LOCUS       NZ_CP019458            22535 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces autolyticus strain CGMCC0516 chromosome, complete
            genome.
ACCESSION   NZ_CP019458
VERSION     NZ_CP019458.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces autolyticus
  ORGANISM  Streptomyces autolyticus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10029028)
  AUTHORS   Yin,M., Jiang,M., Ren,Z., Dong,Y. and Lu,T.
  TITLE     The complete genome sequence of Streptomyces autolyticus CGMCC 0516,
            the producer of geldanamycin, autolytimycin, reblastatin and
            elaiophylin
  JOURNAL   J Biotechnol 252, 27-31 (2017)
   PUBMED   28472671
REFERENCE   2  (bases 1 to 10029028)
  AUTHORS   Yin,M., Jiang,M. and Lu,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2017) Yunnan University, Yunnan University, 2#
            Cuihu Beilu, Kunming, Yunnan 650091, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Analysis v. 2.3.0
            Genome Coverage                   :: 279x
            Sequencing Technology             :: Illumina; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 03:05:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,227
            CDSs (total)                      :: 8,141
            Genes (coding)                    :: 7,920
            CDSs (with protein)               :: 7,920
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 221
            CDSs (without protein)            :: 221
            Pseudo Genes (ambiguous residues) :: 0 of 221
            Pseudo Genes (frameshifted)       :: 74 of 221
            Pseudo Genes (incomplete)         :: 182 of 221
            Pseudo Genes (internal stop)      :: 9 of 221
            Pseudo Genes (multiple problems)  :: 42 of 221
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:31:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3789684
            Orig. end                         :: 3812219
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP019458.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22535
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="22"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22535
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22535
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12535](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12535
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            complement(766..1461)
                     /gene="ribA"
                     /locus_tag="BV401_RS15125"
                     /old_locus_tag="BV401_15075"
     CDS             complement(766..1461)
                     /EC_number="3.5.4.25"
                     /GO_function="GO:0003935 - GTP cyclohydrolase II activity
                     [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0009231 - riboflavin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ribA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007383060.1"
                     /locus_tag="BV401_RS15125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15075"
                     /product="GTP cyclohydrolase II"
                     /protein_id="WP_079153428.1"
                     /transl_table=11
                     /translation="MIEPRDDAHPQAEAEPSVSLLDGDTGALPAARIRRKVRIPLHHGS
                     AEPIAADVMTFGGLLDGREHLALRLGPRHPEVPLVRVHSECLTGEVLGSARCDCGPQLR
                     EAMRLINTAGGTLLYLRQEGRGIGLYNKLDAYSLQDQGLDTFSANRALGLDDDLRDYGV
                     AAQMLRALGEVEIDLLTNNPDKREQLRHYGIAVRHTVSTGVYANPHNRGYLTAKVARTA
                     HTIRLEESA"
     gene            complement(1458..2882)
                     /locus_tag="BV401_RS15130"
                     /old_locus_tag="BV401_15080"
     CDS             complement(1458..2882)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="BV401_RS15130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15080"
                     /product="MFS transporter"
                     /protein_id="WP_079257448.1"
                     /transl_table=11
                     /translation="MTDAGTAEEAGSVTPDGAGAHAADESVEPNPLADRRFLVFAAGNA
                     ANNVGEALYATALPLLAYQLTDSLVVMAWLAAAVPVSDLFAPALGAWADRRGVRGLIVQ
                     GLLAQAGAALAMNLLLLGGHSAPWLLFLCAVVLETGGLAYRTGWMTGVPAQFPDCPVRA
                     RGTLNSLFLATTLAGPLLVAALLPWVGYQGLLWLNLPTFFAPLVVWAVGVRPARSAPAS
                     PHKTAPAPSHKGGRTDGGPRRTAPRWVKRRAAGAQARAGAEAPPSRIRDGWDAIRQDKR
                     ISVMLVADMVLSAVCGTGLTSLIVYHLRHGWALSGQQAGLAIAGMNVASLVGNLLVSQR
                     RRLRPWTPMTLGVAARSVALILMIVPVWPVFMFAVVLGALGQGAVMATVVMARVRYLPP
                     GVLGRASGLIWLLTGGAALLSPVFVSALDDVVGTPPTFLVLGIATTTVLLHLRLTRAAW
                     RPVPRPQEPARRTNEP"
     gene            complement(2879..4843)
                     /locus_tag="BV401_RS15135"
                     /old_locus_tag="BV401_15085"
     CDS             complement(2879..4843)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1173: WD-40
                     repeat-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF024753.4"
                     /locus_tag="BV401_RS15135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15085"
                     /product="PQQ-binding-like beta-propeller repeat protein"
                     /protein_id="WP_079257449.1"
                     /transl_table=11
                     /translation="MGALERITRIVSQPGHGLLACDVRGGLHWLDRNLNIRVSSPLPAT
                     AQAPSGDPVYAVKVVGDWIITRDKAGNICRWDTETLRLSDRLDAASTANTEHLLEGEQP
                     SPTMLRGIGVWQGKAYLNNGYFQVVVLDVESFTVDRISLWPHGYDMLEWFCTDAPGVHA
                     VSDRSGHIHLGSLPDLDFPTVVQVDTSNVHRVVYDERHDRYWAICDAGLGPTRNISNGV
                     VTLGLDGEIDQRMDIARNDVEGLVFSPDFSRAYIGGFDGELVVFDNSTPRLRIEQRIRG
                     FSHQIIDVTVDEDGRIYTLTQDGEVTALSPQGKVLTRLGHPRQCVWDIQPHPAEPGALV
                     VATDDGAFEARMRTSPAGHASLEVTGRHRTGLGFSRRIRAASDDLVGAFWPSRLRRFTT
                     ADTTVWEAQLPGIIHTVAVSPDGGRVLAACNAGGYEFDAATGEPTWQVEDLPASAWACA
                     YLDDGRRLLATRNGQLTAYGDQAEPSWYAELNSYPKRLITDGDRVRITGGGGVKEIVVG
                     EDKPTRQFTELLDNTAENCVLIDGVLCVVTYGMQVAAFDYDTAELLDFHEDLPDFGKGM
                     AALHGPDGRAYVVVGGRGGFLRLYLMERTGGGRVLTPLRDLWLPLSDRPVSSAGTTGSA
                     GTTGSAGAAGAADEEAAVR"
     misc_feature    complement(5138..5151)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     misc_feature    5433..5448
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.3"
                     /tool="antismash"
     misc_feature    complement(5458..5473)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.79"
                     /tool="antismash"
     gene            5537..6124
                     /locus_tag="BV401_RS15140"
                     /old_locus_tag="BV401_15090"
     CDS             5537..6124
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015325.4"
                     /locus_tag="BV401_RS15140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15090"
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="WP_158525896.1"
                     /transl_table=11
                     /translation="MTRIVLISGSLRHDSLNTMAIATIERMLTARPEPAAAVRLAIEEL
                     PYYHQSDDESGKRHEAVHAARHLVTASDAVLISTPSYNGLVSGVLKNALDWLSRPWGDS
                     ALTDKPVAMLSASTSARGAMEAQSGLRTVLERSGAVLIAAPQVALARADAIAAEDGRFT
                     EPATVAALEALVEALLAHLSPEPAAIHGISSL"
     misc_feature    complement(5542..5557)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.53"
                     /tool="antismash"
     misc_feature    5550..5564
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.22"
                     /tool="antismash"
     gene            complement(6132..6983)
                     /locus_tag="BV401_RS15145"
                     /old_locus_tag="BV401_15095"
     CDS             complement(6132..6983)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020138523.1"
                     /locus_tag="BV401_RS15145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15095"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_069869360.1"
                     /transl_table=11
                     /translation="MDRRELAGFLRSRRERITPADVGLPAGPRRRTPGLRREEVAQLAF
                     ISTEYYTRLEQARGPRPSREVLAGLTRALRLSDAERAHLHYLAGAPPAPPPGPSREVRP
                     SILDLLRRLPHAAALVLSAAYEVIAHNDLAAALLEDFSALPRHERNFLRRTFLDSSAGE
                     RQWYSRSGMEIFGRTAARHLRAAAARYPDDPEVAALVKDLLAGSAEFARLWAAYDMSVE
                     PAPQKTFRHPLIGPITLNCDVLDIADRDQRVVIYTADPGSPAEGALRLLSVIGTQRLDV
                     PG"
     misc_feature    complement(6645..6647)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7072..7905
                     /locus_tag="BV401_RS15150"
                     /old_locus_tag="BV401_15100"
     CDS             7072..7905
                     /NRPS_PKS="Domain: PKS_KR (30-194). E-value: 1.4e-12.
