LOCUS       NZ_CP019458            22000 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces autolyticus strain CGMCC0516 chromosome, complete
            genome.
ACCESSION   NZ_CP019458
VERSION     NZ_CP019458.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces autolyticus
  ORGANISM  Streptomyces autolyticus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10029028)
  AUTHORS   Yin,M., Jiang,M., Ren,Z., Dong,Y. and Lu,T.
  TITLE     The complete genome sequence of Streptomyces autolyticus CGMCC 0516,
            the producer of geldanamycin, autolytimycin, reblastatin and
            elaiophylin
  JOURNAL   J Biotechnol 252, 27-31 (2017)
   PUBMED   28472671
REFERENCE   2  (bases 1 to 10029028)
  AUTHORS   Yin,M., Jiang,M. and Lu,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2017) Yunnan University, Yunnan University, 2#
            Cuihu Beilu, Kunming, Yunnan 650091, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Analysis v. 2.3.0
            Genome Coverage                   :: 279x
            Sequencing Technology             :: Illumina; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 03:05:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,227
            CDSs (total)                      :: 8,141
            Genes (coding)                    :: 7,920
            CDSs (with protein)               :: 7,920
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 221
            CDSs (without protein)            :: 221
            Pseudo Genes (ambiguous residues) :: 0 of 221
            Pseudo Genes (frameshifted)       :: 74 of 221
            Pseudo Genes (incomplete)         :: 182 of 221
            Pseudo Genes (internal stop)      :: 9 of 221
            Pseudo Genes (multiple problems)  :: 42 of 221
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:31:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1967071
            Orig. end                         :: 1989071
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP019458.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22000
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="14"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22000
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22000
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12000](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12000
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(166..594)
                     /locus_tag="BV401_RS07530"
                     /old_locus_tag="BV401_07515"
     CDS             complement(166..594)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058761.1"
                     /locus_tag="BV401_RS07530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07515"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_069871363.1"
                     /transl_table=11
                     /translation="MKRQDLDDLVRLRRARDRMDRDYAEPLDVPALARGALMSPGHFSR
                     SFRAAFGETPYSYLMTRRIERAKALLRRGDLSVTEVCIAVGCTSLGSFSSRFTQLVGES
                     PSSYRARSHDHGAAIPACMAKIHTRPVRNGEARPAARP"
     gene            717..1127
                     /locus_tag="BV401_RS07535"
                     /old_locus_tag="BV401_07520"
     CDS             717..1127
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012894118.1"
                     /locus_tag="BV401_RS07535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07520"
                     /product="VOC family protein"
                     /protein_id="WP_069871536.1"
                     /transl_table=11
                     /translation="MDLTIHWTFLPHDDPDASLAFYRDTLGFEIRKDVGYDGMRWLTVG
                     PAGQPGTSIVLEPPALDPGITDDERRTIVEMMAKGSYARLTLATADLDGVFARVRSSGA
                     EVVQEPTEQPYGIRDCAFRDPAGNMIRINELR"
     gene            1251..3644
                     /locus_tag="BV401_RS07540"
                     /old_locus_tag="BV401_07525"
     CDS             1251..3644
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013000733.1"
                     /locus_tag="BV401_RS07540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07525"
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="WP_079256569.1"
                     /transl_table=11
                     /translation="MSMATETGTRSPAPHAADSHDLIQVHGARENNLKDVSIEIPKRRL
                     TVFTGVSGSGKSSLVFNTIAAESQRLINETYSTFVQGFMPTLARPEVDVLEGLTTAIIV
                     DQQRMGADPRSTVGTATDANAMLRILFSRLGEPHIGPPGAYSFNTASVSASGGFTVDRG
                     AEKTRTEKVSFSRTGGMCTHCEGRGTVSDIDLTQLYDDSKSLSEGPFTIPTYTGDGWVV
                     RVITESGFFDRDKPIREYTKRERHDFLHREPTKVKINGVNLTYEGLIPKLQKTFLAKDR
                     ESMQPHIRAFVDRAVTFARCPECDGTRLSEAARSSRIGKVSIADACAMEIRDLSEWIRG
                     LDEPSVAPLLAKLQHTMDSFVEIGLGYLSLDRASGTLSGGEAQRVKMIRHLGSSLTDAT
                     YVFDEPTTGLHPHDIQRMNNLLLRLRDKGNTVLVVEHKPETIAIADHVVDLGPGAGTAG
                     GAVCFEGTVEGLRNSDTVTGRHLDDRAVLKETVRKPTGTLEIRGATANNLRDVDVDVPL
                     GVLCVVTGVAGSGKSSLIHGSIPVPEGVVSVDQTPIRGSRRSNPATYTGLLDPIRKAFA
                     KANGVKPALFSANSEGACPTCNGAGVIYTDLAIMQSTATTCEECDGRRFDASVLEYHLG
                     GLDISEVLAMSVVEAEEFFGGGAARTPAAHRILQRMADVGLGYLRLGQPLTTLSGGERQ
                     RLKLAVHMADKGGVYILDEPTTGLHLADVQQLLGLLDRLVDSGKSVIVIEHHQAVMAHA
                     DWIIDLGPGAGHEGGEVVFEGTPADLAAARSTLTGEHLAEYVGG"
     gene            complement(3698..4876)
                     /locus_tag="BV401_RS07545"
                     /old_locus_tag="BV401_07530"
     CDS             complement(3698..4876)
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069051.1"
                     /locus_tag="BV401_RS07545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07530"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_069871358.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 9.9e-27, bitscore:
                     92.7, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.4e-20, bitscore:
                     72.2, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 4.1e-31, bitscore:
                     107.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLEYTPDQRRLRDELRAYFAELVPDDAYARYADSTGQKRFYRAT
                     IRRLGSDGWLGVGWPEEYGGRGLGPVEQFIFFDEAAQAGVPLPLMALNTVGPTIMRFGT
                     EEQKGYFLPKVLSGEIDFAIGYSEPDAGTDLASLKTRAVRDGDDYIINGQKTWTTNGDT
