LOCUS       NZ_CP019458            22397 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces autolyticus strain CGMCC0516 chromosome, complete
            genome.
ACCESSION   NZ_CP019458
VERSION     NZ_CP019458.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces autolyticus
  ORGANISM  Streptomyces autolyticus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10029028)
  AUTHORS   Yin,M., Jiang,M., Ren,Z., Dong,Y. and Lu,T.
  TITLE     The complete genome sequence of Streptomyces autolyticus CGMCC 0516,
            the producer of geldanamycin, autolytimycin, reblastatin and
            elaiophylin
  JOURNAL   J Biotechnol 252, 27-31 (2017)
   PUBMED   28472671
REFERENCE   2  (bases 1 to 10029028)
  AUTHORS   Yin,M., Jiang,M. and Lu,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2017) Yunnan University, Yunnan University, 2#
            Cuihu Beilu, Kunming, Yunnan 650091, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Analysis v. 2.3.0
            Genome Coverage                   :: 279x
            Sequencing Technology             :: Illumina; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 03:05:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,227
            CDSs (total)                      :: 8,141
            Genes (coding)                    :: 7,920
            CDSs (with protein)               :: 7,920
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 221
            CDSs (without protein)            :: 221
            Pseudo Genes (ambiguous residues) :: 0 of 221
            Pseudo Genes (frameshifted)       :: 74 of 221
            Pseudo Genes (incomplete)         :: 182 of 221
            Pseudo Genes (internal stop)      :: 9 of 221
            Pseudo Genes (multiple problems)  :: 42 of 221
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:31:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5531568
            Orig. end                         :: 5553965
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP019458.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22397
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="29"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22397
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22397
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12397](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12397)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(1137..1151)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     gene            complement(1654..2430)
                     /locus_tag="BV401_RS22060"
                     /old_locus_tag="BV401_22110"
     CDS             complement(1654..2430)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061810.1"
                     /locus_tag="BV401_RS22060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_22110"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_087684237.1"
                     /transl_table=11
                     /translation="MNRQWRGRRTATVERTGTWHHALALDGVTREYRLGAVALHPIHLT
                     VPRGRFLAVMGPSGCGKSTLLQCAAGLDRPTAGTVRIGGTELSSLNEAALTRLRRERIG
                     FVFQAHHLVPSLTVAENVSLPLMLGGRPVDGRERRALAAVGLGDRGGALPSELSGGQCQ
                     RVAIARALVTSPDIVFADEPTGALDPAAAEEALTLLRQAVDRDGHTVVMVTHDPFAAAW
                     ADEALFLMRGKLVWRQERPEAADIRRVLKDLGGRTA"
     gene            2779..4125
                     /gene="gdhA"
                     /locus_tag="BV401_RS22065"
                     /old_locus_tag="BV401_22115"
     CDS             2779..4125
                     /EC_number="1.4.1.4"
                     /GO_function="GO:0016639 - oxidoreductase activity, acting
                     on the CH-NH2 group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="gdhA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061811.1"
                     /locus_tag="BV401_RS22065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_22115"
                     /product="NADP-specific glutamate dehydrogenase"
                     /protein_id="WP_079258178.1"
                     /transl_table=11
                     /translation="MDVSARIEAVYAQIVHRNPGESEFHQAAREVLPALAPVLGAHPEY
                     VDARIVERLCEPERQLAFRVPWVDDDGEVQVNRGFRVEFSSALGPYKGGLRFHPSVNLG
                     IVKFLGFEQIFKNALTGLAIGGGKGGADFDPKGRSDGEVMRFCQSFMTELHRHLGEHTD
                     VPAGDIGVGAREIGYLFGQYKRLTNRFEAGVLTGKPVGWGGSHARTEATGYGTVHFAQE
                     MLRTRKKDFDGLTVVVSGSGNVALYAIDKVHALGGRVVACSDSSGHVVDPDGIDLALLK
                     EIKEVRRGRIDAYATAKPGAVFSGRGSVFEVPCEVVLPCATQNELTEQCAITLVKNGVL
                     AVAEGANMPCTPAAIEIFREADVLFGPGKAANAGGVATSALEMQQNASRERWTFAQTEA
                     RLAAVMTEVHTLCRTTADRYGCSPDDYALGANAAGFVRVAEAMAAQGIV"
     gene            complement(4202..5317)
                     /locus_tag="BV401_RS22070"
                     /old_locus_tag="BV401_22120"
     CDS             complement(4202..5317)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061812.1"
                     /locus_tag="BV401_RS22070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_22120"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_079258179.1"
                     /transl_table=11
                     /translation="MYPARLRTYDPDQMDGTGLIAPAVPVFIIIGVALLALVTSEGLGW
                     LPMLAVGPALAAAHWGPYGVMRIGLLAVGVGALLGTQGEETLRTQAIMLATPAAVALAS
                     CGASAMRQRREQVLAAVRSVAEAAQNALLTPVPAQVGEFQVAVRYSAAAAEARVGGDLY
                     ALLSTPHGVRLIVGDVRGKGLPAVSTAALVLGVFREAAYDERDLLDVVGRIERSLARNL
                     APDDFVTAVVAGYPSEGRMELVNCGHAPPLLFGESGVSAVEPIRPAPPLGLASLGGELP
                     SLQVVPFIEGDQLLLYTDGVIEARDRGREYFPLLERVPRHICDEPSRTLASLHAELLSH
                     VGGRLHDDAALLLLRKPVLGAMRGAAEMPSM"
     misc_feature    5408..5422
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.14"
                     /tool="antismash"
     misc_feature    complement(5410..5424)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.98"
                     /tool="antismash"
     gene            complement(5413..6192)
                     /locus_tag="BV401_RS22075"
                     /old_locus_tag="BV401_22125"
     CDS             complement(5413..6192)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010043927.1"
                     /locus_tag="BV401_RS22075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_22125"
