LOCUS       NZ_CP019458            26469 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces autolyticus strain CGMCC0516 chromosome, complete
            genome.
ACCESSION   NZ_CP019458
VERSION     NZ_CP019458.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces autolyticus
  ORGANISM  Streptomyces autolyticus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10029028)
  AUTHORS   Yin,M., Jiang,M., Ren,Z., Dong,Y. and Lu,T.
  TITLE     The complete genome sequence of Streptomyces autolyticus CGMCC 0516,
            the producer of geldanamycin, autolytimycin, reblastatin and
            elaiophylin
  JOURNAL   J Biotechnol 252, 27-31 (2017)
   PUBMED   28472671
REFERENCE   2  (bases 1 to 10029028)
  AUTHORS   Yin,M., Jiang,M. and Lu,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2017) Yunnan University, Yunnan University, 2#
            Cuihu Beilu, Kunming, Yunnan 650091, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Analysis v. 2.3.0
            Genome Coverage                   :: 279x
            Sequencing Technology             :: Illumina; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 03:05:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,227
            CDSs (total)                      :: 8,141
            Genes (coding)                    :: 7,920
            CDSs (with protein)               :: 7,920
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 221
            CDSs (without protein)            :: 221
            Pseudo Genes (ambiguous residues) :: 0 of 221
            Pseudo Genes (frameshifted)       :: 74 of 221
            Pseudo Genes (incomplete)         :: 182 of 221
            Pseudo Genes (internal stop)      :: 9 of 221
            Pseudo Genes (multiple problems)  :: 42 of 221
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:31:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3897012
            Orig. end                         :: 3923481
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP019458.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26469
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="23"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26469
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26469
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16469](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16469)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            204..533
                     /locus_tag="BV401_RS15605"
                     /old_locus_tag="BV401_15550"
     CDS             204..533
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326105.1"
                     /locus_tag="BV401_RS15605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15550"
                     /product="TraR/DksA C4-type zinc finger protein"
                     /protein_id="WP_069866326.1"
                     /transl_table=11
                     /translation="MSLDTAETGPRPGRLTAHEARQRLEHARNSRLAQLQALKETGQST
                     DDHLVSAQTEAIQRVLTEIDEAFARVDDGSYGTCQGCSKPVPAERLEILPYTRHCVACQ
                     RRAAA"
     gene            585..953
                     /locus_tag="BV401_RS15610"
                     /old_locus_tag="BV401_15555"
     CDS             585..953
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972759.1"
                     /locus_tag="BV401_RS15610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15555"
                     /product="TraR/DksA C4-type zinc finger protein"
                     /protein_id="WP_069866122.1"
                     /transl_table=11
                     /translation="MVNHQTMGDRAAHLSPEDLAALRENLHEQRLFRQEQLRRIASAPR
                     AEDLLRRRSAAQAEVHVKLAASARMVLADVEAALQRIAEGSYGACHLCRRPVERERLMI
                     VPQARYCGRCQQVREAGR"
     gene            950..1789
                     /locus_tag="BV401_RS15615"
                     /old_locus_tag="BV401_15560"
     CDS             950..1789
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445461.1"
                     /locus_tag="BV401_RS15615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15560"
                     /product="rod shape-determining protein"
                     /protein_id="WP_069866120.1"
                     /transl_table=11
                     /translation="MTVIRRLRAGSRIRHRHRPWPLCRHCCGLALDMGSARTRAWIAGR
                     GTIIDVPTITFPGAGAVHPIQRGAIVDVPGTARMLDRLLSRRLPRLTRPLVVVTAPVLD
                     GPAYRERARTAVEVLRPRAVLTVPTARAIALAANADLSLPLLVVDIGAHLTEVVLLVDG
                     IVFDARRTALGTTDLADAGATAEISEAITSMITSMLRQDRTSLTADALSRGALLAGGGA
                     LRPDLTRRLIGGLHAPLRAVPAPHTAAVRGAAKILQAAHAHPSAGGTSPPGPGPLSR"
     gene            1926..2564
                     /locus_tag="BV401_RS15620"
                     /old_locus_tag="BV401_15565"
     CDS             1926..2564
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972757.1"
                     /locus_tag="BV401_RS15620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15565"
                     /product="DUF3592 domain-containing protein"
                     /protein_id="WP_079257503.1"
                     /transl_table=11
                     /translation="MSGVIPPAQPPPDPRHDKPVHPLSLWRWRHNPLYRYTDRLQGWIA
                     LALLLLVPVLGLGAMFVAGGAAQHHYRAAAEHRKETLHRTTAVLIHDAPGHPEPGSAEA
                     RETRYPATVRFTDPDGRTRTAKADVLPGLAAGSSVHVWVDKDGAIAEPPMPDAQIRSRT
                     MGWALIAFVTVTLAGAAVYRCTTVVLRRRNLAEWDTEWAETAPRWTTSP"
     gene            2710..3150
                     /locus_tag="BV401_RS15625"
                     /old_locus_tag="BV401_15570"
     CDS             2710..3150
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971994.1"
                     /locus_tag="BV401_RS15625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15570"
                     /product="VOC family protein"
                     /protein_id="WP_079257504.1"
                     /transl_table=11
                     /translation="MTAPRDVPAPEQGLVLTHFLTVRDVARSRRFYADILGGEVVLEEN
                     PAIVKVANSWIIMNPGGGPTPDKPGITLVPPDGGDTVSSFLNVRVADIGAFYAAAVAKG
                     AEFLTEPIDRKAELRCYLRDPDGYLIEVGQATGLLRGVFADR"
     gene            3211..4206
                     /locus_tag="BV401_RS15630"
                     /old_locus_tag="BV401_15575"
     CDS             3211..4206
                     /EC_number="1.13.12.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016703 - oxidoreductase activity, acting
                     on single donors with incorporation of molecular oxygen,
                     incorporation of one atom of oxygen (internal
                     monooxygenases or internal mixed function oxidases)
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606894.1"
                     /locus_tag="BV401_RS15630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15575"
                     /product="nitronate monooxygenase"
                     /protein_id="WP_107429803.1"
                     /transl_table=11
                     /translation="MLHTRFTEMFGITHPVMAAPMGLHSGGTLAAAVSAAGGLGSFAGT
                     HPWKGPDWIHAEIATIRATTDRPFGVGFITPFLPFTEPHFDAALEERPEIIALSFADPR
                     PWLARAKDAGARVVCQVQNYEDAEVAVAAGADVLVAQGNEAGGHTGTMGLLPFLAEIVR
                     RHPDVPVLAAGGIGDGRTLAAVLTAGADGAWLGTAFLATPEAVEVHDAHKRLIVESDGG
                     DTVWTRTYNIVSGLPWPETLGERVRRNRFTDEWSERESTLQNRRAEFAPPEDVNPVEAR
                     PDPDTSEIIYGQSACFVDAVRPAADVVRTISEEAEAILDSRPRSLRTAVR"
     misc_feature    complement(3215..3229)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.67"
                     /tool="antismash"
     gene            4482..5504
