LOCUS       NZ_LZNS01000001        22007 bp    DNA     linear   CON 15-JUL-2024
DEFINITION  Streptomyces sp. MP131-18 scaf_01, whole genome shotgun sequence.
ACCESSION   NZ_LZNS01000001
VERSION     NZ_LZNS01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. MP131-18
  ORGANISM  Streptomyces sp. MP131-18
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7861428)
  AUTHORS   Paulus,C., Rebets,Y., Tokovenko,B., Nadmid,S., Terekhova,L.P.,
            Myronovskyi,M., Zotchev,S.B., Rueckert,C., Kalinowski,J. and
            Luzhetskyy,A.
  TITLE     New natural products identified by combined genomics-metabolomics
            profiling of marine Streptomyces sp. MP131-18
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7861428)
  AUTHORS   Tokovenko,B. and Rueckert,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-JUN-2016) Helmholtz Institute for Pharmaceutical
            Research Saarland, Helmholtz Centre for Infection Research, Campus
            C2.3, Saarbrucken 66123, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8
            Genome Coverage                   :: 72x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001984575.1-RS_2024_07_15
            Annotation Date                   :: 07/15/2024 02:52:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,130
            CDSs (total)                      :: 7,069
            Genes (coding)                    :: 6,890
            CDSs (with protein)               :: 6,890
            Genes (RNA)                       :: 61
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 55
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 179
            CDSs (without protein)            :: 179
            Pseudo Genes (ambiguous residues) :: 0 of 179
            Pseudo Genes (frameshifted)       :: 62 of 179
            Pseudo Genes (incomplete)         :: 155 of 179
            Pseudo Genes (internal stop)      :: 7 of 179
            Pseudo Genes (multiple problems)  :: 45 of 179
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:18:34
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3639390
            Orig. end                         :: 3661397
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LZNS01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22007
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /product="RiPP-like"
                     /region_number="20"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..22007
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="interleaved"
                     /product="RRE-containing"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..22007
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12007](-)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12007)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    complement(43..56)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.48"
                     /tool="antismash"
     misc_feature    complement(80..95)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.18"
                     /tool="antismash"
     gene            complement(328..1164)
                     /locus_tag="STBA_RS16205"
                     /old_locus_tag="STBA_32830"
     CDS             complement(328..1164)
                     /GO_function="GO:0004833 - tryptophan 2,3-dioxygenase
                     activity [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /GO_process="GO:0019441 - tryptophan catabolic process to
                     kynurenine [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016437236.1"
                     /locus_tag="STBA_RS16205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STBA_32830"
                     /product="tryptophan 2,3-dioxygenase family protein"
                     /protein_id="WP_077059934.1"
                     /transl_table=11
                     /translation="MSQPVTDFGQNETPYERYVQADVLTHLQRPLTDDPGEMAFLVTTQ
                     VMELWFTVLVHEWRTAVDALRADRLPAALAALGRSAHELRALNASWEPLAQLTPRQFNA
                     YRSALGEGSGFQSAMYRHVEFLLGEKSPSMLVPHQGTPRAHAELERALRAPSLYDEALA
                     YLARHGAAIPDEVLHRERTGRYEPHPAVEAAWRRIYAAGGDGGRGTGAESGPLRLGEAL
                     TEVAELVWRWRCDHLVATRRAMGGKAGTGGSSGVEWLEKRARRWVFPELWTARGRV"
     gene            complement(1261..1674)
                     /locus_tag="STBA_RS16210"
                     /old_locus_tag="STBA_32840"
     CDS             complement(1261..1674)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014144054.1"
                     /locus_tag="STBA_RS16210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STBA_32840"
                     /product="DUF3151 domain-containing protein"
                     /protein_id="WP_077059935.1"
                     /transl_table=11
                     /translation="MAIHEDLLGGPPPTHLPDDPEPRELLAAGTAPAEVAAKYPASSLV
                     WAQLADDAFAEGRSIESYAFARTGYHRGLDALRRSGWRGQGPIPFEHEPNRGFLRALHA
                     LARAAAAIGEQEEYERCAQFLRDSSPTAADTLS"
     misc_feature    complement(1668..1682)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.23"
                     /tool="antismash"
     gene            complement(1740..2762)
                     /gene="fbaA"
                     /locus_tag="STBA_RS16215"
                     /old_locus_tag="STBA_32850"
     CDS             complement(1740..2762)
                     /EC_number="4.1.2.13"
                     /GO_function="GO:0004332 - fructose-bisphosphate aldolase
                     activity [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fbaA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006347787.1"
                     /locus_tag="STBA_RS16215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STBA_32850"
                     /product="class II fructose-bisphosphate aldolase"
                     /protein_id="WP_077059936.1"
                     /transl_table=11
                     /translation="MPIATPEVYNEMLDRAKAGQFAYPAINVTSTQTLHAALRGFAEAE
                     SDGIVQISTGGAEFLGGQYSKDMVSGATALAEFAHVVAQKYPVNIALHTDHCPKDKLDG
                     YVRPLLAISEERVARGENPLFQSHMWDGSAETLRDNLEVAEELLARAAAAKIVLEVEIT
                     PTGGEEDGVTHEINDKLYTTVEDALRTAEALGLGERGRYLLAASFGNVHGVYKPGNVVL
                     RPELLKDLQEGVAAKHGKASPFDFVFHGGSGSTREEIATALGNGVVKMNLDTDTQYAFT
                     RPIVDHAFRNYDGVLKVDGEVGNKKAYDPRSWGKLAEAGMAERVTQACGDLRSTGTRLK
                     "
     misc_feature    complement(2847..2859)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.27"
                     /tool="antismash"
