgatcc atcgggcggg taacgtccgg ctttcacgac gtcgataagt tgctcaagcc
    10141 agtattcgcc ttcgtgcaaa aaatcagcgc gtccggtaat tcggtacaac tgtcggtaca
    10201 gcaaactcaa cccggccata ccatcggtta gtccgatgcg ttcaacacgc actttgtttg
    10261 tagcccgccg ttgcagcaca tagcccgata gtctgtcagc ccagcgggcc agatcaggct
    10321 ggttcagcag ccggtgcgcc cggtaaagga gcagcaattg ccccacgtcg cccgtttccc
    10381 aggagaaccg ctccggtaat gtccactccg tttcggccac cgttataggg aaaatagacc
    10441 agttgtcatc ctgcgaatcg attggtatct gatggttagc caaataccgc acatactgct
    10501 cgatcaaccg ttccacttct ctaacgctgc ccactatacg ttgagccata gttgcgttgg
    10561 tagccgcttc tgtcaaagtc aaaatcaggc cggtttgtcc gtagccaaca gacaggtcgg
    10621 tgatcggatg gttgctcccg gtgccactct ccactacctg cgtagttaac tggctggcgt
    10681 atttttgtgc gttcggcgca tataatcctg cccgaatcag gtaatttagc gaggttgagc
    10741 cgcccgtcag caggcccaca tgccctcgct caaactgctc ggcggtctgt ttgtaaagcc
    10801 gggcgttaac ttgttcgagc aataaccaca gcaactcatc gggtgggcca tgccggtaga
    10861 gatacagaca ccccagcaac gttggtaaca gggccgtatc tgacaccggc tcatgccgac
    10921 ttagcacttg ctccagccag agccggtcag tggtcccggt ccacaatcgg caaagccagc
    10981 ggttggcatc atccatctgc cttaacgctt cgtgggccgt gtgcatcaac tcatccacgt
    11041 attgctgcgc ttgttgcagg taattgacac gggccggtga aatcgggaga ttcatactga
    11101 cgagcaaagc attgagcgaa cgataaacca aagcaagctg gccggtgcgg tttttgccaa
    11161 ttttttatac caaccgccta tttcccgata agaacacctg cattgtcggt acacctatca
    11221 gaatgtaagc gtagttggca gcgtttggga catacattta ccctgcccga cagactgctt
    11281 tggcgacagg ttagcaattt tttttacatt gagcagtagt tggccggagt tgcggtaagg
    11341 gttttcataa cttattttgg ttagagttta cgatttgttt gcgtttgatg tctgaaagtt
    11401 gcagtataga atccatccac cataaaatat tatacgacgc ccttttttca cgatacgaaa
    11461 ccgctttatg tcttcacttc gtcaattatc aggttggtta aaaatgaatc gaaaacctat
    11521 tctgattcat gcatcggtct ggattgtcta tctgcttctt aacaacttac tgctattcaa
    11581 ttggaatctt cagcggttgt ttattgtaca gatgcccttc acctacggcc ttgtggccat
    11641 attgttttat accaacgttt acgctatcat taatccctgt gttcaacgca aacaatatgc
    11701 tcggctgttg ctctatacag tgttgttagt cggcagctac gtagccattc ggctgtggtt
    11761 atttgacatc gtattgccgg ggctgggtat tcgtactatt tactcagaga catttattgt
    11821 ttacaatcgt tttattcccg attcgctttg gctggctttg cagtacattc tgctgagcta
    11881 cggctactgg tttgccatgt attcaattcg gctggagcgg gaaaaacggc tgaacgagca
    11941 gcgcatagcc gcactggaag tcgaaaaagc ccggtcggaa ctggctttct tgcgggcaca
    12001 actgaatccg cattttttat acaacacgct taattttttc ttttccgacg cgctcatggt
    12061 gtcgccccgg ctggccgatt ccattatggc tctgtcgcaa atgctacgca gtgtgtcgga
