LOCUS       NZ_CP019458            22092 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces autolyticus strain CGMCC0516 chromosome, complete
            genome.
ACCESSION   NZ_CP019458
VERSION     NZ_CP019458.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces autolyticus
  ORGANISM  Streptomyces autolyticus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10029028)
  AUTHORS   Yin,M., Jiang,M., Ren,Z., Dong,Y. and Lu,T.
  TITLE     The complete genome sequence of Streptomyces autolyticus CGMCC 0516,
            the producer of geldanamycin, autolytimycin, reblastatin and
            elaiophylin
  JOURNAL   J Biotechnol 252, 27-31 (2017)
   PUBMED   28472671
REFERENCE   2  (bases 1 to 10029028)
  AUTHORS   Yin,M., Jiang,M. and Lu,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2017) Yunnan University, Yunnan University, 2#
            Cuihu Beilu, Kunming, Yunnan 650091, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Analysis v. 2.3.0
            Genome Coverage                   :: 279x
            Sequencing Technology             :: Illumina; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 03:05:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,227
            CDSs (total)                      :: 8,141
            Genes (coding)                    :: 7,920
            CDSs (with protein)               :: 7,920
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 221
            CDSs (without protein)            :: 221
            Pseudo Genes (ambiguous residues) :: 0 of 221
            Pseudo Genes (frameshifted)       :: 74 of 221
            Pseudo Genes (incomplete)         :: 182 of 221
            Pseudo Genes (internal stop)      :: 9 of 221
            Pseudo Genes (multiple problems)  :: 42 of 221
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:31:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9395649
            Orig. end                         :: 9417741
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP019458.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22092
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="43"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22092
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22092
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12092](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12092
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    complement(139..158)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: medium, score: 24.8"
                     /tool="antismash"
     gene            complement(636..1238)
                     /locus_tag="BV401_RS38850"
                     /old_locus_tag="BV401_38925"
     CDS             complement(636..1238)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014054208.1"
                     /locus_tag="BV401_RS38850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_38925"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_079259925.1"
                     /transl_table=11
                     /translation="MSPRRSAAEAQATRGRILGRAAEIASEEGLDGITIGRLAEELEMS
                     KSGVHKHFGTKETLQISTLDKAFVDFWHRVVEPTLTEPPGLRRLRAVCANSVGYLEAPL
                     LPGGCLMTAALTEYDGRPGRVRDAVAEVWSRWREQLRADLTAAVENGELPAGFDIDQAL
                     FEIIAAGLALNAAMQLQHDRAAAGRARRAIERTLAQP"
     gene            1333..2115
                     /locus_tag="BV401_RS38855"
                     /old_locus_tag="BV401_38930"
     CDS             1333..2115
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011029963.1"
                     /locus_tag="BV401_RS38855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_38930"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_069860397.1"
                     /transl_table=11
                     /translation="MRVRRLGWAGVEIEAGGRRLVVDYVRDLSPLFTGWKPGEGLAEPS
                     GKATAALVTHLHRDHTDASALADALTPGAPVLRPAPGHGDDVDNVTTLPAERELALHRL
                     AAEVVDAWSTREIGPFRVTAVPSVDGLGDPQLNWVVQADGQRVFHGGDTMFHGYWWLIA
                     RRFSPFDAVFLPANGAVVDAPHLQPPSPLPAALDPRQAAAAAEILDARYAVPIHYEPEQ
                     PDKIAGYVEVSDPEKEFRTHAGRRAHVLAVGEWLDLAT"
     gene            complement(2288..3457)
                     /locus_tag="BV401_RS38860"
                     /old_locus_tag="BV401_38935"
     CDS             complement(2288..3457)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056893.1"
                     /locus_tag="BV401_RS38860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_38935"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_069860398.1"
                     /transl_table=11
                     /translation="MEAAEQTDPTEPPLPPLVDHHCHGVVRSELGSAAFEAFLTESDAP
                     AALGTTFFDSQLGFAVRRWCPPLLGLEPHCPPAHYLARRRELGAREVARRLLSATGISE
                     FLVDTGLPGNLTTPQELALAAGGTAHEIVRLEQLAERIADTSLTADDFLTGVADGIREA
                     ARTAAGFKSVAAYRYGLDFEPDPPGPGAVHTAAERWLARRGQGGTAAARVTDPVLLRHL
                     LWSAAYTGLPLQLHTGFGDPDLRLDRCDPLALTDFVRAVRPTGCTLILLHGYPYHRGAA
                     YLAAVFPHVYADVGLALSHTGARAGAVLGEMLELAPFGKVLFSTDAYGLPELYVVGARL
                     FREALTGLLTHWVAEGAWSRRDARRVAALLGADNARRVYGLGTPAPRAG"
     gene            complement(3461..4819)
                     /locus_tag="BV401_RS38865"
                     /old_locus_tag="BV401_38940"
     CDS             complement(3461..4819)
                     /EC_number="6.3.1.-"
                     /GO_function="GO:0004356 - glutamine synthetase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006542 - glutamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056894.1"
                     /locus_tag="BV401_RS38865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_38940"
                     /product="glutamine synthetase family protein"
                     /protein_id="WP_079259926.1"
                     /transl_table=11
                     /translation="MGTGDREQAYARARQEAERLTANGIQGIALTWVDNAGLTRVKSVP
                     TARLPQAARRGVGMSPVFDVYLVDDSMTTSRHVGGPDGDLRLLPDLERLTPLAAQPGWA
                     WAPVDRYDQEGRAHPVCQRLFARRMAERARERGLAVRMGFETEWVVTTGDPDQDPPHYP
                     TTGPAYGMARLVDLADYLADLLGALDAQHTEVHQLHPEYSPGQFEVSLAPTDPVAAADL
                     AVLVRETIRACSGRAGLNPMFGPVVDPGGVGNGAHLHLSLWQGDRNLCRDGDGPHAMTA
                     TAEAFLAGVLRELPALLAIGAPSPASYLRLEPSRWAGAYQCWGLENREAAVRFITGAPD
                     DPGAANAEIKSFDPAANPYLVAGAVIAAGLGGLDAGLSLPPPVSGDPAVEGRERRLPTS
                     LLTALEHFEDSTVLREALGDPLFESIAAVRRAEAALFEKSSPREIAIATRRRY"
     gene            complement(5090..6115)
                     /locus_tag="BV401_RS38870"
                     /old_locus_tag="BV401_38945"