     misc_feature    complement(2869..2882)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 21.68"
                     /tool="antismash"
     gene            complement(2971..3513)
                     /gene="pyrE"
                     /locus_tag="STBA_RS16220"
                     /old_locus_tag="STBA_32860"
     CDS             complement(2971..3513)
                     /EC_number="2.4.2.10"
                     /GO_function="GO:0004588 - orotate
                     phosphoribosyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009220 - pyrimidine ribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pyrE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004945786.1"
                     /locus_tag="STBA_RS16220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STBA_32860"
                     /product="orotate phosphoribosyltransferase"
                     /protein_id="WP_077059937.1"
                     /transl_table=11
                     /translation="MSVRDELLQQIKDKAVVHGRVVLSSGREADWYVDLRRVALDGEAA
                     PLVGRTMLDLTADLEYDAVGGLTLGADPVATAMLHAAAAAGRRLDAFVVRKAGKAHGLQ
                     RRIEGPDVAGRRVLAVEDASTTGSSVLTAVEALREAGAEVVAVAVIVDRGAAAAVARTG
                     LAYRSAFTLDDLGLADA"
     protocluster    3070..15004
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[8069:10004](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(8070..10004)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
     misc_feature    complement(3479..3492)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.35"
                     /tool="antismash"
     gene            complement(3525..4340)
                     /locus_tag="STBA_RS16225"
                     /old_locus_tag="STBA_32870"
     CDS             complement(3525..4340)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014053796.1"
                     /locus_tag="STBA_RS16225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STBA_32870"
                     /product="aldose epimerase"
                     /protein_id="WP_077059938.1"
                     /transl_table=11
                     /translation="MTTHDSDRGVRLRAADAELTLRPDQGGRISSLRVGGTELLRQGER
                     FGSFIMAPWCGRTREGRFRNGATAHELPLNAAPHAIHGTVRRRPWRTVRADDTSAALIC
                     ELAEPWPYAGRVTQLVELAEDGSGLTCTLGVETDGDSFPAQAGWHPWFLRSLRPGGPGV
                     EIGFDAEWQEERGADHLPTGRRTAPGPGPWDDCFGMPDGVDVTLTWPGHLELNVRSRSP
                     WAVIYDEQAEAVCVEPQSGPPNGLNTHPRLVTPLEPLEISTTWTWRTLP"
     misc_feature    complement(4361..4377)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.27"
                     /tool="antismash"
     gene            complement(4405..5412)
                     /locus_tag="STBA_RS16230"
                     /old_locus_tag="STBA_32880"
     CDS             complement(4405..5412)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019355042.1"
                     /locus_tag="STBA_RS16230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STBA_32880"
                     /product="hypothetical protein"
                     /protein_id="WP_077059939.1"
                     /transl_table=11
                     /translation="MEHEVFLPYSAEAVRSALAAPERVVRCVPGLHLEPGADPAAPEGR
                     LRVRIGSSSITYRGSMSVTARGDRLTVEAQGTEARGAGEAALMLSVVPREVEDGSGTAL
                     TFHGTVEGKGRIGTFDAGQRQAAGRRLLDRFAEALAEELARADEPAPAAGGIGEPDDNE
                     RVIPGIPSAPEPEPEPGAGSGRAARAGGNETGAGAESDHDAAFDAVLGAEPGPGRDPDA
                     DAVADAGLGSDRGFDGGDLDADLDSGLDRDLDPGLDDEEDLPVHEPEADFARRTMIGRS
                     AEEVDHAPPRGRYAPEPTPGGAPGPAAALRWAAPAAALAVATAVVLTRAIRRRR"
     gene            complement(<5564..6298)
                     /locus_tag="STBA_RS16235"
                     /old_locus_tag="STBA_32890"
                     /pseudo=""
     CDS             complement(<5564..6298)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003979922.1"
                     /locus_tag="STBA_RS16235"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="STBA_32890"
                     /product="spermidine synthase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MIDTTGQAAAPRSATAVLPVSAGAGRLVVLVAVFVCAACGLVYEL
                     ELIALADYLVGDTVTHTSIVLSLMVFAMGIGSLAAKRLREHAALNFGLIESLLALVGGC
                     SATVLYVSFLLFGEARPALLAFSLAIGVLIGAEMPLLMTLIQRIREQDAGRAVADLSAA
                     DYVGALLGGLAFPFLLLPLLGQLSAALCTGVVNALAGAVIVLWLFRGDLSRAARRRLML
                     LNAGVIAVLVSCSAAVDPLERAA"
     gene            complement(6295..6867)
                     /locus_tag="STBA_RS16240"
                     /old_locus_tag="STBA_32900"
     CDS             complement(6295..6867)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471914.1"
                     /locus_tag="STBA_RS16240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STBA_32900"
                     /product="DUF2617 family protein"
                     /protein_id="WP_077059941.1"
                     /transl_table=11
                     /translation="MLTTIYTAFTDTRAGDLAWALGREPLPSLATLDVELAGAHIQLRV
                     LGASHQVLLDCREGTCSETVACMPGSNTPLPLGVSKRLGNFEYEFAARVESLSVGSFAG
                     RAQELLALVAEHPYGLAGLFPGDPNAFTALLVQRRGGQFHWRTWHAYPQERCLVATRTR
                     VSGATDHPKSTPVGDKANPKCDVTFGS"
     gene            complement(7199..7963)
                     /locus_tag="STBA_RS16245"
                     /old_locus_tag="STBA_32910"
     CDS             complement(7199..7963)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.4"
                     /locus_tag="STBA_RS16245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STBA_32910"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_077059942.1"
                     /transl_table=11
                     /translation="MSTPTALPGTRAHAFRLLGPFTFIREGALPRPMWPKPRALLALLL
                     VAEGPVTLERIGAELWRGRPPDSAVANIRGYIGLLRREVGAAAVRTGLGAYELALPQAR
                     VDAEEFRGLVDRAEVTACPRQRRELLEGALGLWRGPALSGIEHGPLLESWVERMNGHRR
                     RALLQVAELSLEAGQYARAQDVLRQHLVGSPTDEAAYQLLMRALHGAGDSSAALAVYQQ
                     ANRRLVDHGLFPGPQLRGMQQAILSHLPLPTC"
     gene            complement(8070..10004)
                     /locus_tag="STBA_RS16250"
                     /old_locus_tag="STBA_32920"
     CDS             complement(8070..10004)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03604.1"
                     /locus_tag="STBA_RS16250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STBA_32920"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_079251960.1"
                     /sec_met_domain="TIGR03604 (E-value: 8.3e-74, bitscore:
