LOCUS       NZ_CP019458            12397 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces autolyticus strain CGMCC0516 chromosome, complete
            genome.
ACCESSION   NZ_CP019458
VERSION     NZ_CP019458.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces autolyticus
  ORGANISM  Streptomyces autolyticus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10029028)
  AUTHORS   Yin,M., Jiang,M., Ren,Z., Dong,Y. and Lu,T.
  TITLE     The complete genome sequence of Streptomyces autolyticus CGMCC 0516,
            the producer of geldanamycin, autolytimycin, reblastatin and
            elaiophylin
  JOURNAL   J Biotechnol 252, 27-31 (2017)
   PUBMED   28472671
REFERENCE   2  (bases 1 to 10029028)
  AUTHORS   Yin,M., Jiang,M. and Lu,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2017) Yunnan University, Yunnan University, 2#
            Cuihu Beilu, Kunming, Yunnan 650091, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Analysis v. 2.3.0
            Genome Coverage                   :: 279x
            Sequencing Technology             :: Illumina; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 03:05:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,227
            CDSs (total)                      :: 8,141
            Genes (coding)                    :: 7,920
            CDSs (with protein)               :: 7,920
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 221
            CDSs (without protein)            :: 221
            Pseudo Genes (ambiguous residues) :: 0 of 221
            Pseudo Genes (frameshifted)       :: 74 of 221
            Pseudo Genes (incomplete)         :: 182 of 221
            Pseudo Genes (internal stop)      :: 9 of 221
            Pseudo Genes (multiple problems)  :: 42 of 221
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:31:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4575325
            Orig. end                         :: 4587722
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP019458.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..12397
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="25"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..12397
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12397
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:7397](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7397
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(278..985)
                     /locus_tag="BV401_RS17960"
                     /old_locus_tag="BV401_17990"
     CDS             complement(278..985)
                     /NRPS_PKS="Domain: PKS_KR (9-94). E-value: 1.7e-07. Score:
                     23.2. Matches aSDomain:
                     nrpspksdomains_BV401_RS17960_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060942.1"
                     /locus_tag="BV401_RS17960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_17990"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_079257769.1"
                     /transl_table=11
                     /translation="MLDLGLEGRTVLVTGATGAIGRAAARAFAEQGARVALAFRHRREA
                     AEALADELSGSDRGRAFAVPYALDDAASPRWVVAAVEERWGGLDVLVATARRRGARREP
                     HTRFEDVPEEHWRPLVTDGFAPAIRTVQWSLAGMRKRGWGRIALVAAPYAADGDSGGEF
                     HAVARAGLHGLVRGLMDEVGGDGVLINAVCPGPTPPDRPPTTPEDIARTLLFLCSAANG
                     TVTGEALTLAGRR"
     aSDomain        complement(704..958)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BV401_RS17960_PKS_KR.1"
                     /evalue="1.70E-07"
                     /label="BV401_RS17960_PKS_KR.1"
                     /locus_tag="BV401_RS17960"
                     /protein_end="94"
                     /protein_start="9"
                     /score="23.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="TVLVTGATGAIGRAAARAFAEQGARVALAFRHRREAAEALADELS
                     GSDRGRAFAVPYALDDAASPRWVVAAVEERWGGLDVLVAT"
     CDS_motif       complement(884..958)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BV401_RS17960_0001"