                     ADWVWLAVRTDPEAKPHKGISILLVPTDDPGYSATLIRTLASHDTTASYYENIRVPATR
                     RVGAENEGWRMITTQLNYERVTLAAHGTMAIRALRGVRQWAADTKLPDGRRVIDLGWVR
                     GRLARTHARLDAMKLLNWQMVEALQRDALTPQDASAVKVYGSEARRDAYAWLMEIVGAA
                     GPLKEGSAGEVLHGELERGYRSSVVFTFGGGNNEVQREIISWIGLGMPRVRR"
     misc_feature    complement(4988..5001)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            complement(5013..7121)
                     /locus_tag="BV401_RS07550"
                     /old_locus_tag="BV401_07535"
     CDS             complement(5013..7121)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058770.1"
                     /locus_tag="BV401_RS07550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07535"
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_069871356.1"
                     /transl_table=11
                     /translation="MENTAAPAAAVLPPRPQPRQPRRYRRPAPWLGLVAIGYAVVQLAM
                     VIPHTGHALGWDESVYVSQVDPRTPPAYFSAPRSRGVSLLVAPVVAATDSIPVLRVLLM
                     LLSAGALYGAFRVWARLLPPPQVALAALLFSGLWITQISGPAVMPNLWVAIGAVAAVGW
                     FLRAPDEPNARWWLAAVLAGVTLVRTPDGGWLALPLLIGAIGVRTWRPALPALIGGPLL
                     GAAQWIGEAYDRFGGIGGRLNVSSHVEGGMGLHFSVGAALRSLNGPQLCRPCEVPLRHP
                     ELTVWWLALPVLTLLAVHAALRDRQELRRVRVGLGRPAARPPAVPLTLLPIVCAAALAL
                     PYLLLIDYSAPRFLMPSYALLALPIAGLVFRAVRAARSPQHLAVALGVIVTLHLASQFV
                     ILDHTAKQSDTTTGRYRTAAQGLQRLGLRPPCLVTGDRALPIAYHAGCSSAQTSGNNRS
                     TTLPSLLRRAAREPTALLLRRGQARPPSYARTWVGYPLPGTEWNAYLPPDQARESEAAK
                     SRQETSGNGASMGAMTTTYPTTSWAGFEAAEPTFAGYAQDRFRRYRHHVLATLRQDGSP
                     RVTPLEVTFLSGELWLGMMPDSRKALDLRRDPRFSVQANPGPGDGLTEGDVRVSGRAVE
                     VTDPEAVARFAEAVRPPEPFHLFRTEVTEVVHTASENGEMVLRTWRPGRPVQVVRRGSD
                     DSPPRVEG"
     misc_feature    7263..7278
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.75"
                     /tool="antismash"
     gene            7264..8256
                     /gene="dhaK"
                     /locus_tag="BV401_RS07555"
                     /old_locus_tag="BV401_07540"
     CDS             7264..8256
                     /EC_number="2.7.1.121"
                     /GO_function="GO:0004371 - glycerone kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006071 - glycerol metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="dhaK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058771.1"
                     /locus_tag="BV401_RS07555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07540"
                     /product="dihydroxyacetone kinase subunit DhaK"
                     /protein_id="WP_069871354.1"
                     /transl_table=11
                     /translation="MKMLINVPETVVADALRGLAACHPELTVDIENRVIVRRDAPVEGK
                     VALISGGGSGHEPLHGGFVGPGMLDAACPGEVFTSPVPDQMVRAAAAVDSGKGVLFIVK
                     NYTGDVLNFDMAAELAEDEGIQVAKVLVNDDAAVTDSLYTAGRRGTGATLFVEKIAGAA
                     AEEGAPLERVESIARRVNEVSRSFGVALSACSTPAKGGPTFDLPAGELELGVGIHGEPG
                     RERRAMMTSREIADYAVEVVVEDLRPDNPVLLLVNGMGATPQLELYGFAAEVHRALGER
                     QVAVARTLVGNYVTSLDMAGASITLCQVDEDLLRLWDAPVRTAGLRWGA"
     misc_feature    complement(7265..7279)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 20.24"
                     /tool="antismash"
     misc_feature    complement(7266..7281)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.07"
                     /tool="antismash"
     misc_feature    7269..7284
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.07"
                     /tool="antismash"
     gene            8346..8951
                     /gene="dhaL"
                     /locus_tag="BV401_RS07560"
                     /old_locus_tag="BV401_07545"
     CDS             8346..8951
                     /EC_number="2.7.1.121"
                     /GO_function="GO:0004371 - glycerone kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006071 - glycerol metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="dhaL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058772.1"
                     /locus_tag="BV401_RS07560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07545"
                     /product="dihydroxyacetone kinase subunit DhaL"
                     /protein_id="WP_069871533.1"
                     /transl_table=11
                     /translation="MLDTPFFLRWLTAAAASVSREAARLTDLDSAIGDADHGTNMQRGF
                     AAVAEALEKEPPGSPGATLILAGRQLISKVGGASGPLYGTLLRRAGKALGDAERITPQQ
                     LADALRAGVDAVAQLGGAAPGDKTMLDALLPAVEALGAGAGSFAAAGEAAEKGALATVP
                     MLARKGRASYLGERSVGHQDPGATSSALLIAALAEAAR"
     gene            8948..9364
                     /gene="dhaM"
                     /locus_tag="BV401_RS07565"
                     /old_locus_tag="BV401_07550"
     CDS             8948..9364
                     /EC_number="2.7.1.121"
                     /GO_function="GO:0047324 - phosphoenolpyruvate-glycerone
                     phosphotransferase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="dhaM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019526857.1"
                     /locus_tag="BV401_RS07565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07550"
                     /product="dihydroxyacetone kinase phosphoryl donor subunit
                     DhaM"
                     /protein_id="WP_069871352.1"
                     /transl_table=11
                     /translation="MTDEGEKKLVGIVLVSHSAAVADSVAEMAKGLSGGGTAPVRAAGG
                     TEDGGFGTSPELIAEAAHAVDRGAGVAVLVDLGSAVLAVKALLAEGDELPEGTRLVDAP
                     LVEGAVAALVTASTGADVEAVLQAASEAYDYRKV"
     misc_feature    9911..9924
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.48"
                     /tool="antismash"
     misc_feature    9912..9925
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.56"
                     /tool="antismash"
     gene            10001..11080
                     /locus_tag="BV401_RS07570"
                     /old_locus_tag="BV401_07555"
     CDS             10001..11080
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058774.1"
                     /locus_tag="BV401_RS07570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07555"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_079256570.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 8.3e-52, bitscore:
                     174.9, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPTLSPGRLDADTVRESVDVVLEDFLAAKARTTPQHHLPYLSG
                     LLRDFLSGGKRIRPLLCVTGWQAVGNGEDTEAVFRVAACLEMFHAFALIHDDVMDDSDT
                     RRGRPTIHRTLAALCAADRRPDQIERFGVGGAVLLGDLALTWSDELLHSAGLPPAQFNA
                     VLPLLSEMRTEVMLGQYLDLQATGELTDDIEATLTVIRYKTAKYTIERPLHVGAAIAGA
                     GPDTMEAISAYALPLGEAFQLRDDLLGVYGDPESTGKSQLDDLRAGKNTTLIALALRGS
                     DSVQAARLRSLIGNPLLDERDAATVQEIFAATTAREAVEQMIDDRRTQALRALDDAPFT
                     ADAVHALKQIARMATVRNS"
     gene            11077..12000
                     /locus_tag="BV401_RS07575"
                     /old_locus_tag="BV401_07560"
     CDS             11077..12000
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058775.1"
                     /locus_tag="BV401_RS07575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07560"
                     /product="terpene synthase family protein"
                     /protein_id="WP_069871348.1"
                     /sec_met_domain="T1TS (E-value: 8.5e-16, bitscore: 57.2,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTGPSTAGAQDISRTSVRPYLEECTRRFQEMFDRYVVTRPTKVE
                     LTDAELREVIDDCNAAVAPLGKSVSDERWISYVGVVLWSQSPRHIKDMEAFKAVCVLNC
                     VTFVWDDMDPALHDFDLFLPQLRKICEKYYGPEDAEVAYEAARAFVTSDHMFRDSPIKA
                     ALCTTSPEQYFRFRVTDIGVDFWMKMSYPIYRHPEFTEHAKTSLAARMTTRGLTIVNDF
                     YSYDREVSLGQITNCFRLCDVSDETAFKEFFQARLDDMIEDIECIKAFDQLTQDVFLDL
                     IYGNFVWTTSNKRYKTAINDVNSRIR"
     gene            12015..13376
                     /locus_tag="BV401_RS07580"
                     /old_locus_tag="BV401_07565"
     CDS             12015..13376
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000061: Hydroxylation (95% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058776.1"
                     /locus_tag="BV401_RS07580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07565"
                     /product="cytochrome P450"
                     /protein_id="WP_079256571.1"
                     /sec_met_domain="p450 (E-value: 2.3e-83, bitscore: 279.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPAKSSAQPERSWTTGTAPGSVPLLGHTLALWRQPLQFLASLPA
                     HGDLVEVRLGPSRAYLVCHPELVRHVLLNPRTFDKGGVFDKARQLLGNSLSVSRGEEHR
                     SQRRMIQPAFHTPKISAYTAAVADDTRAAIGSWEPGRTLDISDTMHALLMRVAARTLFS
                     TGIDEATIDEARHCLRTVSDGIYKRTMAPLGIMEKLPTPGNRRYDRANARLRQIVDEMI
                     RDRRRSGTDHGDLLSTLLRAEHPETGKGLDDGEVLDQVVTFLVAGSETTASTLAFVFHL
                     LGAHPEVEKRVHAEIDEVLEGRVATFEDLPSLEYTRGVITESLRLYPPSWMAMRVTAAE
                     TELGGRTIPAGTMILYSAQALHHNPELFPDPERFDPERWLPGRAEEVPRGALLPFGAGS
                     HKCIGDVLALTETALIVATIASRWRLRPVPGTTLRPEPKATLEPGPLPMVCEPR"
     gene            13460..14821
                     /locus_tag="BV401_RS07585"
                     /old_locus_tag="BV401_07570"
     CDS             13460..14821
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000062: Hydroxylation (94% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058777.1"
                     /locus_tag="BV401_RS07585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07570"
                     /product="cytochrome P450"
                     /protein_id="WP_079260323.1"
                     /sec_met_domain="p450 (E-value: 1.5e-79, bitscore: 266.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTAQHPATRHWRHALAPGGLPLAGHALLMGRKPLQFLASLPAHG
                     DLVELRLGPRPVFLPCHPELVQQVLVNARIYDTGGPVKEKAKPILGNGLITSDWADHRR
                     QRRLVQPAFQAARIAKYAEVMEEECAAESTAWSARRPIDVSHEMLALTARVTARALFST
                     DMAPHAVAEIQHCLPIVVEGAYRQAIDPTGLLARLPLAANRRFDDALRRLNQLIDRMID
                     DYKAADDGDRGDVLSALFAAQDDETGGTMSDQEIHDQVMTLLLAGIETTASALTWTWFL
                     LGRNPRAEAALHAEVDEVLGGRAPVYADVPRLAHTQRVFSEALRLFPPAWLFTRTTTEA
                     TELGGRRLPPGSDVLISPYVMHRDPALFPDPESFDPDRWLPERAKDVARNSYLPFGGGS
                     RKCIGDVFGMTEATLALAAIAGRWRMRPIPGTKIRPRPQMSLTAGPLRMIPEPR"
     gene            complement(15016..16209)
                     /locus_tag="BV401_RS07590"
                     /old_locus_tag="BV401_07575"
     CDS             complement(15016..16209)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008741294.1"
                     /locus_tag="BV401_RS07590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07575"
                     /product="cytochrome P450"
                     /protein_id="WP_069871343.1"
                     /sec_met_domain="p450 (E-value: 2.9e-16, bitscore: 58.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQDLSALGADFVVNPYPVYARLRERGPVHRVRTDTSGVFWLVVG
                     HEEARAALTDPRLSNDVRHSAAWQDDGGNAIGRNMVQTDPPHHTRLRGLVARTFTPGRI
                     EALRPRVQRIADELLDAMVPLGRADLVEDYALPLPLAVICELLGVPETDRKAFHDWYLE
                     STDLTCPETAGAAAQALTGYFAELIESKRRAPGDELLSALVRTMEGDGDALSAEEMLGM
                     TFVLLVAGYETSANLISSGTLALLRHPGQLAALRADWSLLEGAIEEMLRYDGPVESAAF
                     RFTREPVEIAGTAIAAGEPVAVALAAGSRDPRRFAEPDRFDIRRSSRGHLAFGHGVHHC
                     LGAPLARLEGAVAFRALLERCPDLALDGDPAELAWRPSLMLRGLRRLPVRFSTAPDA"
     gene            16333..17013
                     /locus_tag="BV401_RS07595"
                     /old_locus_tag="BV401_07580"
     CDS             16333..17013
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058778.1"
                     /locus_tag="BV401_RS07595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07580"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_069871341.1"
                     /transl_table=11
                     /translation="MGSRVEKETPLRRDARRNREMLITAAREIYTDQGVDAPLDDIARR
                     AGVGSATLYRRFAGRAELIEAVFGDSLRDILRAAEEARSAVDAWVGLTAYLERIFGLLA
                     ADRGTNDLMTTGIQGVPSLDALREENAKTLDVLLRRAQEQGAVRKDATAEDLQFMLAAL
                     GRAVPGSTVAAPLAWRRYLFLLLDGLRPEGSHPLPAPSLTTEQLNAAMLQLGKVRRPRA
                     GRAD"
     gene            17285..18712
                     /locus_tag="BV401_RS07600"
                     /old_locus_tag="BV401_07585"
     CDS             17285..18712
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1074: major