     CDS             complement(5090..6115)
                     /GO_process="GO:0015891 - siderophore transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1033: iron
                     compound ABC transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056895.1"
                     /locus_tag="BV401_RS38870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_38945"
                     /product="iron-siderophore ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_079259927.1"
                     /transl_table=11
                     /translation="MGPLRLFPLLSAVLAATLVTGCGSSAPASSSASSGSSGSSGSSGS
                     SAVSKAPGSSAADGDFPRTVAHEQGSTPLKAAPKRIAAISTGQLDDLLTLGVVPVATTR
                     ADYAGLVPDYLRTAFPGQAEALGSMTDIGTRTSPNLEKLAAAKPDLILVNSTQGALYPS
                     LAAIAPTVVTKGRGVNWKKDLLTVADAVGRRERARTLLTRFEKDAADQGEKLGGEHTAL
                     SMVRFNPDRVRMFGKKSFTGTIADDMGLGRPESQRFDDISQDLSGERIPQMDGDWIFYS
                     VQGRPGKTDAATYLSNPLWKKLGAVRGGHIAKVDDDPWYLNAGPTAARVVLRDITEHLG
                     R"
     misc_feature    6132..6150
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 28.03"
                     /tool="antismash"
     gene            6288..7433
                     /locus_tag="BV401_RS38875"
                     /old_locus_tag="BV401_38950"
     CDS             6288..7433
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712692.1"
                     /locus_tag="BV401_RS38875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_38950"
                     /product="glycoside hydrolase family 88 protein"
                     /protein_id="WP_079259928.1"
                     /transl_table=11
                     /translation="MISRRTLFASTLGLTGGLLLPTAGAGAAPADWSRAVVDSTIARRP
                     DPASLGGWGYIQGLFLLGTYRVHQRVDEPSYLAYIKRWVDNFVDADGHMSRTFDNLDAM
                     QAGNLLLILHQETGDPRYRTAAGQIRARITTYPRTADGGMWHATGRTNELWGDGVFMAQ
                     PFLLRYGIAYGDQEYAYEEVTRNLSVYFRHLKAANGLIYHGYDADGDAPWKPDPTTGTS
                     AHFWARAIGWTAMTHVEVLELLPADHPRRAELIDNVRHLAKGFARYQDPATGRWFQVVD
                     KASEPGNWTETSASSMYTLMLHAALEHGWISGGGYTEAVRRGYEGVLRKVSVGSDGLTN
                     ITDISEGTNVGDLAYYLGRARNTNDLHGLGAFLLMNERLAH"
     misc_feature    6303..6318
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.49"
                     /tool="antismash"
     gene            complement(7496..8575)
                     /locus_tag="BV401_RS38880"
                     /old_locus_tag="BV401_38955"
     CDS             complement(7496..8575)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712691.1"
                     /locus_tag="BV401_RS38880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_38955"
                     /product="PQQ-dependent sugar dehydrogenase"
                     /protein_id="WP_079259929.1"
                     /transl_table=11
                     /translation="MKRYRNTAAAAAATALAAGLLIGTAGTGTAAPGRADSAPSDIKTV
                     SSGWTVPWGLSWLPDGSALITERDSFKLYKLTQSGTRTEVGTVPNVVTTDGEGGLLGIA
                     VSPNWNSDHTIYLMHTASEGNRIARMTYDGSSLDGYQTLVTGIKKNKYHNGGRLKFGPD
                     GYLYATTGEAQTPDLSQDKNSLNGKILRMATDGKPAPGNPFGTLVYSYGHRNPQGITWD
                     PQGRLWEAEFGDSKYDELNLIEAGKNYGWPICEGECSTAGMTGPKRQWPTGDASPSGVT
                     YADGGMYLAALRGERLWRIPVDGTNAGTPKAYYTSSYGRLRTVETVPGKNTLWLSTTNA
                     DSNGGEPDGADKVFQVELK"
     misc_feature    complement(8792..8808)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.36"
                     /tool="antismash"
     gene            8975..9118
                     /gene="pqqA"
                     /locus_tag="BV401_RS38885"
                     /old_locus_tag="BV401_38960"
     CDS             8975..9118
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_093467075.1"
                     /locus_tag="BV401_RS38885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_38960"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_069860403.1"
                     /transl_table=11
                     /translation="MNDTTPRTAPEAADRTRTDAGQTAWQTPDYVVVETALEVTAYSLN
                     AR"
     gene            9129..>9458
                     /locus_tag="BV401_RS38890"
                     /old_locus_tag="BV401_38965"
                     /pseudo=""
     CDS             9129..>9458
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056907.1"
                     /locus_tag="BV401_RS38890"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_38965"
                     /product="MBL fold metallo-hydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRVRVLGTAAGGGVPQWNCACPGCSGARAHPGWRRRHASLAVQAA
                     EGRWYLVNATPDLGDQVEDHPELHPGPEPRRTPLAGVILTDAELDHTLGIARLREADGI
                     EIVATA"
     gene            10001..10708
                     /gene="pqqC"
                     /locus_tag="BV401_RS38895"
                     /old_locus_tag="BV401_38970"
     CDS             10001..10708
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056908.1"
                     /locus_tag="BV401_RS38895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_38970"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_079259930.1"
                     /sec_met_domain="TIGR02111 (E-value: 5.8e-83, bitscore:
                     276.8, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPRTRLEERLRAVAQERYHDRHPFNVRMHAGELTPAELRRWIL
                     NRFHYQRHIPVKDALITAKFDTPRLRRMWLRRIQDHDGTTEGEGGIERWLRLGEAAGLH
                     RDRLLSAEEVVPGVRLAVDGYVNFCRLRGPLEAVAASLTELSAPGIMLTRIDAFERYYP
                     WIEREGLTYFRNRVDQGRRDSTEALDAVLTWARTPEDEDRAVAALAFKCDVLWSLLDAV
                     DHADTKDGPEEGT"
     gene            10705..10989
                     /gene="pqqD"
                     /locus_tag="BV401_RS38900"
                     /old_locus_tag="BV401_38975"
     CDS             10705..10989
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056909.1"
                     /locus_tag="BV401_RS38900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_38975"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_069860406.1"
                     /sec_met_domain="PqqD_RRE (E-value: 6.4e-19, bitscore:
                     66.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.3e-11, bitscore: 43.5,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAAGTPPAPAGWRPALAPAVSLRHDRVRDADLLVLPERVVVLRG
                     SAARILRLCDGDRDLEAIVAELESRFPGAPVADDVRAFLGRMRGEGWVR"
     aSDomain        10744..10983
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BV401_RS38900_PqqD_RRE.1"
                     /evalue="2.20E-21"
                     /identifier="RREFam006.1"
                     /label="BV401_RS38900"