                     Score: 39.8. Matches aSDomain:
                     nrpspksdomains_BV401_RS15150_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644845.1"
                     /locus_tag="BV401_RS15150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15100"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_079257451.1"
                     /sec_met_domain="adh_short_C2 (E-value: 1.2e-29, bitscore:
                     102.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTTPTTHTTHTTHTTDTSAPAAPGLLAGKVAFISGAGRGIGAAA
                     ARLFAREGARVLLAARTEDQLKAVTEQIRAAGGTAEYAVCDLADATSVRAAVDRTVEAY
                     GRLDAAFNNGAIGTRRPGPMDQVPEADFDEQYGVNLKGVWLALAAQVAAIRATAGTGAI
                     VNTSSVGGWKGNPVLPAYSAMKRGVHSLTESAAVAYGPEGIRVNAIAPGTTLTEMMRHW
                     DAESPGTIDQLNARTPLRRAAQPEEVAEAAAWLLSDRASYITGVVLSVDGGMRAS"
     aSDomain        7162..7653
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BV401_RS15150_PKS_KR.1"
                     /evalue="1.40E-12"
                     /label="BV401_RS15150_PKS_KR.1"
                     /locus_tag="BV401_RS15150"
                     /protein_end="194"
                     /protein_start="30"
                     /score="39.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VAFISGAGRGIGAAAARLFAREGARVLLAARTEDQLKAVTEQIRA
                     AGGTAEYAVCDLADATSVRAAVDRTVEAYGRLDAAFNNGAIGTRRPGPMDQVPEADFDE
                     QYGVNLKGVWLALAAQVAAIRATAGTGAIVNTSSVGGWKGNPVLPAYSAMKRGVHSLTE
                     S"
     CDS_motif       7171..7245
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BV401_RS15150_0001"
                     /evalue="2.20E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="BV401_RS15150"
                     /protein_end="58"
                     /protein_start="33"
                     /score="10.7"
                     /tool="antismash"
                     /translation="ISGAGRGIGAAAARLFAREGARVLL"
     gene            complement(8135..9502)
                     /locus_tag="BV401_RS15155"
                     /old_locus_tag="BV401_15105"
     CDS             complement(8135..9502)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018521721.1"
                     /locus_tag="BV401_RS15155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15105"
                     /product="hypothetical protein"
                     /protein_id="WP_079260435.1"
                     /transl_table=11
                     /translation="MTKCTPNHQLRNLVAESGLTYEALAKEVRAVAAECGAALRTNKST
                     IEHWISGVVPAGDTGRYLVVALSRQLGRLLTLHDLGLGPHEEGDDSLGLSLGEDPLDAL
                     LPMWSHELNRRRFLSTSAYSVAAAGLPLSYVREIADRTAAARAGQTIGMAEVAAVRDMV
                     RLFSEMDERHGGQHGRSALVQYLRDDVAPLCRGRFRTDEIRQQMLSAAGRGVHLLGWKS
                     YDAGQQGLAQRYYLQSYALAVESGVPGHDGFVMRTMAMQGLKLHRPEHCQALAETGLNR
                     AKGKVDVQTESLFRVVHAHTLAKSRQRQAAVVEVERARTLLAADCGDEMPFWALAWGPP
                     AASVYSRNAKVYETLGDRRNAAEQYARAAASRPASYARIVALDLVASAEMQLKGGSIEQ
                     ACATWNRAMDHMDGVRSVRTRKAVTGMRSGLARFRARGVRCAADLDERAVEFLAAT"
     misc_feature    complement(9386..9388)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            9705..9833
                     /locus_tag="BV401_RS42770"
     CDS             9705..9833
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BV401_RS42770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_142881440.1"
                     /transl_table=11
                     /translation="MNTQTAAPVYTAPVVLDAGDVVKVTLGTNNFDTADDTQYKNA"
     gene            10001..11839
                     /locus_tag="BV401_RS15160"
                     /old_locus_tag="BV401_15110"
     CDS             10001..11839
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033561.1"
                     /locus_tag="BV401_RS15160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15110"
                     /product="albusnodin/ikarugamycin family macrolactam
                     cyclase"
                     /protein_id="WP_237288260.1"
                     /sec_met_domain="Asn_synthase (E-value: 6e-27, bitscore:
                     94.1, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRWSTGWYGASRHDRLPRSRKPVPGLAAAWTVGWATGQVRSAGSG
                     PLALAVIGDCGADDQQLHQALTTVRARNWAALTRWPGSYLTIARSGESLAVIGDLACQH
                     CVYLRSEGTGTWWSTSAGALAALDGAPFDPTALAAHLALAQPDVLGHRSLFRAVSRVPT
                     GHLLLITPDGANTIRYEPVDYQPISLPDAAPRVRAALSEAVDTRLDGMRAVSADLAGLD
                     STTLACLAARRGPVTAVTFADARLRDDDLSYAVRTAAAVPELTHHAVPGRAETVYYSGL
                     DDLSSLPLTDTPNAYAVTAGIKRAVLGAVAERRSATVHFTGAAGDAVLSAPSSYLSDLL
                     RDRRYRRAVAHAHAHARLRHVSPLSVLRRARPASRVGLAGAWLQAATELRDTPRAWMPQ
                     AERPVAWAPLLATADWMSREVRHQLAEALDIAAGELLEEPRQLAAWTDRQDLARLGADT
                     AGLRELARADHATEIAAPFLDNEVIRACLAVPADQRGAPGRYKPLLGEAFARTGLLPDF
                     VLSRATKGGFNALAYAGLTQHAAVLSQLLGPSSRLSAAGLISQPPVERMLRRAAAGQPT
                     AQGALHLAVSAEIWLRQMETTNAASWWEVVGHVAAA"
     misc_feature    10445..10447
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11823..12116
                     /locus_tag="BV401_RS15165"
                     /old_locus_tag="BV401_15115"
     CDS             11823..12116
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017239.4"
                     /locus_tag="BV401_RS15165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15115"
                     /product="PqqD family peptide modification chaperone"
                     /protein_id="WP_079257453.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 4.9e-11,
                     bitscore: 41.4, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWQLREGAHAVLADEGGAILDERTGHWTLLAPTAAAAVMILLATT
                     TEDQAAGQYATRYGIDAARATADVRTVAHVLMARGLAITEHAHHRRRWGWLR"
     aSDomain        11826..12071
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BV401_RS15165_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="1.70E-13"
                     /identifier="RREFam002.1"
                     /label="BV401_RS15165"
                     /locus_tag="BV401_RS15165"
                     /protein_end="83"
                     /protein_start="1"
                     /score="41.4"
                     /tool="antismash"
                     /translation="WQLREGAHAVLADEGGAILDERTGHWTLLAPTAAAAVMILLATTT
                     EDQAAGQYATRYGIDAARATADVRTVAHVLMARGLAI"
     gene            12113..12535
                     /locus_tag="BV401_RS15170"
                     /old_locus_tag="BV401_15120"
     CDS             12113..12535
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033537.1"
                     /locus_tag="BV401_RS15170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15120"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_237287628.1"
                     /sec_met_domain="PF13471 (E-value: 9e-14, bitscore: 50.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSMEAYSTARAGTFPERCAAAAGLALALVLLRLPFRFTVRAVRL
                     ARRVGCRRPTATQADVLITAVRHVGRLWPGRAACMETSLGAVLAAALLGRRLNWCLGVR
                     FSPPPVEYHAWAELPDHGPIGEYTEVGWHHHTALTI"
     gene            12623..13675
                     /locus_tag="BV401_RS15175"
                     /old_locus_tag="BV401_15125"
     CDS             12623..13675
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013315.4"
                     /locus_tag="BV401_RS15175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15125"
                     /product="protein-L-isoaspartate(D-aspartate)
                     O-methyltransferase"
                     /protein_id="WP_079257454.1"
                     /sec_met_domain="PCMT (E-value: 7.3e-22, bitscore: 77.0,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTIADIAETVPERHYTHHEGRGATPHRSNPVVIHRELTTLDVPP
                     GTNVAEFGTGSGYSGALLAQLVGPTGQVTSLDIDHYLTRWANLIHHDRGLRNVRCYTAD
                     GTAGFPSRAPFDRVVAWCTPPLLPEAWVSQMVDGGLVVAPLPIAAVPNMTVVARIRVRN
                     GQPDVEAIFTGGYIEATASPKGDLDLPGRWVDWENRVPAPSWISVGWRDKDNWRNSGAR
                     ATLDRLVKDAHIEPYDGPEVDWPSWRTFVAAKGNPYVTMAGLSPDLWALGHSTPTTAAV
                     IQQDGMIVADCSDSPSLAVLRGWLSEWEAAGRPAPDVHTPILVRRDNGQGPSGWDLRLI
                     DPSGTCSLRR"
     gene            complement(13983..14489)
                     /locus_tag="BV401_RS15180"
                     /old_locus_tag="BV401_15130"
     CDS             complement(13983..14489)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009080711.1"
                     /locus_tag="BV401_RS15180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15130"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_257788917.1"
                     /transl_table=11
                     /translation="MATRMFVSADTEPSMRAVAREAGVGIATLYRHFPNRESLVDAVYR
                     DQVARLTAGARELLAQLSPPAALRRWMDLFGEWIATKNGMLDTLLAMIESGEIAHARTQ
                     TELLAAIDDILDAGRATGELRADVTAEDIAASLIGIFTVAPSPEHEARAGRLLNILMDG
                     LRPTP"
     misc_feature    14582..14597
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.33"
                     /tool="antismash"
     misc_feature    14594..14614
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.81"
                     /tool="antismash"
     gene            14657..15625
                     /locus_tag="BV401_RS15185"
                     /old_locus_tag="BV401_15135"
     CDS             14657..15625
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (26-205). E-value: 2.5e-28.