                     /locus_tag="BV401_RS15635"
                     /old_locus_tag="BV401_15580"
     CDS             4482..5504
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (80-327). E-value:
                     4.5e-23. Score: 74.1. Matches aSDomain:
                     nrpspksdomains_BV401_RS15635_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060417.1"
                     /locus_tag="BV401_RS15635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15580"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_079257506.1"
                     /sec_met_domain="PF00561 (E-value: 2.2e-16, bitscore: 59.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 9.9e-16, bitscore:
                     57.9, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGTRIGKTNTFAALIAALVTVLVISLGASSGAWGESREHGTATKQ
                     APSPYPKVKPPPGFQSKYANVNGFRMHYLRGGKGSPVVLIHGFPQSWAEWRDQMGPLSK
                     NHTVIAVDLRGAGNSEVTKSGYQKAQMARDVHELLKRLKLNDGVQVVGHDVGLWVSYAY
                     AAQWPSEVRRMAVMEAPIPDDSLYRFPALEANPKTPSMWHFGLFQLPLAEQLISGHERV
                     FVRGFIGELLVNKSAFTPADYDFYAHYLKQPGRTLAWMRMYRQLREDVQQNKKFLAEGK
                     LRMPILAIGGQASFGGKIADQWRDYAMNVHGRVVKGSGHWVTEEKPREVTAMLQSFLRK
                     "
     aSDomain        4722..5462
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BV401_RS15635_Abhydrolase_1.1"
                     /evalue="4.50E-23"
                     /label="BV401_RS15635_Abhydrolase_1.1"
                     /locus_tag="BV401_RS15635"
                     /protein_end="327"
                     /protein_start="80"
                     /score="74.1"
                     /tool="antismash"
                     /translation="PVVLIHGFPQSWAEWRDQMGPLSKNHTVIAVDLRGAGNSEVTKSG
                     YQKAQMARDVHELLKRLKLNDGVQVVGHDVGLWVSYAYAAQWPSEVRRMAVMEAPIPDD
                     SLYRFPALEANPKTPSMWHFGLFQLPLAEQLISGHERVFVRGFIGELLVNKSAFTPADY
                     DFYAHYLKQPGRTLAWMRMYRQLREDVQQNKKFLAEGKLRMPILAIGGQASFGGKIADQ
                     WRDYAMNVHGRVVKGSGHWVTEEKP"
     gene            5877..6794
                     /locus_tag="BV401_RS15640"
                     /old_locus_tag="BV401_15585"
     CDS             5877..6794
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BV401_RS15640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BV401_15585"
                     /product="hypothetical protein"
                     /protein_id="WP_079257507.1"
                     /transl_table=11
                     /translation="MGVGAATTDELKLGEVVTRRELHARFGGTPQGGISPSTRSQMVMA
                     FVTERPNPDDFTGWGDDGVFHFAGAGMHGDQEMTRGNLALLRHKEQERAVHLFHQLRRH
                     SDKPGRLYRHLGRFEVDPEQPYYVADAPDANGFMRTVIVFRLRPVGATVPDGPRLPVTP
                     PTETRITRALDFRLTSVRRQPQETAGDIVKRLTAEYASHLNGLGREVVSAQVRVKGETS
                     VTRVDLLDVTGNRLIEVKHSAARQAVRTAIGALMDYRRFFDPTPTLALLVPAAPRADLL
                     DLCASLCIEVVWPNPEGGFTSTHD"
     misc_feature    5925..5938
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.0"
                     /tool="antismash"
     gene            6917..7093
                     /locus_tag="BV401_RS43510"
     CDS             6917..7093
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126911.1"
                     /locus_tag="BV401_RS43510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_167746831.1"
                     /transl_table=11
                     /translation="MCENNAVPEVRNGHDATTARIYGLALVAGVLLIIFKNTSPVEASG
                     FVSPFLVMFEQRR"
     gene            complement(7246..7413)
                     /locus_tag="BV401_RS43125"
     CDS             complement(7246..7413)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BV401_RS43125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_158525901.1"
                     /transl_table=11
                     /translation="MVTDLGALLNKRLLPALTKKLRHVTTAQPKITSVQPLAADTEQLD
                     TTPHTEGTRK"
     gene            7599..8105
                     /locus_tag="BV401_RS15645"
                     /old_locus_tag="BV401_15590"
     CDS             7599..8105
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BV401_RS15645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BV401_15590"
                     /product="hypothetical protein"
                     /protein_id="WP_148666264.1"
                     /transl_table=11
                     /translation="MAFRVLIGGGAVGSVGVLFSPRRVEVGEQRAEDVGLGALPRVVVA
                     GAVEQAGVDGGASNGVDGAELLLVGVRVPGPVLEAYRAVDQVGALDPAAEVDLLEELWE
                     LFRLEVERPVRQARDVAEEGEPGDGAEGDVDAAAAEGLVSGVEDVLCDLAGVLVRVARR
                     RSAGP"
     gene            complement(8204..8347)
                     /locus_tag="BV401_RS43130"
     CDS             complement(8204..8347)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BV401_RS43130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_158525902.1"
                     /transl_table=11
                     /translation="MRWAGWGVITESMPAGLWAACHPDYRDKPFPHLPARLARPNGGPD
                     GH"
     gene            complement(8452..8844)
                     /locus_tag="BV401_RS15650"
                     /old_locus_tag="BV401_15595"
     CDS             complement(8452..8844)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BV401_RS15650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BV401_15595"
                     /product="hypothetical protein"
                     /protein_id="WP_079257509.1"
                     /transl_table=11
                     /translation="MDDSNETTHRVRITARGPKAKIEIDGQQIDPGALTSYTLSHHTGE
                     PPHLILDSEHLDSLAFDGLARVAIADVPAPGPAAAIFLDAIDAEELERAALARPDLGTE
                     PYSLTKAMLTQLGEWARSARLPGLPG"
     gene            complement(8881..9921)
                     /locus_tag="BV401_RS15655"
                     /old_locus_tag="BV401_15600"
     CDS             complement(8881..9921)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325336.1"
                     /locus_tag="BV401_RS15655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15600"
                     /product="hypothetical protein"
                     /protein_id="WP_237287631.1"
                     /transl_table=11
                     /translation="MREISDLARSAEHEGKLSLAAAAQNKAALIASDCGMPDLARTLCW
                     RHAEVYLCAQSLSAQEARYALEPVVNIARLLIRDGDANGAYRLLDALVQAARTRGRAEV
                     DGHTICFKYLTTTDEEHQQLHQWLWTILLGDGTRALVAAGAWNRARSQARRHRGVGHRL
                     LDGRQVEVLGRCLAGDPDGAYAFLGESVPTEPWEHSVASCLAALCRHLSGINDETIMTA
                     MVRNYLNLDTTAELDLFRTRLGLTALDLTEPDPALATAVTTRLLPEAASCRNGYVAREV
                     LAHPSCRERLNPPAERILYAAVYSAGLDQGHMPTPLERELLQAAESGATTTEHLLAHKR
                     PATGST"
     misc_feature    complement(8956..8958)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10001..12085)
                     /gene="fxlM"
                     /locus_tag="BV401_RS15660"
                     /old_locus_tag="BV401_15605"
     CDS             complement(10001..12085)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325335.1"
                     /locus_tag="BV401_RS15660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15605"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_079257511.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.1e-32, bitscore:
                     112.7, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 1.5e-45, bitscore: 154.4,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDDEWPQRVIEFTDWPDAERVAVAHLRPILDSGGTRQWSFIRKA
                     PTWRLRYRPDPADPTYLDQALDTLVADGAVREWVPGIYEPETAAFGGPDGMELAHEFFH
                     RDSRHVLDQLACQQQNPGSPVLGRRELAIVLFSACLRAAGLDWYEQGDVWARVEAERQH