    12121 agtgggctat cagtcgctgg tagccgttgg gcaggagttg aactatatcc gatgctatct
    12181 gaaaattcag caataccgct tcggcgatca gctacacgta cagtttcagg tcacgggcca
    12241 ggaatacgaa cagcatctaa ccattccgcc cctgattcta atctcgctgg tcgagaatat
    12301 tttcaaatac ggcgatgtgt tcgacgcggc cacaccggcc cgtatcactg ttgacttaac
    12361 tgatgatcag attcgttttt caacgatgaa tagcaaaaaa gatgttccta attatatgca
    12421 gggaggactt ggacttgcaa atattgataa acaattaaat ttgacctttg gtaatcgata
    12481 tagttttgaa aaacaggaaa ttaataatat attttcaact tcattacaca tcagcgtgac
    12541 gaacttgtag gcactaattc atttatccga tatgattaat tgctttattc ttgacgacga
    12601 acaggccgct attaacgttc tgaccaaata tattaccgac acgccctatt tacaccttgc
    12661 tggcagcacc acctcggccc cacaggcaat tgaaatgctg aaacaaacgc cagtcgatct
    12721 tcttttttta gacatccaga tgcctttgct gacggggcta cagtttattg atctctatgg
    12781 tagtaattta caagttattt ttacaaccgc ctatagcgag tttgccctga acggtttcga
    12841 gcgaaatgcc ctcgattacc tgctgaaacc tattccgttc gaccggtttc tgaaagcaac
    12901 tgaaaaggct ctcaactatt tcaaccggca ggccataacg cccaacgcgc cagtagccga
    12961 cgacttcatc ctggtcaaaa cggaacacaa agggaagctt cggaaagtta atttcgatga
    13021 aattgtgtat atcgaaggct tgaagaacta cgtatcgatt ttcaccaata agcaggaaca
    13081 gattgtaacc tacagcggca ttggtgaact ggaagaacgg ctgccacccc gtcagtttgc
    13141 ccgcgtacat cgctcttata ttgtagccat ccgcatgatt aacgccatcg acggcaatga
    13201 gctgttcatg aaagatgcac cccgcattcc aacgtcgggc cgatacaaag acgaattgct
    13261 gacgctgctg caaaaatcta ttctccagaa taagtaatct gtcttcgcat ggctcaattg
    13321 ctgccagccg atttttttgt gttgcgccgg ccactgcttg cactcgatga gtttctggcc
    13381 gtagaacggc agttggccga ggggcaatcc ttagccgacg tgctattggg cgtgtatgcc
    13441 gatgaactgc gccgggaagc tcttttttat gcatcgccaa cagtacatgc cgcgctggta
    13501 gcctggcaaa cgggcggacc actgcccaat gaaaaactgc tgctgacact ctacaagtac
    13561 ttcgttagaa tgactacccg cagcacgcca ttcggcctgt ttgcgggtat cggtctgggg
    13621 caatgggggc aatgtcggat ctgcgcgtgg gggccaccgt ttcccgccac cttcgattag
    13681 atgcgggtct ggttagtcag ttagctcaca caatcagcca gttaccatat atccgacgtc
    13741 aattatccta caccaccaac gacagcgtgt gggttatagg cgatgtgctg cactacattg
    13801 gcttcaacga agagaacggg cagcggagtt actatcaaaa cgaagttaag accgatgcct
    13861 gtttgcttca gcttcttgaa aacgctcggc aaggactacc ttattcaact ctttcggaac
    13921 aacttaagca ggcgggcgtc gacaccgata cggtcatgtc gtaccttgat gcgcttatcg
    13981 atagccaact tctggtatcg gatctgagca ttaacctgac cggacccgat ccgctggtac
    14041 ggctgaacga gcggctggcg acacgctcag gcaccggccc gcttgtggag cggctgacgc
    14101 acctgcaagc tctgctgccc tgctgcggcc caatgagcaa tcaacagata gaaacgctgc