                     /product="IclR family transcriptional regulator C-terminal
                     domain-containing protein"
                     /protein_id="WP_069861014.1"
                     /transl_table=11
                     /translation="MGAQAAPTLITSVQRAFRLMEAVGAHECGAPAKRLARETGLPLAT
                     TYHLLRTLAYEGYVHRLEDGGFVIGDKLRTLESGSRGQAMLSRIRPTLASLRDELSAAA
                     YLTFYDEGEIRVVEIVDGPQAPRVDLWVGFEDAGHATALGKCVLRELDDDARHEYLSRH
                     ELVDLTPRTVTRPGDLLRRLDSPTNSPLVADLEEYALGTVCFAVPIYYGDRLGSLGISL
                     PADRFARLAKLDPHRELFRTHLVPTASRVSRNLSLTI"
     misc_feature    complement(6267..6281)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     gene            complement(6370..6828)
                     /locus_tag="BV401_RS22080"
                     /old_locus_tag="BV401_22130"
     CDS             complement(6370..6828)
                     /NRPS_PKS="Domain: Polyketide_cyc (9-126). E-value:
                     5.2e-15. Score: 47.8. Matches aSDomain:
                     nrpspksdomains_BV401_RS22080_Polyketide_cyc.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009716668.1"
                     /locus_tag="BV401_RS22080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_22130"
                     /product="SRPBCC family protein"
                     /protein_id="WP_069861015.1"
                     /transl_table=11
                     /translation="MSTVRESVEVGVPLRTAYDQWTQFTEFPRFMEGVDQVIQVDDRHN
                     HWATSIAGVHREFDTEIVDQLPDERIAWRTTSGDVRQQGLVTFEPVDERHTRVNLAMVF
                     EPSGMAEKAADMTGTLDRRVKGDLRRFKDFIERRGEAEGAWRGRISPG"
     aSDomain        complement(6451..6801)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BV401_RS22080_Polyketide_cyc.1"
                     /domain_subtypes="Polyketide_cyc"
                     /evalue="5.20E-15"
                     /label="BV401_RS22080_Polyketide_cyc.1"
                     /locus_tag="BV401_RS22080"
                     /protein_end="126"
                     /protein_start="9"
                     /score="47.8"
                     /tool="antismash"
                     /translation="VGVPLRTAYDQWTQFTEFPRFMEGVDQVIQVDDRHNHWATSIAGV
                     HREFDTEIVDQLPDERIAWRTTSGDVRQQGLVTFEPVDERHTRVNLAMVFEPSGMAEKA
                     ADMTGTLDRRVKG"
     gene            complement(6951..8216)
                     /locus_tag="BV401_RS22085"
                     /old_locus_tag="BV401_22135"
     CDS             complement(6951..8216)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061815.1"
                     /locus_tag="BV401_RS22085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_22135"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_167746841.1"
                     /sec_met_domain="DAO (E-value: 9.4e-64, bitscore: 215.1,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTAIGPSRPPRGAVVVGAGMVGLATAWSLLNHGVEVTVVERRHP
                     AAGASWGNAGWLSPALTLPLPEPAALRYGLRGLLSPESPVYIPPRPDPRLARFLLTFTR
                     NCTPRRWRVLAATFATLGRQALDAYDTLAADGVAEPTRPAEPCLIAFRTAAERAVMIEE
                     LEQARAAGFTIAYEPVDGDRARALEPALGDAIGAAVELHGQRYLNPGNFVRALADAVRE
                     RGGEILERTEVSGIRDLGRGVAVTTSGGQLHADVAVVATGAWLDALVRPFGVRVPVQAG
                     RGYSFSVPAEGAPTRPTYLAAQKVVCTPLDEGRVRVAGMMELAPAERPVDPRRIRAIIA
                     AARPLLRGIDWAARTDTWVGARPCTPDGLPLIGPTGSPRVYVNGGHGMWGVALGPLSGR
                     LLAEAIATGTSPAELAPLHPLR"
     gene            complement(8410..9834)
                     /locus_tag="BV401_RS22090"
                     /old_locus_tag="BV401_22140"
     CDS             complement(8410..9834)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1105: amidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061816.1"
                     /locus_tag="BV401_RS22090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_22140"
                     /product="amidase"
                     /protein_id="WP_079258181.1"
                     /transl_table=11
                     /translation="MTTTDDDLCFRTALDLGHLLRTRELSARELLEAHLARIERVNPAV
                     NAIVTLVADRAREAARQADERIVAGEELGPLHGLPIAHKDLHDTAGIRTSHGSPLVDGV
                     PDQDDLLIERIRAAGAITIGKTNVPEFGAGSHTFNPIFGATHNPYDLGRSAGGSSGGAA
                     AALASGMVPIADGSDTGGSLRNPASFCNVVGLRPSPGRVPNWPSMTAWSTLGVKGPMAR
                     TVADTALLLSAIAGPDARSPIALEEPGARFARPLDRDLTGLRVAWSPDLGGLVPVEPEV
                     AEAVAAAAEVFTGLGCVVERACPDLAEAEEVFRTLRASAFEVAFGALMDAHPDGLKRAI
                     RENAEQGRKLTGPDVARAEVLHTQLFHRVREFFGRYDVLLLPVSQVVPFDVGIEYPTEI
                     AGVAMDDYLDWMRSAYLISSTGSPALSVPAGFTPGGLPVGVQIVGPHRADFAVLQVGHA
                     FEQATGHWRRHPAGLG"
     gene            complement(10001..12397)
                     /locus_tag="BV401_RS22095"
                     /old_locus_tag="BV401_22145"
     CDS             complement(10001..12397)
                     /EC_number="4.2.3.-"
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016578885.1"
                     /locus_tag="BV401_RS22095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_22145"
                     /product="terpene synthase family protein"
                     /protein_id="WP_193524983.1"
                     /sec_met_domain="T1TS (E-value: 1.1e-82, bitscore: 277.6,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPFRLPDFYMPYPARLNPHVQEAREHSTQWAREMEMLEGSGIW
                     EQEDLDAHDYALLCAYTHPDCSGTELSLVTDWYVWVFFFDDHFLETFKRSQDRAAGKAY
                     LDRLPAFMPMDPADGTPEPTNPVEAGLADLWARTVPSMSSDWRARFRESTENLLNESLW
                     ELSNINIDRVPNPVEYIEMRRKVGGAPWSAGLVEHAVRAEVPAVIAGSRPMRVLRDAFA
                     DAVHLRNDLFSYQREIEEEGELSNGVLVLETFLDCTTQEAADSVNELLTSRLQQFEDTA
                     LTELGPLFAEHELDPAACAGVLAYVKGLQDWQSGGHEWHMRSSRYMNGAHKASEAHGAD
                     GPRGAHGVHEAGDAHGTNGAGGTGRRSERAPWSPFALTGLGVSAASLPLTTGRAEAARA
                     RRFSHVPFQRTGPSLLPDFSMPFTLRLNAHLPTARRHLVDWAHRMGILEPQPGVPGSQV
                     WDERRLLAADLPLCAAGIHPDGSPEELDVASGWLAWGTYADDYYPAVFGRTHDLAGARA
                     CNARLGAFMPLDAGPTPVPANALERSLADLWGRTAGPMEVAARRDLRQAIEDMTASWLW
                     ELANQTKHRIPDPVDYIEMRRHTFGSDLTMSLCRLAHGRRVPPEIYRSGPVQSLESAAA
                     NYATLLNDVFSYQKEIEFEGEVHNGVLVVQNFFDCDYPTGVAIVNDLMTSRMRQFQHVA
                     EHELPVLYDDFGLGPEARKAMDGYVEELSHWMTGILNWHREVPRYREEELLRVHRRPVG
                     AGWRPVAAGAGAGARAVAPWHGPTGLGTSAARVPVPVGAGLSARP"