                     /evalue="8.50E-09"
                     /label="PKSI-KR_m1"
                     /locus_tag="BV401_RS17960"
                     /protein_end="34"
                     /protein_start="9"
                     /score="28.0"
                     /tool="antismash"
                     /translation="TVLVTGATGAIGRAAARAFAEQGAR"
     gene            complement(1129..2079)
                     /locus_tag="BV401_RS17965"
                     /old_locus_tag="BV401_17995"
     CDS             complement(1129..2079)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060943.1"
                     /locus_tag="BV401_RS17965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_17995"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_069863907.1"
                     /transl_table=11
                     /translation="MHTVVILALDQVIPFDLATPIEVFTRTRLPDGREPYRVRVCGPTP
                     TIDAGVFALQAPYGLEALAEADTIVVPGRSDPLLPVPAEVNDALRDAAGRGTRIASICS
                     GAFTLAATGLLDGHCATTHWLGGALLAELHPKIQVDPDVLYVDNGQFLTSAGAAAGLDL
                     CLHIIRRDHGSAVAADAARLSVMPLEREGGQAQFIVHDQPPVPRGSLFEPLLRWMEDNA
                     ARDLTLTEIATHAGMSTRTLNRRFREHTGTTPLQWLHRARIRQAQYLLEATTHPVERIA
                     TQVGFGSPTSFRDRFKRVVGTSPHSYRSAFRRNAG"
     gene            complement(2170..3405)
                     /locus_tag="BV401_RS17970"
                     /old_locus_tag="BV401_18000"
     CDS             complement(2170..3405)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060944.1"
                     /locus_tag="BV401_RS17970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_18000"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_069863905.1"
                     /transl_table=11
                     /translation="MMREIDTDVCVVGGGPAGLVLALLMLRSGARVTVLECARAHQRVV
                     RGEILQPGAMELLDALDVLSGARARGAHEHHRFLVMEGERVLLEADYRLLPAPYDHLLS
                     VPRPHLLDELLARCRRSPGFRYLPGRRAGGLLRRDERIAGVIADGPPGRCAVRARVVVG
                     ADGRFSRVRRLAGIGAGRAEAFAQDVLWCALTASPEEPPVRDVRVFRTGGGPVLVYGSW
                     PNRIQIGWTLPHRRYGHLAALGLDHVKERLVRAVPRYATLIRDQIRTPADLGVLDVFSA
                     RAERWAADGLVLIGDAAHTHSPIGAQGINLAVQDAVVLHPLLTRALAEGDTSAERLAEF
                     ERRRGPDIAAVMRMQTLQSRAILSQGAFTTRVRPRLARALRRTPLYRKILQRMAYGNPS
                     IRIADAGVCGRT"
     misc_feature    complement(3690..3708)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.56"
                     /tool="antismash"
     misc_feature    3712..3726
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.62"
                     /tool="antismash"
     gene            complement(3731..4555)
                     /locus_tag="BV401_RS17975"
                     /old_locus_tag="BV401_18005"
     CDS             complement(3731..4555)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060945.1"
                     /locus_tag="BV401_RS17975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_18005"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_030836626.1"
                     /transl_table=11
                     /translation="MDIKVLGPLSVEACGQSIVPSAGKPRQILALLSVYANQMLPVPTL
                     MEEIWGTQMPRSALTTLQTYILQLRRRLAAAYGPQAPQASKDVLATRYGGYVLEAQPGA
                     VDIHEYDRLVAAGREALDAGDDVQASLLLREALAVWRGPALVDVKVGPVLEIELARLEE
                     SRLGVLERRIEADLRLGRHAELLTELTELTARHPLHEGLHAQCMAALYRAGRPWQALEV
                     YQGLRARLVEDLGLEPSPRLQKLQQAVLASDPALDLDLDGHWRRPVLDLFAA"
     misc_feature    complement(4674..4688)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.49"
                     /tool="antismash"
     gene            4739..4993
                     /locus_tag="BV401_RS17980"
                     /old_locus_tag="BV401_18010"
     CDS             4739..4993
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BV401_RS17980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BV401_18010"
                     /product="hypothetical protein"
                     /protein_id="WP_079257770.1"
                     /transl_table=11