                     /locus_tag="BV401_RS38900"
                     /protein_end="93"
                     /protein_start="13"
                     /score="66.4"
                     /tool="antismash"
                     /translation="RPALAPAVSLRHDRVRDADLLVLPERVVVLRGSAARILRLCDGDR
                     DLEAIVAELESRFPGAPVADDVRAFLGRMRGEGWV"
     gene            10986..12092
                     /gene="pqqE"
                     /locus_tag="BV401_RS38905"
                     /old_locus_tag="BV401_38980"
     CDS             10986..12092
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056910.1"
                     /locus_tag="BV401_RS38905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_38980"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_079259931.1"
                     /sec_met_domain="PF04055 (E-value: 1.1e-21, bitscore: 76.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 6.6e-06, bitscore: 25.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.4e-06, bitscore: 26.3,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 8.4e-08, bitscore:
                     31.4, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAAPRPWALLAELTHGCPLHCPYCSNPLELVRRSRELSTAEWAE
                     VMRQAGEFGVVHTHLSGGEPLLRGDLAEIVTAAESAGIYTQLVTSGVGLDGARLTALTA
                     AGLRSVQLSVQHADPAAADRIAGHRAFAAKERAAALVRAAGLPLGINVVLHRDNLDALD
                     ALIRRGVDWGADRIELANTQFYGWALRNRDALLPTRDQLARARETVQRWRDRLGGATDL
                     VWVVPDYFDGVAKPCMGGWGAVSLTVAPDGTALPCPAAASLPDLDPPNVRDHSLEWIWD
                     HSGAFNRYRGEGWMREPCRTCSRRAEDFGGCRCQAYALTGDATRTDPACALSPDHGVIR
                     ALTDAGHPAAAATPAPTGGYAYRKPGGG"
     gene            12183..13661
                     /locus_tag="BV401_RS38910"
                     /old_locus_tag="BV401_38985"
     CDS             12183..13661
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947291.1"
                     /locus_tag="BV401_RS38910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_38985"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_069860408.1"
                     /transl_table=11
                     /translation="MTVTDEGRAERATAEGPGIDPERLATCLSVLAELDRLPVDHPDAI
                     TVRRATSGIYRSVKQRRRQERRAAKTANDKAVTEATATGAADRIDDETLGLALTSSVST
                     EIAGILARPRSCYVCKTRYVEVDAFYHQLCRDCAAENRARRDARTDLTGRRALLTGGRA
                     KIGMYIALRLLRDGAHTTVTTRFPGDAVRRFKAMPDSAEWLHRLKVVGIDLRDPAQVIA
                     LTDEVSAAGPLDILINNAAQTVRRTPQAYAELIAGESAPPPAGELPESLVLGAFGSGAQ
                     AALPGPRAARDGALTPQDLTALALTSGSASPARIEAGTAIDAGGLVPDLDPTNTWVQRV
                     DEVDPVELLEVQLCNETAPFILVSRLRPAMAASPARRKYVVNVSAMEGKFGRGYKGAGH
                     PHTNMAKAALNMLTRTSAREMFEADSILMTSVDTGWITDERPHPEKIRLAAEGFHAPLD
                     LVDGAARVYDPIVRGEAGEDLFGCFLKDYAPTSW"
     gene            complement(13640..13816)
                     /locus_tag="BV401_RS43230"
                     /old_locus_tag="BV401_38990"
     CDS             complement(13640..13816)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BV401_RS43230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BV401_38990"
                     /product="hypothetical protein"
                     /protein_id="WP_237288122.1"
                     /transl_table=11
                     /translation="MDGAPAERGARQDAGEYPDTGAYADVGADADTGAHPDVPAYQGVP
                     AHQDVRAYQDVGA"
     gene            complement(13851..15116)
                     /locus_tag="BV401_RS38915"
                     /old_locus_tag="BV401_38995"
     CDS             complement(13851..15116)
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056912.1"
                     /locus_tag="BV401_RS38915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_38995"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_079259932.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2.7e-37,
                     bitscore: 126.9, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIAFLLHNAYGIGGTIRTTMNLATALADRHEVEIVSMMRHRETP
                     RFALDPRVRLVPLVDTRPNGADAKDPLFFEASRDFPAAEKRHHQYNRLIDTRAAEYLRD
                     CPADVIVGTRPGVNVYISRFAPRRALRIAQEHLRYEAHSKKLRAELAPYYRSLDAVVTT
                     TEADAAVYREKMPMPGVLTLAIPNSVPEPAVAPSEGTAPVIAAAGRLVRGKRFDLLIDA
                     FAEVSEKYPDWRLRIYGGGAEKERLAEHIERLGLSGSAELMGSYSPIEAEFAKASLVAV
                     ASDAESFGMTIVEAMRCGVPVVSTDCPLGPAEIIRDGVTGRLVPTGDKHALASALMELM
                     ADAPARRAMGAAALEGSRIYDPAPIARRYDQLFEELRTSRFARGWERYRTAARARWRRL
                     ARRFGIAPGRRRTPAAGEKASA"
     misc_feature    complement(15206..15221)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.35"
                     /tool="antismash"
     gene            15292..15996
                     /locus_tag="BV401_RS38920"
                     /old_locus_tag="BV401_39000"
     CDS             15292..15996
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056913.1"
                     /locus_tag="BV401_RS38920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_39000"
                     /product="response regulator transcription factor"
                     /protein_id="WP_079259933.1"
                     /transl_table=11
                     /translation="MTNTVLLAEDDRAIRQALERALTLEGYRVTGVPDGIEALAAIHRE
                     RPDVVVLDVMMPGVDGLQVCRVLRAEGDRTPILMLTARVETADRIEGLDAGADDYVAKP
                     FEVEEVFARLRALLRRAAPAEPAAPEDTAIDGVLEVSDLRLDSSARRVWRGGTELELTR
                     TEFDLLELLARNAGIVLDHATIYARIWGYDFGPGSKNLAVYIGYLRRKVDPEGRTPLIH
                     TVRGVGYTLREE"
     gene            15996..17420
                     /locus_tag="BV401_RS38925"
                     /old_locus_tag="BV401_39005"
     CDS             15996..17420
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056914.1"
                     /locus_tag="BV401_RS38925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_39005"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_079259934.1"
                     /transl_table=11
                     /translation="MVRLPRLRRRRPSLRTTFALSFSAAATVVTLLVGGLSYDAAAGLV
                     RVDQQSAFDDVIHDLRGQVRGDKVVLRQYPTESTGPVPYDLRDDLRRISRMDVQVINGR
                     GTVYDAGKPPLPVTDEDRTTAAAHTAGTVVRREIDIGGEQYRMATVAVGDGTGAVQVAQ
                     QISDTEDLLQELQQRTALFVVAVILAAGLAGWWLAGRITRRLVRLTRVAESVAATGRME
                     VAVPVAGDDEVGRLGRAFDGMLGQLARSKDDQRRLVQDAGHELRTPLTSLRTNISLLRR
                     FEDLPGPAREDLLADLAGETRELTDLVNELVDLAAGQRDDEPRTEVLLEEVATTAVTLA
                     RRRTGREITVRASGDTRLTGHPATLQRAISNLVENAAKFDQDGTEPVEVMISGRRVEVL
                     DRGPGIAAEDRERVFDRFYRAPGARSLPGSGLGLAIVREVALAHGGTVFARPRPGGGAI
                     LGFTVGDGTGSIGTGP"
