LOCUS       NZ_CP019458            21161 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces autolyticus strain CGMCC0516 chromosome, complete
            genome.
ACCESSION   NZ_CP019458
VERSION     NZ_CP019458.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces autolyticus
  ORGANISM  Streptomyces autolyticus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10029028)
  AUTHORS   Yin,M., Jiang,M., Ren,Z., Dong,Y. and Lu,T.
  TITLE     The complete genome sequence of Streptomyces autolyticus CGMCC 0516,
            the producer of geldanamycin, autolytimycin, reblastatin and
            elaiophylin
  JOURNAL   J Biotechnol 252, 27-31 (2017)
   PUBMED   28472671
REFERENCE   2  (bases 1 to 10029028)
  AUTHORS   Yin,M., Jiang,M. and Lu,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2017) Yunnan University, Yunnan University, 2#
            Cuihu Beilu, Kunming, Yunnan 650091, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Analysis v. 2.3.0
            Genome Coverage                   :: 279x
            Sequencing Technology             :: Illumina; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 03:05:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,227
            CDSs (total)                      :: 8,141
            Genes (coding)                    :: 7,920
            CDSs (with protein)               :: 7,920
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 221
            CDSs (without protein)            :: 221
            Pseudo Genes (ambiguous residues) :: 0 of 221
            Pseudo Genes (frameshifted)       :: 74 of 221
            Pseudo Genes (incomplete)         :: 182 of 221
            Pseudo Genes (internal stop)      :: 9 of 221
            Pseudo Genes (multiple problems)  :: 42 of 221
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:31:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8608944
            Orig. end                         :: 8630105
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP019458.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21161
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="triceptide"
                     /region_number="38"
                     /rules="((cds(PF04055 and (TIGR04085 or SPASM)) and
                     triceptide_precursor) or triceptide_rSAM)"
                     /tool="antismash"
     cand_cluster    1..21161
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /kind="single"
                     /product="triceptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21161
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11161](+)"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /neighbourhood="10000"
                     /product="triceptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11161
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /neighbourhood="10000"
                     /product="triceptide"
                     /protocluster_number="1"
     misc_feature    complement(617..632)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.16"
                     /tool="antismash"
     gene            2063..2731
                     /locus_tag="BV401_RS35380"
                     /old_locus_tag="BV401_35450"
     CDS             2063..2731
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056010.1"
                     /locus_tag="BV401_RS35380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_35450"
                     /product="hypothetical protein"
                     /protein_id="WP_079259549.1"
                     /transl_table=11
                     /translation="MRKPLHSFRGAALGAVAAAAVVAVAGIGPAQAHTPSAGAGAEAPA
                     AVPQRTPAHLVPRELPPHPSSDWYAGDVTRGLPETPPFCVEKTLPSAGATHRTFWTEYD
                     TGATQIVVRTGTVDAARKLAAATEKRIRACAADWQGDYPQGTASWRDYGALTAEDGAHV
                     YGVHTSYPDSEPGIHLFGVGRDGRTVTVVSWGEMGGYEQAPLADFKRTTTTAVVKLYHP
                     "
     misc_feature    2066..2079
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.95"
                     /tool="antismash"
     misc_feature    complement(2981..2995)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     gene            3040..3720
                     /locus_tag="BV401_RS35385"
                     /old_locus_tag="BV401_35455"
     CDS             3040..3720
                     /GO_function="GO:0070273 - phosphatidylinositol-4-phosphate
                     binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056011.1"
                     /locus_tag="BV401_RS35385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_35455"
                     /product="GPP34 family phosphoprotein"
                     /protein_id="WP_069872459.1"
                     /transl_table=11
                     /translation="MPNGSLSLAASLYLLSYDPETGRPTAAHTALLVRAAALTELVQRG
                     MLTDADGCPCPVADAATGDRALDGLLELIGESRPRSWQIWVGHQPRLTEHAVRDQMVAA
                     GYLRAKGKRMLGLFPAREYTLERPEPVVGMRDDVVRVLHGEQPAAEVSERDAALVTLAA
                     AGELRTVVTATDAKVRKRRILALGERCGGMGPVLEKVIAQVRTALAAAVATAMLAATTA
                     VTAT"
     gene            complement(3761..4174)
                     /locus_tag="BV401_RS35390"
                     /old_locus_tag="BV401_35460"
     CDS             complement(3761..4174)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056012.1"
                     /locus_tag="BV401_RS35390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_35460"
                     /product="SsgA family sporulation/cell division regulator"
                     /protein_id="WP_069872456.1"
                     /transl_table=11
                     /translation="MTTVIDQAVQAQLIASTPESRAIPACLRYERDDPFAVRVSFPPSA
                     SLDGSEVEWTFGRELLAAGLRGPAGSGDVQMWPCGSRRTVLEFHAPEGMAMVQFDTADL
                     RRFLGRSYAVVPEGNEAGELDLDQGLASLLRDA"
     misc_feature    4146..4161
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.87"
                     /tool="antismash"
     misc_feature    complement(4262..4277)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.38"