                     /translation="MTDTPVPNESTSPACLAYSAENTEVTGVAEITERVRFAARAGAVG
                     AAETVHPPVEADDLVIEDLSEAVWAVPAAGICICTVGAE"
     gene            5001..7397
                     /locus_tag="BV401_RS17985"
                     /old_locus_tag="BV401_18015"
     CDS             5001..7397
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cyanobactin_D_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Goadsporin_CD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NHLP_CD_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060947.1"
                     /locus_tag="BV401_RS17985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_18015"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_079257771.1"
                     /sec_met_domain="Cyanobactin_D_RRE (E-value: 6.4e-12,
                     bitscore: 44.2, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="Goadsporin_CD_RRE (E-value: 1e-17,
                     bitscore: 62.9, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="NHLP_CD_RRE (E-value: 8.3e-15, bitscore:
                     53.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 1.9e-81, bitscore: 273.2,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 6.6e-70, bitscore:
                     234.7, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGELGFTPHLRVEPVPGEAVYLVSEHGVTALHGQAIAALAPLLD
                     GSRDLAHILTEAAAPARATGPAGAVPAGQAERVIARLRAAGLVSERKRASTPEAAYWEL
                     AGPTAVGGPTPAPAPRASRPAVAPLVLGSADPGEVVRALRAAGLRTAASRTVGGAAADR
                     GAVDGDPTVSGAGTPRREICQIAPRQHGDTELTLVVCDDYLDPRLAAVDAAHRAAGLRW
                     LPVKPVGTQAWLGPFLGAPDDPCWVCLADRLWRGRQAEAYLQRRLGRPGPVPRPPASLP
                     ASRAAALQLAALEAAKWLAGHRHPGQRELRTLDSLTATVDRHPLARRPQCVGCGDPALV
                     SARIRAPLSLPSPRDPLIGTDADTSPRGIVDTSPRGIMERYGHLVDPVTGLVTEIRRDP
                     RGPAVLNCFHARHPSYAGAGPHSGLDAVRAGLRAAAHGKGRTAEQARASALCEALEHYS
                     GHFQGDEPRQRARYRDLRPDDAVHPDTVQLFDPRQFRDPALPARHRINDPFDEGAELDW
                     TPVWSLTAERHRLLPTALLYYGAPQPPGGRCCRADSNGAAAGGTLADAVVRGFLELVER
                     DAVALWWYNRTRQPAVALDAFDDPWLTEVRAAHRGVRREVWALDLTTDFGIPVVAALSR
                     RLDKPAEDITLGFGAHFDRHTALCHAFAELNQMLPAVVEARADGGGYGAAEPEALRWFR
                     TATLADHPYLTPDPAAPPPPISGPPEGDATTAVRELARGRGMELLVLDQTRPDVGLPVA
                     KVLMPGMRPHWARFAPGRLFDVPVALGRLSAPTPYADLNPIPFFL"
     aSDomain        5010..5264
                     /aSDomain="Cyanobactin_D_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing D protein in a cyanobactin
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BV401_RS17985_Cyanobactin_D_RRE.1"
                     /evalue="2.20E-14"
                     /identifier="RREFam007.1"
                     /label="BV401_RS17985"
                     /locus_tag="BV401_RS17985"
                     /protein_end="88"
                     /protein_start="3"
                     /score="44.2"
                     /tool="antismash"
                     /translation="ELGFTPHLRVEPVPGEAVYLVSEHGVTALHGQAIAALAPLLDGSR
                     DLAHILTEAAAPARATGPAGAVPAGQAERVIARLRAAGLV"
     aSDomain        5010..5309
                     /aSDomain="NHLP_CD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing CD fusion protein in a
                     NHLP/Nif11 LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BV401_RS17985_NHLP_CD_RRE.1"
                     /evalue="2.90E-17"
                     /identifier="RREFam015.1"
                     /label="BV401_RS17985"
                     /locus_tag="BV401_RS17985"
                     /protein_end="103"
                     /protein_start="3"
                     /score="53.5"
                     /tool="antismash"
                     /translation="ELGFTPHLRVEPVPGEAVYLVSEHGVTALHGQAIAALAPLLDGSR
                     DLAHILTEAAAPARATGPAGAVPAGQAERVIARLRAAGLVSERKRASTPEAAYWE"
     aSDomain        5010..5318
                     /aSDomain="Goadsporin_CD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing CD fusion protein in a