                     facilitator family transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058779.1"
                     /locus_tag="BV401_RS07600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07585"
                     /product="MFS transporter"
                     /protein_id="WP_079256572.1"
                     /transl_table=11
                     /translation="MPTPDSPASAPPTPPGSLRRIVAASLIGTTIEWYDFFLYGSAAAL
                     VFNKLFFPDSDPLVGTLLSFLTYAVGFAARPVGALVFGHYGDRLGRKKLLILSLLMMGG
                     ATCAIGLLPTHATVGSAAPVLLTALRLLQGFALGGEWGGAVLLVSEHGDARRRGFWASW
                     PQTGAPAGQLLATGVLSALTALLSDSAFESWGWRVPFLLSGVLVVVGLWIRLSVDESPV
                     FKAALARAEARKAATDGGADAAEKMPLVAVLRHHWRDVLIAMGARMAENISYYVITAFV
                     LVYATSDHVGLGKQTALNAVLIASAVHFAVIPAWGALSDRIGRRPVYLLGAAGVGAWAF
                     PFFLLIDTKGFPALLLAVTVGLIFHGAMYAPQAAFFSEMFATRMRYSGASIGAQFSSVA
                     AGAPAPLIATALLADYGSATPIALYVIAAALLTLVAVGVAKETRDRDLAAVEPTSAPSP
                     RPASEGAGRKARSASAQ"
     gene            complement(18706..20820)
                     /locus_tag="BV401_RS07605"
                     /old_locus_tag="BV401_07590"
     CDS             complement(18706..20820)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058780.1"
                     /locus_tag="BV401_RS07605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07590"
                     /product="GAF domain-containing protein"
                     /protein_id="WP_079256573.1"
                     /transl_table=11
                     /translation="MPVTMPDDRPEAPYLELLVRGAPAEAYERPVLRARADKAPAELLA
                     ALERAKLLALRVRGELEGRRRREAELSALFETAHDLAGLRDLDAVLQAIVQRARSLLGT
                     EVAYLTLNDPTAGDTYMRVTDGSVSARFQQLRLGMGEGLGGLVAQTARPYVTENYFDDP
                     RFQHTHAIDAGVRDEGLVAILGVPLLLGSGVIGVLFAADRRARVFEREQIALLGSFAAH
                     AAVAIDTAHLLAETRTALAELEAANEIIRDRSRVIERASDVHDRLTELVLRGGGVHDVA
                     DALAEVLSGSVEFLETDEAPAAAVDRSRADGHAVRDGEEDWVAAVSAGGELLGALVLRG
                     HPRLDPMDQRTLERAAMVTSLLQLARRSAGEAEQRVRGELLDDLLDAPDREPRLLRERA
                     ARLRADLDTPHVVLAAGIEAPDTGTPAAGPCGAPGGGPGTTPGGGPGTAPASGPGGARA
                     SGPGGASGSRPGGAPGAGPGGGPGGAPAEDAAGRRRLWSAASHLAATRHGLAAARDGGT
                     VLLLPLAEGDTADALARRTARQLGTAVHAAVTVGASAPVPAPAARPGDVAAGYAEARRC
                     LAALRVLDRAGQGAAAEDFGFLGLLLAGTREGAPAGTGVQDFVHRTVGAVIDYDERRGT
                     ELIRTLDAYFAGGMSPARTKDALHVHVNTVAQRLERIGRLLGPDWQSPARSLEIQLALR
                     LHRLASAVGY"
     misc_feature    20984..20998
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.07"
                     /tool="antismash"
     gene            complement(21090..21896)
                     /locus_tag="BV401_RS07610"
                     /old_locus_tag="BV401_07595"
     CDS             complement(21090..21896)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058781.1"
                     /locus_tag="BV401_RS07610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07595"
                     /product="3-hydroxybutyrate dehydrogenase"
                     /protein_id="WP_079256574.1"
                     /sec_met_domain="adh_short (E-value: 3.2e-29, bitscore:
                     101.1, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSASTTPGPGPRPSDGPDLSCRTALVTGAAGGIGRACTLRLATAG
                     ARVRAVDLDAEGLTDLVDAAAGLPGQVEAHPLDLTDLDAAERAAAGIDILVNNAGLQLV
                     RPIEDFPPEVFSRVLTVMLEAPFRLVRGALPHMYARGWGRIVNISSVHGLRASPYKSAY
                     VAAKHGLEGLSKVAALEGAAHGVTSNCVNPGYVRTPLVERQIADQAEAHGISPERVVSD
                     VMLADSAVKRLVEPEEVAEAVAYLCGPHTSFVTGASLSMDGGWTAH"
ORIGIN
        1 acatccggct gcgagggcga cccgacggtc acccagcgca tcccctcgaa cccgacgtca
       61 ttgcggacct cgaggccgag cacatcgcgg tagaagggga tcgccttgtc gtggtcgtcg
      121 acggcgatga aacattggga gagcgtgatg tccatgccgc tcacgctacg gccgggcggc
      181 gggacgcgct tctccgttcc tgaccggccg cgtgtggatc ttggccatgc acgccgggat
      241 ggcggcgcca tggtcatggc tccgggcccg gtagctgctc gggctctcgc cgaccagctg
      301 tgtgaagcgc gagctgaacg accccagcga ggtgcagccc accgcgatgc agacttcggt
      361 caccgagagg tcgccgcgcc gcagcagcgc cttggcccgc tcgatgcggc gggtcatgag
      421 gtagctgtac ggcgtctcgc cgaaggcggc gcggaagctg cgggagaaat ggccgggcga
      481 catcagggcg ccccgcgcca gcgccgggac atcgagcggc tcggcgtagt cgcggtccat
      541 ccggtcgcgg gcccgccgca gccggacgag gtcatcgaga tcctgccgtt tcacccgctc
      601 agcttcgcac agcgcccagg ggcgcggacg aggggctgcg actgggagcg agaggcgacc
      661 ggaccggtca ggaatggaga agccccggtc agaagggcgc ggctagcgtg accgccatgg
      721 acctcaccat tcactggacc ttccttccgc atgacgaccc ggacgcctcc ctggccttct
      781 accgcgacac cctcggcttc gagatccgta aggacgtcgg gtacgacgga atgcgctggc
      841 tcacggtcgg ccccgccggc cagcccggaa cctctatcgt cctggagcct ccggccctcg
      901 accccggcat caccgacgac gagcgccgca ccatcgtgga gatgatggcc aagggcagct
      961 acgcccgtct caccctggcc accgccgacc tcgacggcgt cttcgcccga gtgcggagca
     1021 gcggcgccga ggtcgtccag gaaccgaccg agcagccgta cgggattcgc gactgcgcct
     1081 tccgcgaccc cgcgggcaac atgatccgca tcaacgagct gcgctgagcc ctccggcgac
     1141 ggcggccacg acccgcgaac cggacgtatt gttcgaagcc gaccaggtcg agccaggcga
     1201 caccggtggg gaccgcgaag acggtcccca cccgaacaga tggagacacg atgagcatgg
     1261 ccacggagac gggcacgcgg tcgcctgcgc cccacgccgc cgacagccac gatctgatcc
     1321 aggtgcacgg cgcgcgcgag aacaacctca aggacgtcag catcgagatc ccgaagcgcc
     1381 ggctgacggt gttcacgggc gtctcgggct cgggcaagag ctcgctggtg ttcaacacga
     1441 tcgccgcgga gtcacagcgg ctgatcaacg agacctacag cacctttgtg cagggcttca
     1501 tgccgacgct ggcgcggccc gaggtcgatg tgctcgaggg gctgaccacc gcgatcatcg
     1561 tggaccagca gcggatgggt gccgatcccc gctccacggt cggcaccgcc accgacgcca
     1621 acgcgatgct gcgcatcctc ttcagccggc tcggcgagcc gcatatcggc ccgcccggcg
     1681 cgtactcctt caacaccgcc tcggtctccg cgagcggtgg gttcacggtc gaccgcggcg
     1741 ccgagaagac caggaccgag aaggtgtcct tcagccgcac cggtggcatg tgcacgcact
     1801 gcgagggccg gggcacggtc tccgacatcg acctcaccca gctctacgac gactccaagt
     1861 cgctctccga gggtccgttc accatcccca cctacaccgg ggacggctgg gtcgtgcggg
     1921 tcatcaccga gtcgggcttc ttcgacaggg acaagccgat ccgtgagtac accaagaggg
     1981 agcggcacga cttcctccac cgcgagccca ccaaggtgaa gatcaacggc gtcaacctca
     2041 cctatgaggg gctgatcccg aagctccaga agaccttcct cgccaaggac cgcgagtcga