                     247.3, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 3e-51, bitscore: 173.7,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSPEAMPTRARICVLGSGGALYDAVLARSGGTAGPRTLLVAVHE
                     GWDTALHDTARRTAADHGIGWLPVRTELSHAVVGPLEVPGGTGCADCATARARRIRPDQ
                     DERDAVRRRHGRALAATAPSWLTGTAAGLVAGLVAEEAERLSGAEPGAPRTRKALLRVA
                     LDDLSVTRHPFLPEPLCEVCGDVPADTAEGAVPALTARSAHRPGRFRARPLRDALCELT
                     DAYVDDQVGLIASLDGHRVGGLVVTSAPVGFRTGRVTAGRGHAPTARTSRLSALLGAVE
                     RYGNAPGGRSAAVTATFRELGDRALDPRAADPFAPEPCQDRPLAWVWGWSFARRESVLV
                     PQSLAYRDPAAGGQAEGPGGSAVGGSLEEAILHGLLQVARRDALLMTWYARLAAAEIDL
                     AAAADRAVPLLAATVRAETGYRVRAFDVSAEQGIPCVWALAENPAGNGGPAVACAGGAH
                     PDPEKAIRRALHDLGPALAALLDGYAEAGAAELARRMAEAPELVRTAEQHALLYGDPGA
                     AARLRFLTSAAPSRKPVDIGAERGGFAGDDLLGHLLEAVGRYTAGGMDVVVVDQTAAEH
                     AAGGLACVNVLVPGTVPLTYGHARRRMDRLPRLAEVPVRLGHRTSPLPPADVNPHPHPF
                     GGRGSAPGA"
     gene            complement(10001..12007)
                     /locus_tag="STBA_RS16255"
                     /old_locus_tag="STBA_32930"
     CDS             complement(10001..12007)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Heterocycloanthracin_C_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="STBA_RS16255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="STBA_32930"
                     /product="hypothetical protein"
                     /protein_id="WP_077059943.1"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 6.9e-18,
                     bitscore: 63.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     1.5e-10, bitscore: 39.4, seeds: 5, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPIVRHDVYHAATGDGAYLLTPRGAVRLAGEAVGPWLDRLLPSL
                     DGSRTVAELTEGLPPDQQEFVERMLRRLRAAGVVRDAAPTRHAELTAAEAEEYAQEIAH
                     ITGFTEDDATAAFVRHRAQRTLVAGEGPLLEAVAGAAVASGLRTVRVVAFDDGGGPRPR
                     PRDSGQRLTWERHPEPRDAEAMTALLDRADLVLHVTSRPADRALLVERCAARTGVPLAQ
                     AVVRGPEAWLIPLQRWTGTGGAPGRWAAALPRLAAPAETVTAAPGPAARLAVAARLVQS
                     VFHVVTGAEPAPDRSELITIDLATLAGRRRPFLPHPVALPAPAPDRPRFAERIRALRRG
                     PRLSGQAFAQRAASCADDRLGIFRFVDTDWAQSPLHVARAVVTRRPQLSAIGFGFGELQ
                     ARHQAALSALARYAAGQFDARRLPGHADGGNGEHGAGAAGPDEPQGPAVLGYELADPGR
                     VHRVPVADAFPGLRPWRPSDDPFSPVVGGQDWQEAVTAGLLAHCRLLTLVRMRETTRPY
                     PRVPLDEAPLGREGARCRDILAELDELPETYDVTGQLGVPTYAFCRGPVTVACAAGLTA
                     AAALTDGLRQVLLGVQARAHLQTGYAPFPVVPGLPHALRSRDAHTPAVNPPLDVAAVAA
                     RLDALGHTAVAVPLDHDPAVAELMPYLVHVVVL"
     aSDomain        complement(11738..11986)
                     /aSDomain="Heterocycloanthracin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing C protein in a
                     heterocycloanthracin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_STBA_RS16255_Heterocycloanthracin_C_R
                     RE.1"
                     /evalue="6.10E-13"
                     /identifier="RREFam011.1"
                     /label="STBA_RS16255"
                     /locus_tag="STBA_RS16255"
                     /protein_end="90"
                     /protein_start="7"
                     /score="39.4"
                     /tool="antismash"
                     /translation="DVYHAATGDGAYLLTPRGAVRLAGEAVGPWLDRLLPSLDGSRTVA
                     ELTEGLPPDQQEFVERMLRRLRAAGVVRDAAPTRHAEL"
     aSDomain        complement(11765..12001)
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_STBA_RS16255_Thiopeptide_F_RRE.1"
                     /evalue="2.80E-20"
                     /identifier="RREFam004.1"
                     /label="STBA_RS16255"
                     /locus_tag="STBA_RS16255"
                     /protein_end="81"
                     /protein_start="2"
                     /score="63.1"
                     /tool="antismash"
                     /translation="PIVRHDVYHAATGDGAYLLTPRGAVRLAGEAVGPWLDRLLPSLDG
                     SRTVAELTEGLPPDQQEFVERMLRRLRAAGVVRD"
     misc_feature    complement(12055..12071)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.84"
                     /tool="antismash"
     gene            12403..15315
                     /locus_tag="STBA_RS16260"
                     /old_locus_tag="STBA_32940"
     CDS             12403..15315
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013124.4"
                     /locus_tag="STBA_RS16260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STBA_32940"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_077059944.1"
                     /transl_table=11
                     /translation="MVEIRLLGSVELRAANGARLDPGPPQQRCVLAVLAMSPGRAVTAE
                     TLIDRVWPRQPPENVRDVLYTYISRLRRVLRRLGDGAGSPVLRRGDGGYLLDVPQDAVD
                     LHRARRLAAQAAHVTGDQGGTAGAGGADAERAAELLAEAAALWRGTPLSGLRGEWAEGV
                     RGGLERELVTLLTDRFAQELRLARHADVVPALSAAVLDHPLAEPLAEQLMLALYRSGRQ
                     ADALAAYTRTRQRLAAELGAEPGAALRRLHQRILRRDPGLGARAAATDARPSQLPPDVT
                     SFTGRAAEIRELDGLLPREGEGGRSAAVIVTVNGSAGIGKTTLAVHWAHRVAAHFPDGR
                     LYVDLRGLGATGEPLDASDALRGILSALRVPPQRVPADLDSQAALYRSLLAGKRMLVVL
                     DNARDTAQCRPLLPGSPGSLAVVTSRNRLLGLVASLGARAVNLDLFTRDEAWQMLADRL
                     GPRRLAADARAVDGIIDTCARLPLALAVVAAQAAAAPERPLAELADGLRGPEPLNALAG
                     EAGEAAEEAGAAGAATDIRALFSWSYRALSPAAARLFRLGGLHPGPDLTPVSAAALTGL
                     PPRSARAQLAELSRAQLLTEREPGRYAMHDLLRAYARELTAATDDAAERRAATRRVLDY
                     YLHSAHRAHQQLGPSWRQPTDLGTPRDGIAVETFADEAAAVAWFTAERACLLDAFEGAA
                     AEEFDTLVCALAWVLTGLLDRQGHWHDLARVQDTAFDASLRLGELGEQARALNNKARLS
                     TRFLHYDEALSLLRDALDLLEAIDDRQGQAETHQHLGFVLENRGRLPEALGHERRALAL
                     YRAAGNRPDEARSLNVVGWLLARLGEHREALDYCRQALRLQQEGDDALGLAATLDSLGY
                     VQHHLGAWPDALRAYERALSLLRGPGLGDRSLEAALLQRLGDTHRALGNDAAAGEAWTD
                     ALRIMEELGSPDVAEVLTRLRDLGVGPERLRAYPSSRPPG"
     misc_feature    12838..12840
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15288..15611)
                     /locus_tag="STBA_RS16265"
                     /old_locus_tag="STBA_32950"
     CDS             complement(15288..15611)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003982605.1"
                     /locus_tag="STBA_RS16265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STBA_32950"
                     /product="MTH1187 family thiamine-binding protein"