                     /tool="antismash"
     gene            4403..5899
                     /locus_tag="BV401_RS35395"
                     /old_locus_tag="BV401_35465"
     CDS             4403..5899
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BV401_RS35395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BV401_35465"
                     /product="hypothetical protein"
                     /protein_id="WP_079259550.1"
                     /transl_table=11
                     /translation="MTEGHAALDAAAYARIYEAEYPRLCGYARTLTGNPWVAGDLVAEA
                     HYSVWRRLRAGHPLGADAIPDELTSAVRALSAGAGGWGPAQQASYLEPLVRVLDELPQR
                     WIKVLWLAEVDGLPPEEVARRAGMTDDDAAALVERVRESVRQEFLRAQPGYPASAACGA
                     HWERLPDHVRGADSPHQAEEIAVHIDGCRDCRGRMEQLVAADDRLPALVGPALLDLYDR
                     DMARFLAPLVAAGGAAAVAAAGAGAMTSGGAHAAPSNGPLVSSRRSMQHLVRGRVRQAG
                     PVAVAAAAGGVLLVAGAAVMTGLALTDGGSAEAQQPATASTPSISDTSDSSSASSGSSS
                     ASGTSGASRHSDGPRAGVPGEASRNRQSTSGVPAGHSPADVPSSAVSPSRKAPSSSSSA
                     SPSSRPSSPSSSASSSASSGPSHRPTGKPTGTPTGEPTGGGTADPGDTPSGRPTQRPTD
                     ESTQRPTTKPTDSGSASGSASGSGDSRDCVSLVVRLCVSR"
     misc_feature    complement(6240..6253)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: medium, score: 18.25"
                     /tool="antismash"
     misc_feature    6377..6391
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.09"
                     /tool="antismash"
     gene            6478..7326
                     /locus_tag="BV401_RS35400"
                     /old_locus_tag="BV401_35470"
     CDS             6478..7326
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014180874.1"
                     /locus_tag="BV401_RS35400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_35470"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_079259551.1"
                     /transl_table=11
                     /translation="MTFQPRELFPDRSARDLFGAEIRRHREKADMSLRRLSEVLNYSKS
                     HLARIEAAESLPYDDLPAKLDACFGADGLFARLYALAKNEPFPGKYRRMIELESQAVII
                     EQYVGATMPGLLQTPDTAECWLRCGRPHAPDAEIEAMVKARIDRQSLLDRPKPPRCWFI
                     LEEAVLRRPVGGLQVMHHQLTSLIERGAQPHVTLQVLPFTAGEHAETGGSLTLFTVPHG
                     ALVAYDESSQSGTIIEDQETVARRRENYDLLRAMALSPRDSEAMIRAVMKDWSPCQPPR
                     A"
     misc_feature    6697..6699
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7305..7505
                     /locus_tag="BV401_RS35405"
                     /old_locus_tag="BV401_35475"
     CDS             7305..7505
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056018.1"
                     /locus_tag="BV401_RS35405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_35475"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_079259552.1"
                     /transl_table=11
                     /translation="MPTTPGLSVATWRKSSYSNPDGGNCVEVADNLPGVIPVRDSKNPD
                     GPALIFAAGAWATFIASLKTG"
     gene            7509..7709
                     /locus_tag="BV401_RS35410"
                     /old_locus_tag="BV401_35480"
     CDS             7509..7709
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056019.1"
                     /locus_tag="BV401_RS35410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_35480"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_079259553.1"
                     /transl_table=11
                     /translation="MPTTPDLSAAAWRKSSYSNGDGGDCVEVADNFPGGVVPVRDSKNP
                     DGPAIPFPTKSWVAFIASLKA"
     misc_feature    complement(7740..7753)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.17"
                     /tool="antismash"
     gene            7846..9312
                     /locus_tag="BV401_RS35415"
                     /old_locus_tag="BV401_35485"
     CDS             7846..9312
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BV401_RS35415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BV401_35485"
                     /product="hypothetical protein"
                     /protein_id="WP_079259554.1"
                     /transl_table=11
                     /translation="MRKARAGLSAFEARAGEAARTLLHNQGYDGGWGLTLTSVSSIVNT
                     SEVLPILRAAGLAGQPVRKALDFLTGAIPEHCRPRHKGGRGEHTRFVAFGLTGLLSHPR
                     FFHHDGVVEAAVWCVGWLEDHRVDHGWPEVLGLDDTSLHQTALAVHGLAQLRDTLHELG
                     PGFVLPGGADTTSLLGRVEPLIDHGVHGLLYHRRSSGAWGWRTYVNTDPSPSKTALCLL
                     ALSAVASGAGPGGEPAYRDAPRDAGGVHGPVQKKRLTEAVVEAGQWLLRNHHRWETFVE
                     DDKDVQGTAWEHMAYALCTQAVIRAGANPRDPRLSTAWRLMNDLWEPEAGMWNEPGAFV
                     KRATIRAAYYTVSAYQEALGRLARIGIGEEIRAGNSDIAVEIPLRGAELAAGHTVLLTT
                     PDSDGPVACQLSERLFDLAKVVHDGPGEGMSTEQIAQALFVAPSSVPKYVQRLNQAVSA
                     ALGGTPARLLMADTVNGSGGYAWARSEATG"
     gene            complement(9279..9800)
                     /locus_tag="BV401_RS35420"
                     /old_locus_tag="BV401_35490"
     CDS             complement(9279..9800)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012514.4"
                     /locus_tag="BV401_RS35420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_35490"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_158525949.1"
                     /transl_table=11
                     /translation="MPRSILIHDGRTARDVGLVYICSGYLVERGKVLLVHHNRFDKWVP
                     PGGHIEPGESFAGTAVREFKEETGLLVEAISSQPAIHPADDNATPEPVPFYVDIEREGF
                     AIPALVQFFYVRRQAGTGEQAVEAQMEEVHGAGWFSLEDLEQLPTFEQVRSLARFALLN
                     YPVASERAQA"
     gene            10001..11161
                     /gene="amcB"
                     /locus_tag="BV401_RS35425"
                     /old_locus_tag="BV401_35495"
     CDS             10001..11161
                     /codon_start=1
                     /gene="amcB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     triceptide: triceptide_rSAM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF041718.1"
                     /locus_tag="BV401_RS35425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_35495"