                     Score: 91.0. Matches aSDomain:
                     nrpspksdomains_BV401_RS15185_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014043542.1"
                     /locus_tag="BV401_RS15185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15135"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_079257456.1"
                     /sec_met_domain="ADH_N (E-value: 8.6e-08, bitscore: 30.9,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.3e-10, bitscore:
                     40.2, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQEPSVNTSATTSRAVRLESFGGPEVLNIREVPAPQAGSGQIRVR
                     VTAAGLNPMDWFMTSDADTATRFGLSLPSGFGTDYAGVVDQVGHGVTEFAAGDRVFGGA
                     LSRAVADYVVIDVAGTIAAGGDAHHTPDGVDDRTAATLAIAGCTAAAALAIVNPGPGDT
                     LLIGGAGGGVGVFAVQLARLAGARVIGTGSATSADALRALGAEPVAYGDGLADRLRALA
                     PTGVTAAIDLFGTDTVRAARDLGVPDERITTIAAQVDGITPANGANAAPGAIEEIARLV
                     AAGRLRVPIAASFPVERIRAAVELQAGRHVHGKVVIDLQPY"
     aSDomain        14735..15271
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BV401_RS15185_PKS_ER.1"
                     /evalue="2.50E-28"
                     /label="BV401_RS15185_PKS_ER.1"
                     /locus_tag="BV401_RS15185"
                     /protein_end="205"
                     /protein_start="26"
                     /score="91.0"
                     /tool="antismash"
                     /translation="LNIREVPAPQAGSGQIRVRVTAAGLNPMDWFMTSDADTATRFGLS
                     LPSGFGTDYAGVVDQVGHGVTEFAAGDRVFGGALSRAVADYVVIDVAGTIAAGGDAHHT
                     PDGVDDRTAATLAIAGCTAAAALAIVNPGPGDTLLIGGAGGGVGVFAVQLARLAGARVI
                     GTGSATSADALRALGA"
     CDS_motif       15137..15199
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BV401_RS15185_0001"
                     /evalue="6.60E-05"
                     /label="PKSI-ER_m5"
                     /locus_tag="BV401_RS15185"
                     /protein_end="181"
                     /protein_start="160"
                     /score="15.5"
                     /tool="antismash"
                     /translation="GDTLLIGGAGGGVGVFAVQLA"
     tRNA            complement(15793..15864)
                     /anticodon=(pos:complement(3805514..3805516),aa:Val,
                     seq:tac)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="BV401_RS15190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="BV401_15140"
                     /product="tRNA-Val"
     gene            complement(15793..15864)
                     /locus_tag="BV401_RS15190"
                     /old_locus_tag="BV401_15140"
     gene            16178..17488
                     /locus_tag="BV401_RS15195"
                     /old_locus_tag="BV401_15145"
     CDS             16178..17488
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019522502.1"
                     /locus_tag="BV401_RS15195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15145"
                     /product="hypothetical protein"
                     /protein_id="WP_087684202.1"
                     /transl_table=11
                     /translation="MLGLVLLPVPLLAVVGTLSFAGGSGGRRWFGGRGESQRAEAQAAK
                     DAAAAAFYELDTAQRDLRISIETITAVDDSPAARRTAADFSALGQRIDQVSRDYITAVD
                     AHDLDRDDLDGATASRARADLTRAKDALERTKADLDRFAQGLGPLLEQAETRLARLAPA
                     VERARQALLAASNALDAVRASGLRADDLAARLAGLSPELTKLNQGAGQHGVQETLRRAD
                     DVLRRAEAVRGEAERLPERAAEIDKRLVSLRTRAQAITTRAAGVEPVLSELRRRYSAAC
                     WQDLQPVPAQAARDVAQAEEKLKEAQAAREEQRWPDATALLATVRALLNSTDEAVSAAG
                     DRLRRLDEVSYDQQKEIERTRFAIRDAQRLAMAGRSTPDPRHARPLDDAVERLDRAIAG
                     LEGRHPDWWHFLSETEAVRQTVARVVQEIREERGGPH"
     gene            18102..18344
                     /locus_tag="BV401_RS15205"
                     /old_locus_tag="BV401_15150"
     CDS             18102..18344
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048498.1"
                     /locus_tag="BV401_RS15205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15150"
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="WP_079257459.1"
                     /transl_table=11
                     /translation="MPRYEYRCRACGTTFELSRPMAESSAPASCPDGHDDTVKLLSTVA
                     VTGAASSSSSSAASSARPPSGGGGGGGCCGGGCCG"
     gene            18567..>19121
                     /locus_tag="BV401_RS15210"
                     /old_locus_tag="BV401_15155"
                     /pseudo=""
     CDS             18567..>19121
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005478740.1"
                     /locus_tag="BV401_RS15210"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15155"
                     /product="DUF4383 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MATGRPSPIGPHPAGVARHWPERIGGHTTLDEHLPIDHRLSKFYR
                     VGAGLMGLVLVAFGILGLIDRVGFFDIGGATVAGLNTNGTLSVLSIAIGLLLFIGMLIG
                     GNFASTLNLVLGVLFLLSGFVNLALLETSFNFLAFRLQNVLFSFVVGLLLMWFGMYGRV
                     SGGLPHDNPYWRTRHPEQAERE"
     gene            complement(19615..20307)
                     /locus_tag="BV401_RS15215"
                     /old_locus_tag="BV401_15160"
     CDS             complement(19615..20307)
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Methyltransf_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060337.1"
                     /locus_tag="BV401_RS15215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15160"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_079260437.1"
                     /sec_met_domain="Methyltransf_3 (E-value: 3.2e-57,
                     bitscore: 192.0, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAESKSTPVTAELYDYVLRHNPPLDPVLRELVEVTHRNLPQQAGM
                     QSAEEQAPLLAFLVRLTGARHVVEVGTFTGFSALAMARALPADGRLIACDVSEEWTAYG
                     RKAWAKAGVEHRIDLRIAPALDTLRAMPAEPHIDLAYLDADKQNYIPYWEELVPRLNPG
                     GLIVADNVFYHGQVTEAAPPSAGAAIQAFNDHVAADARMEAVMLTVADGLTLARRLGRG
                     GGRGASEG"