                     PDRALLQRHRAAVRRLMTVDVGPHSSPVADGRLAYITDWVTTFEWAGQQLAHLNRRGRL
                     ERGLRAVLAHHLIFHWNRLGLPREDQSALSTLAKEVVMGTNDTAASTPSTGEAATTVTG
                     VNSDTIETSPDDLRAHLVDQLVQDSSIRTARVEQAMRAVPRHLFVPQAPLEKAYSNTTV
                     DTKYDSAGRSISCASQPGIVALMLEQLHVEPGMKVLELGAGTGFNAGLLGHLVGEQGHV
                     TTIDVDHDIVEGARIGLKAAGLGNVTVILGDGAQGYAANAPYDRIVATVGAHAVPLAWL
                     DQLAPGGRLLSPLRLRGSVSRSIAFERDAERRWRSVGSEMNTFMPLRRGIADDPRIFVP
                     LTEDGSVTLVTNGDQTVDTDALADVLNQPRAEAWTGVTFRGPESPEWLELWLTCALPNG
                     LSRMPAKREAIDSGLLTNPYASSTATFDKGTLTYLTRRKADHTAEDGAPLYEFGVIGHG
                     PDADHLTERVTEAVRTWDSDFRTRNVAFEIRPLDAPSPEQKPGRFTFDNPLNRIVIEWQ
                     "
     misc_feature    complement(11579..11581)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(12106..13380)
                     /locus_tag="BV401_RS15665"
                     /old_locus_tag="BV401_15610"
     CDS             complement(12106..13380)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491155.1"
                     /locus_tag="BV401_RS15665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15610"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_079257512.1"
                     /sec_met_domain="LANC_like (E-value: 3.9e-46, bitscore:
                     156.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITPQNDYDVQTAVDLIADRLASPEQARTWNLTHGWWPQSLANGA
                     VGVALLHIERARIGLASWQRAHDWLACAAAGGAVGGPDSHPFYGVPALTFALHAAATGW
                     PDRYSRALETLDKHLAATVQARLAAAHARIDRGEPPALAEFDAIRGLSGMAALLMCREV
                     HTDLARQVIAYLVRLTEPIEDGEELLPGWWSALAPSGAPSTDFPRGHGNNGMAHGIAGP
                     LAALSLATFHGITAPGQSKAIERICSWLDRWQQQGLAGPWWPYWITREQLGTGDPGIGP
                     SRPSWCYGAAGIARAQQLAALALGDTARQHMAEDTLLRAVTDPGQLDQTTDASLCHGFA
                     GLIHLTQLAAADAINPGLAQALPHLLQRLVPAGPQVLADSLLAPPQGAAAIGLLEGAAG
                     IAMALHSTQEGTSAATVWNACLLIN"
     gene            complement(13377..16469)
                     /locus_tag="BV401_RS15670"
                     /old_locus_tag="BV401_15615"
     CDS             complement(13377..16469)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325333.1"
                     /locus_tag="BV401_RS15670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15615"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_079257513.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.3e-199,
                     bitscore: 663.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.2e-16,
                     bitscore: 60.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.5e-21, bitscore:
                     76.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATKSCLPYRCAGTAMVRASGHRLPLASWPDLADSSPHRVARWRG
                     WLQAAWDREELAAAVEQASPALARQVHAVCVGEVEDARRVRRAASALVRYALRMHGRAT
                     PFGLFAGVVPVAFADEPLVVWGDQHRAFVRADGTWLADVIKRLEACPAVLHRLSLVANN
                     CAFLRGGRLVVPYPPRSGRAEEPAAEVSLRYTAAVRLVVEAARAPLRGRELVEKVSAEF
                     HQVALSKVESLVTSLVSQGVLLSALHAPAGTFDAFDHLMQQMAGAGVEDVPDVAQLTAR
                     LQKVQSKLAAHNAPTGPVEGRRLRAALRTDMLAVSTVVEQPVAVDARLDCTLVLPHQVA
                     RAAEEAVSLLARLSPFPYGSPAWKSYHNRFFERYGIGSLVPVRDLVDADLGLGFPDGYL
                     DAEPEAGTAVSGRDRHLFALAQQAALEGRDEVHLDEELVRALTPGEPDRVRLPPHLELR
                     FRLQAPDIAAVARGEFTLAVVSPSRGIGTTTGRFIGLLDPEEQAQARKAFIHLPTSDSG
                     ARPVQLSFTPLNRCDTHVTRAPDVLPDVISLAEHRVEGSAGLIALDDLAVGCDPQRLFL
                     ASLSRQQRLEPMAPHALDLRAHTPPLARFLLEIAKATSTVVTPFTWGAANALPFLPRVR
                     YGRTILSPARWRLHRSDVPDRRAAWPQWREALEQWRQRSRVPDWVALTEGDRALPLNLT
                     EAAHLELVRSHLATSESAVLTETQPGADGWLDGHAHEITVPLQADHPALSRATPPVSTA
                     RLVTREHGHVPGASRWLMAKIYSHAKRHPEILGHHLPGLFARWEQPPMWWYTRYRDPRW
                     HLRLRLALADVGDFGTGAARIAEWATELRRQGLVGDVQFATSYPETGRWGTAGGLEAAE
                     TVFAADSAVLVTAFAQPARPHPQALAAANLVATATAFTGSTVVGMDWLIRHGHLTDPGP
                     LDRAVRAEALSLADPTGDWAGLRAAPGGTAIHATWAARARVLTAYGDRLRACDDGTDPD
                     AVLDSLLHAHHIRAAGIDKADERTCIRLARAAALAWKARSA"
     misc_feature    complement(14985..14987)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        complement(15720..15995)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BV401_RS15670_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="4.10E-19"
                     /identifier="RREFam001.1"
                     /label="BV401_RS15670"
                     /locus_tag="BV401_RS15670"
                     /protein_end="250"
                     /protein_start="158"
                     /score="60.1"
                     /tool="antismash"
                     /translation="LVANNCAFLRGGRLVVPYPPRSGRAEEPAAEVSLRYTAAVRLVVE
                     AARAPLRGRELVEKVSAEFHQVALSKVESLVTSLVSQGVLLSALHAP"
     misc_feature    complement(15999..16001)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16562..16690)
                     /locus_tag="BV401_RS15675"
                     /old_locus_tag="BV401_15620"
     CDS             complement(16562..16690)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491158.1"
                     /locus_tag="BV401_RS15675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15620"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_232564462.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 3e-17, bitscore:
                     61.1, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEDEFELDITVLESGDRSAKLINLTDDGCGSTCSSPCASSVA"
     misc_feature    16674..16689
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.61"
                     /tool="antismash"
     misc_feature    16941..16959
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.09"
                     /tool="antismash"
     gene            complement(17034..17864)
                     /locus_tag="BV401_RS15680"
                     /old_locus_tag="BV401_15625"
     CDS             complement(17034..17864)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF020897.4"
                     /locus_tag="BV401_RS15680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15625"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_158525903.1"
                     /transl_table=11
                     /translation="MLRALEWLACQGEMMAITDPDMVQSQVGVLNKVSAILAVLEEGPA
                     HLETVISETGLKRPTVRRLVLAMQELGLVESDQQEQFIVGPRLIRLARAVHQAIVHREL
                     RQQLGALRATTGVRSVRLERRCDDQRICMAEDPRLNSAATDRKPARVAAMGDDPVSRVF
                     LAWQELSQGREVWRDAAAECSAIRCRGWVEGVADGGLVLAVAVRGRDGELAAVLSLSSH
                     FQRTRREASYGHEVITVAIEAAARISHHLRANETTGLVEGLEDRAQRVGPRSVE"
     gene            complement(17906..18187)
                     /locus_tag="BV401_RS42780"
                     /old_locus_tag="BV401_15630"
     CDS             complement(17906..18187)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039648.3"
                     /locus_tag="BV401_RS42780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15630"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_148666265.1"
                     /transl_table=11
                     /translation="MKYEPTALGNVAMTAKLEDLPRIPRGKRLIGKDRERFRESIKAVY
                     ENNLDVTIRDIREVTGRSFGSIRAMLVESGVELRPRGGSYSRDEALEI"
     gene            complement(18844..19065)
                     /locus_tag="BV401_RS15685"
     CDS             complement(18844..19065)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BV401_RS15685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_079257516.1"
                     /transl_table=11
                     /translation="MAVLVEHAAAWGVAGVVHAPETLRPVPGEHGEPFTLVAYDDPRLP