                     /product="cyclophane-forming radical SAM peptide maturase
                     AmcB"
                     /protein_id="WP_079259556.1"
                     /sec_met_domain="PTHR43273 (E-value: 1.8e-50, bitscore:
                     170.9, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 7.9e-16, bitscore: 57.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="triceptide_rSAM (E-value: 1.0, bitscore:
                     1.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTRISGWRARYDQWFTVPQTVVVQPTTWCNLDCHYCYLPFRKLR
                     HHMRPDVAAALAMSVAQLTASGSPPIGIVWHGGEPLALGPQKFRALLAPFEDLRCAGRV
                     HHYVQTNATLITDTWCELLTAYDIRVGVSIDGPTALNTERVDLRGKPAFDRILHGVRRL
                     REHGIPFSVISVVATQSITQPEELLGFLAKLGCDSAGFNIEEVEGVNTDRQAPTPAQAE
                     EFWRRTLIWTRSHGDRLKVRELERLAEYLHLIRTGQRVAWDERRLDPIPTVSVAGDVVL
                     LSPELADTTDPVYDDFRAGNILHQPLPMILSGAHRLRYVRDFLTGLDRCRAGCAFFDFC
                     RGAQAANRYFENGSLKSTETNYCQVSRQALVTALSTLATKEKGRAT"
     misc_feature    11410..11428
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.99"
                     /tool="antismash"
     gene            11427..12113
                     /locus_tag="BV401_RS35435"
                     /old_locus_tag="BV401_35505"
     CDS             11427..12113
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024986.4"
                     /locus_tag="BV401_RS35435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_35505"
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="WP_079259558.1"
                     /transl_table=11
                     /translation="MGTRTIRRTSVTLPSLDEPGLYLSHVTSLEGGRGRVAEFHYGDAD
                     LRALDLADTHLIDGRISGLKTQRARLEKLRVDSVEFTGCDLSSLRWTDSKVTRAVFRDC
                     KLMGAMLEDVTLDDVLFENCKLDYSTFTRVRAVGPLIFSQCSLRETMFDAADLSTAAFE
                     GCDLRLAEFGGGTYRHLDLRGNDLSQLRGLASLKQVIIDHGQTPQLAEALAAELDVTYG
                     EDLDDK"
     gene            complement(12230..12514)
                     /locus_tag="BV401_RS35440"
                     /old_locus_tag="BV401_35510"
     CDS             complement(12230..12514)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056020.1"
                     /locus_tag="BV401_RS35440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_35510"
                     /product="YciI family protein"
                     /protein_id="WP_079259559.1"
                     /transl_table=11
                     /translation="MFVLEITYTASADRVEAALPEHLVWVDDHFANGAFLASGPKNPRD
                     GGVILALGDDRAKIEEMVASDPFIVAGVGEYTITEFLATRTAPALTEYR"
     misc_feature    complement(12508..12522)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.21"
                     /tool="antismash"
     gene            12545..13267
                     /locus_tag="BV401_RS35445"
                     /old_locus_tag="BV401_35515"
     CDS             12545..13267
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056021.1"
                     /locus_tag="BV401_RS35445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_35515"
                     /product="endonuclease V"
                     /protein_id="WP_079259560.1"
                     /transl_table=11
                     /translation="MTSAVDPRYELPRDWPSTEAEAIAVQERTRASVVVGGEVPAPDTG
                     PGAVVGVDVAYDDERDLVAAAAVALDARGLDIVAEATAVGRVTFPYVPGLLAFREIPAV
                     LDALGDLDRRLGRRPDLVVCDGYGLAHPRRFGLASHLGVLTGLPTIGVAKNLFGFRHAD
                     PGPRRGDWAPLLDGEEEVGRALRTRDGVKPLFVSVGHRVTITDACAYTLHLARDFRQPE
                     TTRRADALCRRALKAATL"
     misc_feature    12548..12562
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     gene            complement(13388..13891)
                     /locus_tag="BV401_RS35450"
                     /old_locus_tag="BV401_35520"
     CDS             complement(13388..13891)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056022.1"
                     /locus_tag="BV401_RS35450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_35520"
                     /product="DUF1203 domain-containing protein"
                     /protein_id="WP_237288059.1"
                     /transl_table=11
                     /translation="MSENHGEIYEMRAIAPEALKLLRTTDDAGHPPRLVVDDEEGGSPL
                     RCCLGRSRPYETIALVSYAPLRRWARETGAGPGPYDEVGPVFIHPEECDGWTGPGIAEG
                     IRGRRRVLRAYSAEGNILGGRLLDDGGPTIEEGLAEWYADPRVAAVHVRAVEFGCFLAE
                     TRRV"
     gene            14055..14993
                     /locus_tag="BV401_RS35455"
                     /old_locus_tag="BV401_35525"
     CDS             14055..14993
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056023.1"
                     /locus_tag="BV401_RS35455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_35525"
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="WP_079259562.1"
                     /transl_table=11
                     /translation="MSLPAPLTGVVPPLCTPFTPTGEVDTRSLAALAERLIDAGVSALF
                     ALGSSGEAAYLGDGGRRTALEAVIEAADGRVPVLAGAIDMTTARVLDHARTAAELGADA
                     VVATAPFYTRTHPVEIADHFRRLRHGVDLPLFAYDIPVSVHSKLTPSILLPLAADATLA
                     GVKDSSGDDGALRRLLVEVRRRGLIDSFTVLTGSELSVDGALLAGAHGVVPGLANVDPA
                     GFVRLYEHARAGRWERAAAEQDRLAALFAITAAGDPALMGGSSSGLGGFKAALRLLGVI
                     DCPDTAAPQVPLGGAAVKTVRQLLEEGGLLP"
     gene            14990..16447
                     /locus_tag="BV401_RS35460"
                     /old_locus_tag="BV401_35530"
     CDS             14990..16447
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1074: major
                     facilitator family transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056024.1"
                     /locus_tag="BV401_RS35460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_35530"
                     /product="sialate:H+ symport family MFS transporter"
                     /protein_id="WP_079259563.1"
                     /transl_table=11
                     /translation="MTEAAKVPWYREVLPGQWKSLFAAWIGYLLDGFDFVLITLVLTEI