    14161 tgcacgagct ggctgtatca gcacagccgc catatgtgca atgcgacact ttcttgcccg
    14221 acgataccct tgtgcttagc accgttgtgc aggccgagtt gggccatacg ctctccgatc
    14281 tggcagagcg tagccgccca tctgtcaact catcgctcga tacgtttaaa cgccgatttt
    14341 ttgcccgcta cgaaaatcag gctgtaccct tgctggaggc attagacccc gatgctggca
    14401 ttggctacga cctccatcag gaaatgccga cgccctggtt agatagtctg ccctggcatt
    14461 cggaggcttc atcggccccg gctgaaacgg ttgtttctga acatctactc aaactctacg
    14521 tctcggctat ccaacagcaa gaaatggtta ttcagcttac caaacaggat ttggatacta
    14581 ttctacctgt tcaacctaac ctcccactgc cgggtagtgg ctatgcaatc gggcagttga
    14641 tgggccagcc taacgcgccc gattcattat ttttgctgaa aggaatggga ggtccatcgg
    14701 cagcaaattt gctggggcga tttgcccacc tttcgcccga actcgaagcc cggctgaagc
    14761 agtgtctaca ggatgaacag gccatgtatc ccgatgcgtt gctggccgaa ctcgttcatt
    14821 tgcccggtgc ccgaaccggc aacgtactcc gtcggcctat attacggccc catgaactgc
    14881 cgatcttaac ccggtctatg gtgccagagt cgcaccagtt gtcgctccgg gagttgcgca
    14941 tagctgtgcc agatgggcag cgggtcgttt tgttgtcgca ccggctcaat cagcaggtta
    15001 taccaagact ttccacggcc cataatgtgc aggccggggg gtggctcatt ataggtttct
    15061 gtatgacctg caacagcagg aagccagttt acgcatagtc tgggattggg gaccactgaa
    15121 gaccatgccg tttttgccgc gcctaaccta tcgaaatgtg gtactcagcc gggcgcaatg
    15181 gcatctgcgt cgacaagatg ttgagactat acccagcacc gcgtgggtca actggcaaac
    15241 tgcccatcgg cttccacgct atgtgttgct ggcagaaggc gataacgaac tggtgatcga
    15301 tactgagata accgtggggt tacagttgct gacgcaggct ctccagcgca acggtcaggt
    15361 aacgctgctt gagtggcccg aggctgtaac ccggccactg gcgcactctg atcaggagca
    15421 gtactggagc cacgaattgt tgattccatt gcggaatacc actccgcagc caacgctggc
    15481 aaagctattg gcgacacctg tttctgcctc ggttcacgac cgtttgtttg cgcccggcaa
    15541 ccgctggctg tatcttaaac tatacgtagg ccctgccgca gccgacgcgt tactggccga
    15601 acacctaccg gccctgctgg cgagtttaca ggcacaaaac gcgctgcaat cttggttttt
    15661 tatccgctat gccgatccgg aaaaacacct tcggctccgt tttctggctt catcaggcca
    15721 gacagatact gttcttcagg ttattagcag ttgggccaac gcacgcatgg ccgccgacag
    15781 ccgcatttac cgcgtacagt tcgatactta tcagcgtgaa ctggagcggt tcggaccaaa
    15841 aactatcgaa atctgtgaaa cgtggttcgg ccacgacagc caagccattg tacaattact
    15901 gggctggctt attcaccaac ccgactggca gcggctccgg gtgggctgtt tgtttgtgca
    15961 tcagttgctt acgagttggg gctatactat cgccgagcaa cttgaacgaa tcgaagtctg
    16021 gcgcgatatg ttcctgcgcg agtttaaggc cgacaagttg tttcaacatg aagttaatgc
    16081 acaatttcgc gtataccggc ccttcctgga taagcccact ccaagcgagc cgatgttaca
    16141 gcaatggctg gcggtctacg gtgagcaggc tgctgctttt cagcaggaac tcaaacgggc