                     goadsporin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BV401_RS17985_Goadsporin_CD_RRE.1"
                     /evalue="3.60E-20"
                     /identifier="RREFam013.1"
                     /label="BV401_RS17985"
                     /locus_tag="BV401_RS17985"
                     /protein_end="106"
                     /protein_start="3"
                     /score="62.9"
                     /tool="antismash"
                     /translation="ELGFTPHLRVEPVPGEAVYLVSEHGVTALHGQAIAALAPLLDGSR
                     DLAHILTEAAAPARATGPAGAVPAGQAERVIARLRAAGLVSERKRASTPEAAYWELAG"
     misc_feature    5022..5036
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 19.88"
                     /tool="antismash"
     misc_feature    7414..7427
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.07"
                     /tool="antismash"
     gene            7536..8774
                     /locus_tag="BV401_RS17990"
                     /old_locus_tag="BV401_18020"
     CDS             7536..8774
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060948.1"
                     /locus_tag="BV401_RS17990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_18020"
                     /product="histidine kinase"
                     /protein_id="WP_231981439.1"
                     /transl_table=11
                     /translation="MPDGAGNHPPRHHDDLAPRLAVVITVIVLVGYFSVAVTYVVDGNR
                     SGGTIDAAMLALALLPMTVLLCLQMLHSFPGLAPRLSRARHWTLALQAVLTFAPFAIFK
                     HAWLGMPGFLAGSSLLVLVPALAWPAFAAILLCTDVLLFQVGFGWGQVAYTSVSTALTG
                     LVVFGLSRLSGLVAEVSRSRAELARLAVAQERLRFSRDVHDLLGYSLSTITLKCELVHR
                     LVPRQNSRAQQELSEILQTSRQALADVRAVASGYRKMSLSAEAATARSMLAAAGISATA
                     EIDCAPLPELVDTVLASVLREGLTNVLRHSKADHCAFEARRSGHRVWLTLVNDGVGRPS
                     TILRADSTDGGSGIGNLRVRVENLGGRLRAGVRSDGWFELRAELDVSVAAPRRSGRERG
                     SEEEYGPGPTVTA"
     misc_feature    7562..7582
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.94"
                     /tool="antismash"
     misc_feature    8673..8675
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8885..9490)
                     /locus_tag="BV401_RS17995"
                     /old_locus_tag="BV401_18025"
     CDS             complement(8885..9490)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009717663.1"
                     /locus_tag="BV401_RS17995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_18025"
                     /product="response regulator transcription factor"
                     /protein_id="WP_079257772.1"
                     /transl_table=11
                     /translation="MVRVLIAEDMHMLRKALVALLEFEPDIEVVAEFPDGADILPRARE
                     LRPDVAVLDIDLPGMDGLTAAAELSTAVPECRTMMLTSLGRPGNLRRALAAHVSGFLLK
                     DSSPEKLSDAIRAVAKGERVIDPQLALAALDDGPQPLTPRELEVLRFAAKGEDSGQIAA
                     KLFLSVGTVRNYLTSAVTKLDARNRVDAIRIAREAGWL"
     misc_feature    9525..9540
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.87"
                     /tool="antismash"
     misc_feature    9664..9673
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            complement(9718..10986)
                     /locus_tag="BV401_RS18000"
                     /old_locus_tag="BV401_18030"
     CDS             complement(9718..10986)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060950.1"
                     /locus_tag="BV401_RS18000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_18030"
                     /product="M6 family metalloprotease domain-containing
                     protein"
                     /protein_id="WP_079257773.1"
                     /transl_table=11
                     /translation="MVRPQVPEGVHQQPRLRRTQALLTSLSALIATTVVAGPAVAAGPG
                     GPCDLERTDAHHSEGLDTWNSRYPRPVRRLDAAMVFLSFPDARPRVTPARLAADHIPAT
                     PDFFKRASYGKFALRVHPLRRWIAMPQRSTAYAIQRDWNAQRRAAYLRDAIASADPHLD
                     FGRYDLVYLVADPDAPGVDADATKVVNFEKPLRADGVDLRRLVTVFEHHPPDRNVLAHE
                     TGHVFDLPDLYHRPKDTDGNAEWDTYVGDWDLMGSQFGMAPDPFGWHKWKLGWLGARQV