                     /protein_id="WP_077059945.1"
                     /transl_table=11
                     /translation="MIVAFSVTPIGTGENVGAEVAEAVRVVRESGLPNRTDAMFTSVEG
                     EWDEVMAVVKQAVEAVTARAGRVSLVLKADLRSGVTDGLTGKVERVEQLLAAPDQPGGR
                     EEG"
     gene            complement(15608..16252)
                     /locus_tag="STBA_RS16270"
                     /old_locus_tag="STBA_32960"
     CDS             complement(15608..16252)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020665480.1"
                     /locus_tag="STBA_RS16270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STBA_32960"
                     /product="YbjN domain-containing protein"
                     /protein_id="WP_077059946.1"
                     /transl_table=11
                     /translation="MSVDPSAIPNFGGKPGKPDKQGQPQQAGRPTGPIMPNQELVKQLL
                     DRMKLKHTVDKSGDLLAPWKHYRVYFMFRGEERQRVLTVRTFYDRQHTVDDKPRLLQAI
                     DEWNHSTLWPKVYTHTSDDGTVRLVGDFQLLLGAGVGFDHFVASVVSWVRAAGEFDKWL
                     VDRFGLAKDEDDEPTEDARNAEGAGDPAASGDSGDAGTAGGPTGEGTGTAP"
     misc_feature    16258..16275
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     misc_feature    complement(16354..16373)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.37"
                     /tool="antismash"
     gene            complement(16363..18957)
                     /gene="clpB"
                     /locus_tag="STBA_RS16275"
                     /old_locus_tag="STBA_32970"
     CDS             complement(16363..18957)
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_process="GO:0009408 - response to heat [Evidence IEA]"
                     /GO_process="GO:0042026 - protein refolding [Evidence IEA]"
                     /codon_start=1
                     /gene="clpB"
                     /gene_functions="other (smcogs) SMCOG1223: ATPase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471918.1"
                     /locus_tag="STBA_RS16275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STBA_32970"
                     /product="ATP-dependent chaperone ClpB"
                     /protein_id="WP_077059947.1"
                     /transl_table=11
                     /translation="MNAELTNRSRDAISAANDRALTGGHPDITPAHLLLALLTGQDNEN
                     IQDLLVAVDADQAALRSGAERLLTGLPSVQGASVAKPQPNRELLAVVADAAQRAKELGD
                     SYVSTEHLLIGLAAKGGQTAELLAAQGAADRKLLDAFEASRGGQRVTTADPEGTYKALE
                     RFGTDFTAAAREGRLDPVIGRDHEIRRVVQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQ
                     RMVKGDVPESLKNKRLVALDLGAMVAGAKYRGEFEERLKAVLGEIKDSHGQIVTFIDEL
                     HTVVGAGAGSDSAMDAGNMLKPMLARGELRMVGATTLDEYRERIEKDAALERRFQQVLV
                     AEPGVEDSIAILRGLKGRYEAHHKVQIADGALVAAAALSDRYITSRFLPDKAIDLVDEA
                     ASRLRMEIDSSPVEIDELQRSVDRLKMEELALANESDASSQERLARLRRELADREEDLR
                     GLTARWEKEKQGLNRVGELKERLDESRGLAERAQRDGDFEAASKLLYGEIPALERELAA
                     ASEAEREAKRDTMVKEEVGPDDIADVVSAWTGIPAGRLLEGETEKLLRMEEQLGRRLIG
                     QHEAVRAVSDAVRRSRAGVADPDRPTGSFLFLGPTGVGKTELAKALADFLFDDERAMVR
                     IDMSEYSEKHSVARLVGAPPGYVGYEEGGQLTEAVRRRPYTVVLLDEVEKAHHEVFDIL
                     LQVLDDGRLTDGQGRTVDFRNTILVLTSNLGSQHLIDPLTKPEQQREEVLAAVRTAFRP
                     EFLNRLDDLVVFSALTGPELSRIARLQTDALQRRLADRRLALEVTEPALRWLSDEGNDP
                     AYGARPLRRLVQTAIGDPLARKILAGEVRDGDTVRVDAALDGGLVITADGRE"
     misc_feature    complement(18950..18961)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     misc_feature    complement(18987..19000)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.82"
                     /tool="antismash"
     gene            complement(19147..19932)
                     /locus_tag="STBA_RS16280"
                     /old_locus_tag="STBA_32980"
     CDS             complement(19147..19932)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024758.4"
                     /locus_tag="STBA_RS16280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STBA_32980"
                     /product="trypsin-like peptidase domain-containing protein"
                     /protein_id="WP_079251961.1"
                     /transl_table=11
                     /translation="MRIARSPIPVALAAVLLAFGARPAAAAQPWAEGPVGTVGKLMWDA
                     GGGRLGLCSGAVVDAPNGSVVATAAHCVRTAAGPEPPKEVWFVPGYHHGRDTYREDGWL
                     VTGFHTPEGWDVTRETSAILPHDYAFLTLGRRDGRTVQEVHGANRLAFEPVAEGGRVAV
                     LGYPAVEPYDGETLHYCAGETDVLTAGEAEEPNLGGLLLSGCDLTAGSSGGPWLTDYDP
                     ATGSGTLVAVMSVGSGQGHVVGRPYPEGARSLFAAAGGG"
     misc_feature    20053..20068
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.47"
                     /tool="antismash"
ORIGIN
        1 atcgagatcg accgcgccga cggccgaacg gccgtgttca cggtggactc ggtcgagcag
       61 tacccgaagt ccgactttcc cgaccagcgg gtctacggcg cggtcggcac cccgcagttg
      121 cggctgatca cctgcggcgg ccggtggacg caggacggcg gctacgactc caacatcgtc
      181 gcgtacgccc ggctgaccgc cactgccggc caggacaccg ccgcgccgcc cacgcccgcg
      241 ccggaaccgg tgcccgtgcc cggcgttccc gccgggtgaa cggccccccg cgccgcggcc
      301 ccgaccgggc cgcggcgccg cacgctttca cacccggccg cgcgccgtcc acagttcggg
      361 gaacacccac ctgcgggccc gcttctccag ccactccacg ccggacgaac cgccggtgcc
      421 cgccttgccg cccatcgcgc ggcgggtcgc caccaggtgg tcgcaccgcc agcgccacac
      481 cagctcggcc acctcggtca gcgcctcgcc cagccgcagc ggtccgctct ccgcaccggt
      541 cccccggccg ccgtcgccgc cggccgcgta gatccgccgc cacgccgcct ccaccgccgg
      601 atgcggctcg taccgcccgg tgcgctcccg gtgcagcacc tcgtcgggta tcgccgcgcc
      661 gtgccgggcc aggtacgcca gcgcctcgtc gtacaggctc ggcgcgcgca gcgcccgttc
      721 cagctcggcg tgcgcccggg gcgtgccctg gtgcgggacc agcatcgagg gcgacttctc
      781 gcccagcagg aactccacgt gccggtacat cgccgactgg aaccccgagc cctcgccgag
      841 cgcggaacgg taggcattga actgccgcgg tgtcagctgc gccagcggct cccacgaggc
      901 gttcagcgcc cgcagctcgt gcgccgagcg gccgagcgcc gccagcgccg cgggcagccg
      961 gtccgcgcgc agcgcgtcca cggcggtgcg ccactcgtgg acgagcacgg tgaaccacag
     1021 ctccatgacc tgtgtcgtga ccaggaacgc catttcgccc ggatcgtcgg tcagcggtcg
     1081 ttggaggtgg gtcagcacgt ccgcctggac gtagcgctcg tagggggttt cgttctgtcc
     1141 gaaatcggtc accggttgcg acatcgttgt ctcctcacgg cttggtcgcc gtcagggtac
     1201 gggtgccgac ggacaaggcg ccccgcttcg tcacggggcg ccctcggtgg gagatctccg
     1261 tcaggacagg gtgtcggccg ccgtcgggga gctgtcgcgg aggaactgcg cgcagcgttc
     1321 gtactcctcc tgctcgccga tggccgccgc ggcacgggcc agcgcatgga gtgcgcgcag