    16201 cgaccccgct tcacccaacc ggctgctacc gcacatcacc catttatttc ttaatcggct
    16261 gtttgccgat agtcagcgaa aacacgaaca aatcatctat tgcttcctgt ataagttgct
    16321 gaaacaatgg caacgaacct aacgctctca gctatagacc tacggtgtct ttgggaaacc
    16381 tcgcgtgttc gacctatcgc caacccactt ttgaaacaaa attaatgttg ggaatgcgat
    16441 tctgttgttt ctttgagggt atacatagaa aagtaaaaac aataggatcg cattcatgaa
    16501 tcaacctacg caaccccggt cccggcttcg ggcaacgctt ctgctaattg gcatcctcgg
    16561 cctgattctg accagcattt ttctcagccg cagcagtgtt ggccaaatcg aaaaatcagt
    16621 tgcctcgatt tacaaagacc ggctcgcccc aacagccatc cttgtgcatt taacgtcaaa
    16681 cctctacggc aaacggcttg tcctggaaaa ctacctgctc tctgccgaaa ggcccgaccc
    16741 aacgctgctg caaggccaaa tggaccgcag cgaccggcat accgactcgc tcctgaccga
    16801 gtttgagcaa acccggctca cccagcgcga ggccgaagaa ctccgggcct tccgtcagta
    16861 catcacggaa tataaccagt tagagaaaca ggtattgcaa caggctacaa ccaaccgcac
    16921 gcaggcccag aaaatgctgt ttacaggttc gggaaataca gcgtttgggc aggccgccac
    16981 caaactcgat gagttatcgg ccctgcaact gaccgttggc gaagaacttc tgagcgagtc
    17041 gcgcagtaac gtcgatcata tttacgtatt ctcggctttg caaatcggcc tgacgctgct
    17101 gattggcatc atcgtttttc ggcggggcat ttaaacctac tccagcaaca ccagtatatc
    17161 ttctttagtc agcgacttca tgaagttctc ttcggttgta atcaggctac cggccaattg
    17221 ctgcttggcc cgctgcaacg acagaatttt ttcctcgacc gtattcttgg caataaactt
    17281 gtacgtaaac acggttcgtt gctgaccaat tcgatgcgcc cggtcaacgg cctgcgcttc
    17341 tatggcgggg ttccaccacg gatcgagaat aaacacgtag tcagccgccg tgaggttgtg
    17401 gcccaaacca ccggccttga gcgaaatcag gaacagcttc accgaatcgt cggtctgaaa
    17461 cagctcgacc tgactttgcc ggtcggtggt tgagccgtct aagtaggcat atttgatgcc
    17521 gcgctcgttc aggtgttgtt caacaacgct caggtgcttg atgaattgac tgaatactaa
    17581 cactttgtgg tgttcggtca tggcactttc aagccgcagc agcacgtcat ccaatttgcc
    17641 agaatcgcct tcgtatccgg catcgaccat gcgcgggtgg ttggcaatct gccgcagttt
    17701 ggttagcccc tgcaatacaa tcatctgcga cttggccata ccatcttcct caattcgttc
    17761 cagaatcagg ttgcggtaat acgacttggc ctcttcatac tgctcggcct gatcgggcga
    17821 catgtcgcag tagagtacgc tctccacttt ttcgggcaaa tcagtagcta cctgcgcttt
    17881 gttgcgccgg agcataaatg gcttaatcag gctatataac cgattggtct ttgcttcgtc
    17941 gtgccgcttt tcgatgggta tctgaaattc atttctgaaa aacgactgac tccccagcag
    18001 tcccggatta ataaatgtca tctgactcca gaggtccatt gtgctgtttt cgagcggggt
    18061 tccggtcaga atcagccggt gcgccgtatt cagttgcatt acggcctttg tgatgtgcga
    18121 cgacgggttt ttgatggcct gcgactcatc taaaattaca tagttgaacc ggtaatcgct
    18181 caataaatcg atgtcgatgc gcacgatgcc gtatgaggtt agaatcaggt cgtagtcgtc