                     ACDRLTGPRRYTLQPLSAPMARGGPGADFRTRLVVVRTGPTTALAIEARGGRGNDAGTC
                     TEGVLVYRVHNDKASGDGPVQVLDGHPTTSACWNESVYPELADAPLGVGDTLSVKEDDV
                     RITVAGRAADGGWTVRVNRQAPG"
     misc_feature    complement(11411..11424)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.81"
                     /tool="antismash"
     misc_feature    12075..12089
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
ORIGIN
        1 caccgccatg ggcagggcgc agatctgcac cggcaccagg ccggcgcggg cgacggccgc
       61 cgcgcatgcg gacggcaccg cgacccgcac ctggtgcccg gcctcgagca gggcgcgcgc
      121 cagcggcacc atggggacga gatgggcgcc cgaggcccag gtcgtgaaca ggacgcgcac
      181 ggtgacctcc cgcggagtcg agccggccgg accgccccgt ccggccgatg gacatgacac
      241 cgagccgact catcgcatcc cgcgctcctc ggcgggctca gcggcgcccc gcgagcgtca
      301 gcgcttcgcc ggtgaccgtg ccgttggccg cggagcacag gaagaggagg gtgcgggcga
      361 tgtcctcggg ggtggtgggc ggccggtcgg gcggggtggg cccggggcat acggcgttga
      421 tcagcactcc gtcgccaccc acctcgtcca tcagaccgcg gaccagaccg tgcagcccgg
      481 cccgcgccac cgcgtggaac tccccgccgg aatcgccgtc cgccgcgtac ggcgcggcca
      541 ccagcgcgat ccggccccag ccgcgcttgc gcatcccggc gagggaccac tggacggtgc
      601 ggatcgcggg cgcgaagccg tcggtgacca gcggccgcca gtgctcctcc ggcacgtcct
      661 cgaaccgggt gtgcggctcg cgtcgcgcgc cccttcgccg ggcggtcgcc accagcacgt
      721 ccagcccgcc ccagcgctcc tccacggcgg ccacgaccca gcgcggcgac gcggcgtcgt
      781 ccagggcgta cggcacggcg aaggccctgc cccggtcgga tccggacagc tcgtcggcca
      841 gcgcctcggc ggcctcgcgg cggtgccgga aggcgagcgc gacccgggcg ccctgctccg
      901 cgaaggcgcg cgcggcggcc cggccgatgg ccccggtggc cccggtgacc aggaccgtgc
      961 gcccctccag gccgaggtcc aacatgggca ctcctcgcgg tcgttcccac tgagaaggcc
     1021 atggtcgccg ccgtgactcg aggcagcctc gactcgcgcc cgcccctgcc gggatgtggc
     1081 ggccgtccgg cgttcgccga acggcttccg gcgtttcgca gaagcggctt atccggcgtt
     1141 tcgccggaag gcggagcggt agctgtgcgg gctggtgccg acgacacgct tgaagcggtc
     1201 ccggaaggag gtgggcgagc cgaagccgac ctgggtggcg atgcgctcga ccgggtgggt
     1261 ggtggcctcc agcagatact gcgcctggcg gatcctggcg cggtgcagcc actggagcgg
     1321 ggtggtcccg gtgtgctccc ggaagcggcg gttgagggtg cgggtgctca tgccggcatg
     1381 ggtggcgatc tcggtgaggg tgaggtcccg cgcggcgttg tcctccatcc accgcagcag
     1441 gggttcgaac agcgatccgc gcggtacggg cggctggtca tggacgatga actgggcctg
     1501 cccgccctcc cgttccaggg gcatcacgga cagccgggcg gcgtcggcgg ccacggcgga
     1561 accatggtcg cgccggatga tgtgcagaca gagatcgagc ccggccgcgg cgcccgccga
     1621 ggtgaggaac tggccgttgt ccacatagag cacatccggg tcgacctgga tcttcggatg
     1681 gagctcggcg agcagcgcgc cgccgagcca gtgtgtggtg gcgcagtgcc cgtcgagcag
     1741 cccggtggcg gcgagggtga aggccccgga gcagatcgag gcgatacggg tgccccgccc
     1801 ggccgcgtcc cgcagcgcgt cgttcacctc ggcggggacc gggagcaggg ggtcgctacg
     1861 gccgggcacg acgatggtgt cggcctcggc gagcgcctcg agcccgtacg gcgcctggag
     1921 ggcgaacacc ccggcgtcga tggtgggggt gggcccgcag acccggaccc ggtagggctc
     1981 gcggccatcg gggagccggg tgcgggtgaa cacctcgatc ggggtggcca gatcaaaggg
     2041 gatcacctga tccagcgcca ggatcacgac agtgtgcatg gcctcaacct aggccgtacg
     2101 gcctatggca ccaccgtcgg ggtggcgaga agccggtcca cccacgaatt ccggccaccg
     2161 cgcttcgggt catgtccggc cgcacactcc ggcgtcggcg atacggatcg acggattgcc
     2221 gtaggccatg cgctggagga tcttgcgata gagcggtgta cgacgcagcg cccgcgcgag
     2281 acgggggcgc acccgggtgg tgaacgcgcc ctgcgagagg atcgcccggc tctgcaaggt
     2341 ctgcatccgc atgaccgccg cgatatcggg cccgcgccgc cgctcgaact ccgccagccg
     2401 ctcggcgctg gtgtcgccct cggccagggc acgggtcagc agggggtgca gcaccaccgc
     2461 gtcctgcacc gcgaggttga tgccctgggc gccgatcggg ctgtgggtgt gggccgcgtc
     2521 gccgatcagc accagaccgt cggcggccca gcgctcggca cgggcggaga agacatcgag
     2581 cacaccgaga tcggccgggg tccggatctg gtcgcggatc agcgtggcgt accgcggcac
     2641 ggcgcgcacc agccgctcct tgacatggtc gaggccgagg gcggccagat ggccgtagcg
     2701 ccggtgcggc agggtccagc cgatctggat ccggttcggc caggagccgt agaccagcac
     2761 cgggccgccg ccggtgcgga acacccgcac atcgcggacc ggcggctcct ccggggacgc