                     ADEFDLSTASAASLVSGAFITRWLGGALLGALGDRYGRKAAMVVSILLYSLGTFACGFA
                     WNYLSLFTARLVIGMGMAGEYSASATYVLESWPARLRNRASGFLISGYSGGTIIASELY
                     KWVVPHWGWRWMFWIGVLPVLVALWVRRALPEAGDWHEEVAAARARPNPFRPLFAGRTR
                     AGVNTALTVAASVALFLVFTPPGAGWRWPLSILAAGCLVAFAAQLGGRRRWPLYVGLMC
                     TVFCAFLYSWPIQALLPTYLKEQLGYTPSEVTDVMFYAGFGTMAGCCLAGFVGDWLGTR
                     RAYAFTLLASLAFVFPVFAVRDTLVGLGVLLFFLLALSQGISGILPKYIAGHFPTESRA
                     ASLGFVYNTGALGGAVAPVLGAHLAEGMSLGRALAVLTFGLTLVVIVLVGTDVPRRLGR
                     LTDPAGDQDHLLPGQPLSTARPGVDTT"
     misc_feature    15029..15031
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            16623..17765
                     /locus_tag="BV401_RS35465"
                     /old_locus_tag="BV401_35535"
     CDS             16623..17765
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189: L-carnitine dehydratase/bile acid-inducible"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056025.1"
                     /locus_tag="BV401_RS35465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_35535"
                     /product="CaiB/BaiF CoA-transferase family protein"
                     /protein_id="WP_079259564.1"
                     /transl_table=11
                     /translation="MTVAEEGAAGPLAGVRVLELAGIGPGPFAAMVLGDLGADVVRVDR
                     PGGPRGPRMDPDFDLANRNKRSVLLDLKSEENVGVVLDLVERADILIEGYRPGVTERLG
                     LGPDDCLARNPKLVYGRMTGWGQEGPLAQSAGHDIGYIAVTGALSMIGTTDGPPIAPAN
                     LLGDYAGGSLYLVIGVLAALQHARAGGPGQVVDAAIVDGTAHLTSVVHGMMAAGGWRDQ
                     RGTNLLDGGSPFYGTYETADGGYMAVGPLERKFYNEFIELLGIADQAPARDDFDSWAEL
                     RAAIADRFKQRTREEWTAVFGTSDACVAPVLSLREAPAHPQLAARSTFVDHGGITQPAP
                     APRFSATPGAVRRVPKGPGAETAEVARDWGVTSLLGGNPS"
     gene            17840..19054
                     /locus_tag="BV401_RS35470"
                     /old_locus_tag="BV401_35540"
     CDS             17840..19054
                     /EC_number="2.3.1.9"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1124: acetyl-CoA acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018513291.1"
                     /locus_tag="BV401_RS35470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_35540"
                     /product="acetyl-CoA C-acetyltransferase"
                     /protein_id="WP_069872435.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 3.2e-05, bitscore:
                     22.5, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTEAYVYDAIRTPRGRGKADGALHGTKPVDLVVGLIHEIRRRFP
                     ELDPAAIDDVVLGVVSPLGDQGSDIAKIAAIAAGLPDTVAGVQENRFCASGLEAVNLAA
                     AKVRSGWEDLVLAGGVESMSRVKMGSDGGAWSADPMTNYETGFVPQGIGADLIATIGGF
                     SRHDVDSYAALSHERAARAWKEGHFDRSVVPVRDRSGLTVLDRDEHIRPGTTPETLAGL
                     KPSFATIGEAGGFDAVALQRYHWVEAIDHVHHAGNSSGMVDGAALVAIGNRETGERFGL
                     TPRARIVSAAVSGADPTIMLTGPAPATRKALTKAGLTIDDIDLVEINEAFAAVVLRFVD
                     DMGLSLDKVNVNGGAIAMGHPLGATGAMILGTVIDELERRDGRFGLVTLCVGGGMGIAT
                     VVERI"
     misc_feature    complement(19229..19244)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.32"
                     /tool="antismash"
     misc_feature    complement(19976..19991)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.75"
                     /tool="antismash"
ORIGIN
        1 atggtcgtcg atccgcagcg tccccgagcg gccgccgctc gtccagtcca gctccaggta
       61 ccagctacag tcacagcccg ccgtccgggc gttgaccagc agcacctcag gatccgaggc
      121 cgagacgcga taggggaagc tgacggcggg gatgggcttg cccgcgtcat tgccgtcggt
      181 ggggcgggcc agcggacggg aggcgtccag gttcaccgag aaggcgcgcg gggtgaggga
      241 acccccacag ccgttgtcca tggcgaacga cgaccacgcg agcggggtgc ggcggcccac
      301 gacccgtacg tgcagggcct ggagcaccac ggccgacgag gcgcggccct gcaccgtgac
      361 ctccacgttg gtggtcccgc cgtgtacggc gccatgcgcg gcggcccagg tcggggcgtc
      421 ctgctcggtg ggcggcgggg ccacctcgga cgggggccgg tcgatgacat agcggtggcc
      481 gcagccgttc tcccagacat gggaacgggt ggagagggtc agcggggccc gggtggagcc
      541 gccgtgatcc ggccccttgg tggcgccggg cgtgggcgag ccggaggcgg cccccttggc
      601 tttccgttcc ttgtcgggtt cgcccttgcc gtcaccgcgc ggtgcgccgg acgcgtcatc
      661 cccgtccgtc ttctgacggt ccagatgtcc tcgggcggtc ggtccggcgg atggtgtgga
      721 ggacggggcg gtggagggag gcgtggccgc ggtgtccttc cggccgtcct cgccgggcgg
      781 ccgtacctcg accgcggtga cggcgagcac gacgacggcg gcggccccgg ccagtaacgc
      841 ccacggccgc cgtccgcgtg acccggcggc gctgcccccg ccgcttcccg acaccgcccg
      901 caaccgccgc cgcctggcgg ccgtgtcggg gggtgcggtg ggcggttggg cctgcccggc
      961 ggtgggtggt tgggcctgcc tgggggtggg tggttgggcc tgcccggggg ccgacgcgga
     1021 cggggtccgg ccgacgtcgg gccgttcggt ggcgtccgcg cccgggtgcg ggtttccgtc
     1081 ccgctgtgcg gccccgcgcc ggcgcgcggt gtcatggccg tgcgccgact ggtccgggcc
     1141 ggtgtcgtcc gcggtgtcgc cttcggcgcg ggggccggtg tcgcctggtg aggaggcggg
     1201 cgttacggcc gggtgggcgc cgggcggcga cgtggccgtc ggcgcgtcgg ccgaggcggc
     1261 ggcgtcgtgt cgttcatcgg ctgccgcgct aggccgggcg tcgcgggagc gcccatccgc
     1321 ctgctccggc ccggcgctgt ctccggccgg gccagtggcc gtggccgccg tcgggggcgg
     1381 gtctgtgacc gggctcgggc cggatgcggt ggcggtggcc gctgtcggtg gcgggtccgc
     1441 caccgggctc gggcggccgg acgtggtggc gcgctcctgg tggcggtcgg cggcgccttc
     1501 gcgtgtgtcg gcctcgcccc cgcgcgaggc cgacggcgtg gcgcccggtg tgctctcccg
     1561 cgcgcggcgt cttgaggctt ccgcgacgat ccagcggcgg tggagggcga ccagctcctc
     1621 cggggtggcg ccgcacagcc gggcgaagcg ctcgacgggg gcgtagtccg ccggtaccgc
     1681 gtcgccgttg cagtagcggt gcagcgtgga cgtgctgacg tgcatgcgtg tggccagcga
     1741 accgtaactg cggcccgagc gctccttcag agcccgcaga ctctcggcga agtcctcgac
     1801 cgccctggcg ttccccacgc caccaccccc caatatcggc cccggcaccg cgacatgtcc
     1861 cgtgggcgtc ccacgcgcgc gttccagggt gttgtcatac ccccaagtca gcgtacgtgc
     1921 aggcgttcca gcgtcccgga tgccccgccg gtcgtagcgg ccacggccag gtggcgcaca
     1981 cgcttgtcct gtcgtcgcgg cctcctggtg cggcggcgac acgctgagat cctgagatcg
     2041 ggaagagacg aggaaccacc tcatgcgcaa gcccttgcac tcattccgcg gcgccgcgct