    18241 aaattgggcc gtgtttttct cccgatacgt accggtgtaa accatcacgc gcaggtcggg
    18301 ggtaaacttg cgggcttcga gttcccagtt gtagagcaac gacgtaggca tcaccagcag
    18361 gtttggccgg gcggcatcgg gttccgtatt ggcggcttcc ttttgccctt ccagcatggc
    18421 aagtgtcatc acggtcttgc ccaggcccat atcgtcggct aaacaaccac caaaccggta
    18481 ttggcgcagg aagttcatcc agtcgtaacc ggcctgctga taggggcgca gcgtgccatt
    18541 gaaatgcact ggaatcgggt acgattcgat ctccgaaaaa tcgcgcaggc gttcgagttt
    18601 gcggctcatc accgtagtgg cgaggttgtc gcgttcgagt tcctgtacga gcgcaaggtg
    18661 gtgtttgcgc agcacaagcc ggtcggcccc gtcggcatcg ataccacccg accgctccag
    18721 aaagccgaac agttcggagt agcgcgtaaa ccaggtttcg ggaattacgg ccacttcgcc
    18781 attggggagt gtaaattcgc gcttcttgtt gagaatgagc gttctgagct tcaaaaacgg
    18841 aatcacgaac tcgccaaact gtacattggc gtaaatatcg aaccaatcgc ggccttcttc
    18901 tatcgacacg ttaatgctcg aatagcccag aaaataccgc ttcgtatcct gcgcgtgttg
    18961 ttgcagcaca aacccggctt cctgaatttt ggcactgtta tcggccagcc atgcaaaagc
    19021 ttcggctttg gtcagggcca tacgcccgtg ccgcagatca agaccggctt cgcgcagagt
    19081 ggtcagtttt tgccgttcga gccgctgatc ccgacgaatc ttatgaaaaa tatactcgtc
    19141 gcctttttgt tctaaactga cattggccga cgggccgaaa ttatcgtacc gaaacataga
    19201 atcgccgtac cgaaacgaca ggtcgaacgc aattttccgg gtactttcgt ctgtctcgac
    19261 tacctctgcc gaattgcctt cgcgccctac tgcgagcgtt gacatgcttc ggctgctcgt
    19321 taccagttcc gacactgtca gcaccggttg aggctcaatc acttcgctgc gaatctcgaa
    19381 ccctttggca tatacgtcgt atgaggctat caactgcgtc acaaatcgtt cgtaatactg
    19441 tggttccaga ttgcgcggaa tcacgatatg gtttttggta aaaaacgggc ggagtttttt
    19501 gccatcaacg ttacggctaa attgatacag gcggttattt accagcaaac aggccggttc
    19561 gtcgcagacc ataagcgcgt ctttaaactg gaattctacg cgctcggttt cgccggttga
    19621 gccggttgga tagcgaataa tggggaagta atgcgttgaa tcggcattac gcacaaaatg
    19681 aaaatgtacc cgcgccggtt cgggcatcca cgtaattggt tgccaggccg ggttgccgtc
    19741 gttgcccatc acataaaatg gcttgcccgg cattagcgtc ataatttggg ctttcaggtt
    19801 ttcgagatac ccggcaatgg cttcctgtac taatttatcg cctttttggg cgtcgtagat
    19861 tttcagaaaa aaatcaacgg cgggcaatcg gcgggtgttg aatttcttaa caatggtatc
    19921 ctgttgaatg ctgtcgatga gccgcacaag ctcaaaatcg cgctcatcga gaccgcgcgc
    19981 aaactcgcct acgttttggg tcgacagcgt ttggttttgc aacgtcaatt cgccccggct
    20041 gttgcgttga accacgaagg cttcgatcag gtagcccaga aactcgtggt cgagcagcga
    20101 gtacacaatt tgaaagggtt gtgtggggtg aactttcatg caaaaacaca atttaccaga
    20161 ccagcctgca cacaggctat atcatagaaa aaacggatga ttggttatcg ataaacggcg
    20221 gggctgttcg ttaaaaggtt taaaccgcta atagataact gtttaagtcc attttttcag