     gene            <20568..>20702
                     /locus_tag="BV401_RS44695"
                     /pseudo=""
     CDS             20568..>20702
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004988711.1"
                     /locus_tag="BV401_RS44695"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="DedA family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGRPPPVRPADIGRTERRFGPHGTKAVSFGREVPVFRGVISVPAG
                     "
     gene            complement(20737..21597)
                     /locus_tag="BV401_RS15220"
                     /old_locus_tag="BV401_15165"
     CDS             complement(20737..21597)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060338.1"
                     /locus_tag="BV401_RS15220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_15165"
                     /product="HAD family hydrolase"
                     /protein_id="WP_079257460.1"
                     /transl_table=11
                     /translation="MSVLVASDLDRTLIYSAAALGLEMPDAEAPRLLCVETYEGRPLSY
                     MTETAAGLLAELVRTSVFVPTTTRTVEQYRRIRLPGPDPRFAICANGGQLLVNGEPDTD
                     WQQRVRTALADGCAPLEEVRAHLSATADPAWLLKERVAEDLFAYLVVERELLPGSYVKE
                     LTQWAEPRGWTVSLQGRKIYAVPKPLTKSAAVAEIKSRTGADEVLAAGDSLLDTDLLLA
                     ADRAWRPGHGELADVGWTAPQLTVVEETGVAAGEAIVRALGERSSVTWARARSQVIRAV
                     SRGRD"
ORIGIN
        1 acacctcggc cggatactcg ctggtgtgca ggaggttgag ctcgcccccg gggcccgagg
       61 tgtcccacac ccgcagcgtc ctgtcgtagc tgaggctgac cagcgaccgc gacgaggcgt
      121 tgtgcacgag gcgcttgatc cccgcctcgt gcgcgggggt ggcgttggcg gtcccgtcgg
      181 cgatgatgac gatctcgcca tcgtcgttgc ccgcgtacac ggtgccggtc ggggtgatgg
      241 cgatggtgtc ggtctccgcc ccgcccaggt cgacctcgga gacgagtccg ccggcatcga
      301 gcgaccagcg cttgacggtc ccgtcgtcgc tcgaggtcag cagttccctg ctgtcccccg
      361 cccaggcgac ggagatcacg tcggcggtgt gcccctcgaa ggaggccgtc agcctgccgg
      421 agaagtcgaa cacccgcacc ccgtggtcgc gggaggcggt ggcgaccagt tcgagggtgg
      481 ggtggaaggc cgacatctcc acgtcgtcct tgtggtcgcc gaggacggcg atgagcttga
      541 ggtcgggcac ggaccacagc cgtgccgtgt agtcgctcga cgaggtcacc agatggcgcc
      601 cgtccgggct gaaggccgcc tggttggcga ggtggtcgtg gtagacgcgg ctgatcgagg
      661 tgcgggttgc ggcgtcccag aggatgacct ggttgtcgta gcccgcggtg gcgatgaggt
      721 tcccaccgtg ggcggccacg ccgctgatgg gtccgagatg acggatcatg ctgactcctc
      781 gagccgaatg gtgtgcgcgg tgcgggcgac cttcgcggtc agataccccc tgttgtgggg
      841 gttggcgtac acgccggtgg acacggtgtg ccgcaccgcg atgccgtagt ggcgcagttg
      901 ttcgcgcttg tcggggttgt tggtgagcag gtcgatctcg acctcgccga gcgctcgcag
      961 catctgcgcg gccaccccgt agtcccgcag gtcgtcgtcg aggccgagcg cccggttggc
     1021 gctgaaggtg tccaggccct ggtcctggag gctgtaggcg tccagcttgt tgtacaggcc
     1081 gatcccgcgg ccctcctgcc gcaggtacag cagggtgcca ccggcggtat tgatcaggcg
     1141 catcgcctcc cgcagctgcg gcccgcagtc gcagcgcgcc gaaccgagca cctcaccggt
     1201 gaggcactcc gagtggaccc gtaccagggg cacttcgggg tgcctgggcc cgagccgcag
     1261 cgcgaggtgc tcgcgtccgt ccaggagccc gccgaaggtc atcacgtcgg ctgcgatggg
     1321 ttccgccgag ccgtggtgca gcgggatgcg caccttgcgg cggatccgtg cggcgggcag
     1381 cgcgccggtg tcgccgtcca gcaggctcac agacggctcg gcctcggcct gcggatgggc
     1441 gtcgtcgcgt ggctcgatca tggttcgttc gtcctccttg ccggttcttg cggcctcggc
     1501 acgggccgcc acgcggcacg cgtgagtcga aggtgcagca gcaccgtcgt agtggcgatc
     1561 ccgagcacca ggaaggtggg gggcgtgccc acgacatcgt caagtgcgga cacgaacacg
     1621 ggggacagca gagccgcacc gccggtcagc agccagatga gaccggaagc gcggcccagg
     1681 acaccgggcg ggaggtaccg gacgcgtgcc atgaccaccg tcgccatcac ggcgccctgt
     1741 cccagggccc cgagcacgac cgcgaacatg aagacaggcc atacgggcac gatcatcaga
     1801 atcagcgcga cggaccgcgc ggccacaccg agcgtcatcg gtgtccatgg ccgcagtcgg
     1861 cggcgctggg agaccagcag gttgccgacc aatgacgcca cgttcatccc cgcgatcgcg
     1921 aggccggcct gctggcccga aagggcccac ccatgccgca ggtggtaaac gatgagcgag
     1981 gtcagcccgg tgccgcacac cgcgctgagc accatgtccg ccacgagcat gacgctgatg
     2041 cgcttgtcct gcctgatggc gtcccagccg tcgcggatac gtgacggtgg cgcctcggcc
     2101 ccggcccgcg cctgagcccc ggccgcccgc cgcttcaccc accgcggtgc cgtacgccgg
     2161 ggcccgccgt cggtccggcc gcctttgtgc gagggcgcgg gggcggtttt gtgcggggac
     2221 gcgggggcgg agcgtgcggg cctgaccccc acggcccaga ccaccagcgg ggcgaagaac
     2281 gtgggcaggt tgagccacag cagcccttgg taccccaccc agggcagcag cgcggccacg
     2341 agcagcggac ccgccagagt ggtcgccagg aagaggctgt tgagcgtgcc tctggcccgt
     2401 acgggacagt cggggaactg ggcgggaacc ccagtcatcc agccggtgcg gtaggccagc
     2461 cccccggtct ccagcaccac cgcgcacagg aacagcagcc acggcgccga atgaccgccg
     2521 agcagcagca ggttcatggc gagcgccgcg ccggcctgcg ccagcaggcc ctggacgatc
     2581 aggccgcgca cgccccgccg gtccgcccac gccccgaggg cgggggcgaa caggtcgctc
     2641 acggggacgg cggcggccag ccaggccatc accaccaagg aatcggtgag ttggtaggcc
     2701 agcaggggca gggccgtggc gtacagggct tcgccgacgt tgttcgccgc gttgcccgcg
     2761 gcgaagacga ggaacctgcg gtcggcgagc gggttgggtt ccacggactc gtcggccgcg
     2821 tgcgcgcccg ctccgtccgg tgtcacggag cccgcttcct ccgcggtccc tgcgtcggtc
     2881 atcgtacggc ggcctcctca tcggcggcac cggcggcacc cgccgaaccg gtcgtacccg
     2941 ccgaaccggt cgtaccggcg gaggacaccg gccggtccga gagcggcagc cacaggtcgc
     3001 gcagcggagt gaggactcgg ccaccgcccg tgcgctccat cagatacagc cgcaggaatc
     3061 cgccgcggcc accgaccacg acataggcgc ggccgtccgg gccgtgcagt gcggccatgc
     3121 ccttgccgaa gtcgggcaag tcctcgtgga agtcgagcag ttcggcggtg tcgtagtcga
     3181 acgcggcgac ctgcatgccg tacgtgacga cgcagagcac cccgtcgatc aggacgcagt
     3241 tctcggcggt gttgtcgagc agttcggtga actggcgggt gggcttgtcc tcgcccacca
     3301 cgatctcctt gacgccgccg cccccggtga tccgcacccg gtccccgtcg gtgatgagcc
     3361 gcttggggta gctgttcagc tcggcgtacc aggatggttc ggcctggtcg ccgtaggcgg
     3421 tgagctgtcc gttgcgcgtg gccagcagcc gtcggccgtc gtccaggtag gcgcaggccc
     3481 acgcgctggc gggcaggtcc tcgacctgcc aggtcggctc gccggtcgcg gcgtcgaact
     3541 cgtatccgcc ggcgttgcag gcggccagca cccggccgcc gtccggcgac acggccacgg