     2101 cggcgccgtg gccgcggccg ccgtcgtggc cgtggccggg atcgggccgg cccaggccca
     2161 tactccgtcg gcgggggccg gggcggaggc accggcggcc gtgccccagc gcacccccgc
     2221 ccacctcgtg ccgagggagc ttccgccgca tccgagttcg gactggtacg ccggtgatgt
     2281 cacccgtggc ctgcccgaga cccctccgtt ctgcgtggag aagaccctgc cgtcggccgg
     2341 ggcgacccac cgcaccttct ggaccgagta cgacaccggc gccacgcaga tcgtggtcag
     2401 gaccggcacg gtggacgcgg cccgcaagct cgccgccgcg accgagaaga ggatccgcgc
     2461 ctgcgccgcc gactggcagg gcgactatcc gcagggcacc gcctcttggc gggactacgg
     2521 cgcgctgacg gccgaggacg gcgcccatgt ctacggcgtc cacacctcgt acccggactc
     2581 ggagcccggc atccacctct tcggggtggg acgcgacggc cggaccgtca ccgtcgtgtc
     2641 gtggggcgag atgggcggct acgagcaggc gccgttggcc gacttcaagc ggaccaccac
     2701 caccgcggtg gtcaagctgt accacccgtg agcgggggct gacgggggga tgaccgggcc
     2761 ctgacggggg ttgggcccga gggggacgcg gcccgagggg ggccgacggg ggacggggga
     2821 ggggaccggt ggcggccacg cgtacacacg ggggtacgcg tcgccgccac cttcccgtgt
     2881 tcctgggaga tgacgccccg atggacaccc ggccccggag aggtgatgtg ttccggcggc
     2941 agccagcacc cggtgccgga gggtcgatca tgggggcgcg tggccgatag ggtcgaggta
     3001 cgcccgcccc accggacgcc cgaccgtcgg aggtttccca tgccgaacgg ctcgctctcc
     3061 cttgccgcct cgctctacct gctctcctac gaccccgaga ccggccggcc caccgccgct
     3121 cacaccgcac tcctcgtacg cgccgcagcc ctcaccgagc tcgtccagcg gggcatgctc
     3181 accgacgccg acggctgccc atgcccggtg gccgacgccg ccaccgggga tcgtgcgctc
     3241 gacgggctgc tggagctgat cggcgaatcc cggccgcgca gctggcagat ctgggtgggg
     3301 catcagccgc ggctgaccga gcacgcggtc cgcgaccaga tggtggcggc cggttatctg
     3361 cgggcgaagg ggaagcggat gctggggctg ttcccggcca gggagtacac gctggaacgg
     3421 cccgagccgg tggtcgggat gcgggatgac gtggtgcgcg tactgcacgg tgaacagccg
     3481 gcggccgaag tctccgaacg ggacgcggcg ttggtcaccc tggcggccgc gggtgagctg
     3541 aggaccgtcg tgacggccac ggacgccaag gtccgcaagc gccggatcct ggcactgggg
     3601 gagcgctgcg ggggcatggg cccggtgctg gagaaggtga tcgcccaggt gcgtacggcg
     3661 ctcgccgccg ccgtcgccac ggccatgctg gcggcgacca cggccgtgac cgccacctga
     3721 ccccgcaccg cgggggacgg gcccaggcgc ccgtaccgac tcaggcgtcc ctcagcagcg
     3781 acgccagccc ctggtccagg tcgagctccc cggcctcgtt gccctcgggg acgacggcgt
     3841 acgagcggcc gaggaatctg cggaggtcgg cggtgtcgaa ctggaccatg gccatgccct
     3901 cgggggcgtg gaactccagg accgtccgcc gcgatccgca cggccacatc tgtacgtccc
     3961 cgctgcccgc cgggccgcgc agcccggccg cgagcagctc ccgcccgaac gtccactcca
     4021 cctcggagcc gtcgagggac gcggagggcg gaaaggagac gcggacggcg aacgggtcgt
     4081 cccgctcgta gcgcaggcag gccgggatcg cgcgtgactc gggcgtcgac gcgatgagct
     4141 gtgcctggac ggcttggtcg atgacagtgg tcacgtcggg ctcccttgcg ataggtgcgg
     4201 ggcgcgtcgc ccttcgaccg ttaagacgtt tgggcgctca gggcagtgca cccgctttcg
     4261 acgtgacgtg cgtcacgact gatttttcga ggggacatag ggcatttagg cttgccaatc
     4321 catgcaaggt ctcggggcgc cgtgcggagc tgttacagaa cgtcggtagt gacgaggcac
     4381 ccaccccagg ggttgttcca ccatgaccga aggtcacgcg gcgctcgacg cggccgccta
     4441 cgcgagaatc tatgaagccg aatatccgcg tttgtgcgga tatgcccgaa cgctcaccgg
     4501 caacccctgg gttgcgggcg atctggtggc cgaggcgcac tacagcgtgt ggcgccggct
     4561 gcgcgccggg caccccctcg gtgccgacgc catcccggat gagctgacga gcgccgtaag
     4621 ggcgctctcg gccggggcgg ggggctgggg cccggcgcag caggcgtcgt atctcgaacc
     4681 gctggtgcgg gttctcgatg agctgccgca gcgctggatc aaggtgctgt ggctcgccga
     4741 ggtggacggg ctcccgccgg aggaggtggc gcggcgggcc gggatgaccg acgacgacgc
     4801 ggcggccctg gtggagcgcg tccgggagag cgtgcgccag gagttcctgc gcgcccagcc
     4861 cggctatccg gcgagcgccg cgtgcggtgc gcactgggag cggctgcccg accatgtgcg
     4921 gggcgcggac tccccgcacc aggccgagga gatcgccgtg cacatcgacg gctgccggga
     4981 ctgccggggc cgcatggagc agctggtggc ggccgacgac cgactgcccg cactggtcgg
     5041 cccggcgctg ctcgacctgt acgaccggga catggcgcgc ttcctggcgc cgctggtggc
     5101 tgcgggtggg gcggctgccg tggcggccgc cggagcgggc gccatgacat ccggcggtgc
     5161 gcatgcggcc ccctcgaacg ggccgctggt ctcgtcccgc cgctccatgc agcacctcgt
     5221 ccgggggcgg gtgcgccagg cggggccggt ggcggtggcg gcggccgcgg gtggggtgct
     5281 gctggtcgcg ggggcggcgg tcatgacggg gctggcgctg acggacggcg gctcggcgga
     5341 ggcgcagcag ccggcgacgg cgtcgacgcc gtccatatcg gacacctccg actcttcttc
     5401 cgcttcttcc ggctcctcgt cggcttcggg tacgtccggg gcgtcgcggc actcggacgg
     5461 gccgcgggcg ggcgttccgg gggaggcgtc ccggaaccgg caatccacgt cgggcgtgcc
     5521 cgcggggcac tccccggcgg atgtgccgtc cagcgccgta tcgccctcgc ggaaggcgcc
     5581 gtcgtcctct tcctccgctt cgccctcgtc gcggccgtct tcgccttcct catccgcttc
     5641 ctcctccgcg tcgagcggcc cgtcgcaccg gccgacgggg aagccgaccg gcacaccgac
     5701 cggggagccg acgggcggcg ggacggcgga cccgggggac accccgagcg ggcggccgac
     5761 gcagcgcccc acggacgagt cgacgcagcg gcccacgacc aagccgaccg actccggctc
     5821 tgcctctggc tccgcctccg gctccggtga ctcccgggac tgcgtctcgc tggtggtgcg
     5881 gctctgcgtg tcccgctagg gcgggcgggg gtgcccgccg ggccctgacg cctgcggcga
     5941 gccgttcccc tccccgcccc ttcccgaacc ggggctccgc cccggacccc gagcggggct
     6001 ccgccccaga ccccgaaacc ggagctccgc cccagacccc gggcggggct tggccccaga
     6061 cttcgggccg gggcttcgcc ccagatcccg ggtggggttt tcgccccaga ctctgggcgg
     6121 ggggtttcgt ctcggccctg ggtgggggtt gcgcctccga ttctgggtgg gggctccgtc
     6181 ccagacctcg gaccggggct ccgtcccgga gcccgggccg gggcttcggc ccttcccgcc
     6241 gcatggccat gcggctccgc cgcgcggtgg ggcttcgccc caagcccggg gtccaggggc
     6301 ggagcccctg gtatcgggaa ggggcgggga gggggaaacg ccccaccaga cgccccgtag
     6361 cgcgtgcggc caccagggct caattacaga acgtgtcaag cgtgttgccc tccggagcgt
     6421 aagctcaaaa caagccagcg gtcccagccg gacagcggga ccaggaggga tggaccaatg
     6481 acgttccagc cgcgcgaact cttccccgac cgctccgcac gcgacctgtt cggcgcggag
     6541 atccgccgcc accgcgagaa ggcggacatg tcgctgcggc ggctgtccga ggtgctgaac
     6601 tacagcaagt cccacctcgc gcggatcgag gcggcggagt cgctgccgta cgacgaccta
     6661 ccggcgaaac tggacgcgtg cttcggggcg gatgggttat tcgcgaggct gtacgcgctg
     6721 gcgaagaacg agccgttccc gggcaagtac cggcgaatga tcgagttgga gagccaggcg
     6781 gtcatcatcg agcagtacgt gggcgccacc atgccgggcc tgcttcagac tccggacacg