     2821 ggtgagcgcg caccacagga catcctgggc gaacgcctcg gcgcggcccg ccccgatgcc
     2881 cgccagccgc cggacccgcg agaaccggcc gtccgcgccg accacgaccc gcgcccgtac
     2941 ggcacaacgg cccggaggtc cgtcggcgat caccccggcg atccgctcat cccgccgcag
     3001 cagaccaccg gcccgccgtc cgggcagata gcggaagccg ggcgagcggc ggcagcgggc
     3061 gaggagctca tccagcagat gggggcgcgg aacgctcaac aggtggtcgt acggggccgg
     3121 aagcaaccgg tagtcggcct ccagcagcac ccgctcgccc tccatcacca ggaaccggtg
     3181 gtgttcatgg gcgccgcggg cgcgggcgcc ggagagcaca tcgagcgcgt ccagcaactc
     3241 catcgcgccg ggctggagga tttcgccgcg gaccacgcgc tgatgcgcgc gggcgcactc
     3301 caggacggtc acccgggccc ccgaccgcag catcagcagc gccagcacca gaccggccgg
     3361 gccgcccccg accacgcaca catcggtgtc gatctcgcgc atcatcgcgc ctcctgctgg
     3421 tcgggctcca gggcctgggc accgggcgcc agtgacaccc cctgacgctc cctggacgcg
     3481 ctacggctcc gcttgcccgc gcggggggat cgggcagcgg agccgtagca ggcccggctg
     3541 aagggcggcg ccgggcgttt ttggggggat ggttcatcgg acggggacgg ctggtacggg
     3601 acctacgaga cctgtgggaa ccggacccac gagacttcgg acgagggcgg tatcagggat
     3661 cgactgtcgg ctgtcggctg tagctgtcgg ctgtcggtct attcggtcga gggactatgc
     3721 ggtcgaggga ctatgcggcg aacaggtcga gcacagggcg gcgccagtgg ccgtccaggt
     3781 ccagatcgag cgccgggtcg gaggcgagca ccgcctgctg gagcttctgg agccgcggcg
     3841 acggctccag cccgaggtcc tcgaccagcc tggcgcgcag tccctggtag acctccagcg
     3901 cctgccaggg gcggcccgcg cggtagagcg cggccatgca ctgggcgtgc agcccctcat
     3961 gcagcggatg gcgggccgtc aactcggtga gctcggtgag cagctcggca tggcggccca
     4021 ggcgcagatc ggcctcgata cggcgctcca ggacgccgag ccggctctcc tccagacggg
     4081 ccagctcgat ctccagaacc ggcccgacct tcacatccac cagcgcgggg ccgcgccaca
     4141 cggccagcgc ctcgcgcagc agcagggacg cctgcacatc gtccccggcg tccagcgcct
     4201 cccgccccgc ggccaccaac cggtcgtact catggatgtc caccgcaccc ggctgggcct
     4261 ccagcacata tccgccgtag cgcgtcgcca gcacatcctt ggatgcctgc ggggcctgcg
     4321 ggccataggc ggcggccagc ctgcggcgca gctggagaat gtaggtctgc aaagtggtga
     4381 gcgcgctgcg tggcatctgt gtgccccaga tttcctccat aagagtgggc accgggagca
     4441 tctggttggc gtagacggaa agcaatgcaa ggatctggcg cggcttgccc gcgctcggca
     4501 cgatcgactg accgcacgcc tcgacgctca gcggccccaa caccttgatg tccatggtcg
     4561 tgtacctccg tcaacggtcc gtcaagtgcc tcctggccgc gcggccctgc caccgaggca
     4621 tctaagagcc tcgcttgtgg gcggcctgtg cggccagtgc cggagtaacg agctcgatat
     4681 gagttccaga gccccgcacc atgacaaatt cacacccctg gcgatgagag agtccgcgat
     4741 gaccgatacg cccgtcccaa atgagtccac gagccccgcc tgcctggctt attccgccga
     4801 gaacaccgag gtcaccgggg tcgccgagat caccgaacgc gtcaggttcg ccgcgcgcgc
     4861 cggggccgtc ggggccgccg agaccgttca tccgcccgtc gaggcggacg acctggtcat
     4921 cgaggacctc tccgaggccg tctgggccgt ccccgcggcc ggcatctgca tctgcaccgt
     4981 cggcgccgaa tgaccggccg atgaccggcg aactgggctt cacaccacat ctgcgggtcg
     5041 agccggtgcc gggcgaggcc gtgtatctcg tttccgagca cggggtcacg gcgctgcacg
     5101 ggcaggcgat cgccgcgctg gcgccgctgc tcgacgggtc gcgggacctc gcccacatcc
     5161 tcaccgaggc cgccgcgccc gcccgcgcca cgggcccggc cggcgcggtc ccggccgggc
     5221 aggccgagcg cgtcatcgcc cgcctccgcg cggccgggct ggtctccgag cggaagcgcg
     5281 cctcgacccc cgaggcggcg tactgggagc tggcggggcc gaccgccgtg ggcggcccca
     5341 ccccggcgcc cgcgccccgg gcgtcccgcc ccgccgtggc cccgctggtc ctcggctcgg
     5401 ccgatccggg cgaagtggtc cgggcgctgc gcgccgcggg gctgaggacc gctgcctcga
     5461 ggaccgtggg cggggccgcg gcggaccggg gggcggtgga cggcgatccg acggtttccg
     5521 gggccggtac tcctcgccga gagatatgtc aaatcgcccc tcgtcaacat ggcgacacgg
     5581 aactcaccct tgtggtgtgc gatgactacc tcgatccccg gctcgccgcc gtggacgccg
     5641 cgcaccgcgc cgccggcctt cgctggctgc ccgtcaaacc ggtgggcacc caggcgtggc
     5701 tgggcccgtt cctcggcgcc cccgacgatc cgtgctgggt ctgtctggcc gaccggctgt
     5761 ggcgcggacg gcaggccgag gcgtatctcc agcgccggct cggccgcccg gggccggtgc
     5821 cgcgcccgcc cgcctccctg cccgcgagcc gcgccgcggc gctccagctc gccgccctgg
     5881 aggccgccaa gtggcttgcc gggcaccggc atccgggcca gcgagagctg cgcaccctgg
     5941 acagcctcac cgccaccgtg gaccgccatc cgctcgcccg ccggccacag tgcgtcggct