     gene            complement(17445..18263)
                     /locus_tag="BV401_RS38930"
                     /old_locus_tag="BV401_39010"
     CDS             complement(17445..18263)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056915.1"
                     /locus_tag="BV401_RS38930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_39010"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_079259935.1"
                     /transl_table=11
                     /translation="MTDYGLAPDQIDTTKPHPARMYDFYLNGKDHYEVDAEAAGRVLEV
                     YPTVRLNATVNRGFIHRATRWLAREAGVRQFLDIGTGIPTEPNLHQVAQGVIPEARVVY
                     TDYDPIVLAYAQALLIGTPEGRTAYVQSDVRDPERIMSAPELHETLDLTQPVAISVNAL
                     FHFIPEEDKPYEIVRKLMEPLVPGSYLMLTHSTHDFSEETWRNVIQVYKESGISFTTRS
                     QSEVGAFFDGLELIDPGVSEPHQWKPDPGDRPEAIRSADINMWAGVARKS"
     gene            complement(18260..18556)
                     /locus_tag="BV401_RS38935"
                     /old_locus_tag="BV401_39015"
     CDS             complement(18260..18556)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018542876.1"
                     /locus_tag="BV401_RS38935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_39015"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_069860413.1"
                     /transl_table=11
                     /translation="MDQVDVYNGMPAKQLAIEGWAKPWSGPNGGACVEALRLKDGRVAL
                     RQSTDPDGPALIYTHHEIERFIQGAKAGAADFLLTRPENLTTSAGSAPERRAA"
     gene            complement(18559..19416)
                     /locus_tag="BV401_RS38940"
                     /old_locus_tag="BV401_39020"
     CDS             complement(18559..19416)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712676.1"
                     /locus_tag="BV401_RS38940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_39020"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_069860414.1"
                     /transl_table=11
                     /translation="MGEARSAPTVGQMVLGMRLRDLREKAGVNYDQAARALHVNQTTVR
                     RMEKAEVGLKLPYVEKLLQTYGADQEEIDSFLALAEEANRPGWWHRFRDVLPDWFSLYV
                     SLEGAASRIRAYEPHFVPGLLQTEDYARTLLSIGFPHGSDRELERRVALRMERQELLHR
                     PNGPHLWVVMDETVLRLAIGGPEVMRAQVDHLIEAAQRPNVTLQVVPFSAGPHPGMGGP
                     FQLFRFQIPELPDIVYAEGLTGAGYLDQRSDVVAYLEALDRMGTQATPARRTESFLRGI
                     RKEL"
     misc_feature    19495..19507
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.63"
                     /tool="antismash"
     gene            19642..20109
                     /locus_tag="BV401_RS38945"
                     /old_locus_tag="BV401_39025"
     CDS             19642..20109
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056918.1"
                     /locus_tag="BV401_RS38945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_39025"
                     /product="ATP-binding protein"
                     /protein_id="WP_069860415.1"
                     /transl_table=11
                     /translation="MAVALRQRSTMAHHPSPGSVDSALRQERFQLPARGASVAIARHRV
                     RSRVPEWGFHEDLCDAAELVMSELFTNALVHTGSEQILCVLRAHERRMLYVEVADQGGG
                     PAVPTPREAGLEDECGRGLALVRALADAWGDRPGVDGGRVVWAQMSVAVGR"
     gene            complement(20134..21426)
                     /locus_tag="BV401_RS38950"
                     /old_locus_tag="BV401_39030"
     CDS             complement(20134..21426)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1074: major
                     facilitator family transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056919.1"
                     /locus_tag="BV401_RS38950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_39030"
                     /product="MFS transporter"
                     /protein_id="WP_237288124.1"
                     /transl_table=11
                     /translation="MFGGSIGNLVEWYDWFVYASFATYFAGAFFPKGNDTAQLLNTAGI
                     FAVGFFMRPVGGWLLGRFADRRGRKAALTLTVSLMSASALLIAIAPTYDQVGYFGAGVL
                     LVARLLQGLSVGGEYAASATYLTEASRPGGRGFVSSFQYVSMTMGQLMGLGLQIVLQHT
                     MSDDALHSYGWRIPFIVGAVGAAVVFWLRRNLLETEIYAEEDARQDQERGTIAELLRHR
                     KEAALVIALTMGGTVAYYTYTTYLTKYLSNTAGMSKSDASLVSFCALFLFMLLQPLAGA
                     LSDRIGRRPLLITFGFGSMLGTVPIMTALSHADTFTGALLLSLAALVIVTGYTSINAVV
                     KAELFPTHVRALGVALPYALANALFGGTAEYVALWFKKGGVESGYYWYVSACAAVSLVV
                     YLTMRETRDAALSRDRADGPAAPGKQRTTAV"
     misc_feature    21531..21542
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.39"
                     /tool="antismash"
     gene            complement(21629..21964)
                     /locus_tag="BV401_RS38955"
                     /old_locus_tag="BV401_39035"
     CDS             complement(21629..21964)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056920.1"
                     /locus_tag="BV401_RS38955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_39035"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_079259937.1"
                     /transl_table=11
                     /translation="MEKQPYVCGLDAAVDVIDGKWKVLIIWALNHQRCRFGELKRLVPG
                     VSEKVLTQQLRELAADGIVHRESYDVVPPKVEYSLTGLGEELNTALRPLGAWGKRRMAT
                     LAETGRG"
ORIGIN
        1 gccgggggag gccgtacggc ccgacagcga gccgatcatc accagatgac cggaccccga
       61 ctccaccatg tgcggcgcca tcagccggga cagcagcatc ggggcgcgca gattgacgtc
      121 gagggcgcgg tccagctcct cgggccggta gtccaggacc gggccgctgg agggcagcgc
      181 ggcgttggcg atgaggatcc gggcgtccga cgcctcctcg acgaggcgct ccacatcgga
      241 ccgttcggcc agatcggcga cgatcgcccg gccgccgagc tggtccgcca gcgggcgcag
      301 cacctcctcg cggcgcccgg tgagcagcag cttggcgccc ttggccgcga gcgcgtgggc
      361 cagtgtccgc ccgatgccgc cggtggcccc ggtgagcagg acggtcgtgc cgccgatccg
      421 catgcgatct cctccggtta cggtcgagta cgttccgggc acggtactgc ggacgcgctc
      481 cgcgccgggc atggaccctg gtccgccacc gacgcgcgcg gcgcctcggc ccggacgtcc
      541 cccgtgtccg gcatcggccg ccccgcgtcg gcggccgtct ccggcgcgca cggcggcggc
      601 ctgtcggctg ccgggccggg cgggggcggg tcgcgtcagg gctgggccag ggtccgttcg
      661 atcgcgcggc gggcccggcc cgcggcggcc cggtcgtgct ggagctgcat ggccgcgttc
      721 agcgccagac cggcggcgat gatctcgaac agcgcctggt cgatgtcgaa tccggcgggc
      781 agttcgccgt tctccaccgc ggcggtcaga tccgcccgca gctgttcccg ccagcgcgac
      841 cacacctcgg ccaccgcgtc gcggacccgg cccgggcggc cgtcgtattc ggtgagtgcc
      901 gcggtcatca ggcagccgcc gggcagcagc ggcgcctcca ggtagcccac ggagttggcg
      961 cacaccgcgc gcagccgccg caggcccggc ggctcggtca gggtgggctc gaccacccgg
     1021 tgccagaagt ccacgaacgc cttgtccagt gtggagatct ggagcgtctc cttggtgccg