    20281 aactaacggt ctcaaatata cgaatcaaac tatattctcc aagtgtatgt aaattaaatg
    20341 attttaactc aacaggttat gtcgcgtact tctgtttacg ggcggagttt ttgcgggatt
    20401 ccggctcaac aatcgcggct tttaacgtac tttggggtag caccatctga caaccgatgc
    20461 tttatgccca gtagtgaacc tgataaaacc cggcctattc aacgcaacga tagttttctg
    20521 cgcctacgca aagacaagct gatggtctac gtcgatccgc acttcggatt tatccggcag
    20581 gtgtataagg gcgtgttcta catcaagaaa tgtgcgtact gcaaacgcac gttcgaggct
    20641 aagcgcagac acgcggcttt ttgcagcccc acctgccagc aggcgcaccg ccggggacgt
    20701 aaccgctaac aattcgccga tgatgtggtt acactaccac atcactcgac attatgcatc
    20761 gttcgtttca ggttcagtta cctgccgata agacttccgc cgttatgaac gacctcctcc
    20821 agattgacga ggtcgttggt ttggccctct accccgacaa ttcgtataaa cctacgcccg
    20881 gcgacgtgct gtcggtacaa ctccttaacc ggggttccga taaggtgctg cgggccattg
    20941 ccaaccgctg tggcgatgca ccgtatctgg ttagcacctc gcttacggaa agcatcatcg
    21001 aaaccggcca atcagggaag ctcgaaaacg acctcgacga agccatttgg gaagaaattg
    21061 aaacgggcat gcgtcatcag gggcgcgtga cgttcaattt tgtggttctc atggcgcttg
    21121 gtggcattat ggcaaccatc ggtatcgttg ccgaacccac gcgacaggtg atgccgtttg
    21181 tggcagcggc cattattgcg ccgggtttcg agccggtggc agcgttgggg ctcgcgttgg
    21241 tactgcgccg atggattgtg ctatggcggg cgttccggtc gtcgttggtg gggtatagta
    21301 ccctcattgc agcttcagcc ctgacgtttc tgtttctgca agccattggc gaggccaccg
    21361 taagcgattt cgcgggcagc gaagaagtaa agcacctcgc ccaccccacc accgccgaca
    21421 cgctgctgtc ggtttgcggc accatttcgg gggccattat tatgtcgtcg tttcggaaga
    21481 gcgtgattgc cggggcgttg attgcgatgg tgattatcaa cgcagcagcc gtggttggca
    21541 tcggccttgc cagcggtcga tacgacttag ccggtcaggg tctgcaacgc ttcggcgtcg
    21601 acgtagcaat gattgtaggg gcctgtatgc tcgtgttctg ggccaaacag cagtttttcc
    21661 acaaccgcaa accgatagcg tgaatcaatt gtcccgtagg gacataacag cgcagcgtcg
    21721 gtagccgaaa cagcgaaccc ataaaacaac actcccggcc atgcctacgc acagccggga
    21781 gcgaaaaact tacaccttgt caccttatac cttaccactc acttaactcc cacacatctc
    21841 acagccttcc gggtcgtcca atgaacaggt catggcggca tattgctgct ccagttccgt
    21901 taccatcggt acgggggtag gttgttgatt ggtggcgtgg tctttggcgt actgcacgta
    21961 gtcgaggggt ttttcgacgg cgatggtttc ggccagtacg ggttccagtt gcggttcggc
    22021 ctgcggctct accgtgaact tcacagcatc ggcagcggct ttcgtgcgga ggtagtacat
    22081 gcccgttttc aggcccgctt tccaggcgta gaagtgcatc gacgtcagct tgccgaagtt
    22141 cgagtcctga atgtgaatgt tcagcgactg cgattggcag atatacgcgc cccggtcggc
    22201 ggccatgtcg atgatgtgct tctgcttaat ctcccacacc gttttgtaga ggtcgcgaat