                     WTLACREVVALHGCTAVDLGDLTEHTAA"
     misc_feature    complement(20717..20732)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.73"
                     /tool="antismash"
     misc_feature    complement(20794..20809)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.24"
                     /tool="antismash"
     gene            20853..22010
                     /locus_tag="BV401_RS15690"
                     /old_locus_tag="BV401_15645"
     CDS             20853..22010
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013540.4"
                     /locus_tag="BV401_RS15690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15645"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_148666266.1"
                     /transl_table=11
                     /translation="MAPQKRSRSETGTLTAGQGPPTRTASGIVCGHLLKIIRERIPLTQ
                     SRLAEELGIDTTTVQGWESGRRSLAAISSAQFLRLKRHLLGRGAEPTLLPLLDLAVEAD
                     SVIEYSLNDTLNSDDITQHPLHSWVFTRASTHMIAWALTGEQPTILPKAPASTPRRRGP
                     TPGSPLLPTPQRDKLFANLRRTAEIADRAGEDGSLLRRQALYLCAYDTSVDTHSWLADM
                     RERRQPPLRHASWTPAWSDARSVATSLTRYGDSETLQTFIERGMGGDASEMANLNYWAH
                     WLGLDPVPRASDAFMSDVDGRSWEALPLLRNLADRLDPSLGAVDLNIHSVWALISSKPG
                     VLSADRELHRDLTSRVDRLLDSDVISRQSRRELENVHYGLRLSSR"
     gene            22034..22609
                     /locus_tag="BV401_RS15695"
                     /old_locus_tag="BV401_15650"
     CDS             22034..22609
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014137148.1"
                     /locus_tag="BV401_RS15695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15650"
                     /product="HD domain-containing protein"
                     /protein_id="WP_079260442.1"
                     /transl_table=11
                     /translation="MTDDQADKGTVGYLFEMGALKRGKRSGWWIAGVKDPETIAEHSFR
                     TAIIGAVLAMMEGADPAKVALLCTFHDTQETRVGDIPWIGRRYLEAASNERVTADQVSK
                     TPPAVAEGIKAVVHEYENGDSLEVLVAHDADKLECMLQGMEYLEQGYRNAQEWVDTTRA
                     KLKTPSALALAEAAQGMSSMEWKHTYLG"
     gene            complement(22720..23049)
                     /locus_tag="BV401_RS15700"
                     /old_locus_tag="BV401_15655"
     CDS             complement(22720..23049)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019063615.1"
                     /locus_tag="BV401_RS15700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15655"
                     /product="hypothetical protein"
                     /protein_id="WP_079257518.1"
                     /transl_table=11
                     /translation="MDEFQRSWLLAQLGPDTDSADLERRFFRLRSARAVALEVLGERRA
                     KLLGDPLKVTVDGVVTMDLQENLRGIERQIDAICQTSAPDDPEDGDGEGNTLATSFMVP
                     SRRYR"
     gene            complement(23403..24314)
                     /locus_tag="BV401_RS15705"
                     /old_locus_tag="BV401_15660"
     CDS             complement(23403..24314)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015802.4"
                     /locus_tag="BV401_RS15705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15660"
                     /product="major capsid protein"
                     /protein_id="WP_237287632.1"
                     /transl_table=11
                     /translation="MKDSGRYVNVAKYRAFNASVPFATREAWQTSREGALPALGQKLMV
                     SEQEQILLEASHGSDQDRLIELLYDDVERHVEAIQSRLEMAAGDVLADGKFSLVQENGL
                     TLEVDWNVPAANMPVAQRPWWDPASDPIADELRWIQHLDDVGAPEPELVVTSRKAFSYL
                     AANNAYRAAYYGSVNPSTTPTATLTPQQINVVRGNYSLPPITFYKAQVRVDGKPRKVLP
                     EDLWCLIPPDREKWAQTQIGVTAEALVLSRGTNPEIIREDAPGIIITRGVQDDPVQIYT
                     KGAAVGMPVMHTPDAHIVAKVL"
     misc_feature    complement(24464..24479)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.15"
                     /tool="antismash"
     gene            24622..24909
                     /locus_tag="BV401_RS15710"
                     /old_locus_tag="BV401_15665"
     CDS             24622..24909
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669318.1"
                     /locus_tag="BV401_RS15710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15665"
                     /product="hypothetical protein"
                     /protein_id="WP_079257519.1"
                     /transl_table=11
                     /translation="MSSDAPWTIERIRDALGDPDLAQRFLSEINRAPVHELLSTFARWE
                     HIAKNTLATVQRARELATHDARDEEPLGEWVDATERIQREAEQIRGYGAA"
     repeat_region   25323..26143
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=3922639..3922667
                     /rpt_unit_seq="cggaacacccccacgtcggcggggaggac"
ORIGIN
        1 cgtgtggtca ccactgccca gggcaaatgg ggtctgcgcc cgatgggctt ccggcgccgg
       61 gtcgagcaga gtcgtaggtg accgagccgc ccggttcggc cgattcgtgg tcggggagac
      121 cgcggccggc ggaaccgggc ggccactgct gcgcccggtg cgcttcgatg cccgccgggc
      181 gcgctgagag aaaggacctc atcgtgtcgc tcgacaccgc cgagaccggt ccccgccccg
      241 ggcggctgac cgcccacgag gcccgccagc gcctcgagca cgcccgcaac agccgcctgg
      301 cccagctgca agccctcaag gaaaccggcc agagcacgga cgaccatctg gtgtccgcgc
      361 agacggaggc gatccagcgg gtcctcaccg agatcgacga ggcgttcgcc cgcgtcgacg
      421 acggctccta cggcacctgc cagggctgct ccaagcccgt ccccgccgaa cgcctggaga
      481 tcctccccta cacccggcac tgcgtggcct gccagcgccg cgccgccgcc tgaccggcgc
      541 cccgtcccac ccgtcttcgt ctccgccctg ctcaaagggg tgaagtggtg aatcaccaga
      601 ccatgggcga ccgtgccgcg cacctgtcgc ccgaggatct cgccgcactg cgggagaacc
      661 tccatgaaca gcgcctgttc cgccaggaac agctgcggcg gatcgcctcg gcgccccgcg
      721 ccgaggacct gctccggcgc cgctccgcgg cccaggccga agtgcacgtc aaactcgccg
      781 cctccgcgcg tatggtcctc gccgatgtgg aggcggcgct gcaacgcatc gccgaaggca
      841 gctacggcgc ctgccatctg tgccggcgcc ccgtcgaacg ggaacgcctg atgatcgttc
      901 cgcaggcccg ctactgcgga cggtgccagc aggtgcggga ggccgggcga tgaccgtcat
      961 ccggcgcctc cgggccggct cccgcatcag gcaccggcac cggccctggc cgttgtgccg
     1021 gcactgctgc ggcctcgccc tcgacatggg cagcgcccgc acccgcgcct ggatcgccgg
     1081 ccgcggaacg atcatcgacg tacccaccat caccttcccc ggtgccgggg cggtccatcc
     1141 gatccagcgc ggtgccatcg tggacgtacc ggggacggcc cggatgctcg accggctgct
     1201 cagccgccgg ctgccccgcc tcacccggcc gctggtggtg gtcaccgcgc cggtgctgga
     1261 cggccccgcc taccgggaac gtgcccgcac cgccgtggag gtgctgcgcc cgcgcgcggt
     1321 cctgaccgtg cccaccgcgc gggccatcgc cctggccgcc aacgccgacc tctcgctgcc
     1381 gctgctggtg gtggacatag gcgcccacct caccgaagtg gtgctcctcg tcgacggcat
     1441 cgtcttcgac gcccgccgca ccgccctggg caccaccgac ctcgccgacg ccggtgccac
     1501 agcggagatc agcgaggcca tcaccagcat gatcacctcg atgctgcggc aggaccgtac
     1561 gtctctcacc gccgatgccc tgagccgggg agcccttctg gccggcggtg gcgccctgcg
     1621 ccccgacctc acccgccggc tcatcggcgg actgcacgcg ccgctgcggg cggtcccggc
     1681 accgcatacc gccgcggtcc gtggcgccgc caagatcctg caagccgcgc acgcccatcc
     1741 ctcggcgggc ggcacgtccc cgcccggacc cggcccgctc tcccgctgag cccggtcccc
     1801 ctcggctttt cccgcaccgc accggccgcg cgccggtcgc ggtcgcacgc ccacttccgc
     1861 ccagcttctg tccagcttcc gtccaggaaa tctgtccggc ttccgtccag gaaaggagac
     1921 ccacagtgtc cggcgtgata cctcctgcgc agccgccccc cgacccccga cacgacaagc
     1981 ccgtccaccc cctgtcgctg tggcgctggc ggcacaatcc gctgtaccgg tacaccgacc
     2041 gtctccaggg ctggatcgcc ctggcgctgc tgctgctcgt gccggtcctg ggactcggtg
     2101 ccatgttcgt cgccggtggc gccgcccagc accactaccg cgcggccgcc gagcaccgga
     2161 aggagaccct gcaccgcacc accgccgtcc tcatccatga cgccccgggc cacccggagc
     2221 ccggatcggc ggaggcgaga gagacccgct acccggccac ggtccgcttc accgatccgg
     2281 acgggcggac ccgcaccgcc aaggccgatg tcctgcccgg cctggccgcg gggagctccg