     1081 aagtgcttgt gcaccccgga cttgctcatc tccagttcct cggcgagccg gccgatggtg
     1141 atgccgtcca gcccttcttc ggaggcgatc tcggcggcgc ggccgaggat ccggcccctg
     1201 gtggcctgcg cttcggccgc tgagcgtcgt ggtgacatac ggcaaggata gcgtacgtgc
     1261 gttcgctatt gatttagcga acgtgcgtac gctaagttcc gcatggcaat caccggaacg
     1321 aaggagtgcg agatgcgggt gcgacgactg ggctgggccg gagtggagat cgaggcgggc
     1381 ggcaggcgac tggtggtcga ctacgtccgg gatctctcac cgctgttcac ggggtggaag
     1441 cccggtgagg ggctggcgga gccgagcggg aaggccaccg ccgcactggt cacccacctg
     1501 caccgggacc acaccgacgc gtccgcgctc gcggacgcgc tgacgccggg ggcgccggtg
     1561 ctgcgaccgg cgcccggcca cggcgacgac gtggacaacg tgacgacgct gccggccgag
     1621 cgcgaactgg ccctgcaccg gctggccgcc gaggtcgtgg atgcctggtc cacccgcgaa
     1681 atcgggccgt tccgcgtcac cgcggtgccc tccgtcgacg ggctcggcga cccgcagctg
     1741 aactgggtgg tgcaggccga cgggcagcgg gtcttccacg gcggcgacac gatgttccac
     1801 ggctactggt ggctcatcgc gcgccggttc agcccgttcg acgcggtgtt cctgcccgcc
     1861 aacggcgcgg tggtcgacgc accgcacctt cagccgccga gcccgctgcc cgccgcgttg
     1921 gacccgcggc aggccgcagc ggccgcggag atcctcgacg cccggtacgc ggtgccgatc
     1981 cactacgagc cggagcagcc ggacaagatc gcgggctatg tcgaggtctc cgacccggag
     2041 aaggagttcc gcacgcacgc cggacggcgc gcacatgtgc tggccgtcgg ggaatggctg
     2101 gacctggcca cctgaccgga aactccgccg tgccaacggg ctcgggcggc aacggccgcc
     2161 tcatccggca tgaaccccgg ccgcggcgac gcgcactccg accccgtacc cgcgcggggc
     2221 ggcggcccgt cgccgtccgg accacgggcg gggcggaccg ttccggtgcg gtgggaaccg
     2281 cgggcggcta ccccgcccgg ggggccgggg tgcccaggcc gtagacgcgg cgggcgttgt
     2341 ccgcccccag cagcgccgcc acccggcggg cgtcgcggcg cgaccaggcg ccctccgcca
     2401 cccagtgggt cagcagcccg gtcagcgcct cccggaagag ccgcgccccc accacataca
     2461 gttcgggcag accgtaggcg tcggtcgaga agagcacctt gccgaacggg gccagctcca
     2521 gcatctcccc gagcacggcc ccggcccgtg ccccggtgtg cgacagggcc agccccacat
     2581 cggcgtacac atgcgggaag acggcggcca gataggcggc gccgcggtgg tacggatagc
     2641 cgtgcagcag gatcagggtg cagcccgtgg gtcgcacggc ccggacgaag tcggtgaggg
     2701 cgagcggatc gcagcggtcc agccgcagat cggggtcgcc gaagccggtg tgcagctgga
     2761 gcggcagccc ggtgtacgcc gccgaccaca gcagatggcg cagcagtacg gggtcggtga
     2821 cccgggcggc ggcggtgccg ccctggccgc gccgggcgag ccagcgctcg gcggcggtgt
     2881 ggacggcgcc ggggcccggc ggatcgggtt cgaagtccag tccgtagcgg taggcggcca
     2941 ccgatttgaa tccggccgcc gtacgggccg cctcccggat cccgtccgcc accccggtca
     3001 ggaagtcgtc ggcggtcagc gaggtgtcgg cgatccgctc ggccaactgc tccagccgga
     3061 cgatctcatg ggcggtgccg cccgccgcga gggccagctc ctggggggtg gtcagattgc
     3121 ccggcagccc ggtgtccacc aggaactcgc tgatcccggt ggcgctcagc agccgccggg
     3181 ccacctcccg ggcgcccagc tcgcgccgcc gggcgaggta gtgggcgggc gggcagtgcg
     3241 gttcgaggcc cagcagcggc ggacaccagc ggcgcaccgc gaaccccagc tggctgtcga
     3301 agaaagtggt gccgagcgcg gcgggcgcgt cggattcggt caggaacgcc tcgaacgccg
     3361 ccgagcccag ctcggagcgg accaccccat ggcagtggtg gtccaccagg ggcggcagcg
     3421 gcggctcggt cggatccgtc tgctcggcgg cctccatcgg tcagtaccgc ctccgggtcg
     3481 cgatggcgat ctcacgcggg gacgacttct cgaacagggc ggcctccgcc cggcgcaccg
     3541 cggcgatgga ctcgaagagc ggatcgccca gcgcctcgcg cagcaccgtc gagtcctcga
     3601 agtgctcgag cgccgtcagc agcgacgtgg gcagccgccg ctcgcgcccc tcgaccgcgg
     3661 ggtccccgga gacgggcggc ggcagggaga gcccggcgtc cagcccgccg aggcccgcgg
     3721 cgatgaccgc gcccgccacc agataggggt tggccgccgg gtcgaaggac ttgatctcgg
     3781 cgttggcggc ccccgggtcg tccggtgcgc cggtgatgaa gcgcaccgcg gcctcgcggt
     3841 tctccagacc ccagcactgg tacgccccgg cccagcggga gggttcgagc cggaggtagc
     3901 tcgcggggga gggggcgccg atggcgagca gggcgggcag ttcgcgcagc accccggcga
     3961 ggaacgcctc ggccgtcgcg gtcatggcgt gcggtccgtc gccgtcccgg cacagattgc
     4021 ggtcaccctg ccacaggctc agatggagat gggcgccgtt gccgaccccg cccgggtcca
     4081 ccaccgggcc gaacatcggg ttgagcccgg cgcgcccgga gcacgcccgg atcgtctccc
     4141 gcaccagcac ggcgaggtcg gcggcggcca ccggatcggt gggcgccagg gacacctcga
     4201 actggccggg ggagtactcc ggatggagct ggtgcacctc ggtgtgctgt gcgtccagcg
     4261 cgccgagcag atcggcgaga tagtcggcga ggtcgaccag gcgcgccatg ccgtaggcgg
     4321 ggccggtggt ggggtagtgc ggcgggtcct ggtccgggtc gcccgtggtg acgacccatt
     4381 cggtctcgaa ccccatgcgc acggccagcc cccgctcccg tgcccgctcg gccatccgcc
     4441 gggcgaacag ccgctggcag acggggtgcg cccggccctc ctggtcgtac cggtcgaccg
     4501 gggcccaggc ccagccgggc tgtgcggcca gtggggtgag ccgctccagg tcggggagga
     4561 gccgcagatc cccgtcgggg ccgccgacat ggcggctggt ggtcatggag tcgtccacga
     4621 gatagacgtc gaagacgggg gacatcccga ccccgcgccg cgcggcctgg ggcagccgcg
     4681 cggtgggcac ggacttcacc cgggtcagac ccgcgttgtc cacccaggtc agcgcgatgc
     4741 cctggattcc gttcgcggtg agccgctcgg cctcctgccg cgcccgtgcg tatgcctgct
     4801 cacgatcccc ggtccccatg ggtgcctcct cagccacggc ttgtacgccg agactattgc
     4861 ctgaggacgg acttgtggtg acgcattgtc ccgatcgcat acggggtgtg acggtggctt
     4921 atgccggtcg gaggttgaca cgggcggccg gggcgtcgag gggccgaccc ggccgtggag
     4981 gggttcggtt tcggccacct gaggtgcccg cggtcagcgc ccgggacgcc cgccgtcggc
     5041 gccggaggcg cccggtgccg cccggtgcca ccgtctgggg cgcccggtgt cagcgcccga
     5101 ggtgctcggt gatgtcgcgc agtacgaccc gggcggcggt gggcccggcg ttgaggtacc
     5161 aggggtcgtc gtcgaccttg gcgatatgcc cgccgcggac cgcgcccagc ttcttccaca
     5221 gcggattgga cagataggtg gcggcgtcgg tcttcccggg gcggccctgg acggagtaga
     5281 agatccagtc gccgtccatc tgcgggatcc gctcaccgct gaggtcctgt gagatgtcgt
     5341 cgaaacgctg ggactcgggg cggccgagcc ccatgtcgtc ggcgatggtg ccggtgaagg
     5401 acttcttccc gaacatccgg acccggtcgg ggttgaagcg caccatcgac agcgccgtgt
     5461 gttcgccgcc cagcttctcg ccctggtcgg cggcgtcctt ctcgaagcgg gtgagcaggg
     5521 tgcgggcccg ctcgcgcctg cccaccgcgt cggcgacggt cagcaggtcc ttcttccagt
     5581 tcaccccgcg gcccttggtg accacggtcg gggcgatggc cgccaggctg gggtagaggg
     5641 cgccctgggt gctgttgacc aggatcagat cgggcttggc ggcggccagc ttctccaggt
     5701 tgggggaggt gcgggtgccg atgtccgtca tcgagccgag cgcctcggcc tgcccgggga
     5761 aggccgtgcg cagatagtcg gggacgagtc cggcgtagtc ggcacgggtg gtggccaccg
     5821 gtacgacgcc gagggtgagc agatcgtcga gctgtccggt gctgatcgcg gcgatgcgct
     5881 tcggcgcggc cttcagcggc gtactgccct gctcatgggc gacggtgcgc gggaagtcac
     5941 cgtccgccgc ggaggacccc ggagccttcg agaccgccga agaccccgaa gaccccgaag
     6001 accccgatga ccccgaagac gccgatgacg acgcgggagc cgaggatccg cagccggtga
     6061 caagggtcgc ggcgaggacg gccgagagca gggggaacag acgaaggggg cccacgagca
     6121 actccaatag ataaggtcag gcttacctta ccttggcggg attcggtctt gacgggcccg
     6181 gctcatcctc gcctttcctc cgcttttgtt ccggtacgga gtgtgtgccg atattcttga
     6241 cgtgtacatg gcgcctctaa ggcgtcctga cacccaagga ggactgaatg atcagtcgca
     6301 gaacgctgtt cgcgagcaca ctgggcctca ccggtggtct tctcctcccg acggcgggcg