     6841 gcagagtgct ggctgcggtg cggccgcccg cacgctcctg acgcggagat cgaggcaatg
     6901 gtgaaagccc gcatcgaccg acagtcgttg ctggaccgcc ccaagccgcc gcgctgttgg
     6961 ttcatcctcg aggaggcggt actgcgccgt cccgtcgggg gtcttcaggt gatgcatcat
     7021 cagttgacct ccctgatcga gcgtggtgca cagccgcacg tcaccctcca ggtgctgccc
     7081 ttcacggctg gcgagcacgc ggagaccggg ggttctctga ctctcttcac ggtcccccat
     7141 ggggcgttgg tggcgtatga cgagagcagc cagtccggga ccatcatcga ggaccaggag
     7201 actgttgcgc ggcgcaggga gaactacgat ctgcttaggg ccatggccct ctcgccccgc
     7261 gactccgagg cgatgatccg agccgtgatg aaggactgga gcccatgcca accaccccgg
     7321 gcctgagtgt tgccacgtgg cgcaagagca gttacagcaa tcccgacggc ggcaactgcg
     7381 tggaggtcgc ggacaacctc cccggtgtca tccccgtccg cgactccaag aaccccgacg
     7441 gccccgccct catattcgct gccggagcat gggccacgtt catcgcaagc ctcaagacgg
     7501 gctgactcat gccaaccacc ccggacctga gcgctgccgc gtggcgcaag agcagctaca
     7561 gcaacggcga cggcggcgat tgcgtcgagg tcgccgacaa cttcccgggc ggcgtcgtcc
     7621 cggtccgtga ctccaagaac cccgatggcc ccgccatccc gttccccacc aaatcgtggg
     7681 tcgcgttcat agcctctctc aaggcatgag cgatcgccgc atgctggaat acgaacggtt
     7741 tcatgaccat gcaccgtagc gtccaggcgg tgaacaggcg tccatagcag ccgagttggg
     7801 cagggtccgg ccggggccat ccggatttgg cggcggaggt gagccatgag gaaggcacgt
     7861 gcgggtcttt cggcgttcga agcgagagca ggagaggccg cgcggaccct gctgcacaac
     7921 cagggctacg acggcgggtg gggtctcacg ctcacatcgg tgtcgtcgat cgtcaacacg
     7981 agcgaggtcc ttccgatcct gcgggccgcc gggctcgcag ggcagccggt gcgcaaggca
     8041 ctcgactttc tgaccggcgc cattccggag cactgccgcc cccgtcacaa gggcggccgt
     8101 ggtgagcaca cccgcttcgt cgccttcggc ctgaccggac tgctgtcgca cccgcgtttc
     8161 ttccaccacg acggtgtcgt ggaggccgcg gtctggtgcg tcggctggct cgaggaccat
     8221 cgcgttgacc acggctggcc cgaggtactc ggtctcgacg acacctcgct gcaccagacc
     8281 gccctcgccg tgcatgggct cgcccagctc agggacaccc tccacgagct cggcccgggt
     8341 ttcgtcctgc ccggtggggc ggacaccacg agcctgctgg ggcgagtcga gccactgatc
     8401 gaccacggtg tccatggtct tctctaccac cgccggtcca gcggcgcctg gggttggcgc
     8461 acctacgtga ataccgaccc gagcccgagc aagaccgcgc tgtgcctgct ggcgctctcc
     8521 gcagttgcct ccggggccgg tcccggaggc gaaccggcct accgggacgc gccccgggac
     8581 gccggaggcg tccacggccc ggtgcagaag aagcggctga ccgaggcggt cgtcgaggcc
     8641 gggcagtggc tgctgcgcaa ccaccaccgc tgggagacct tcgtcgagga cgataaggac
     8701 gtacagggca ccgcgtggga gcatatggcg tacgcgctgt gcacccaggc cgtcatccgt
     8761 gctggcgcca acccacgcga tccccggctg tccacggcgt ggcggctgat gaacgacctg
     8821 tgggagcccg aggccgggat gtggaacgaa cccggcgcct ttgtcaagcg cgccactatc
     8881 cgcgcggcgt actacaccgt ctcggcctac caggaggccc tcggccgtct cgcccgaatc
     8941 ggcatcggcg aggaaatcag ggccggtaac agcgacattg cggtggagat ccccctcagg
     9001 ggcgccgagc ttgccgctgg gcacacggtc ctgctcacca caccggacag cgacggcccg
     9061 gtggcatgtc agctctcgga gcggctgttc gacctggcga aggtcgtgca cgacggtcct
     9121 ggcgagggca tgtcgaccga gcagatcgcc caggccctgt tcgttgcccc gtcctcggtt
     9181 cccaagtacg tccagcgcct gaaccaggcg gtgtccgccg ccctcggcgg caccccggcc
     9241 cggctgctga tggccgacac cgtgaacggg tccggcggct acgcctgggc ccgctcggag
     9301 gcgaccgggt agttcagcag ggcgaagcgt gccagggagc ggacctgctc gaaggtcggc
     9361 aactgctcca ggtcctccag gctgaaccac ccagccccgt gcacctcctc catctgcgcc
     9421 tccacggcct gctcaccggt gcctgcctgg cggcggacgt agaagaactg gaccagggcg
     9481 gggatggcga acccttcccg ctcgatgtcc acgtagaacg gcaccggctc gggggtggcg
     9541 ttgtcgtcgg ccgggtggat ggcgggctga ctggagatcg cctccaccag caggccggtc
     9601 tcctctttga attcccgcac ggccgttccg gcgaacgact cgccaggctc gatgtgcccg
     9661 ccaggcggga cccacttgtc gaagcggttg tggtggacga gcagcacctt gccgcgctcg
     9721 acgaggtagc ccgagcagat atacaccaga ccgacgtcgc gggcggtccg gccgtcgtga
     9781 atcagaatcg agcgaggcac gctcgccacg atagcccacc ggccctttcc tgaactcgcc
     9841 agcagagcag gggcttcggg tgccggatga catgtcatcg gcgatgacat cgcaatgtca
     9901 tcgcatacac gtcatgacag gccggaaggt ggacgcgtgc cccgccgctg ccgatcggct
     9961 gcgtgggcga aggccctgtt cggtgaggga aaggaccgtg atgcgcaccc gcatctccgg
    10021 ctggcgtgcc cgctacgatc agtggttcac ggtcccgcag accgtggttg ttcagcccac
    10081 gacctggtgc aatctcgact gccactactg ctacctgcct ttccgcaagc tcaggcacca
    10141 catgcgcccc gatgtcgccg ccgccctggc gatgtcggtc gctcagctca cggccagcgg
    10201 cagtccgccc atcgggatcg tctggcacgg cggggagccc ctcgcgctcg gcccgcagaa
    10261 gttcagggcg ctgctcgctc ccttcgagga tctgcgctgc gcgggccgtg tccaccacta
    10321 cgtgcagacc aacgccaccc tgatcaccga cacctggtgc gagctgctga ccgcatacga
    10381 catccgcgtg ggcgtgagca tcgacggccc gaccgcgttg aacaccgagc gggtcgacct
    10441 gcgcggcaag cctgccttcg accggattct ccacggcgtc cggcgactgc gtgagcacgg
    10501 catcccgttc tccgtgattt cggtcgtcgc cacgcagtcc atcactcagc ccgaagagct
    10561 gctgggattc ctggcgaagc tgggctgcga ctcggcgggg ttcaacatcg aggaggtcga
    10621 gggcgtcaat accgaccggc aggcgcccac gcccgcgcag gccgaggagt tctggcgccg
    10681 caccctcatc tggacccgct cccacggcga ccgcctgaag gtgagggaac tcgaacgcct
    10741 cgccgagtac ctgcacctga tccgcaccgg acagcgcgtg gcgtgggatg agcggcgcct
    10801 cgatccaatc cccaccgtct ccgtcgccgg tgatgtggtg ctgctctccc cggagcttgc
    10861 ggacaccacc gaccctgtct acgacgactt ccgggccggc aacatcctcc accagcccct
    10921 gcccatgatc ctgagcggcg cgcaccgact ccgctacgtc cgagacttcc tcaccggcct
    10981 ggaccgctgc cgggccgggt gcgcgttttt cgacttctgt cgcggcgccc aggccgccaa
    11041 ccgctacttc gagaacggca gcctgaagtc caccgagacc aactactgcc aggtctcccg
    11101 gcaggccctg gtcacggccc tgtccaccct cgcaaccaag gagaaagggc gagcaacatg
    11161 acactcctcg acggattggc cacttccgac gccccggtcg tgatggactt gatctccgcc
    11221 cacgtcgctc cggcgcccgt gaccattcgg gcggcgtggg acaaccggcc tacgtgggac
    11281 aactggcgga agagccccgc acccttcgac aatcggccca cgtgggacaa ctggaacaag
    11341 aagaagtagc ctccgtcggg cggcgcgccc gcaccagggc gcaccggcgg tgcctcaccg
    11401 ggcccacctc atgggaaggc atctcaatgg gaacccgcac gatccgccgc acgagcgtca
    11461 ccctgccctc gctggacgag cccggcctgt acctgtccca cgtgacctcg ctcgaaggcg
    11521 gtcgtggccg ggtcgcggag ttccactacg gcgacgcgga tctgcgcgcg ctggacctgg
    11581 ccgacacgca cctgatcgat gggcggatct ccgggctcaa gacccagcgc gcccggctgg