     2341 tccacgtctg ggtcgacaag gacggggcga tcgccgaacc gcccatgccc gatgcgcaga
     2401 tccgcagccg caccatgggc tgggcgctca tcgccttcgt gaccgtcacc ctcgccggtg
     2461 ccgccgtcta ccgctgcacc accgtggtcc tgcgccggcg caatctcgcc gagtgggaca
     2521 ccgagtgggc cgagaccgca ccacgctgga ccacctcccc ctgagccccg gcttcgcact
     2581 cgggacagcg gccggccgcg cccccgcgca tatcgcgctc ccaccgggtt acccaaggag
     2641 gacgagccgg gcatgagaag cgcgcatgcg ctcggcccgg ctctccaccg gcgagaaggg
     2701 accacggcga tgacggctcc ccgcgatgtg cccgcacctg agcaggggct cgttctcacc
     2761 cactttctga ccgtgcgcga cgtcgcgcga tcgaggcgct tctacgcgga catcctcggc
     2821 ggcgaggtcg tactggagga gaatccggcc atcgtgaagg tggccaacag ctggatcatc
     2881 atgaaccccg gaggcggccc caccccggac aagcccggca taaccctcgt accgccggac
     2941 ggcggtgaca ccgtgtccag ttttctgaac gtccgcgtcg ccgacatcgg cgccttctac
     3001 gccgccgccg tggccaaagg agcggagttc ctcaccgagc ccatcgaccg caaggccgag
     3061 ctgcgctgct atctgcgtga ccccgacggc tacctcatcg aggtgggtca ggccaccggt
     3121 ctgctccggg gggtgttcgc cgaccgttag ccggccgggg ccgccgcgtc gctcgcgggc
     3181 cgggcccgcc gcgttcgtta gcgtcgcccc gtgctgcata cgagattcac cgaaatgttc
     3241 ggtatcaccc acccggtgat ggcggccccc atgggcctgc acagcggcgg aacgctcgcc
     3301 gccgccgtat ccgccgccgg tgggctcggc tccttcgcgg ggacgcaccc ctggaagggg
     3361 cccgactgga tccatgcgga gatcgcgacc atccgcgcca cgacggaccg cccgttcgga
     3421 gtcggcttca tcacgccgtt cctccccttc accgaaccgc atttcgacgc cgcgctggag
     3481 gagcggccgg agatcatcgc gctgtcgttc gccgaccccc ggccgtggct cgcccgcgcc
     3541 aaggacgcgg gggcccgggt ggtgtgccag gtccagaact acgaggacgc ggaggtggcc
     3601 gtcgccgcgg gcgccgatgt gctcgtggca cagggcaacg aggccggtgg ccacaccggg
     3661 acgatgggcc tgctgccgtt cctggccgaa atcgtacggc gtcaccccga tgtcccggtg
     3721 ctggccgcgg ggggcatcgg cgacggccgg acgctcgcgg cggtcctcac cgcaggtgcg
     3781 gacggcgcct ggctgggcac ggcattcctc gccacccccg aggcggtcga ggtgcacgac
     3841 gcccataagc ggctgatcgt cgagagcgac ggcggcgaca ccgtatggac gcggacctac
     3901 aacatcgtgt cggggctgcc ctggccggaa accctcggcg aacgcgtccg ccgcaatcgg
     3961 ttcaccgacg agtggtcgga gcgtgagtcc acactccaga accgcagagc ggaattcgca
     4021 cccccggaag acgtcaaccc cgtcgaggcc cggcccgacc ccgacacgag cgagatcatc
     4081 tacggtcagt cggcatgctt cgtcgacgcc gtccgccccg ccgcggacgt ggtccggacg
     4141 atcagcgaag aggccgaggc gatcctggac tcacggcctc gatcgctacg cacagcagtc
     4201 agatgacccc tgagccgttg gagccgcccg cgccctgccg ggcccctgat cttcgtccga
     4261 acgaatgaac ggaagccatc gccgaggagc gctgccggtc cgcatccgcg ggcagcctcc
     4321 ccgaacgtca cctccaatgg cgtatccccg cgcgctgtgc acaccatggt ccggtagggc
     4381 cacagtgggt gcaggcattt cttcgccctg ccccgcattc accatttccg ctggaagcat
     4441 tcatgacgca cggcaggtga atcacttcag gtaggtgaat catgggcacc cgaataggaa
     4501 agaccaacac attcgccgca ctcatcgcgg cactggtgac cgtcctggtg atctccctcg
     4561 gcgcgagttc cggagcatgg ggcgagagtc gcgagcatgg caccgcgacg aaacaagcgc
     4621 cgtcgcccta cccgaaagtg aaaccgcccc ccggctttca gtccaagtac gcgaacgtga
     4681 acggcttccg catgcactac ctgcgaggcg gcaaaggttc accggtcgtg ctgatccacg
     4741 ggtttcctca gtcgtgggcc gagtggcggg accagatggg accgctctcc aagaaccaca
     4801 ccgtgatcgc cgtcgacctc cgcggcgccg gcaactccga agtcaccaag agcggttacc
     4861 agaaggcgca gatggccagg gacgtgcatg aactgctgaa gcggctgaag ctgaacgacg
     4921 gcgttcaggt cgtcgggcac gacgtcggcc tgtgggtcag ctacgcctac gcggcccagt
     4981 ggccgtccga ggtgcgccgc atggccgtga tggaagctcc catcccggac gacagcctgt
     5041 accgcttccc ggctctggag gccaacccga agaccccgtc gatgtggcac ttcggcctgt
     5101 tccagttgcc gctcgccgag caactcatct ccggtcacga gcgcgtcttt gtccgtggct
     5161 tcatcggaga gcttctcgtc aataagtccg cgttcacgcc ggccgactac gacttctacg
     5221 cccactacct gaaacagccg ggccgcacgc tggcctggat gcgcatgtac cgccagctcc
     5281 gcgaagacgt ccagcagaac aagaagttcc tggccgaggg caaactgagg atgcccatcc
     5341 tggcgatcgg cggccaggcg tcattcggtg gcaaaatcgc cgaccaatgg cgtgactacg
     5401 ccatgaacgt ccacggccgg gtcgtgaagg gttcgggtca ctgggtgacc gaggagaagc
     5461 cgcgagaagt gacggccatg ctccagtcct tcctccggaa gtaggctcca ccacacgcgc
     5521 cgacccccga aggggcgccg gaaggcggct gaaggctccc tgccccctga accagcctcg
     5581 tgtcccctgg atggcccctg gatcttcgtc tgaacggatg aacgggaacc cccgcatcgg
     5641 cgcggcagtc gtacgcggcc agcagacgat aggcggtgag gcgccacagg cgccacccta
     5701 cgcgcctggc actccacctc agaccgtcaa taacgaatca ataacgctca acagggagat
     5761 ccgttacctt tcatccgcat ttctgggctt aagcacaggt caagcaaccc ccgcctgcca
     5821 catgacatcg agaagtcacc ctctctcatc acggtgactc aggtagtctt catggcatgg
     5881 gagttggggc ggcgaccacg gacgagctga agttgggcga ggtagtgacg cggcgtgaac
     5941 tgcacgcgcg cttcggcggt accccccaag gcggcatctc accatcgacg cggtctcaga
     6001 tggtgatggc cttcgtcacc gagcgaccta acccggacga cttcactggg tggggggacg
     6061 acggagtttt ccactttgca ggcgctggca tgcacggcga ccaggagatg acgcgaggaa
     6121 acctcgcgct gctgcgccac aaggagcagg agcgcgcggt gcacttgttc caccagctcc
     6181 ggaggcactc agacaaacca ggtcggctct accgccatct ggggcgcttc gaggtcgacc
     6241 ctgagcagcc gtactacgtc gcggacgccc cagatgccaa cggcttcatg cggaccgtaa
     6301 tcgtcttccg gctgcggccg gtcggagcca ctgtccccga cggaccgcgc ctgccggtca
     6361 ctccgccgac cgaaacacgc atcaccaggg cgctggactt caggctgacc agtgtgcgcc
     6421 gacagcccca ggaaactgcg ggagacattg tcaaacgctt gactgcggag tacgccagcc
     6481 acctgaacgg tcttgggcgc gaggtcgtca gcgcccaggt acgcgtgaag ggcgaaacct
     6541 cggttactcg tgtcgatctt ctggacgtca ctgggaacag gctgatcgag gtgaaacaca
     6601 gcgccgcccg gcaagcagtt cggacggcga tcggcgccct catggattac cgccgcttct
     6661 tcgacccgac tcccaccctc gcgctactcg tgcccgcggc gccgagggcg gacctgctcg
     6721 acctctgcgc atccctgtgc atcgaggtcg tatggccgaa ccctgaagga ggtttcacgt
     6781 cgacccatga ctaacggctg aggcgtatgc gcactgcaat gcgccgccgc cccagccgcc
     6841 gtctggttac cacaggggtc ctagtcgctg tgagtaaccg tgcccttgtc cagcaaagaa
     6901 caggagctac tccattatgt gcgaaaacaa cgccgtgccc gaagtcagga acggtcacga
     6961 cgccaccacg gcccgaatct acgggctcgc cctggtggct ggcgtgctgc tgatcatctt
     7021 caagaacacc agcccggtcg aagcgtcggg attcgtctcc ccgttcctgg tcatgttcga
     7081 gcagcggcgg tagctagccg gtggcggtcg ctccagtggt gcgaccgcca ccgtgcccga
     7141 ggcagatcac tccgtcggtt cacaccgcgg atcacagctt cttcccgccc gcctcagcca
     7201 tggcctcgtc gtagccgggc acctgcatgg tgtcgtcggg cgtgctcact tccgggttcc
     7261 ttccgtgtgc ggtgtggtgt cgagctgttc ggtgtcggca gccagcggct gcacgctggt
     7321 gatcttcggc tgtgcggttg tcacgtggcg tagcttcttc gtgagggctg ggagcagccg
     7381 tttgttgagc agtgcgccga ggtcggtgac caaggcgtcg cttgtgcggg tggcgaggac
     7441 ggcgtgccag gtgcggccgg ctggagccgg gcgtcgttgg cggcttgtgc ctcggcccgc
     7501 tcggtgtcgg tgccgtcagg gatcggcggc aggtcggggc gagcggtgat ccaggtctgg
     7561 atggcgaggc cgcgagactg gacgcggagg cccacgcggt ggccttcagg gtgctgatag
     7621 gcggcggtgc ggtcgggagt gttggtgtcc tcttttctcc acggcgggtc gaggtcgggg
     7681 agcagcgggc tgaggacgtc ggcctcggag cgttgccaag ggtcgtcgtc gccggtgcgg
     7741 tcgagcaggc cggtgttgat ggcggcgcga gtaacggcgt ggacggcgcg gagctgctgc
     7801 ttgtcggggt cagggttcca ggcccagtcc tggaggcgta tcgcgcggtt gatcaggtcg
     7861 gggcgcttga tccagcggcc gaggtagatc tccttgagga gctgtgggag ctcttccggc
     7921 tggaggttga gcgcccagtc cgccaggccc gggatgttgc ggaggaggga gagcccggcg
     7981 acggtgccga gggggacgtc gatgctgctg ccgccgaagg actggtatca ggcgtcgagg
     8041 acgttctctg cgatcttgcg ggcgtgctcg tgcgggtcgc gcggcggcgt agcgccgggc
     8101 cgtgatcttg ccggtgggac gggccttggg cttgggcggg ggcttcttca cccaagaggg
     8161 cgcgggccgc gcgacgaccg gggctgccgc gcgaggcaag aagtcagtgg ccgtccggcc
     8221 cgccattggg gcgggccaga cgggcaggta ggtgggggaa gggcttgtcc cggtagtcgg
     8281 ggtggcaggc ggcccacaga cccgcgggca tggattcggt gatgacgccc catccggccc