     misc_feature    12504..12518
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.93"
                     /tool="antismash"
     gene            complement(12578..13750)
                     /locus_tag="BV401_RS22100"
                     /old_locus_tag="BV401_22150"
     CDS             complement(12578..13750)
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061819.1"
                     /locus_tag="BV401_RS22100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_22150"
                     /product="acyltransferase family protein"
                     /protein_id="WP_069861019.1"
                     /transl_table=11
                     /translation="MNVSSLLPARRAPASPPPEAAPASSPAPKQRDAFFDNAKYLAIVL
                     VAMGHAWEPLRGGSRAASALYMTVYTFHMPAFILISGYFSRNFDLRPDRLKRLITGIAV
                     PYVLFEVAYTFFKRWADDDPSYPISLLDPWYLTWFLIALFVWRLTTPLWRIVRWPVALA
                     LGVAALAACSPNIGDDLDLQRVLQFLPFFVVGLHMRPEHFRMIRRRAVRRLSVPVVAAA
                     LVFAYWAVPRMNPEWFYRRDSAQELGAPWWVGTVMTFALFGCSMVLTVCFLAWVPRRRM
                     WFTVLGAGTLYGYLLHGFLAKGSRFWDWYDHPWLHRPLGEIVVTAVAVAVVTALCTPPV
                     QRMFRFAMEPRMEWAFRPTGRSGGGPSEQGGSAPAVPVGAQAAGRSHGPE"
     misc_feature    complement(13733..13735)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    13736..13750
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.15"
                     /tool="antismash"
     misc_feature    13933..13949
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.47"
                     /tool="antismash"
     misc_feature    complement(14020..14035)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.15"
                     /tool="antismash"
     gene            14065..14520
                     /locus_tag="BV401_RS22105"
                     /old_locus_tag="BV401_22155"
     CDS             14065..14520
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675687.1"
                     /locus_tag="BV401_RS22105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_22155"
                     /product="TerB family tellurite resistance protein"
                     /protein_id="WP_069861020.1"
                     /transl_table=11
                     /translation="MALWDRIKESAQTMQTQLVSKKNDLKSGAFRDASMAMCALVAAAD
                     GSVDPSERQRVAQLIATNEVLQNFPADDLQRRFNDYVNKLTADFEFGKVSVMQEVAKAK
                     KKPAEARAVVQIGIVIGGADGNFDKSEQAMVREACYTLDLPPAEFDL"
     gene            complement(14657..15604)
                     /locus_tag="BV401_RS22110"
                     /old_locus_tag="BV401_22160"
     CDS             complement(14657..15604)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009313596.1"
                     /locus_tag="BV401_RS22110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_22160"
                     /product="M56 family metallopeptidase"
                     /protein_id="WP_079258183.1"
                     /transl_table=11
                     /translation="MGVFVFLPLVLPLTALPIARLAEQHLHPRTATRLLTLVGTVLAVC
                     STLCLGLLMVVGTAQLPGNPLPDSWSDPEVRAAVPYDVVAGKAAIGALAAVAVSCTATC
                     LRHSRVRRNAWLALAGLPESPVAVLPDDRPYAYALPGTSGRTGKPGRIVVSTGMLDSLS
                     TRERRALIAHERAHLTAHHHRYLLGAQLAARANPLLRPLRAAVDYCAERWADEEAAREV
                     GDRRVTARAVGKAALVSRGTPGPALAGFAAPGPVPRRVAALLGPVPPPRHWPPTWTAAG
                     LALWIAAVGTAASALSSANAAVALVLVLHAATPL"
     gene            complement(15608..16021)
                     /locus_tag="BV401_RS22115"
                     /old_locus_tag="BV401_22165"
     CDS             complement(15608..16021)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061822.1"
                     /locus_tag="BV401_RS22115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_22165"
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="WP_069861022.1"
                     /transl_table=11
                     /translation="MTDHDRTGGPGWPRRPRRRGQGELEAQVLVALRRAPGPVTAAWVQ
                     ERIEGELAYTTVMTILSRLHAKQAVTRERAGRSFVWRAASDEAGLAALRMRRVLDGQDD
                     REAVLASFVTGLTQDDERLLRDLLSDVAEEPEG"
     gene            16209..17489
                     /locus_tag="BV401_RS22120"
                     /old_locus_tag="BV401_22170"
     CDS             16209..17489
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061823.1"
                     /locus_tag="BV401_RS22120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_22170"
                     /product="cytochrome P450"
                     /protein_id="WP_079258184.1"
                     /sec_met_domain="p450 (E-value: 6.9e-27, bitscore: 93.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQTQGSLVRQITDYAHRADPYPLYAELRKTPVAHDEEGPYIVST
                     YWEIHGLLHDPRLSSDARNLDPRAAPELIEEDGEEDEPGLPPSFLRLDPPEHDRLRSLA
                     MAPFGPPNTPRRLHTMRGELTRIVGELIDGFEGRDRIDLVDHFSYPFPVTVICRLLGVP
                     REDEPRFHAWADTVAAGLDPDPDADEDAAERRRVSRQARTDLAVYLSELIEERRRAPGD
                     DMLSALVGWEGPEGRMSRVELLSTAALLLVAGHETTVNLITNGMLTLLRNPEVLARLRN
                     DPHLVVPLVEELLRFDPPVQMLPRRTPLSEIDIAGVTIPRGASVWLLLASGNRDPQRFL
                     DPDRFEPQRRDNQHLGFGSGVHSCFGAPLARLEAQIALTELARRLDGPRLLEDPPTYRR
                     NAVLRGPRHLPLAFEGLRPGGSPNGSR"
     gene            complement(17532..19148)
                     /locus_tag="BV401_RS22125"
                     /old_locus_tag="BV401_22175"
     CDS             complement(17532..19148)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061824.1"
                     /locus_tag="BV401_RS22125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_22175"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_237287751.1"
                     /transl_table=11
                     /translation="MGLPERPPEPHRASEPHRTPQPHHAPQPRRCLVTGATGYIGGRLV
                     PELLAAGHQVRCVARSPEKLRDHPWAARVETVRGDVTDEESLRAAMEGVDVAYYLVHAL
                     GTGPGFEETDRRAARIFGARARAAGVRRIVYLGGLTPYGVPERALSPHLRSRAEVGRVL
                     LGSGVPTAVLRAGVIIGSGSASFEMLRYLTERLPLMVTPRWVRTRTQPIAVRDVLRLLV
                     GCATLPDEVHRAFDIGGPDVLTYGAMMQRYAEVTGLRRRLIAQVPVLTPGLSSLWVGLV
                     TPVPGAIARPLVESLRHEVVCAERDITRYVPDPPGGPLGVDRALELALRRIRDADVATR
                     WSSAATPGAPSDPLPTDPDWAGGSLYQDRRERAVDASREDVWRVVEGIGGENGWYSLPL
                     AWALRGWIDTLVGGVGLRRGRRDAARLRVGDSLDFWRVEEVRPPRLLRLRAEMRLPGLA