     3601 tgtggatgat gccggggagc tgcgcctccc acaccgtggt gtccgcggtg gtgaaccggc
     3661 gcagtcgcga cggccagaac gcccccacca ggtcgtcgga ggcggcgcgg atccggcggg
     3721 agaaaccgag cccggtgcgg tggcggcccg tcacctcgag cgaggcgtgc cccgcgggcg
     3781 aggtgcgcat acgggcctcg aaggcaccgt cgtcggtggc cacgacgagc gccccgggct
     3841 ccgccgggtg cggctggatg tcccatacgc actggcgggg atggccgagc cgggtgagga
     3901 ccttgccctg cggggagagg gccgtcacct caccgtcctg ggtgagggtg tagatcctgc
     3961 cgtcctcgtc gaccgtgaca tcgatgatct gatggctgaa gccgcggata cgctgttcga
     4021 tcctcagtct cggcgtggag ttgtcgaaga cgaccagttc cccgtcgaag ccgccgatgt
     4081 aggcccggga gaagtcgggc gagaagacga gaccttccac gtcgttgcgc gcgatgtcca
     4141 tgcgctggtc gatctcgccg tccaggccca gggtgaccac gccgttgctg atgttgcgcg
     4201 tggggccgag ccccgcgtcg cagatggccc agtacctgtc gtggcgctcg tcgtagacca
     4261 cgcggtgcac attggaggtg tcgacctgca ccaccgttgg gaagtccagg tcgggcaggg
     4321 agccgagatg gatatggccg ctgcggtcgg agaccgcgtg cacaccgggc gcgtccgtgc
     4381 agaaccactc cagcatgtcg tagccgtgcg gccacaggga gatgcggtcg acggtgaacg
     4441 actcgacgtc caggacgacg acctggaagt acccgttgtt gaggtacgcc ttgccctgcc
     4501 acacgccgat gccgcgcagc atggtgggcg acggctgctc gccctccagc agatgttcgg
     4561 tgttggcggt ggacgccgca tcgagccgat cgctcagacg gagcgtctcg gtgtcccagc
     4621 ggcagatgtt gccggccttg tcccgggtga tgatccagtc gccgacgacc ttcaccgcgt
     4681 agacggggtc cccggagggg gcctgggcag tcgccgggag gggggacgag acgcggatgt
     4741 tgaggttgcg gtcgagccag tgcagcccac cccggacgtc acaggccaac agtccgtgtc
     4801 cgggttgact gacgatgcgg gtgatccgtt caagcgcgcc catgagaccg gactcctccc
     4861 tgtctggacg gctacgatgc gatgcgcccc cggggggagg tgacctcccc ccgggggcaa
     4921 gaccctcgac aaggtgcgtc agggctcagg gcgggtcaat cacgtggccg agcagcctgg
     4981 ctgtcggcga cgtgtcctgt tcccgcagta cgggtccggt ggaaccggat cccttcttca
     5041 gatggcggcg cgagtcacgc ggcggacgag cttggtcatc tgaattcacc tccttcgccg
     5101 aatcgagggg cgcttttgtg aacccacaca ccagggcttg atccgggtta cggatcgtca
     5161 cccacgaaca ttccgtgaaa acggatgggg cgggttgcac gcccggagcc caacggcgaa
     5221 acaaaacgcg ttgtgacgcc gcgaacttca ggcagggact agattgccca ccggggctac
     5281 cagtccgatt ccttatctgt accagttcca taccaccgct ctcaccagcg agttctccgc
     5341 gaatcacggc cgaaccccca tcaccctcga cgaatcccgg cacccttctc actgcatttg
     5401 cgacagagcg accgattccg ggtgaagtat gtttcccgtt ttatttacac ggccggtgtc
     5461 aacaatgagt gagtcggcgt tgcatgatgg agaggacccc tgctcgccgt actcccggaa
     5521 aaccaaggag agcagcatga ccaggatcgt tctcatttcg ggcagccttc gccacgactc
     5581 gctcaacact atggcgatcg cgaccatcga acgaatgctc accgctcgcc ccgaaccggc
     5641 ggcggccgta cggctcgcca tcgaggaact gccctactac caccagagcg atgacgagag
     5701 cggcaagcgg cacgaggccg tacatgccgc acgccacctg gtgacggcct ccgacgccgt
     5761 cctgatctcc acaccgtcct acaacggact ggtgtccggg gtgctgaaga acgcgctgga
     5821 ctggctctcc cggccctggg gggacagcgc cctgacggac aagccggtcg ccatgctcag
     5881 cgcgagtacg agtgcccgcg gcgcgatgga ggcccagtcg ggactgcgga cggtgctgga
     5941 gcgctcgggc gcggtgctca tcgccgcgcc acaggtcgcc ctcgcacgcg ccgacgcgat
     6001 cgccgccgag gacggccggt tcaccgaacc ggccaccgtc gcggccctgg aagcgctcgt
     6061 agaggcgctg ctcgcccacc tgagtccgga gccggcggcc atccatggca tatcgagcct
     6121 ttgagccgcg gtcagccggg tacgtccagg cgctgtgtgc cgatcaccga cagcagccgc
     6181 agagccccct ccgccgggga gccgggatcg gccgtgtaga tcacgactcg ctggtcccgg
     6241 tcggcgatgt ccaggacatc gcagttgagc gtgatgggac cgatcagggg gtgccgaaag
     6301 gtcttctgcg gggcgggctc gaccgacatg tcgtaggcgg cccacagccg ggcgaactcc
     6361 gcgctgccgg cgagcaggtc cttcaccagc gcggccactt cggggtcgtc ggggtagcgg
     6421 gcggcggcgg cccgcaggtg ccgggccgcg gtgcggccga agatctccat accggaccgg
     6481 ctgtaccact gccgctcccc cgccgaagaa tcgaggaagg tgcggcgcag gaagttgcgc
     6541 tcgtgccggg gcagggcgga gaagtcctcc aggagtgcgg ccgccaggtc gttgtgcgcg
     6601 atcacctcat aggccgcgga cagtacgagc gccgcggcgt gcggtaaccg ccgcagcagg
     6661 tccaggatgc tcgggcgcac ctcgcgggag ggccctggcg gcggggcggg cggggcaccg
     6721 gcgaggtagt gcagatgggc gcgctcggcg tccgagaggc gcagggcgcg ggtcagtccg
     6781 gccagcacct cgcgcgaggg gcgcgggccg cgggcctgct cgagccgcgt gtagtactcg
     6841 gtcgagatga acgccagctg cgccacctcc tcgcgccgca gccccggggt acggcgccgc
     6901 ggcccggcgg gcagccccac atcggcgggg gtgatccgct cgcgcctgct gcgcaggaaa
     6961 ccggccagct ctcgcctgtc catgtccccc agtgtcagcg ggccgacgaa gccgatccag
     7021 gtaccgccgg tgcctggatg cgggtatccg accggcccca ggctcatcgg catgaacacc
     7081 acccctacca cccacaccac ccacaccacc cacaccaccg acacctccgc ccccgccgcc
     7141 ccgggtctgc tggcgggcaa ggtcgccttc atcagcggag ccggccgcgg catcggcgcc
     7201 gccgcggcgc gcctcttcgc ccgggaaggc gcccgggtac tgctcgcggc ccgtaccgag
     7261 gaccagctca aagcggtgac cgaacagatc cgggcggcgg gcggcaccgc cgagtacgcg
     7321 gtgtgcgacc tggccgacgc gaccagcgtg cgcgccgccg tcgaccgcac ggtggaggcg
     7381 tacggccgac tcgacgccgc cttcaacaac ggcgcgatcg gcacgcggcg gcccggcccg
     7441 atggaccagg tgccggaggc ggacttcgac gagcagtacg gcgtcaacct caagggcgtc
     7501 tggctggccc tggccgccca ggtcgccgcg atcagggcga ccgccggcac gggcgccatc
     7561 gtcaacacct catccgtcgg cggctggaag ggcaaccccg tactgcccgc gtacagcgcg
     7621 atgaagcgag gtgtccacag cctcaccgag tcggccgccg tcgcctacgg cccggagggc
     7681 atccgcgtca acgccatcgc ccccggcacc acgctgaccg agatgatgcg ccactgggac
     7741 gcggagtcgc cgggcaccat cgaccaactc aacgcgcgca ccccgctgcg ccgcgcggcc
     7801 cagcccgagg aagtcgccga ggccgccgcc tggctactga gcgaccgcgc ctcctacatc
     7861 accggagtgg tcctctccgt cgacggcggc atgcgggcgt cgtgaaccga ggcgaggcgc
     7921 cgacgggccg atgttcctca ccggaaaatg aacgacggag ttcccctgct acggtgcgcc
     7981 gccgggctcg tgggggaaga gcgcctcgcc acgctcgaag ccgagtgcgc acgactggtc
     8041 gagctcggcg caggtgggag gacgccgcct cccgcgactc aacgtccggc tgacgtattg
     8101 ctgtcgtcgc gccactccgg cggctgggtg gcgatcaggt tgcggcgagg aactccacgg
     8161 cgcgctcatc cagatcagcc gcacagcgca caccgcgggc gcggaagcga gcgagcccac
     8221 tgcgcatccc cgtcacagcc ttgcgggtac ggacggaccg cacaccgtcc atgtggtcca
     8281 tcgccctgtt ccaggtggca cacgcctgct cgatgctgcc ccccttgagc tgcatctccg