     2101 tgcagccgca tatccgggcg ttcgtggacc gggcggtcac cttcgcccgg tgtcccgaat
     2161 gcgacggcac ccggctgagc gaggcggccc ggtcctcccg gatcggcaag gtcagcatcg
     2221 ccgacgcctg cgcgatggag atccgcgacc tgagcgaatg gatccgtggg ctggacgagc
     2281 cgtcggtggc gccgctgctc gccaagctcc agcacaccat ggactcgttc gtggagatcg
     2341 gcctcggcta cctctcgctc gaccgggcct ccggcacgct ctccggcggc gaggcgcagc
     2401 gcgtcaagat gatccgccac ctgggctcct cgctcaccga cgccacctac gtcttcgacg
     2461 agcccaccac gggtctgcac ccccatgaca tccagcggat gaacaacctg ctgctgcggc
     2521 tgcgggacaa ggggaacacg gtgctcgtgg tggagcacaa gccggagacg atcgccatcg
     2581 ccgaccatgt ggtggacctc ggaccgggcg ccggtacggc gggcggcgcc gtctgtttcg
     2641 aggggaccgt cgaggggctg cgcaacagcg acaccgtcac cggccgccac ctggacgacc
     2701 gggcagtgct caaggagacg gtgcgcaagc ccaccggcac gctggagatc cgcggcgcga
     2761 cggcgaacaa cctgcgcgat gtcgacgtgg acgtcccgct cggcgtgctc tgtgtggtca
     2821 ccggcgtcgc cggctccggc aagagctcgc tcatccacgg ttccatcccg gtcccggaag
     2881 gtgtggtctc ggtggaccag accccgatcc gcggttcgcg gcggagcaac ccggccacgt
     2941 acaccgggct gctcgacccg atccgcaagg cgttcgccaa ggccaacggc gtcaaaccgg
     3001 cgctgttcag cgccaactcc gagggcgcct gccccacctg caacggcgcc ggcgtcatct
     3061 acaccgacct ggcgatcatg cagagcaccg ccaccacctg tgaggagtgc gacggcaggc
     3121 gattcgacgc gtcggtgctc gagtaccacc tcggcggcct tgacatcagc gaggtgctcg
     3181 cgatgtcggt ggtcgaggcc gaggagttct tcggcggcgg cgcggcgcgc acaccggccg
     3241 cccacaggat cctccagcgg atggcggacg tcggcctcgg ctatctccgc ctcggccagc
     3301 cgctcaccac gctgtccggc ggtgagcggc agcggctcaa gctggccgtg cacatggccg
     3361 acaagggcgg tgtctacatc ctcgacgagc cgaccaccgg gctgcacctc gccgacgtgc
     3421 agcagctgct cgggctgctc gaccggctgg tcgactccgg caagtcggtc atcgtcatcg
     3481 agcaccacca ggccgtcatg gcacacgccg actggatcat cgacctcggc cccggcgcgg
     3541 gccacgaggg cggcgaggtc gtcttcgagg gcacacccgc cgacctcgcc gccgcccgct
     3601 ccaccctcac cggcgagcac ctggcggagt acgtcggcgg ctgaccggag gcgtcggcgg
     3661 ccgaccgggg cgtcgcggga agcgccgtcg cggcggctca gcggcgcacc cgtggcatcc
     3721 ccaggccgat ccaggagatg atctcccgct ggacctcgtt gttgccgccg ccgaaggtga
     3781 agacgacgct gctgcggtag ccgcgctcca gctcaccgtg gaggacctcg cccgccgagc
     3841 cctccttcag cggtccggcg gcgccgacga tctccatcag ccaggcgtag gcgtcgcggc
     3901 gcgcctccga gccgtacacc ttgacggcgg aggcgtcctg cggggtgagg gcgtcgcgct
     3961 ggagggcctc caccatctgc cagttgagca gcttcatggc gtccagcctg gcgtgcgtac
     4021 gggccagccg gccgcgcacc cagcccaggt cgatcacccg gcggccgtcg gggagcttgg
     4081 tgtcggcggc ccactggcgg acgccgcgca gggcgcggat ggccatggtg ccgtgggcgg
     4141 cgagggtgac ccgttcgtag ttgagctggg tggtgatcat gcgccagccc tcgttctcgg
     4201 cgccgacgcg gcgggtggcc gggacgcgga tgttctcgta gtagctggcg gtggtgtcgt
     4261 gcgaggcgag ggtcctgatg agggtggcgg agtagccggg gtcgtcggtc gggacgagca
     4321 ggatgctgat gcccttgtgg ggtttggcct ccgggtcggt gcggaccgcg agccagaccc
     4381 agtcggcggt gtcgccgttg gtcgtccagg tcttctgacc gttgatgatg tagtcgtcgc
     4441 cgtcgcgcac cgcgcgggtc ttgagcgagg cgaggtcggt accggcgtcg ggctcgctgt
     4501 agccgatggc gaagtcgatc tcaccggaga ggaccttggg gaggaagtac cccttctgct
     4561 cctcggtgcc gaaccgcatg atcgtgggcc cgaccgtgtt gagcgccatc agcggcagcg
     4621 gcaccccggc ctgggccgcc tcgtcgaaga agatgaactg ctcgaccggg ccgagcccgc
     4681 gcccgccgta ctcctctggc cagcccaccc ccagccagcc gtccgagccg agccggcgga
     4741 tggtcgcgcg gtagaaccgc ttctgcccgg tggaatcggc gtagcgggcg taggcgtcgt
     4801 cggggaccag ctcggcgaag tacgcgcgca gctcatcgcg caaccgccgc tgatcagggg
     4861 tgtattcgag gtccacggcc cctcctggag tctcgcgtgc gccgtgacgg cgggctggga
     4921 gcgtcctggg atcgaggggc acggtagaac gtgttccaac aatacggaag ggccgtggac
     4981 cgggcccgtc gacccggtcc acggcgcggg cctcagccct ccacccgggg cgggctgtcg
     5041 tcggagccgc gccgcaccac ctgtaccggc cgaccggggc gccaggtccg cagcaccatc
     5101 tccccgttct ccgaggccgt gtgcaccacc tcggtcacct cggtgcggaa gaggtggaag
     5161 ggctcgggcg gccggaccgc ctcggcgaag cgggcgaccg cctcggggtc ggtcacctcg
     5221 accgcccggc cgctcacccg tacgtctccc tcggtcagcc cgtcccccgg gccggggttg
     5281 gcctgcaccg agaaccgcgg atcgcggcgc agatccagcg ccttgcgcga gtccggcatc
     5341 atgcccagcc acaactcacc ggagaggaag gtcacttcga gcggggtcac ccgcggggag
     5401 ccgtcctggc ggagggtggc gagcacatgg tggcggtagc gccggaagcg gtcctgggca
     5461 tagccggcga aggtgggctc ggccgcctcg aatccggccc agctggtggt cgggtaggtc
     5521 gtcgtcatgg cgcccatgct cgcgccgttt ccggacgtct cctgtcggga tttcgcggct
     5581 tccgactccc gcgcctggtc cgggggcaga tacgcgttcc actcggtgcc cggcagcgga
     5641 tagcccaccc aggtgcgggc gtaggacggg ggccgggcct ggccgcgccg cagcagcagc
     5701 gcggtgggtt cacgggcggc gcgccgcagc agcgagggca gggtggtgga ccggttgttc
     5761 ccgctggtct gggcggagga gcagcccgcg tggtacgcga tgggcagggc gcggtcgccg
     5821 gtcaccagac agggcggccg cagccccagc cgctgaagcc cctgcgcggc ggtgcggtag
     5881 cgcccggtgg tggtgtcgga ctgcttcgcg gtgtggtcga ggatgacgaa ctggctggcc
     5941 agatggagcg tgacgatcac cccgagggcc accgccagat gctgcggtga gcgcgcggcc
     6001 cgtacggcgc ggaacaccag cccggcgatc ggcagcgcca gcagggcgta ggagggcatc
     6061 aggaagcggg gtgcggagta gtcgatgagc agcagatagg gcagggcgag tgcggccgcg
     6121 cagacgatgg gcagcagggt cagcggcacg gcggggggcc gggcggccgg gcggccgagg
     6181 cccacccgca cccggcgcag ctcctggcgg tcgcgcaggg cggcgtgtac ggcgaggagg
     6241 gtcagcacgg gcagcgccag ccaccacacg gtcagctccg ggtggcgcag gggcacctcg
     6301 caggggcggc acagctgggg tccgttgagg ctgcgcagcg cggcgcccac gctgaagtgg
     6361 agccccatac ctccctcgac atggctggag acgttcagcc gccccccgat gccgccgaag
     6421 cggtcgtacg cctcgccgat ccactgggcg gcgccgagca gcggtccgcc gatcagcgcg
     6481 ggcagggcgg ggcgccaggt gcgcaccccg atggcgccga tcagcagcgg cagggcgagc
     6541 catcccccgt cgggggtgcg caccagggtg acgcccgcga ggacggcggc cagccaccag
     6601 cgggcgttgg gctcgtccgg tgcccggagg aaccagccga cggcggcgac ggcgccgatg
     6661 gccacccaga ggttgggcat caccgcggga ccgctgatct gggtgatcca cagcccggag
     6721 aagagcagtg cggccagggc gacctggggt gggggcagca gccgggccca gacccggaag
     6781 gcgccgtaga gcgcgcccgc ggacagcagc atgagcagga cgcgcagcac cggaatggag
     6841 tcggtcgcgg cgaccacggg cgcgaccagg agactgacgc cgcgcgagcg gggtgcgctg
     6901 aagtacgcgg gcggggtgcg cggatcgacc tgggagacgt acacggactc gtcccagccc
     6961 agcgcgtggc cggtgtgcgg gatcaccatg gcgagctgga ccacggcgta tccgatggcg
     7021 accaggccga gccagggggc cggtcgacgg taccgccgcg gctggcgggg ctgggggcgc