     1381 gaagccgcgg ttcggctcgt gctcgaacgg gatggggccc tggccgcgcc agccgctgcg
     1441 ccgcagcgcg tcgaggccac ggtgatagcc ggtgcgcgcg aaggcgtacg actcgatgct
     1501 gcggccctcg gcgaacgcgt cgtccgccag ctgggcccag accagcgagg acgccgggta
     1561 cttcgcggcc acctcggcgg gggccgtacc ggccgcgagc agctcgcggg gctccggatc
     1621 gtcgggcagg tgcgtcgggg gcgggccccc gagcaggtct tcgtgaatgg ccatgatgtc
     1681 cagtctgccg ggtccgcggt ggaaggccca gttgcttcct gtgcctcctg gcggacgcgt
     1741 tacttgagcc gggtgcccgt ggagcgcagg tcgccgcacg cctgggtgac ccgctcggcc
     1801 atcccggcct cggcaagctt gccccagctg cgcgggtcgt acgccttctt gttgccgacc
     1861 tcgccgtcca ccttcagcac gccgtcgtag ttgcggaagg cgtggtcgac gatgggccgg
     1921 gtgaacgcgt actgggtgtc ggtgtccagg ttcatcttca ccacgccgtt gccgagcgcg
     1981 gtggcgatct cctcgcgggt ggagccggag ccaccgtgga agacgaagtc gaacgggctc
     2041 gccttgccgt gcttcgcggc cacgccctcc tggaggtcct tcagcagctc ggggcgcagc
     2101 acgacgttgc ccggcttgta cacgccgtgc acattgccga aggaggcggc gagcaggtac
     2161 cgcccgcgct cgccgaggcc cagggcctcc gcggtgcgca gggcgtcctc gacggtggtg
     2221 tacagcttgt cgttgatctc gtgggtgacg ccgtcctcct caccgccggt cggggtgatc
     2281 tccacctcca gcacgatctt ggcggcggcg gcccgggcca gcagctcctc ggcgacctcc
     2341 agattgtcgc gcagcgtctc ggccgagccg tcccacatgt gggactggaa cagcgggttc
     2401 tcgccgcggg cgacgcgctc ctcggagatg gcgagcaggg ggcgcacgta gccgtccagc
     2461 ttgtccttcg ggcagtggtc ggtgtgcagc gcgatgttca ccgggtactt ctgcgcgacg
     2521 acatgcgcga actcggccag cgccgtggcc ccggagacca tgtccttgct gtactggccg
     2581 cccaggaact cggcgccgcc ggtggaaatc tgaacgatgc cgtcgctctc cgcctcggcg
     2641 aagccgcgca gcgcggcgtg cagcgtctgc gtcgaggtga cgttgatggc cgggtaggcg
     2701 aactggcctg ccttcgcccg gtcgagcatc tcgttgtaga cctcgggggt cgcgatgggc
     2761 atgtccgctc cttgtgttct tgccgtgtgc gtggcgttcg actgcccgaa tatcctccca
     2821 gacgcccgca gccaccggga cagcgcgcga cagtttcacg tgaaacaatc acgcagggtg
     2881 ataatcgctg gccggggcgg ccacgtcgca ccgcgcgccc ggcgcgccgc ggggccgcaa
     2941 gccgggggca ggcacgagcc aagccgcgct tcaggcgtcg gcgagcccca gatcgtccag
     3001 cgtgaacgcg gaacggtagg cgagccccgt ccgcgccacg gccgccgccg ccccgcggtc
     3061 gacgatcacc gcgacggcca ccacctcggc ccccgcctcg cgcagcgcct ccacggccgt
     3121 cagcacggaa ctgccggtgg tggaggcgtc ctcgaccgcg agcacacggc gcccggccac
     3181 gtcggggccc tcgatccggc gctggagccc atgggccttg cccgccttgc gcaccacgaa
     3241 cgcgtccagc cgccgaccgg ccgccgcggc ggcatgcagc atcgccgtgg ccaccgggtc
     3301 cgcgcccagg gtgagcccgc cgaccgcgtc gtactccagg tccgcggtca ggtccagcat
     3361 cgtccggccg accagcggcg cggcctcgcc gtccagggcc acccggcgca gatcgacgta
     3421 ccagtcggcc tcccgcccgg aggagagcac cacccggccg tgcaccacgg ccttgtcctt
     3481 gatctgctgc aacagctcgt cacgcacgct catggcaccc gaccctacgg cagcgtccgc
     3541 caggtccagg tcgtggagat ctccagcggt tccagcgggg tgaccaggcg cgggtgtgtg
     3601 ttgaggccgt tgggtggccc cgactgcggc tccacgcaca ccgcctcggc ctgctcgtcg
     3661 tagatcaccg cccacgggct ccggctgcgg acgttcagct ccaggtgccc cggccaggtc
     3721 agggtgacgt ccaccccgtc cggcataccg aagcaatcgt cccaggggcc gggcccgggc
     3781 gcggtgcgcc ggccggtcgg caggtggtcg gcgccccgtt cctcctgcca ctcggcgtcg
     3841 aagccgatct ccacgccggg gccgccgggg cgcaggctgc gcaggaacca cggatgccag
     3901 ccggcctggg ccgggaagga gtcgccgtcg gtctccacgc cgagcgtgca tgtcagtccg
     3961 ctgccgtcct cggccagctc gaccagctgg gtgacgcggc cggcgtacgg ccagggctcc
     4021 gccagttcac agatcagcgc cgccgaggtg tcatccgccc ggacggtgcg ccaggggcgg
     4081 cggcggacgg tgccgtgaat ggcgtgcggg gcggcgttca gcggcagttc gtgcgccgtg
     4141 gcgccgttcc tgaaccgccc ttccctggtc ctgccgcacc agggcgccat gatgaaggag
     4201 ccgaaccgtt cgccttggcg caacagctcg gtaccgccga cccgcagcga ggagatacgg
     4261 ccgccctgat cggggcgcag cgtcaactcg gcgtcggcgg cgcggagtcg tactccgcga
     4321 tcggagtcgt gggtggtcac cccatgacga taacgattcg atgtacgtaa atcataatgg
     4381 cgcccttgtg tggggcgccc tgcgtcaccg gcggcggcga atggcccgcg tcagcaccac
     4441 ggccgtggcc acggccagcg cggccgccgg ggccgcccag cgcagcgccg ccgcggggcc
     4501 gggggcgccg ccgggcgtgg gctcgggggc gtaccggccg cgcggcgggg cgtgatccac
     4561 ctcttccgcg ctgcggccga tcatggtgcg ccgggcgaag tccgcttcgg gctcgtgcac
     4621 cggaagatcc tcctcgtcat cgagacccgg gtcgaggtca cggtcgagac cggagtcgag
     4681 gtcggcatcg aggtcgccgc cgtcgaaccc gcggtcggac cccagacccg cgtcggcgac
     4741 cgcgtcggcg tccggatcgc ggccggggcc gggctccgcc cccagcacgg cgtcgaaggc
     4801 ggcgtcgtgg tcggactcgg cgccggcccc cgtctcgttg ccgcccgcgc gcgccgcacg
     4861 cccggacccg gcgccgggct cgggctccgg ctcgggggcg gacggaatgc cgggaatgac
     4921 ccgctcgttg tcgtccggct ccccgatgcc gccggccgcg ggggcgggct cgtcggcccg
     4981 cgccagctcc tcggccagcg cctcggcgaa acgatccagc aggcgtcggc ccgccgcctg
     5041 ccgctgacct gcgtcgaagg tgccgatgcg ccccttcccc tcgacggtgc cgtggaaggt
     5101 cagcgcggtg ccggagccgt cctcgacctc gcgcggcacg acgctgagca tgagcgccgc
     5161 ctcgccggcg cccctggcct cggtgccctg cgcctcgacg gtgaggcggt cgccccgggc
     5221 cgtcaccgac atggagccgc ggtaggtgat gctggaggag ccgatgcgca cccgcagcct
     5281 gccctcgggt gcggccgggt ccgcgccggg ctccagatgg agcccgggaa cgcaccggac
     5341 cacccgctcg ggcgcggcga gcgcgctccg cacggcttcg gcggaatagg gcaggaagac
     5401 ctcgtgctcc atggcgcgga gcctacccac tgcccggcac ataaggcacc ggtcgcgcca
     5461 aatgccaccg cccgcgccgt ggcgctcacg gtggggtcac ggcgagggcc gcggcgcggg
     5521 cgtgctgcga ctcgggcgcc gggctctcgc tgatccgctc ggccgccgcc cgctccagcg
     5581 gatcgacggc cgcggagcag gacaccagga cggcgatcac ccccgcgttc agcagcatga
     5641 gccggcgccg cgcggcgcgg gagaggtctc cgcggaacag ccacaggact atgaccgcgc
     5701 cggccagcgc gttgaccacg ccggtgcaca gcgccgcgct gagctgcccg agcagcggca
     5761 gcagcaggaa cgggaaggcg aggccgccga gcagcgcgcc cacgtagtcg gcggcggaca
     5821 ggtcggccac cgcgcggccg gcgtcctgct ccctgatgcg ctggatcagc gtcatcagca
     5881 gcggcatctc cgcgccgatc agcacgccga tggcgaggga gaacgcgagc agcgccggtc
     5941 tcgcctcgcc gaacagcagg aaggagacat acagcacggt cgccgagcag cccccgacca
     6001 gcgcgagcag cgactcgatc agcccgaagt tgagcgcggc gtgctcccgc aggcgcttgg
     6061 cggccagtga gccgatgccc atggcgaaga ccatgaggga cagcacgatg gaggtgtggg
     6121 tgacggtgtc gcccaccagg tagtcggcga gcgcgatgag ttcgagttcg tacacgaggc
     6181 cgcaggcggc gcagacgaag acggcgacga ggaccacgag gcgcccggcg cccgccgata
     6241 cggggagcac ggcggtcgct gagcgcgggg cggccgcctg cccggttgta tcgatcatga
     6301 accgaacgtt acgtcacact tcgggttggc cttgtcaccc acaggagtgg acttggggtg
     6361 atccgtcgca ccgctcaccc gggttctcgt cgccaccaga caccgctcct gcgggtacgc
     6421 gtgccaggtc cgccagtgga actgaccgcc cctgcgctgg accagaagcg cggtgaacgc
     6481 gttcggatca ccgggaaaga ggcccgcgag gccgtacggg tgttcggcga ccagggcaag