     8341 cgctcgccac caggtcgagg gcgacgattc gcgcatagct tgccgggcgg gatgcggcgg
     8401 cccgcgcgta ctgctccgcc gcgttccttc gatcgcccaa cgtctcgtag accttcgcgt
     8461 tgcgcgagta gaccgacgcg gcaggcgggc cccaggcgag agcccagaac ggcatctcgt
     8521 ccccacagtc ggcggcgagg agagtacgcg cccgctcgac ctcaacgacg gccgcctgcc
     8581 tctgccggga cttggccagg gtgtgggcgt gcacgacacg gaaaagggat tcggtctgca
     8641 cgtccacctt gcccttggcg cggttcaacc cggtctcagc aagggcctgg cagtgctcgg
     8701 gccggtgcag cttgagccct tgcatggcca tcgtgcgcat cacgaaccca tcgtgcccgg
     8761 ggacaccgga ctcgacggcg agtgcgtagg actgaaggta atagcgctgg gccaggccct
     8821 gctgtcctgc gtcgtaggac ttccaaccga gcagatgcac accgcggccg gcggcggaga
     8881 gcatctgctg ccggatctcg tcggtgcgga agcggcctct gcacaggggg gcgacatcgt
     8941 cgcgcaggta ctgcaccagg gcgctgcgac cgtgctgtcc gccatggcgt tcgtccatct
     9001 cggagaagag ccggaccatg tcgcggacgg cagcgacttc ggccatgccg atggtctgac
     9061 cggctcgggc ggcggctgtg cggtcggcga tctctcggac gtacgacagg ggcaggccgg
     9121 cggcagcgac cgagtaggcg gaggtgctga ggaaacggcg ccggttcaat tcgtggctcc
     9181 acatcggtag cagggcgtcc agcggatcct cgccgaggga tagtccgagg ctgtcatccc
     9241 cttcctcatg cggcccgaga cccagatcgt gaagggtcag caggcgcccg agctggcggg
     9301 agagtgccac aacgagatag cggccggtat cgcctgcggg cacgacaccg ctgatccaat
     9361 gctcgatggt ggacttgttg gtccgtaacg ccgccccaca ctcggcggct acggcgcgca
     9421 cctccttggc cagggcctcg tacgtcagcc cggactcggc gaccaggttc ctcagctggt
     9481 gattcggcgt gcacttggtc atgagtacct gccccgtata cccgatatac cgctttgcct
     9541 gcccgacacc gtaccgccga agccgcaacc tgagttgact ggttgtcagg gccaggcggc
     9601 cggggacatt acggctttcc gaccccggcc gcgtggccag gtacgacgtc cacagcgcgc
     9661 ccattcccgg gcgcgaggga cggaacacca taaaggcagg aatcatgaac acgcagaccg
     9721 ccgctcccgt gtacaccgct ccggtcgtcc tggacgccgg tgacgtcgtc aaggtgacgc
     9781 tgggcacgaa caacttcgac accgccgacg acacccagta caagaacgcc tgatccatcg
     9841 gctgcctggg gccgggcgga tgtgcgccgc agtccggccc ccggcggact tgaacgggcg
     9901 ccggggcttc gaaagggccg tgttggggca cggccgccag cagcccggcg cccgttccgt
     9961 ttcgaccacc aagaacgaga gcgacgagag cgggctgctg atgcggtgga gcacaggatg
    10021 gtacggagcg agccgacacg atcggctacc gaggagcaga aagcccgtac cgggcctggc
    10081 cgcggcatgg accgtgggct gggccaccgg ccaagtacga tcggcaggct ccggcccgct
    10141 ggcactggcg gtcatcggtg actgcggcgc cgacgaccag cagctgcacc aggcactgac
    10201 aaccgtgcgg gcaagaaact gggcggcgct gacccgctgg cccggctcgt atctgacgat
    10261 cgcacgcagc ggcgaatccc tggcggtaat cggtgacctg gcctgccaac actgcgtgta
    10321 tttgcggagt gaaggaacag gaacgtggtg gtcgacgtca gccggagcgc tggccgccct
    10381 ggacggggcg ccgttcgatc cgaccgctct cgccgctcac ctggctctgg cacagccgga
    10441 tgtcttaggg catcgaagcc tgttccgcgc ggtgagccgc gtgccgaccg gacacctgtt
    10501 gctgatcact cccgatgggg cgaacactat tcgctacgag ccggtcgact accagccgat
    10561 cagcctccca gacgccgcgc cacgggtacg tgcagccctg agcgaagcgg tcgacacgcg
    10621 cttggacggc atgcgagcgg tgagcgcgga cctggccggg ctggactcca caacgctggc
    10681 atgcctcgct gcccggcgcg ggcccgtcac cgcagtgacc ttcgccgatg cccggctgag
    10741 agatgacgac ctctcctacg cggtgcgcac cgctgccgcg gtgccagaac tcacccacca
    10801 cgcagtgccc ggccgcgccg agaccgtgta ttacagcggc ttggacgacc tgtcctcact
    10861 accgctgact gacacgccca acgcctatgc ggtcacggcc ggcatcaagc gggccgtatt
    10921 gggggcggtg gccgaacgcc ggtcggcgac cgtgcacttc accggagctg ccggagacgc
    10981 cgtactgtcc gcgccctcct cctacctgtc cgatctgctt cgagaccgcc ggtaccgacg
    11041 ggctgtcgcg catgcccacg cccacgcccg gctgcggcac gtctccccac tgagcgtgct
    11101 gcgccgcgcc cgcccggcct cacgcgtcgg cctggccggc gcctggctac aggctgccac
    11161 cgaactgcgc gacactcccc gcgcatggat gccgcaggca gaacgccccg tcgcctgggc
    11221 gcctctgctc gccaccgctg actggatgag ccgcgaggtg cgccaccagc ttgccgaggc
    11281 cctcgacatc gctgccggtg agctgctgga ggaaccccgg cagctggcgg cgtggacgga
    11341 ccggcaagac ctggcacggc tgggagcgga tacggccggt ttgcgtgaac tcgcccgcgc
    11401 tgaccacgct acggagatcg ccgctccttt tctggacaac gaagtcatcc gggcctgcct
    11461 tgctgttccc gccgatcagc gtggcgcacc tggccggtac aagccgctgc tgggcgaagc
    11521 attcgcccgc accggtctgc taccggactt cgtcctgtcc cgtgcgacca agggtggctt
    11581 caacgcgctc gcctacgcag gactcaccca acacgcggcg gtcctctccc agctgctcgg
    11641 gccctcctcc cgcctctctg ccgccggact gatcagccag cctcccgtgg aacgcatgct
    11701 gcggcgcgcc gcggccgggc agcccaccgc ccagggcgcc ctgcaccttg ccgtcagcgc
    11761 cgagatctgg ctgcggcaga tggagaccac gaacgccgcc tcatggtggg aggtggttgg
    11821 ccatgtggca gctgcgtgaa ggcgcccatg cggtactcgc cgacgaaggc ggtgcaatcc
    11881 tcgacgagcg caccggccac tggacccttc ttgcccccac agcagccgcc gcggtcatga
    11941 tcttgctggc caccaccacc gaggaccagg ccgccggaca gtacgccacc cgctacggca
    12001 tcgacgccgc tcgggcaacc gccgatgtcc gcaccgtcgc tcacgtcctc atggcgcggg
    12061 gactcgccat caccgagcac gcacaccatc gccgccggtg ggggtggctg cgatgacgag
    12121 catggaggcg tactccaccg cccgggccgg taccttccct gaacgatgcg ccgcggccgc
    12181 gggcctcgcg cttgctctgg tgctgctgcg gctgcccttc cgcttcaccg tccgcgcggt
    12241 ccgtctggcg cgtcgggtcg gctgccgacg gccgactgcc acgcaggccg atgtcctgat
    12301 cacggcggtc aggcacgtcg gccgcttgtg gccggggcgg gccgcatgca tggagacatc
    12361 gctcggcgcg gtcctggccg ccgcgctact tggccgccga ctcaactggt gcctgggcgt
    12421 gcggttctcc ccgccgccgg tcgaatacca cgcctgggcc gagctgcccg accacgggcc
    12481 gatcggcgag tacaccgagg tgggctggca ccaccacacc gccctgacga tctgatcccg
    12541 acacagggcc gctgggcgtg tcctgcaccc gtccagagcg gttatcgcaa acgagtgccc
    12601 cacctcctcg aaggagtgaa cagtgaccac catcgccgac atcgctgaaa ccgtccccga
    12661 acgccactac acccaccacg aaggccgcgg cgccaccccg caccgctcca acccggtcgt
    12721 catccaccgc gagctgacca cactcgacgt ccctccaggc acgaacgtcg ccgaattcgg
    12781 caccgggtcc ggctactccg gcgccctact cgcacaactc gtcgggccca ccggccaggt
    12841 gaccagcctc gacatcgacc actacctgac ccgctgggcc aacctcatcc accacgatcg
    12901 gggcctgcgc aacgtccgct gctacaccgc cgacggcacg gccggcttcc ccagccgggc
    12961 cccgttcgac agggtggtgg cgtggtgcac gccaccacta ctgcctgagg catgggtgag
    13021 ccaaatggtc gacggcgggc tcgtggtggc tccgctgccg attgcggctg tgcccaacat