     6001 gcggcgaccc ggcgctggtc tcggcccgga tacgggcgcc cctgtcgctg ccgtcgccac
     6061 gggacccgct catcggcacc gacgccgaca cctccccgcg cgggatcgtc gacacctccc
     6121 cgcgcgggat catggagcgc tacggacatc tggtggaccc cgtcaccgga ctggtcaccg
     6181 agatccggcg cgatccgcgc ggcccggccg tcctcaactg cttccacgcc cgccacccct
     6241 cgtacgccgg tgcgggcccc cacagcggtc tggacgccgt aagggcgggg ctgcgggccg
     6301 ccgcccacgg taagggccgc acggccgaac aggcgcgggc gagcgcgctg tgcgaggccc
     6361 tggagcacta cagcggccat ttccaggggg acgagccccg tcagcgcgcc cgctatcgcg
     6421 atctgcgccc ggacgacgcg gtgcatccgg acaccgtcca gctcttcgat ccgcggcagt
     6481 tccgggaccc cgccctcccc gcgcgccacc ggatcaacga tccgttcgac gagggcgcgg
     6541 agctggactg gaccccggtg tggtcgctca ccgccgaacg ccaccggctg ctgcccaccg
     6601 cgctgctgta ctacggcgcc ccgcaacccc cgggcggccg ctgctgccgg gcggactcca
     6661 acggcgcggc ggccggcggc actttggccg acgccgtcgt acggggcttt ctggagctgg
     6721 tggagcggga cgcggtcgcc ctgtggtggt acaaccgcac ccggcagccc gccgtggccc
     6781 tcgacgcctt cgacgacccc tggctgaccg aggtgcgcgc cgcccaccgg ggcgtgcggc
     6841 gcgaggtgtg ggccctggac ctcaccacgg acttcggcat tccggtggtc gccgcgctct
     6901 cccggcgcct cgacaagccc gccgaggaca tcaccctcgg cttcggcgcc cacttcgacc
     6961 ggcacaccgc gctctgccac gccttcgccg agctcaacca gatgcttccg gcggtggtcg
     7021 aggcccgtgc cgacggcggg ggctacggcg cggccgagcc cgaggcgctg cgctggttcc
     7081 gcaccgcgac cctcgccgac cacccgtatc tgacacccga tccggccgcc ccgccgcccc
     7141 cgatatccgg ccccccggag ggcgacgcga cgaccgccgt aagggagttg gcgcgcgggc
     7201 gcgggatgga gctgctggtg ctggaccaga cccggccgga tgtgggactg ccggtggcca
     7261 aggtgctgat gcccgggatg cgcccgcact gggcccggtt cgcgcccggc cggctcttcg
     7321 acgtacccgt cgcgctcggg cggctgtcgg cccccacgcc ctatgcggac ctcaacccga
     7381 ttccgttttt cctgtgattc cccgtgacac ccggtaactc tgcgtacacc atgagccttc
     7441 tacgcggcct ctccacctcc accgaagatc ggatactctc gggcaagcca cccaatccgg
     7501 ctcgaccatc cggaggacga gtgcagggga gcctcttgcc cgacggtgcc gggaaccacc
     7561 caccgcgtca ccatgacgat ctggcgccgc gtctggccgt ggtcatcacg gtcatcgtgc
     7621 tggtgggcta cttctccgtg gccgtcacct atgtggtcga cggcaatcgt tcgggcggga
     7681 cgatcgacgc ggcgatgctc gcgctggcgc tgctgccgat gaccgtcctg ctctgcctcc
     7741 aaatgctgca ctccttcccc ggcctcgcgc cccggctcag ccgcgcccgg cactggacgc
     7801 tggcgctcca ggcggtgctg accttcgccc cgttcgcgat cttcaagcac gcctggctgg
     7861 gcatgccggg cttcctggcc ggctcctcgc tgctggtgct ggttccggcg ctggcatggc
     7921 ccgcgttcgc ggccatcctg ctgtgcacgg acgtgctgct gttccaggtc ggcttcggct
     7981 ggggccaggt cgcgtacacc tcggtctcca ccgcactgac cgggctggtg gtcttcgggc
     8041 tctcgcggct gtccgggctg gtcgccgagg tgtcccggtc ccgggcggaa ctggcccggc
     8101 tggcggtcgc ccaggagcgg ctgcggttct cccgggatgt gcacgatctg ctgggctaca
     8161 gcctctccac gatcaccctc aaatgcgagc tggtgcaccg gctggtgccc cggcagaact
     8221 cccgcgccca gcaggagctc tcggagatcc tccagacctc ccgtcaggcc ctcgccgacg
     8281 tacgggccgt ggccagcggc tatcgcaaga tgtcgctgtc ggcggaggcg gccacggccc
     8341 gctcgatgct ggccgcggcg ggtatcagcg ccacggccga gatcgactgc gcaccgctgc
     8401 cggagctggt ggacacggtg ctggcgagcg tgttgcgcga ggggctgacc aatgtgctgc
     8461 gccacagcaa ggccgaccac tgcgcgttcg aggcacggcg cagcggccac cgggtgtggc
     8521 tgaccctcgt caacgacggg gtcggccggc cgtccacgat cctgcgcgcc gacagcacgg
     8581 acggcggcag cggaatcggg aacctccggg tgcgggtgga gaacctcggc gggcggctgc
     8641 gcgcgggcgt gcggtcggac ggctggttcg agttacgggc ggagctggat gtgtccgtgg
     8701 ccgcgccgcg gcggagcggc cgggagcgcg gctcggagga ggagtacggc ccggggccga
     8761 ccgtgacggc gtgacagggg cccgtggcgg cgtcacaagg cccggggcgg cgtggcccgc
     8821 gacgcgcggc gagaaccggg gcggcgcggc gagacagtgg ccgcgaggca aggcccggtc
     8881 gccgctacag ccagcccgcc tctcgggcga tccggatggc gtcgacgcgg ttgcgggcgt
     8941 ccagcttggt cacggcggac gtcaggtagt tgcgcaccgt gcccaccgac agaaacagct
     9001 tggccgcgat ctgcccggag tcctccccct tcgcggcgaa ccgcagaacc tccagctcac
     9061 gtggggtcag cggctgcgga ccgtcgtcca gggcggccag cgcgagctgc ggatcgatca
     9121 cccgctcgcc cttggcgacg gcgcggatgg cgtcgctcag cttctccgga ctgctgtcct