     6541 caactcctgg gcgcggcccg cgaacgagcc cacgctcagg ctctccacgc gggccgcgaa
     6601 ctcgtattcg aagtttccca ggcgcttgga cacaccgagc ggcaacgggg tgttgctgcc
     6661 cggcatgcag gccacggttt ctgagcaggt gccctcgcgg cagtcgagca gcacctgatg
     6721 ggaggcgccg agcacgcgca actggatgtg tgccccggca agttcgacgt cgagagtggc
     6781 gagcgagggc agcggctccc ggccgagggc ccaggccagg tcgcccgctc gggtgtcggt
     6841 gaaggcggtg tagatcgtgg tgagcatggg tcggctcccg catgcgcgca gttgagggcg
     6901 gcgcggaccg accctccgga gacaacggga ccaccgaatc acgtaacacg ccgccaccac
     6961 agcgttttta cccaacttag ccaggtttcc atcccgtcgg ggacagggtg gtcaggtgtt
     7021 caccccgcac ccgcccgcca tacgaacagt tgagccaggc cgtccgcgaa ctgctcgtat
     7081 cgtccccgcg gttgattcac acatcacacg gaacgccgac ttcgcgcccc cctcctccac
     7141 atctcgaccg caccccgccc gccgcggcgc gcgcccccgc ccccggaccg ccggcggctc
     7201 agcaggtggg cagcggcaga tggctgagga tcgcctgctg catgccccgc agttgaggcc
     7261 cgggaaacag gccgtggtcc accagccgcc ggttcgcctg ctggtagacg gccagggccg
     7321 cgctgctgtc gcccgcgccg tgcagcgccc gcatcagcag ctggtacgcc gcctcatcgg
     7381 tcgggctgcc caccaggtgc tgccgcagaa cgtcctgcgc cctggcgtac tgcccggctt
     7441 ccagggacag ttcggcgacc tggagcagcg cgcgccgccg gtggccgttc atccgctcca
     7501 cccagctctc cagcagcgga ccgtgctcga tgccgctgag cgccggcccg cgccacaggc
     7561 cgagggcgcc ctccagcagc tcccggcgct gccgcgggca ggccgtcacc tcggcccggt
     7621 cgacgagccc gcggaactcc tcggcgtcca cgcgcgcttg cggcagggcc agttcgtagg
     7681 cgccgagccc ggtccgcacc gcggcggccc cgacctcgcg gcgcagcagc ccgatgtagc
     7741 cgcggatatt ggcgaccgcg gagtctggcg gccggccccg ccacagttcc gcgccgatcc
     7801 gttccagcgt gacgggcccc tccgcgacga gcaggagcgc gagcagcgcc cggggcttgg
     7861 gccacatggg ccgcggcagg gcgccttccc tgatgaaggt gaagggcccg agcagccgga
     7921 atgcgtgcgc cctggtgccg gggagcgcag tgggcgtgga cacctgaatc ccccgttccg
     7981 aagtctccga acatgcaacg gggttcagcc tgccgcccgc ggctgagcga aagcttgacg
     8041 gaagctgacc gccgccgttc agcgcggatt caggcgccgg gcgcgctccc ccggccgccg
     8101 aacgggtgcg ggtgcgggtt cacgtccgcg ggcggcagcg ggctggtgcg gtgcccgagc
     8161 cgcaccggca cctcggcgag gcgcggcagc cggtccatgc gccggcgcgc gtgcccgtag
     8221 gtcagcggca ccgtaccggg caccagcacg ttcacgcagg ccaggccgcc cgcggcgtgc
     8281 tcagccgcgg tctggtcgac caccacgacg tccataccgc ccgcggtgta gcggccgacg
     8341 gcctcgagca ggtggccgag caggtcgtcc ccggcgaacc caccgcgctc cgcgccgatg
     8401 tcgaccggct tgcggctggg cgccgcgctg gtgaggaagc gcagcctggc cgcggcgccc
     8461 gggtcgccgt acagcagcgc gtgctgttcg gccgtccgca ccagctcggg cgcctcggcc
     8521 atgcggcggg ccagctccgc cgcgcccgcc tccgcgtagc cgtcgagcag ggcggcgagt
     8581 gccgggccga ggtcgtgcag cgcgcggcgg atcgccttct ccgggtcggg gtgggcgccc
     8641 ccggcgcacg ccacggcggg cccgccgttc cccgcggggt tctcggccag cgcccacacg
     8701 caggggatgc cctgctccgc cgagacgtcg aacgcccgga cgcggtagcc cgtttcggcg
     8761 cgaacggtgg cggcgagcag cggaacggcg cggtcggccg ccgccgccag gtctatctcg
     8821 gcggcggcga gcctggcgta ccacgtcatc agcagcgcgt cccgccgggc gacctggagc
     8881 aggccgtgga ggatcgcctc ctccaggctg ccgcccaccg cgctgccgcc gggcccctcg
     8941 gcctgcccgc ccgcggccgg gtcgcggtag gccagggact gcggcaccag cacgctctcg
     9001 cgcctggcga acgaccagcc ccacacccag gcgagcgggc ggtcctgaca cggctccggc
     9061 gcgaacgggt cggcggcgcg cgggtcgagg gcccggtcgc ccagctcccg gaaggtggcc
     9121 gtgacggcgg cggaccgccc gccgggcgcg ttcccgtacc gttcgacggc gccgagcagg
     9181 gccgacagcc ggctggtgcg ggccgtcggc gcgtgaccgc ggcccgcggt cacgcggccg
     9241 gtgcggaagc cgaccggggc ggacgtcacg accaggccgc cgacccggtg gccgtcgagg
     9301 gaggcgatga ggccgacctg gtcgtcgacg taggcgtcgg tcagctcgca cagggcgtcg
     9361 cgcagcggcc gggcgcggaa gcggccagga cggtgggccg accgggccgt gagggcgggg
     9421 acggcgcctt ccgcggtgtc cgcgggcacg tcgccgcaca cctcgcacag cggctcgggc
     9481 aggaaggggt gccgggtgac ggacagatcg tccagcgcga cgcgcagcag cgccttgcgg
     9541 gtgcggggcg cgcccggctc ggcgcccgac aggcgttccg cctcctcggc gacgagcccg
     9601 gcgacgagcc cggccgcggt gcccgtcagc cacgaggggg cggtggccgc gagcgcgcgg
     9661 ccgtgccgcc gccggacggc gtcgcgttcg tcctggtccg ggcggatgcg gcgggcgcgg
     9721 gccgtggcgc agtcggcgca gccggtgccg ccggggactt cgagcgggcc tacgacggcg
     9781 tggctcagct cggtgcgcac cggcagccag ccgatgccgt ggtcggcggc ggtgcgccgc
     9841 gccgtgtcgt gcagggccgt gtcccagccc tcgtgcacgg ccacgagcag cgtgcgcggc
     9901 cccgcggtgc cgccgcttct ggcgaggacg gcgtcgtaca gcgcgccgcc ggagccgagc
     9961 acacagattc tggcgcgggt gggcatggcc tcggggctgg tcacagcacc accacgtgaa
    10021 cgagataggg catcagttcc gcgaccgcgg ggtcgtggtc gagcggcacc gcgaccgcgg
    10081 tgtggccgag ggcgtcgagc cgcgccgcca ccgcggcgac gtcgagcggc gggttgacgg
    10141 ccggggtgtg cgcgtcccgc gagcgcagcg cgtggggcag cccaggcacg acggggaacg
    10201 gcgcgtatcc ggtctggagg tgggcgcgcg cctgcacgcc gagcagcacc tggcgcagcc
    10261 cgtcggtcag ggcggcggcg gcggtgagcc cggcggcgca ggcgacggtg acgggcccgc
    10321 ggcagaacgc gtaggtgggc acgccgagtt gcccggtgac gtcgtaggtc tccggcagtt
    10381 cgtccagctc ggcgaggatg tcccggcagc gggcgccctc ccggccgagc ggcgcctcgt
    10441 cgagcggcac acgcgggtag ggccgcgtgg tctcccgcat ccgtaccagt gtcagcaggc
    10501 ggcagtgcgc gaggagtccc gcggtgacgg cctcctgcca gtcctggccg ccgacgacgg
    10561 gcgagaacgg gtcgtccgag gggcgccagg gccgcagccc ggggaacgcg tccgccaccg
    10621 gtacgcggtg gacgcggccc gggtcggcca gttcgtagcc gagcaccgcg ggcccctgcg
    10681 gctcgtcggg ccccgcggcg ccggccccgt gctccccgtt gccgccgtcg gcgtgccccg
    10741 gcagtctccg cgcgtcgaac tggcctgcgg cgtaccgggc cagggcggaa agcgcggcct
    10801 ggtggcgggc ctggagttcg ccgaagccga agccgatggc gctcagttgc gggcgccgcg
    10861 tcaccacggc gcgggcgacg tgcagcgggg actgcgccca gtcggtgtcg acgaagcgga
    10921 agatgccgag ccggtcgtcg gcacagctcg cggcccgctg cgcgaacgcc tgcccgctca
    10981 gccgcgggcc gcggcgcagc gcgcggatgc gttcggcgaa gcggggccgg tcgggcgccg
    11041 gggcgggcag cgcgacgggg tgcggcagga acggccggcg ccgcccggcg agcgtggcga
    11101 ggtcgatggt gatcaactcg ctccggtccg gggccggttc ggcgccggtg acgacgtgga
    11161 acacgctctg gacgaggcgg gcggccacgg cgagacgggc ggcgggtcca ggggcggcgg
    11221 tcaccgtctc ggcgggcgcg gcgagccggg gcagcgcggc ggcccagcgg ccgggcgcgc
    11281 cgccggttcc cgtccagcgc tggaggggga tcagccacgc ctcgggcccg cgcacgacgg
    11341 cctgggcgag cggcaccccg gtgcgcgcgg cgcaccgttc gaccagcagg gcgcggtcgg
    11401 cggggcggct ggtgacgtgc agcaccaggt cggcgcggtc gagcagcgcc gtcatcgcct
    11461 cggcgtcgcg cggctcggga tgccgttccc acgtcagccg ctggcccgag tcccgcggcc
    11521 gcggccgcgg cccgcccccg tcgtcgaacg cgacgacgcg cacggtgcgc aggccggagg
    11581 cgacggcggc gcccgcgacg gcctcgagca gcggcccctc gccggcgacc agcgtgcgct
    11641 gggcgcggtg gcggacgaac gcggcggtgg cgtcgtcctc ggtgaacccg gtgatgtgcg