    13081 gacggtcgtt gccaggatcc gggtccgtaa cggccagccg gacgttgagg cgatcttcac
    13141 gggcggatac atcgaggcga ccgcctcgcc gaagggggat ctcgatctgc cgggacggtg
    13201 ggtggactgg gagaaccgtg tacccgcgcc atcctggatc tctgtcggtt ggcgcgacaa
    13261 ggacaattgg cggaacagcg gtgcccgcgc cacgctggat cggctggtga aagacgcgca
    13321 catcgagccg tacgacggac ctgaagtgga ctggccatcc tggcgtactt tcgtcgcggc
    13381 caagggcaac ccgtacgtga ccatggctgg tctgagcccg gatctgtggg cactggggca
    13441 ctcgacgccg accacggcag ctgtgattca gcaggacggc atgatcgttg ccgactgctc
    13501 cgactccccg tcgctggcag tgctgcgcgg ctggctatcc gaatgggaag cggccggccg
    13561 cccagccccc gacgtccaca ccccgatcct ggtccggcgc gacaacgggc aaggcccaag
    13621 tggctgggac ctgcgactca tcgacccctc cgggacgtgc agcttgcgca ggtaggcgtt
    13681 ggagagtggc gggcacttgt ggcgtcggcc ggtggcgggg tcgacgcggc cggcgaccgt
    13741 gatcttccct ctgggatggc gctgaccccg ttggagcgaa tgctgccgcg ctggcagcgc
    13801 gtggactggg tgttcgccat ggctggggaa cccattcatg gttaatgcga tgactacggt
    13861 ggtgtctgct cgacccgcca tgaccgactt ggcgtgcgtc tccgggtcgg cgcatgtgaa
    13921 cgtctcggag acgaggggca ggcggacacg cactcgtagc cggaacgccg tagatgagcg
    13981 gctcagggtg taggtcggag gccgtccatc agaatattca gcagccgacc tgccctggcc
    14041 tcgtgctcgg gtgagggggc cacagtgaag atgccgatga ggctggcggc gatgtcttcg
    14101 gcggtgacat cggcacgcag ctcgcccgtg gcgcggccgg cgtcgaggat gtcgtcgatg
    14161 gccgcgagca gttcggtctg ggtccgggca tgggcgatct cgcccgattc gatcatcgcg
    14221 agcagcgtgt cgagcatgcc gttcttcgtc gcgatccatt cgccgaacag gtccatccag
    14281 cgtcgcagcg ccgcgggcgg ggacagctga gcgagtagtt cgcgggcacc ggcggtgagc
    14341 cgcgcgacct gatcgcgata gaccgcgtca accagggact cgcggttggg gaagtgccgg
    14401 tagagcgtgg cgatgccgac cccggcttca cgtgcgaccg cacgcatgga cggctcggtg
    14461 tcggcggaca cgaacatgcg ggttgccact gcgaggagtt ggttgcggtt gcgagtcgca
    14521 tccgctcgaa gttcgcgagt ctgcaactct tccaaaacgg atcacgctcc gattgcgcta
    14581 gggtgtcgct tgtaaacgga gcatagtcca ctttcctttc gctcctctcg ttcgtccctg
    14641 agggaaacaa gtgagcatgc aagaaccgag cgtcaacacg tcggcgacca ccagcagggc
    14701 ggtccggctc gagtcattcg gcggtcctga ggtcctgaac atccgcgaag tacccgcgcc
    14761 gcaggccggc tcggggcaga tccgcgtgcg agtcaccgcg gctggcctga acccgatgga
    14821 ctggttcatg acctctgacg cggacaccgc cacccgcttc ggcttgagcc tgccgtccgg
    14881 gttcggaacc gactatgccg gggtcgtgga ccaggtcggt cacggcgtga ccgagttcgc
    14941 ggccggcgac cgagtgttcg gcggcgccct ctcccgcgcg gtcgccgact acgtagtcat
    15001 cgacgtggca gggaccattg cggcgggcgg cgacgcacac cacacccccg acggcgtcga
    15061 cgaccgcacc gccgccaccc ttgccatagc ggggtgcacg gccgccgccg ccctcgccat
    15121 cgtcaacccc ggcccgggcg acacgctgct catcggcggc gcgggaggcg gggtcggcgt
    15181 gttcgccgtc cagctcgctc ggctcgcggg cgcccgagtg atcgggacgg gatcggcgac
    15241 atcggccgat gccctgcgcg ccctcggggc cgagccggtc gcctatggcg acggcctggc
    15301 cgaccggctc cgcgccctgg cccccaccgg cgtcaccgcg gccatcgacc tcttcgggac
    15361 ggacacggtg cgggcggcac gagaccttgg cgttccggac gagcgcatca ccaccatcgc
    15421 cgcacaggtc gacgggatca caccggcaaa cggcgccaac gccgcccccg gcgccataga
    15481 ggagattgcc cgcctggtcg cggcgggccg gctccgtgtg cccattgcgg cgagcttccc
    15541 ggtggagcgg atccgcgcgg cggtcgaact gcaagccggc cgacatgtgc acggcaaggt
    15601 cgttatcgac ctccagccgt actgaccatg gacgttaggc gcggcgcgtc gtgcgccgag
    15661 ctcgtcgagg acgaggtgac cgaacaatgc accgatctct acgccgagcg cgcgggcgat
    15721 cagcctgaga ctgcccccca actcagccga gttggggggc agctaccgcc tctttcctac
    15781 gctcaatcac tgtgggcgca gacgggttcg aaccgccgac atctgccttg taagggcagc
    15841 gctctaccgc tgagctatgc gccccagggg agctgtcagc ctacagggtt cccggggcgg
    15901 ggccgcaatc gtgcggtcgg tggggagggg cctgggacgg ggcgggtttg gggtcggggt
    15961 cgggggtcgg gttcgggtgg gagaagtccg cagatcgcga accgaaccga gcactgtgtt
    16021 cgtcagtgtc gggtgggaga atgacattcg gacctgggcg atccatcggg agcgggtagt
    16081 ggcggcgaca tctggacact ctgcgcgtcc atcgcgccgt ccgcaccgtc cactccgtcc
    16141 ggccggcgac cgcgcgcgcc gtgcgcggcg tccctccgtg ctcgggctgg tgctgctgcc
    16201 ggtcccgttg ttggcggtgg tggggacgtt gtcgttcgcc ggtgggagcg gggggcggcg
    16261 atggttcggg gggcgggggg agagtcagcg ggcggaggcg caggcggcga aggacgccgc
    16321 ggcggcggcg ttctatgagc tggacaccgc gcagcgggat ctgcggatct ccatcgagac
    16381 gatcaccgcc gtggacgatt cgcccgccgc gcgccggaca gctgccgact tctcggcgct
    16441 ggggcagcgg atcgaccagg tcagccggga ctacatcacg gcggtggacg cccatgatct
    16501 ggaccgcgac gatctggacg gggccacggc ctcccgcgcc cgcgccgatc tgaccagggc
    16561 gaaggacgcg ctggagcgca ccaaggcgga tctggaccgg ttcgcgcagg ggctggggcc
    16621 gctgctcgag caggccgaga cgcggctggc gcggctggcg ccggcggtgg agcgggcccg
    16681 gcaggcgctg ctcgcggcca gtaacgcgct ggacgcggtg cgtgcctcgg ggctgcgggc
    16741 ggacgatctg gccgcccggc tggcggggct gtcgcccgag ctgaccaagc tcaaccaggg
    16801 ggccgggcag cacggtgtgc aggagaccct gcggcgcgcc gacgatgtgc tgcgcagggc
    16861 ggaggcggtg cgcggggagg ccgagcggct gccggagcgg gcggcggaga tcgacaagcg
    16921 gctggtgtcg ctgcgcaccc gcgcccaggc gatcaccacc cgggccgccg gggtcgagcc
    16981 cgtcctcagc gagctgcgcc gccgctacag cgcggcctgc tggcaggatc tccagccggt
    17041 ccccgcgcag gccgcgcggg atgtggcaca ggccgaggag aagctcaagg aggcgcaggc
    17101 ggcgcgcgag gagcagcgct ggccggacgc caccgcgctg ctggccaccg tacgggcgct
    17161 gctcaacagc acggacgagg ccgtttcggc cgccggggac cggctgcggc ggctggacga
    17221 ggtgtcgtac gaccagcaga aggagatcga gcgcacccgg ttcgcgatcc gcgacgcgca
    17281 gcggctggcc atggccgggc gcagcacccc cgatccgcgc cacgcgcgcc cgctggacga
    17341 cgccgtggag cgcctggacc gggccatcgc ggggctcgag gggcggcatc cggactggtg
    17401 gcacttcctc tccgagaccg aggccgtgcg gcagaccgtc gcccgggtcg tccaggagat
    17461 ccgggaggag cggggcgggc cgcattgagc cccccagcgc cctttagccc ggccgcgttg
    17521 ggcccccacc gcgttgagcc ccggccacat tgggcctcgc cgcgctgagc ccccaccgcg
    17581 ttgagccggg ccgcgttggg cccccaccgc gttgggcccc ggccacattg ggcctcgccg
    17641 cgctgagccc ccaccgcctt tagcccggcc gcgttgcccc gaccgcattg agcccccacc
    17701 gcgttcagcc cccggccgca ttgagccccc gccacgttga gcccggccgc atcgggcccc
    17761 cgccgccttt agctcggccg cgttgagccc cggccacgtt aggcccggcc gcattgcccc