                     WLEMVVDGDGRGRTVYRQRALFHPRGLAGHLYWWSVAPFHALVFGGMARNIAARAEKDE
                     AGTETGGKGADGRSAPAVRMR"
     gene            19499..19798
                     /locus_tag="BV401_RS22130"
                     /old_locus_tag="BV401_22180"
     CDS             19499..19798
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003949502.1"
                     /locus_tag="BV401_RS22130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_22180"
                     /product="type II toxin-antitoxin system VapB family
                     antitoxin"
                     /protein_id="WP_014061825.1"
                     /transl_table=11
                     /translation="MIFKRIGNGRPYPDHGRESTRQWADVAPRPVRLDQLVTTKQQLDL
                     ETLLAEDSTFYGDLFAHVVKWQGDLYLEDGLHRAVRAALQQRQVLHARVLELEG"
     misc_feature    19890..19906
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.24"
                     /tool="antismash"
     gene            19936..20640
                     /locus_tag="BV401_RS22135"
                     /old_locus_tag="BV401_22185"
     CDS             19936..20640
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005315293.1"
                     /locus_tag="BV401_RS22135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_22185"
                     /product="LytR C-terminal domain-containing protein"
                     /protein_id="WP_069861024.1"
                     /transl_table=11
                     /translation="MSMLTPPGMGGKYRITGDRYPRMSRPRSRRRLVFASFGSVMALGL
                     VGWGTLQLIDVFSGDSGDQKVRAANGTGECERGDKGPAENNAKSGRGDSGQGGQGGHGG
                     RTGGKLPKPSQITVNVYNATTRSGLAKDTAEELEKRGFKIGKVGNAPARYDKKVKSPGM
                     LLGAPGAGDGAFNVLGTQLNGAQTKNDARDGKDIDLIIGNGFKDLVKQKDADKALTALA
                     KPSPTPSGTPCH"
     gene            complement(20781..21416)
                     /gene="upp"
                     /locus_tag="BV401_RS22140"
                     /old_locus_tag="BV401_22190"
     CDS             complement(20781..21416)
                     /EC_number="2.4.2.9"
                     /GO_function="GO:0004845 - uracil phosphoribosyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="upp"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004943140.1"
                     /locus_tag="BV401_RS22140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_22190"
                     /product="uracil phosphoribosyltransferase"
                     /protein_id="WP_020870138.1"
                     /transl_table=11
                     /translation="MRIHVVDHPLVAHKLTTLRDKRTDSPTFRRLADELVTLLAYEATR
                     DVRTEQVDIETPVTATTGVRLSHPRPMVVPILRAGLGMLDGMVRLLPTAEVGFLGMIRD
                     EETLQASTYATRMPEDLSGRQVYVLDPMLATGGTLVAAIRELISRGADDVTALCLLAAP
                     QGVELMERELAGAPVTVVTSSVDERLNEQGYIVPGLGDAGDRMYGAAG"
     gene            21599..21766
                     /locus_tag="BV401_RS43570"
     CDS             21599..21766
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061828.1"
                     /locus_tag="BV401_RS43570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_167459926.1"
                     /transl_table=11
                     /translation="MADATAMETSADRRRRRERFLRALNEARAVRNQVRPRQARAARMR
                     RAIHLRTFSW"
     misc_feature    22261..22276
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.5"
                     /tool="antismash"
ORIGIN
        1 cgtccgcgtg caccgcgagg tcggcgcgca gcacctggcg ggcctgggcg tcgcccgcgt
       61 gggtcagcgt cgcgcccccg gagagctgaa ccccggcgaa cgcggtgacc agcacgatcg
      121 gcgtgatcgc cgcgcccagc cggtgtgcgg acgccgcgca gttggcggcg gcgaggcggc
      181 cgccggggcc gaacagccgc agcggagcgc ccagcagccg catcgccccc tcggcgatcc
      241 acggtccgag caccgcacag gcgatcacca tggtcaccgc cgccgcaccg gccgcggccg
      301 ccgcggtcgc gccccgctgg agggcggccg tcccggcggc gctcgcgccc acgcccagca
      361 gcaccagccc ggtgataccg cgccccctgc cgggcgcccg ctcgcgcagc gcctccgccg
      421 gacgcgccgt ggcggtcctg gcgccgccaa tgagcgccgc gacctgggcc accaggaccg
      481 tgacggcggc ggtgaccagc ggcgtgagcc acagtggcgg gagaagcgtc agctcgagtc
      541 cggtgggcag cgcgccccgc gcgtccagca gcgcgcgcag ccccaggtac gcgggggccg
      601 ccccggccgc gcccaccagc gccgcccaga ccgcgacccg ccccacctcc cggcccaccg
      661 ctgcgcgcag ctgccccggt gtggcaccga ccgcccgcaa caggcccagt tcatgggagc
      721 gttgacgcag cgcctggacg atggtcgacg acaccaccag cagcgacacc aggacgacgg
      781 ctccggccac ggagcccaga gccgccagca gctcaccacg ggccggcgcg gcggccagga
      841 actccgcctc gccccggtcg tccccggtca ggacgcgcac ggtggccggg tcgccgtccg
      901 cgcgatgccc gacgtcggtg actccggccg tgtccagcgc cttccgcacc cgcccggcca
      961 gctcccccgc gcccgtgccg gattcggcga cgaccccgat ggcgtccagc gcctccgggt
     1021 ggccggacag acggcgggcc tcggcgccgg tgaaccagac ggcggtacgg gggccgtcgg
     1081 cgacgcccac gacggtgtac gccatgtcgt gaccgcccac gcgcagcgtc agccgctggc
     1141 cgacgcggtc cgccccgccg cgttcggggc cgccaccgcc cgccacgacc acctcgtccg
     1201 cgcgctgcgg ggcgcgtccc gtccgtagcg cgtagggggc cagccgggcg gcctcccagg
     1261 gccgcccggt ggcggactcg gtggcggacc cggtggccgc cgaccccgcg aggcccaccg
     1321 ggaattccac gtcggcgacg gccgcccgca cccctggcac cccgcgcacc acggtcaacg
     1381 ccgtgcgggg gatccggacc cgttcggtga gccccgcgct cacggtctcg cgttcgccca
     1441 gcgacgccgc gctgaagcgg gtggtctggt cgccggccac gacgagatcg gccccggcgt
     1501 accgctccac ccgcggatgc gcgctccagg ccgagacgag ggtcagcccg aaggcgccga
     1561 gcagcaggga ggtgagggtg agcgcggcga agaccgcggt ccacgcctta cggtgggcac
     1621 gagtggcgcg agtggccagc agggcggcga ccttcatgcc gtccgccctc ccaggtcctt
     1681 caggacgcgg cgtatgtcgg ccgcctccgg gcgctcctgc cgccacacca gcttcccccg
     1741 catcagaaaa agtgcctcgt cggcccaggc ggcggcgaac gggtcatggg tgaccatgac
     1801 gaccgtatgg ccgtcacggt cgacggcctg ccgcagcagc gtcagcgcct cctccgcagc
     1861 ggcggggtcg agcgcccccg tcggttcgtc ggcgaagacg atgtcgggcg aggtcaccag
     1921 cgcacgggcg atcgccaccc gctggcactg cccgccggac agctccgacg gcagggcgcc
     1981 gccccggtcc cccagcccga ccgccgcgag tgcccgccgc tcccggccgt cgacgggccg
     2041 gccgccgagc atcagcggca gggagacgtt ctccgccacg gtgagcgacg gcaccagatg
     2101 gtgcgcctgg aagacgaagc cgatccgctc ccgccgcagc cgggtcagcg ccgcctcgtt
     2161 cagcgaggac agctccgtgc cgccgatgcg caccgtgccc gccgtcggcc ggtcgagccc
     2221 ggcggcgcac tggagcaagg ttgacttccc gcaccccgag ggccccatca ccgcgaggaa
     2281 ccgtccgcgc ggcaccgtca gatggatggg gtgcagcgcc acggccccca gccggtactc