    11701 cgatctcctg ggcgtactcc tcggcctcgg ccgcggtcag ctccgcgtgc cgcgtgggcg
    11761 cggcgtcgcg cacgacgccg gcggcgcgca gccgccgcag catccgttcg acgaactcct
    11821 gctggtcggg cggcagtcct tcggtcagct ccgcgacggt cctgctgccg tcgaggctcg
    11881 gaagcaaacg gtcgagccag gggcccacgg cctcgcccgc gagccggacg gctcccctcg
    11941 gggtgagcag gtacgcgccg tcgccggtgg cggcgtggta gacgtcgtgt cgcacgatcg
    12001 gcttcatgac ggggctccct cgtcccacgc ggccttcgca gtggtgtgca tcatctgaca
    12061 gagaactcca acgtccttga gtaccgctct ggtcccgacg gacgacgctg ccctacggac
    12121 gcccgggcga cacccccctt tttcaagatc cgtcacgtgc ggcgtgatct gcgtactgcc
    12181 tgcacgagat cgactccttc tggccgagcg gcgaagaaac ccgaccgcaa gcatcggcga
    12241 acaggcttgt cggatacctt gacaggttct gaaacggcgc ttcagccacc cccgcgccgt
    12301 tgcttccgca cgcgcgtccc cgacggtata cagccgggaa cctcccgggg gatgcgcgcg
    12361 ccggcacgcc ggaacgcgcc gagggatggg gacggatgac gcatggttga gataaggctg
    12421 ctcggctccg tggagctcag ggcggcgaac ggcgcccggc tggacccggg ccctccgcag
    12481 cagcggtgcg tactggccgt actggccatg tcgcccggcc gggcggtgac cgctgagacc
    12541 ctgatcgacc gggtctggcc gcgccagccg ccggaaaacg tccgcgacgt gctctacacc
    12601 tacatatccc ggctccgccg ggtgctgcgg cgcctggggg acggcgccgg gagccccgtg
    12661 ctgcgccggg gggacggggg atacctgctc gacgttccgc aggacgccgt cgacctgcac
    12721 cgggcgcgcc gcctggccgc gcaggccgcg cacgtcacgg gcgaccaggg cggcacggcc
    12781 ggcgcgggcg gcgcggacgc cgaacgcgcc gccgaactgc tggccgaagc cgccgcgtta
    12841 tggcgcggta caccgctgtc cgggctgcgc ggtgagtggg cggagggcgt caggggcggc
    12901 ctcgaacgcg agctggtcac cctgctcacg gaccggttcg cgcaggaact gcggctcgcc
    12961 cggcacgccg acgtggtgcc cgccctgtcg gcggccgtgc tcgaccaccc gctggcggag
    13021 ccgctcgcgg aacagctgat gctggcgctg taccgctccg ggcggcaggc ggacgccctc
    13081 gccgcctaca ccaggaccag acagcggctc gccgccgagc tgggcgcgga gccgggcgcc
    13141 gcgctgcggc ggctgcacca gcgcatcctg cgccgcgacc ccggtctcgg ggcccgggcg
    13201 gcggccacgg acgcgcggcc cagtcaactc ccgccggacg tcacgtcgtt caccggccgc
    13261 gcggcggaga tccgcgagct cgacgggctg ctcccgcgcg agggcgaggg cggcaggagc
    13321 gccgcggtga tcgtcaccgt caacggcagc gcgggcatcg gcaagacgac gctcgcggtc
    13381 cactgggccc accgcgtcgc cgcgcacttc ccggacggcc ggctctacgt cgacctgcgg
    13441 gggctcggcg cgaccgggga gccgctcgac gcctcggacg cgctgcgcgg catcctctcc
    13501 gcgctccggg tgccgccgca gcgcgtcccg gccgatctgg acagccaggc cgcgctctac
    13561 cgcagcctgc tggcggggaa gcggatgctc gtcgtgctgg acaacgccag ggacaccgcg
    13621 cagtgccgcc cgctgctgcc cggatcgccc ggcagcctgg ccgtcgtcac gagccgcaac
    13681 cggctgctcg gcctggtcgc ctcgctcggc gcgcgggcgg tcaacctgga cctgttcacc
    13741 cgggacgagg cgtggcagat gctcgccgac cggctcggcc cgcggcggct cgccgccgac
    13801 gcgcgggccg tggacggcat catcgacacg tgtgcgcggc tgccgctcgc cctggccgtg
    13861 gtcgcggcgc aggccgccgc cgcccccgag cgcccgctcg ccgaactggc cgacggcctc
    13921 cgcggtcccg agcccctgaa cgcactcgcg ggggaggcgg gggaagcggc cgaggaggcc
    13981 ggggcggccg gggcggccac ggacatcagg gcgctgttct cctggtccta ccgggcgctg
    14041 agcccggcag cggcccgcct gttccggctc ggcgggctgc atccgggccc cgacctgacg
    14101 ccggtctcgg ccgccgcgct gaccgggctc ccgccgcgtt ccgcgcgggc acagctggcc
    14161 gagctgagcc gcgcgcagct gctgaccgaa cgcgaaccgg gccggtacgc catgcacgac
    14221 ctgctgcggg cctacgcgcg cgagctgacg gcggccaccg acgacgcggc ggaacggcgc
    14281 gccgcgacgc ggcgggtgct ggactactac ctgcactcgg cgcaccgcgc ccaccagcag
    14341 ctcggcccct cctggcggca gcccaccgac ctcggcacac cgcgggacgg catcgccgtc
    14401 gagacgttcg cggacgaggc cgcggcggtg gcctggttca ctgcggaacg ggcctgcctg
    14461 ctggacgcgt tcgaaggggc ggcggccgag gagttcgaca cgctggtctg cgcgctggcg
    14521 tgggtcctga ccggcctcct cgaccggcaa ggccactggc acgacctggc ccgcgtccag
    14581 gacaccgcct tcgacgcgtc cctgcgcctg ggcgaactcg gcgagcaggc ccgcgcgttg
    14641 aacaacaagg cgcggctgag caccaggttc ctgcactacg acgaggcgct gagcctgctg
    14701 cgggacgccc ttgacctgct ggaggcgatc gacgaccggc aggggcaggc ggagacgcat
    14761 cagcatctcg gcttcgtgct ggagaaccgc ggacggctgc ccgaggcgct cggccacgag
    14821 cgccgcgcgc tcgcgctgta ccgcgcggcg ggcaacaggc cggacgaggc acgttcgctg
    14881 aacgtcgtcg gctggctgct ggcccgcctg ggcgagcacc gggaggcgct ggactactgc
    14941 cgccaggcgc tccggctcca gcaggagggg gacgacgcgc tcggcctcgc cgcgacgctg
    15001 gactccctcg gctacgtcca gcaccacctc ggcgcgtggc cggacgccct gcgcgcctac
    15061 gagcgggccc tgtccctgct gcgcggcccc gggctcgggg accgttccct tgaggccgcg
    15121 ctgctccagc ggctcggcga cacgcaccgc gcgctcggga acgacgcggc ggcgggcgag
    15181 gcgtggaccg acgcgctccg catcatggag gagctcggca gcccggacgt ggcggaggtg
    15241 ctgacccggc tgcgcgatct gggcgtgggc cccgaacggc tgcgggccta cccctcctcg
    15301 cggccgccgg gctgatcggg cgcggcaagc agctgttcga cccgctcgac cttgccggtg
    15361 aggccgtcgg tgacaccgct gcgcaggtcg gccttcagca cgaggctgac ccggcccgcg
    15421 cgggcggtga cggcctccac ggcctgcttc accacggcca tcacctcgtc ccactcgccc
    15481 tcgacactgg tgaacatcgc gtcggtccgg ttgggcagcc cgctctcccg gaccacgcgg
    15541 accgcctcgg cgacctcggc cccgacgttc tcaccggtgc cgatgggcgt cacggagaac
    15601 gcgacgatca cggcgcggtc cccgtgccct cgcccgtggg gcctccggcg gtcccggcgt
    15661 cccccgagtc cccggaagcc gcggggtccc cggcgccctc ggcgttcctg gcgtcctccg
    15721 tgggctcgtc gtcctcgtcc ttggccagcc cgaaccggtc gacgagccac ttgtcgaact
    15781 cgcccgcggc ccgcacccag ctgaccacgc tggccacgaa gtggtcgaag ccgaccccgg
    15841 cccccagcag cagctggaag tcgccgacga gccggaccgt gccgtcgtcg ctggtgtgcg
    15901 tgtagacctt gggccagagc gtcgagtggt tccactcgtc gatggcctgg agcagccgcg
    15961 gcttgtcgtc gacggtgtgc tgccggtcgt agaaggtgcg caccgtcagc acccgctgcc
    16021 gctcctcgcc gcggaacatg aagtacacgc ggtagtgctt ccacggcgcg agcagatcac
    16081 ccgacttatc cacggtgtgc ttcagcttca tacggtccag cagctgcttg accagctcct
    16141 ggttcggcat gatcggccct gtgggcctgc ccgcctgctg cggctggccc tgcttgtccg
    16201 gcttgcccgg cttacccccg aaattcggga tggcggacgg atcgacagac acaggtgagt
    16261 cccttcgtgc ggatggggaa gcctccccat cctctcccac acccgccccg gtctggcaac
    16321 cgcgggaacg gcgccgtccg gggcgggggc gggcgcgggc cgctactccc ggccgtccgc
    16381 cgttatcacc aggccgccgt ccagggccgc gtccacgcgg accgtatcgc cgtccctgac
    16441 ctcgccggcc aggatcttcc tggccagcgg gtccccgatc gcggtctgca ccagccgccg
    16501 cagcggccgg gcgccgtagg ccgggtcgtt cccctcgtcg gacagccagc gcagcgccgg
    16561 ctcggtgacc tccagggcca gccgccggtc cgcgagccgc cgctggagcg cgtcggtctg
    16621 gagccgcgcg atgcggctca gctccgggcc ggtgagcgcg gagaacacca ccaggtcgtc
    16681 gagccggttg aggaattcgg gccggaacgc ggtccgcacc gccgccagca cctcctcgcg
    16741 ctgctgctcc ggcttggtca gcgggtcgat caggtgctgg ctgccgaggt tggaggtgag
    16801 gacgaggatg gtgttgcgga agtcgaccgt gcggccctgc ccgtcggtca gccgcccgtc