     7081 gggggcagca cggcggccgc cggtgcggca gtattctcca tgcgcgcacc atatgatgac
     7141 tatgtacctt tttcgtccta ttaggccatt cggctcagtg tccaaggggt gccattgacg
     7201 tgacggatcc gtaggctgtt gcagcggtgc acagccccca tccggcggag gacggacaca
     7261 cctatgaaaa tgctcatcaa cgtccccgag accgtggtcg ccgacgcgct gcgcggactg
     7321 gccgcctgcc accccgagct gaccgtcgac atcgagaacc gggtgatcgt ccggcgggac
     7381 gcgccggtcg agggcaaggt ggcgctgatc tccggtggcg ggtcgggaca cgaaccgctg
     7441 cacggcggtt tcgtggggcc cggcatgctc gacgccgcct gtcccggcga ggtgttcacc
     7501 tcccccgtac cggatcagat ggtgcgcgcg gcggccgcgg tggacagcgg caagggcgtg
     7561 ctgttcatcg tcaagaacta cacgggcgac gtgctcaact tcgacatggc cgccgagctc
     7621 gccgaggacg agggcatcca ggtcgccaag gtcctggtga acgatgacgc ggcggtcacc
     7681 gacagcctct acacggccgg ccggcgcggc accggcgcca ccctgttcgt ggagaagatc
     7741 gcgggcgcgg cggccgaaga gggcgcgccg ctggagcggg tggagtcgat cgcccggcgg
     7801 gtgaacgagg tctcgcggag cttcggcgtc gcgctcagcg cctgctccac cccggccaag
     7861 ggcggcccca ccttcgatct gcccgccggg gagctggagt tgggcgtggg catccacggc
     7921 gagccggggc gtgagcggcg ggcgatgatg acctcccgcg agatcgccga ctacgcggtg
     7981 gaggtggtgg tcgaggacct gcgcccggac aatccggtgc tgctgctggt caacggcatg
     8041 ggggcgaccc cgcagctgga gctgtacggc ttcgccgccg aggtgcaccg ggcgctcggc
     8101 gagcggcagg tggcggtggc gcgtacgctc gtcggcaact acgtcacatc actcgacatg
     8161 gcgggcgcct cgatcacgtt gtgccaggtc gacgaggacc tcctgcggct gtgggacgcg
     8221 cccgtgcgga ccgcagggct gcgctggggc gcctgaggcc gggcggccca cgatacgtac
     8281 gctgtcgccg ttggctactc cccgaggagg cgtctgtgtc cagcagtgaa cccgccgtcg
     8341 acgacgtgct cgacacccct ttcttcctcc gatggctcac cgccgcggcc gcgtccgtga
     8401 gccgtgaggc ggcccgtctc accgatctgg actccgcgat cggcgacgcc gaccacggca
     8461 ccaacatgca gcgcggcttc gccgccgtgg ccgaggcgct ggagaaggag cccccgggct
     8521 cgcccggggc cacgctcatc ctggccgggc gccagctgat ctccaaggtg ggcggggcct
     8581 ccggaccgct gtacggcacg ctgctgcggc gcgcgggcaa ggcgctcggc gacgccgagc
     8641 ggatcacccc gcagcagctg gcggacgcgc tgcgggccgg ggtggacgcg gtggcgcagc
     8701 tcggcggtgc cgcgcccggc gacaagacga tgctggacgc gctgctcccc gccgtcgagg
     8761 cgctgggcgc gggcgccggg tcgttcgcgg ccgcgggcga ggccgccgag aagggggcac
     8821 tggccaccgt gccgatgctg gcccgcaagg gccgggccag ctatctgggt gagcgcagcg
     8881 tcggccatca ggacccgggc gccacctcgt cggcgctgct catcgcggcg ctcgcggagg
     8941 cggcgcgatg accgacgagg gcgagaagaa gctggtcggc atagtcctgg tgtcgcacag
     9001 cgcggcggtg gccgactcgg tggccgagat ggcgaagggg ctgtccggcg gtggcaccgc
     9061 gccggtgcgc gccgcaggcg gcaccgagga cggcgggttc ggcaccagtc cggagctcat
     9121 agcggaggcg gcccacgcgg tcgaccgggg cgcgggagtg gcggtcctgg tggacctggg
     9181 cagcgcggtc ctggccgtca aggcgctgct ggccgagggc gacgaactgc ccgagggcac
     9241 ccggctggtg gacgcgccgc tcgtggaggg cgcggtcgcg gccctcgtca ccgcctccac
     9301 cggggcggat gtggaggcgg tgctccaggc ggcctcggag gcgtacgact accgcaaggt
     9361 gtgatagcga cgcgctattg aacgggcccc gccgagtgaa ggcgaggccc gttcagcttt
     9421 caacgaagtc accgcgcgca tattgcgcgg ccgcgtattt ccctgatact cggcgcgtac
     9481 ggggcgagtt gcccggtttc ggaccgcacc gggcacggcg acagcacccc ggacccccgc
     9541 ccgccaagtg ataggcgcga tagcagaacg ggcttccgaa tccgtcgatc ttgcgtctag
     9601 actgctcatg tccgagtggg gggaccggcg gcactcaggg ggaataagtg gacgtaattg
     9661 agtgtgcccg cgcgcacctg gcatccatcg aaacgatgat gtccacgcgg gtgccgcgcc
     9721 cgccgggacc ccattgccgc ccggcccgga ttccatgcgc ggaaatgacc cgaccgcgcc
     9781 tgccccatgg ctccctgagc gtctgaacta cgcgcgcccg tcgcggcgcg ttcggcactt
     9841 cggccatggg gcggcggtag cgccccgcgt ccgccttcat ggtgccgcac tcagcacgat
     9901 cggcaatcca tcttttccat acaaagcagg ggtttccgcg ttcctgtttt ttctcgttaa
     9961 tcaacggatt tcgacatttc gacgtggagg agtcagtcgc atgaccacac ccacgctcag
    10021 ccccggccgc ttggatgcgg ataccgtccg tgagtcggtg gacgtcgtac tcgaagactt
    10081 tctggcggcc aaggcccgca ccacaccgca acaccatctg ccgtatctct ccgggctgct
    10141 ccgggatttc ctgtccggcg gaaaacgcat acgccccctg ttgtgtgtca ccggctggca
    10201 ggccgtcggc aacggggagg acaccgaggc ggtgttccgg gtggccgcct gcctggagat
    10261 gttccacgcc ttcgcgctga tccacgacga cgtcatggac gacagcgaca cccgccgcgg
    10321 ccggccgacc atccatcgca ccctggccgc gctgtgcgcc gccgaccgca ggcccgatca
    10381 gatcgagcgg ttcggggtcg gcggggcggt gctgctcggc gacctcgcac tcacctggtc
    10441 ggacgagctc ctgcactcgg ccggcctccc ccccgcccag ttcaacgccg tactgccgct
    10501 gctgtcggag atgcgcaccg aggtgatgct gggccagtac ctcgatctcc aggccaccgg
    10561 ggagctgacc gacgacatcg aggccaccct caccgtcatc cggtacaaga ccgccaagta
    10621 caccatcgag cgtccgctgc acgtcggagc cgccatcgcg ggcgccggcc cggacaccat
    10681 ggaggcgatc agcgcctacg ccctgccgct gggcgaggcg ttccagctgc gcgatgatct
    10741 gctgggcgtg tacggcgatc cggagtcgac cggcaagtcc cagctggacg atctgcgagc
    10801 cgggaagaac accaccctga tcgcgctcgc cctgcgcggc tccgacagcg tccaggcggc
    10861 gcggctgcgc agcctcatcg gcaatccgct gctggacgag cgggacgccg cgaccgttca
    10921 ggagatcttc gccgccacca ccgcccggga ggccgtcgag cagatgatcg acgaccgccg
    10981 gacgcaggcc ctgcgggccc tcgacgacgc cccattcacc gcggacgcgg tccacgcgct
    11041 caagcagatc gcccgcatgg ccactgtgag gaactcatga cgaccggacc ttccacggcc
    11101 ggggcccagg acatcagccg gaccagcgtc cgcccgtacc tggaggagtg cacccgccgc
    11161 ttccaggaga tgttcgaccg ctatgtcgtc acccggccca ccaaggtcga attgaccgac
    11221 gccgaactgc gcgaggtcat agacgactgc aacgcggcgg tggcccccct cggcaaatcg
    11281 gtttccgatg agcgctggat ctcctatgtg ggggtggtgc tctggtccca gagcccccgc
    11341 catatcaagg acatggaggc gttcaaggcc gtctgcgtcc tgaactgcgt gaccttcgtg
    11401 tgggacgaca tggatcccgc gctgcacgac ttcgatctct tcctgcccca gctgcgcaag
    11461 atctgcgaga agtactacgg ccccgaggac gcggaggtcg cgtacgaggc ggcgcgcgcc
    11521 ttcgtcacca gcgatcacat gttccgcgac tcacccatca aggcggcgct gtgcaccacg
    11581 tccccggagc agtatttccg tttccgggtc acggacatcg gtgtcgactt ctggatgaag
    11641 atgtcgtatc cgatctaccg gcatccggag ttcaccgaac acgccaagac aagcctggcc
    11701 gcacggatga ccacccgcgg actcaccatc gtcaacgact tctactccta tgaccgcgag
    11761 gtctccctgg gacagatcac caactgtttc cggctctgcg atgtgagcga cgagacggcg
    11821 ttcaaggagt tcttccaggc ccgcctcgac gacatgatcg aggacatcga gtgcatcaag
    11881 gcgttcgacc agctgacgca ggacgtcttc ctcgatctga tctacggcaa cttcgtctgg
    11941 accaccagca acaagcgcta caagacggcc atcaacgacg tcaactcccg catccggtga
    12001 gggaacgggg aaccgtgact cccgcgaaga gctccgcaca gccggagcgc tcctggacca