     2341 cctggtgacc ccgtccaggg ccagcgcatg gtgccaggtc cccgtccgct ccacggtggc
     2401 cgtcctgcgg ccgcgccact gccggttcat ctctccgccc ctccgtcacg tccgggcgga
     2461 tcaaacgggt ccgcctgtca ccgagaacgc tagaaacggg cgcggccgcg cggcagagag
     2521 cgcggtcccg tactggaagt ggtacggacc cccgcccggg ggtggagccc actccaccat
     2581 cgccgctgcg tcccgtctcc cacacggttc cgccaggtcc ggcatccggt cctccgtccg
     2641 ctctcgcgtc cgaacttccc cgtccgcggg cgacatccgg gcgcgccgcc gtggtgaacc
     2701 ccgccgggga caagatcctg gacaccccca caggaccggc atatgagaca gaagaccaca
     2761 gagaggcacc agacacccat ggacgtcagc gcccgtatcg aggccgtcta cgcgcagatc
     2821 gtgcaccgca accccgggga gtcggagttc caccaggcgg cgcgcgaggt gctgccggcc
     2881 ctcgcccccg tgctcggcgc gcatccggag tatgtggacg cccggatcgt ggagcggctg
     2941 tgcgagccgg agcggcaact cgccttccgg gtgccctggg tggacgacga cggcgaggtc
     3001 caggtcaacc gcggcttccg ggtggagttc agcagcgcgc tgggccccta caaggggggc
     3061 ctgcgcttcc accccagcgt caatctgggc atcgtgaagt tcctcggctt cgagcagatc
     3121 ttcaagaacg cgctgaccgg tctggccatc ggcggcggca agggcggtgc ggacttcgac
     3181 cccaaggggc gctcggacgg cgaggtgatg cggttctgcc agtcgttcat gaccgaactc
     3241 caccgccatc tgggcgagca caccgatgtg ccggccgggg acatcggggt gggcgcccgt
     3301 gagatcggct atctcttcgg ccagtacaag cggctgacca atcgcttcga ggccggtgtg
     3361 ctgaccggca agccggtcgg ctggggcggt tcacacgcgc gtaccgaggc cacgggttac
     3421 ggcaccgtcc acttcgccca ggagatgctg cgcacccgta agaaggattt cgacggcctt
     3481 acggtcgtcg tctccggatc cggcaatgtg gcgctctacg cgatcgacaa ggtccacgcc
     3541 ctcggcggcc gggtggtggc ctgctccgac tcctccggcc atgtggtcga cccggacggt
     3601 atcgacctcg ccctgctgaa ggagatcaag gaggtccgcc gggggcggat cgacgcctac
     3661 gccaccgcca agccgggcgc cgtcttctcc ggccgcggct cggtcttcga ggtgccctgc
     3721 gaggtcgtcc tgccctgcgc gacccagaac gagctgaccg agcagtgcgc gatcaccctg
     3781 gtcaagaacg gcgtactggc cgtggccgag ggcgccaaca tgccctgcac cccggcggcg
     3841 atcgagatct tccgggaggc cgatgtgctc ttcggccccg gcaaggccgc caacgcgggc
     3901 ggggtggcca cctccgccct ggagatgcag cagaacgcct cccgcgaacg ctggaccttc
     3961 gcccagaccg aggcccgcct cgccgccgtc atgaccgagg tccacaccct gtgccgcacc
     4021 accgccgacc gctacggctg ctcccccgac gactacgccc tgggcgcgaa cgccgccggg
     4081 ttcgtgcggg tcgcggaggc gatggccgcc cagggcatcg tctgagccgg tcggtcgcgg
     4141 ccggggccga tcaccgacag aggccggagg ccatacggac aaccaacact gacggcacag
     4201 atcacatcga cggcatttcg gccgccccgc gcatcgcgcc cagcaccggc ttgcggagca
     4261 gcagcagcgc cgcgtcgtcg tggagccgac cgcccacatg ggacagcagt tcggcgtgga
     4321 gcgaggcgag ggtgcgggac ggctcgtcgc agatatgccg cggcacccgt tccagcagcg
     4381 ggaagtactc ccggccgcgg tcccgcgcct cgatgacccc gtcggtgtag agcagcagtt
     4441 ggtcaccctc gatgaacggc accacctgga ggctcggcag ctcgccgccc agggaggcca
     4501 ggccgagcgg cggggccgga cggatgggct cgacggcgct gacccctgac tcgccgaaca
     4561 gcagcggcgg ggcatgtccg cagttgacga gctccatccg gccctcgctg gggtagccgg
     4621 cgaccacggc ggtgacgaag tcgtcgggcg ccaggttacg ggccaggctg cgctcgatcc
     4681 tgccgacgac gtcgagcaga tcgcgttcgt cgtaggcggc ctcccggaag acgccgagca
     4741 ccagcgcggc ggtgctcacc gcgggcagcc ccttgccgcg cacatcgccg acgatcagcc
     4801 ggactccgtg cggggtggac agcagggcgt agagatcgcc gcccacccgc gcctccgcgg
     4861 cggcggcgct gtagcgaacg gccacctgga actcgccgac ctgggcgggc accggcgtga
     4921 gcagggcgtt ctgggcggcc tcggcgaccg agcgaacggc ggcgagcacc tgctcacggc
     4981 gctggcgcat ggcgctggcc ccacagctcg ccagggccac ggcggcgggc gtggccagca
     5041 tgatcgcctg ggtgcgcagc gtctcctcgc cctgggtgcc cagcagggca cccaccccca
     5101 cggcgagcag cccgatgcgc atcaccccgt acggccccca gtgggcggcg gcgagcgccg
     5161 ggccgacggc gagcatcggc agccagccga gcccctccga ggtgacgagg gccagcaggg
     5221 ccacaccaat gatgatgaat acggggaccg cgggggcgat gagccctgtg ccgtccatct
     5281 ggtccgggtc gtacgtgcgg agtcgggccg ggtacatgac ctgcttcgct gctctcttcc
     5341 acgagtgata ccgggggtgt ccgtttcatc cagagaagca gcgattagat aggtttcgca
     5401 agggacgcgt tttcagatag tgagcgagag gttcctgctc acccggctcg ccgtcgggac
     5461 cagatgggtc cggaacagct ctcggtgcgg atccagcttc gccagccgcg cgaaccggtc
     5521 cgcgggcagc gagatcccga gcgagccgag ccggtcgccg tagtagatcg gcaccgcgaa
     5581 gcagaccgtg cccagggcgt actcctccag gtccgcgacc agcggactgt tggtcgggga
     5641 gtccagccgg cgcagcagat cgccggggcg ggtgacggtc cgcggtgtga gatcgacgag
     5701 ctcatggcgg gacaagtact cgtggcgggc gtcgtcgtcc agctcgcgca gtacgcattt
     5761 gcccagcgcg gtggcgtgcc cggcgtcctc gaaccccacc cacagatcga cccggggcgc
     5821 ctgcgggccg tccacgatct ccaccacccg gatctcgccc tcgtcgtaga aggtgaggta
     5881 ggcggcggcg gagagctcat cgcgcagcga ggccagggtg gggcggatcc gggagagcat
     5941 cgcctggccc cggctgccgg actcgagggt gcgcagcttg tcgccgatca cgaagccgcc
     6001 gtcctccagc cggtgcacat agccttcgta cgccagcgtc cgcagcaggt ggtacgtggt
     6061 ggcgagcggc agccccgtct cccgggcgag ccttttggcc ggcgcaccac actcgtgcgc
     6121 acccaccgcc tccatcagcc ggaaggcccg ctgtacggat gtgatcagcg taggcgccgc
     6181 ctgagcaccc atatgtccag cttgctcctg gtagagggga tgagcaagat ctgcgcgtcg
     6241 gacgcgggcg agggcgccgg ccgatgtggc cgacgccctc gcggacgtgc actcgcgggc
     6301 aggtggaccg gtgcgaccgt gccaccggtg cggtcggtgc aatcggtgcg accgatgcga
     6361 ccggtgcggt cagccgggtg agatccggcc gcgccaggcg ccttccgcct cgccgcgccg
     6421 ctcgatgaag tccttgaacc tccgcagatc ccccttcacc cgccggtcga gcgtcccggt
     6481 catgtccgcg gccttctccg ccatcccgct cggctcgaag accatggcca gattgacccg
     6541 ggtgtggcgc tcgtcgacgg gctcgaaggt caccagaccc tgctgccgca catcaccgga
     6601 ggtggtgcgc caggcgatgc gctcgtcggg aagctgatcc acgatctcgg tgtcgaactc
     6661 ccggtgcaca ccggcgatgg aggtcgccca gtggttgtgg cgatcgtcca cctggatgac
     6721 ctggtccacg ccctccatga acctcgggaa ctcggtgaac tgcgtccact ggtcataggc
     6781 ggtgcggagc ggaaccccaa cctcgacgga ctcccgcacg gtgctcatcg gtggctcctt
     6841 tcgacgttgt cgcgacgctc agcacggcgg gtttccgaga ccgccgggcc aaaacatgcc
     6901 gcgcccaggc ggtctgtgcg accgagcggg gatggacggc aggcggcggc tcagcgcagc
     6961 ggatgcagcg gggccagttc ggccggggag gtgccggtcg cgatggcctc ggccagcagc
     7021 cgtccgctga gcgggccgag ggccacgccc cacatgccgt ggccgccgtt gacgtagacc
     7081 cgcggggagc cggtcgggcc gatcagcggc agtccgtcgg gggtgcacgg gcgggcgccg
     7141 acccaggtgt ccgtacgggc cgcccagtcg atgccgcgca gcagcggacg ggccgccgcg
     7201 atgatcgccc ggatccggcg cgggtccacc ggccgttccg cgggcgccag ttccatcatc
     7261 ccggcgaccc gcacccggcc ctcgtccagc ggggtgcaga cgaccttctg ggcggccaga