     6361 ccggcgcggc gcccgccgac tggtcgcggg cggtggtgga ctccaccatc gcccgccgcc
     6421 cggaccccgc gtccctcggc ggctggggct acatccaggg gctgttcctg ctcggcacct
     6481 accgcgtcca ccagcgggtc gatgagccgt cgtacctggc gtacatcaag cgctgggtgg
     6541 acaacttcgt cgacgccgac ggccatatga gccggacctt cgacaacctc gacgcgatgc
     6601 aggccggcaa tctgctgctg atcctccacc aggagaccgg cgacccccgc taccggaccg
     6661 ccgccggcca gatccgggcc cggatcacca cctatccgcg caccgccgac ggcgggatgt
     6721 ggcacgccac cggcaggacc aacgaactgt ggggcgacgg ggtcttcatg gcccagccgt
     6781 tcctgctgcg ctacggcatc gcctacggcg accaggagta cgcgtacgag gaggtcacca
     6841 ggaacctctc ggtgtacttc cgccacctca aggcggccaa cgggctaatc taccacggct
     6901 atgacgccga cggcgacgcc ccgtggaagc ccgaccccac caccggcacc tccgcccact
     6961 tctgggcccg ggccatcggc tggaccgcga tgacccatgt cgaggtgctg gaactgctcc
     7021 ccgccgacca tccgcgccgc gccgaactga tcgacaacgt acggcacctg gcgaagggct
     7081 tcgcgcgcta ccaggacccg gccaccggcc gctggttcca ggtggtcgac aaggcgagcg
     7141 agcccggcaa ctggaccgag acctcggcct ccagcatgta caccctgatg ctgcacgcgg
     7201 ccctggagca cggctggatc agcggcggcg gctacaccga ggcggtgcga aggggctatg
     7261 agggcgtgct gcgtaaggtg tcggtcggct ccgacgggct gacgaacatc accgatatca
     7321 gcgagggcac caacgtcggg gatctggcct actacctcgg ccgcgcgcgc aatacgaacg
     7381 acctccacgg tctgggcgcc ttcctgctga tgaacgagcg gctcgcgcac tgacacgggc
     7441 gtacggtcgc ggcccggcgg accgcgaccg tacgcatcac ccatccgcga cggggctact
     7501 tcaactcgac ctggaacacc ttgtccgcgc cgtccggctc cccgccgttg ctgtcggcgt
     7561 tcgtcgtgga cagccacagc gtgttcttgc ccggcacggt ctccacggtg cgcagccgcc
     7621 cgtaggagct ggtgtagtac gccttcgggg tgcccgcgtt cgtcccgtcc accgggatcc
     7681 gccacagccg ctcaccgcgc agcgccgcca ggtacatccc gccgtcggcg taggtgaccc
     7741 cgctgggcga ggcgtcgccg gtcggccact ggcgcttggg gccggtcatc ccggcggtgg
     7801 agcactcgcc ctcgcagatc ggccagccgt agttcttgcc cgcctcgatg aggttgagct
     7861 cgtcgtactt gctgtcgccg aattcggcct cccacagccg gccctgcggg tcccaggtga
     7921 tgccctgcgg attgcggtgg ccgtaggagt agacgagcgt gccgaacgga ttgcccgggg
     7981 cgggcttgcc gtccgtggcc atacgcagga tcttcccgtt gagcgagttc ttgtcctggg
     8041 agagatcggg tgtctgcgcc tcgccggtgg tggcgtagag atagccgtcc gggccgaact
     8101 tgaggcgtcc gccgttgtgg tacttgttct tcttgatgcc ggtgacgagg gtctggtagc
     8161 cgtcgagcga ggagccgtcg taggtcatcc gggctatccg gttgccctcg gaggcggtgt
     8221 gcatcagata gatggtgtgg tcgctgttcc agttcgggga gaccgcgatg cccagcagcc
     8281 cgccctcacc gtcggtggtc accacattgg gcaccgtgcc cacctctgtc ctggtgcccg
     8341 actgggtgag cttgtagagc ttgaacgagt cccgctcggt gatcagggcc gagccgtcgg
     8401 gcagccagct cagcccccag gggacggtcc agccggacga gacggtcttg atgtccgagg
     8461 gagccgaatc ggcccggccg ggagcggcgg ttcccgttcc ggccgtcccg atcagcaggc
     8521 cggcggcgag cgcggtggcg gccgccgcgg cggcggtgtt ccggtacctc ttcatcccgt
     8581 tctcctgtct gatccccgtt catatgcggg gaacggtaag gaaggcttac taatgcgtca
     8641 acagattcga cagcaggggg ccggtgcatc gcggaaggta ggaggtgtct ctcggggcgt
     8701 caagcattgg tacgggccaa gaagccggcc acgtggtcga tttcacgccc tcagggctgt
     8761 cgaaccatca gaggtcggat gacctttttg gtgcacgctt cttgaccacg tcccgacggc
     8821 tggtgaccct gcaacagacg gaacaccatg cgcatcccct ccctcggcct tcacagctcg
     8881 aagaaggaga gccctcatgg accgagatcg ctgacggccc gtccgttccg tcctgtggac
     8941 cgatttccca ccagatggaa ggcaggtcga aaccatgaac gacaccaccc cgcgcaccgc
     9001 gcccgaggcg gcggaccgca cccgcaccga cgccgggcag accgcctggc agacccccga
     9061 ctacgtggtc gtggagaccg cgctggaggt caccgcctac tcgctgaacg cccgctgagc
     9121 cccccgccat gcgcgtgcgc gtgctcggca ccgcggcggg tggcggcgta ccccagtgga
     9181 actgcgcgtg ccccggatgc tccggggcac gcgcccaccc cgggtggcgc cgccgccacg
     9241 cctcgctcgc cgtccaggcc gccgaaggcc gctggtacct cgtcaacgcc acccccgacc
     9301 tcggcgacca ggtcgaggac caccccgaac tgcaccccgg gcccgaaccg cgccgcaccc
     9361 cgctggccgg ggtgatcctc accgacgccg aactcgacca caccctcggc atcgcccggc
     9421 tgcgcgaggc ggacggcatc gagatcgtgg ccaccgccat gggccatctg ccgatcgacg
     9481 gaccgaacgg cacggcgcac cggctctccg cgctgaaagc ccgcaccccg tacacccacc
     9541 tcaacaacac caaccgttcc tgagcagtga gcaggggtga gcccacgcac tggcacgccc
     9601 caaacggttt tgggcgtact ggtccccggc gtactcgacc ccggggcggc gacacggatc
     9661 ctgtccgtgg tccggtcccg ggaggccggt tccctgcgcg acttggcctg tgggcccggc
     9721 cagaggcgac ggggaggccc tgaaccatca ctccggtgga gcaggggccc cgcacgctgg
     9781 caccgaaccc ggcgtcccag atcgcgactt cacgctaccc cgacccgcaa agaccaccgc
     9841 aaccccggaa accgaccatc acacgatcga gctaaaacga cctcacgctc acccctcgat
     9901 cagcagctgg cacccccttc aacgacccgg ccgcgccgca ccacacggag ctgcgcaagc
     9961 tgggtgtcga ggtggccgcc gacgggatgg tgatcgacct gtgagcaccc cacgcacacg
    10021 gctggaggag cggctgcgcg cggtcgcgca ggagcgctac cacgaccgcc accccttcaa
    10081 cgtacggatg cacgcgggtg agctcacccc cgccgaactg cgccgctgga tcctcaaccg
    10141 cttccactac cagcgccata tccccgtcaa ggacgccctg atcaccgcca aattcgacac
    10201 cccacggctg cgccggatgt ggctgcggcg catccaggac cacgacggca ccaccgaagg
    10261 cgagggcggt atcgagcggt ggctgcggct cggcgaggcc gccggtctgc accgggaccg
    10321 gctgctgtcg gccgaggagg tggtgcccgg ggtgcggctc gcggtcgacg gctacgtcaa
    10381 cttctgccgg ctgcgcggtc ccctggaagc cgtcgccgcc tcgctcaccg aactgtccgc
    10441 gcccggcatc atgctcaccc gtatcgacgc cttcgagcgg tactacccat ggatcgagcg
    10501 cgagggcctg acctacttcc gcaaccgggt cgaccagggg cgccgggaca gcaccgaggc
    10561 cctcgacgcc gtcctgacct gggcacgcac ccccgaggac gaggaccgcg cggtggcggc
    10621 gctcgccttc aaatgcgatg tgctgtggtc gctgctggac gcggtggacc acgccgacac
    10681 caaggacggc cccgaggagg ggacatgacc gccgccggca ccccgcccgc cccggccgga
    10741 tggcggcccg cgctggcccc cgcggtgagc ctgcgccacg accgggtgcg cgacgccgat
    10801 ctgctggtgc tgcccgagcg ggtggtggtg ctgcgcggca gcgccgcgcg gatcctgcgg
    10861 ctgtgcgacg gcgaccgcga cctcgaggcc atcgtggcgg agctcgaaag ccgcttcccc
    10921 ggcgcgcccg tggccgatga tgtgcgtgcc ttcctcggcc ggatgcgcgg ggagggctgg
    10981 gtccgatgac cgccgcgccc cgcccctggg ccctgctcgc cgagctcacc cacggctgcc
    11041 cgctgcactg cccctactgc tccaacccgc tggagctggt ccgccgctcc cgtgagctgt
    11101 ccaccgccga gtgggcggag gtgatgcgcc aggccgggga gttcggcgtg gtgcacaccc
    11161 atctctccgg cggggagccg ctgttgcgtg gcgatctggc cgagatcgtc accgccgccg
    11221 agtccgccgg gatctacacc cagctcgtca ccagcggagt gggcctggac ggcgcccggc
    11281 tgaccgcgct gaccgccgcc gggctgcgca gcgtccagct gtccgtgcag cacgccgacc
    11341 cggccgccgc agaccggatc gccggacacc gcgccttcgc cgccaaggag cgggccgccg
    11401 ccctggtgcg cgcggccgga ctgccgctcg gcatcaatgt ggtcctgcac cgcgacaacc
    11461 tcgacgcgct cgacgccctc atccggcgcg gcgtggactg gggcgccgac cggatcgagc
    11521 tggccaacac ccagttctac ggctgggcgc tgcgcaaccg ggacgccctg ctgcccaccc