     9181 tcagcagaaa gccggagaca tgggcggcca gcgcccggcg cagattcccg gggcggccga
     9241 ggctggtgag catcatggtg cggcattcgg ggacggcggt gctcaactcg gccgcggcgg
     9301 tgagcccgtc catacccggc agatcgatgt ccagcaccgc gacatccggg cggagctcac
     9361 gggcgcgcgg caggatgtcg gccccgtcgg ggaattcggc caccacctcg atgtccggtt
     9421 cgaattccag cagggcgacc agggccttgc gcaacatatg catgtcttcc gcgatcagca
     9481 ccctgaccat gccgccccct gctccacccg cccggcttcc cccgcatgac gattattccc
     9541 ccgctctccc ggaccttcca tcgattcgcg ggcaaatccg cccgtcgaac gcatatcccg
     9601 tagcacgagc gcgatcgcgc gcccccttgt catgccgcac caccccggca ggcagcggtg
     9661 cgggaaggcg gccaggtccc ggccgggacg ggggccttcg gccggcgggc cgccgcgtca
     9721 tccgggcgcc tggcggttga cccgtacggt ccagcctccg tcggcggcgc ggccggccac
     9781 cgtgatccgt acgtcgtcct ccttgaccga cagggtgtcg ccgacgccga gcggggcgtc
     9841 ggcgagttcg gggtagaccg actcgttcca gcaggcggag gtggtggggt ggccgtccag
     9901 cacctggacg gggccgtcgc cggacgcctt gtcgttgtgg acgcggtaga ccagcacgcc
     9961 ctcggtacag gtgcccgcgt cgttgccgcg gccgccgcgc gcctcgatgg ccagcgcggt
    10021 ggtgggcccg gtacggacca cgaccagccg ggtgcggaag tcggcgccgg gcccgccgcg
    10081 cgccatgggg gcgctgaggg gctggagggt gtatctgcgc ggaccggtga ggcggtcgca
    10141 ggccacctgg cgcgcgccga gccagccgag cttccacttg tgccagccga acggatcggg
    10201 tgccatcccg aactggcttc ccatcaggtc ccagtcgccg acgtaggtgt cccattcggc
    10261 gttaccgtcg gtgtccttcg gccggtggta gaggtcggga aggtcgaaga catgcccggt
    10321 ctcatgggcc agcacattgc ggtccggcgg atggtgctcg aaaacggtga ccagacgacg
    10381 cagatcgaca ccatcggcgc gcagcggctt ttcgaagttg accactttcg tcgcatcggc
    10441 gtccacaccg ggggcatcgg ggtcggcgac cagatagacg aggtcgtagc ggccgaagtc
    10501 gaggtgcgga tcggcggacg cgatggcgtc gcgcagatag gcggcccgcc gctgggcgtt
    10561 ccagtcgcgc tgtatggcgt acgcggtgga ccgctggggc atggcgatcc agcgccgcag
    10621 cggatgtacg cgcagcgcga atttcccgta ggaggccctt ttgaagaagt cgggggtcgc
    10681 ggggatatgg tcggcggcca gccgggcggg ggtcaccctg ggcctggcgt cgggaaagga
    10741 caggaagacc atcgccgcgt ccagtcggcg taccgggcgc ggatagcggg agttccaggt
    10801 gtccaggccc tcggagtggt gggcgtcggt gcgttccagg tcacagggtc cgccggggcc
    10861 ggcggcgacg gcggggcccg ccaccacggt ggtcgcgatg agcgcgctca gcgaggtcag
    10921 cagggcctgg gtccgacgca gccgaggctg ctggtgcact ccctcgggta cctgaggacg
    10981 caccatgtcg acctcccggg cgtagtcgga acacccactc caccctgagg tgaattggcg
    11041 gggtacgccc tgttgagttg ggctggtcga gtgaagaggc cgctatccgg gtacgtaaca
    11101 gacggtcaca ttcggtcaga gcggctgttt gcacgcgcag agtcgaacag atacgaccaa
    11161 acacattgtc aaggcggcgg tgagcgcgat gacgtcgatg gaacgcccga agtacgagcc
    11221 cctatgatcg gcacatcttc agcggggaat cccccttcag gcaggcaatt acggtctgcc
    11281 cggcacccgg tgtgagacat gcgcaagatg tgtacgaaca acttggaaac aacaaacgcc
    11341 acgcgggagc gagcggtgag cggaaccccc gacgggcagg gccgcgcccc gggcgcgacg
    11401 ctgcccgcga tcacagagcg tgatgccatc ccgagcgtcc tccctgtcgc ggaggacccc
    11461 ggcgcaccac gtccggcccc aagcgcgccg tcggtcccgg gcgcgccccc gagcccggtc
    11521 acgcccccgg gcgccgggca cactccgggc ccggcgcccg gcgactaccg cgccgccttc
    11581 aacgcggcgc gcctggccat ggcggtcgtc gaccgcgagg ggagggtgct cgacgccaac
    11641 cccgcgctcg gcgccctgct cggcaccgat ccgggcctgc tgaccacccg cagcgcggcc
    11701 gacctggccg atctgcacga ggatccgcgc acctggcggg agtaccggga ggtcctgggc
    11761 ggccgcctcg cgcggctgcg ccgcacccgg cggctgctgc gcgccgacgg ccatgccctg
    11821 tgggccgaga tcaccgtcga gccggcgccg gacagttgca gtctgctgct gtccatggcc
    11881 gacatcagcg atcagcggga tctccagggg cggctgcgcc atctccagat gcacgacccg
    11941 gtgaccaggc tgcccaaccg cagcctgttc ttcgagcgga tgacctcggc gctggaggcg
    12001 gccacctacg accacgaggg caccggccgg atcgggctct gctacctcga cctggacggc
    12061 ttcaaggcgg tcaacgacac cctcggccac cgggtcggcg accggctgct cggcgcggtc
    12121 gcccagcggc tcatcgactg cgcggcgccc ggcggccatc tggtggcgcg gctcggcggg
    12181 gacgagttcg ccctgctggt ccgcaactcc accggcaccg agcagctgtg cgacctcgcc
    12241 cggtcggtgc tggccgccct tcaggagccg ttcgacgtgg gcgggcagcg gctgtcggtg
    12301 tcggcgagca tcggcgtggt ggagcggccc gcggccggca cccacaccac ctggctgatg
    12361 caggccgcgg acaccacgct gtactgggcc aaggagg
//