    11641 agaagctccg cgtcgactct gtggaattca ccggctgcga cctgtcctcc ctgcgctgga
    11701 ccgacagcaa ggtcacccgc gccgtcttcc gagactgcaa gctgatgggc gccatgctgg
    11761 aggacgtcac cctcgacgac gtcctgttcg agaactgcaa gctcgactac agcaccttca
    11821 cccgcgtccg ggccgtcgga cccctgatct tctcccagtg ctccctgcgc gagaccatgt
    11881 tcgacgcggc cgacctgagc acagctgcgt tcgagggctg cgatctacgg cttgccgagt
    11941 tcggcggtgg cacgtaccgc cacctggacc tgcgcggcaa cgacctctcc cagctccgtg
    12001 gcctcgcctc actcaagcag gtgatcatcg accatggaca gaccccgcag ctggccgagg
    12061 ctctcgccgc agaactcgac gtcacctacg gcgaagacct cgacgacaag tagtccctca
    12121 tccgacggac cgatggcgtt ccagttccag ccgcgcgaac ttttccctga ccgctccgca
    12181 cgcgacctgt tcggcgcgga cgatccccgt gccgacctta cggccgctgc tagcggtatt
    12241 ccgtgagtgc cggggccgta cgggtggcca ggaactcggt gatggtgtat tcgccgacgc
    12301 ccgcgacgat gaaggggtcg ctcgccacca tctcctcgat cttcgcccgg tcgtcgccga
    12361 gcgccaggat caccccgccg tcgcgggggt tcttggggcc ggaggcgagg aaggcgccgt
    12421 tcgcgaagtg gtcgtccacc cagacgaggt gttcggggag ggcggcctcg acgcggtctg
    12481 ccgaggcggt gtacgtgatc tccagtacga acatgacagc caggctagta acgtgagcca
    12541 cacgatgacc agcgctgtcg atccacgata tgagctgccc cgcgactggc cctcgaccga
    12601 ggccgaggcg atcgccgtcc aggagcggac gcgggcgtcc gtggtcgtcg gcggggaggt
    12661 gcccgcgccg gacaccggcc ccggtgcggt cgtcggggtg gacgtggcgt acgacgacga
    12721 gcgcgacctg gtcgcggccg ccgccgtcgc gctggacgcc cgcggcctcg acatcgtcgc
    12781 ggaggcgacc gcggtcggcc gggtcacctt cccgtacgtc cccgggctgc tggcgttccg
    12841 tgagatcccg gccgtcctcg acgcgctggg cgacctcgac cggcggctcg gccgccgccc
    12901 cgacctggtg gtgtgcgacg gctacggcct cgcccacccc cgccgattcg ggctggccag
    12961 ccatctgggg gtgctcaccg ggctgcccac catcggcgtc gccaagaacc tcttcggctt
    13021 ccgccacgcc gacccggggc cgcgccgcgg cgactgggcg ccgctgctcg acggggagga
    13081 ggaggtcggc cgggcgctgc gcacccgcga cggtgtgaag ccgctcttcg tctccgtcgg
    13141 ccatcgggtg accatcacgg acgcctgcgc gtacaccctg cacctggccc gcgacttccg
    13201 gcagcccgag acgacacggc gcgcggacgc gctgtgccgc cgggccttga aagccgccac
    13261 gctctgaacg cggtgtggtg agtccggcac tccgaacgtg gcggctgcgc actcggtact
    13321 ccgggcgcgg tgccggggga acccctgtac cccccggcgc cgccccgccc ccggggtgcc
    13381 ggacgcctca gacccgccgc gtctcggcca ggaagcagcc gaactcgacg gcgcgcacat
    13441 gcaccgccgc cacccgcggg tccgcgtacc actcggccag cccctcctcg atcgtcggcc
    13501 cgccgtcgtc cagcagccgg ccgccgagga tgttgccctc ggcggagtac gcccgcagca
    13561 cccgccgccg gccccggatg ccctccgcga tgccggggcc ggtccagccg tcgcactcct
    13621 cggggtggat gaagaccggg ccgacctcgt cgtacgggcc gggtccggca cccgtctcgc
    13681 gcgcccagcg gcgcagcggg gcgtaggaga cgagcgcgat ggtctcgtac gggcggctcc
    13741 ggcccaggca gcagcgcagc gggctgccgc cctcctcgtc atccaccacc aggcgcggcg
    13801 ggtgccccgc gtcgtcggtg gtgcgcagca gcttcagcgc ctcgggcgcg atggcccgca
    13861 tctcgtagat ctcgccgtgg ttctcgctca tgcgttcaag gctggcgggt gggggcacgg
    13921 agcgctggcg ggattcggac ggggcgctga ggcggggatg tacttgacag ggcgatggcg
    13981 ctccgtcaga ttcgggccga aacataggac gtcccacgtc cgtattgtcc tgctattcag
    14041 aaggctgggt gtcgatgagt cttccggctc cccttaccgg tgtcgttccg cccctgtgca
    14101 ccccgttcac gcccacgggc gaggtcgaca cccgttctct cgccgcgctc gccgagcggc
    14161 tgatcgacgc gggggtgagc gcgctgttcg cgctcggctc cagcggcgag gccgcctatc
    14221 tgggtgacgg cggccgccgt acggcccttg aggcggtcat cgaggccgcg gacggccggg
    14281 tgcccgtgct cgcgggggcg atcgacatga cgaccgcgcg ggtgctggac catgcccgta
    14341 cggcggcgga gttgggcgcg gacgcggtcg tggccaccgc gccgttctac acccgcaccc
    14401 accccgtgga gatcgccgac cacttccggc ggctgcgcca tggcgtggac ctgccgctgt
    14461 tcgcgtatga catcccggtc tccgtccact ccaagctgac gccctcgatc ctgctgccgc
    14521 tggccgccga tgccacgctg gccggggtca aggacagcag cggggacgac ggggcgctgc
    14581 ggcggctgct ggtcgaggtc cgccggcgcg gtctcatcga ctccttcacc gtgctcaccg
    14641 gctccgaact ttcggtggac ggcgccctgc tggcgggggc ccatggggtc gtcccggggc
    14701 tggccaatgt cgacccggcc ggtttcgtcc ggctgtacga gcatgcgcgc gcggggcgct
    14761 gggagcgtgc cgccgccgaa caggaccggc tggccgcgct gttcgccatc accgccgccg
    14821 gggatccggc cctgatgggc ggcagctcgt cggggctggg cggcttcaag gccgcgctgc
    14881 ggctgctcgg cgtgatcgat tgcccggaca ccgccgcgcc ccaggtgccg ctgggcgggg
    14941 cggccgtgaa gaccgtacgt caactcctgg aggagggagg gctgttgccg tgaccgaagc
    15001 cgccaaggtg ccctggtacc gagaggtctt acctggccag tggaagtccc tgttcgccgc
    15061 ctggatcggc tatctgctcg acggtttcga ctttgtgctg atcacgctcg tcctgaccga
    15121 gatagccgac gagttcgacc tgagcacggc ctcggccgcg agcctggtct cgggcgcctt
    15181 catcacccgc tggctcggcg gggcgctgct gggcgcgctg ggcgaccgct acggccgtaa
    15241 ggccgccatg gtcgtcagca ttctgctcta ctcgctgggc accttcgcct gcgggttcgc
    15301 ctggaactac ctcagcctgt tcaccgctcg cctagtgatt ggcatgggca tggcgggtga
    15361 gtacagcgcc agtgccacct atgtcctgga gagctggccc gcacggctgc gcaaccgcgc
    15421 ctccggcttc ctcatctcgg gctactcggg cggcaccatc atcgcctccg agctctacaa
    15481 gtgggtggtg ccccactggg gctggcgctg gatgttctgg atcggcgtgc tgccggtgct
    15541 ggtcgcgctg tgggtgcggc gcgcgctccc ggaggccggg gactggcacg aggaggtggc
    15601 ggcggcacgg gcgcggccca accccttccg gccgctgttc gccggacgca cccgcgcggg
    15661 cgtcaacacg gcgctgaccg tggccgcgag cgtcgcgctg ttcctggtct tcaccccgcc
    15721 gggcgcgggc tggcgctggc cgctgtcgat cctggcggcc gggtgtctgg tcgccttcgc
    15781 ggcccagctc ggcggacggc gccgctggcc gctgtacgtg ggcctgatgt gcacggtctt
    15841 ctgcgccttc ctctacagct ggcccatcca ggcgctgctg cccacctatc tgaaggagca
    15901 gctcggctac accccctccg aggtcaccga tgtgatgttc tacgccgggt tcggcacgat
    15961 ggccggctgc tgtcttgcgg gtttcgtggg cgactggctc ggcacccggc gcgcctacgc
    16021 cttcaccctg ctggcctcgc tggccttcgt cttcccggtg ttcgcggtgc gcgacaccct
    16081 ggtcgggctc ggagtgctgc tgttcttcct gctcgcgctg agccagggga tctccggcat
    16141 cctgccgaag tacatcgcgg gtcacttccc gaccgagagc cgggcggcct ccctgggctt
    16201 cgtctacaac accggggcgc tcggcggcgc ggtggcgccg gtgcttggcg cccatctggc
    16261 cgagggcatg tccctcgggc gggcgctggc ggtgctcacc ttcgggctga cgctcgtggt
    16321 catcgtgctg gtcggcaccg atgtgccccg caggctcggg cggctgaccg atccggcggg