    11581 gcgaccagct cgcccgggcg cgggagacgg tccagcgctg gcgggaccgg ctgggcgggg
    11641 ccaccgacct ggtgtgggtc gtgcccgact acttcgacgg ggtcgccaag ccctgtatgg
    11701 gcggctgggg cgcggtctcg ctgaccgtcg cgcccgacgg caccgcgctg ccctgccccg
    11761 ccgccgcgag cctgccggac ctggacccgc ccaatgtccg tgaccactcc ctggagtgga
    11821 tctgggacca ctcgggcgcc ttcaaccgct accggggcga ggggtggatg cgggagccgt
    11881 gccgcacctg ctcccgccgc gcggaggact tcggcggctg ccgctgccag gcgtacgccc
    11941 tgaccggcga cgccacccgc accgacccgg cctgtgcgct ctcccccgac cacggggtga
    12001 tccgcgcgct gacggacgcc ggacacccgg ccgcggcggc caccccggcg ccgaccggcg
    12061 gctatgcgta ccgcaagccc ggaggagggt gacgcgggcc acggtttggc gcatacgccc
    12121 ccgcttccgt acagtttcgc cgttgtccag gggaacagac gaaccagaaa gcggcagcgg
    12181 cgatgacggt gactgacgaa ggccgggccg agcgggcgac ggccgagggg ccgggcatcg
    12241 acccggagcg gctggcgacc tgtctgagcg tgctggcgga actcgaccgg ctgccggtcg
    12301 accaccccga cgcgatcacc gtccgccggg ccacctccgg gatctaccgc agtgtgaagc
    12361 agcgtaggcg ccaggagcgg cgggccgcga agaccgccaa cgacaaggcc gtcaccgagg
    12421 ccaccgccac cggcgccgcg gaccggatcg acgacgagac gctgggcctc gcgctcacca
    12481 gctccgtcag caccgagatc gcgggcatcc tggcgcgccc ccgctcctgc tacgtctgca
    12541 agacccggta tgtcgaggtc gacgccttct accaccagct gtgccgcgac tgcgccgccg
    12601 agaaccgggc ccgccgtgac gcccgcaccg atctcaccgg gcgccgcgcc ctgctcaccg
    12661 gcggccgcgc gaagatcggg atgtatatcg cgctgcgact gctgcgcgac ggcgcgcaca
    12721 ccaccgtcac cacccgcttc cccggcgacg ccgtccgccg cttcaaggcc atgccggaca
    12781 gcgcggagtg gctgcaccgg ctcaaggtcg tcggtatcga tctgcgtgac cccgcccagg
    12841 tcatcgcgct gaccgacgag gtgagcgccg cgggcccgct ggacatactg atcaacaacg
    12901 ccgcccagac cgtgcgccgc acaccccagg cgtacgccga gctgatagcg ggcgagtcgg
    12961 cgccgccgcc cgccggggag ctccccgagt ccctggtcct cggcgccttc ggcagcggcg
    13021 cccaggcggc cctgccgggc ccccgcgcgg cacgggacgg cgccctcacc ccgcaggacc
    13081 tcaccgccct cgccctcacc agcggctccg cctcaccggc ccggatcgag gccgggaccg
    13141 cgatcgacgc gggcgggctg gtgccggacc tggacccgac caacacctgg gtgcagcggg
    13201 ttgacgaggt ggacccggtc gagctgctgg aggtccagct gtgcaatgag acggcgccgt
    13261 tcatcctggt gagccggttg cgcccggcga tggcggcctc gcccgcccgg cgcaagtacg
    13321 tggtcaacgt ctccgcgatg gagggcaagt tcggtcgggg ctacaagggc gcgggccatc
    13381 cgcacaccaa tatggccaag gccgcgctga acatgctgac ccgcaccagc gcacgggaga
    13441 tgttcgaggc cgactccatc ctgatgacga gcgtcgacac cggatggatc accgacgagc
    13501 gcccgcatcc ggagaagata cggctggcgg ccgagggctt ccacgccccg ctcgacctgg
    13561 tggacggcgc ggcgcgggtc tacgacccga tcgtccgggg cgaggcgggc gaggacctct
    13621 tcggctgctt cctgaaggac tacgccccga cgtcctggta ggcccggacg tcctggtgcg
    13681 ctgggacgcc ctggtaagcc gggacatccg ggtgcgcccc ggtgtccgcg tccgccccga
    13741 catccgcgta cgccccggtg tccgggtact ccccggcgtc ctggcgggcg ccccgctcgg
    13801 ccggggcgcc gtccacccgc gcggtgccgg atacgcggcc ccgcccgggg ttacgcgctc
    13861 gccttctcgc ccgccgccgg ggtgcggcgg cggccggggg cgatgccgaa gcggcgggcc
    13921 aggcgccgcc agcgggcgcg ggcggcggtc cggtagcgct cccagccgcg ggcgaaccgg
    13981 ctcgtgcgca gctcctcgaa gagctggtcg tagcgccggg cgatcggcgc ggggtcatag
    14041 atccgggagc cctccagggc ggccgcgccc atcgcccgcc gggccggggc gtcggccatc
    14101 agctccatca gggcgctcgc cagcgcgtgc ttgtccccgg tggggacgag ccgcccggtg
    14161 accccgtccc ggatgatctc ggcggggccc agcgggcagt cggtgctcac caccggcacc
    14221 ccgcagcgca tggcctccac gatcgtcatc ccgaacgact cggcgtccga tgcgaccgcg
    14281 accagcgacg ccttcgcgaa ctccgcctcg atgggggagt aggaccccat cagctccgcg
    14341 ctcccggaca ggcccagccg ctcgatgtgc tccgccagcc gctccttctc cgcgcccccg
    14401 ccgtagatcc gcagccgcca gtccgggtac ttctccgaga cctccgcgaa ggcgtcgatc
    14461 agcaggtcga agcgtttgcc gcggaccagc cgcccggccg ccgcgatcac cggtgcggtg
    14521 ccctcggagg gggcgacggc cggttcgggg acgctgttgg gtatcgcgag ggtcagcacc
    14581 cccggcatcg gcatcttctc gcggtagacc gcggcgtccg cctccgtcgt ggtgaccacg
    14641 gcgtccagcg accggtagta cggggccagc tccgcccgca gcttcttgct gtgcgcctcg
    14701 taccgcagat gctcctgggc gatgcgcagg gcacggcggg gggcgaagcg ggatatgtag
    14761 acgttcaccc ccggccgagt gccgacgatc acatcggcgg ggcagtcgcg cagatactcc
    14821 gcggcccgtg tgtcgatcag gcggttgtac tggtggtgcc gcttctcggc ggccgggaag
    14881 tcccggctgg cctcgaagaa cagcgggtcc ttcgcgtccg cgccgtttgg acgcgtgtcc
    14941 accaggggga ccagccgcac ccgggggtcg agggcgaaac gcggcgtctc gcggtgccgc
    15001 atcatcgaga cgatctcgac ctcgtgacgg tcggcgagcg ccgtcgcgag gttcatcgtc
    15061 gtccggatcg ttccgccgat cccgtaggcg ttgtgcagca ggaatgcgat cttcatgcgg
    15121 tattttctcc ggccggttgc attcccgggg cgtgttcccc ccggaacata gcggacacct
    15181 tgccgaggtc cggtaagccc gtcgcgtgaa gaaggtgaga gcggggtaag aagcaccgct
    15241 cgggaccccc gcccgcgacg ggcaccgctg tggccttggc agactcgggg tgtgaccaac
    15301 accgtgctgc tcgccgagga cgaccgtgcc atccgccagg cgctggaacg cgccctgacc
    15361 ctggaggggt accgcgtcac cggcgtgccc gacgggatcg aggcgctggc ggccatccac
    15421 cgcgagcgcc cggacgtggt ggtcctggat gtgatgatgc cgggcgtgga cgggctccag
    15481 gtgtgccggg tgctgcgcgc cgaaggggac cgcaccccca tcctcatgct caccgcgcgg
    15541 gtcgagaccg ccgaccggat cgagggtctc gacgccggcg ccgacgacta tgtggccaag
    15601 cccttcgagg tcgaggaggt cttcgcccgg ctgcgcgcgc tgctgcgccg ggccgccccc
    15661 gccgaaccgg ccgcgccgga ggacaccgcc atcgacgggg tgctggaggt ctcggacctg
    15721 cgcctggact cctcggcgcg gcgggtctgg cgcggcggta cggagctgga gctgacccgt
    15781 accgaattcg acctgctgga gctgctggcg cgcaacgcgg gcatcgtcct ggaccacgcc
    15841 acgatctacg cccgcatctg gggctacgac ttcggcccgg gttcgaagaa tctcgcggtc
    15901 tacatcggct atctgcgccg caaggtcgat ccggaggggc gcaccccgct gatccatacg
    15961 gtgcgcgggg tcggttacac cctgcgggag gagtgatggt gcggctccca cggctccgcc
    16021 gcaggcggcc cagtctgcgg accaccttcg cgctctcgtt ctcggcggcc gccaccgtgg
    16081 tcaccctcct ggtcggcggt ctcagctatg acgcggcggc cgggctggtg cgggtggacc
    16141 agcagtcggc gttcgacgac gtcatccacg atctgcgcgg ccaggtccgt ggcgacaagg
    16201 tggtcctgcg gcagtacccc accgagtcca ccgggcctgt cccgtacgac ctgcgggacg
    16261 atctgcgccg gatcagccgg atggacgtcc aggtgatcaa cggccggggc acggtctacg
    16321 acgcgggcaa gcccccgctg ccggtgaccg acgaggaccg gacgaccgcc gccgcccaca
    16381 cggccggcac cgtcgtacgg cgcgagatcg acatcggcgg ggagcagtac cgcatggcca
    16441 cggtggccgt gggcgacggc accggcgcgg ttcaggtggc ccagcagatc agcgacaccg
    16501 aggatctgct gcaagagctc cagcagcgca ccgcgctctt cgtggtcgcc gtcatcctcg
    16561 cggccgggct ggccggctgg tggctggccg ggcggatcac ccggcggctg gtgcggctga
    16621 cccgggtcgc cgagagcgtg gccgcgaccg gccggatgga ggtggcggtg ccggtcgccg
    16681 gggacgacga ggtgggccgc ctcggacggg ccttcgacgg catgctcgga cagctcgcgc
    16741 gctccaagga cgaccagcgg cggctggtcc aggacgccgg gcatgagctg cgcaccccgc
    16801 tcacctcgct gcgcaccaat atctccctgc tgcgccgctt cgaggatctg ccggggcccg