    12061 ccggcacggc gcccggctcg gtgccgctgc tggggcacac cctggcgctc tggcgccaac
    12121 cgctccagtt cctggcctcc ctgcccgccc acggcgatct ggtggaggtc aggctggggc
    12181 ccagccgcgc ctatctggtc tgccatccgg agctggtgcg ccatgtgctg ctcaaccccc
    12241 gtacgttcga caagggcggg gtcttcgaca aggcgcggca gttgctcggg aacagcctct
    12301 cggtctcccg gggcgaggaa caccgctccc agcggcggat gatccagccc gcgttccaca
    12361 ccccgaagat ctccgcctac accgccgcgg tcgccgatga cacccgcgcc gcgatcggct
    12421 cctgggagcc ggggcggacc ctggacatca gcgacaccat gcacgccctg ctgatgcggg
    12481 tcgccgcgcg gaccctgttc tccaccggga tcgacgaggc gacgatcgac gaggcgcgcc
    12541 actgtctgcg caccgtctcg gacggcatct acaagcgcac catggcgccc ttggggatca
    12601 tggagaagct cccgacgccg ggcaaccggc gctacgaccg ggccaacgcc cggctgcggc
    12661 agatcgtgga cgagatgatc cgcgaccggc ggcgctccgg caccgaccac ggcgatctgc
    12721 tctccacgct gctgcgcgcc gaacaccccg agaccgggaa gggattggac gacggcgagg
    12781 tcctggacca ggtggtcacc ttcctggtcg ccgggagcga gaccaccgcc tccaccctcg
    12841 ccttcgtctt ccatctcctg ggcgcccacc cggaggtgga gaagcgggtg cacgccgaga
    12901 tcgacgaggt cctcgagggt cgcgtcgcca ccttcgagga cctgccgtcc ctggagtaca
    12961 cccgcggggt catcaccgag tcgctgcggc tgtacccgcc gtcctggatg gccatgcggg
    13021 tcacggcggc cgagaccgaa ctcggcggcc ggaccatccc ggcgggcacg atgatcctct
    13081 acagcgccca ggcgctgcac cacaaccccg aactgttccc cgaccccgag cggttcgacc
    13141 ccgagcgctg gctccccggc cgcgccgagg aggtgccgcg cggggcgctg ctcccgttcg
    13201 gcgcgggcag ccacaagtgc atcggggacg tcctggcgct gaccgagacc gccctcatcg
    13261 tggcgacgat cgcgagccgg tggcgtcttc gcccggtgcc cgggaccacc ttgcgccccg
    13321 agccgaaggc gacgctcgaa cccggcccgc tgcccatggt gtgcgagccg cgctgacacc
    13381 gtccggtccg gggggccgcc ccggaccgga cgccccgtac cttccgtacc ccacctcgcg
    13441 aatgaaggac atcttccgca tgaggaccgc gcagcacccg gcgacgcgcc actggcggca
    13501 cgccctcgcc cccggcgggc ttccactggc cggccatgcc ctgctcatgg gccgcaagcc
    13561 gcttcagttc ctggcctccc tgcccgccca cggcgatctg gtcgagctcc ggctggggcc
    13621 ccggcccgtc tttctgccct gtcatccgga gctggtccag caggtgctgg tgaacgcgcg
    13681 gatctacgac accggcggac cggtgaagga gaaggcgaag cccatcctgg gcaacggcct
    13741 gatcacctcc gactgggcgg accaccgccg gcagcgccgg ctggtgcagc ccgccttcca
    13801 ggccgcccgg atcgccaagt acgccgaggt gatggaggag gagtgcgcgg ccgagtcgac
    13861 ggcgtggtcg gcgcggcggc ccatcgacgt cagccatgag atgctcgcgc tcaccgcgcg
    13921 ggtgacggcc cgtgcgctct tctcgaccga tatggcgccg cacgccgtgg ccgagatcca
    13981 gcactgtctg cccatcgtcg tggagggcgc ctaccggcag gcgatcgacc ccaccgggct
    14041 gctggccagg cttccgctcg cggcgaaccg gcgcttcgac gacgcgctcc gccggctcaa
    14101 ccagctcatc gaccgcatga tcgacgacta caaggcggcg gacgacggcg accgcggcga
    14161 tgtgctctcc gccctcttcg ccgcacagga cgacgagacc ggcggcacga tgtcggacca
    14221 ggagatccac gatcaggtca tgaccctgct gctggccggg atcgagacca ccgcctccgc
    14281 gctgacctgg acctggttcc tgctcggccg caacccccgg gccgaggccg cgctgcacgc
    14341 cgaggtggac gaggtgctgg gcgggcgggc cccggtctac gccgacgtcc cccggctcgc
    14401 ccacacccag cgggtgttca gcgaggcgct gcggctcttc ccgcccgcgt ggctcttcac
    14461 ccggaccacc accgaggcca ccgagctcgg cgggcggcgg ctgccccccg ggtcggacgt
    14521 gctgatcagc ccgtatgtga tgcaccgcga tccggcgctg ttccccgacc cggagtcctt
    14581 cgaccccgac cgctggctcc ccgagcgggc caaggacgtg gcacggaact catatctgcc
    14641 gttcggcggc ggcagccgca agtgcatcgg cgacgtcttc ggcatgacgg aggcgacgct
    14701 cgccctggcc gcgatcgcgg gccgctggcg gatgcgcccg attccgggga cgaagatccg
    14761 gccgaggccg cagatgagcc tcaccgccgg tcccctgcgg atgattccgg aaccacgctg
    14821 accgccctgc cccacggacc gcggtggtcg gccaccgcgg tccgtcgagt ccgtcgggca
    14881 gccggggtcc gccgggctgc tggggtccat caggttgccg ggatccgtcg agctgccggg
    14941 gtccgccgga ccgccggggt ccgccgggcc tgcatggccg cggccggcca gggcgcacat
    15001 cccgtgggcg gggactcagg cgtccggggc ggtggagaaa cgtaccggca ggcgccgcag
    15061 gccgcgcagc atcaggctgg gccgccaggc gagttcggcc ggatcgccgt ccagggcgag
    15121 atcggggcag cgctccagca gggcccggaa ggcgacggcc ccttcgagac gggccagcgg
    15181 agcgcccagg cagtggtgca caccgtgccc aaaggcgaga tggccgcgcg acgagcgccg
    15241 gatgtcgaaa cggtccggct cggcgaagcg ccgggggtca cgcgacccgg cggccagggc
    15301 gaccgcgacc ggctccccgg ccgcgatggc cgtaccggcg atctccaccg gctcccgggt
    15361 gaagcggaac gcggcgctct ccaccgggcc gtcgtagcgc agcatctcct cgatcgcgcc
    15421 ctccagcagc gaccagtcgg cgcgcagcgc ggccagttgc ccggggtggc ggagcagggc
    15481 gagggtgccg ctggagatca ggttggcgga ggtctcgtag ccggcgacca gcagcacgaa
    15541 cgtcatgccg agcatctcct cggcggagag cgcgtcgccg tccccctcca tcgtgcggac
    15601 cagggcgctg agcagctcgt cgcccggggc cctacgcttg gactcgatga gctccgcgaa
    15661 gtagcccgtc agggcctggg cggcggcacc tgcggtctcc gggcaggtca ggtcggtgct
    15721 ctccagatac cagtcgtgga acgccttacg gtccgtctcc ggcaccccca gcagctcgca
    15781 gatgacggcc aggggcagcg gcagcgcgta gtcctcgacg agatccgcgc ggcccagcgg
    15841 gaccatggcg tccaggagtt cgtccgcgat ccgctggacg cgggggcgca gggcctcgat
    15901 ccgtcccggg gtgaacgtgc gggccaccag cccccgcagc cgggtgtggt gcggcgggtc
    15961 ggtctgcacc atgttccgtc cgatggcatt gccgccgtcg tcctgccacg cggccgagtg
    16021 acgtacgtca ttgctcagcc ggggatcggt cagcgcggcg cgggcctctt catggccgac
    16081 gacgagccag aacacaccgg aggtgtccgt gcgcacccgg tggaccgggc cccgttcccg
    16141 cagacgcgca tagaccggat acgggttgac gacgaaatcc gcgccgagcg cggacagatc
    16201 ctggggcatg tgatcccctc agtcggttga cggcttcccc cgaagccaga accggggatc
    16261 gttccccgct ctgtcgatga tcttaacacc taaccggaga gattcccccg gttagtgtta
    16321 gggttgcggg ccatgggcag ccgtgtggag aaagagacac cattgcgccg agacgcgcgg
    16381 cgcaatcgcg agatgctgat aaccgccgcc cgggagatct acacggatca gggggtggac
    16441 gccccgctcg acgacatcgc ccgtcgggcc ggagtcggca gcgccaccct ctaccggcgg
    16501 ttcgccggcc gggcggaact catcgaggcg gttttcggcg attcccttcg ggacattctg
    16561 cgggcagcgg aggaggcccg ctcggcggtc gacgcctggg tcggtctgac ggcctatctc
    16621 gagcgcatct tcgggctgct cgccgccgac cggggcacca acgatctgat gaccaccggt
    16681 atacagggcg tcccctcgct cgacgcgctc cgtgaggaga acgcgaagac actcgacgtc
    16741 ctcctgcgcc gcgcccagga acagggcgcg gtccggaagg acgccaccgc ggaggacctt
    16801 cagttcatgc tggccgcact cggccgcgcg gtccccggct cgacggtcgc cgcgccactg
    16861 gcctggcgcc gctatctgtt cctgctgctg gacgggttgc gccccgaggg gtcccatccg
    16921 ctcccggccc cctcgctcac cacggagcag ctcaacgccg ccatgctcca gctcggcaag
    16981 gtgcggcggc cgcgcgcggg gcgcgccgac tagccggggt ccgggagcgc ctgctctccg