    16381 cgaccaggac catctcctgc ccggacagcc gctgtcgacg gcgaggcccg gcgtggacac
    16441 gacctgaccc cgaacgccgg tcggcgccac acccggcccg ccatgccact gcgggggccg
    16501 aacccccttt ccggtcacgg cgtttggttg tccacagact cctgggaggg cttgtggaat
    16561 gccggacgcg ttcttagcat cggcggtgtt acagcggtgg tgtcacacga ttgggggacg
    16621 ggatgacggt ggctgaggag ggggcggcag gccctctggc cggagtgcgg gtgctggagc
    16681 tcgccggaat cgggccgggt ccgttcgccg ccatggtcct cggcgaccta ggcgccgatg
    16741 tggtccgcgt cgaccggccc ggagggccca ggggcccgcg gatggacccg gacttcgacc
    16801 tcgccaaccg caacaagcgc tcggtgctgc tcgacctcaa atccgaggag aacgtcggcg
    16861 tcgttctcga cctcgtggag cgcgccgaca tcctcatcga gggctaccgc ccgggggtca
    16921 ccgagcggct gggcctgggc ccggacgact gcctggcccg taaccccaag ctggtctacg
    16981 gccggatgac cggctggggg caggagggcc cgctcgccca gtccgccggc catgacatcg
    17041 gctatatcgc cgtcaccggc gccctcagca tgatcggcac gaccgacggc ccgcccatcg
    17101 cccccgccaa cctcctgggg gactacgcgg gaggctcgct ctatctcgtc atcggtgtcc
    17161 tggccgccct tcagcacgcc cgcgcgggcg gccccggcca ggtggtggac gccgcgatcg
    17221 tggacggcac cgcccatctg acctccgtcg tccacgggat gatggccgcc gggggctggc
    17281 gggaccagcg cggcaccaac ctcctcgacg gcggcagccc cttctacggc acctatgaga
    17341 ccgccgatgg cggctatatg gcggtcgggc ccctggagcg caagttctac aacgagttca
    17401 tcgagctgct gggcatcgcc gaccaggccc cggcccgcga tgacttcgac agctgggccg
    17461 agctgcgcgc cgccatcgcc gaccgcttca agcagcgcac ccgcgaggag tggaccgccg
    17521 tcttcggcac ctcggacgcc tgcgtcgccc ccgtcctgtc gctgcgcgag gccccggccc
    17581 atccgcagct cgccgcccgc tccaccttcg tcgaccacgg cggaatcacc cagcccgcgc
    17641 ccgccccgcg cttctccgcc accccgggcg cggtgcgccg cgtgcccaag gggcccgggg
    17701 cggagaccgc cgaggtggcc cgcgactggg gagtcacctc gctcctcggg ggaaacccgt
    17761 catgacctcc cgtccgctcc ccgccggccc gctgagccgt ccccgcccga tccctcccct
    17821 cccctgaaag gccgctgacg tgagcaccga agcgtatgtg tacgacgcca tccgcacccc
    17881 gcgcgggcgc gggaaggccg acggtgccct gcacggcacc aagcccgtcg acctggtggt
    17941 gggcctcatc cacgagatcc ggcggcgctt ccccgagctg gacccggcgg cgatcgacga
    18001 tgtggtcctc ggcgtcgtca gcccactggg cgaccagggc tccgacatcg ccaagatcgc
    18061 ggccatcgcg gccgggctcc cggacacggt cgcgggcgtc caggagaacc gcttctgtgc
    18121 ctcgggcctg gaggccgtca acctggcggc ggccaaggtc cgttccggct gggaggacct
    18181 ggtgctcgcg ggcggggtcg agtcgatgtc acgggtgaag atgggctccg acggcggggc
    18241 ctggtccgcg gacccgatga ccaactacga gaccggcttc gtaccgcagg gcatcggggc
    18301 cgacctcatc gccaccatcg gcggcttcag ccgccatgac gtggacagct acgccgcgct
    18361 ctcccatgag cgggccgcgc gggcctggaa ggaggggcac ttcgaccgct ccgtggtccc
    18421 ggtccgcgac cgcagcgggc tgaccgtcct cgaccgcgac gagcacatcc gccccggtac
    18481 cacccccgag accctggcgg gtctgaagcc gtcgttcgcc actatcggcg aggccggagg
    18541 cttcgacgcg gtggcgctcc agaggtacca ctgggtcgag gcgatcgacc acgtccacca
    18601 cgcgggcaac tcctcgggca tggtggacgg cgccgccctg gtcgccatcg gcaaccgcga
    18661 gaccggcgag cgcttcgggc tgaccccgcg cgcccggatc gtctccgccg ccgtctccgg
    18721 cgccgacccc accatcatgc tcaccggccc ggctcccgcc acccgtaagg cgctcaccaa
    18781 ggccgggctg accatcgacg acatcgatct ggtcgagatc aacgaggcgt tcgcggcggt
    18841 ggtgctgcgc ttcgtggacg acatggggct gagcctggac aaggtcaatg tcaacggcgg
    18901 cgcgatcgcg atgggccatc cgctgggcgc caccggcgcg atgatcctcg gcacggtgat
    18961 cgacgagctg gagcggcggg acgggcggtt cgggctggtg acgctgtgcg tgggaggcgg
    19021 gatgggcatc gcgacggtgg tcgagcggat ctagccgccg aggccgccgc tcggctcgcc
    19081 tctccgcccc gtccctttct gccccgcccc ccgcccccgc cccacgtccc ttcgccctgg
    19141 agacctcaga tgacccaccc caccacggcc tcgaccatcc gctgggagca ggacgacgaa
    19201 ggcgtcgtca ccctggtgct cgacgacccc gaccagtccg ccaacaccat gaacgccgcg
    19261 ttcatcgact ccctcgacgc gatcgccgac cgcgccgagg ccgagcgcga atcgatcagc
    19321 ggcatcatcg tcacctccgc caagaagacc ttcttcgccg gtggcgatct caacgacctc
    19381 atcgaggtcg ggcccgacca ggcccaggag gtctacgaca agaacctccg catcaagcgc
    19441 gcgctgcgcc gcatcgagac gctcggcagg cccgtggtcg ccgcgatcaa cggcgcagcg
    19501 ctcggcggcg ggctggagat cgcgctcacc tgccaccacc gcatcgccct cgacgccccc
    19561 ggatcccgta tcggcttccc cgaggtcacc ctgggcctgc tcccgggcag cgggggcgtc
    19621 gcccgtaccg tacggctgct cggcgtcacc gacgcgctgc tcaagtggct gctccagggc
    19681 atgcgctaca gcccccggcg cgcccaggag gcggggctgg tgcacgaggt cgccaccacc
    19741 cgcgaggaga tgctgaccct ggcccgcgcg ttcatcgccg cccaccccga gtcggcacag
    19801 ccctgggacg agaaggacta ccggatcccg ggcggcaccc cggcgcagcc gaagttcgcc
    19861 gtcaatctgc ccgccttccc cgccaatctg cgcaagcagc tgaacggcgc gccctatccg
    19921 gcgcagcgca atatcctggc cgccgccgtc gaggggtccc aggtggactt cgagaccgca
    19981 cagaccatcg aggcccggta cttcaccgag ctggtcgtcg gccagaccgc caagaacatg
    20041 attcaggcgt tcttcttcga tctccaggcg gtcaactccg gtgccaaccg cccccagggg
    20101 atcgagcccc agcaggtccg taaggtcgcg gtgctgggcg ccgggatgat gggcgcgggc
    20161 atcgcgtacg cctgcgccaa ggcgggcatc gaggtcgtcc tcaaggatgt gtccgtggag
    20221 gccgccgcca agggcaaggc gtactccgag gggctgctgg ccaaggcgct cgccaagggc
    20281 cggaccaccg aggcgaagcg ggacgggctg ctggcccgga tcaccccgac cgccgacctc
    20341 cgcgacctcg agggctgtga cgcggtcatc gaggcggtct tcgaggatcc ggcgctcaag
    20401 cacaaggtgt tccaggagat cgagggcgtc gtcgccccgg acgccctgct gtgctccaac
    20461 acctccaccc tccccatcac cctgctctcg gagggggtgc agcgcgccga ggacttcatc
    20521 ggactgcact tcttctcgcc cgtggacaag atgccgctgg tcgagatcat caagggcgag
    20581 cgcaccggcg acaaggcgct ggcccgcgcc ttcgatctgg tgcggcagat cagcaagacc
    20641 ccgatcgtgg tcaatgactc ccgcgccttc ttcacctccc gcgtcatcgg ccacttcctc
    20701 aacgagggcg tggcgatggt gggggagggc atcgccccgg cctccgtgga gcaggccgcg
    20761 gcccaggccg gctacccggc caaggtgctc tccctgatgg acgagctgac cctcaccctg
    20821 gcgcgcaaga tccgcgagga gacgcgccgg gcgaccgagg aggcgggcgg cgagtggcgg
    20881 ccgcatccgg ccgacgcggt catcgaccgc atggtggagg agttcgggcg ccccggccgc
    20941 agcggtgggg cgggcttcta cgactacgac gagacgaccg gccggcgcac ccggctgtgg
    21001 ccggggctgc gggagcactt cgcgccgggc gagtccggcg agtccggtgg ttccggtggc
    21061 tccggtggtt ccggtggctc ccgtggtgag ggcacccgga tccccatgga ggacatgaag
    21121 gagcggatgc tcttctgtga ggccatcgac acggtgcggc t
//