     8341 agcgcataac ggcgagatag ccgaggtctc cgcccgcgaa tccggtccgt ggcgtcgggg
     8401 tcggggccgg ggccggggga gatgaacacg aagccgggca ggtcgccggt gtcatccggg
     8461 aagacctgga agccgggccg aacgggccca ctccccgagc tgggtgagca tggccttcgt
     8521 cagcgagtac ggctcggtgc cgaggtcggg gcgggccagc gcggcacgct ccagttcctc
     8581 ggcgtcgatc gcgtccagga agatcgcagc ggctgggccc ggggcaggca cgtcagcgat
     8641 cgcgacgcgg gccaagccgt cgaacgcgag actgtcgagg tgctcggagt cgaggatgag
     8701 gtgcggtggc tcgcccgtgt ggtggctgag cgtgtagctg gtcagggctc ccgggtcgat
     8761 ctgctgtccg tcgatctcga tcttggcctt cggccccctc gcggtgatgc gtacccggtg
     8821 cgtggtctcg ttgctgtcat ccatgcaggc gacgctaagt gggctgtcgg acaagcctga
     8881 tcaggtgctg cccgttgcgg gccgcttgtg agcgagaagg tgttccgtcg tcgtggcccc
     8941 ggattctgct gcctgtaaga gctctctttc caggggcgtg ggcatgtgtc cctggtcgag
     9001 tcctgccgag tagacggccg cgtacaggat tctctccgcg gggggattga ggcgttctcg
     9061 gcaggatggg tgagcgagca cctctcgggc gacatacccg ttgcggcaac ttgctgcttc
     9121 cggcaggagg cgggtcgtga cggcggtggc gagtgcgggg tcaggctcgg tgaggtcgag
     9181 agcggtcagt ccgaggcgag tgcggaacag gtccagttcc gcagtcgtgt ccaagttgag
     9241 gtagttcctc accatcgccg tcatgatggt ctcgtcgttg attccagaca ggtgtcggca
     9301 aagggcggca aggcatgagg cgacggagtg ttcccaaggt tcagtcggga cgctctctcc
     9361 caagaaggcg taggcgccat cggggtctcc ggcaaggcat cgtccaagga cttcgacttg
     9421 gcggccgtcc aggagccggt gtccaactcc gcggtgtcgg cgtgcttggg atcgggctcg
     9481 gttccaggct cctgccgcca ccagggcccg ggttccgtct ccgagcagga tggtccacag
     9541 ccactggtga agctgttggt gctcctcgtc cgttgtggtc aggtatttga agcagatggt
     9601 gtggccgtcc acttccgcac ggccgcgggt tcgggccgcc tgaacgaggg catcgagcag
     9661 gcggtaggcg ccgttggcgt ctccgtcccg gatgaggagt cgggcgatgt tgactaccgg
     9721 ttccagggcg taccgggcct cctgtgcgct cagggactgt gcgcacaggt agacctcggc
     9781 atggcgccag cacagggtgc gtgccaggtc gggcataccg cagtcgctgg cgatcagggc
     9841 cgccttgttc tgcgctgccg ctgccaggct cagcttcccc tcatgctcgg cggagcgggc
     9901 cagatcgctt atctccctca cccgctcggc gagtggaggg cacgctgggc gagggcgcgc
     9961 tatcagtggg aagcgtcgcg ctatctggct ggcgtccaca tcactgccac tcgatgacga
    10021 tccggttcag cgggttgtcg aaggtgaatc ggcccggctt ctgctccggg gagggggcgt
    10081 cgagcggtcg gatttcgaag gcgacgttgc gggtccggaa gtcggagtcc caggtgcgta
    10141 ctgcctcggt gacgcgttcg gtgagatggt cggcgtcggg gccgtggccg atgactccga
    10201 actcgtacag cggggcgcca tcctcggcgg tgtggtcggc cttgcgccgg gtgaggtagg
    10261 tcagcgtgcc cttgtcgaat gtggcggtcg agctggcgta ggggttggtg agcagaccgc
    10321 tgtcgatggc ttcacgcttg gcgggcatac ggctcaggcc gttggggagt gcgcaggtaa
    10381 gccacagctc cagccactcc ggggactcgg gccctcggaa ggtcacgccg gtccatgcct
    10441 cggctcgcgg ctggttcagg acgtcggcga gggcatctgt gtccacggtc tggtcgccgt
    10501 tggtcaccag ggtcacgctg ccgtcctcgg tcagcgggac gaagatccgc gggtcgtcgg
    10561 cgatgcccct gcgcagcggc atgaaagtgt tcatctcgga gccgacgctg cgccagcgcc
    10621 tttcggcgtc gcgttcgaag gcgatcgagc gggagacgct gccgcgcagc cgcagggggg
    10681 agagcagtcg gccaccgggg gcgagctggt cgagccaggc aaggggcacc gcgtgggcgc
    10741 cgacggtcgc cacgatccgg tcgtaggggg cgttggcggc gtacccctga gcgccgtcgc
    10801 cgaggatgac ggtgacgttg cccaggccgg cggccttcag gccgatgcgg gcaccttcca
    10861 cgatgtcgtg gtccacgtcg atggtggtga catgcccctg ctcgcccaca aggtgtccga
    10921 gcaatccggc gttgaagccg gttccggcgc ccagctccag taccttcatg ccgggctcga
    10981 cgtggagctg ttccagcatc agggcaacga tgccgggctg ggaagcacag ctgatcgacc
    11041 gacctgcact gtcgtacttg gtgtccaccg tggtgttgga gtacgccttc tccaggggcg
    11101 cttgggggac gaagaggtgg cggggcacgg cccgcatcgc ttgctccacc cgcgcggtgc
    11161 ggatgctgct gtcctggacc agttggtcta cgaggtgggc acgcaggtca tcggggctgg
    11221 tctcgatggt gtcactgttc accccggtga cagtagtggc cgcctcaccc gtgctgggcg
    11281 tggacgcggc ggtgtcgttc gttcccataa ctacctcttt cgccagtgtt gacaaggcgc
    11341 tttggtcctc acgcgggagg cccaagcggt tccagtggaa gatcagatga tgggcgagca
    11401 cggcgcgcag gccccgctcc agtcgtcctc ggcggttcag gtgcgcgagc tgctggcctg
    11461 cccactcgaa ggtggtgacc cagtcggtga tgtacgccag tcggccgtcg gcaaccgggc
    11521 tgctgtgcgg tcccacgtcc accgtcatga gccgacgtac ggcggcgcgg tgccgttgta
    11581 acagtgcgcg gtcggggtgc tgccgttcgg cctccacccg ggcccaaaca tcgccctgct
    11641 cgtaccagtc gagtccggca gctcgcagac acgcgctgaa cagcacgatc gccaactccc
    11701 ggcgtccaag aaccggggag cctggattct gctgctgaca ggcgagttgg tccaggacgt
    11761 ggcggctgtc acggtggaag aattcgtggg cgagttccat cccgtccggg ccgccgaagg
    11821 ctgccgtctc cggttcgtag atgcccggca cccactcgcg caccgctcca tctgcgacca
    11881 gggtgtcgag agcctggtcc aggtacgttg ggtctgccgg gtccgggcgg tagcgcaggc
    11941 gccaggtcgg ggccttgcgg atgaaagacc attgccgcgt gccaccactg tccaggatgg
    12001 gtcgaaggtg agcgacggcc acgcgttcgg catcgggcca gtcggtgaac tcgatgacgc
    12061 gctgaggcca ctcgtcgtcg ggcacagggt tccctccctc tgcgactagt tgatcaggag
    12121 acaggcgttc cacacggtgg cggcggatgt gccttcctgc gtgctgtgca gagccatggc
    12181 gatacctgcg gcgccttcga gaagcccgat ggcggccgca ccttgcgggg gcgccagcaa
    12241 ggagtcagcc aggacttggg gaccggcagg gacgagccgt tgcaggagat gtggaagggc
    12301 ctgcgccaag ccggggttga tcgcgtctgc tgcggcgagc tgggtgaggt ggatgagccc
    12361 ggcgaagccg tggcacagcg aagcgtccgt ggtctggtcg agctgtcccg ggtcggtcac
    12421 tgcgcgtagg agcgtgtctt cagccatgtg ctggcgcgcg gtgtcaccca aagcgagggc
    12481 ggcgagctgc tgggcgcggg cgatgccagc ggcgccgtag caccacgacg gtcgggacgg
    12541 accgatgccc gggtcgcctg tgcccagttg ttcgcgggtg atccagtacg gccaccaggg
    12601 accggccagg ccctgctgct gccaccgatc gagccaggag cagatccgtt cgatcgcctt
    12661 gctctgcccc ggagcggtga tgccgtggaa cgttgccagg gacagggcgg ccagtggccc
    12721 ggcgatgccg tgcgccatgc cgttgttgcc atgtccgcgg gggaagtccg tgctcggggc
    12781 gcccgagggt gccagtgcgc tccaccagcc gggcagcaac tcctcgccgt cttcgatggg
    12841 ctcggtgagt cgtaccagat aggcgatcac ctgccgcgct aggtcggtgt ggacctctcg
    12901 gcacatcagc aaggcggcca tgccggacag gccccggatc gcgtcgaact cggccagagc
    12961 cggcggctcc ccgcggtcga tgcgcgcgtg cgcggccgcc aaccgtgcct ggacagtggc
    13021 ggcaaggtgc ttgtcgagcg tttccagggc gcgggagtac cggtcgggcc agccagtggc
    13081 ggcagcgtgg agggcgaagg tgagagctgg gactccgtag aacgggtgac tgtccgggcc
    13141 tccgacggcg cccccagcag cggcgcaagc cagccagtcg tgagcgcgct gccaggaggc
    13201 aaggccaatg cgggcccgct cgatgtgcag cagtgccaca ccgacggcgc cgttggccaa
    13261 ggactgaggc caccagccgt gtgtcaggtt ccatgtgcgg gcctgctccg gcgaggcgag
    13321 gcggtcggca atcagatcaa ccgccgtctg tacgtcgtag tcattctggg gggtgatcat
    13381 gcgcttcgtg ccttccaggc aagggcggcg gcgcgggcca gccggataca agtacgctca
    13441 tccgccttgt cgatccccgc agcccggatg tggtgggcat gcagcagcga gtcgagaacc
    13501 gcgtcggggt cggtaccgtc atcacaggcg cgcagccggt ctccataggc ggtcagcacg
    13561 cgggcccgtg ccgcccaagt tgcatggatg gcggtgccgc cgggggctgc acgcaggccc
    13621 gcccaatcac ctgtcgggtc ggccaggctg agtgcttcgg cgcgtaccgc tcggtccagc
    13681 gggccagggt cggtgaggtg cccgtggcgg atcagccagt ccattcccac aacggtgctg
    13741 ccagtgaagg ccgttgcggt ggcgacgagg ttcgcggcgg ccagggcctg cgggtgtggc
    13801 cgagcgggct gtgcgaaggc ggtgaccagg acggcggagt ctgcggcgaa caccgtctcg
    13861 gccgcctcca gcccgcctgc ggttccccac cggccggtct ccgggtagga ggtggcgaac
    13921 tgaacgtctc cgacgagccc ttgtcggcga agctccgtgg cccactcggc aatgcgggcg
    13981 gcgccggtgc cgaagtctcc gacatccgcc agcgccaggc gcaggcgcag atgccagcgc
    14041 gggtcgcggt agcgcgtgta ccaccacatt ggcggctgct cccaccgggc gaacaggccg
    14101 ggcaggtgat ggccgagaat ctccgggtga cgtttggcgt ggctgtagat cttggccatc
    14161 agccaccggg aggcgccggg gacgtggccg tgttcgcgcg tcaccaaccg tgccgtagag
    14221 accggcggcg tcgcacgcga cagtgcagga tggtcagctt gcagcggcac ggtgatctcg
    14281 tgggcgtggc cgtccaacca accgtccgca ccgggttgtg tctcggtcag caccgccgac
    14341 tccgacgtgg ccaggtgcga gcgcacaagc tccagatgcg ccgcctcggt gaggttcagc