    16861 gtcgagcacc tggagcagga tgtcgaagac ctcgtggtgc gccttctcca cctcgtccag
    16921 cagcaccacc gtgtacgggc ggcgccgcac ggcctcggtg agctggccgc cctcctcgta
    16981 gccgacgtag ccggggggcg cgccgaccag cctcgccacc gaatgcttct cgctgtactc
    17041 gctcatgtcg atgcggacca tcgcccgctc gtcgtcgaag aggaagtccg cgagcgcctt
    17101 ggccagctcg gtcttgccga cgccggtcgg gccgaggaag aggaacgagc cggtgggccg
    17161 gtccgggtcg gcgacgccgg cccggctgcg gcgcaccgcg tccgagaccg cccgcacggc
    17221 ctcgtgctgg ccgatcagcc ggcggccgag ctgctcctcc atgcgcagca gcttctccgt
    17281 ctcgccctcc agcagccgcc cggcggggat tccggtccag gcggacacca cgtcggcgat
    17341 gtcgtccggg ccgacctcct ccttgaccat cgtgtcccgc ttggcctccc gctcggcctc
    17401 cgaggcggcg gccagctccc gttcgagcgc ggggatctcc ccgtacagca gcttggaggc
    17461 ggcctcgaag tcgccgtcgc gctgcgcgcg ctcggccagg cccctggact cgtccaggcg
    17521 ctccttcagc tcgcccaccc ggttgagccc ctgcttctcc ttctcccagc gggcggtcag
    17581 gccgcgcagg tcctcctcgc ggtcggccag ctcgcgccgc agccgggcca gccgctcctg
    17641 ggaggaggcg tccgactcgt tggccagggc cagctcctcc atcttcagcc ggtcgaccga
    17701 acgctggagc tcgtcgatct ccaccggcga ggagtcgatc tccatgcgca gccgggacgc
    17761 cgcctcgtcg accaggtcga tggccttgtc gggcaggaac ctggaggtga tgtaacggtc
    17821 ggacagcgcc gcggcggcga ccagcgcgcc gtccgcgatc tgcaccttgt ggtgcgcctc
    17881 gtaccgcccc ttcaggccgc gcaggatggc gatggagtcc tccacgcccg gctcggcgac
    17941 cagcacctgc tggaagcggc gctccagcgc ggcgtccttc tcgatccgct cccggtactc
    18001 gtccagcgtc gtggcgccga ccatgcgcag ctcgccgcgc gccagcatcg gcttcagcat
    18061 gttgcccgcg tccatggcgg agtcgctgcc cgcgcccgcg ccgacgaccg tgtgcagctc
    18121 gtcgatgaac gtgacgatct gcccgtggct gtccttgatc tcgccgagca cggccttcag
    18181 ccgctcctcg aactcgccgc ggtacttcgc gcccgccacc atcgcgccca ggtcgagggc
    18241 gaccagccgc ttgttcttca aggactcggg gacgtcgccc ttgaccatcc gctgcgcgag
    18301 cccctcgacg acggcggtct tgccgacgcc gggctcgccg atgagcaccg ggttgttctt
    18361 ggtgcggcgg gagagcacct ggacgacgcg gcggatctcg tggtccctgc cgatgaccgg
    18421 gtcaagacgg ccctcgcggg ccgcggccgt gaagtcggtg ccgaaccgtt ccagcgcctt
    18481 gtaggtgccc tccgggtcgg ccgtcgtgac gcgctggccg ccgcggctgg cctcgaaggc
    18541 gtcgagcagc ttgcggtcgg ccgcgccctg ggcggccagc agctcggcgg tctgcccgcc
    18601 cttggcggcc aggccgatca gcaggtgctc ggtggagacg taggagtcgc ccagctcctt
    18661 ggcgcgctgc gcggcgtcgg cgacgacggc cagcagctcc cggttgggct ggggcttggc
    18721 cacggacgcg ccctgcacgc tgggcagccc ggtcagcagg cgctcggcac cggagcgcag
    18781 ggccgcctgg tcggcgtcga cggcgacgag caggtcctgg atgttctcgt tgtcctggcc
    18841 ggtcagcagg gcgagcagca gatgcgccgg ggtgatgtcc ggatgcccgc cggtcagcgc
    18901 gcggtcgttg gccgcgctga tcgcgtcccg gctcctgttg gtcagctcgg cgttcacttc
    18961 agcggtactc ctccgtaggt cccgtgtgcg tgcgcatgca tgagtctgcc agacgcaacg
    19021 tgcgataagt tgagtctatt ccactcaagc cggtttcggg gccgcaccgg gcacggaaga
    19081 cggcggagcg gcgggaccgc ggcgcctcgg ccgctcggcc gctcggccgc tcggccgttc
    19141 agccactcag ccgccgcccg ccgcggcgaa caggctccgc gccccctccg gatacggacg
    19201 gcccacgacg tgaccctgcc cgctgcccac cgacatcacg gccacgagcg tgccggaccc
    19261 ggtcgccggg tcgtagtccg tgagccacgg gccgccgctc gaccccgcgg tcaggtcgca
    19321 gccggacagc agcagtcccc ccagattcgg ctcctcggcc tcgcccgcgg tcagcacgtc
    19381 cgtctcgccc gcgcagtagt gcagcgtctc cccgtcgtag ggctcgaccg ccggatagcc
    19441 gaggacggcc acccgaccgc cctcggccac cggctcgaac gcgaggcggt tcgcgccgtg
    19501 cacctcctgg acggtgcgcc cgtcccggcg cccgagcgtg aggaacgcgt agtcgtgcgg
    19561 caggatcgcc gaggtctcgc gcgtcacgtc ccagccctcg ggcgtgtgga agccggtgac
    19621 gagccagccg tcctcgcggt aggtgtcgcg gccgtggtgg tagccgggca cgaaccacac
    19681 ctccttcgga ggctcgggac cggccgcggt gcgcacgcag tgcgcggccg tcgcgacgac
    19741 gctgccgttc ggcgcgtcga cgacggcccc cgagcagaga ccgagccgcc cgccgcccgc
    19801 gtcccacatc agcttgccga ccgtgccgac gggcccctcg gcccacggct gcgcggcggc
    19861 ggccgggcgg gcaccgaacg cgagcagcac ggcggcgagc gccacgggta tcggggaacg
    19921 cgcaattctc atgagcccac cctgtgttca cggaacggac atgtccagct accgtccgcc
    19981 gatcgagtgg ggtcgcggcc ggggttgacg acggccccgc ggcgtaaagt cccggcaaaa
    20041 cccggggact tcagcggtgt ggaccagtgc cgcaccgcag gcggcgacgg ggcgcgcgcg
    20101 aaagccgcgt ccgggcttcc tcccgcgcat tgacgccgcc gtccgcggcc atcaacatga
    20161 tcatgcccat ggcgacccag ccgtgccccg ggaggcccgc cttgcgacgc acccgtcccc
    20221 ccgtccgccg ttccgccgtg gccgccgcca ccgcgctggc cgccgccctg ccgctgctga
    20281 ccacggcggg accggccggc gccgactccg acgccacggg cctggcccgc gcgttcgccg
    20341 acgcggcgga acgtcacggc gtgcccgaga gcgtgctgct cggcgtctcc tacctcacct
    20401 cccggtggga cggccacgac ggcgcgccca gcgtctccgg cggctacggg ccgatgcacc
    20461 tcaccgacgc ggccacggcc ctcgccgcat ccgagccgac cggcgggcac cacgcgcacg
    20521 gcaccgagga cgcgcgcggc gacacctcgc ggccgctccc gccgccgtcc ccaggaccgc
    20581 gggacgcccc cgacacccgg gccgtcccgg cggacctccg caccctggcc gaggcggccg
    20641 agctgaccgg cctcgacccc gcggagctgc ggaccggcaa tgcggcgaac gtcaccggcg
    20701 gcgccgcgct gctggccgcc gcgcagcgcg acctcggcca ccccgcgagc ggcgaccccg
    20761 ccgactggta cggcgcggtc gcggcctacg cgggcgcggg cacccgcgag gccgcggagt
    20821 tcttcgcgga cgaggtgtac gccgtcatca acgagggcgc ctcccgcgtc accgactccg
    20881 gcgaccgcgt cacgctcccg ccgcgcgccg tcgtccccga cacccgcacc gccgacgcgc
    20941 tcggcctgcc cgccgccccg cgcgacccgc gcgtcgagtg cccgcgttcc gtctcctgcg
    21001 cgtggctgcc cgccccctac gaggagctgg ccggcggcgg ctacggcaac catgaccagg
    21061 cgcggcggcc cgcctcgcag tccgtcgact acatcgtcat ccacgacacc gaggccacct
    21121 gggagaccac cctcgacctc gtgcaggacc ccgagtacgt ctcctggcac tacagcctgc
    21181 gctcccggga cgggcacatc gcgcagcacg tcgcgggcga ggacgtcggc tggcacgcag
    21241 gcaactggta cgtcaacgcc aagtccatcg gactggagca cgagggcttc ctgaccgacc
    21301 ccgacgcctg gtacacggag gcgatgtacc gcacctccgc gcgcctggtc cgccacctgg
    21361 cgcgggagta cgacatcccg ctggaccgcc accacatcct cggccacgac aacgtccagg
    21421 gcccgaccga cgcgagcgtg cccggcatgc acaccgaccc ggggccctac tgggactggt
    21481 cgcactactt cgacctgctg ggcgccccgt tccgcgccac cgcgggcccg cgcggcggcc
    21541 tggtgaccat cgcgccggac tacgagacgc acaccccggc gtacgaggac tgcgagggcg
    21601 ccggctcccc ctgcgcgccg cacggttcgg ccgccgtccg cctgcacacc gcgcccgcgc
    21661 acgacgcgcc tctggtccga gaccccggca cgcaccccgg cgacggcgag tcctccaccg
    21721 gcgtgaacga cgtgggcgcc cgcgcctccg cgggccagca gttcgccgtc gccgaacgcc
    21781 gcggcgcgtg gacggcgatc tggtacctcg ggcagaaggc gtggttccac aacccggcgg
    21841 acgcgccgac cgcggtgaac gcccgcggct gggtggtcac cggcaaggac ggcgccgcga
    21901 ccatcccggt ctacggccgc gcctacccgg aggccggcgc ctacccggcg gacgtcccgg
    21961 tacagccggt cgtgccgctg tcgtacgaga taccggccga ccaggag
//