    22261 gttttgcgga atgcccggca cctgctgcac cgagccgttg gcccgaatca ggttgttctt
    22321 catcgtgtcg ttccagaggc ccagcttcac gaggtctttg agcaggtgtt tgttcaccac
    22381 cacaaactcg cccgacagca cgcgccgggt gtagatgttg ctcgtgtacg gctcaaagca
    22441 ttcgttgttg cccagaatct gcgaggtcga cgcggttggc atcggggcca gtagcagcga
    22501 gttccgaacg ccgtgttcta ctacgtcttt gcggaggctc tcccaatccc agcggcccga
    22561 cttgggcgtt accggttttc cgtcgcgttc ccacatatcg aactggaaga taccctgcga
    22621 aatgggcgaa cctttccagg tttcgtaggg gccgtgttct ttcgccagtt ccatcgaggc
    22681 cgtcatggca ccgaagtaga tggtctcgaa aatgtcttca ttcagtcgac gggcttcgtc
    22741 gctctcaaac ggcattcgca acagaatgaa cgcatcggcc agcccctgta tgcccagccc
    22801 aatcgggcgg tgacgcatat tgctgcgccg ggcttcttca accgggtagt aattgaggtc
    22861 gatgattctg ttcaggttgc gggtggctac cttcgtaatc tcaagcagtt tctggtggtc
    22921 gaaccgcaga ataccgtcgg ggtcgcgctt gatgaacttc ggcagggcaa tgctggcaag
    22981 attacaaacc gccacctcgt cgggagccgt gtactcgatg atttcggtgc agagattgct
    23041 cgacttgatg gtgccgaggt ttttctggtt cgatttgcgg ttggccgaat ccttaaacag
    23101 catgtagggc gttccggtct cggtctgcga ctccagaact ttgaaccaca gttcctgcgc
    23161 tttgatggtt ttgcgggcgc ggccttcacg ctcataccgc tcatacagag cctcgaactc
    23221 ttcgccgtag caatcggcca gaccggggca ctcgtgcggg cagaacaaac tccacacgtc
    23281 gttgtcttct acgcgcttca tgaacaggtc gggcgtccag agggcataga acagatcgcg
    23341 ggcgcgggat tcctctttcc cggagttctt tttcaggtct aagaaatcga aaatatcggc
    23401 gtgccagggt tccagataca cggcaaacga acctttgcgt ttcccccctc cctgatcgac
    23461 gtagcgggcc gtatcgttga acacgcgcaa catcggaata atgccgttgg aggtgccgtt
    23521 ggtgcctttg atgtacgtac cggtggcccg aatgttgtga atgctcagac cgataccacc
    23581 cgccgactgc gagattttgg cggtttgctt cagcgtgtca taaatgccgt cgatgctgtc
    23641 gtctttcatc gtcagcaaaa agcagctact catctgcggt ttgggcgtac cggcgttgaa
    23701 gagcgtgggc gtagcatgtg taaaccactt ctcgctcaac aggttatagg tttctacagc
    23761 cgcgtcgatg ttgtctaagt gaatgcctac ggccacgcgc atgagcatgt gctgcgggcg
    23821 ttcggcgatg cgcccgttgg ttttcagcag atacgacttt tcgagggttt tgtagccgaa
    23881 ataatcgtag ccataatcgc ggtcatagat gatggtgctg tcgagcaggg cagcattggt
    23941 acgcaccacg tcgtagactt ctttcgagat cagcgacgca ttttcgcctg tttttgggtc
    24001 ctcgtagtgg taaagttgtt tgattgtacc ggagaacgat ttgttggttt ccttgtgcag
    24061 gtttgagata gcgatccggg cggccaggat ggcgtaatcg gggtggcggg tagtcaggga
    24121 ggcagccgtt tcggcggcta aattgtcgag ttcggtggtt ttcaccccgt cgtacaggcc
    24181 attaacgacc ttcatggcga cttctaccgg ctgcacatag gcagggtcaa ggccgtagca
    24241 cagcttctcg atacgagcgg taatcttatc gaacttgacc gactcccggc ggccatcacg