    14401 ggcaatgccc tgtcgccttc agtcaatgcc acccagtccg gtacacggct gcgttgccgc
    14461 cactgctcca gagcctcgcg ccactgcggc cacgcggcac ggcggtcggg aacgtcggag
    14521 cggtgcaagc gccacctggc gggagacaga atcgtgcggc cgtaccgcac acggggcaag
    14581 aacggcaggg cgttggccgc accccaggtg aagggcgtca ccacggtgga cgttgccttg
    14641 gcgatctcca acaggaatcg agccagcggc ggggtgtggg cgcgcaggtc aagagcgtga
    14701 ggcgccatcg gctccaggcg ctgctgccgg gagagagaag ccaagaacag acgctgcggg
    14761 tcgcagccca cagccagatc gtccagggca atgagccctg cgctgccctc gacgcgatgc
    14821 tcggcaaggc tgatcacgtc gggcagcacg tccggggccc gggtgacgtg ggtgtcgcac
    14881 cgattgagag gcgtgaagga aagctggacc gggcgtgcac ccgagtcgct cgtcggcagg
    14941 tggatgaacg cctttctggc ttgtgcctgt tcttccgggt ccagtaagcc gatgaatcgg
    15001 ccggtcgtcg tgccgatgcc gcgcgagggg ctgacgacgg cgagggtgaa ctcaccccgg
    15061 gcgaccgccg caatgtcggg agcttggagg cggaaccgga gctccaggtg gggcggcagt
    15121 cgtacccggt ccggctcacc tggagtcaac gctctgacga gttcctcatc caggtggacc
    15181 tcgtcgcgcc cttcaagggc agcctgctgc gccagagcga aaaggtgccg gtccctgccg
    15241 ctcaccgcgg tgccggcttc cggctctgcg tccaggtatc cgtcggggaa ccccagccct
    15301 aggtccgcgt cgaccagatc gcgcaccggg acaagagaac cgatgccgta cctctcgaaa
    15361 aaccggttgt ggtaagactt ccaggctggc gaaccatacg ggaacgggct gagacgggcc
    15421 aacaatgaga cggcctcctc cgctgcgcgg gcaacctggt gaggcagaac gagcgtgcag
    15481 tccagccgcg cgtccaccgc aaccggctgc tccaccaccg tgctgaccgc gagcatgtcc
    15541 gtacgaagcg cggcgcgcag cctccgcccc tccaccggtc cggtgggcgc attgtgtgcg
    15601 gccagcttgc tctggacctt ttgcagccgg gctgtcagct gcgcaacatc cgggacgtcc
    15661 tcgaccccgg cccccgccat ctgttgcatc aggtgatcga aggcatcgaa ggtgcctgct
    15721 ggggcgtgca gagcactgag cagaacccct tggctgacca ggctggtgac gaggctctcg
    15781 accttggaca gcgccacctg gtgaaactcc gcgctcacct tctccaccag ttcgcggccc
    15841 cggagcggag cgcgggcggc ttccaccacc agccgtacag ccgcggtgta tcggagcgag
    15901 acctcggcag cgggttcctc cgcgcggccg gagcgtgggg ggtagggcac gacgaggcgc
    15961 cctccccgca agaacgcgca gttgttcgcc accagggata agcgatggag aaccgccgga
    16021 caggcttcaa gccgcttgat gacatcagca agccaggtgc cgtcggcccg cacgaaggcg
    16081 cggtgctgat ctccccagac cacaaggggt tcgtcggcga aggccacagg gacaacaccg
    16141 gcgaacagcc cgaacggagt cgcccttccg tgcatgcgca gcgcgtatcg cacgagggcg
    16201 gaagcagcgc gccgtacccg ccgagcgtcc tcgacttcgc ctacgcacac ggcatgaact
    16261 tgccgggcca gggccgggct ggcctgctcg acggccgccg ccagctcttc tctgtcccag
    16321 gcggcttgga gccacccacg ccaacgggca acccgatgag gggagctgtc cgcgaggtcc
    16381 ggccacgagg ccaggggaag gcggtgaccg gacgcgcgca ccatcgccgt tccggcgcac
    16441 cggtagggca agcagctctt cgtggccatg tgcttcctct cgtgagttct tccgttccgg
    16501 cgctggcttg tgaggagtca cctcctcaca agccagcgcc gtaactacgg cgcggctgcc
    16561 atcaggccac gctggaggcg catgggctgg agcaggtgct gccgcagccg tcgtcagtga
    16621 ggttgatcag cttggcggag cgatcaccgg actccaggac agtgatatcg agttcgaact
    16681 cgtcttccac gagacctcca gaggtcgagt cggatacgtc gccccggtcg aggcggcgtc
    16741 tcgtgcgccc agggcacata gggtttgggt gtgctctggg gaactggatg aacggtcaaa
    16801 ggatccaggc ggtgctcaga ccagggaacc gcgcggagcg tagcgacttc tctatgcctg
    16861 acgatcggtt cccggtcagc tccgggtacg caggccgcgc ccagctgtag gccgttttga
    16921 gccttagcag tcatcgcgct ttctggacgt cacaccagtt cgtccgtaat ggcgaacact
    16981 agataccgct cgggtcaccg ggacccggca tcaaccggtg ccccgagcgg ggtctattcg
    17041 acggaccgtg gtccgacgcg ctgagcacgg tcttccagcc cctcgaccag gccggtcgtc
    17101 tcattggcgc ggaggtggtg agagatgcgg gcggcagcct cgatggcgac cgtgatcact
    17161 tcatggccgt acgaggcttc gcggcgtgtc cgctggaagt ggctggacag cgacaggacg
    17221 gcggccagtt ccccatcacg gccgcgcacc gccaccgcca gaaccaggcc cccgtcggca
    17281 acgccctcta cccagccgcg acaccgtata gcggagcact cagcggcggc atccctccag
    17341 acttcacggc cctggctgag ctcctgccag gcgaggaaga cacgcgagac ggggtcatct
    17401 cccatcgccg ctacccgggc cggcttgcgg tcagtggccg ccgagttgag tcgcgggtcc
    17461 tcggccatgc agatccgctg atcgtcacaa cgccgttcga ggcggacaga ccgtacgccg
    17521 gttgtggccc gcagcgcgcc gagttgctgc cgcagttcac ggtgaacgat cgcctggtgc
    17581 accgcccttg ccaggcgaat cagcctcgga ccgacaatga actgctcctg ttggtcggac
    17641 tcgaccaggc ccagctcctg catagcgaga acgagtcgac gcaccgtggg acgcttcagg
    17701 ccggtttcgg aaatcaccgt ttccagatgc gccggcccct cttccagcac ggcgaggatc
    17761 gcagatacct tgttgagcac accgacttgg ctctgcacca tatctggatc agtaatcgcc
    17821 atcatctccc cttgacaggc cagccattcg agcgcgcgga gcaccctcgg cctcatgact
    17881 gcattgttct ccgtttgctg acgctctaaa tctccagcgc ctcatcacga gaatacgatc
    17941 cgccgcgtgg acgcagctcc acacctgatt cgacgagcat tgcgcgaata gatccaaatg
    18001 agcgccctgt aacttccctt atatccctga tggtcacgtc gaggttgttt tcatagacgg
    18061 ccttaatgct ctcgcggaag cgttcgcggt ccttcccgat aagcctcttc cctcgtggaa
    18121 tacgagggag atcttccaac ttggcagtca tggctacatt ccccaaggcg gttggctcgt
    18181 acttcattgc ggtcacagaa gacccagctg cgatcgtgat agatgagcgg ctgaggcgag
    18241 tgtctgagag cagagaaggc gtcactcatg aatagctgac tggctgagtc ccataaggag
    18301 ttctccctgg gccccggacc gccgggagac tggagcttca tccggcgccg gtccgagtac
    18361 gccgagctcc cagccacgac ggataagatg cgccggggtt ttggcgccca ccagtgccat
    18421 cagcgcacgc acgtctctgc gtacgacgtc cagacgcacc ctgccgttcg cagcgatcca
    18481 tcgcagatcc tgaccgcctg ccaagccgcg cagaacttcg tgctgacccc cgctgagcac
    18541 gaggtccgca ccgtcatttg tgtgctcggg cggggagatt tcccccagcg tgtaggcccg
    18601 gtgcacggca cccggccgtt cgggggagcc gagcttcacc aaggcgaacc gtaggcagtc
    18661 gttcactctg gatgtcccca cacccatctc cgcggccgct tgtgccggcg tcataccgct
    18721 cgctatgagc tgtagggctt cgcgctcgcg agccgatagc ctccatcggc ccgacggttg
    18781 gctggtcaca acgacccttt ctcgtttcga tacgtatcgg tgtactggca cgggatgacc
    18841 ggctcaggca gcggtgtgct ccgtcagatc gccaaggtcc acagccgtgc agccgtggag
    18901 cgcgacgacc tcgcggcagg cgagggtcca gggcagtcgc gggtcgtcgt acgccacgag
    18961 cgtgaacggc tcaccgtgct cgccgggcac cggcctgaga gtctcgggcg cgtgcaccac
    19021 cccggccacg ccccaggctg cggcgtgctc caccagcacc gccacacact ccctccgcac
    19081 ggaaggacgg ctcagtactt caagggcaca gccatcgcat acaggcggtg tggccgtcct
    19141 ctccccatct gcgaccggct tgccgctggt ggcatgcagc aagaacagat gccgcccatc
    19201 gggccggtca tcagtgggcc ggccgcagaa ctgacacagc atgtgattca tcgccagccg
    19261 ctgacgcaaa gcgtgcacac gtccgagcag aggcgcgcca gccccgtgcc tgaccggcac
    19321 cctgatccac agcgcgccac gacgacggtc ggcgataccg tattcgcctg cgtaaccgat
    19381 gcccataccg ccgcgaccgt gccgcgtcgt gatcacggcc ggaggcgcgt tctcgcctgt
    19441 ccacgcagcg atgtacggca cacgcacacc gcccgcgaag tactgacgtg gtcgtggacg
    19501 ccgaggccca gcactgggac ggtcaggcgg cagccagccg gtgggtgacg tgcactggtc
    19561 ccgacgcata ttcgtcctct cggatgtgtg ctcgttgcgg gtaaagcccc tcttcggcgg
    19621 cctctagact ccgcggggga acgggatgaa aacgccgaag agggagtaga aggtccgcat
    19681 cacacctggt ctagccacag cccctccctt cctggcagtt ggagcagggg cggcggccag
    19741 ccctcaccag acgtgaacgt ggtccagttg gcacggtcat gaagtgacgt cgatcggcct
    19801 ggcccgaggg aagccctccg tcagttgtcg acttcctgga cgctggccgt cgagaccacc
    19861 gccatcacgg tctgatgcct gtttcgcagc gcggatagag acgcagcgcc tcttccagac
    19921 aggagataag gacgaccgca ctgggcaact tcagcggagc tcgttcggtg gggtgccacg
    19981 gcggagtgtc ccagcggacc ccgctcgtcg gcggcagagt gatccgtgcg tcggcaccag
    20041 ccatgacctg gacgcccgcg agtgcggaga cgtgtatccc gctgccgcgt gcaaccagga
    20101 acgtgcccgt ctcgccacac aagaggcatg gcagggccgt acccctccga tccagccgga
    20161 ccagcgcaga tgtggcggct ttgcgcggag tggtaaccgc gtcgaacttg gtgcaggcgg
    20221 ccaacaagac tgtgctggag ttacgggcga aggcatgttg cacctcgtgt gcgttcatca
    20281 actccgcgtc gataaacagg ggccagccga gtaggtccac atctgcgtat gtgtccacta
    20341 cggcgtcccg gcctctcggc ggccacacag aagtcgtcat caaggggtcc cccaaggggt
    20401 gtgcatcgcc ccgacgcggg agccatcttc cggagccaat ggttcaccgg acccgcccgc