     7321 tacgtgggcc gggtgggggc gccctcggcc ggcacgctga agctgtaacc gcgtccggcc
     7381 tggaccggca cccggacccc gaacgggcgg accagcgcgt ccagccaggc gccggtggcc
     7441 acgacggcga cgtccgcgtg gagttggcca ccggaggtgg tgacggccac gccccgcccg
     7501 aggtcccgga ttccggacac ctccgtccgc tccaggatct cgccaccgcg ctcgcgcacc
     7561 gcgtcggcga gggcgcgcac gaagttcccc gggttcagat agcgctgacc gtggagttcg
     7621 acggccgcgc cgatggcgtc gccgagcgcg ggctccagcg cacgggcccg gtccccgtcg
     7681 accggctcgt acgcgatcgt gaaaccggcc gcgcgggcct gctccagctc ctcgatcatc
     7741 acggcccgct cggcggcggt gcggaaggcg atcaggcagg gttcggcggg ccgggtgggc
     7801 tcggcgacgc cgtccgccgc gagcgtgtcg tacgcgtcca gcgcctggcg gcccagcgtg
     7861 gcgaaggtgg cggccaggac ccgccagcgg cgcggggtgc agttccgggt gaaggtgagc
     7921 aggaagcggg cgagccgggg gtcgggccgg ggcgggatgt agacgggcga ctcgggggag
     7981 agcaggccac gcagcccgta gcggagcgcg gccggttcgg gcagcggcag cgtcagggcc
     8041 ggggacaacc agccggcgtt cccccaggac gccccggccg cggggtggcg ccgctccacg
     8101 acggtgacct cgacgccgtg gttcagcagc gaccaggcgg tggcgaggcc gaccatgccg
     8161 gcgccgacga cgacggcgcc gcgcggtggg cgggacggac ctatggcagt gggcacggat
     8221 gcgctccttc ccatgggtga aacgccatca tcggtggaac gggccgggca ccgcaccggc
     8281 ccgcggccct gatcgccctc tggctgccgg gtgccgtgct cgccccctcc cggggcgccg
     8341 atcaccccgg gccgcccgcg gccctgatcg ccctcggccc cgtcgcccgc ggccctgatg
     8401 gcccccccgc tacccgaggc ccgccgggtg ccgtcgccag tgcccggtgg cctgctcgaa
     8461 ggcgtggccg acctggagga ccgcgaagtc cgcccggtgc ggcccgacga tctgcacccc
     8521 gaccggaagc ccgccgggcg tgaacccggc cggtacggac agcgccgggc tgccggtcga
     8581 gctgatcaga tacgccgagc gcatccagtc cagatagtcg tccatggcca ccccggcgat
     8641 ctcggtcggg tactcgatcc cgacgtcgaa gggcaccacc tggctcaccg ggagcagcag
     8701 cacgtcatag cggccgaaga actcccggac acggtggaag agctgggtgt gcagcacctc
     8761 cgcgcgggcg acgtccggcc cggtgagctt gcgcccctgc tcggcgttct cccgtatggc
     8821 ccgcttcagc ccgtcggggt gcgcgtccat gagcgcgccg aaggcgacct cgaacgccga
     8881 ggcgcgcagc gtacggaaga cctcctcggc ctcggccagg tccggacagg cccgctccac
     8941 gacgcagccg aggccggtga agacctccgc cgccgccgcg accgcctcgg ccacctcggg
     9001 ctcgaccggc accagccccc cgagatccgg cgaccaggcc acccgcaacc ccgtcagatc
     9061 gcggtccagg gggcgggcga aacgggcgcc gggctcctcc agggcgatcg gtgaccgagc
     9121 gtcgggtccg gcgatggcgg acagcagcag ggcggtgtcg gccacggtac gggccatcgg
     9181 ccccttgacg ccgagggtgc tccaggcggt catggagggc cagttgggga cgcgcccggg
     9241 cgacgggcgc agaccgacca cattgcagaa cgaggccggg ttgcgcagcg agccgccggt
     9301 gtcgctgccg tccgcgatcg ggaccatgcc ggaggccagc gcggccgccg cgccaccgct
     9361 gctgccaccc gcgctgcggc ccaggtcgta cgggttgtgg gtggcgccga aaatggggtt
     9421 gaaggtgtgc gaaccggccc cgaactcggg cacgttggtc ttgccgatgg tgatcgcccc
     9481 ggcggcccgg atccgttcga tcagcagatc gtcctggtcg ggcacgccgt cgacgagcgg
     9541 cgagccatgg ctggtgcgga tgcccgcggt gtcgtggagg tccttgtggg cgatgggcag
     9601 cccgtgcagc ggcccgagct cctcccccgc cacgatccgc tcatcggcct gccgggccgc
     9661 ctcacgggcg cggtcggcga cgagggtgac gatcgcgttg acggcggggt tgacccgttc
     9721 gatacgggcc agatgggcct cgagcagctc gcgcgcggac agctcgcggg tgcgcagcag
     9781 atggccgagg tccagggcgg tcctgaagca gagatcgtca tcggtcgtcg tcacggtcgc
     9841 tcgccttcct cacggggccc aggggcgcaa cccatcgttc gggaagcggc cgggtgaggg
     9901 aagagcgtcg ggccggagag ccggcaccgg ccgcctcgcc ctgtcccggc ggacagggcg
     9961 aggacgccgg ccgaagtcct tacggacgtg ctcgcggtcc ttacggacgc gctgacagac
    10021 ctgctcccac gggcaccgga acccgcgcgg ccgaggtgcc gagcccggtg ggcccgtgcc
    10081 acggggccac cgcccgcgcg cccgcaccgg ccccggccgc caccggccgc cacccggccc
    10141 ccaccggccg ccggtggacg cggagcagct cctcctcccg gtagcgcggg acctcccggt
    10201 gccagttcaa gatcccggtc atccagtggc tcagctcctc cacatagccg tccatcgcct
    10261 tcctggcctc cggccccagg ccgaagtcgt cgtacagcac ggggagctca tgctcggcga
    10321 catgctggaa ctgccgcatc cgggaggtca tcaagtcgtt cacgatggcg accccggtcg
    10381 gatagtcgca gtcgaagaag ttctggacga cgaggacgcc gttgtggacc tcgccctcga
    10441 actcgatctc cttctggtag gagaagacat cgttcagcag cgtcgcgtag ttcgcggcgg
    10501 cgctctccag cgactggacc gggccgctgc ggtagatctc gggcggcacc cgccgtccgt
    10561 gcgccagtcg gcacaggctc atggtgaggt cggagccgaa ggtgtgcctg cgcatctcga
    10621 tgtagtcgac cggatcgggg atccggtgct tcgtctggtt ggccagctcc cacagccagc
    10681 tggcggtcat gtcctcgatg gcctggcgga ggtcgcggcg cgccgcgacc tccatcgggc
    10741 ccgccgtacg gccccacaga tcggccagcg agcgctccag cgcgttcgcc gggacggggg
    10801 tggggcccgc gtcgagcggc atgaaggccc cgagcctggc gttgcacgcc ctcgctccgg
    10861 ccaggtcgtg ggtgcggccg aagaccgccg gatagtagtc gtccgcgtag gtgccccagg
    10921 ccagccagcc cgacgccaca tcgagctcct ccggggagcc gtccggatgg atgcccgccg
    10981 cgcacagcgg gaggtcggcg gcgagcagcc gccgctcgtc ccagacctgc gaaccgggga
    11041 cgccgggctg cggttcgagg atgcccatcc ggtgtgccca gtcgaccaga tggcggcggg
    11101 cggtgggcag atgcgcgttg agccggaggg tgaacggcat ggagaagtcc ggcagcagcg
    11161 acggcccggt cctctggaac gggacatggc tgaacctgcg cgccctggcc gcctccgccc
    11221 ggccggtggt cagcggcagg ctggccgcgg agactccgag gccggtgagc gcgaaggggg
    11281 accatggagc gcgctcgctc cgccgaccgg tgccacccgc accgttcgta ccatgagcgt
    11341 caccggcctc gtgcacgccg tgagccccgc gcggcccgtc cgcaccatgc gcctcgctcg
    11401 ccttgtgcgc gccgttcata tagcggctgg agcgcatatg ccactcatgg ccgcccgact
    11461 gccagtcctg gagccccttg acgtaggcga ggacgcccgc acaggccgcc gggtccagct
    11521 cgtgctcggc gaagagcggg ccgagctcgg tgagcgcggt gtcctcgaac tgctggagcc
    11581 gcgaggtcag cagctcgttg acggagtcgg ccgcctcctg ggtggtgcag tccaggaacg
    11641 tctccaggac cagaacgcca ttgctgagct cgccctcttc ctcgatctcc cgctgatagg
    11701 agaacaggtc gttgcggagg tgcaccgcgt ccgcgaaggc gtcccgcagc acccgcatcg
    11761 gccgcgaccc ggcgatcacc gccggcacct cggcccgcac cgcatgctcg accagcccgg
    11821 ccgaccaggg cgcgccgccg accttacggc gcatctcgat gtactcgacc ggattgggca
    11881 cccggtcgat gttgatgttc gagagctccc agagcgattc gttgagcagg ttctcggtgc
    11941 tctcccggaa ccgggcccgc cagtccgacg acatggaggg caccgtccgc gcccacagat
    12001 ccgcgagccc cgcctcgacc gggttggtgg gctcgggggt cccgtcggcc ggatccatcg
    12061 gcatgaaggc gggcagccgg tcgagatacg ccttaccggc cgcacggtcc tgggagcgct
    12121 tgaacgtctc caggaagtgg tcgtcgaaga agaacaccca cacataccag tcggtgacca
    12181 gcgaaagctc cgtgccggag cagtcggggt gggtgtacgc gcacagcagg gcgtagtcgt
    12241 gggcgtcgag atcctcctgc tcccagatcc ccgagccctc gagcatttcc atctcgcggg
    12301 cccactgggt ggagtgctcc cgtgcctcct ggacatgggg gttcagccgc gccggatacg