    17821 ggccacgttg aacccggccg cattgacccc cgccgcgttg ggcccccgcc acattgcccc
    17881 ggccacattg cccccaccgc attgggcccc cggcgcgttg gcccgcccgc gttgggcccg
    17941 gccgcgttgg gccccaccga gttgggcccc cgaagctccg ggccccgagg ctccgggccc
    18001 cgagtccctc ggccctcagt tcctcagccc cctccgaggg ccgcagggct caggggggct
    18061 gtccgggggt tgagccgcgt tttggtggtt atcctcctgc catgcctcgc tatgagtacc
    18121 gctgccgcgc ctgcggaacc acctttgagc tgagtcggcc catggccgag tcctccgctc
    18181 ccgcgtcctg cccggacggg cacgacgaca cggtgaagct gctgtccacc gtggccgtca
    18241 ccggcgccgc gtcctcgtcc tcttcctccg ccgcctcctc cgcccggccc ccgtccggcg
    18301 gcggtggcgg tggcggctgc tgcgggggcg gctgctgcgg ctgaggccgg gccgggatgg
    18361 ggccgggatc gggccgaggt tgagcctcgg ggggcgcggg cggatgctgg gaggtacgta
    18421 cccgtgccgc gcccccggac gtacgcgacg ccgccggatg tgcgcgtgta cctcgtgtac
    18481 gcgacggtga cgtggccacc gcgggtacgg cctcgaccgc gaagagcgcg aagccgaggt
    18541 ccggcgccag cagaaggagg ccggagatgg ctacgggccg cccctccccc atcggtcccc
    18601 accccgccgg agtcgcacgg cactggcctg agcggatcgg cgggcacacc accctcgatg
    18661 agcacctgcc gatcgatcac cggctcagca agttctatcg cgtcggcgcc gggctcatgg
    18721 ggctggtgct cgtcgccttc ggcatcctgg gcctgatcga ccgggtcggc ttcttcgaca
    18781 tcggcggtgc cacggtcgcc ggactgaaca ccaacggcac gctgagcgtg ctctccatcg
    18841 ccatcgggct gctgctcttc atcggcatgc tcatcggcgg caacttcgcc tccacgctca
    18901 acctcgtgct cggggtgctc ttcctgctga gcgggttcgt caatctggca ctgctggaga
    18961 cctcgttcaa cttcctggcg ttccggttgc agaacgtgct gttcagcttt gtggtggggc
    19021 tgttgctgat gtggttcggg atgtacggac gggtcagcgg cgggctaccg catgacaatc
    19081 cgtactggcg gacccgccac cccgagcagg ccgagcgcga ggccgcccac gcgcgtgagc
    19141 tgatcgccgc gcgtgagttc gccgccgaac aggccggtgc ggccgtcccg cccggcaccc
    19201 cgctcacacc gggcgccccg ctcatgcccg gcgccgcgac cgcgccgggc gcgcccggcg
    19261 cacctggcgc cccgggcacc ccgcgtgggc ccggggagga gcccggcgaa cggcccgctc
    19321 ggccgcccgg taagtggggc gagctggacc ggcccggcgg cgccgagcac gccgcacagc
    19381 cgccccccgc cgaacggacc gagccggccg aagaggccag gcgggccgaa cgaaccgaac
    19441 ccgccgaacg aaacgagtcg gccgaacgga ccgaacccgc cccacgggcc gaacccgtcg
    19501 gcgggcccgg gaagccccat cgctggacgc gggcggcccc ccggcgctgg gcccgggtct
    19561 ggcggcgcgt ccgtccacgg cggctcagcc cccgacgcct ccgcgcccgg cggctcagcc
    19621 ctcggaggct ccgcgcccgc cgccacggcc gagccgacgc gcgagcgtca ggccgtcggc
    19681 gacggtgagc atgaccgcct ccatccgggc gtccgccgcc acatggtcgt tgaacgcctg
    19741 gatcgcggcg cccgcggacg gcggcgccgc ctccgtgacc tgcccgtggt agaacacgtt
    19801 gtccgcgacg atcagaccgc cggggttcag ccgcgggacc agctcctccc agtacgggat
    19861 gtagttctgc ttgtccgcgt cgaggtaggc gagatcgata tggggctcgg cgggcatcgc
    19921 gcgcagggtg tcgagcgcgg gcgcgatccg caggtcgata cggtgctcga cgcccgcctt
    19981 ggcccacgcc ttccgcccgt acgccgtcca ctcctccgac acatcgcagg cgatcagccg
    20041 gccgtcggcg ggcagcgccc gggccatggc cagcgcggag aagccggtga aggtgccgac
    20101 ctcgaccaca tggcgggcgc cggtcagccg gaccaggaag gccagcagcg gggcctgctc
    20161 ctcggcggac tgcattccgg cctgctgggg gaggttgcgg tgggtgacct cgacgagctc
    20221 gcgcaggacg gggtcgagcg gcggattgtg ccgcaggacg tagtcgtaca gctcggccgt
    20281 caccggtgtg ctcttgctct cggccatcgc ggcctcctct tcggctcctc ggctccccga
    20341 cccctcgcgt tcagcttccc agatggcgcg gaacggcgag cacccggcgg ccgcaacccg
    20401 ggttccccgg agttcgagct tctcgaagat ggcgttgatg tgcttctcga cggcggtcgc
    20461 gggactgatg tgcttctcga cagcgccgcg ggacacagtg cgaccgccgc cgccggaccg
    20521 gcgccgtccg gtcggatcac cggccgggcc accggcctgg tggacgcgcc ggacggccgc
    20581 cgccggtccg gcccgccgat atcggccgga ccgagcgccg cttcgggccg cacggcacca
    20641 aggcggtctc cttcgggcgc gaggtgccgg tcttccgcgg cgtgatctcg gttccggccg
    20701 gtatgggcgc ggccgtcccg ctcgggggtg atgtggtcag tcccggccgc gggagacggc
    20761 gcggatgacc tggctgcggg cacgggccca ggtgacggag gagcgctcgc ccagggcgcg
    20821 gacgatggcc tcgccggccg cgacgcccgt ctcctcgacc acggtcagct ggggtgccgt
    20881 ccagccgacg tcggccagtt cgccgtggcc agggcgccag gcgcggtcgg cggcgagcag
    20941 cagatcggtg tcgagcagcg aatcgcccgc ggcgagcacc tcgtccgccc cggtgcggct
    21001 cttgatctcg gcgacggccg cgctcttggt gaggggcttg ggcacggcgt agatcttgcg
    21061 gccttgcagg gagaccgtcc agccgcgcgg ctcggcccac tgggtgagct ccttgacgta
    21121 gctcccgggc agcagctccc gttcgaccac gagataggcg aacaggtcct cggccactcg
    21181 ctccttgagc agccaggcgg ggtcggcggt ggcgctgagg tgggcgcgca cctcctccag
    21241 gggcgcgcat ccgtcggcga gcgcggtgcg cacccgctgc tgccagtcgg tgtcgggctc
    21301 gccgttgacc agcagttggc cgccgttggc gcagatcgcg aagcgggggt cggggccggg
    21361 gaggcggatg cggcggtact gctcgacggt gcgggtggtc gtggggacga agacggaggt
    21421 gcggaccagt tcggcgagca gaccggcggc ggtctccgtc atgtacgaaa gcggccggcc
    21481 ctcgtacgtc tcgacgcaca gcagccgcgg ggcctcggcg tccggcattt cgaggccgag
    21541 cgcggccgcc gagtagatca gggtgcggtc gaggtcgctt gccaccagaa cgctcatcgt
    21601 gccgccaccg ttctctcgtc tctgccggcg atgtccgcgg tgttcgcctt acctgtggtg
    21661 ctgtctgccg tgctcgcctt accggtgctg tctgccgtgt tcgcctcacc ggtgatgtct
    21721 gccatgttcg ccttactggt cgctgtgtgc gccgtgccgg ccgccttacc gtcggctccg
    21781 gtggcacccc gggtgtagcg cgggtggatc agcccgacgc aggtgtacgg aagcccgtcg
    21841 atctcctcga ccggcactcc gcgctgctcg gcgagcagcc gcacatggtc caggtccgcg
    21901 cccgcgccgc gctgggcgag gatcttccat gggacgcggc gcagcagcac ccgggtggtc
    21961 tcgccgacgc ccggcttgac gaggttgacg tcgtggatgc cgtactcctg gctgatccgc
    22021 tcgaccgccg cccacccctc ccaggtgggg gtgcggtcgg tggccgcgag ccgcccggcg
    22081 tcggccgcgg ccgcctcggc gacctcggtg aagcgggccg agacggtgtc caggaagtgc
    22141 ccggagacat cggaaccggc cagttcgcgg tagtacttcg cgccgtggaa gtcgttcggc
    22201 ccgacgaggt cggcgcgcag cacggtgcgc gatatcagcc cggagacggt cgagttgagg
    22261 catgcggagg ggacgaggaa gtcgtcccgg gtgccgtagg tgtccacaca gcggccgggg
    22321 tcggcgagca ccgcgatccg cgggtcgaag tccgggtacg gggcgacggc gtccgacagc
    22381 tcgcgggtga tggcgccctt accggtccag ccgtcgacga agacgacgtc ggacgggtcg
    22441 tggtggtcgg ccagccagcg cagcgcggcg gtgtcgatac cgcggccgcg cacgatggag
    22501 atcgcgtagt gcgggaggtc gagaccgtgg gcatg
//