    20461 ggcgatctgg aagctggtct ccatcaggtc gcgatcgcac tgcttcccgc tgggcaccgc
    20521 gccaccagca cgctcaccgc tcagttgccg gactgatatc agcgaagacg gagcatggaa
    20581 gctctgggag tggatgctga cgctcattgc cgccctcgcg cccagcgatt tcgcttctca
    20641 tacgtcatgc actcacggac tccctgacac tgctcattgg tagggcgcat acgtggtcac
    20701 cacctgagta gtcgcttgat cgctcactgc gattaagctg gacgaggtgt gcgctgggtc
    20761 accagctgtg gatgaactta ctgtgaccaa gcgggcaaaa aaaactgaca cagagtacga
    20821 gttgcacacg cccaaccacg tgggagcacg gcatggcgcc acagaagcga tcgcgctccg
    20881 agacgggaac actgactgcc ggtcagggtc cgccaacccg cactgcgagt ggcatcgtct
    20941 gcggccatct actcaagatc atccgcgagc gcattccgct gactcagtcc cggctggccg
    21001 aagaactcgg tatcgacacg acgaccgtcc agggctggga atcaggccgt cgttccctag
    21061 cggctatctc ctccgcgcaa ttcctgcgtc tgaagcgaca tctgctagga cgcggtgcgg
    21121 agccaacgct tctgcctctc ttggatctcg cagtcgaggc cgactccgtg atcgagtact
    21181 cgctcaacga cacgctcaac agtgacgaca tcacccaaca cccgctgcac agctgggtct
    21241 ttacccgggc atcgactcac atgatcgctt gggccctgac cggtgagcag cccacgattc
    21301 tccccaaagc ccccgcgtcg actccccgac ggagaggccc tacgcctggc tcgccactcc
    21361 tgccaacccc ccagcgagac aagctgttcg ccaatctccg ccgcacagcg gagatcgctg
    21421 accgggcggg ggaagatggc tcgcttctgc gccgacaggc gctctacctg tgtgcctacg
    21481 acaccagcgt cgacacccat tcctggctcg ctgacatgcg ggaacgccgt caaccgccac
    21541 tgcgtcacgc atcgtggaca ccagcctggt ccgacgccag gtcggtagca acgtccctga
    21601 cccgctacgg agacagcgag acgttgcaga cattcatcga gcggggcatg ggaggagacg
    21661 ctagcgagat ggccaacctc aattactggg cgcactggct gggtctcgac ccggtgcccc
    21721 gtgcaagcga cgcgttcatg agcgacgtgg acggccggtc ctgggaggcc ctcccgctcc
    21781 ttcgcaacct tgccgaccgg cttgatccgt cactgggcgc ggtggacttg aacatccact
    21841 cggtgtgggc gctgatcagc tcgaagcccg gtgttctgtc agctgaccgg gaactgcacc
    21901 gcgacttgac ctcccgagtc gaccgcctgc tcgacagtga tgtgatctca cgccagtcca
    21961 ggcgtgagct ggagaatgtg cattacggtc tgagactgag tagccggtga tccgcttgaa
    22021 ggggacgatc tgcatgactg atgaccaggc tgacaaggga actgtcggct acctgtttga
    22081 gatgggtgcc ctcaagcggg gaaagaggag tggctggtgg atcgcaggcg tcaaggaccc
    22141 cgagaccatc gccgagcact cgttccgcac cgcgatcatc ggcgcggtgc tggcgatgat
    22201 ggaaggcgct gacccagcga aggtcgccct tctgtgcacc ttccacgaca cccaggagac
    22261 ccgtgtcggg gacatcccgt ggatcgggcg ccgctacctc gaagccgcct cgaatgagcg
    22321 ggtcactgcc gatcaggtct cgaagactcc tcctgccgta gcggagggga tcaaggccgt
    22381 ggtccacgag tacgagaacg gcgactcact ggaggttctc gtggcacacg acgctgacaa
    22441 gctcgagtgc atgcttcaag gcatggagta cctggagcag ggttaccgca atgcccagga
    22501 atgggtggac accacgcggg cgaaactgaa gacgccctcc gcgctcgcgc tcgccgaagc
    22561 ggcgcaaggc atgtcgtcca tggaatggaa gcacacgtat ctgggctgac cagcacgtcg
    22621 catctgcgcc tggactgcgc cccgacccaa caaccaacct tccaagcaac tgtcggcctc
    22681 gggcgttgcg tgcttgagca gtccacccgg aaggggcagc taccggtaac gacgcgacgg
    22741 aaccatgaat gacgtcgcca gagtgttccc ctccccgtct ccatcctcgg ggtcatcggg
    22801 ggccgaggtc tgacatatgg cgtcgatctg tcgctcgatg ccgcgcagat tctcctgcaa
    22861 gtccatggtc acgacgccgt cgacggtgac cttcagcggg tcaccgagca gcttcgctcg
    22921 cctctccccc agcacctcta gcgccaccgc acgagccgac cgtagccgga agaaccggcg
    22981 ctccaggtcg gctgagtccg tgtccggtcc gagctgcgcc agcagccacg accgctggaa
    23041 ctcatccacc tgcctgccct tcctcttgta cgggaacggc ccgccaccga ggcgttcccg
    23101 gtggcgggcc gaaggtcacg acgacgccga agcagaccga gcgcggcgag gcggcgactt
    23161 cttcgcactg cctccgccac tctccccagg ctccaggtcg accgtcttct ctgcggtcgg
    23221 gtccggctcg ccgaccgcga tcggcagcga cccccgcccc tccggcggaa cttcccacgc
    23281 atcggggttg gtcaccaagg cggcgaggcg cggttcgggt tcctcgccag gcaggaggat
    23341 cagctcctcc cgggtggccg ggtcctgtac gtacacggcg gcttttagtc gaggcactgg
    23401 catcacagga ccttcgccac gatgtgcgca tccggagtgt gcatgaccgg catgccgacc
    23461 gccgcaccct tcgtatagat ctgcaccgga tcatcctgga ccccacgggt gatgatgatg
    23521 cccggcgcat cctcgcggat gatctccggg ttcgtgcccc gcgagagcac cagcgcctca
    23581 gccgtcacac cgatctgcgt ctgcgcccac ttctcccggt ccggcggtat caggcaccac
    23641 aggtcttccg gcagcacctt gcgtggcttg ccatccaccc gcacctgcgc cttgtagaac
    23701 gtgatcggcg gcagcgaata gttgccgcgt accacgttga tctgctgcgg ggtgagcgtc
    23761 gccgtcggcg tggtcgacgg gttcacgctg ccgtaatacg ccgcccggta ggcgttgttc
    23821 gccgccaggt aggagaacgc cttccggctg gtgaccacta gttccggttc cggcgcgccg
    23881 acgtcgtcca ggtgctgaat ccaccggagc tcatcggcga tcggatccga tgccgggtcc
    23941 caccacggtc gttgcgcgac aggcatgttc gccgcgggga cgttccagtc gacctccagc
    24001 gtcagaccgt tctcctgcac cagcgagaac ttcccgtccg ccagcacgtc gccggcagcc
    24061 atctccaggc gtgactggat cgcctccaca tgccgctcga catcgtcata cagcaactcg
    24121 atcagccggt cctggtccga gccgtgcgag gcttccagca ggatctgttc ctgctcggag
    24181 accatcagct tctgacccag cgcgggcagc gccccctcac gggaggtctg ccacgcctca
    24241 cgggtggcga acggcacgct cgcgttgaac gcccggtact tcgccacgtt gacgtaccgg
    24301 cccgagtcct tcacccgcca cttgacctcc cgcagcccgc accgccccag caggccagga
    24361 gcagcacaca gcgcagacct gcacgtgaca ctgtgccccg tcccaccgct cggtggcacc
    24421 cgttccggtc gcggggcgca ctgctgcccg gttgtgagac gtagtgatta aggcgtgagc
    24481 tgctcgattc taagtcgaat aacaatcccc acgaggattc atggtgagtt agcgcacagg
    24541 aagcactgta agggcgatat cacttcgcta cggtggagcc gtcacagatg aagcgacgag
    24601 gcgagcagaa ggcgatctac gatgagcagc gacgcgccct ggacgatcga acgtattcgc
    24661 gatgctctcg gtgaccctga cctagcccag cggttcctca gcgagatcaa ccgggcgccg
    24721 gtccatgagc tgctgtcgac attcgcgcgc tgggaacaca tcgccaagaa caccctcgca
    24781 accgtccagc gagcccgtga gctggcaacg catgatgccc gcgacgaaga gcccctgggg
    24841 gaatgggtag acgccacaga gcgcattcag cgggaagccg agcagatccg gggctacggc
    24901 gccgcctaat cccacaatca ggttacgctc cgcgtcagat cgactacgct tcccaaaggg
    24961 ggctggcaga tcgataacgc gcatcacatg cgcatggacg cgaaggacca taacaccggt
    25021 gtatcgcctc aagtacgacg ctgctgccag ggccgtccac gacgcgttgc cacccgaagc
    25081 gagggaacaa ctcacccttg ccctcgccga cgcgtgcgag gaccccatcg cggcaaccaa
    25141 aacgctacgg gctcgtggac gacggcgtca tgcgcaagat cctcacccgt gacgtcctcg
    25201 cgatcctcct cataggcaac ggcctcaagg agctcaccgt cctccaggtc gagtacctcg
    25261 gctgaatgaa tctcgaagcc cccggccaac gcggtcgggg gccatcgccg cccggcttgg
    25321 ctcccggaac acccccacga cggcgggagg acaggaaggc accggcgttg acggctgcct
    25381 cctctggaac acccccttcg gcggggagga cgtggtccaa cggcggtgga acaggtgacg
    25441 gatcggaaca cccccgcgtc ggcgaggagg accgcacccc cgccgtcggc ctggccggac
    25501 ccggcggaac acccccgcgt ccgcggggag gacggccgcc cgtcttcggc gcggccccac
    25561 ggggccggaa cacccccgcg tcggcgggga gaacgatcgg gcgacctgtc cagcagacgg
    25621 ctgtcccgga acacccccac gtcggcgggg aggaccactg gacccgctgc gggcaaccac
    25681 ccgggcacgg aacaccccca cgtcggcggg gaggaccggg ccccggaggt gatctgggag
    25741 cccatggtcg gaacaccccc acgtcggcgg ggaggacgtc gtgggaggag gtggatgtgt
    25801 ggtcctgcgc ggaacacccc cacgtcggcg gggaggacgg aaacatgctc tgccattctc
    25861 tattccccct cggaacaccc ccacgtcggc ggggaggacc gggggatggt ttaccgacag
    25921 gacacggtgg gcggaacacc cccacgtcgg cggggaggac gccactccgc gatctcctga
    25981 gagatcggca gccggaacac ccccgcgtcg gcggggagga cgaggaggac ccaggagagt
    26041 tggtcgtggc tggcggaaca cccccgcgtc ggcggggagg acagcccctt gctgtccgag
    26101 gcgtccttga ccaccggaac acccccgcgt cggcggggag gaccctttct gacctgcgac
    26161 ttagaaacga ctttgcttgt tctttgccat gtcggatgag gtgaaacgct ccaggggctg
    26221 cacgatgccc actttatccg gggcacgctc ggggagggca acgctcgatg gcgaggccgt
    26281 cggatgacag caggcgagtc aaggtgtcag tggtgagtgc ttggatcagt cggcggggcg
    26341 acctcccacc gtgtggcggg acgcgagcca gtgctgaagt gggaggaaga cgtcatgatg
    26401 cgcaagcaag atgcgttaga tgagtcggcg tgggggaagt cgcggggcct ggatccggag
    26461 cggcctccg
//