    17041 ggagcgcctc ctgctccgga agcgcctcct gttccggaag cgccgactct ccgggagcgc
    17101 gggccgtagg acgtcgtccg gggcgcgccg atgtggaggc accggggcga gggttcgggc
    17161 gaggcacctc accacagtgg tcgggcgaag tatgtcgccc gcctacatat ccgagccgaa
    17221 gagcgcattt ctacggtgtg gcaacacaaa accgttcccg caccccgctc ggaagtggtg
    17281 acccatgccc accccggatt ccccggcctc cgctcccccg accccgcccg gttcgctgcg
    17341 ccgtatcgtc gccgcgagcc tcatcggcac caccatcgag tggtacgact tcttcctcta
    17401 cggctcggcc gccgcgctcg tcttcaacaa gctcttcttc ccggactccg atccgctggt
    17461 cggcacgctg ctctcgttcc tgacgtacgc ggtcggcttc gccgcccggc cggtcggcgc
    17521 cctggtcttc ggccactacg gcgaccggct cggccgtaag aagctgctga tcctgagtct
    17581 gctgatgatg ggcggcgcga cctgcgccat cgggctgctg cccacccacg ccacggtcgg
    17641 ttcggcggca cccgtactgc tcaccgcgct gcgtctgctc caggggttcg cgctgggcgg
    17701 cgaatggggc ggggcggtgc tgctggtgtc ggaacacggg gacgcgcggc ggcgcgggtt
    17761 ctgggcgtcc tggccgcaga ccggcgcccc cgcggggcag ctgctggcca ccggggtgct
    17821 ctccgcgctg accgccctgc tctccgacag cgccttcgag tcatggggat ggcgggtgcc
    17881 gttcctgctc tcgggcgtgc tggtggtggt cggcttgtgg attcgtctct ctgtcgatga
    17941 atcgccggtg ttcaaggcgg cgctggcccg ggccgaggcc cgtaaggcgg ccacggacgg
    18001 cggtgcggac gccgccgaga agatgccgct ggtggccgtc ctgcgccacc actggcggga
    18061 tgtgctgatc gccatgggcg cgcggatggc cgagaacatc agttactacg tcatcaccgc
    18121 cttcgtcctc gtctacgcga cctccgacca tgtgggcctc ggcaagcaga ccgcgctcaa
    18181 cgccgtactg atcgcctcgg ccgtgcactt cgcggtcatc ccggcctggg gcgcgctgtc
    18241 ggaccggatc gggcgccgcc cggtgtatct cctgggcgcg gcgggtgtgg gcgcatgggc
    18301 cttccccttc ttcctcctca tcgacaccaa gggcttcccg gccctgctgc tcgccgtgac
    18361 ggtcgggctg atcttccacg gggcgatgta cgcgccccag gcggcgttct tctccgagat
    18421 gttcgcgacc cggatgcggt attcgggggc gtcgatcggg gcgcagttct cgtcggtcgc
    18481 ggccggtgcg cccgccccgc tgatcgccac cgcgctcctg gccgactacg gcagcgccac
    18541 cccgatcgcc ctctatgtga tcgcggcggc cctgctcacc ctggtggccg tgggcgtcgc
    18601 caaggagacc cgggaccgcg atctggccgc cgtggaaccg acctcggccc cctccccgcg
    18661 tccggcgtcg gagggtgcgg ggcgcaaggc ccgttcggcc tcggctcagt agcccacggc
    18721 cgaggccagt cggtgcagcc gcagggcgag ctggatctcc agggagcggg cgggcgactg
    18781 ccagtcgggg ccgagcagcc gcccgatccg ctccagccgc tgcgccaccg tgttgacgtg
    18841 cacgtggagg gcgtccttcg tacgggccgg gctcatccca ccggcgaagt acgcgtcgag
    18901 cgtgcggatc agttcggtgc cgcgccgctc gtcgtagtcg atgaccgcgc ccacggtgcg
    18961 gtgcacgaag tcctggacgc cggtgccggc cggggcgccc tcgcgggtac cggccagcag
    19021 cagaccgagg aagccgaagt cctcggcggc ggcgccctgt ccggcccggt ccagcacccg
    19081 cagggcggcc agacagcgcc gcgcctcggc atagcccgcg gcgacgtccc cgggccgcgc
    19141 ggcgggcgcg gggaccggcg cggaggcgcc gacggtgacc gcggcgtgca cggcggtgcc
    19201 gagctggcgg gcggtgcggc gggcgagggc gtcggcggtg tcgccctcgg ccagcggcag
    19261 cagcagaaca gtgccgccgt cgcgggctgc ggccagaccg tgccgggtgg ccgccagatg
    19321 ggacgcggcg gaccacagcc gacggcggcc cgcggcgtcc tcggcggggg cgccgccggg
    19381 accgcctccg ggcccggctc ccggtgcgcc gccgggcctg cttccggatg ccccgccggg
    19441 accgctcgcg cgtgcgccgc cgggaccgct cgcgggcgcg gtgccgggtc cgcctccggg
    19501 tgtggtgccc ggcccgcctc cgggtgcccc gcagggaccg gcggcgggcg taccggtgtc
    19561 cggggcctcg atgcccgcgg cgagcaccac atggggcgtg tccaggtccg cccggagccg
    19621 cgcggcgcgc tcgcgcagca gccggggctc acggtcggga gcgtcgagca ggtcgtccag
    19681 gagctcaccg cgcacccgct gctcggcctc acccgccgag cggcgggcga gctgcaacag
    19741 cgaggtgacc atggcggcgc gctccagggt gcgctggtcc atggggtcga gccgggggtg
    19801 gccgcgcagt acgagcgcgc cgagcagttc gccacccgcc gagacggcgg cgacccaatc
    19861 ctcctcgccg tcgcgcaccg cgtggccatc ggcccgggac cggtcgacgg ccgccgcggg
    19921 cgcctcgtcg gtctcgagga actccacgga gccgctgagc acctcggcca gcgcgtccgc
    19981 cacgtcgtgc accccgccac cgcgcagcac cagctcggtg agccggtcat ggacgtcgga
    20041 ggcgcgctcg atgacccggc tgcggtcccg gatgatctcg ttggccgcct ccagttcggc
    20101 gagcgccgta cgggtctcgg cgagcagatg ggcggtgtcg atggccacgg ccgcgtgggc
    20161 ggcgaacgag ccgagcagcg cgatctgctc gcgttcgaac acccgggccc tgcggtcggc
    20221 cgcgaacagc acgccgatga caccgctgcc cagcagcagc ggcaccccga ggatggcgac
    20281 gagcccctcg tccctgacgc ccgcgtcgat ggcgtgcgtg tgctggaacc gcggatcgtc
    20341 gaagtagttc tcggtcacat aggggcgggc ggtctgggcc accagaccgc cgagcccctc
    20401 ccccatgccg agccgcaact gctggaagcg ggccgagacc gaaccgtcgg tgaccctcat
    20461 ataggtgtca ccggccgtcg gatcgttgag cgtcagatac gcgacctcgg tgcccagcag
    20521 ggagcgggcg cgctggacga tggcctggag caccgcgtcc agatcgcgca gccccgccag
    20581 atcgtgggcg gtctcgaaga gcgcggagag ctcggcctcg cggcgccgtc gcccctccag
    20641 ctcgccgcgc acccgcaggg cgagcagctt ggcgcgctcc agggccgcca gcagctcggc
    20701 cggggccttg tcggcgcggg cgcgcagcac cgggcgctcg tacgcctcgg cgggcgcgcc
    20761 gcgtacgagc agttccaggt agggggcctc cggccggtcg tcgggcatgg tcacaggcat
    20821 actcccgccg gacgcggcgg cgccagccgt agggcggccc ggtgtccttt cgagggggcg
    20881 gccgggcaag aggcggtccg gtggctgagc caatgagcca ccattccgcc cgtccggcag
    20941 tggctgagcc actgagccgc tctcccgccc ctccggcagt ggctgagcca atcggccacc
    21001 atccgccggt ggctcagcca atcggccttc ctggcccagt ggctcagcca atcggccttc
    21061 accggccgat gaacgatccg atgagccgct cagtgggcgg tccatccgcc gtccatgctg
    21121 agcgaggcac cggtgacgaa ggacgtatgc ggaccgcaga gatacgcgac ggcctcggcg
    21181 acctcctcgg gttcgaccag ccgcttgacc gccgaatcgg ccagcatcac atcggagacc
    21241 acccgctccg gcgagatccc gtgggcctcg gcctggtcgg cgatctgccg ctcgacgagc
    21301 ggggtgcgca catagccggg gttgacgcaa ttggaggtca ccccgtgcgc cgcgccctcc
    21361 agggcggcga ccttggacag cccctccagg ccgtgtttgg cggccacata ggccgacttg
    21421 tagggggagg cgcgcagccc gtgcaccgag gagatgttca cgatccggcc ccagccccgc
    21481 gcgtacatat gcggcagcgc gccgcgcacc agccggaacg gggcctcgag catcacggtg
    21541 agcacccggg agaacacctc gggcggaaag tcctcgatgg gccggacgag ttggagcccg
    21601 gcgttgttga ccaggatgtc gatgccggcg gcggcccgtt cggcggcgtc gaggtcggtg
    21661 aggtccaggg ggtgggcctc gacctggccg ggcaatccgg cggccgcgtc gaccaggtcg
    21721 gtgaggccct cggcgtccag gtcgacggcc cgcacccgcg ccccggcggt ggccagccgc
    21781 agtgtgcagg cccggccgat gcccccggcg gcgcccgtga cgagtgcggt acggcaggac
    21841 agatcggggc cgtcggacgg ccgggggccc gggcccggtg tggtggacgc gctcatgagt
    21901 ggcacattag gcagccatcg tgcccggacc gatgtgcggg cggcacatac ttcactccgc
    21961 gacgatgggc tcgaaccatg tcgggccgtc ctcgagcgcc
//