    12361 gcatgtagaa atcggggagt cgaaagggct gtgtcactgc tgagccggca cctctccgtg
    12421 cgacggtggc ccgcagcggg acggctacgg accggggtcg gctacgggct acccatgccg
    12481 ctaccggcct atccgaaagc cccattagtc acacaagtgc gcgcctccca cccccggcgc
    12541 gccccctcgc cgcaaggtga ggaggcgcgc cgacggctca ttccgggccg tgggagcggc
    12601 cggccgcctg ggccccgacg ggcaccgcgg gggcggagcc accctgctcg gagggtccgc
    12661 cgccggatct tccggtcggc cggaaggccc actccatccg cggctccatc gcgaaccgga
    12721 acatccgctg gacgggtggt gtgcacaggg cggtcaccac ggccacggcc accgccgtca
    12781 ccacgatctc ccccagcggc cggtgcagcc acgggtggtc gtaccagtcc cagaagcggg
    12841 agcccttggc gaggaagccg tgcagcagat agccgtacag cgtcccggcg ccgagcaccg
    12901 tgaaccacat ccggcgccgg ggtacccagg cgaggaagca cacggtgagc accatggagc
    12961 agccgaagag ggcgaacgtc atcaccgtgc cgacccacca cggcgcaccg agctcctgcg
    13021 cgctgtcccg gcggtagaac cactccgggt tcatccgcgg tacggcccag taggcgaaga
    13081 ccagcgcggc ggcgaccacc ggcaccgaca gccgtctgac cgcgcgccgc cggatcatcc
    13141 ggaagtgctc cggccgcata tgcagcccca ccacgaagaa gggcaggaac tggagcaccc
    13201 gctggagatc gaggtcgtca ccgatgttcg gtgagcaggc ggcgagcgcg gcgacaccga
    13261 gagccagcgc caccggccac cgcacgatcc gccacagcgg tgtcgtcagc cgccagacga
    13321 agagcgcgat caggaaccag gtcagatacc aggggtcgag cagactgatc ggataggacg
    13381 gatcgtcgtc cgcccaccgc ttgaagaagg tgtacgcgac ctcgaagagg acgtacggga
    13441 cggcgatacc cgtgatcagt cgtttgagcc ggtccggccg gagatcgaaa ttccgggaga
    13501 agtacccgga gatgagaatg aacgccggca tatggaacgt gtagacggtc atatagagcg
    13561 cggacgccgc tctgctgccg ccgcgcaggg gctcccacgc atgccccatc gcgaccagca
    13621 cgatcgccag gtacttggcg ttgtcgaaga acgcgtcacg ttgtttcggc gcgggggacg
    13681 aggccggtgc ggcctcgggg ggcggggacg ccggtgcccg ccgcgcgggc agtaaggacg
    13741 agacgttcat cacatacagc ctcccgggga acctgcgggg gaaatcctgc ctctttccga
    13801 gtttcggcgg agggttgcgg agtggaacat tccatgcacc atagtggcgc ccgccgagcc
    13861 tcgccccaaa aggctcagct ctcgcgtaca agggtttacg cccagcccag cgcatccgtc
    13921 acctcctcga cttgggaact tgtttacctc tccgggtagt tcacagagtg acgaaggggg
    13981 ccgatccgcc ccgccttgac cggccccgcc tgctagcttc tacacaactg tagatcctaa
    14041 ccaccgtatg gagtgtgagt ggccatggcc ctgtgggacc gcatcaagga gtccgcccag
    14101 acgatgcaga ctcagctcgt ctcgaagaag aacgacttga agagcggtgc gttccgcgat
    14161 gcgagcatgg cgatgtgtgc cctggtggcg gcggcggacg gctcggtcga cccgtccgag
    14221 cggcagcgtg tcgcccagct gatcgccacc aacgaggtgc ttcagaactt cccggccgac
    14281 gacctacagc ggcgcttcaa cgactacgtc aacaagctca ccgcggactt cgagttcggc
    14341 aaggtgagcg tgatgcagga ggtcgccaag gccaagaaga agcccgccga ggcgcgcgcc
    14401 gtcgtccaga tcggcatcgt catcggcggc gccgacggca acttcgacaa gagcgagcag
    14461 gccatggtcc gcgaggcgtg ctacaccctg gacctcccgc ccgccgagtt cgacctctaa
    14521 gccgtaaggc ggtccggtaa accgtaaggc ggtcccgtaa gccccgaggc ggcctcacca
    14581 gccgtaaggc ggccctcaag ccattaggcc gcccgcagac cacaaagccg ccggccgcag
    14641 accgtagggg cgcggcctag agcggggtcg ccgcgtgcag gacgaggacc agggcgaccg
    14701 ccgcgttcgc cgaggacagc gcggacgcgg cggtgcccac cgccgctatc cacagggcca
    14761 gccccgccgc cgtccacgtc ggcggccagt gccggggtgg cggcaccggc cccagcagcg
    14821 ccgcgaccct gcgcggcacc ggccccggcg cggcgaaccc cgcgagcgcc ggccccggtg
    14881 tgccccgcga gaccagggcg gccttgccga ccgcccgcgc ggtgacccgg cggtcgccga
    14941 cctcccgggc cgcctcctcg tccgcccagc gctcggcgca gtagtccacc gcggcccgca
    15001 gcggccgcag cagcgggttg gcccgcgccg cgagctgcgc gcccagcaga tagcggtggt
    15061 ggtgcgcggt cagatgggcc cgctcatgcg cgatcagggc ccgccgctcg cgggtgctga
    15121 ggctgtccag catcccggtg gagacgacga tccggcccgg tttccccgtc cgcccggagg
    15181 tcccgggcag ggcgtacgca tacggcctgt cgtcgggcag caccgcgacc ggcgactccg
    15241 gcagcccggc gagcgcgagc caggcgttcc gccgcacccg cgagtgacgc agacaggtgg
    15301 ccgtacagga gacggccacc gctgccagcg cgccgatcgc cgccttcccg gccaccacgt
    15361 catagggcac cgcggcccgc acttcggggt ccgaccagct gtccggcagc ggattgcccg
    15421 gcagctgcgc cgtgccgacg accatcagca gccccaggca cagcgtggag cacaccgcga
    15481 ggacggtgcc gacgagcgtc agcagccggg tggcggtgcg cgggtggaga tgctgttcgg
    15541 cgagccgggc gatcggcagc gccgtcaagg gcagaaccag cgggaggaag acgaagacgc
    15601 ccatcggtca gccctccggc tcctccgcca cgtcgctcag caggtcgcgc agcagccgct
    15661 cgtcgtcctg ggtcagcccg gtcacaaagc tggccaggac cgcctcacgg tcgtcctggc
    15721 cgtccagcac ccggcgcatc cgcagcgccg cgagccccgc ctcgtccgac gccgcccgcc
    15781 agacgaagga gcggcccgcg cgttcacggg tcacggcctg cttggcgtgc agccgggaca
    15841 ggatggtcat gaccgtggtg taggcgagct cgccctcgat ccgctcctgc acccatgcgg
    15901 cggtcaccgg ccccggcgcc cggcgcagcg ccacgagcac ctgcgcctcc agttcgccct
    15961 ggccacgccg acgggggcgg cggggccagc cgggcccgcc ggtccggtcg tggtccgtca
    16021 caccgtctcc ttccacaccg cacgcgcccg gcgcgtggcg tttcatggta gcgagccgtg
    16081 gacggccgcc tccttcgccc ggaccacggc cgtccgttcg ccccattggc ctggctgtac
    16141 gcgcgacccc gggccgcctc gccgatgctg agcagtggga cgaccccgac gaaggaactc
    16201 actcagccat gacgcagacg caaggctcgc tcgtgcggca gatcaccgac tacgcgcatc
    16261 gtgcggaccc gtacccgctc tacgccgagc tgcgcaagac gcccgtggcg cacgacgagg
    16321 agggcccgta catcgtctcc acctactggg agatccacgg tctgctgcac gacccccggc
    16381 tcagctccga cgcccgcaac ctggaccccc gggccgcccc ggagctgatc gaggaggacg
    16441 gcgaggagga cgagccgggg ctgccgccca gcttcctgag gctggacccg cccgagcacg
    16501 accggctgcg ctccctcgcc atggcgccct tcggcccgcc gaacaccccg cgccggctcc
    16561 acaccatgcg cggtgagctc acgcgtatcg tcggcgagct gatcgacggc ttcgagggcc
    16621 gggaccggat cgatctcgtc gaccacttct cctacccctt cccggtgacc gtgatctgcc
    16681 ggctgctcgg ggtaccgcgg gaggacgagc cgcgcttcca cgcctgggcc gacaccgtcg
    16741 ccgccggtct ggaccccgac ccggacgcgg acgaggacgc cgccgagcgg cggcgggtca
    16801 gccggcaggc ccgtacggat ctggcggtgt atctgtccga gctgatcgag gagcgccgcc
    16861 gcgcacccgg cgacgacatg ctctcggccc tggtcggctg ggagggcccg gaggggcgga
    16921 tgagccgtgt ggagctgctg agcaccgcgg cgctgctgct ggtggcgggc catgagacca
    16981 ccgtcaacct gatcaccaac ggcatgctga ccctgctgcg caaccccgag gtgctcgcgc
    17041 ggctgcgcaa cgatccccat ctggtcgtcc cgctggtgga ggagttgctg cggttcgatc
    17101 cgccggtgca gatgcttccc cggcgcaccc cgctctccga gatcgacatc gcgggcgtga
    17161 ccatcccccg gggggcgtcc gtctggctgc tgctggcctc gggcaaccgc gatccgcagc
    17221 gcttcctcga ccccgatcga ttcgagcccc agcgcaggga caaccagcac ctcggcttcg
    17281 gcagcggcgt ccacagctgc ttcggcgcac cgctggcccg gctggaggcg cagatcgcgc
    17341 tgaccgagct ggcccgccgg ctggacgggc cccggctgct ggaggacccg ccgacctacc