    24301 tttgattaca tacataatgt tctgggatta gtatagaaag aatgcgaaaa ttcagtgaaa
    24361 cgaagtttta aagttgcttt caaatagacg gaaaatcaac ccgtagggtt cagtcctttt
    24421 ttgacttcgg ggaaatgtgc aattctgcta tgtaggttaa gaaattgtta agcggtatga
    24481 atgaatcact tagcaataac ctatcaagag aatgatctaa aaaataaatc ttcggattta
    24541 ttttgcggca gagccgaacg gtgaatgcaa cgtagagaag ggtacctagt agtcgaaatg
    24601 taggaaaaat tgtcggtcgc tgcaagtcaa tattacggca ttattaggca acggccactt
    24661 ttaaaaattt gattgtcagg cactaaaaga agcccggaaa gaacttggca gagccagaaa
    24721 aaccccgtac ctttgcaatc cttttcggtc ggaaaccgag aagatgacag aaacagagga
    24781 tcagatcatg aaaaaaggca ttcacccgga ttaccgcgac gtggtattcc acgacctgtc
    24841 gagcgattac aaatttctga cgcgctcaac agttcaaacc agagacactg tcgagtttga
    24901 aggcaagacc tatccgctcg taaagattga agttagttcg cagtcgcacc cgttctatac
    24961 cggcaagaac gtactgctcg acacagcggg ccgcgttgat aagttccgca aacgctacgg
    25021 cacgaagtaa agtattagtt ttttagtaat aaaccccact atactggcta tagtggggtt
    25081 tattgtgttt tcctggcaag ttagaaaaat atatcacctc attgtctggc tcctgcccgt
    25141 tcaacggttc gctgcgtcgg cttagctgac gatagctggt agtgaatatg accgaccgtt
    25201 agtaggtagc cgaccagtgc cagcaggaca acgattaaaa taactttggt tgatcgcttc
    25261 attgcttcgc cagctatagt ttaataatgc tacaaactca tataaaacaa cccctgcgac
    25321 gaccagttta acaggggttg ttgcggttcg ttgtttacgc accatactgc gggttttgct
    25381 tcaaagcccg aaggattcgc ccacgtttgt aagagaaaaa cttgtactta cgcccatctt
    25441 ttagccgaac gacaaactta ttagggaaaa taaggagcgt atttcgtcga ctcactttgg
    25501 caatcgaact gagcggtact tgcacggctc tgaacaaatc attgtggcag ggatagattt
    25561 tacccagcag tttccagtcg aaacattcgg tagcagacat gaaccgtagc gaatcgctcg
    25621 taagcgttat gtcacctttg acaaaataca gaaaacctgg cagcagatgc gttttcagtg
    25681 taaccgtctg cgcggctggc gtaccttctt tcttctcagc tttggcaaac gtactaacgg
    25741 ttagcagtaa cgctatcaga ggtgcatgtg tctttttcat ttttctatat agttcaattg
    25801 acaatggcaa aatcttcatc gttgcaatga tgaagatttt gccattaaat taacttaaca
    25861 ggcacacgat gggagcgtac aacttaagtt cccgttatca tcaatgcact ctggacaaag
    25921 acagtcgcct tgtagtacgt tgattatgcc aacaactccg cccacaaccc ctccgagaat
    25981 gaccgtggca gcagccaact gttgcttgtc gataattggc ctttttctgc ttcgcttcat
    26041 aatccttctc accaacaccc ctgaccagca tagcgggggt gttggtgttt agacggagca
    26101 tttttaccaa cgtcattgcc aaagttccgg cccaatcacc cataaaagta gacccacaca
    26161 agtatagtgt atggccgtgt acacaagcca atatacaagt gctttccgtt tattttttat
    26221 aaagaaccgg aaaagcagaa acgtcaaaat tgatattacc aacgacgcta gaccccaaaa
    26281 tatgtaatta ttctccatag ttttgagcca taagccgtta attgcactta ctgtcgcaag
    26341 tt
//