    16861 cgcgggagga tctgctggcc gatctggcgg gggagacccg tgagctgacc gacctcgtca
    16921 acgaactggt ggacctggcg gccgggcagc gggacgacga accccgtacg gaggtcttgc
    16981 tggaggaggt ggccaccacc gccgtgaccc tcgcccggcg ccggaccggc cgcgagatca
    17041 ccgtacgggc cagtggcgac acccgtctga cgggccaccc ggccaccctt cagcgcgcga
    17101 tctccaatct ggtggagaac gccgccaagt tcgatcagga cggcactgag cccgtcgagg
    17161 tgatgatcag cggccgccgg gtggaggtgc tggaccgggg tccgggcatc gccgcggagg
    17221 accgcgagcg ggtcttcgac cgcttctacc gcgcccccgg ggcgcgcagc ctgcccggtt
    17281 ccgggctggg tcttgccatc gtgcgcgagg tcgccctcgc gcacggcggc accgtcttcg
    17341 cccggccgcg cccgggcggg ggcgcgatac tgggcttcac ggtcggcgac ggcaccgggt
    17401 cgatcggcac cgggccgtga ggcccggtcc cggggcccgg gcccctagga cttccgggcc
    17461 actcccgccc acatgttgat gtccgcgctg cggatggcct ccgggcggtc accggggtcc
    17521 ggcttccact ggtggggctc cgacacaccc gggtcgatca gctccagacc gtcgaagaac
    17581 gccccgacct cgctctggga gcgggtggtg aaggagattc cgctctcctt gtagacctgg
    17641 atgacgttcc gccaggtctc ctccgagaag tcatgggtgg agtgggtcag catcagatag
    17701 ctgcccggga ccagaggctc catcagcttg cggacgatct cgtacggctt gtcctcttcc
    17761 ggaatgaagt ggaagagcgc gttcaccgag atcgccaccg gctgggtcag gtccagcgtc
    17821 tcgtgcagct cgggggcgct catgatccgc tcggggtcgc gcacatccga ctgcacatag
    17881 gccgtacggc cctcgggggt gccgatgagc agcgcctggg cgtaggccag cacgatgggg
    17941 tcgtagtcgg tgtagaccac ccgggcctcc gggatgacgc cctgggcgac ctggtggagg
    18001 ttgggctcgg tgggtatccc ggtgccgatg tcgaggaact gccggacccc ggcctcccgg
    18061 gccagccagc gggtggcgcg gtggatgaag ccccggttga cggtcgcgtt gagccggacg
    18121 gtcggataga cctccagcac ccgcccggcg gcctccgcgt cgacctcgta gtggtccttg
    18181 ccgttgaggt agaagtcgta catccgagcc gggtgcggct tggtggtgtc gatctggtca
    18241 ggggcgagcc cgtagtcggt cacgcggccc tccgttccgg tgcggaaccc gccgaggtgg
    18301 tcaggttttc tgggcgtgtg agcaggaagt ccgcggcgcc ggccttggcg ccctggatga
    18361 acctctcgat ttcatggtgg gtgtagatca gggcagggcc gtccggatcg gtcgactgac
    18421 gcagggcgac ccgcccgtcc ttcagccgca gggcctccac acaggcaccg ccgttggggc
    18481 cgctccaggg cttggcccag ccttcgatcg ccagctgttt ggccggcatg ccgttgtaca
    18541 catctacctg atccacagtc agagctcctt gcgaatccca cggagaaagc tctccgtgcg
    18601 ccgcgccggt gtggcctggg tgcccatgcg gtccagggcc tccagatacg cgaccacatc
    18661 ggaacgttgg tcgagatagc cggcgccggt caggccctcg gcatagacga tgtccggcag
    18721 ttccgggatc tggaaccgga agagctggaa ggggccgccc atgcccgggt gcgggccggc
    18781 ggagaacggc accacctgaa gggtgacgtt cggtctttgc gcggcctcga tcagatggtc
    18841 cacctgggcg cgcatcacct cggggccgcc gatggccaga cggagcaccg tctcgtccat
    18901 cacgacccac agatgtggtc cgttcgggcg gtggagcagc tcctggcgct ccatccgcag
    18961 ggccacccgg cgctcgagct cccggtcgga cccgtgcggg aaaccgatgg agaggagcgt
    19021 gcgggcgtag tcctcggtct gaagcagccc ggggacgaag tgcggctcgt aggcgcggat
    19081 acggctggcc gcgccctcga ggctcacata gagactgaac cagtccggca gcacatcacg
    19141 gaaccggtgc caccagccgg gcctgttggc ctcctcggcg agtgcgagga aggagtcgat
    19201 ctcttcctgg tcggcgccat aggtttgcag cagcttctcg acgtagggca gtttcaggcc
    19261 gacttcggcc ttctccatcc tgcgcaccgt ggtctggttg acgtgcagcg ccctggcagc
    19321 ctggtcgtag ttgacgccgg ctttctcgcg aaggtcccgc agccgcatgc cgaggaccat
    19381 ctgcccgacg gtcggggcag atcgcgcttc acccacgtcg tacctcctgg gacggtcttg
    19441 tcaggaatca gtgtgccacg tgcgaggtga gggcaacaga gtgcgctggc tattctgcat
    19501 tttgcagatc gcgccttgcc aactgatgct cgcagcaacg atagtgacgg gtgtgaccgg
    19561 tccaacgtga ctgctgtgtc gcgcacttgc ggcattcacg tacggcattc acgcccccac
    19621 aggtagacgg acggaaggca catggccgtg gcattgcgtc agcgctcgac gatggcccac
    19681 cacccgagcc ccgggagcgt tgactccgcc ctccgccagg agaggttcca gctgcccgcc
    19741 agaggcgcgt cggtcgccat cgcccggcac cgggtccgct cgcgcgtacc ggagtggggc
    19801 ttccacgagg atctctgtga cgccgccgag ctggtgatgt ccgagctgtt caccaacgcc
    19861 ctggtgcaca ccggaagcga gcagatcctc tgtgtgctgc gcgcccatga gcggcgcatg
    19921 ctctatgtcg aggtcgccga ccagggcggc ggaccggccg tccccacgcc gcgggaggcc
    19981 ggtcttgagg atgagtgcgg acgcggactg gcactggtcc gcgccctggc cgacgcgtgg
    20041 ggggacaggc cgggcgtgga cggcggacgg gtggtctggg cccagatgag cgtggccgtc
    20101 ggccgctgac ccggatccgg cccgccgccc ccgtcacacc gccgtcgtcc gctgcttccc
    20161 cggggcggcc gggccatcgg cgcggtcccg ggagagggcg gcgtcgcggg tctcccgcat
    20221 ggtgaggtag acgacgagcg agacggccgc acacgccgag acgtaccagt agtacccgga
    20281 ctccacaccg cccttcttga accacagcgc cacatactcg gcggtgccgc cgaacagcgc
    20341 gttcgccagc gcgtacggca gggccacccc gagcgcccgg acatgggtgg ggaacagctc
    20401 cgccttcacc accgcgttga tcgacgtgta gccggtgacg atgaccagcg ccgcgagcga
    20461 gagcagcagc gccccggtga aggtgtcggc gtgtgagagc gcggtcatga tgggcacggt
    20521 gcccagcatc gagccgaagc cgaaggtgat cagcagcgga cggcggccga tccggtccga
    20581 gagcgccccg gccagcggct gcaacagcat gaacaggaac agggcacaga agctgaccag
    20641 cgatgcgtcg gacttgctca ttccggccgt gttcgacagg tacttggtga gataggtggt
    20701 gtacgtgtag tacgcgaccg tgccgcccat ggtcagcgcg atgacgagcg ccgcctcctt
    20761 gcggtggcgc agcaactcgg cgatggtccc ccgctcctgg tcctggcggg cgtcctcctc
    20821 ggcgtagatc tcggtctcca gcagattgcg ccgcagccag aagaccacgg ccgcgcccac
    20881 ggcgccgacg atgaacggaa tgcgccagcc gtaggagtgc agcgcgtcat cggacatggt
    20941 gtgctggagc acgatctgga gaccgaggcc catcagctga cccatcgtca tcgacacgta
    21001 ctggaagctg gagacgaagc cccggccgcc gggccgggac gcctcggtga gataggtggc
    21061 gctggccgcg tactcaccgc ccaccgacag gccctggagc agccgcgcca ccagcagcac
    21121 gcccgcgccg aagtagccga cctggtcata ggtcggggcg atggcgatga gcagcgcgct
    21181 ggccgacatc agcgacaccg tcagggtgag cgccgcctta cggccgcgcc ggtcggcgaa
    21241 ccggcccagc agccagccgc cgacgggacg catgaagaac ccgaccgcga agatcccggc
    21301 ggtgttgagg agctgtgcgg tgtcgttgcc cttggggaag aaggctccgg cgaagtaggt
    21361 ggcgaaactg gcgtagacga accagtcgta ccactcgacg agatttccga tcgagccgcc
    21421 gaacacggct cgccagggtg tgcgtggttg gctccgggga gcgctgtcgg tcacggggcc
    21481 tccaagtgag cggggtgatc cctcacccct accccgcaca gggccagttg gaaaagggat
    21541 tccgcggcgg ggtcgcgccc ccgggtgacc ttcgtcgcgc ccccgggcga ccttctcggg
    21601 ccgagtggcc cggcgtccgg cggagcgctc agccccggcc ggtctccgcc agtgtcgcca
    21661 tccggcgctt gccccaggcg cccagcgggc gcagcgccgt attcagctcc tcgcccagcc
    21721 cggtcagcga atactccacc ttcggcggca ccacgtcgta gctctcccgg tggacgattc
    21781 cgtccgccgc caactccctc agctgctgtg tcagcacctt ttcactcaca ccgggaacaa
    21841 gccgcttcaa ttccccgaaa cggcaccgct ggtgattgag cgcccaaatg atcagcactt
    21901 tccacttgcc gtcgatcaca tccacggccg cgtccagacc gcagacatac ggctgctttt
    21961 ccatggcccc cactgacctc aaggtaagta cgcacttttt agtgcgtact tgtccacatt
    22021 accgccgagg aaggagtctg tgaccggcgc gccggacccc tacgacaaag cggtatcgga
    22081 acaactggag ca
//