    17401 ggcgcaacgc ggtgctgcgc gggccacggc atctgccgct cgccttcgag gggctgcggc
    17461 cgggcggatc cccgaacggg tcgcggtgac ggcggcgctc aggatggcgg cgaaggggtc
    17521 cgcggcgtgg ttcaccgcat acggaccgcg ggcgcactcc tcccgtccgc gcccttcccg
    17581 cccgtttccg tcccggcctc gtccttctcg gcccgggcgg cgatgttcct ggccattccc
    17641 ccgaagacga gggcgtggaa aggcgcgacc gaccaccagt agagatgccc ggccaggccg
    17701 cgcggatgga acagcgcccg ctgccggtac accgttcgcc cccgcccgtc cccgtcgacc
    17761 accatctcca gccatgccag gcccggcagc cgcatctcgg cccgcagccg cagcagccgg
    17821 ggcggccgga cctcctccac ccgccagaag tcgaggctgt cccccactct gagccgcgcc
    17881 gcgtctcgcc ggccccggcg cagccctacg ccgcccacca gggtgtcgat ccagccgcgc
    17941 agcgcccagg cgagcggcag cgaataccag ccgttctcac caccgatccc ctccaccacc
    18001 cgccacacgt cctcccgcga ggcgtccacc gcgcgctcgc gacggtcctg gtagaggctg
    18061 ccgcccgccc agtcggggtc ggtgggcagc ggatcgctgg gcgcgccggg ggtggcggcg
    18121 gaggaccagc gggtggccac atccgcgtcg cggatccgcc gcagggccag ctccagggcg
    18181 cggtccacgc cgagcggccc gcccggcgga tcgggcacat agcgggtgat gtcccgttcg
    18241 gcacacacca cctcatggcg cagcgactcc accagcgggc gggcgatggc gccgggcacg
    18301 ggggtgacca ggccgaccca cagactggac agcccggggg tgagcaccgg cacctgtgcg
    18361 atgaggcgcc gccgcagccc ggtcacctcc gcgtaccgct gcatcatggc gccgtaggtg
    18421 aggacgtcgg ggccgccgat gtcgaaggcc cggtgcacct cgtccggcag cgtggcgcag
    18481 cccaccagca gccgcagcac atcgcggacg gcgatcggct gggtgcgggt gcgcacccag
    18541 cggggcgtca ccatcagcgg cagccgctcg gtgagatagc gcagcatctc gaacgaggcc
    18601 gaacccgagc cgatgatcac cccggcccgc agaacggccg tcggcacccc ggagcccagc
    18661 agcacccgcc ctacctcggc ccgggaccgc agatggggtg agagcgcgcg ctcggggacg
    18721 ccgtacgggg tcagcccgcc gagatagacg atccggcgca cccccgcggc gcgggcccga
    18781 gcgccgaaga tccgggcggc gcggcggtcg gtctcctcga agccgggtcc ggtgcccagc
    18841 gcgtggacca ggtagtacgc gacgtccacg ccctccatgg cggcgcgcag ggactcctcg
    18901 tcggtcacat cgccgcgtac ggtctccacc cgcgccgccc aggggtggtc gcgcagcttc
    18961 tcgggggagc gggccacaca ccgcacctga tgccccgcgg ccagcagctc gggcaccagc
    19021 ctgccgccga tatagccggt ggccccggtg accagacagc ggcgcggctg cggcgcgtgg
    19081 tgcggctgcg gcgtgcggtg cggctcggat gcgcggtgcg gctccggcgg acgctcggga
    19141 agacccatga cgccatggtg cgcgggcagg acaaaacctg cgaggtgggc tcccttcggc
    19201 ggcattgtcc gtatcaggtg ttggaggtcg ctttccggtc tccccgacct tccagcctct
    19261 cagcccggcc atctaggaga cactccgggg gacttacgtc ctctgtcctg agcgtctctc
    19321 cggtcgagct ccctcgctcg ccccgcaggc tgttatttac gttactccga ccccccatga
    19381 gcgcctagcc cttttcgagc attttttcca gttttccggg ggccgcgggg cccgccccgg
    19441 gcccggcact agggctcctt ggctgcgccg ggaggggctg gcccggtagg ctttccgtgt
    19501 gatcttcaag cgcatcggaa acggtcggcc ctatcccgac cacggccggg aaagcacccg
    19561 ccagtgggcg gatgtcgccc cacgcccggt acgtcttgac cagttggtca cgacgaagca
    19621 gcagctcgac ctggagacgc tgctcgcgga ggactcgacg ttctacggtg acctcttcgc
    19681 ccatgtcgtg aaatggcagg gcgacctcta tctggaggac gggctgcacc gtgcggtgcg
    19741 cgccgcgctc cagcagcgcc aggtgctgca cgcgcgcgtc ctggagctcg agggctgacc
    19801 acgcccccgc gcgtcctccg gtgaccgatc gccgctgatc gacttccgat ctttgttggc
    19861 cctttcgggt tggtctgagc accaaccatt gatcatttag taggcatcgc cacctggccg
    19921 cactacgctg cgcacatgag catgctgacc cctcccggca tgggcggaaa gtaccgcatt
    19981 acgggcgatc gctacccgcg gatgagccga ccccggagcc gccggcgact ggtgttcgcc
    20041 tcgttcggct cggtcatggc gctcggcctg gtcggctggg gaacacttca gctcatcgat
    20101 gtcttctccg gcgacagcgg cgaccagaag gtccgcgcgg cgaacggcac cggggagtgc
    20161 gagcgcggcg acaagggccc cgccgagaac aacgcgaagt ccggccgggg cgacagcggc
    20221 caaggcggcc agggcggtca tggcggccgc acgggcggga agctgccgaa gccctcccag
    20281 atcacggtga acgtctacaa cgcgaccacg cgatccggcc tcgccaagga caccgccgag
    20341 gagctcgaga agcgcggctt caagatcggg aaagtgggca acgccccggc ccggtacgac
    20401 aagaaggtca agtcccccgg gatgctgctc ggcgcccccg gcgccggcga cggggccttc
    20461 aatgtgctcg gcacccagct caacggcgcc cagaccaaga acgacgcgcg cgacggcaag
    20521 gacatcgacc tgatcatcgg caacggtttc aaggacctgg tcaagcagaa ggacgccgac
    20581 aaggcgctga ccgccctggc caagccctcg cccacgccct ccggaacgcc ctgccactga
    20641 cctgcgccgc cactggcccg caccgggtgg gcgccgacct ggcgcgggtc actcggcgcc
    20701 ggccagatcg gcgccgagcc gggcgccgac caaccgagaa cccccttcaa gaggcgctca
    20761 gcccgcgtct tgagaggcgc tcagcccgcg gccccgtaca tccggtcacc cgcgtcgccg
    20821 agcccgggca cgatgtaccc ctgctcgttg agccgctcgt cgacggacga ggtgaccacc
    20881 gtcaccggcg cccccgcaag ctcgcgctcc atgagctcga cgccctgggg cgccgccagc
    20941 agacacagcg cggtcacatc gtcggcgccg cgcgatatca gctccctgat cgcggcgacc
    21001 agggtgccgc cggtggcgag catcgggtcc aggacgtaca cctgacggcc ggagaggtcc
    21061 tcgggcatcc gggtggcgta ggtggacgcc tggagcgtct cctcgtcccg gatcatgccc
    21121 aggaagccga cctccgcggt gggcagcagc cgcaccatgc cgtcgagcat cccgagaccg
    21181 gcccgcagga tgggcacgac catggggcgc ggatgggaca gccgcacccc ggtcgtggcc
    21241 gtcaccgggg tttcgatgtc gacctgctcg gtgcgcacat cgcgggtggc ctcgtacgcg
    21301 agcagggtca ccagctcgtc ggcgagccgc cggaaggtgg gggagtcggt gcgcttgtcg
    21361 cgcagcgtgg tgagtttgtg cgccaccagc gggtggtcga cgacgtggat ccgcatggca
    21421 atgacactaa ccgagccccc tgagcccggc tgtcgccggt gacccccttc cgcgcgcccc
    21481 cgccgcgctc gaccgtctgc cgccgtactg gcatcaaacc gccgattcgg gggaaagtgg
    21541 gcaggagcgc ccgggctgcc accgggcgat cacctcggcc ccgaggagtg atgtgaccat
    21601 ggccgacgcg accgcgatgg aaacctccgc ggaccgccgc cgccgtcgcg aacgcttcct
    21661 gcgcgcgctg aacgaggcca gggcggtacg gaaccaggtg cgtccccgcc aggcccgcgc
    21721 ggcccggatg cgccgtgcga tacacctgcg gacgttctcc tggtgagccc tggtgagttt
    21781 ccgccgaacc gccggagacg gtttccgcgc gtttcgattc cgtccgcgtg agccacatct
    21841 ctttggactg gtgcacgacg cagcgtggaa gacctctcgc gaagcgacgg tttctgccac
    21901 gattccgatt ggggcgggac actgtcccgc ccgcccccgg cacgcctatg accagtggga
    21961 gagtcacggt gtacttcgcc gcattgctcg cgcgcaccgc agaagggtgg gaagcgagcg
    22021 acacagagct cgatgacgtg gaaaccctga cggatctgat cgaactggcc cgtctggccg
    22081 cgaaggatga cgacacggta ttggcgttca tcgagcacga agacgcgtgg ttcggcgtcg
    22141 tccgcgtgga cggcgaggac gacccgcaca tctatgtatc ggacgcggca gcggccgccc
    22201 gcacctcgta cggctcgatg ctcaccgacg agttgctggg ccgggacccc gacgacgatc
    22261 tggacagcct ggtcgacctg gacggcaccg aggacggcga gccggaccgg gacgacgagg
    22321 acgccgacga cgccccggtc ccgatcggcc cgctcggcga cgccgacatc ctggccgacc
    22381 tcggcatgga cgagaag
//
